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Aliases for APOBEC3G Gene

Aliases for APOBEC3G Gene

  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G 2 3
  • CEM15 3 4 6
  • APOBEC-Related Cytidine Deaminase 3 4
  • APOBEC-Related Protein 9 3 4
  • Deoxycytidine Deaminase 3 4
  • MDS019 3 6
  • CEM-15 3 4
  • ARP-9 3 4
  • ARCD 3 4
  • A3G 3 4
  • Apolipoprotein B Editing Enzyme Catalytic Polypeptide-Like 3G 3
  • Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide 3G 3
  • Apolipoprotein B MRNA Editing Enzyme Cytidine Deaminase 3
  • DNA DC->DU-Editing Enzyme APOBEC-3G 3
  • Phorbolin-Like Protein MDS019 3
  • DNA DC->DU Editing Enzyme 3
  • APOBEC-Related Protein 4
  • DJ494G10.1 3
  • EC 3.5.4.5 63
  • EC 3.5.4.- 4
  • BK150C2.7 3
  • FLJ12740 6
  • EC 3.5.4 63
  • ARP9 3

External Ids for APOBEC3G Gene

Summaries for APOBEC3G Gene

Entrez Gene Summary for APOBEC3G Gene

  • This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOBEC3G Gene

APOBEC3G (Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G) is a Protein Coding gene. Diseases associated with APOBEC3G include human immunodeficiency virus infectious disease and hiv-1. Among its related pathways are Disease and Integrated Breast Cancer Pathway. GO annotations related to this gene include RNA binding and cytidine deaminase activity. An important paralog of this gene is AICDA.

UniProtKB/Swiss-Prot for APOBEC3G Gene

  • DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.

Gene Wiki entry for APOBEC3G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3G Gene

Genomics for APOBEC3G Gene

Genomic Location for APOBEC3G Gene

Start:
39,040,961 bp from pter
End:
39,087,743 bp from pter
Size:
46,783 bases
Orientation:
Plus strand

Genomic View for APOBEC3G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOBEC3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBEC3G Gene

Regulatory Elements for APOBEC3G Gene

Proteins for APOBEC3G Gene

  • Protein details for APOBEC3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC16-ABC3G_HUMAN
    Recommended name:
    DNA dC->dU-editing enzyme APOBEC-3G
    Protein Accession:
    Q9HC16
    Secondary Accessions:
    • B2RDR9
    • Q45F02
    • Q5TF77
    • Q7Z2N1
    • Q7Z2N4
    • Q9H9H8

    Protein attributes for APOBEC3G Gene

    Size:
    384 amino acids
    Molecular mass:
    46408 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer. Homooligomer. Can bind RNA to form ribonucleoprotein complexes of high-molecular-mass (HMM) or low-molecular-mass (LMM). HMM is inactive and heterogeneous in protein composition because of binding nonselectively to cellular RNAs, which in turn are associated with variety of cellular proteins. The LMM form which is enzymatically active has few or no RNAs associated. Its ability to form homooligomer is distinct from its ability to assemble into HMM. Interacts with APOBEC3B, APOBEC3F, MOV10, AGO2, EIF4E, EIF4ENIF1, DCP2 and DDX6 in an RNA-dependent manner. Interacts with AGO1, AGO3 and PKA/PRKACA. Interacts with HIV-1 VIF and reverse transcriptase/ribonuclease H. Interacts with hepatitis B virus capsid protein.
    Miscellaneous:
    • Accumulation of APOBEC3G induced non-lethal hypermutation could contribute to the genetic variation of primate lentiviral populations
    • It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22
    SequenceCaution:
    • Sequence=CAB45274.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for APOBEC3G Gene

    Alternative splice isoforms for APOBEC3G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOBEC3G Gene

Proteomics data for APOBEC3G Gene at MOPED

Post-translational modifications for APOBEC3G Gene

  • Phosphorylation at Thr-32 reduces its binding to HIV-1 VIF and subsequent ubiquitination and degradation thus promoting its antiviral activity.
  • Ubiquitinated in the presence of HIV-1 VIF. Association with VIF targets the protein for proteolysis by the ubiquitin-dependent proteasome pathway
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys63

Other Protein References for APOBEC3G Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for APOBEC3G Gene

Gene Families for APOBEC3G Gene

HGNC:
  • APOBEC :Apolipoprotein B mRNA editing enzymes

Protein Domains for APOBEC3G Gene

Suggested Antigen Peptide Sequences for APOBEC3G Gene

Graphical View of Domain Structure for InterPro Entry

Q9HC16

UniProtKB/Swiss-Prot:

ABC3G_HUMAN
Domain:
  • The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.:
    • Q9HC16
  • Contains 2 CMP/dCMP-type deaminase domains.:
    • Q9HC16
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.:
    • Q9HC16
genes like me logo Genes that share domains with APOBEC3G: view

Function for APOBEC3G Gene

Molecular function for APOBEC3G Gene

UniProtKB/Swiss-Prot CatalyticActivity: Deoxycytidine + H(2)O = deoxyuridine + NH(3).
UniProtKB/Swiss-Prot EnzymeRegulation: Assembly into ribonucleoprotein complexes of high-molecular-mass (HMM) inhibits its enzymatic activity. Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents its incorporation into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. Can also be neutralized by simian immunodeficiency virus sooty mangabey monkey virus (SIV-sm) and chimpanzee immunodeficiency virus (SIV-cpz) VIF.
UniProtKB/Swiss-Prot Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
UniProtKB/Swiss-Prot Induction: Up-regulated by IFN-alpha

Enzyme Numbers (IUBMB) for APOBEC3G Gene

Gene Ontology (GO) - Molecular Function for APOBEC3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 11863358
GO:0003824 catalytic activity --
GO:0004126 cytidine deaminase activity TAS 17121840
GO:0005515 protein binding IPI 16699599
GO:0008270 zinc ion binding IDA 11863358
genes like me logo Genes that share ontologies with APOBEC3G: view

Phenotypes for APOBEC3G Gene

genes like me logo Genes that share phenotypes with APOBEC3G: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APOBEC3G Gene

Localization for APOBEC3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3G Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic. Small amount are found in the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 VIF.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOBEC3G Gene COMPARTMENTS Subcellular localization image for APOBEC3G gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 4
extracellular 1

Gene Ontology (GO) - Cellular Components for APOBEC3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 16699599
GO:0005737 cytoplasm IDA 16527742
GO:0005829 cytosol TAS --
GO:0030529 ribonucleoprotein complex IDA 16699599
GO:0030895 apolipoprotein B mRNA editing enzyme complex TAS 17121840
genes like me logo Genes that share ontologies with APOBEC3G: view

Pathways for APOBEC3G Gene

genes like me logo Genes that share pathways with APOBEC3G: view

Pathways by source for APOBEC3G Gene

Gene Ontology (GO) - Biological Process for APOBEC3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IDA 17121840
GO:0009972 cytidine deamination IDA 16378963
GO:0010529 negative regulation of transposition IDA 16527742
GO:0016032 viral process TAS --
GO:0016553 base conversion or substitution editing TAS 17121840
genes like me logo Genes that share ontologies with APOBEC3G: view

Compounds for APOBEC3G Gene

(8) Novoseek inferred chemical compound relationships for APOBEC3G Gene

Compound -log(P) Hits PubMed IDs
cytidine 93.5 44
cytosine 69.8 20
deoxyuridine 63.1 2
deoxycytidine 63 4
poly(i-c) 45.3 1
genes like me logo Genes that share compounds with APOBEC3G: view

Transcripts for APOBEC3G Gene

Unigene Clusters for APOBEC3G Gene

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC3G Gene

No ASD Table

Relevant External Links for APOBEC3G Gene

GeneLoc Exon Structure for
APOBEC3G
ECgene alternative splicing isoforms for
APOBEC3G

Expression for APOBEC3G Gene

mRNA expression in normal human tissues for APOBEC3G Gene

mRNA differential expression in normal tissues according to GTEx for APOBEC3G Gene

This gene is overexpressed in Whole Blood (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APOBEC3G Gene

SOURCE GeneReport for Unigene cluster for APOBEC3G Gene Hs.660143

mRNA Expression by UniProt/SwissProt for APOBEC3G Gene

Q9HC16-ABC3G_HUMAN
Tissue specificity: Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines; no expression detected in permissive lymphoid and non-lymphoid cell lines. Exists only in the LMM form in peripheral blood-derived resting CD4 T-cells and monocytes, both of which are refractory to HIV-1 infection. LMM is converted to a HMM complex when resting CD4 T-cells are activated or when monocytes are induced to differentiate into macrophages. This change correlates with increased susceptibility of these cells to HIV-1 infection.
genes like me logo Genes that share expressions with APOBEC3G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for APOBEC3G Gene

Orthologs for APOBEC3G Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOBEC3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOBEC3G 35
  • 98.35 (n)
  • 95.57 (a)
APOBEC3G 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOBEC3A 36
  • 51 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for APOBEC3G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOBEC3G Gene

ENSEMBL:
Gene Tree for APOBEC3G (if available)
TreeFam:
Gene Tree for APOBEC3G (if available)

Paralogs for APOBEC3G Gene

Selected SIMAP similar genes for APOBEC3G Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for APOBEC3G Gene

genes like me logo Genes that share paralogs with APOBEC3G: view

Variants for APOBEC3G Gene

Sequence variations from dbSNP and Humsavar for APOBEC3G Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs14888 -- 39,087,646(-) TTGAG(C/T)ACAAT utr-variant-3-prime
rs1139723 -- 39,076,199(+) gatcc(A/G)cctgt upstream-variant-2KB
rs1139724 -- 39,076,204(+) gcctg(C/T)ctcag upstream-variant-2KB
rs2011861 -- 39,084,658(+) ATTCC(C/T)CAGTG intron-variant
rs2011869 -- 39,084,692(+) GGGAA(A/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOBEC3G Gene

Variant ID Type Subtype PubMed ID
nsv834196 CNV Loss 17160897
esv2724243 CNV Deletion 23290073
nsv915085 CNV Gain 21882294
nsv510807 CNV Loss 20534489
nsv915086 CNV Gain 21882294
nsv834197 CNV Gain 17160897
dgv4972n71 CNV Gain 21882294
nsv915088 CNV Loss 21882294

Relevant External Links for APOBEC3G Gene

HapMap Linkage Disequilibrium report
APOBEC3G
Human Gene Mutation Database (HGMD)
APOBEC3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3G Gene

Disorders for APOBEC3G Gene

(1) University of Copenhagen DISEASES for APOBEC3G Gene

(8) Novoseek inferred disease relationships for APOBEC3G Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 71.8 53
retrovirus infections 47.5 1
hepatitis b 31 7
hiv infections 30.1 6
aids 27.9 5

Relevant External Links for APOBEC3G

Genetic Association Database (GAD)
APOBEC3G
Human Genome Epidemiology (HuGE) Navigator
APOBEC3G
genes like me logo Genes that share disorders with APOBEC3G: view

No data available for UniProtKB/Swiss-Prot for APOBEC3G Gene

Publications for APOBEC3G Gene

  1. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. (PMID: 12167863) Sheehy A.M. … Malim M.H. (Nature 2002) 3 4 23
  2. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. (PMID: 12808466) Mangeat B. … Trono D. (Nature 2003) 3 4 23
  3. HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. (PMID: 14527406) Stopak K. … Greene W.C. (Mol. Cell 2003) 3 4 23
  4. The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. (PMID: 14528300) Sheehy A.M. … Malim M.H. (Nat. Med. 2003) 3 4 23
  5. HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. (PMID: 14528301) Marin M. … Kabat D. (Nat. Med. 2003) 3 4 23

Products for APOBEC3G Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antiviral Response in human,mouse,rat
    • HIV Host Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate APOBEC3G
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for APOBEC3G
    • Block miRNA regulation of APOBEC3G using miScript Target Protectors

    Sources for APOBEC3G Gene

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