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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOBEC3B Gene

protein-coding   GIFtS: 56
GCID: GC22P039378

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3B1 2     bK150C2.22
Phorbolin 31 2     Cytidine Deaminase2
Phorbolin-1-Related Protein2 3     DNA DC->DU-Editing Enzyme APOBEC-3B2
A3B2 3     Phorbolin 22
PHRBNL2 5     phorbolin-2/32
APOBEC1L2     Probable DNA DC->DU-Editing Enzyme APOBEC-3B2
ARCD32     EC 3.5.4.-3
ARP42     Phorbolin-2/33
DJ742C19.22     EC 3.5.48

External Ids:    HGNC: 173521   Entrez Gene: 95822   Ensembl: ENSG000001797507   OMIM: 6071105   UniProtKB: Q9UH173   

Export aliases for APOBEC3B gene to outside databases

Previous GC identifers: GC22P035992 GC22P037621 GC22P037702 GC22P022346


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOBEC3B Gene:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found
in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins
that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is
thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid
gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent
gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to
have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for APOBEC3B Gene: 
APOBEC3B (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B) is a protein-coding gene. Diseases associated with APOBEC3B include hepatitis b virus infection, and hiv type 1. GO annotations related to this gene include RNA binding and deoxycytidine deaminase activity. An important paralog of this gene is APOBEC3G.

UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral
nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the
conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in
the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along
with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient
antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate
double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency
virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility
of LTR and non-LTR retrotransposons

Gene Wiki entry for APOBEC3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOBEC3B gene promoter:
         Max1   USF1   MAZR   SREBP-1c   LCR-F1   SREBP-1b   Evi-1   Arnt   SREBP-1a   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOBEC3B promoter sequence
   Search SABiosciences Chromatin IP Primers for APOBEC3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1-q13.2   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1-q13.2

APOBEC3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC3B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039378:  view genomic region     (about GC identifiers)

Start:
39,378,352 bp from pter      End:
39,388,809 bp from pter
Size:
10,458 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17 (See protein sequence)
Recommended Name: DNA dC->dU-editing enzyme APOBEC-3B  
Size: 382 amino acids; 45924 Da
Cofactor: Zinc
Subunit: Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1
Subcellular location: Nucleus
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 22
Sequence caution: Sequence=AAD00089.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD00090.1; Type=Frameshift; Positions=59, 134; Note=Frameshifts result in two separate ORFs termed
phorbolins 2 and 3;
Secondary accessions: B0QYD2 O95618 Q20WL1 Q5IFJ4 Q7Z2N3 Q7Z6D6 Q9UE74
Alternative splicing: 3 isoforms:  Q9UH17-1   Q9UH17-2   Q9UH17-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APOBEC3B: NX_Q9UH17

Explore proteomics data for APOBEC3B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UH17

  • 4 DME Specific Peptides for APOBEC3B (Q9UH17)
     CFLSWFC  WLCYEVK  PFQPWDGL  EHSQALSGRL 

    APOBEC3B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APOBEC3B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001257340.1  NP_004891.4  

    ENSEMBL proteins: 
     ENSP00000385068   ENSP00000385060   ENSP00000338897   ENSP00000327459  

    Human Recombinant Protein Products for APOBEC3B: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for APOBEC3B 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16699599

    APOBEC3B for ontologies           About GeneDecksing



    APOBEC3B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    APOBEC: Apolipoprotein B mRNA editing enzymes

    4 InterPro protein domains:
     IPR016193 Cytidine_deaminase-like
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR007904 APOBEC_C
     IPR013158 APOBEC_N

    Graphical View of Domain Structure for InterPro Entry Q9UH17

    ProtoNet protein and cluster: Q9UH17

    2 Blocks protein domains:
    IPB002125 Cytidine/deoxycytidylate deaminase
    IPB007904 APOBEC-like


    UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
    Domain: The CMP/dCMP deaminase zinc-binding 1 domain mediates RNA binding, RNA-dependent oligomerization and
    virion incorporation whereas the CMP/dCMP deaminase zinc-binding 2 domain confers deoxycytidine deaminase
    activity and substrate sequence specificity (PubMed:17020885)
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family
    Similarity: Contains 2 CMP/dCMP deaminase zinc-binding domains


    APOBEC3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABC3B_HUMAN, Q9UH17
    Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
    retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral
    nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the
    conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in
    the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along
    with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient
    antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate
    double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency
    virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility
    of LTR and non-LTR retrotransposons
    Catalytic activity: Cytidine + H(2)O = uridine + NH(3)
    Induction: Phorbol 12-myristate 13-acetate (PMA) induces overexpression in keratinocytes. Up-regulated by
    IFN-alpha

         Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0008270zinc ion binding IEA--
    GO:0016814hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines ----
    GO:0047844deoxycytidine deaminase activity IMP--
         
    APOBEC3B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for APOBEC3B:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Apobec3):
     immune system  mortality/aging  normal  tumorigenesis 

    APOBEC3B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Apobec3tm1Msn for APOBEC3B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for APOBEC3B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APOBEC3B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOBEC3B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOBEC3B 

    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOBEC3B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for APOBEC3B (Q9UH173 ENSP000003274594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3CQ9BXW43, ENSP000003497854I2D: score=1 STRING: ENSP00000349785
    GABARAPL1Q9H0R83I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010529negative regulation of transposition IDA16527742
    GO:0045087innate immune response IEA--
    GO:0051607defense response to virus IDA--

    APOBEC3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOBEC3B (ABC3B)

    Search CenterWatch for drugs/clinical trials and news about APOBEC3B / ABC3B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APOBEC3B gene (2 alternative transcripts): 
    NM_001270411.1  NM_004900.4  

    Unigene Cluster for APOBEC3B:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
    Hs.226307  [show with all ESTs]
    Unigene Representative Sequence: NM_004900
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407298 ENST00000402182(uc003awo.1 uc003awp.1 uc003awq.1)
    ENST00000335760 ENST00000333467
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOBEC3B
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: APOBEC3B (NM_004900)
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    Additional mRNA sequence: 

    AY743217.1 BC031803.1 BC053859.1 BC126416.1 BC144146.1 CR456393.1 CT841510.1 U03891.2 
    U61083.1 

    7 DOTS entries:

    DT.456333  DT.95286451  DT.100726424  DT.100001051  DT.86840491  DT.95155351  DT.95087702 

    24/55 AceView cDNA sequences (see all 55):

    NM_004900 BI029063 CR456393 BI029065 BE644606 BX114955 BU584024 C00488 
    U03891 AI281048 AW368715 NM_145699 T71211 BU727763 BG576770 AI761325 
    BV197494 BU584431 H79385 CB218515 BI030278 BM788028 BM687484 AA603662 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOBEC3B expression in normal human tissues (normalized intensities)      APOBEC3B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    APOBEC3B Expression
    About this image


    APOBEC3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Mesenchymal Stem Cells
             Umbilical cord blood-derived mesenchymal stem cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Human Intestinal Smooth Muscle Cells (HISMC)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived mesenchymal stem cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
             Human Preadipocyte-subcutaneous (HPA-s)   
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5

    See APOBEC3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOBEC3B

    SOURCE GeneReport for Unigene cluster: Hs.226307

    UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
    Tissue specificity: Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart,
    thymus, prostate and ovary. Also expressed at low levels in several other tissues

        SABiosciences Custom PCR Arrays for APOBEC3B
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for APOBEC3B gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apobec31 , 5 apolipoprotein B mRNA editing enzyme, catalytic polypeptide more1, 5 56.84(n)1
    39.02(a)1
      15 (37.85 cM)5
    802871  NM_001160415.11  NP_001153887.11 
     798916595 


    ENSEMBL Gene Tree for APOBEC3B (if available)
    TreeFam Gene Tree for APOBEC3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOBEC3B gene
    APOBEC3G2  APOBEC3F2  APOBEC12  APOBEC22  APOBEC3D2  APOBEC3C2  APOBEC3A2  APOBEC3H2  
    AICDA2  
    10 SIMAP similar genes for APOBEC3B using alignment to 2 protein entries:     ABC3B_HUMAN (see all proteins):
    APOBEC3A    bK150C2.9    APOBEC3F    APOBEC3G    APOBEC3D    APOBEC3DE
    APOBEC3C    AICDA    AID    APOBEC2

    APOBEC3B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for APOBEC3B
    PGOHUM00000246585


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/25 SNPs in APOBEC3B are shown (see all 25)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0334554
    ----see VAR_0334552 S A mis40--------
    VAR_0181444
    ----see VAR_0181442 T K mis40--------
    VAR_0487224
    ----see VAR_0487222 R H mis40--------
    VAR_0181434
    ----see VAR_0181432 P L mis40--------
    VAR_0181424
    ----see VAR_0181422 K E mis40--------
    rs121592731,2
    A--39384686(+) tctctC/Ttctct 2 -- int1 trp30--------
    rs581104351,2
    C,F--39384687(+) TCTCT-/CT/CTTTCTCTC
    TTTCTTTCT
    /TC/TT
    TTCTT
    4 -- int1 cds12NA CSA 4
    rs170005921,2
    C,F,H--39388815(+) TGTAGC/TGGACC 2 -- int16Minor allele frequency- T:0.03NA NS EA 402
    rs1501646851,2
    C--39388833(+) GGGAAA/GGGTCA 2 -- int10--------
    rs1875066391,2
    C--39388922(+) ACAGAA/GCCCCG 2 -- int10--------

    HapMap Linkage Disequilibrium report for APOBEC3B (39378352 - 39388809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for APOBEC3B (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724238CNV Deletion23290073
    dgv833e199CNV Deletion23128226
    esv2495318CNV Deletion19546169
    esv2604392CNV Loss19546169
    nsv438346CNV Loss16468122
    dgv36n47CNV Loss21111241
    nsv915080CNV Loss21882294
    nsv198CNV Loss15895083
    esv29947CNV Loss18421352
    nsv9907CNV Loss18304495


    Human Gene Mutation Database (HGMD): APOBEC3B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing APOBEC3B
    DNA2.0 Custom Variant and Variant Library Synthesis for APOBEC3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607110    OMIM disorders: --

    11 diseases for APOBEC3B:    About MalaCards
    hepatitis b virus infection    hiv type 1    hepatitis b    albinism
    human t-cell leukemia virus type 1    psoriasis    malaria    hepatitis
    t-cell leukemia    prostatitis    leukemia


    APOBEC3B for disorders           About GeneDecksing

    Genetic Association Database (GAD): APOBEC3B
    Human Genome Epidemiology (HuGE) Navigator: APOBEC3B (4 documents)

    Export disorders for APOBEC3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOBEC3B gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with APOBEC3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1. (PubMed id 10469298)1, 2, 3, 9 Madsen P.P.... Celis J.E. (1999)
    2. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PubMed id 11863358)1, 2, 3 Jarmuz A....Navaratnam N. (2002)
    3. APOBEC3B deletion and risk of HIV-1 acquisition. (PubMed id 19698078)1, 4, 9 An P....Winkler C.A. (2009)
    4. Population stratification of a common APOBEC gene deletion polymorphism. (PubMed id 17447845)1, 4, 9 Kidd J.M....Eichler E.E. (2007)
    5. APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1. (PubMed id 22457529)1, 2 Ooms M....Munk C. (2012)
    6. No evidence of an association between the APOBEC3B de letion polymorphism and susceptibility to HIV infection and AIDS in Japanese an d Indian populations. (PubMed id 20684727)1, 4 Itaya S....Kimura A. (2010)
    7. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. (PubMed id 18304004)1, 2 Chiu Y.L. and Greene W.C. (2008)
    8. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2 Wichroski M.J....Rana T.M. (2006)
    9. Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains. (PubMed id 17020885)1, 2 Hakata Y. and Landau N.R. (2006)
    10. APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. (PubMed id 16527742)1, 2 Chen H....Weitzman M.D. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9582 HGNC: 17352 AceView: APOBEC3BandAPOBEC3A Ensembl:ENSG00000179750 euGenes: HUgn9582
    ECgene: APOBEC3B H-InvDB: APOBEC3B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOBEC3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APOBEC3B gene:
    Search GeneIP for patents involving APOBEC3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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