Aliases for APOBEC3A_B Gene
Previous GeneCards Identifiers for APOBEC3A_B Gene
- GC22U900882
Summaries for APOBEC3A_B Gene
-
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. [provided by RefSeq, Jul 2012]
GeneCards Summary for APOBEC3A_B Gene
APOBEC3A_B (APOBEC3A And APOBEC3B Deletion Hybrid) is a Protein Coding gene. Among its related pathways are mRNA Editing- C to U Conversion and Gene Expression.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3A_B Gene
Genomics for APOBEC3A_B Gene
Regulatory Element Products
Genomic Location for APOBEC3A_B Gene
- Chromosome:
- 22
- Start:
- 68,431 bp from pter
- End:
- 78,547 bp from pter
- Size:
- 10,117 bases
- Orientation:
- Plus strand
Genomic View for APOBEC3A_B Gene
Genes around APOBEC3A_B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13 alternate reference locus by Entrez Gene
- 22q13 alternate reference locus by HGNC
Gene Density No data available for Regulatory Elements and RefSeq DNA sequence for APOBEC3A_B Gene
Proteins for APOBEC3A_B Gene
Post-translational modifications for APOBEC3A_B Gene
No Post-translational modifications
Other Protein References for APOBEC3A_B Gene
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for APOBEC3A_B
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Protein Products
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Assay Products
No data available for DME Specific Peptides for APOBEC3A_B Gene
Domains & Families for APOBEC3A_B Gene
Gene Families for APOBEC3A_B Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for APOBEC3A_B Gene
Function for APOBEC3A_B Gene
Animal Model Products
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CRISPR Products
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OriGene CRISPR knockouts for APOBEC3A_B
miRNA Products
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Inhibitory RNA Products
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for APOBEC3A_B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3A_B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOBEC3A_B Gene
Localization for APOBEC3A_B Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for APOBEC3A_B Gene
Pathways & Interactions for APOBEC3A_B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Editing- C to U Conversion |
.82
|
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for APOBEC3A_B Gene
4 Reactome pathways for APOBEC3A_B Gene
Interacting Proteins for APOBEC3A_B Gene
No data available for SIGNOR curated interactions for APOBEC3A_B Gene
Transcripts for APOBEC3A_B Gene
mRNA/cDNA for APOBEC3A_B Gene
- (1) REFSEQ mRNAs :
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC3A_B
miRNA Products
- Search ViGene Biosciences for APOBEC3A_B
Inhibitory RNA Products
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Clone Products
- VectorBuilder custom plasmid, inducible vectors for APOBEC3A_B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3A_B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Relevant External Links for APOBEC3A_B Gene
- GeneLoc Exon Structure for
- APOBEC3A_B
- ECgene alternative splicing isoforms for
- APOBEC3A_B
Expression for APOBEC3A_B Gene
NURSA nuclear receptor signaling pathways regulating expression of APOBEC3A_B Gene:
APOBEC3A_B
No Expression Related Data Available
Primer Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOBEC3A_B Gene
Orthologs for APOBEC3A_B Gene
No data available for Orthologs and Evolution for APOBEC3A_B Gene
Paralogs for APOBEC3A_B Gene
No data available for Paralogs for APOBEC3A_B Gene
Variants for APOBEC3A_B Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000213836 | -- | 38,960,249(+) | GAGAG(A/G)CCAGG | intron-variant | |
| rs1000706253 | -- | 38,955,854(+) | TCTTT(A/G)TCATC | upstream-variant-2KB | |
| rs1000924375 | -- | 38,961,754(+) | GAAAG(A/G)CCTTG | intron-variant | |
| rs1001254289 | -- | 38,958,881(+) | GTGCT(A/G)CCTCC | intron-variant | |
| rs1001421218 | -- | 38,957,523(+) | AGCTG(A/G)AGAAG | utr-variant-5-prime |
Relevant External Links for APOBEC3A_B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- APOBEC3A_B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for APOBEC3A_B Gene
Disorders for APOBEC3A_B Gene
Relevant External Links for APOBEC3A_B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- APOBEC3A_B
No disorders were found for APOBEC3A_B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC3A_B Gene
Publications for APOBEC3A_B Gene
- Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection. (PMID: 19788695) Abe H. … Chayama K. (Hepatol. Res. 2009) 2 3 64
- Population stratification of a common APOBEC gene deletion polymorphism. (PMID: 17447845) Kidd J.M. … Eichler E.E. (PLoS Genet. 2007) 2 3 64
- Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions. (PMID: 22272271) Henry M. … Vartanian J.P. (PLoS ONE 2012) 3 64
- Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. (PMID: 21123384) Bulliard Y. … Trono D. (J. Virol. 2011) 3 64
- APOBEC3A can activate the DNA damage response and cause cell-cycle arrest. (PMID: 21460793) Landry S. … Weitzman M.D. (EMBO Rep. 2011) 3 64
Products for APOBEC3A_B Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for APOBEC3A_B Gene
- (1) GeneCards
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