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Aliases for APOBEC3H Gene

Aliases for APOBEC3H Gene

  • Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3H 2 3
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3H 2 3 5
  • APOBEC-Related Protein 10 3 4
  • ARP-10 3 4
  • A3H 3 4
  • Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide Like 3H 3
  • Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 3H 4
  • EC 3.5.4.- 4
  • Arp10 3

External Ids for APOBEC3H Gene

Previous GeneCards Identifiers for APOBEC3H Gene

  • GC22P037823
  • GC22P039493
  • GC22P022460

Summaries for APOBEC3H Gene

Entrez Gene Summary for APOBEC3H Gene

  • This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for APOBEC3H Gene

APOBEC3H (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3H) is a Protein Coding gene. Diseases associated with APOBEC3H include Hiv-1. GO annotations related to this gene include hydrolase activity and cytidine deaminase activity. An important paralog of this gene is AICDA.

UniProtKB/Swiss-Prot for APOBEC3H Gene

  • DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

Gene Wiki entry for APOBEC3H Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3H Gene

Genomics for APOBEC3H Gene

Regulatory Elements for APOBEC3H Gene

Enhancers for APOBEC3H Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APOBEC3H on UCSC Golden Path with GeneCards custom track

Genomic Location for APOBEC3H Gene

Chromosome:
22
Start:
39,097,223 bp from pter
End:
39,104,067 bp from pter
Size:
6,845 bases
Orientation:
Plus strand

Genomic View for APOBEC3H Gene

Genes around APOBEC3H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOBEC3H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOBEC3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBEC3H Gene

Proteins for APOBEC3H Gene

  • Protein details for APOBEC3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NTF7-ABC3H_HUMAN
    Recommended name:
    DNA dC->dU-editing enzyme APOBEC-3H
    Protein Accession:
    Q6NTF7
    Secondary Accessions:
    • B0QYP0
    • B0QYP1
    • B7TQM5
    • E9PF38
    • Q5JYL9
    • Q6IC87

    Protein attributes for APOBEC3H Gene

    Size:
    200 amino acids
    Molecular mass:
    23531 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with AGO1, AGO2 and AGO3.
    Miscellaneous:
    • APOBEC3H from old world monkeys has retained its antiviral activity, while it is lost in other primates.
    • It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.

    Alternative splice isoforms for APOBEC3H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOBEC3H Gene

Proteomics data for APOBEC3H Gene at MOPED

Post-translational modifications for APOBEC3H Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for APOBEC3H Gene

Domains & Families for APOBEC3H Gene

Graphical View of Domain Structure for InterPro Entry

Q6NTF7

UniProtKB/Swiss-Prot:

ABC3H_HUMAN :
  • Contains 1 CMP/dCMP-type deaminase domain.
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with APOBEC3H: view

Function for APOBEC3H Gene

Molecular function for APOBEC3H Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cytidine + H(2)O = uridine + NH(3).
UniProtKB/Swiss-Prot EnzymeRegulation:
Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents its incorporation into progeny virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome.
UniProtKB/Swiss-Prot Function:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

Enzyme Numbers (IUBMB) for APOBEC3H Gene

Gene Ontology (GO) - Molecular Function for APOBEC3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004126 cytidine deaminase activity IDA 16571802
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with APOBEC3H: view
genes like me logo Genes that share phenotypes with APOBEC3H: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOBEC3H Gene

Localization for APOBEC3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3H Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOBEC3H Gene COMPARTMENTS Subcellular localization image for APOBEC3H gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for APOBEC3H Gene

Pathways & Interactions for APOBEC3H Gene

SuperPathways for APOBEC3H Gene

No Data Available

Interacting Proteins for APOBEC3H Gene

Gene Ontology (GO) - Biological Process for APOBEC3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010529 negative regulation of transposition IMP,IDA 18827027
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA 18779051
GO:0048525 negative regulation of viral process IMP 18827027
GO:0070383 DNA cytosine deamination IDA 16571802
genes like me logo Genes that share ontologies with APOBEC3H: view

No data available for Pathways by source and SIGNOR curated interactions for APOBEC3H Gene

Drugs & Compounds for APOBEC3H Gene

(2) Drugs for APOBEC3H Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytidine Experimental Pharma 0
Uridine Experimental Pharma 0

(2) Additional Compounds for APOBEC3H Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with APOBEC3H: view

Transcripts for APOBEC3H Gene

Unigene Clusters for APOBEC3H Gene

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC3H Gene

No ASD Table

Relevant External Links for APOBEC3H Gene

GeneLoc Exon Structure for
APOBEC3H
ECgene alternative splicing isoforms for
APOBEC3H

Expression for APOBEC3H Gene

mRNA expression in normal human tissues for APOBEC3H Gene

mRNA differential expression in normal tissues according to GTEx for APOBEC3H Gene

This gene is overexpressed in Whole Blood (x6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOBEC3H Gene



SOURCE GeneReport for Unigene cluster for APOBEC3H Gene Hs.440515

mRNA Expression by UniProt/SwissProt for APOBEC3H Gene

Q6NTF7-ABC3H_HUMAN
Tissue specificity: Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin.
genes like me logo Genes that share expression patterns with APOBEC3H: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for APOBEC3H Gene

Orthologs for APOBEC3H Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOBEC3H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOBEC3H 35
  • 97.61 (n)
  • 94.48 (a)
APOBEC3H 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOBEC3Z3 36
  • 23 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOBEC3H 36
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apobec3 36
  • 19 (a)
OneToOne
Species with no ortholog for APOBEC3H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOBEC3H Gene

ENSEMBL:
Gene Tree for APOBEC3H (if available)
TreeFam:
Gene Tree for APOBEC3H (if available)

Paralogs for APOBEC3H Gene

genes like me logo Genes that share paralogs with APOBEC3H: view

Variants for APOBEC3H Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3H Gene

ABC3H_HUMAN-Q6NTF7
There are at least 4 different haplotypes in the human population. The allele A3H-var/haplotype 2 encodes a more stable protein which is able to block HIV-1 replication. The displayed allele (haplotype 1) is unstable and inefficient to block HIV-1 replication.

Sequence variations from dbSNP and Humsavar for APOBEC3H Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs139293 - 39,100,331(+) GCGCC(A/G/T)CCTCA reference, missense
rs139297 - 39,101,399(+) ACCTG(A/C/G)GCATC reference, missense
rs139298 - 39,101,447(+) AGCAG(A/G)AGGGG reference, missense
rs139299 - 39,101,449(+) CAGAA(C/G/T)GGGCT reference, missense
rs139302 - 39,102,033(+) CTTGA(C/G)AGGAT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for APOBEC3H Gene

Variant ID Type Subtype PubMed ID
nsv834196 CNV Loss 17160897
nsv510807 CNV Loss 20534489
nsv834197 CNV Gain 17160897
nsv915090 CNV Loss 21882294
dgv4973n71 CNV Loss 21882294

Variation tolerance for APOBEC3H Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.52; 92.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOBEC3H Gene

Human Gene Mutation Database (HGMD)
APOBEC3H

Disorders for APOBEC3H Gene

MalaCards: The human disease database

(1) MalaCards diseases for APOBEC3H Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for APOBEC3H

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOBEC3H
genes like me logo Genes that share disorders with APOBEC3H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APOBEC3H Gene

Publications for APOBEC3H Gene

  1. Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H. (PMID: 16571802) OhAinle M. … Emerman M. (J. Virol. 2006) 2 3 4 67
  2. The assembly of Vif ubiquitin E3 ligase for APOBEC3 degradation. (PMID: 25408426) Kim D.Y. (Arch. Pharm. Res. 2015) 3
  3. Evolutionarily conserved pressure for the existence of distinct G2/M cell cycle arrest and A3H inactivation functions in HIV-1 Vif. (PMID: 25590520) Zhao K. … Yu X.F. (Cell Cycle 2015) 3
  4. Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities. (PMID: 25614027) Mitra M. … Levin J.G. (Retrovirology 2015) 3
  5. APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese. (PMID: 25721876) Sakurai D. … Kimura A. (Immunogenetics 2015) 3

Products for APOBEC3H Gene

Sources for APOBEC3H Gene

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