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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOBEC3B Gene

protein-coding   GIFtS: 53
GCID: GC22P039378

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like...
 Explore 8 diseases affiliated with
APOBEC3B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for APOBEC3B    

Aliases
for APOBEC3B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3B1 2     Cytidine Deaminase2
PHRBNL1 2 5     Phorbolin 22
Phorbolin-1-Related Protein2 3     Phorbolin 32
FLJ212011     Phorbolin-2/33
APOBEC1L2     Probable DNA DC->DU-Editing Enzyme APOBEC-3B2
ARCD32     A3B3
ARP42     EC 3.5.4.-3
DJ742C19.22     Phorbolin-2/33
BK150C2.21     EC 3.5.48

External Ids:    HGNC: 173521   Entrez Gene: 95822   Ensembl: ENSG000001797507   OMIM: 6071105   UniProtKB: Q9UH173   

Export aliases for APOBEC3B gene to outside databases

Previous GC identifers: GC22P035992 GC22P037621 GC22P037702 GC22P022346


Summaries
for APOBEC3B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for APOBEC3B:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a
cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are
structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the
proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the
deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The
breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and
coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon
mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into
target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to
uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand
viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent
mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected
target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or
double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV)
and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons

Gene Wiki entry for APOBEC3B


Genomic Views
for APOBEC3B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOBEC3B gene promoter:
         Max1   USF1   MAZR   SREBP-1c   LCR-F1   SREBP-1b   Evi-1   Arnt   SREBP-1a   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOBEC3B promoter sequence
   Search SABiosciences Chromatin IP Primers for APOBEC3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1-q13.2   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1-q13.2

APOBEC3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC3B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039378:  view genomic region     (about GC identifiers)

Start:
 39,378,352 bp from pter      End:
 39,388,809 bp from pter
Size:
 10,458 bases      Orientation:
 plus strand

Proteins
for APOBEC3B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17 (See protein sequence)
Recommended Name: DNA dC->dU-editing enzyme APOBEC-3B  
Size: 382 amino acids; 45924 Da
Cofactor: Zinc
Subunit: Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1
Subcellular location: Nucleus
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 22
Sequence caution: Sequence=AAD00089.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD00090.1; Type=Frameshift; Positions=59, 134; Note=Frameshifts result in two separate ORFs termed
phorbolins 2 and 3;
Secondary accessions: B0QYD2 O95618 Q20WL1 Q5IFJ4 Q7Z2N3 Q7Z6D6 Q9UE74
Alternative splicing: 3 isoforms:  Q9UH17-1   Q9UH17-2   Q9UH17-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APOBEC3B: NX_Q9UH17

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UH17

    • 4 DME Specific Peptides for APOBEC3B (Q9UH17)
     CFLSWFC  WLCYEVK  PFQPWDGL  EHSQALSGRL 

    APOBEC3B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257340.1  NP_004891.4  

    ENSEMBL proteins: 
     ENSP00000385068   ENSP00000385060   ENSP00000338897   ENSP00000327459  

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    Novus Biologicals APOBEC3B Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for APOBEC3B

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--


    APOBEC3B for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for APOBEC3B

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    Uscn ELISAs and CLIAs for APOBEC3B

    Protein Domains /
    Families
    for APOBEC3B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    APOBEC3B for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR016193 Cytidine_deaminase-like
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR007904 APOBEC_C
     IPR013158 APOBEC_N

    Graphical View of Domain Structure for InterPro Entry Q9UH17

    ProtoNet protein and cluster: Q9UH17

    2 Blocks protein families:
    IPB002125 Cytidine/deoxycytidylate deaminase
    IPB007904 APOBEC-like


    UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
    Domain: The CMP/dCMP deaminase zinc-binding 1 domain mediates RNA binding, RNA-dependent oligomerization and virion
    incorporation whereas the CMP/dCMP deaminase zinc-binding 2 domain confers deoxycytidine deaminase activity and
    substrate sequence specificity (PubMed:17020885)
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family
    Similarity: Contains 2 CMP/dCMP deaminase zinc-binding domains


    Function
    for APOBEC3B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
    Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon
    mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into
    target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to
    uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand
    viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent
    mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected
    target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or
    double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV)
    and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons
    Catalytic activity: Cytidine + H(2)O = uridine + NH(3)
    Induction: Phorbol 12-myristate 13-acetate (PMA) induces overexpression in keratinocytes. Up-regulated by IFN-alpha

    Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0016814hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines ----
    GO:0047844deoxycytidine deaminase activity IMP--


    APOBEC3B for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for APOBEC3B:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Apobec3tm1Msn for APOBEC3B
         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Apobec3):
     immune system  mortality/aging  normal  tumorigenesis 

    APOBEC3B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for APOBEC3B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOBEC3B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for APOBEC3B (Q9UH173 ENSP000003274594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3CQ9BXW43, ENSP000003497854I2D: score=1 STRING: ENSP00000349785
    GABARAPL1Q9H0R83I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010529negative regulation of transposition IDA--
    GO:0051607defense response to virus IDA--


    APOBEC3B for ontologies           About GeneDecksing



    Drugs & Compounds
    for APOBEC3B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOBEC3B
    Search CenterWatch for drugs/clinical trials and news about APOBEC3B / ABC3B 

    Transcripts
    for APOBEC3B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APOBEC3B gene (2 alternative transcripts): 
    NM_001270411.1  NM_004900.4  

    Unigene Cluster for APOBEC3B:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
    Hs.226307  [show with all ESTs]
    Unigene Representative Sequence: NM_004900
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407298 ENST00000402182(uc003awo.1 uc003awp.1 uc003awq.1)
    ENST00000335760 ENST00000333467

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    Inhib. RNA
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    OriGene shRNA RFP: APOBEC3B
    OriGene siRNA: APOBEC3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOBEC3B
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOBEC3B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOBEC3B

    Additional cDNA sequence: 

    AY743217.1 BC031803.1 BC053859.1 BC126416.1 BC144146.1 CR456393.1 CT841510.1 U03891.2 
    U61083.1 

    7 DOTS entries:

    DT.456333  DT.95286451  DT.100726424  DT.100001051  DT.86840491  DT.95155351  DT.95087702 

    24/55 AceView cDNA sequences (see all 55):

    BU584024 BE644606 BI029065 BX114955 NM_004900 CR456393 BI029063 C00488 
    AW368715 BU727763 AK024854 U03891 BU584431 T71211 AA603662 BM463931 
    BU178985 CB218515 BC031803 BI030278 AI761325 AI222763 AI281048 NM_145699 

    GeneLoc Exon Structure


    Expression
    for APOBEC3B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOBEC3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    APOBEC3B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See APOBEC3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOBEC3B

    SOURCE GeneReport for Unigene cluster: Hs.226307

    UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
    Tissue specificity: Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart,
    thymus, prostate and ovary. Also expressed at low levels in several other tissues

        SABiosciences Custom PCR Arrays for APOBEC3B
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC3B

    Orthologs
    for APOBEC3B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for APOBEC3B gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia APOBEC16
    		 --
    		 25(a)
    		 possible ortholog
    		 3(98130519-98131040)


    ENSEMBL Gene Tree for APOBEC3B (if available)
    TreeFam Gene Tree for APOBEC3B (if available) 

    Paralogs
    for APOBEC3B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOBEC3B gene
    APOBEC3G2  APOBEC3D2  APOBEC3F2  APOBEC12  APOBEC22  APOBEC3C2  APOBEC3A2  AICDA2  
    APOBEC3H2  
    10 SIMAP similar genes for APOBEC3B using alignment to 2 protein entries:     ABC3B_HUMAN (see all proteins):
    APOBEC3A    bK150C2.9    APOBEC3F    APOBEC3G    APOBEC3C    APOBEC3D
    APOBEC3DE    AICDA    AID    APOBEC2

    APOBEC3B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for APOBEC3B
    PGOHUM00000246585


    Genomic Variants
    for APOBEC3B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/361 NCBI SNPs in APOBEC3B are shown (see all 361)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs785054901,2
    		C,F,--22344993(+) GCGGTG/AATGAT 1 -- int11Minor allele frequency- A:0.05WA 118
    rs1132554561,2
    		C,F,--22345124(+) AAGTTG/TCCCAG 1 -- int13Minor allele frequency- T:0.04WA CSA 122
    rs1124991261,2
    		--22345591(+) GTAAGG/AAGCGC 1 -- int12Minor allele frequency- A:0.04CSA WA 120
    rs81424621,2
    		C,F,A,H,--22345909(+) AGGGGC/TGCTGC 1 -- int19Minor allele frequency- T:0.19NS CSA WA NA 1358
    rs60013521,2
    		C--22346217(+) GGTGTC/TGCAGA 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1113273941,2
    		--22346357(+) CTGTGC/TGGAGT 1 -- int12Minor allele frequency- T:0.02CSA WA 120
    rs22674001,2
    		C,--22346543(+) CCTCCC/TAGGCT 1 -- int10--------
    rs1139033771,2
    		--22346679(+) GAGCCT/AGAGCC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs788711471,2
    		C,F,--22346750(+) GGAGGG/AGCCAT 1 -- int11Minor allele frequency- A:0.04WA 118
    rs60013531,2
    		C,F,H,--22347079(+) CCCCAC/TTGCTG 1 -- int14Minor allele frequency- T:0.01NS CSA 506

    HapMap Linkage Disequilibrium report for APOBEC3B (39378352 - 39388809 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for APOBEC3B
         11 CNVs: 32467 103175 67891 2026 32468 37519 0549 38981 36029 7349 36030
    Human Gene Mutation Database (HGMD): APOBEC3B

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    Disorders / Diseases
    for APOBEC3B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APOBEC3B for disorders           About GeneDecksing

    OMIM gene information: 607110    OMIM disorders: --

    8 diseases for APOBEC3B:    About MalaCards
    albinism    hepatitis b    psoriasis    hepatitis
    immunodeficiency    prostatitis    hepatitis b virus infection    hiv type 1

    Human Genome Epidemiology (HuGE) Navigator: APOBEC3B (4 documents)

    Export disorders for APOBEC3B gene to outside databases

    Publications
    for APOBEC3B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOBEC3B gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with APOBEC3B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1. (PubMed id 10469298)1, 2, 3, 9 Madsen P.P.... Celis J.E. (1999)
    2. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PubMed id 11863358)1, 2, 3 Jarmuz A....Navaratnam N. (2002)
    3. APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1. (PubMed id 22457529)1, 2 Ooms M....Munk C. (2012)
    4. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. (PubMed id 18304004)1, 2 Chiu Y.L. and Greene W.C. (2008)
    5. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2 Wichroski M.J....Rana T.M. (2006)
    6. Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains. (PubMed id 17020885)1, 2 Hakata Y. and Landau N.R. (2006)
    7. APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. (PubMed id 16527742)1, 2 Chen H....Weitzman M.D. (2006)
    8. Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G. (PubMed id 16060832)1, 2 Rose K.M.... Kabat D. (2005)
    9. APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication. (PubMed id 15466872)1, 2 Yu Q....Landau N.R. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for APOBEC3B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing APOBEC3B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9582 HGNC: 17352 AceView: APOBEC3BandAPOBEC3A Ensembl:ENSG00000179750 euGenes: HUgn9582
    ECgene: APOBEC3B H-InvDB: APOBEC3B

    Other Databases showing APOBEC3B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing APOBEC3B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOBEC3B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for APOBEC3B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for APOBEC3B gene:
    Search GeneIP for patents involving APOBEC3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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