Aliases for APOBEC3C Gene
Aliases for APOBEC3C Gene
External Ids for APOBEC3C Gene
- HGNC: 17353
- Entrez Gene: 27350
- Ensembl: ENSG00000244509
- OMIM: 607750
- UniProtKB: Q9NRW3
Previous GeneCards Identifiers for APOBEC3C Gene
- GC22U990105
- GC22P036025
- GC22P037653
- GC22P037734
- GC22P039379
- GC22P022378
- GC22P039410
Summaries for APOBEC3C Gene
-
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOBEC3C Gene
APOBEC3C (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3C) is a Protein Coding gene. Among its related pathways are mRNA Editing- C to U Conversion and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines. An important paralog of this gene is APOBEC3F.
UniProtKB/Swiss-Prot for APOBEC3C Gene
-
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3C Gene
Genomics for APOBEC3C Gene
Regulatory Elements for APOBEC3C Gene
Enhancers for APOBEC3C Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around APOBEC3C on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for APOBEC3C Gene
- Chromosome:
- 22
- Start:
- 39,014,083 bp from pter
- End:
- 39,020,352 bp from pter
- Size:
- 6,270 bases
- Orientation:
- Plus strand
Genomic View for APOBEC3C Gene
Genes around APOBEC3C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.1 by Ensembl
- 22q13.1 by Entrez Gene
- 22q13.1 by HGNC
APOBEC3C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOBEC3C Gene
Proteins for APOBEC3C Gene
-
Protein details for APOBEC3C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRW3-ABC3C_HUMAN
- Recommended name:
- DNA dC->dU-editing enzyme APOBEC-3C
- Protein Accession:
- Q9NRW3
- B2R884
- Q5JZ92
- Q7Z2N7
- Q96F12
Protein attributes for APOBEC3C Gene
- Size:
- 190 amino acids
- Molecular mass:
- 22826 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homodimer. Interacts with human foamy virus protein Bet; this interaction does not induce APOBEC3C degradation, but prevents dimerization and incorporation into virion of the latter. Interacts with TRIB3 and AGO2.
- Miscellaneous:
-
- It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.
- SequenceCaution:
-
- Sequence=AAF86650.1; Type=Frameshift; Positions=172; Evidence={ECO:0000305};
Protein Expression for APOBEC3C Gene
Post-translational modifications for APOBEC3C Gene
Other Protein References for APOBEC3C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for APOBEC3C
-
Abcam antibodies for APOBEC3C
- Invitrogen Antibodies for APOBEC3C
- antibodies-online Antibodies for APOBEC3C: See all 54
- GeneTex APOBEC3C antibody for APOBEC3C
Protein Products
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OriGene Purified Proteins for APOBEC3C
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- antibodies-online Proteins for APOBEC3C: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for APOBEC3C
-
Abcam proteins for APOBEC3C
Assay Products
No data available for DME Specific Peptides for APOBEC3C Gene
Domains & Families for APOBEC3C Gene
Gene Families for APOBEC3C Gene
Protein Domains for APOBEC3C Gene
Suggested Antigen Peptide Sequences for APOBEC3C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NRW3- Family:
-
- Belongs to the cytidine and deoxycytidylate deaminase family.
Function for APOBEC3C Gene
Molecular function for APOBEC3C Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cytidine + H(2)O = uridine + NH(3).
- UniProtKB/Swiss-Prot Function:
- DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by IFN-alpha.
Enzyme Numbers (IUBMB) for APOBEC3C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 22915799 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for APOBEC3C Gene
- GenomeRNAi human phenotypes for APOBEC3C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for APOBEC3C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOBEC3C gene
- Search ViGene Biosciences for APOBEC3C
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC3C
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC3C
- GenScript: Design CRISPR guide RNA sequences for APOBEC3C
miRNA for APOBEC3C Gene
- miRTarBase miRNAs that target APOBEC3C
miRNA Products
- Search ViGene Biosciences for APOBEC3C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOBEC3C
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-
ViGene Biosciences ready-to-package AAV shRNAs for APOBEC3C gene
Clone Products
-
OriGene ORF clones in human for APOBEC3C
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- VectorBuilder custom plasmid, inducible vectors for APOBEC3C
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for APOBEC3C
-
ViGene Biosciences adenoviral particle packaged cDNA for APOBEC3C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for APOBEC3C gene
-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOBEC3C Gene
Localization for APOBEC3C Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3C Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 21835787 |
| GO:0005737 | cytoplasm | IDA,IEA | 21835787 |
Pathways & Interactions for APOBEC3C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Editing- C to U Conversion |
.82
|
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for APOBEC3C Gene
4 Reactome pathways for APOBEC3C Gene
Interacting Proteins for APOBEC3C Gene
Selected Interacting proteins:
ENSP00000355340
Q9NRW3-ABC3C_HUMAN
for APOBEC3C Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009972 | cytidine deamination | IDA | 21632763 |
| GO:0010529 | negative regulation of transposition | IDA | 16527742 |
| GO:0016032 | viral process | IEA | -- |
| GO:0045071 | negative regulation of viral genome replication | IDA | 21632763 |
| GO:0045087 | innate immune response | IEA | -- |
No data available for SIGNOR curated interactions for APOBEC3C Gene
Drugs & Compounds for APOBEC3C Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Ammonia |
|
7664-41-7 |
|
Transcripts for APOBEC3C Gene
mRNA/cDNA for APOBEC3C Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for APOBEC3C Gene
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC3C
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC3C
- GenScript: Design CRISPR guide RNA sequences for APOBEC3C
miRNA Products
- Search ViGene Biosciences for APOBEC3C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOBEC3C
- Browse OriGene Inhibitory RNA Products For APOBEC3C
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ViGene Biosciences ready-to-package AAV shRNAs for APOBEC3C gene
Clone Products
-
OriGene ORF clones in human for APOBEC3C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for APOBEC3C
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOBEC3C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for APOBEC3C Gene
mRNA differential expression in normal tissues according to GTEx for APOBEC3C Gene
This gene is overexpressed in Whole Blood (x4.3).
This gene is overexpressed in Tlymphocyte (14.0), Peripheral blood mononuclear cells (9.5), Monocytes (8.8), and NK cells (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APOBEC3C Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of APOBEC3C Gene:
APOBEC3CSOURCE GeneReport for Unigene cluster for APOBEC3C Gene:
Hs.441124mRNA Expression by UniProt/SwissProt for APOBEC3C Gene:
Q9NRW3-ABC3C_HUMAN
Tissue specificity:
Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.
Evidence on tissue expression from TISSUES for APOBEC3C Gene
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for APOBEC3C
-
OriGene qPCR primer pairs and template standards for APOBEC3C
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOBEC3C Gene
Orthologs for APOBEC3C Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | APOBEC3C 34 35 |
|
- Species where no ortholog for APOBEC3C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for APOBEC3C Gene
Paralogs for APOBEC3C Gene
(11) SIMAP similar genes for APOBEC3C Gene using alignment to 3 proteins:
Variants for APOBEC3C Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000330400 | -- | 39,014,557(+) | CACGA(C/G)TGCTG | intron-variant | |
| rs1000641205 | -- | 39,013,973(+) | GGGGC(A/C)CCTGC | upstream-variant-2KB | |
| rs1001663786 | -- | 39,016,800(+) | GAAGG(A/C)AGGCA | intron-variant | |
| rs1001704637 | -- | 39,012,543(+) | GGAAG(A/T)TTATT | upstream-variant-2KB | |
| rs1001946306 | -- | 39,015,329(+) | CTGGG(A/G)GGTTG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1001536 | CNV | loss | 20482838 |
| esv2724241 | CNV | deletion | 23290073 |
| esv2763703 | CNV | loss | 21179565 |
| esv3647751 | CNV | gain | 21293372 |
| esv3647753 | CNV | gain | 21293372 |
| nsv834196 | CNV | loss | 17160897 |
| nsv962793 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.72;
15.19% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for APOBEC3C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- APOBEC3C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3C Gene
Disorders for APOBEC3C Gene
Relevant External Links for APOBEC3C
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- APOBEC3C
No disorders were found for APOBEC3C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC3C Gene
Publications for APOBEC3C Gene
- An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PMID: 11863358) Jarmuz A. … Navaratnam N. (Genomics 2002) 2 3 4 64
- Retroelements versus APOBEC3 family members: No great escape from the magnificent seven. (PMID: 22912627) Arias J.F. … Tokunaga K. (Front. Microbiol. 2012) 3 4 64
- HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. (PMID: 22915799) Phalora P.K. … Malim M.H. (J. Virol. 2012) 3 4 64
- Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. (PMID: 21496894) Guo J.U. … Song H. (Cell 2011) 3 4 64
- Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1. (PMID: 21835787) Hultquist J.F. … Harris R.S. (J. Virol. 2011) 3 4 64
Products for APOBEC3C Gene
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- GeneTex APOBEC3C antibody for APOBEC3C
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- ViGene Biosciences adenoviral particle packaged cDNA for APOBEC3C gene
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- Search ViGene Biosciences for APOBEC3C
- Horizon Cell Lines for APOBEC3C
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOBEC3C
- VectorBuilder custom plasmid, inducible vectors for APOBEC3C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for APOBEC3C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
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