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APOBEC3B Gene

protein-coding   GIFtS: 56
GCID: GC22P039378

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like...

  See APOBEC3B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3B1 2     bK150C2.22
Phorbolin 31 2     Cytidine Deaminase2
Phorbolin-1-Related Protein2 3     DNA DC->DU-Editing Enzyme APOBEC-3B2
A3B2 3     Phorbolin 22
PHRBNL2 5     phorbolin-2/32
APOBEC1L2     Probable DNA DC->DU-Editing Enzyme APOBEC-3B2
ARCD32     EC 3.5.4.-3
ARP42     Phorbolin-2/33
DJ742C19.22     EC 3.5.48
Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide-Like 3B2     

External Ids:    HGNC: 173521   Entrez Gene: 95822   Ensembl: ENSG000001797507   OMIM: 6071105   UniProtKB: Q9UH173   

Export aliases for APOBEC3B gene to outside databases

Previous GC identifers: GC22P035992 GC22P037621 GC22P037702 GC22P022346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOBEC3B Gene:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found
in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins
that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is
thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid
gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent
gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to
have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for APOBEC3B Gene:
APOBEC3B (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B) is a protein-coding gene. Diseases associated with APOBEC3B include human t-cell leukemia virus type 1, and hepatitis b virus infection. GO annotations related to this gene include RNA binding and deoxycytidine deaminase activity. An important paralog of this gene is APOBEC3G.

UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral
nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the
conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in
the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along
with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient
antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate
double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency
virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility
of LTR and non-LTR retrotransposons

Gene Wiki entry for APOBEC3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOBEC3B gene promoter:
         Max1   USF1   MAZR   SREBP-1c   LCR-F1   SREBP-1b   Evi-1   Arnt   SREBP-1a   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOBEC3B promoter sequence
   Search Chromatin IP Primers for APOBEC3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOBEC3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1-q13.2   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1-q13.2

APOBEC3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC3B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039378:  view genomic region     (about GC identifiers)

Start:
39,378,352 bp from pter      End:
39,388,809 bp from pter
Size:
10,458 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17 (See protein sequence)
Recommended Name: DNA dC->dU-editing enzyme APOBEC-3B  
Size: 382 amino acids; 45924 Da
Cofactor: Zinc
Subunit: Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1
Miscellaneous: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene
duplication, on chromosome 22
Sequence caution: Sequence=AAD00089.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD00090.1; Type=Frameshift; Positions=59, 134; Note=Frameshifts result in two separate ORFs termed
phorbolins 2 and 3;
Secondary accessions: B0QYD2 O95618 Q20WL1 Q5IFJ4 Q7Z2N3 Q7Z6D6 Q9UE74
Alternative splicing: 3 isoforms:  Q9UH17-1   Q9UH17-2   Q9UH17-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APOBEC3B: NX_Q9UH17

Explore proteomics data for APOBEC3B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for APOBEC3B (Q9UH17)
     CFLSWFC  WLCYEVK  PFQPWDGL  EHSQALSGRL 


    See APOBEC3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257340.1  NP_004891.4  

    ENSEMBL proteins: 
     ENSP00000385068   ENSP00000385060   ENSP00000338897   ENSP00000327459  

    APOBEC3B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for APOBEC3B

     
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    antibodies-online proteins for APOBEC3B (22 products) 

     
    antibodies-online peptides for APOBEC3B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    APOBEC: Apolipoprotein B mRNA editing enzymes

    4 InterPro protein domains:
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR007904 APOBEC_C
     IPR013158 APOBEC_N
     IPR016193 Cytidine_deaminase-like

    Graphical View of Domain Structure for InterPro Entry Q9UH17

    ProtoNet protein and cluster: Q9UH17

    2 Blocks protein domains:
    IPB002125 Cytidine/deoxycytidylate deaminase
    IPB007904 APOBEC-like


    UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
    Domain: The CMP/dCMP deaminase zinc-binding 1 domain mediates RNA binding, RNA-dependent oligomerization and
    virion incorporation whereas the CMP/dCMP deaminase zinc-binding 2 domain confers deoxycytidine deaminase
    activity and substrate sequence specificity (PubMed:17020885)
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family
    Similarity: Contains 2 CMP/dCMP deaminase zinc-binding domains


    Find genes that share domains with APOBEC3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABC3B_HUMAN, Q9UH17
    Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and
    retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral
    nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the
    conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in
    the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along
    with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient
    antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate
    double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency
    virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility
    of LTR and non-LTR retrotransposons
    Catalytic activity: Cytidine + H(2)O = uridine + NH(3)
    Induction: Phorbol 12-myristate 13-acetate (PMA) induces overexpression in keratinocytes. Up-regulated by
    IFN-alpha

         Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003824catalytic activity ----
    GO:0008270zinc ion binding IEA--
    GO:0016814hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with APOBEC3B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for APOBEC3B:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Apobec3):
     hematopoietic system  immune system  mortality/aging  normal  tumorigenesis 

    Find genes that share phenotypes with APOBEC3B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Apobec3tm1Msn for APOBEC3B

       genOway: Develop your customized and physiologically relevant rodent model for APOBEC3B

    miRNA
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    miRTarBase miRNAs that target APOBEC3B:
    hsa-mir-193b-3p (MIRT016537)

    Block miRNA regulation of human, mouse, rat APOBEC3B using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ABC3B_HUMAN, Q9UH17: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16699599

    Find genes that share ontologies with APOBEC3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APOBEC3B
    Interactions:

        Search GeneGlobe Interaction Network for APOBEC3B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for APOBEC3B (Q9UH173 ENSP000003274594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3CQ9BXW43, ENSP000003497854I2D: score=1 STRING: ENSP00000349785
    GABARAPL1Q9H0R83I2D: score=1 
    MAP1LC3AQ9H4923I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process IMP--
    GO:0010529negative regulation of transposition IDA16527742
    GO:0045087innate immune response IEA--
    GO:0051607defense response to virus IDA--

    Find genes that share ontologies with APOBEC3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOBEC3B (ABC3B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APOBEC3B gene (2 alternative transcripts): 
    NM_001270411.1  NM_004900.4  

    Unigene Cluster for APOBEC3B:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
    Hs.226307  [show with all ESTs]
    Unigene Representative Sequence: NM_004900
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407298 ENST00000402182(uc003awo.1 uc003awp.1 uc003awq.1)
    ENST00000335760 ENST00000333467
    miRNA
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    Additional mRNA sequence: 

    AY743217.1 BC031803.1 BC053859.1 BC126416.1 BC144146.1 CR456393.1 CT841510.1 U03891.2 
    U61083.1 

    7 DOTS entries:

    DT.456333  DT.95286451  DT.100726424  DT.100001051  DT.86840491  DT.95155351  DT.95087702 

    Selected AceView cDNA sequences (see all 55):

    BI029065 C00488 CR456393 NM_004900 BI029063 BX114955 BU584024 BE644606 
    BU584431 BU727763 BU178985 BM463931 BM788028 BU584432 AK024854 BV197494 
    BF514663 BC031803 BI030278 AI222763 T71211 AA603662 CB218515 AI281048 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOBEC3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    APOBEC3B Expression
    About this image


    APOBEC3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Thymus (Hematopoietic System)
             Thymus
    APOBEC3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOBEC3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.226307

    UniProtKB/Swiss-Prot: ABC3B_HUMAN, Q9UH17
    Tissue specificity: Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart,
    thymus, prostate and ovary. Also expressed at low levels in several other tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for APOBEC3B gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apobec31 , 5 apolipoprotein B mRNA editing enzyme, catalytic polypeptide more1, 5 56.82(n)1
    39.2(a)1
      15 (37.85 cM)5
    802871  NM_001160415.11  NP_001153887.11 
     798916595 


    ENSEMBL Gene Tree for APOBEC3B (if available)
    TreeFam Gene Tree for APOBEC3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APOBEC3B gene
    APOBEC3G2  APOBEC3F2  APOBEC12  APOBEC22  APOBEC3D2  APOBEC3C2  APOBEC3A2  APOBEC3H2  
    AICDA2  
    10 SIMAP similar genes for APOBEC3B using alignment to 3 protein entries:     ABC3B_HUMAN (see all proteins):
    APOBEC3A    bK150C2.9    APOBEC3F    APOBEC3G    APOBEC3D    APOBEC3DE
    APOBEC3C    AICDA    AID    APOBEC2

    Find genes that share paralogs with APOBEC3B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for APOBEC3B
    PGOHUM00000246585


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APOBEC3B (see all 25)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs121592731,2
    A--39384686(+) tctctC/Ttctct 2 -- int1 trp30--------
    rs581104351,2
    C,F--39384687(+) TCTCT-/CT/CTTTCTCTC
    TTTCTTTCT
    /TC/TT
    TTCTT
    4 -- int1 cds12NA CSA 4
    rs170005921,2
    C,F,H--39388815(+) TGTAGC/TGGACC 2 -- int16Minor allele frequency- T:0.03NA NS EA 402
    rs1501646851,2
    C--39388833(+) GGGAAA/GGGTCA 2 -- int10--------
    rs1875066391,2
    C--39388922(+) ACAGAA/GCCCCG 2 -- int10--------
    rs1918443291,2
    --39388930(+) CCGCCC/TACCCT 2 -- int10--------
    rs20102641,2
    C,F,A,H--39388993(+) GACAGC/TCAGCA 2 -- int12Minor allele frequency- T:0.25NA 4
    rs20102681,2
    C,F--39389028(+) CCACAC/AACGTG 2 -- int13Minor allele frequency- A:0.17NA 6
    rs284108551,2
    C,F--39389061(+) GCCCTG/CTGTCC 2 -- int11Minor allele frequency- C:0.50NA 2
    rs1824185931,2
    --39389240(+) AGAGGG/TGAGGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for APOBEC3B (39378352 - 39388809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for APOBEC3B (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724238CNV Deletion23290073
    dgv833e199CNV Deletion23128226
    esv2495318CNV Deletion19546169
    esv2604392CNV Loss19546169
    nsv438346CNV Loss16468122
    dgv36n47CNV Loss21111241
    nsv915080CNV Loss21882294
    nsv198CNV Loss15895083
    esv29947CNV Loss18421352
    nsv9907CNV Loss18304495

    Human Gene Mutation Database (HGMD): APOBEC3B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOBEC3B
    DNA2.0 Custom Variant and Variant Library Synthesis for APOBEC3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607110    OMIM disorders: --

    2 diseases for APOBEC3B:    
    About MalaCards
    human t-cell leukemia virus type 1    hepatitis b virus infection


    Find genes that share disorders with APOBEC3B           About GenesLikeMe

    Genetic Association Database (GAD): APOBEC3B
    Human Genome Epidemiology (HuGE) Navigator: APOBEC3B (4 documents)

    Export disorders for APOBEC3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOBEC3B gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with APOBEC3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1. (PubMed id 10469298)1, 2, 3, 9 Madsen P.P.... Celis J.E. (J. Invest. Dermatol. 1999)
    2. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PubMed id 11863358)1, 2, 3 Jarmuz A....Navaratnam N. (Genomics 2002)
    3. APOBEC3B deletion and risk of HIV-1 acquisition. (PubMed id 19698078)1, 4, 9 An P....Winkler C.A. (J. Infect. Dis. 2009)
    4. Population stratification of a common APOBEC gene deletion polymorphism. (PubMed id 17447845)1, 4, 9 Kidd J.M....Eichler E.E. (PLoS Genet. 2007)
    5. APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T- lymphotropic virus type 1. (PubMed id 22457529)1, 2 Ooms M.... Muenk C. (J. Virol. 2012)
    6. No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations. (PubMed id 20684727)1, 4 Itaya S....Kimura A. (J. Infect. Dis. 2010)
    7. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. (PubMed id 18304004)1, 2 Chiu Y.L. and Greene W.C. (Annu. Rev. Immunol. 2008)
    8. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2 Wichroski M.J.... Rana T.M. (PLoS Pathog. 2006)
    9. Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains. (PubMed id 17020885)1, 2 Hakata Y. and Landau N.R. (J. Biol. Chem. 2006)
    10. APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. (PubMed id 16527742)1, 2 Chen H.... Weitzman M.D. (Curr. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9582 HGNC: 17352 AceView: APOBEC3BandAPOBEC3A Ensembl:ENSG00000179750 euGenes: HUgn9582
    ECgene: APOBEC3B H-InvDB: APOBEC3B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APOBEC3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APOBEC3B gene:
    Search GeneIP for patents involving APOBEC3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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