Aliases for APOBEC3F Gene
Aliases for APOBEC3F Gene
- Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3F 2 3 5
- Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 3F 3 4
- A3F 3 4
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3F 2
- Apolipoprotein B Editing Enzyme Catalytic Polypeptide-Like 3F 3
- Apolipoprotein B MRNA Editing Enzyme Cytidine Deaminase 3
- DNA DC->DU-Editing Enzyme APOBEC-3F 3
External Ids for APOBEC3F Gene
- HGNC: 17356
- Entrez Gene: 200316
- Ensembl: ENSG00000128394
- OMIM: 608993
- UniProtKB: Q8IUX4
Previous GeneCards Identifiers for APOBEC3F Gene
- GC22P036031
- GC22P036051
- GC22P037679
- GC22P037761
- GC22P039436
- GC22P022404
Summaries for APOBEC3F Gene
-
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOBEC3F Gene
APOBEC3F (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3F) is a Protein Coding gene. Diseases associated with APOBEC3F include Ipex Syndrome and Theileriasis. GO annotations related to this gene include poly(A) RNA binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines. An important paralog of this gene is ENSG00000284554.
UniProtKB/Swiss-Prot for APOBEC3F Gene
-
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3F Gene
Genomics for APOBEC3F Gene
Regulatory Elements for APOBEC3F Gene
Enhancers for APOBEC3F Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH22G039039 | 1 | ENCODE | 6.4 | +0.7 | 722 | 2.9 | HDGF ARID4B ZNF2 ZNF121 GLIS2 ZNF143 ZNF263 SP3 SP5 YY2 | APOBEC3G APOBEC3F ENSG00000259421 |
| GH22G039017 | 1 | Ensembl ENCODE dbSUPER | 5.1 | -22.5 | -22532 | 1.5 | CTCF POLR2A POU5F1 ZNF384 ZBTB40 | APOBEC3D APOBEC3C APOBEC3F GC22P039017 GC22P039018 |
| GH22G039063 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 0.3 | +25.7 | 25744 | 5.1 | HDGF TBP PKNOX1 RB1 WRNIP1 RAD21 TCF12 ZNF121 ZNF366 RELB | APOBEC3G ENSG00000259421 APOBEC3F |
| GH22G039019 | 1.1 | ENCODE dbSUPER | 0.4 | -19.3 | -19301 | 3.0 | HDGF PKNOX1 ATF1 NFXL1 ZBTB40 GLIS2 SCRT2 RELB IKZF2 EGR2 | APOBEC3D APOBEC3C APOBEC3F |
| GH22G039031 | 0.9 | Ensembl ENCODE dbSUPER | 0.4 | -8.8 | -8753 | 0.8 | GLIS2 POU5F1 | APOBEC3F APOBEC3D |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around APOBEC3F on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the APOBEC3F gene promoter:
Regulatory Element Products
Genomic Location for APOBEC3F Gene
- Chromosome:
- 22
- Start:
- 39,040,604 bp from pter
- End:
- 39,055,972 bp from pter
- Size:
- 15,369 bases
- Orientation:
- Plus strand
Genomic View for APOBEC3F Gene
Genes around APOBEC3F on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by Ensembl
- 22q13.1 by Entrez Gene
- 22q13.1 by HGNC
APOBEC3F Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOBEC3F Gene
Proteins for APOBEC3F Gene
-
Protein details for APOBEC3F Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IUX4-ABC3F_HUMAN
- Recommended name:
- DNA dC->dU-editing enzyme APOBEC-3F
- Protein Accession:
- Q8IUX4
- B0QYD4
- Q45F03
- Q6ICH3
- Q7Z2N2
- Q7Z2N5
Protein attributes for APOBEC3F Gene
- Size:
- 373 amino acids
- Molecular mass:
- 45020 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Binds HIV-1 Vif. In the absence of Vif protein, specifically packaged into HIV-1 virions. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with AGO1, AGO2 and AGO3.
- Miscellaneous:
-
- It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.
Three dimensional structures from OCA and Proteopedia for APOBEC3F Gene
Protein Expression for APOBEC3F Gene
Selected DME Specific Peptides for APOBEC3F Gene
- Q8IUX4:
-
- CFLSWFC
- DSKLQEIL
- WLCYEVK
Post-translational modifications for APOBEC3F Gene
Other Protein References for APOBEC3F Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for APOBEC3F
-
Custom Antibody ServicesOriGene Antibodies for APOBEC3F
- Novus Biologicals Antibodies for APOBEC3F
-
Abcam antibodies for APOBEC3F
- Invitrogen Antibodies for APOBEC3F
- antibodies-online Antibodies for APOBEC3F: See all 43
- GeneTex APOBEC3F antibody for APOBEC3F
Protein Products
-
OriGene Purified Proteins for APOBEC3F
- Search Origene for MassSpec and Protein Over-expression Lysates for APOBEC3F
- Origene Custom Protein Services for APOBEC3F
- antibodies-online Proteins for APOBEC3F: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for APOBEC3F
-
Abcam proteins for APOBEC3F
Assay Products
Domains & Families for APOBEC3F Gene
Gene Families for APOBEC3F Gene
Protein Domains for APOBEC3F Gene
Suggested Antigen Peptide Sequences for APOBEC3F Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IUX4UniProtKB/Swiss-Prot:
ABC3F_HUMAN :- The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.
- Belongs to the cytidine and deoxycytidylate deaminase family.
- Domain:
-
- The CMP/dCMP deaminase domain 1 mediates RNA binding, RNA-dependent oligomerization and virion incorporation whereas the CMP/dCMP deaminase domain 2 confers deoxycytidine deaminase activity and substrate sequence specificity.
- Family:
-
- Belongs to the cytidine and deoxycytidylate deaminase family.
Function for APOBEC3F Gene
Molecular function for APOBEC3F Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cytidine + H(2)O = uridine + NH(3).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents its incorporation into progeny virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome.
- UniProtKB/Swiss-Prot Function:
- DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by IFN-alpha.
Enzyme Numbers (IUBMB) for APOBEC3F Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 11863358 |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004126 | cytidine deaminase activity | IDA | 17121840 |
| GO:0005515 | protein binding | IPI | 16699599 |
| GO:0008270 | zinc ion binding | IDA | 11863358 |
Phenotypes for APOBEC3F Gene
- GenomeRNAi human phenotypes for APOBEC3F:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased homologous recombination repair frequency
- Increased cell number in S
- Decreased caspase 3/7 activity
- Decreased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOBEC3F
-
-
ViGene Biosciences lentiviral particle packaged cDNA for APOBEC3F gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOBEC3F gene
- Search ViGene Biosciences for APOBEC3F
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC3F
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC3F
- GenScript: Design CRISPR guide RNA sequences for APOBEC3F
miRNA for APOBEC3F Gene
- miRTarBase miRNAs that target APOBEC3F
-
- hsa-mir-3658 (MIRT459274)
- hsa-mir-499a-5p (MIRT459275)
- hsa-mir-208b-3p (MIRT459276)
- hsa-mir-208a-3p (MIRT459277)
- hsa-mir-4433a-3p (MIRT459278)
- hsa-mir-4459 (MIRT459279)
- hsa-mir-4768-3p (MIRT459280)
- hsa-mir-6500-3p (MIRT459281)
- hsa-mir-3614-5p (MIRT459282)
- hsa-mir-548ao-3p (MIRT459283)
- hsa-mir-3667-5p (MIRT459284)
- hsa-mir-6513-5p (MIRT664146)
- hsa-mir-887-5p (MIRT664147)
- hsa-mir-3913-5p (MIRT664148)
- hsa-mir-3122 (MIRT664149)
- hsa-mir-450a-1-3p (MIRT664150)
- hsa-mir-6780a-5p (MIRT664151)
- hsa-mir-6779-5p (MIRT664152)
- hsa-mir-3689c (MIRT664153)
- hsa-mir-3689b-3p (MIRT664154)
- hsa-mir-3689a-3p (MIRT664155)
- hsa-mir-30b-3p (MIRT664156)
- hsa-mir-1273h-5p (MIRT664157)
- hsa-mir-6788-5p (MIRT664158)
- hsa-mir-30c-2-3p (MIRT664159)
- hsa-mir-30c-1-3p (MIRT664160)
- hsa-mir-7977 (MIRT664161)
- hsa-mir-4726-5p (MIRT664162)
- hsa-mir-4640-5p (MIRT664163)
- hsa-mir-6799-5p (MIRT664164)
- hsa-mir-6883-5p (MIRT664165)
- hsa-mir-6785-5p (MIRT664166)
- hsa-mir-4728-5p (MIRT664167)
- hsa-mir-149-3p (MIRT664168)
- hsa-mir-7106-5p (MIRT664169)
- hsa-mir-24-3p (MIRT664170)
- hsa-mir-4284 (MIRT664171)
- hsa-mir-5693 (MIRT664172)
- hsa-mir-383-3p (MIRT664173)
- hsa-mir-3165 (MIRT695050)
- hsa-mir-6745 (MIRT695051)
- hsa-mir-363-5p (MIRT695052)
- hsa-mir-6089 (MIRT695053)
- hsa-mir-483-5p (MIRT695054)
miRNA Products
- Search ViGene Biosciences for APOBEC3F
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOBEC3F
- Browse OriGene Inhibitory RNA Products For APOBEC3F
-
ViGene Biosciences ready-to-package AAV shRNAs for APOBEC3F gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOBEC3F
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3F
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for APOBEC3F
-
ViGene Biosciences adenoviral particle packaged cDNA for APOBEC3F gene
-
ViGene Biosciences lentiviral particle packaged cDNA for APOBEC3F gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOBEC3F gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOBEC3F Gene
Localization for APOBEC3F Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3F Gene
- Cytoplasm. Cytoplasm, P-body.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | IDA | 16699599 |
| GO:0005737 | cytoplasm | IEA,IDA | 16527742 |
| GO:0030529 | intracellular ribonucleoprotein complex | IDA | 16699599 |
| GO:0030895 | apolipoprotein B mRNA editing enzyme complex | TAS | 17121840 |
Pathways & Interactions for APOBEC3F Gene
No Data Available
Interacting Proteins for APOBEC3F Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002230 | positive regulation of defense response to virus by host | IDA | 17121840 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0009972 | cytidine deamination | IEA | -- |
| GO:0010529 | negative regulation of transposition | IDA | 16527742 |
| GO:0016553 | base conversion or substitution editing | IDA | 17121840 |
No data available for Pathways by source and SIGNOR curated interactions for APOBEC3F Gene
Drugs & Compounds for APOBEC3F Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Ammonia |
|
7664-41-7 |
|
Transcripts for APOBEC3F Gene
mRNA/cDNA for APOBEC3F Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for APOBEC3F Gene
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC3F
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC3F
- GenScript: Design CRISPR guide RNA sequences for APOBEC3F
miRNA Products
- Search ViGene Biosciences for APOBEC3F
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOBEC3F
- Browse OriGene Inhibitory RNA Products For APOBEC3F
-
ViGene Biosciences ready-to-package AAV shRNAs for APOBEC3F gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOBEC3F
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3F
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - |
Expression for APOBEC3F Gene
This gene is overexpressed in Ovary (16.0), Lung (13.2), Blymphocyte (11.2), and NK cells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for APOBEC3F Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of APOBEC3F Gene:
APOBEC3FSOURCE GeneReport for Unigene cluster for APOBEC3F Gene:
Hs.659809mRNA Expression by UniProt/SwissProt for APOBEC3F Gene:
Q8IUX4-ABC3F_HUMAN
Tissue specificity:
Widely expressed. Highly expressed in ovary.
Evidence on tissue expression from TISSUES for APOBEC3F Gene
- Spleen(4.2)
- Pancreas(4)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for APOBEC3F
-
OriGene qPCR primer pairs and template standards for APOBEC3F
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOBEC3F Gene
Orthologs for APOBEC3F Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | APOBEC3F 34 |
|
- Species where no ortholog for APOBEC3F was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for APOBEC3F Gene
Paralogs for APOBEC3F Gene
(11) SIMAP similar genes for APOBEC3F Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for APOBEC3F Gene
Variants for APOBEC3F Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000257527 | -- | 39,035,521(+) | AGAAT(C/T)GCTGG | intron-variant | |
| rs1000336007 | -- | 39,026,238(+) | CCGCT(C/T)CTCCT | intron-variant | |
| rs1000485119 | -- | 39,031,060(+) | ACTCC(A/G)GAGGC | intron-variant | |
| rs1000611010 | -- | 39,036,483(+) | ACAGG(C/G)AGTGG | intron-variant | |
| rs1000861291 | -- | 39,053,489(+) | ATGCA(C/T)CTGTA | nc-transcript-variant, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv22523 | CNV | gain | 19812545 |
| esv2673637 | CNV | deletion | 23128226 |
| esv2676044 | CNV | deletion | 23128226 |
| esv2724242 | CNV | deletion | 23290073 |
| esv2724243 | CNV | deletion | 23290073 |
| esv3647751 | CNV | gain | 21293372 |
| esv3647755 | CNV | loss | 21293372 |
| esv3647756 | CNV | gain | 21293372 |
| esv3647757 | CNV | loss | 21293372 |
| esv3647758 | CNV | loss | 21293372 |
| nsv1139065 | CNV | deletion | 24896259 |
| nsv522083 | CNV | loss | 19592680 |
| nsv834196 | CNV | loss | 17160897 |
| nsv964631 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.35;
70.85% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for APOBEC3F Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3F Gene
Disorders for APOBEC3F Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ipex syndrome |
|
|
| theileriasis |
|
|
| hiv-1 |
|
|
Search APOBEC3F in MalaCards
View complete list of genes associated with diseases
Relevant External Links for APOBEC3F
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- APOBEC3F
No data available for UniProtKB/Swiss-Prot and Genatlas for APOBEC3F Gene
Publications for APOBEC3F Gene
- APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G. (PMID: 17121840) Holmes R.K. … Malim M.H. (J. Biol. Chem. 2007) 2 3 22 64
- Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PMID: 16699599) Wichroski M.J. … Rana T.M. (PLoS Pathog. 2006) 3 4 22 64
- A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins. (PMID: 15152192) Wiegand H.L. … Cullen B.R. (EMBO J. 2004) 3 4 22 64
- An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PMID: 11863358) Jarmuz A. … Navaratnam N. (Genomics 2002) 2 3 4 64
- APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ t cells and macrophages. (PMID: 23097438) Chaipan C. … Pathak V.K. (J. Virol. 2013) 3 4 64
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