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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOBEC3G Gene

protein-coding   GIFtS: 61
GCID: GC22P039437

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like...

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G1 2     bK150C2.72
CEM152 3 5     dJ494G10.12
Deoxycytidine Deaminase2 3     DNA DC->DU Editing Enzyme2
A3G2 3     DNA DC->DU-Editing Enzyme APOBEC-3G2
ARCD2 3     Phorbolin-Like Protein MDS0192
ARP-92 3     EC 3.5.4.-3
CEM-152 3     APOBEC-Related Protein3
APOBEC-Related Cytidine Deaminase2 3     FLJ127405
APOBEC-Related Protein 92 3     MDS0195
ARP92     EC 3.5.48
Apolipoprotein B Editing Enzyme Catalytic Polypeptide-Like 3G2     EC 3.5.4.58
Apolipoprotein B MRNA Editing Enzyme Cytidine Deaminase2     

External Ids:    HGNC: 173571   Entrez Gene: 604892   Ensembl: ENSG000002397137   OMIM: 6071135   UniProtKB: Q9HC163   

Export aliases for APOBEC3G gene to outside databases

Previous GC identifers: GC22P035994 GC22P036087 GC22P037716 GC22P037680 GC22P037762 GC22P022442


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOBEC3G Gene:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found
in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins
that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is
thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein
encoded by this gene has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1)
infectivity. (provided by RefSeq, Jul 2008)

GeneCards Summary for APOBEC3G Gene: 
APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G) is a protein-coding gene. Diseases associated with APOBEC3G include hiv type 1, and achromatopsia, and among its related super-pathways are HIV Infection and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include cytidine deaminase activity and RNA binding. An important paralog of this gene is APOBEC3F.

UniProtKB/Swiss-Prot: ABC3G_HUMAN, Q9HC16
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity
against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and
the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense
single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant
detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works
prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded
RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV),
equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May
inhibit the mobility of LTR and non-LTR retrotransposons

Gene Wiki entry for APOBEC3G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOBEC3G gene promoter:
         GR   Max   SREBP-1c   ZID   XBP-1   GR-alpha   C/EBPalpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOBEC3G promoter sequence
   Search SABiosciences Chromatin IP Primers for APOBEC3G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC3G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1-q13.2   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1-q13.2

APOBEC3G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC3G gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039437:  view genomic region     (about GC identifiers)

Start:
39,436,924 bp from pter      End:
39,483,748 bp from pter
Size:
46,825 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ABC3G_HUMAN, Q9HC16 (See protein sequence)
Recommended Name: DNA dC->dU-editing enzyme APOBEC-3G  
Size: 384 amino acids; 46408 Da
Cofactor: Zinc
Subunit: Homodimer. Homooligomer. Can bind RNA to form ribonucleoprotein complexes of high-molecular-mass (HMM) or
low-molecular-mass (LMM). HMM is inactive and heterogeneous in protein composition because of binding
nonselectively to cellular RNAs, which in turn are associated with variety of cellular proteins. The LMM form
which is enzymatically active has few or no RNAs associated. Its ability to form homooligomer is distinct from
its ability to assemble into HMM. Interacts with APOBEC3B, APOBEC3F, MOV10, AGO2, EIF4E, EIF4ENIF1, DCP2 and DDX6
in an RNA-dependent manner. Interacts with AGO1, AGO3 and PKA/PRKACA. Interacts with HIV-1 VIF and reverse
transcriptase/ribonuclease H. Interacts with hepatitis B virus capsid protein
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic. Small amount are found in
the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 VIF
Miscellaneous: Accumulation of APOBEC3G induced non-lethal hypermutation could contribute to the genetic variation
of primate lentiviral populations
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 22
Sequence caution: Sequence=CAB45274.1; Type=Erroneous gene model prediction;
6/8 PDB 3D structures from and Proteopedia for APOBEC3G (see all 8):
2JYW (3D)        2KBO (3D)        2KEM (3D)        3E1U (3D)        3IQS (3D)        3IR2 (3D)    
Secondary accessions: B2RDR9 Q45F02 Q5TF77 Q7Z2N1 Q7Z2N4 Q9H9H8
Alternative splicing: 2 isoforms:  Q9HC16-1   Q9HC16-3   (May be due to a competing donor splice site)

Explore the universe of human proteins at neXtProt for APOBEC3G: NX_Q9HC16

Explore proteomics data for APOBEC3G at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated in the presence of HIV-1 VIF. Association with VIF targets the protein for proteolysis by the
    ubiquitin-dependent proteasome pathway
  • UniProtKB: Phosphorylation at Thr-32 reduces its binding to HIV-1 VIF and subsequent ubiquitination and degradation thus
    promoting its antiviral activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HC16

  • 4/12 DME Specific Peptides for APOBEC3G (Q9HC16) (see all 12)
     GRHAELC  FTSWSPC  WLCYEVK  HETYLCY 

    APOBEC3G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APOBEC3G Protein Expression
    REFSEQ proteins: NP_068594.1  
    ENSEMBL proteins: 
     ENSP00000385057   ENSP00000413376  
    Reactome Protein details: Q9HC16
    Human Recombinant Protein Products for APOBEC3G: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for APOBEC3G 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA16699599
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--
    GO:0030529ribonucleoprotein complex IDA16699599

    APOBEC3G for ontologies           About GeneDecksing



    APOBEC3G Antibody Products: 
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    Cloud-Clone Corp. Antibodies for APOBEC3G 
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    LSBio Antibodies in human, mouse, rat for APOBEC3G 

    Assay Products for APOBEC3G: 
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    Cloud-Clone Corp. ELISAs for APOBEC3G 
    Cloud-Clone Corp. CLIAs for APOBEC3G


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    APOBEC: Apolipoprotein B mRNA editing enzymes

    3 InterPro protein domains:
     IPR016193 Cytidine_deaminase-like
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR013158 APOBEC_N

    Graphical View of Domain Structure for InterPro Entry Q9HC16

    ProtoNet protein and cluster: Q9HC16

    1 Blocks protein domain: IPB007904 APOBEC-like

    UniProtKB/Swiss-Prot: ABC3G_HUMAN, Q9HC16
    Domain: The CMP/dCMP deaminase zinc-binding 1 domain mediates RNA binding, RNA-dependent oligomerization and
    virion incorporation whereas the CMP/dCMP deaminase zinc-binding 2 domain confers deoxycytidine deaminase
    activity and substrate sequence specificity (PubMed:17020885)
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family
    Similarity: Contains 2 CMP/dCMP deaminase zinc-binding domains


    APOBEC3G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABC3G_HUMAN, Q9HC16
    Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
    retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity
    against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and
    the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense
    single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant
    detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works
    prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
    Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded
    RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV),
    equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May
    inhibit the mobility of LTR and non-LTR retrotransposons
    Catalytic activity: Deoxycytidine + H(2)O = deoxyuridine + NH(3)
    Enzyme regulation: Assembly into ribonucleoprotein complexes of high-molecular-mass (HMM) inhibits its enzymatic
    activity. Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents its
    incorporation into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination
    and subsequent degradation by the 26S proteasome. Can also be neutralized by simian immunodeficiency virus sooty
    mangabey monkey virus (SIV-sm) and chimpanzee immunodeficiency virus (SIV-cpz) VIF
    Induction: Up-regulated by IFN-alpha

         Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.52 EC 3.5.4.-1

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA11863358
    GO:0003824catalytic activity ----
    GO:0004126cytidine deaminase activity TAS17121840
    GO:0005515protein binding IPI16699599
    GO:0008270zinc ion binding IDA11863358
         
    APOBEC3G for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for APOBEC3G:
     Increased cell death in breast 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for APOBEC3G 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOBEC3G 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOBEC3G 

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC3G


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APOBEC3G About                                                                                                See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Infection0.61
    Host Interactions of HIV factors0.60
    2CDK-mediated phosphorylation and removal of Cdc6
    Vif-mediated degradation of APOBEC3G0.89
    3Integration of viral DNA into host genomic DNA
    APOBEC3G mediated resistance to HIV-1 infection0.60
    4Disease
    Disease
    5Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for APOBEC3G
        Integrated Breast Cancer Pathway

    5        Reactome Pathways for APOBEC3G
        Vif-mediated degradation of APOBEC3G
    APOBEC3G mediated resistance to HIV-1 infection
    HIV Infection
    Disease
    Host Interactions of HIV factors



    APOBEC3G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APOBEC3G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for APOBEC3G (Q9HC162, 3 ENSP000003850574) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTNP212462, 3MINT-65551 I2D: score=5 
    APOBEC3FQ8IUX43, ENSP000003097494I2D: score=1 STRING: ENSP00000309749
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    HSPA4P349323, ENSP000003029614I2D: score=1 STRING: ENSP00000302961
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002230positive regulation of defense response to virus by host IDA17121840
    GO:0009972cytidine deamination IDA16378963
    GO:0010529negative regulation of transposition IDA16527742
    GO:0016032viral process TAS--
    GO:0016553base conversion or substitution editing TAS17121840

    APOBEC3G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOBEC3G for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOBEC3G (ABC3G)

    8 Novoseek inferred chemical compound relationships for APOBEC3G gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 93.5 58 19304304 (3), 15121899 (3), 17121840 (2), 19684020 (2) (see all 35)
    cytosine 69.8 23 17167839 (6), 15647250 (3), 17440614 (2), 17038330 (2) (see all 10)
    deoxyuridine 63.1 3 14528300 (1), 15054139 (1)
    deoxycytidine 63 5 14528300 (1), 15054139 (1), 15297452 (1), 17110377 (1)
    poly(i-c) 45.3 2 16751646 (1)
    zinc 25.1 2 14614829 (1)
    lysine 0 2 14999100 (1)
    aspartate 0 2 14999100 (1)

    Search CenterWatch for drugs/clinical trials and news about APOBEC3G / ABC3G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APOBEC3G gene: 
    NM_021822.3  

    Unigene Cluster for APOBEC3G:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
    Hs.660143  [show with all ESTs]
    Unigene Representative Sequence: BM919047
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407997(uc003awx.3) ENST00000463934 ENST00000480000 ENST00000461827
    ENST00000486357 ENST00000494150(uc003awy.3) ENST00000481958 ENST00000452957(uc021wpr.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB266487.1 AF182420.1 AK310279.1 AK315650.1 BC009683.1 BC024268.1 CR456472.1 JF262036.1 

    13 DOTS entries:

    DT.311082  DT.95174104  DT.91799503  DT.120661955  DT.100796728  DT.95174106  DT.95174108  DT.100769042 
    DT.120661940  DT.95174105  DT.120661950  DT.456333  DT.100740775 

    24/139 AceView cDNA sequences (see all 139):

    CR611013 BX424680 CR619121 AI468964 BM453115 BM127250 AA318561 BX357583 
    NM_021822 AI401777 CB528973 BU752847 AF182420 BM918076 CR456472 AA594960 
    AI864114 CA422242 BC024268 BQ016605 BI827663 AW964236 AI131088 CK906147 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOBEC3G expression in normal human tissues (normalized intensities)      APOBEC3G embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGCTGTG
    APOBEC3G Expression
    About this image


    APOBEC3G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             reticulocytes   
     
     Lymph (Hematopoietic System)
             LYMPH NODE   

    See APOBEC3G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOBEC3G

    SOURCE GeneReport for Unigene cluster: Hs.660143

    UniProtKB/Swiss-Prot: ABC3G_HUMAN, Q9HC16
    Tissue specificity: Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also
    expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines; no expression
    detected in permissive lymphoid and non-lymphoid cell lines. Exists only in the LMM form in peripheral
    blood-derived resting CD4 T-cells and monocytes, both of which are refractory to HIV-1 infection. LMM is
    converted to a HMM complex when resting CD4 T cells are activated or when monocytes are induced to differentiate
    into macrophages. This change correlates with increased susceptibility of these cells to HIV-1 infection

        SABiosciences Expression via Pathway-Focused PCR Arrays including APOBEC3G: 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for APOBEC3G gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    --
    48(a)
    30(a)
    many ↔ many
    many ↔ many
    10(25918046-25918970)
    JH373534.1(10153-31761)


    ENSEMBL Gene Tree for APOBEC3G (if available)
    TreeFam Gene Tree for APOBEC3G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOBEC3G gene
    APOBEC3F2  APOBEC12  APOBEC22  APOBEC3B2  APOBEC3D2  APOBEC3C2  APOBEC3A2  APOBEC3H2  
    AICDA2  
    11 SIMAP similar genes for APOBEC3G using alignment to 4 protein entries:     ABC3G_HUMAN (see all proteins):
    APOBEC3A    APOBEC3B    APOBEC3F    AID    AICDA    APOBEC3C
    bK150C2.9    APOBEC3D    APOBEC3DE    APOBEC3H    APOBEC2

    APOBEC3G for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for APOBEC3G
    PGOHUM00000258645


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/400 SNPs in APOBEC3G are shown (see all 400)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473836011,2
    --39471027(+) TTCATA/GGCAAT 1 -- us2k10--------
    rs775327071,2
    C--39471100(+) CACTT-/AAAACA 1 -- us2k10--------
    rs1896156511,2
    --39471101(+) CACTTA/CAACAG 1 -- us2k10--------
    rs1134428141,2
    C--39471144(+) TTTTGC/TTCTAG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs96229211,2
    H--39471199(+) acctcA/Tcccag 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 420
    rs1166482141,2
    F--39471216(+) GACACG/AGAGTA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1819417981,2
    --39471261(+) TTCCCC/TGAGCA 1 -- us2k10--------
    rs1847335061,2
    --39471280(+) ATTTCA/TGTAAC 1 -- us2k10--------
    rs1883693881,2
    --39471336(+) GTTTAC/TAGACC 1 -- us2k10--------
    rs1807333921,2
    --39471425(+) TCCACC/TGCAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for APOBEC3G (39436924 - 39483748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for APOBEC3G:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724243CNV Deletion23290073
    nsv834196CNV Loss17160897
    nsv915088CNV Loss21882294
    nsv510807CNV Loss20534489
    nsv915086CNV Gain21882294
    nsv915085CNV Gain21882294
    nsv834197CNV Gain17160897
    dgv4972n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): APOBEC3G
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607113    OMIM disorders: --

    19 diseases for APOBEC3G:    About MalaCards
    hiv type 1    achromatopsia    human immunodeficiency virus infectious disease    human t-cell leukemia virus type 1
    vaccinia    hepatitis b    albinism    t-cell leukemia
    hepatitis    hepatitis c    influenza    anemia
    retinitis    colorectal cancer    leukemia    prostate cancer
    neuronitis    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for APOBEC3G:
    Human immunodeficiency virus infectious disease

    APOBEC3G for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    8 Novoseek inferred disease relationships for APOBEC3G gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 71.8 68 19776130 (2), 18684817 (2), 19684020 (2), 19004939 (2) (see all 46)
    retrovirus infections 47.5 1 17078485 (1)
    hepatitis b 31 8 17167839 (2), 18420796 (1), 18336343 (1), 18806783 (1) (see all 6)
    hiv infections 30.1 6 17067930 (1), 15723516 (1), 16418394 (1), 17917584 (1) (see all 6)
    aids 27.9 7 15609224 (2), 12167863 (1), 16943852 (1), 14528300 (1)
    tumors 1.63 2 19027180 (1), 15297452 (1)
    virus infection 0 1 16720547 (1)
    necrosis 0 2 19027180 (1), 15297452 (1)

    Genetic Association Database (GAD): APOBEC3G
    Human Genome Epidemiology (HuGE) Navigator: APOBEC3G (6 documents)

    Export disorders for APOBEC3G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOBEC3G gene, integrated from 9 sources (see all 454):
    (articles sorted by number of sources associating them with APOBEC3G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PubMed id 11863358)1, 2, 3 Jarmuz A....Navaratnam N. (2002)
    2. APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma vira l load. (PubMed id 19996938)1, 4, 9 Reddy K....Ndung'u T. (2010)
    3. HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. (PubMed id 14527406)1, 2, 9 Stopak K.... Greene W.C. (2003)
    4. Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort. (PubMed id 15609224)1, 4, 9 Do H....Zagury J.F. (2005)
    5. Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G. (PubMed id 19153609)1, 2, 9 Furukawa A....Katahira M. (2009)
    6. A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion. (PubMed id 15054139)1, 2, 9 Xu H....Pathak V.K. (2004)
    7. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. (PubMed id 12808466)1, 2, 9 Mangeat B.... Trono D. (2003)
    8. The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. (PubMed id 14528300)1, 2, 9 Sheehy A.M.... Malim M.H. (2003)
    9. [The associations between polymorphisms of APOBEC3G and different outcomes of persistent HBV infection] (PubMed id 18647522)1, 4, 9 Tian D....Cui J.J. (2008)
    10. Absence of H186R polymorphism in exon 4 of the APOBEC3G gene among North Indian individuals. (PubMed id 18652534)1, 4, 9 Rathore A....Dhole T.N. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60489 HGNC: 17357 AceView: APOBEC3G Ensembl:ENSG00000239713 euGenes: HUgn60489
    ECgene: APOBEC3G H-InvDB: APOBEC3G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOBEC3G Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/apobec3g/
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt045.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APOBEC3G gene:
    Search GeneIP for patents involving APOBEC3G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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