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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOBEC3F Gene

protein-coding   GIFtS: 55
GCID: GC22P039436

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3F1 2     Apolipoprotein B MRNA Editing Enzyme Cytidine Deaminase2
Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 3F2 3     DNA DC->DU-Editing Enzyme APOBEC-3F2
A3F2 3     Induced Upon T-Cell Activation2
ARP82     EC 3.5.4.-3
BK150C2.4.MRNA2     EC 3.5.48
KA62     

External Ids:    HGNC: 173561   Entrez Gene: 2003162   Ensembl: ENSG000001283947   OMIM: 6089935   UniProtKB: Q8IUX43   

Export aliases for APOBEC3F gene to outside databases

Previous GC identifers: GC22P036031 GC22P036051 GC22P037679 GC22P037761 GC22P022404


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOBEC3F Gene:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found
in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins
that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is
thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.
Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq,
Jul 2008)

GeneCards Summary for APOBEC3F Gene: 
APOBEC3F (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F) is a protein-coding gene. Diseases associated with APOBEC3F include chronic fatigue syndrome, and albinism. GO annotations related to this gene include cytidine deaminase activity and RNA binding. An important paralog of this gene is APOBEC3G.

UniProtKB/Swiss-Prot: ABC3F_HUMAN, Q8IUX4
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against
vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the
initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense
single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant
detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works
prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded
RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV),
xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR
retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of
active DNA demethylation

Gene Wiki entry for APOBEC3F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOBEC3F gene promoter:
         Hand1   ZID   E47   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOBEC3F promoter sequence
   Search SABiosciences Chromatin IP Primers for APOBEC3F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC3F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1-q13.2

APOBEC3F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC3F gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039436:  view genomic region     (about GC identifiers)

Start:
39,436,609 bp from pter      End:
39,451,977 bp from pter
Size:
15,369 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ABC3F_HUMAN, Q8IUX4 (See protein sequence)
Recommended Name: DNA dC->dU-editing enzyme APOBEC-3F  
Size: 373 amino acids; 45020 Da
Cofactor: Zinc (By similarity)
Subunit: Binds HIV-1 Vif. In the absence of Vif protein, specifically packaged into HIV-1 virions. Interacts with
APOBEC3G in an RNA-dependent manner. Interacts with AGO1, AGO2 and AGO3
Subcellular location: Cytoplasm. Cytoplasm, P-body
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 22
1 PDB 3D structure from and Proteopedia for APOBEC3F:
4IOU (3D)    
Secondary accessions: B0QYD4 Q45F03 Q6ICH3 Q7Z2N2 Q7Z2N5
Alternative splicing: 3 isoforms:  Q8IUX4-1   Q8IUX4-2   Q8IUX4-3   (May be due to a competing donor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APOBEC3F: NX_Q8IUX4

Explore proteomics data for APOBEC3F at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IUX4

  • 3 DME Specific Peptides for APOBEC3F (Q8IUX4)
     CFLSWFC  WLCYEVK  DSKLQEIL 

    APOBEC3F Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APOBEC3F Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001006667.1  NP_660341.2  

    ENSEMBL proteins: 
     ENSP00000309749   ENSP00000370977  

    Human Recombinant Protein Products for APOBEC3F: 
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    Novus Biologicals APOBEC3F Proteins
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    Cloud-Clone Corp. Proteins for APOBEC3F 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA16699599
    GO:0005737cytoplasm IDA16527742
    GO:0030529ribonucleoprotein complex IDA16699599
    GO:0030895apolipoprotein B mRNA editing enzyme complex TAS17121840

    APOBEC3F for ontologies           About GeneDecksing



    APOBEC3F Antibody Products: 
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    Abcam antibodies for APOBEC3F
    Cloud-Clone Corp. Antibodies for APOBEC3F 
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    LSBio Antibodies in human, mouse, rat for APOBEC3F 

    Assay Products for APOBEC3F: 
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    Cloud-Clone Corp. ELISAs for APOBEC3F 
    Cloud-Clone Corp. CLIAs for APOBEC3F


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    APOBEC: Apolipoprotein B mRNA editing enzymes

    3 InterPro protein domains:
     IPR016193 Cytidine_deaminase-like
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR013158 APOBEC_N

    Graphical View of Domain Structure for InterPro Entry Q8IUX4

    ProtoNet protein and cluster: Q8IUX4

    2 Blocks protein domains:
    IPB002125 Cytidine/deoxycytidylate deaminase
    IPB007904 APOBEC-like


    UniProtKB/Swiss-Prot: ABC3F_HUMAN, Q8IUX4
    Domain: The CMP/dCMP deaminase zinc-binding 1 domain mediates RNA binding, RNA-dependent oligomerization and
    virion incorporation whereas the CMP/dCMP deaminase zinc-binding 2 domain confers deoxycytidine deaminase
    activity and substrate sequence specificity (PubMed:17020885)
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family
    Similarity: Contains 2 CMP/dCMP deaminase zinc-binding domains


    APOBEC3F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABC3F_HUMAN, Q8IUX4
    Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
    retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against
    vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the
    initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense
    single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant
    detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works
    prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
    Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded
    RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV),
    xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR
    retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of
    active DNA demethylation
    Catalytic activity: Cytidine + H(2)O = uridine + NH(3)
    Enzyme regulation: Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents
    its incorporation into progeny virions by both inhibiting its translation and/or by inducing its ubiquitination
    and subsequent degradation by the 26S proteasome
    Induction: Up-regulated by IFN-alpha

         Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA11863358
    GO:0003824catalytic activity ----
    GO:0004126cytidine deaminase activity IDA17121840
    GO:0005515protein binding IPI16699599
    GO:0008270zinc ion binding IDA11863358
         
    APOBEC3F for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for APOBEC3F:
     Decreased viability  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for APOBEC3F 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOBEC3F 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOBEC3F 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC3F


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APOBEC3F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for APOBEC3F (Q8IUX43 ENSP000003097494) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBEC3GQ9HC163, ENSP000003850574I2D: score=1 STRING: ENSP00000385057
    A1CFENSP000002826414STRING: ENSP00000282641
    APOBEC3DENSP000002160994STRING: ENSP00000216099
    UBCENSP000003448184STRING: ENSP00000344818
    ACDENSP000003774964STRING: ENSP00000377496
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002230positive regulation of defense response to virus by host IDA17121840
    GO:0009972cytidine deamination IDA17121840
    GO:0010529negative regulation of transposition IDA16527742
    GO:0016553base conversion or substitution editing IDA17121840
    GO:0045071negative regulation of viral genome replication IDA16378963

    APOBEC3F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOBEC3F for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for APOBEC3F (ABC3F)

    2 Novoseek inferred chemical compound relationships for APOBEC3F gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 88.8 22 17121840 (3), 16201018 (2), 16731937 (1), 16842218 (1) (see all 14)
    cytosine 51 10 15647250 (3), 17038330 (2)

    Search CenterWatch for drugs/clinical trials and news about APOBEC3F / ABC3F

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APOBEC3F gene (2 alternative transcripts): 
    NM_001006666.1  NM_145298.5  

    Unigene Cluster for APOBEC3F:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
    Hs.659809  [show with all ESTs]
    Unigene Representative Sequence: NM_145298
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491387 ENST00000308521(uc011aog.1 uc003aww.3) ENST00000381565(uc003awv.3)
    ENST00000476513
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AK294810.1 BC038808.1 CR456395.1 JF262037.1 U38435.1 

    10 DOTS entries:

    DT.86837797  DT.311082  DT.40259870  DT.91640746  DT.91799503  DT.75134435  DT.95214959  DT.100740775 
    DT.312711  DT.95174104 

    24/142 AceView cDNA sequences (see all 142):

    BQ056344 BQ921509 BF508948 CR456395 BM564332 NM_145298 BX112841 AI217046 
    BX326730 CD656372 BX332251 AI799894 BE892372 BM977965 BF437832 BX388243 
    AI910810 CF142810 AI092348 BX367450 BG744406 BC038808 BG758984 BX331204 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC3F (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17
    SP1:                                                                                -           -                             -                                 
    SP2:              -     -     -     -     -     -     -     -     -     -     -     -           -                             -                                 
    SP3:                          -     -     -     -     -     -     -     -     -     -           -                             -                                 
    SP4:                                -                                                                                                                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for APOBEC3F

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOBEC3F expression in normal human tissues (normalized intensities)      APOBEC3F embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCCCCCCA
    APOBEC3F Expression
    About this image


    APOBEC3F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See APOBEC3F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOBEC3F

    SOURCE GeneReport for Unigene cluster: Hs.659809

    UniProtKB/Swiss-Prot: ABC3F_HUMAN, Q8IUX4
    Tissue specificity: Widely expressed. Highly expressed in ovary

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for APOBEC3F gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia APOBEC3F1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like more 98.48(n)
    96.78(a)
      470275  XM_525658.3  XP_525658.2 


    ENSEMBL Gene Tree for APOBEC3F (if available)
    TreeFam Gene Tree for APOBEC3F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOBEC3F gene
    APOBEC3G2  APOBEC12  APOBEC22  APOBEC3B2  APOBEC3D2  APOBEC3C2  APOBEC3A2  APOBEC3H2  
    AICDA2  
    11 SIMAP similar genes for APOBEC3F using alignment to 3 protein entries:     ABC3F_HUMAN (see all proteins):
    APOBEC3C    APOBEC3D    APOBEC3DE    bK150C2.9    APOBEC3B    APOBEC3G
    AID    AICDA    APOBEC2    APOBEC3A    APOBEC3H

    APOBEC3F for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for APOBEC3F
    PGOHUM00000246587


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/501 SNPs in APOBEC3F are shown (see all 501)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0181464
    ----see VAR_0181462 P L mis40--------
    VAR_0181454
    ----see VAR_0181452 Q L mis40--------
    rs1886293531,2
    --39434749(+) TGCCTC/TCTGGG 2 -- us2k10--------
    rs1928283211,2
    --39434751(+) CCTTCC/TGGGTT 2 -- us2k10--------
    rs1382356631,2
    --39434878(+) GGTCTC/TGAACT 2 -- us2k10--------
    rs1164190391,2
    C,F--39434898(+) CATGCG/CTGTCT 2 -- us2k11Minor allele frequency- C:0.12WA 118
    rs57507261,2
    C,F,A,H--39434907(+) ctgtaC/Tagaaa 2 -- us2k118Minor allele frequency- T:0.49NS EA WA NA CSA 2054
    rs1132611591,2
    C,F--39434968(+) TGCAAC/GTGGGC 2 -- us2k10--------
    rs1134680171,2
    C,F--39435004(+) GGGAGG/ATAAGA 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1913429781,2
    C--39435095(+) GTCACA/CAGGTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for APOBEC3F (39436609 - 39451977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for APOBEC3F (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676044CNV Deletion23128226
    esv2724243CNV Deletion23290073
    esv2673637CNV Deletion23128226
    esv2724242CNV Deletion23290073
    nsv522083CNV Loss19592680
    nsv834196CNV Loss17160897
    nsv915084CNV Loss21882294
    nsv915083CNV Loss21882294
    nsv915085CNV Gain21882294
    nsv915081CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608993    OMIM disorders: --

    8 diseases for APOBEC3F:    About MalaCards
    chronic fatigue syndrome    albinism    hepatitis b    influenza
    retinitis    anemia    hepatitis    leukemia


    APOBEC3F for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for APOBEC3F gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retrovirus infections 62.6 1 17078485 (1)
    immunodeficiency 57.5 9 18598197 (1), 15479843 (1), 16963778 (1), 16912295 (1) (see all 9)


    Export disorders for APOBEC3F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOBEC3F gene, integrated from 9 sources (see all 151):
    (articles sorted by number of sources associating them with APOBEC3F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PubMed id 11863358)1, 2, 3 Jarmuz A....Navaratnam N. (2002)
    2. APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G. (PubMed id 17121840)1, 3, 9 Holmes R.K....Malim M.H. (2007)
    3. A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins. (PubMed id 15152192)1, 2, 9 Wiegand H.L.... Cullen B.R. (2004)
    4. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2, 9 Wichroski M.J....Rana T.M. (2006)
    5. APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ t cells and macrophages. (PubMed id 23097438)1, 2 Chaipan C.... Pathak V.K. (2013)
    6. Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n. (PubMed id 22807680)1, 2 Refsland E.W.... Harris R.S. (2012)
    7. Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1. (PubMed id 21835787)1, 2 Hultquist J.F.... Harris R.S. (2011)
    8. APOBEC3F and APOBEC3G inhibit HIV-1 DNA integration b y different mechanisms. (PubMed id 20219927)1, 2 Mbisa J.L....Pathak V.K. (2010)
    9. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. (PubMed id 18304004)1, 2 Chiu Y.L. and Greene W.C. (2008)
    10. APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. (PubMed id 16527742)1, 2 Chen H....Weitzman M.D. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200316 HGNC: 17356 AceView: APOBEC3F Ensembl:ENSG00000128394 euGenes: HUgn200316
    ECgene: APOBEC3F H-InvDB: APOBEC3F

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOBEC3F Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/apobec3f/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APOBEC3F gene:
    Search GeneIP for patents involving APOBEC3F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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