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Aliases for APOBEC3H Gene

Aliases for APOBEC3H Gene

  • Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3H 2 3 5
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3H 2 3
  • APOBEC-Related Protein 10 3 4
  • ARP-10 3 4
  • A3H 3 4
  • Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 3H 4
  • DNA DC->DU-Editing Enzyme APOBEC-3H 3
  • EC 3.5.4.- 4
  • Arp10 3

External Ids for APOBEC3H Gene

Previous GeneCards Identifiers for APOBEC3H Gene

  • GC22P037823
  • GC22P039493
  • GC22P022460

Summaries for APOBEC3H Gene

Entrez Gene Summary for APOBEC3H Gene

  • This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for APOBEC3H Gene

APOBEC3H (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3H) is a Protein Coding gene. Diseases associated with APOBEC3H include Hiv-1. Among its related pathways are mRNA Editing- C to U Conversion and Gene Expression. GO annotations related to this gene include hydrolase activity and cytidine deaminase activity. An important paralog of this gene is APOBEC3C.

UniProtKB/Swiss-Prot for APOBEC3H Gene

  • DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

Gene Wiki entry for APOBEC3H Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3H Gene

Genomics for APOBEC3H Gene

Regulatory Elements for APOBEC3H Gene

Enhancers for APOBEC3H Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F039087 1.4 FANTOM5 Ensembl ENCODE 18 -6.7 -6690 5.7 HDGF RAD21 ZNF121 GLIS2 CREM EGR2 CEBPB NCOA1 ELF1 REST APOBEC3G APOBEC3H SUN2 APOBEC3C ENSG00000273076 JOSD1 GTPBP1 APOBEC3D LOC101927202 PIR39490
GH22F039094 1 Ensembl ENCODE 16.4 +0.2 244 6.7 HDGF ATF1 PKNOX1 CREB3L1 WRNIP1 SIN3A FEZF1 ZNF2 ZNF48 YY1 APOBEC3G APOBEC3H ENSG00000230149 ENSG00000273076 SNORD83B ENSG00000272669 KDELR3 ENSG00000225450 APOBEC3D PRDX3P1
GH22F039128 0.4 ENCODE 12.3 +32.1 32122 1.2 ELF3 HIC1 ZNF316 ZNF366 POLR2A NR2F6 PRDM10 ZNF263 GATAD2A MAZ APOBEC3H APOBEC3B-AS1 SYNGR1 APOBEC3G APOBEC3C PIR42151 COX5BP7
GH22F039130 1 Ensembl ENCODE 12.2 +34.1 34078 1.8 ELF3 PKNOX1 ARID4B THRB RARA SCRT2 EGR2 SP5 CEBPB TGIF2 APOBEC3H FUNDC2P4 CBX7 APOBEC3B-AS1 RPL3 NPTXR SYNGR1 APOBEC3G PIR42151 COX5BP7
GH22F039135 0.6 ENCODE 12.1 +38.1 38058 0.2 CTCF REST RAD21 ZNF143 SMC3 NR2F6 KDM6A ZBTB17 TRIM28 APOBEC3H FUNDC2P4 APOBEC3B-AS1 NPTXR SYNGR1 ENSG00000279833 CBX7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around APOBEC3H on UCSC Golden Path with GeneCards custom track

Genomic Location for APOBEC3H Gene

Chromosome:
22
Start:
39,097,223 bp from pter
End:
39,104,067 bp from pter
Size:
6,845 bases
Orientation:
Plus strand

Genomic View for APOBEC3H Gene

Genes around APOBEC3H on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOBEC3H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOBEC3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBEC3H Gene

Proteins for APOBEC3H Gene

  • Protein details for APOBEC3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NTF7-ABC3H_HUMAN
    Recommended name:
    DNA dC->dU-editing enzyme APOBEC-3H
    Protein Accession:
    Q6NTF7
    Secondary Accessions:
    • B0QYP0
    • B0QYP1
    • B7TQM5
    • E9PF38
    • Q5JYL9
    • Q6IC87

    Protein attributes for APOBEC3H Gene

    Size:
    200 amino acids
    Molecular mass:
    23531 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with AGO1, AGO2 and AGO3.
    Miscellaneous:
    • APOBEC3H from old world monkeys has retained its antiviral activity, while it is lost in other primates.
    • It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.

    Alternative splice isoforms for APOBEC3H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOBEC3H Gene

Post-translational modifications for APOBEC3H Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for APOBEC3H Gene

Domains & Families for APOBEC3H Gene

Graphical View of Domain Structure for InterPro Entry

Q6NTF7

UniProtKB/Swiss-Prot:

ABC3H_HUMAN :
  • Contains 1 CMP/dCMP-type deaminase domain.
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with APOBEC3H: view

Function for APOBEC3H Gene

Molecular function for APOBEC3H Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cytidine + H(2)O = uridine + NH(3).
UniProtKB/Swiss-Prot EnzymeRegulation:
Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents its incorporation into progeny virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome.
UniProtKB/Swiss-Prot Function:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

Enzyme Numbers (IUBMB) for APOBEC3H Gene

Gene Ontology (GO) - Molecular Function for APOBEC3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004126 cytidine deaminase activity IDA 16571802
GO:0005515 protein binding IPI 22915799
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with APOBEC3H: view
genes like me logo Genes that share phenotypes with APOBEC3H: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOBEC3H Gene

Localization for APOBEC3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3H Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOBEC3H Gene COMPARTMENTS Subcellular localization image for APOBEC3H gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for APOBEC3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 22915799
GO:0005634 nucleus IEA,IDA 18779051
GO:0005737 cytoplasm IEA,IDA 18779051
genes like me logo Genes that share ontologies with APOBEC3H: view

Pathways & Interactions for APOBEC3H Gene

genes like me logo Genes that share pathways with APOBEC3H: view

Pathways by source for APOBEC3H Gene

Interacting Proteins for APOBEC3H Gene

Gene Ontology (GO) - Biological Process for APOBEC3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0009972 cytidine deamination IEA --
GO:0010529 negative regulation of transposition IMP 18827027
GO:0045087 innate immune response IEA --
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA 18779051
genes like me logo Genes that share ontologies with APOBEC3H: view

No data available for SIGNOR curated interactions for APOBEC3H Gene

Drugs & Compounds for APOBEC3H Gene

(3) Drugs for APOBEC3H Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Cytidine Experimental Pharma 0
Uridine Experimental Pharma 0

(1) Additional Compounds for APOBEC3H Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
genes like me logo Genes that share compounds with APOBEC3H: view

Transcripts for APOBEC3H Gene

Unigene Clusters for APOBEC3H Gene

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC3H Gene

No ASD Table

Relevant External Links for APOBEC3H Gene

GeneLoc Exon Structure for
APOBEC3H
ECgene alternative splicing isoforms for
APOBEC3H

Expression for APOBEC3H Gene

mRNA expression in normal human tissues for APOBEC3H Gene

mRNA differential expression in normal tissues according to GTEx for APOBEC3H Gene

This gene is overexpressed in Whole Blood (x6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOBEC3H Gene



NURSA nuclear receptor signaling pathways regulating expression of APOBEC3H Gene:

APOBEC3H

SOURCE GeneReport for Unigene cluster for APOBEC3H Gene:

Hs.440515

mRNA Expression by UniProt/SwissProt for APOBEC3H Gene:

Q6NTF7-ABC3H_HUMAN
Tissue specificity: Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin.
genes like me logo Genes that share expression patterns with APOBEC3H: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for APOBEC3H Gene

Orthologs for APOBEC3H Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOBEC3H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOBEC3H 34 35
  • 97.61 (n)
dog
(Canis familiaris)
Mammalia APOBEC3H 35
  • 45 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOBEC3Z3 35
  • 23 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apobec3 35
  • 19 (a)
OneToOne
Species where no ortholog for APOBEC3H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOBEC3H Gene

ENSEMBL:
Gene Tree for APOBEC3H (if available)
TreeFam:
Gene Tree for APOBEC3H (if available)

Paralogs for APOBEC3H Gene

genes like me logo Genes that share paralogs with APOBEC3H: view

Variants for APOBEC3H Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3H Gene

ABC3H_HUMAN-Q6NTF7
There are at least 4 different haplotypes in the human population. The allele A3H-var/haplotype 2 encodes a more stable protein which is able to block HIV-1 replication. The displayed allele (haplotype 1) is unstable and inefficient to block HIV-1 replication.

Sequence variations from dbSNP and Humsavar for APOBEC3H Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111264862 -- 39,102,694(+) TGTAC(C/T)TCTCA intron-variant, downstream-variant-500B
rs111799469 -- 39,103,176(+) CCAGC(C/G)ATTCG intron-variant
rs112015703 -- 39,095,899(+) CAGGC(A/G)TGAGC upstream-variant-2KB
rs112070489 -- 39,102,369(+) GTCTT(A/G/T)GAACT intron-variant
rs112153951 -- 39,096,882(+) GAGAC(C/G)GGGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for APOBEC3H Gene

Variant ID Type Subtype PubMed ID
nsv1066354 CNV gain 25217958
nsv510807 CNV deletion 20534489
nsv834196 CNV loss 17160897
nsv834197 CNV gain 17160897

Variation tolerance for APOBEC3H Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.52; 92.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOBEC3H Gene

Human Gene Mutation Database (HGMD)
APOBEC3H
SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOBEC3H

Disorders for APOBEC3H Gene

MalaCards: The human disease database

(1) MalaCards diseases for APOBEC3H Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for APOBEC3H

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOBEC3H
genes like me logo Genes that share disorders with APOBEC3H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APOBEC3H Gene

Publications for APOBEC3H Gene

  1. Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H. (PMID: 16571802) OhAinle M. … Emerman M. (J. Virol. 2006) 2 3 4 64
  2. APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ t cells and macrophages. (PMID: 23097438) Chaipan C. … Pathak V.K. (J. Virol. 2013) 3 4 64
  3. APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T- lymphotropic virus type 1. (PMID: 22457529) Ooms M. … Muenk C. (J. Virol. 2012) 3 4 64
  4. Retroelements versus APOBEC3 family members: No great escape from the magnificent seven. (PMID: 22912627) Arias J.F. … Tokunaga K. (Front. Microbiol. 2012) 3 4 64
  5. HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. (PMID: 22915799) Phalora P.K. … Malim M.H. (J. Virol. 2012) 3 4 64

Products for APOBEC3H Gene

Sources for APOBEC3H Gene

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