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Aliases for APOBEC3H Gene

Aliases for APOBEC3H Gene

  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3H 2 3
  • APOBEC-Related Protein 10 3 4
  • ARP-10 3 4
  • ARP10 3 6
  • A3H 3 4
  • Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 3H 4
  • DNA DC->DU-Editing Enzyme APOBEC-3H 3
  • EC 3.5.4.- 4

External Ids for APOBEC3H Gene

Summaries for APOBEC3H Gene

Entrez Gene Summary for APOBEC3H Gene

  • This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for APOBEC3H Gene

APOBEC3H (Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3H) is a Protein Coding gene. Diseases associated with APOBEC3H include hiv-1. GO annotations related to this gene include cytidine deaminase activity. An important paralog of this gene is AICDA.

UniProtKB/Swiss-Prot for APOBEC3H Gene

  • DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

Gene Wiki entry for APOBEC3H Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3H Gene

Genomics for APOBEC3H Gene

Genomic Location for APOBEC3H Gene

Start:
39,097,224 bp from pter
End:
39,104,067 bp from pter
Size:
6,844 bases
Orientation:
Plus strand

Genomic View for APOBEC3H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOBEC3H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBEC3H Gene

Regulatory Elements for APOBEC3H Gene

Proteins for APOBEC3H Gene

  • Protein details for APOBEC3H Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NTF7-ABC3H_HUMAN
    Recommended name:
    DNA dC->dU-editing enzyme APOBEC-3H
    Protein Accession:
    Q6NTF7
    Secondary Accessions:
    • B0QYP0
    • B0QYP1
    • B7TQM5
    • E9PF38
    • Q5JYL9
    • Q6IC87

    Protein attributes for APOBEC3H Gene

    Size:
    200 amino acids
    Molecular mass:
    23531 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with AGO1, AGO2 and AGO3.
    Miscellaneous:
    • APOBEC3H from old world monkeys has retained its antiviral activity, while it is lost in other primates
    • It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22

    Alternative splice isoforms for APOBEC3H Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOBEC3H Gene

Proteomics data for APOBEC3H Gene at MOPED

Post-translational modifications for APOBEC3H Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for APOBEC3H Gene

Domains for APOBEC3H Gene

Gene Families for APOBEC3H Gene

HGNC:
  • APOBEC :Apolipoprotein B mRNA editing enzymes

UniProtKB/Swiss-Prot:

ABC3H_HUMAN
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.:
    • Q6NTF7
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.:
    • Q6NTF7
genes like me logo Genes that share domains with APOBEC3H: view

Function for APOBEC3H Gene

Molecular function for APOBEC3H Gene

UniProtKB/Swiss-Prot CatalyticActivity: Cytidine + H(2)O = uridine + NH(3)
UniProtKB/Swiss-Prot EnzymeRegulation: Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents its incorporation into progeny virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome.
UniProtKB/Swiss-Prot Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

Enzyme Numbers (IUBMB) for APOBEC3H Gene

Gene Ontology (GO) - Molecular Function for APOBEC3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004126 cytidine deaminase activity IDA 16571802
GO:0005515 protein binding IPI 22915799
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with APOBEC3H: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APOBEC3H Gene

Localization for APOBEC3H Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3H Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOBEC3H Gene COMPARTMENTS Subcellular localization image for APOBEC3H gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for APOBEC3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 22915799
GO:0005634 nucleus IDA 18779051
GO:0005737 cytoplasm IDA 18779051
genes like me logo Genes that share ontologies with APOBEC3H: view

Pathways for APOBEC3H Gene

SuperPathways for APOBEC3H Gene

No Data Available

Interacting Proteins for APOBEC3H Gene

Gene Ontology (GO) - Biological Process for APOBEC3H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0009972 cytidine deamination IDA 16571802
GO:0010529 negative regulation of transposition IMP 18827027
GO:0045087 innate immune response IEA --
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA 18779051
genes like me logo Genes that share ontologies with APOBEC3H: view

No data available for Pathways by source for APOBEC3H Gene

Compounds for APOBEC3H Gene

(1) HMDB Compounds for APOBEC3H Gene

Compound Synonyms Cas Number PubMed IDs
Cytidine
  • 1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
65-46-3
genes like me logo Genes that share compounds with APOBEC3H: view

Transcripts for APOBEC3H Gene

Unigene Clusters for APOBEC3H Gene

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC3H Gene

No ASD Table

Relevant External Links for APOBEC3H Gene

GeneLoc Exon Structure for
APOBEC3H
ECgene alternative splicing isoforms for
APOBEC3H

Expression for APOBEC3H Gene

mRNA expression in normal human tissues for APOBEC3H Gene

mRNA differential expression in normal tissues according to GTEx for APOBEC3H Gene

This gene is overexpressed in Whole Blood (6.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for APOBEC3H Gene

SOURCE GeneReport for Unigene cluster for APOBEC3H Gene Hs.440515

mRNA Expression by UniProt/SwissProt for APOBEC3H Gene

Q6NTF7-ABC3H_HUMAN
Tissue specificity: Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin.
genes like me logo Genes that share expressions with APOBEC3H: view

Orthologs for APOBEC3H Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOBEC3H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOBEC3H 36
  • 97.61 (n)
  • 94.48 (a)
APOBEC3H 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOBEC3Z3 37
  • 23 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOBEC3H 37
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apobec3 37
  • 19 (a)
OneToOne
Species with no ortholog for APOBEC3H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOBEC3H Gene

ENSEMBL:
Gene Tree for APOBEC3H (if available)
TreeFam:
Gene Tree for APOBEC3H (if available)

Paralogs for APOBEC3H Gene

genes like me logo Genes that share paralogs with APOBEC3H: view

Variants for APOBEC3H Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3H Gene

Q6NTF7-ABC3H_HUMAN
There are at least 4 different haplotypes in the human population. The allele A3H-var/haplotype 2 encodes a more stable protein which is able to block HIV-1 replication. The displayed allele (haplotype 1) is unstable and inefficient to block HIV-1 replication

Sequence variations from dbSNP and Humsavar for APOBEC3H Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs113023 -- 39,096,758(+) tgcga(C/T)gtcgg upstream-variant-2KB
rs139278 -- 39,097,929(+) ACCAG(-/T)TAACA intron-variant
rs139279 -- 39,098,079(+) CAGCT(C/G)CATGG intron-variant
rs139280 -- 39,098,082(+) CTCCA(C/T)GGCCT intron-variant
rs139281 -- 39,098,306(+) ATCTC(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOBEC3H Gene

Variant ID Type Subtype PubMed ID
nsv834196 CNV Loss 17160897
nsv510807 CNV Loss 20534489
nsv834197 CNV Gain 17160897
nsv915090 CNV Loss 21882294
dgv4973n71 CNV Loss 21882294

Relevant External Links for APOBEC3H Gene

HapMap Linkage Disequilibrium report
APOBEC3H
Human Gene Mutation Database (HGMD)
APOBEC3H

Disorders for APOBEC3H Gene

(1) MalaCards Diseases for APOBEC3H Gene

Search for APOBEC3H Gene in MalaCards »
genes like me logo Genes that share disorders with APOBEC3H: view

No data available for UniProtKB/Swiss-Prot for APOBEC3H Gene

Publications for APOBEC3H Gene

  1. Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H. (PMID: 16571802) OhAinle M. … Emerman M. (J. Virol. 2006) 2 3 4
  2. Human cytidine deaminase APOBEC3H restricts HIV-1 replication. (PMID: 18299330) Dang Y. … Zheng Y.H. (J. Biol. Chem. 2008) 3 4
  3. Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction. (PMID: 20308164) Refsland E.W. … Harris R.S. (Nucleic Acids Res. 2010) 3 4
  4. Antiretroelement activity of APOBEC3H was lost twice in recent human evolution. (PMID: 18779051) OhAinle M. … Emerman M. (Cell Host Microbe 2008) 3 4
  5. Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1. (PMID: 18827027) Tan L. … Yu X.F. (FASEB J. 2009) 3 4

Products for APOBEC3H Gene

Sources for APOBEC3H Gene

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