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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOBEC3G Gene

protein-coding   GIFtS: 60
GCID: GC22P039437

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like...
 Explore 17 diseases affiliated with
APOBEC3G via
MalaCards
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 Human Malady Compendium 
Biological research products
for APOBEC3G    

Aliases
for APOBEC3G gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G1 2     MDS0191 5
CEM151 2 3 5     ARP92
BK150C2.71     Apolipoprotein B MRNA Editing Enzyme Cytidine Deaminase2
DJ494G10.11     DNA DC->DU Editing Enzyme2
Deoxycytidine Deaminase2 3     DNA DC->DU-Editing Enzyme APOBEC-3G2
ARCD2 3     Phorbolin-Like Protein MDS0192
ARP-92 3     A3G3
CEM-152 3     EC 3.5.4.143
APOBEC-Related Cytidine Deaminase2 3     APOBEC-Related Protein3
APOBEC-Related Protein 92 3     EC 3.5.48
FLJ127401 5     EC 3.5.4.58

External Ids:    HGNC: 173571   Entrez Gene: 604892   Ensembl: ENSG000002397137   OMIM: 6071135   UniProtKB: Q9HC163   

Export aliases for APOBEC3G gene to outside databases

Previous GC identifers: GC22P035994 GC22P036087 GC22P037716 GC22P037680 GC22P037762 GC22P022442


Summaries
for APOBEC3G gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for APOBEC3G:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a
cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are
structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the
proteins may be RNA editing enzymes and have roles in growth or cell cycle control. The protein encoded by this gene
has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: ABC3G_HUMAN, Q9HC16
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon
mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient
HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse
transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading
to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the
proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together
exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not
deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian
immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic
MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons

Gene Wiki entry for APOBEC3G


Genomic Views
for APOBEC3G gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOBEC3G gene promoter:
         GR   Max   SREBP-1c   ZID   XBP-1   GR-alpha   C/EBPalpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOBEC3G promoter sequence
   Search SABiosciences Chromatin IP Primers for APOBEC3G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC3G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1-q13.2   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1-q13.2

APOBEC3G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC3G gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039437:  view genomic region     (about GC identifiers)

Start:
 39,436,924 bp from pter      End:
 39,483,748 bp from pter
Size:
 46,825 bases      Orientation:
 plus strand

Proteins
for APOBEC3G gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ABC3G_HUMAN, Q9HC16 (See protein sequence)
Recommended Name: DNA dC->dU-editing enzyme APOBEC-3G  
Size: 384 amino acids; 46408 Da
Cofactor: Zinc
Subunit: Homodimer. Homooligomer. Can bind RNA to form ribonucleoprotein complexes of high-molecular-mass (HMM) or
low-molecular-mass (LMM). HMM is inactive and heterogeneous in protein composition because of binding nonselectively
to cellular RNAs, which in turn are associated with variety of cellular proteins. The LMM form which is enzymatically
active has few or no RNAs associated. Its ability to form homooligomer is distinct from its ability to assemble into
HMM. Interacts with APOBEC3B, APOBEC3F, MOV10, EIF2C2/AGO2, EIF4E, EIF4ENIF1, DCP2 and DDX6 in an RNA-dependent
manner. Interacts with EIF2C1/AGO1, EIF2C3/AGO3 and PKA/PRKACA. Interacts with HIV-1 VIF and reverse
transcriptase/ribonuclease H. Interacts with hepatitis B virus capsid protein
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic. Small amount are found in the
nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 VIF
Miscellaneous: Accumulation of APOBEC3G induced non-lethal hypermutation could contribute to the genetic variation of
primate lentiviral populations
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 22
Sequence caution: Sequence=CAB45274.1; Type=Erroneous gene model prediction;
6/8 PDB 3D structures from and Proteopedia for APOBEC3G (see all 8):
2JYW (3D)        2KBO (3D)        2KEM (3D)        3E1U (3D)        3IQS (3D)        3IR2 (3D)    
Secondary accessions: B2RDR9 Q45F02 Q5TF77 Q7Z2N1 Q7Z2N4 Q9H9H8
Alternative splicing: 2 isoforms:  Q9HC16-1   Q9HC16-3   (May be due to a competing donor splice site)

Explore the universe of human proteins at neXtProt for APOBEC3G: NX_Q9HC16

Post-translational modifications:

  • Ubiquitinated in the presence of HIV-1 VIF. Association with VIF targets the protein for proteolysis by the
    • ubiquitin-dependent proteasome pathway1
  • Phosphorylation at Thr-32 reduces its binding to HIV-1 VIF and subsequent ubiquitination and degradation thus promoting
    • its antiviral activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HC16

    • 4/12 DME Specific Peptides for APOBEC3G (Q9HC16) (see all 12)
     GRHAELC  FTSWSPC  WLCYEVK  HETYLCY 

    APOBEC3G Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_068594.1  
    ENSEMBL proteins: 
     ENSP00000385057   ENSP00000413376  
    Reactome Protein details: Q9HC16
    Human Recombinant Protein Products: 
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    Novus Biologicals APOBEC3G Proteins
    Novus Biologicals APOBEC3G Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for APOBEC3G

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--
    GO:0030529ribonucleoprotein complex IDA16699599


    APOBEC3G for ontologies           About GeneDecksing



    APOBEC3G Antibody Products: 
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    Abcam antibodies for APOBEC3G 
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    ThermoFisher Antibodies for APOBEC3G

    Assay Products for APOBEC3G: 
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    Uscn ELISAs and CLIAs for APOBEC3G

    Protein Domains /
    Families
    for APOBEC3G gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    APOBEC3G for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016193 Cytidine_deaminase-like
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR013158 APOBEC_N

    Graphical View of Domain Structure for InterPro Entry Q9HC16

    ProtoNet protein and cluster: Q9HC16

    1 Blocks protein family: IPB007904 APOBEC-like

    UniProtKB/Swiss-Prot: ABC3G_HUMAN, Q9HC16
    Domain: The CMP/dCMP deaminase zinc-binding 1 domain mediates RNA binding, RNA-dependent oligomerization and virion
    incorporation whereas the CMP/dCMP deaminase zinc-binding 2 domain confers deoxycytidine deaminase activity and
    substrate sequence specificity (PubMed:17020885)
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family
    Similarity: Contains 2 CMP/dCMP deaminase zinc-binding domains


    Function
    for APOBEC3G gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ABC3G_HUMAN, Q9HC16
    Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon
    mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient
    HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse
    transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading
    to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the
    proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together
    exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not
    deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian
    immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic
    MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons
    Catalytic activity: Deoxycytidine + H(2)O = deoxyuridine + NH(3)
    Enzyme regulation: Assembly into ribonucleoprotein complexes of high-molecular-mass (HMM) inhibits its enzymatic
    activity. Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents its
    incorporation into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and
    subsequent degradation by the 26S proteasome. Can also be neutralized by simian immunodeficiency virus sooty mangabey
    monkey virus (SIV-sm) and chimpanzee immunodeficiency virus (SIV-cpz) VIF
    Induction: Up-regulated by IFN-alpha

    Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.52 EC 3.5.4.141

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC3G

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA11863358
    GO:0004126cytidine deaminase activity TAS17121840
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IDA11863358
    GO:0042803protein homodimerization activity NAS11863358


    APOBEC3G for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for APOBEC3G:
     Increased cell death in breast 


    Pathways & Interactions
    for APOBEC3G gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1HIV Infection
    		HIV Infection1.00
    		Host Interactions of HIV factors0.64
    2Ubiquitinated Orc1 is degraded by the proteasome
    		Vif-mediated degradation of APOBEC3G0.89
    		Proteosome-mediated degradation of APOBEC3G0.89
    3Disease
    		Disease1.00
    4Integrated Breast Cancer Pathway
    		Integrated Breast Cancer Pathway1.00
    5Integration of viral DNA into host genomic DNA
    		APOBEC3G mediated resistance to HIV-1 infection0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for APOBEC3G 
        Integrated Breast Cancer Pathway

    5/6        Reactome Pathways for APOBEC3G (see all 6)
        Vif-mediated degradation of APOBEC3G
    APOBEC3G mediated resistance to HIV-1 infection
    HIV Infection
    Disease
    Host Interactions of HIV factors



    APOBEC3G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APOBEC3G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for APOBEC3G (Q9HC162, 3 ENSP000003850574) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTNP212462, 3MINT-65551 I2D: score=5 
    APOBEC3FQ8IUX43, ENSP000003097494I2D: score=1 STRING: ENSP00000309749
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    HSPA4P349323, ENSP000003029614I2D: score=1 STRING: ENSP00000302961
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002230positive regulation of defense response to virus by host IDA17121840
    GO:0009972cytidine deamination IDA16378963
    GO:0010529negative regulation of transposition IDA16527742
    GO:0016032viral reproduction TAS--
    GO:0016553base conversion or substitution editing TAS17121840


    APOBEC3G for ontologies           About GeneDecksing



    Drugs & Compounds
    for APOBEC3G gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOBEC3G for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOBEC3G
    8 Novoseek chemical compound relationships for APOBEC3G gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 93.5 58 19304304 (3), 15121899 (3), 17121840 (2), 19684020 (2) (see all 35)
    cytosine 69.8 23 17167839 (6), 15647250 (3), 17440614 (2), 17038330 (2) (see all 10)
    deoxyuridine 63.1 3 14528300 (1), 15054139 (1)
    deoxycytidine 63 5 14528300 (1), 15054139 (1), 15297452 (1), 17110377 (1)
    poly(i-c) 45.3 2 16751646 (1)
    zinc 25.1 2 14614829 (1)
    lysine 0 2 14999100 (1)
    aspartate 0 2 14999100 (1)

    Search CenterWatch for drugs/clinical trials and news about APOBEC3G / ABC3G 

    Transcripts
    for APOBEC3G gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APOBEC3G gene: 
    NM_021822.3  

    Unigene Cluster for APOBEC3G:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
    Hs.660143  [show with all ESTs]
    Unigene Representative Sequence: BM919047
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407997(uc003awx.3) ENST00000463934 ENST00000480000 ENST00000461827
    ENST00000486357 ENST00000494150(uc003awy.3) ENST00000481958 ENST00000452957(uc021wpr.1)


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    Inhib. RNA
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    Additional cDNA sequence: 

    AB266487.1 AF182420.1 AK310279.1 AK315650.1 BC009683.1 BC024268.1 CR456472.1 JF262036.1 

    13 DOTS entries:

    DT.311082  DT.95174104  DT.91799503  DT.120661955  DT.100796728  DT.95174106  DT.95174108  DT.100769042 
    DT.120661940  DT.95174105  DT.120661950  DT.456333  DT.100740775 

    24/139 AceView cDNA sequences (see all 139):

    BF794569 AI131088 BC024268 CR619121 BX357583 CK906147 AW964236 NM_021822 
    BU752847 AI468964 AA318561 CB528973 AF182420 BM127250 CR456472 AA594960 
    BM748036 BQ016605 BM918076 BM453115 BI827663 AI401777 AI864114 BF726065 

    GeneLoc Exon Structure


    Expression
    for APOBEC3G gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOBEC3G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAGCTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    APOBEC3G expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See APOBEC3G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOBEC3G

    SOURCE GeneReport for Unigene cluster: Hs.660143

    UniProtKB/Swiss-Prot: ABC3G_HUMAN, Q9HC16
    Tissue specificity: Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also
    expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines; no expression detected
    in permissive lymphoid and non-lymphoid cell lines. Exists only in the LMM form in peripheral blood-derived resting
    CD4 T-cells and monocytes, both of which are refractory to HIV-1 infection. LMM is converted to a HMM complex when
    resting CD4 T cells are activated or when monocytes are induced to differentiate into macrophages. This change
    correlates with increased susceptibility of these cells to HIV-1 infection

        SABiosciences Expression via Pathway-Focused PCR Arrays including APOBEC3G: 
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              Antiviral Response in human mouse rat

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    Orthologs
    for APOBEC3G gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for APOBEC3G gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia APOBEC16
    		 --
    		 26(a)
    		 possible ortholog
    		 3(98130519-98131040)


    ENSEMBL Gene Tree for APOBEC3G (if available)
    TreeFam Gene Tree for APOBEC3G (if available) 

    Paralogs
    for APOBEC3G gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOBEC3G gene
    APOBEC3D2  APOBEC3F2  APOBEC12  APOBEC22  APOBEC3B2  APOBEC3C2  APOBEC3H2  APOBEC3A2  
    AICDA2  
    11 SIMAP similar genes for APOBEC3G using alignment to 3 protein entries:     ABC3G_HUMAN (see all proteins):
    APOBEC3A    APOBEC3B    APOBEC3F    AID    AICDA    APOBEC3C
    bK150C2.9    APOBEC3H    APOBEC3D    APOBEC3DE    APOBEC2

    APOBEC3G for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for APOBEC3G
    PGOHUM00000258645


    Genomic Variants
    for APOBEC3G gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/305 NCBI SNPs in APOBEC3G are shown (see all 305)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1473836011,2
    		--39471027(+) TTCATA/GGCAAT 1 -- us2k10--------
    rs775327071,2
    		C,--39471100(+) CACTT-/AAAACA 1 -- us2k10--------
    rs1896156511,2
    		--39471101(+) CACTTA/CAACAG 1 -- us2k10--------
    rs96229211,2
    		H--39471199(+) acctcA/Tcccag 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 420
    rs1166482141,2
    		F,--39471216(+) GACACG/AGAGTA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1819417981,2
    		--39471261(+) TTCCCC/TGAGCA 1 -- us2k10--------
    rs1847335061,2
    		--39471280(+) ATTTCA/TGTAAC 1 -- us2k10--------
    rs1883693881,2
    		--39471336(+) GTTTAC/TAGACC 1 -- us2k10--------
    rs1807333921,2
    		--39471425(+) TCCACC/TGCAAT 1 -- us2k10--------
    rs1867027211,2
    		--39471512(+) GATGGA/CGTCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for APOBEC3G (39436924 - 39483748 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for APOBEC3G: --
    Human Gene Mutation Database (HGMD): APOBEC3G

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    Disorders / Diseases
    for APOBEC3G gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APOBEC3G for disorders           About GeneDecksing

    OMIM gene information: 607113    OMIM disorders: --

    17 diseases for APOBEC3G:    About MalaCards
    human t-cell leukemia virus type 1    immunodeficiency    human immunodeficiency virus infectious disease    achromatopsia
    hepatitis b    t-cell leukemia    albinism    hepatitis c
    vaccinia    hepatitis    influenza    colorectal cancer
    leukemia    anemia    retinitis    neuronitis
    hiv type 1

    1 disease from the University of Copenhagen DISEASES database for APOBEC3G:
    Human immunodeficiency virus infectious disease

    8 Novoseek disease relationships for APOBEC3G gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 71.8 68 19776130 (2), 18684817 (2), 19684020 (2), 19004939 (2) (see all 46)
    retrovirus infections 47.5 1 17078485 (1)
    hepatitis b 31 8 17167839 (2), 18420796 (1), 18336343 (1), 18806783 (1) (see all 6)
    hiv infections 30.1 6 17067930 (1), 15723516 (1), 16418394 (1), 17917584 (1) (see all 6)
    aids 27.9 7 15609224 (2), 12167863 (1), 16943852 (1), 14528300 (1)
    tumors 1.63 2 19027180 (1), 15297452 (1)
    virus infection 0 1 16720547 (1)
    necrosis 0 2 19027180 (1), 15297452 (1)

    Genetic Association Database (GAD): APOBEC3G
    Human Genome Epidemiology (HuGE) Navigator: APOBEC3G (6 documents)

    Export disorders for APOBEC3G gene to outside databases

    Publications
    for APOBEC3G gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOBEC3G gene, integrated from 9 sources (see all 440):
    (articles sorted by number of sources associating them with APOBEC3G)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PubMed id 11863358)1, 2, 3 Jarmuz A....Navaratnam N. (2002)
    2. HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. (PubMed id 14527406)1, 2, 9 Stopak K.... Greene W.C. (2003)
    3. Exhaustive genotyping of the CEM15 (APOBEC3G) gene and absence of association with AIDS progression in a French cohort. (PubMed id 15609224)1, 4, 9 Do H....Zagury J.F. (2005)
    4. Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G. (PubMed id 19153609)1, 2, 9 Furukawa A....Katahira M. (2009)
    5. A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion. (PubMed id 15054139)1, 2, 9 Xu H....Pathak V.K. (2004)
    6. Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. (PubMed id 12808466)1, 2, 9 Mangeat B.... Trono D. (2003)
    7. The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. (PubMed id 14528300)1, 2, 9 Sheehy A.M.... Malim M.H. (2003)
    8. Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif. (PubMed id 18836454)1, 2, 9 Shirakawa K....Uchiyama T. (2008)
    9. HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. (PubMed id 14528301)1, 2, 9 Marin M.... Kabat D. (2003)
    10. Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G. (PubMed id 18288108)1, 2, 9 Chen K.M....Matsuo H. (2008)

    External Searches for APOBEC3G gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing APOBEC3G gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60489 HGNC: 17357 AceView: APOBEC3G Ensembl:ENSG00000239713 euGenes: HUgn60489
    ECgene: APOBEC3G H-InvDB: APOBEC3G

    Other Databases showing APOBEC3G gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing APOBEC3G gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOBEC3G Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/apobec3g/
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt045.shtml

    Intellectual Property
    for APOBEC3G gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for APOBEC3G gene:
    Search GeneIP for patents involving APOBEC3G

    GeneCards and IP:
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