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APOBEC3F Gene

protein-coding   GIFtS: 55
GCID: GC22P039436

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like...

  See APOBEC3F-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3F1 2     Apolipoprotein B Editing Enzyme Catalytic Polypeptide-Like 3F2
Apolipoprotein B MRNA-Editing Enzyme Catalytic Polypeptide-Like 3F2 3     Apolipoprotein B MRNA Editing Enzyme Cytidine Deaminase2
A3F2 3     DNA DC->DU-Editing Enzyme APOBEC-3F2
ARP82     Induced Upon T-Cell Activation2
BK150C2.4.MRNA2     EC 3.5.4.-3
KA62     EC 3.5.48

External Ids:    HGNC: 173561   Entrez Gene: 2003162   Ensembl: ENSG000001283947   OMIM: 6089935   UniProtKB: Q8IUX43   

Export aliases for APOBEC3F gene to outside databases

Previous GC identifers: GC22P036031 GC22P036051 GC22P037679 GC22P037761 GC22P022404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOBEC3F Gene:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found
in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins
that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is
thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.
Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq,
Jul 2008)

GeneCards Summary for APOBEC3F Gene:
APOBEC3F (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F) is a protein-coding gene. Diseases associated with APOBEC3F include hiv-1. GO annotations related to this gene include cytidine deaminase activity and RNA binding. An important paralog of this gene is APOBEC3G.

UniProtKB/Swiss-Prot: ABC3F_HUMAN, Q8IUX4
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against
vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the
initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense
single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant
detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works
prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded
RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV),
xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR
retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of
active DNA demethylation

Gene Wiki entry for APOBEC3F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOBEC3F gene promoter:
         Hand1   ZID   E47   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOBEC3F promoter sequence
   Search Chromatin IP Primers for APOBEC3F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOBEC3F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1-q13.2

APOBEC3F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC3F gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039436:  view genomic region     (about GC identifiers)

Start:
39,436,609 bp from pter      End:
39,451,977 bp from pter
Size:
15,369 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ABC3F_HUMAN, Q8IUX4 (See protein sequence)
Recommended Name: DNA dC->dU-editing enzyme APOBEC-3F  
Size: 373 amino acids; 45020 Da
Cofactor: Zinc (By similarity)
Subunit: Binds HIV-1 Vif. In the absence of Vif protein, specifically packaged into HIV-1 virions. Interacts with
APOBEC3G in an RNA-dependent manner. Interacts with AGO1, AGO2 and AGO3
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 22
2 PDB 3D structures from and Proteopedia for APOBEC3F:
4IOU (3D)        4J4J (3D)    
Secondary accessions: B0QYD4 Q45F03 Q6ICH3 Q7Z2N2 Q7Z2N5
Alternative splicing: 3 isoforms:  Q8IUX4-1   Q8IUX4-2   Q8IUX4-3   (May be due to a competing donor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APOBEC3F: NX_Q8IUX4

Explore proteomics data for APOBEC3F at MOPED

3 DME Specific Peptides for APOBEC3F (Q8IUX4)
 CFLSWFC  WLCYEVK  DSKLQEIL 


See APOBEC3F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001006667.1  NP_660341.2  

ENSEMBL proteins: 
 ENSP00000309749   ENSP00000370977  

APOBEC3F Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
APOBEC: Apolipoprotein B mRNA editing enzymes

3 InterPro protein domains:
 IPR016192 APOBEC/CMP_deaminase_Zn-bd
 IPR013158 APOBEC_N
 IPR016193 Cytidine_deaminase-like

Graphical View of Domain Structure for InterPro Entry Q8IUX4

ProtoNet protein and cluster: Q8IUX4

2 Blocks protein domains:
IPB002125 Cytidine/deoxycytidylate deaminase
IPB007904 APOBEC-like


UniProtKB/Swiss-Prot: ABC3F_HUMAN, Q8IUX4
Domain: The CMP/dCMP deaminase zinc-binding 1 domain mediates RNA binding, RNA-dependent oligomerization and
virion incorporation whereas the CMP/dCMP deaminase zinc-binding 2 domain confers deoxycytidine deaminase
activity and substrate sequence specificity (PubMed:17020885)
Similarity: Belongs to the cytidine and deoxycytidylate deaminase family
Similarity: Contains 2 CMP/dCMP deaminase zinc-binding domains


Find genes that share domains with APOBEC3F           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ABC3F_HUMAN, Q8IUX4
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against
vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the
initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense
single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant
detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works
prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded
RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV),
xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR
retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of
active DNA demethylation
Catalytic activity: Cytidine + H(2)O = uridine + NH(3)
Enzyme regulation: Antiviral activity is neutralized by the HIV-1 virion infectivity factor (VIF), that prevents
its incorporation into progeny virions by both inhibiting its translation and/or by inducing its ubiquitination
and subsequent degradation by the 26S proteasome
Induction: Up-regulated by IFN-alpha

     Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003723RNA binding IDA11863358
GO:0003824catalytic activity ----
GO:0004126cytidine deaminase activity IDA17121840
GO:0005515protein binding IPI16699599
GO:0008270zinc ion binding IDA11863358
     
Find genes that share ontologies with APOBEC3F           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for APOBEC3F:
 Decreased viability  Increased cell number in G2M,  

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ABC3F_HUMAN, Q8IUX4: Cytoplasm. Cytoplasm, P-body
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000932cytoplasmic mRNA processing body IDA16699599
GO:0005737cytoplasm IDA16527742
GO:0030529ribonucleoprotein complex IDA16699599
GO:0030895apolipoprotein B mRNA editing enzyme complex TAS17121840

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for APOBEC3F About    
See pathways by source

SuperPathContained pathways About
1HIV Life Cycle
HIV Infection0.62
APOBEC3G mediated resistance to HIV-1 infection0.00
Host Interactions of HIV factors0.60
2CDK-mediated phosphorylation and removal of Cdc6
Vif-mediated degradation of APOBEC3G0.86
3Disease
Disease



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APOBEC3F
Interactions:

    GeneGlobe Interaction Network for APOBEC3F

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for APOBEC3F (Q8IUX43 ENSP000003097494) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
APOBEC3GQ9HC163, ENSP000003850574I2D: score=1 STRING: ENSP00000385057
A1CFENSP000002826414STRING: ENSP00000282641
APOBEC3DENSP000002160994STRING: ENSP00000216099
UBCENSP000003448184STRING: ENSP00000344818
ACDENSP000003774964STRING: ENSP00000377496
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Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002230positive regulation of defense response to virus by host IDA17121840
GO:0009972cytidine deamination IDA17121840
GO:0010529negative regulation of transposition IDA16527742
GO:0016553base conversion or substitution editing IDA17121840
GO:0045071negative regulation of viral genome replication IDA16378963

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for APOBEC3F (ABC3F)

2 Novoseek inferred chemical compound relationships for APOBEC3F gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cytidine 88.8 22 17121840 (3), 16201018 (2), 16731937 (1), 16842218 (1) (see all 14)
cytosine 51 10 15647250 (3), 17038330 (2)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for APOBEC3F gene (2 alternative transcripts): 
NM_001006666.1  NM_145298.5  

Unigene Cluster for APOBEC3F:

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
Hs.659809  [show with all ESTs]
Unigene Representative Sequence: NM_145298
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000491387 ENST00000308521(uc011aog.1 uc003aww.3) ENST00000381565(uc003awv.3)
ENST00000476513
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Additional mRNA sequence: 

AK294810.1 BC038808.1 CR456395.1 JF262037.1 U38435.1 

10 DOTS entries:

DT.86837797  DT.311082  DT.40259870  DT.91640746  DT.91799503  DT.75134435  DT.95214959  DT.100740775 
DT.312711  DT.95174104 

Selected AceView cDNA sequences (see all 142):

BF508948 BX112841 BQ921509 CR456395 BM564332 NM_145298 AI217046 BQ056344 
AW505140 BX332251 BU174800 AI799894 BC038808 BM977965 BG744406 CF142810 
AI092348 BX326730 AI910810 BX331204 BE892372 BG758984 BF437832 BX367450 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC3F (see all 10)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17
SP1:                                                                                -           -                             -                                 
SP2:              -     -     -     -     -     -     -     -     -     -     -     -           -                             -                                 
SP3:                          -     -     -     -     -     -     -     -     -     -           -                             -                                 
SP4:                                -                                                                                                                           
SP5:                                                                                                                                                            


ECgene alternative splicing isoforms for APOBEC3F

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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APOBEC3F expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAGCCCCCCA
APOBEC3F Expression
About this image

APOBEC3F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

APOBEC3F Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.659809

UniProtKB/Swiss-Prot: ABC3F_HUMAN, Q8IUX4
Tissue specificity: Widely expressed. Highly expressed in ovary

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for APOBEC3F gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia APOBEC3F1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like more 98.48(n)
96.78(a)
  470275  XM_525658.3  XP_525658.2 


ENSEMBL Gene Tree for APOBEC3F (if available)
TreeFam Gene Tree for APOBEC3F (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for APOBEC3F gene
APOBEC3G2  APOBEC12  APOBEC22  APOBEC3B2  APOBEC3D2  APOBEC3C2  APOBEC3A2  APOBEC3H2  
AICDA2  
11 SIMAP similar genes for APOBEC3F using alignment to 3 protein entries:     ABC3F_HUMAN (see all proteins):
APOBEC3C    APOBEC3D    APOBEC3DE    bK150C2.9    APOBEC3B    APOBEC3G
AICDA    AID    APOBEC2    APOBEC3A    APOBEC3H

Find genes that share paralogs with APOBEC3F           About GenesLikeMe


1 Pseudogenes.org Pseudogene for APOBEC3F
PGOHUM00000246587


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for APOBEC3F (see all 501)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1886293531,2
--39434749(+) TGCCTC/TCTGGG 2 -- us2k10--------
rs1928283211,2
--39434751(+) CCTTCC/TGGGTT 2 -- us2k10--------
rs1382356631,2
--39434878(+) GGTCTC/TGAACT 2 -- us2k10--------
rs1164190391,2
C,F--39434898(+) CATGCG/CTGTCT 2 -- us2k11Minor allele frequency- C:0.12WA 118
rs57507261,2
C,F,A,H--39434907(+) ctgtaC/Tagaaa 2 -- us2k118Minor allele frequency- T:0.49NS EA WA NA CSA 2054
rs1132611591,2
C,F--39434968(+) TGCAAC/GTGGGC 2 -- us2k10--------
rs1134680171,2
C,F--39435004(+) GGGAGG/ATAAGA 2 -- us2k11Minor allele frequency- A:0.50NA 2
rs1913429781,2
C--39435095(+) GTCACA/CAGGTG 2 -- us2k10--------
rs1495885561,2
C--39435122(+) GAGACC/TCATTG 2 -- us2k10--------
rs1400245851,2
C--39435370(+) TCAGAC/TGATCC 2 -- us2k10--------

HapMap Linkage Disequilibrium report for APOBEC3F (39436609 - 39451977 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for APOBEC3F (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
esv2676044CNV Deletion23128226
esv2724243CNV Deletion23290073
esv2673637CNV Deletion23128226
esv2724242CNV Deletion23290073
nsv522083CNV Loss19592680
nsv834196CNV Loss17160897
nsv915084CNV Loss21882294
nsv915083CNV Loss21882294
nsv915085CNV Gain21882294
nsv915081CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608993    OMIM disorders: --

1 disease for APOBEC3F:    
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hiv-1


Find genes that share disorders with APOBEC3F           About GenesLikeMe

2 Novoseek inferred disease relationships for APOBEC3F gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
retrovirus infections 62.6 1 17078485 (1)
immunodeficiency 57.5 9 18598197 (1), 15479843 (1), 16963778 (1), 16912295 (1) (see all 9)


Export disorders for APOBEC3F gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for APOBEC3F gene, integrated from 10 sources (see all 151):
(articles sorted by number of sources associating them with APOBEC3F)
    Utopia: connect your pdf to the dynamic
world of online information

  1. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PubMed id 11863358)1, 2, 3 Jarmuz A....Navaratnam N. (Genomics 2002)
  2. APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G. (PubMed id 17121840)1, 3, 9 Holmes R.K....Malim M.H. (J. Biol. Chem. 2007)
  3. A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins. (PubMed id 15152192)1, 2, 9 Wiegand H.L.... Cullen B.R. (EMBO J. 2004)
  4. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2, 9 Wichroski M.J.... Rana T.M. (PLoS Pathog. 2006)
  5. APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ t cells and macrophages. (PubMed id 23097438)1, 2 Chaipan C.... Pathak V.K. (J. Virol. 2013)
  6. Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n. (PubMed id 22807680)1, 2 Refsland E.W.... Harris R.S. (PLoS Pathog. 2012)
  7. Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1. (PubMed id 21835787)1, 2 Hultquist J.F.... Harris R.S. (J. Virol. 2011)
  8. APOBEC3F and APOBEC3G inhibit HIV-1 DNA integration by different mechanisms. (PubMed id 20219927)1, 2 Mbisa J.L.... Pathak V.K. (J. Virol. 2010)
  9. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. (PubMed id 18304004)1, 2 Chiu Y.L. and Greene W.C. (Annu. Rev. Immunol. 2008)
  10. APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. (PubMed id 16527742)1, 2 Chen H.... Weitzman M.D. (Curr. Biol. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 200316 HGNC: 17356 AceView: APOBEC3F Ensembl:ENSG00000128394 euGenes: HUgn200316
ECgene: APOBEC3F H-InvDB: APOBEC3F

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for APOBEC3F Pharmacogenomics, SNPs, Pathways
SeattleSNPshttp://pga.gs.washington.edu/data/apobec3f/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for APOBEC3F gene:
Search GeneIP for patents involving APOBEC3F

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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