APOBEC4 Gene
protein-coding GIFtS: 40
GCID: GC01M183615
|
|
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like...(Previous name: chromosome 1 open reading frame 169 )
(Previous symbol: C1orf169)
| |
Aliases
for APOBEC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 4(Putative)1 2 | | RP1-127C7.41 | | C1orf1691 2 3 | | Chromosome 1 Open Reading Frame 1691 | | Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 42 3 | | Putative C->U-Editing Enzyme APOBEC-42 | | FLJ256911 | | EC 3.5.4.-3 | | MGC265941 | | |
Export aliases for APOBEC4 gene to outside databasesPrevious GC identifers: GC01M180349 GC01M181882 GC01M154851 |
Summaries
for APOBEC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for APOBEC4:
This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convertcytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation andrecombination of immunoglobulin genes, and innate immunity to retroviral infection. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ABEC4_HUMAN, Q8WW27Function: Putative C to U editing enzyme whose physiological substrate is not yet known (By similarity)
Gene Wiki entry for APOBEC4
|
Genomic Views
for APOBEC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the APOBEC4 gene promoter:
USF1 Sox5 MEF-2A FAC1 SREBP-1a USF-1 FOXJ2 (long isoform) ZID aMEF-2 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for APOBEC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25.3 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25.3APOBEC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M183615: view genomic region
(about GC identifiers)
Start:
|
183,615,410 bp from pter |
End:
|
183,622,451 bp from pter |
Size:
|
7,042 bases |
Orientation:
|
minus strand |
|
Proteins
for APOBEC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ABEC4_HUMAN, Q8WW27 (See
protein sequence)Recommended Name: Putative C->U-editing enzyme APOBEC-4 Size: 367 amino acids; 41581 Da
Cofactor: Zinc (By similarity)
Secondary accessions: Q8N7F6Explore the universe of human proteins at neXtProt for APOBEC4: NX_Q8WW27
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WW27
APOBEC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_982279.1
ENSEMBL proteins: ENSP00000310622
Human Recombinant Protein Products:
APOBEC4 Antibody Products:
Assay Products for APOBEC4: |
Protein
Domains /
Families
for APOBEC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
APOBEC4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WW27ProtoNet protein and cluster: Q8WW27 1 Blocks protein family: IPB002125 Cytidine/deoxycytidylate deaminase
UniProtKB/Swiss-Prot: ABEC4_HUMAN, Q8WW27Similarity: Belongs to the cytidine and deoxycytidylate deaminase family |
Function
for APOBEC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ABEC4_HUMAN, Q8WW27Function: Putative C to U editing enzyme whose physiological substrate is not yet known (By similarity)Enzyme Number (IUBMB): EC 3.5.4.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOBEC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOBEC4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: APOBEC4 (NM_203454) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APOBEC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
IEA | -- |
APOBEC4 for ontologies About GeneDecksing
|
Pathways & Interactions
for APOBEC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOBEC4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/14 Interacting proteins for APOBEC4 (ENSP000003106224) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006397 | mRNA processing |
IEA | -- |
APOBEC4 for ontologies About GeneDecksing
|
Drugs & Compounds
for APOBEC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for APOBEC4
Search CenterWatch for drugs/clinical trials and news about APOBEC4 / ABEC4
|
Transcripts
for APOBEC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for APOBEC4 gene: NM_203454.2 Unigene Cluster for APOBEC4: Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) Hs.97335 [show with all ESTs]Unigene Representative Sequence: NM_2034542 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000308641(uc001gqn.3) ENST00000481562
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOBEC4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOBEC4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: APOBEC4 (NM_203454) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APOBEC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC4 |
Additional cDNA sequence: AK098557.1 BC021711.2 1 DOTS entry: DT.40224150 17 AceView cDNA sequences: BC021711 BU676426 BX094690 NM_203454 AA292880 AI961390 AA382354 BI770442 AK098557 AA406043 AA496090 BI828948 BG722665 AA401696 CD684537 CD710557 BI770969
GeneLoc Exon Structure
|
Expression
for APOBEC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| APOBEC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAAATT
About this image
See APOBEC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APOBEC4
SOURCE GeneReport for Unigene cluster: Hs.97335
UniProtKB/Swiss-Prot: ABEC4_HUMAN, Q8WW27Tissue specificity: Predominantly expressed in testis
SABiosciences Custom PCR Arrays for APOBEC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOBEC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APOBEC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOBEC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOBEC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC4 |
Orthologs
for APOBEC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for APOBEC4 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for APOBEC4 (if available)
TreeFam Gene Tree for APOBEC4 (if available) |
Paralogs
for APOBEC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for APOBEC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for APOBEC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 APOBEC4 for disorders About MalaCards
APOBEC4 for disorders About GeneDecksing
OMIM gene information: 609908
OMIM disorders: --
Export disorders for APOBEC4 gene to outside databases
|
Publications
for APOBEC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for APOBEC4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with APOBEC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis. (PubMed id 16082223)1, 2, 3 Rogozin I.B.... Koonin E.V. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- APOBEC deaminases-mutases with defensive roles for im munity. (PubMed id 19911124)1 Prochnow C....Chen X.S. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for APOBEC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing APOBEC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing APOBEC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing APOBEC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for APOBEC4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for APOBEC4 gene:
Search GeneIP for patents involving APOBEC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for APOBEC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for APOBEC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOBEC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOBEC4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for APOBEC4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOBEC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOBEC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for APOBEC4 | | OriGene Custom Protein Services for APOBEC4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APOBEC4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOBEC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOBEC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOBEC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOBEC4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for APOBEC4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | APOBEC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC4 |
|  |  |  | | | | Search ThermoFisher Antibodies for APOBEC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC4 |
|
|
|
|
