Free for academic non-profit institutions. Other users need a Commercial license

Aliases for APOBEC3A_B Gene

Aliases for APOBEC3A_B Gene

  • APOBEC3A And APOBEC3B Deletion Hybrid 2 3

External Ids for APOBEC3A_B Gene

Previous GeneCards Identifiers for APOBEC3A_B Gene

  • GC22U900882

Summaries for APOBEC3A_B Gene

Entrez Gene Summary for APOBEC3A_B Gene

  • This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. [provided by RefSeq, Jul 2012]

GeneCards Summary for APOBEC3A_B Gene

APOBEC3A_B (APOBEC3A And APOBEC3B Deletion Hybrid) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3A_B Gene

Genomics for APOBEC3A_B Gene

Genomic Location for APOBEC3A_B Gene

Chromosome:
22
Start:
68,431 bp from pter
End:
78,547 bp from pter
Size:
10,117 bases
Orientation:
Plus strand

Genomic View for APOBEC3A_B Gene

Genes around APOBEC3A_B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
  • 22q13 alternate reference locus by Entrez Gene
  • 22q13 alternate reference locus by HGNC
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for APOBEC3A_B Gene

Proteins for APOBEC3A_B Gene

Post-translational modifications for APOBEC3A_B Gene

No Post-translational modifications

Other Protein References for APOBEC3A_B Gene

REFSEQ proteins:

No data available for DME Specific Peptides for APOBEC3A_B Gene

Domains & Families for APOBEC3A_B Gene

Gene Families for APOBEC3A_B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APOBEC3A_B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for APOBEC3A_B Gene

Function for APOBEC3A_B Gene

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOBEC3A_B Gene

Localization for APOBEC3A_B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for APOBEC3A_B Gene

Pathways & Interactions for APOBEC3A_B Gene

SuperPathways for APOBEC3A_B Gene

No Data Available

Interacting Proteins for APOBEC3A_B Gene

Gene Ontology (GO) - Biological Process for APOBEC3A_B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for APOBEC3A_B Gene

Drugs & Compounds for APOBEC3A_B Gene

No Compound Related Data Available

Transcripts for APOBEC3A_B Gene

mRNA/cDNA for APOBEC3A_B Gene

(1) REFSEQ mRNAs :

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC3A_B Gene

No ASD Table

Relevant External Links for APOBEC3A_B Gene

GeneLoc Exon Structure for
APOBEC3A_B
ECgene alternative splicing isoforms for
APOBEC3A_B

Expression for APOBEC3A_B Gene

NURSA nuclear receptor signaling pathways regulating expression of APOBEC3A_B Gene:

APOBEC3A_B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for APOBEC3A_B Gene

Orthologs for APOBEC3A_B Gene

No data available for Orthologs and Evolution for APOBEC3A_B Gene

Paralogs for APOBEC3A_B Gene

No data available for Paralogs for APOBEC3A_B Gene

Variants for APOBEC3A_B Gene

Sequence variations from dbSNP and Humsavar for APOBEC3A_B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5995640 -- 38,953,612(+) GGAAG(A/G)GAGGG intron-variant, utr-variant-5-prime
rs5995641 -- 38,954,945(+) ACCTC(C/T)GTTCT intron-variant, utr-variant-5-prime
rs5995642 -- 38,955,032(+) CTCAC(C/T)CAGTC intron-variant, utr-variant-5-prime
rs6001337 -- 38,953,341(+) GTGTC(A/G)GAGGC intron-variant, utr-variant-5-prime
rs6001338 -- 38,953,771(+) TGGAG(C/T)GGGAG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for APOBEC3A_B Gene

Variant ID Type Subtype PubMed ID
dgv172n111 CNV deletion 26073780
dgv36n47 CNV loss 21111241
dgv4568n100 CNV loss 25217958
dgv4569n100 CNV loss 25217958
dgv4570n100 CNV loss 25217958
dgv4571n100 CNV loss 25217958
dgv770n67 CNV loss 20364138
dgv8106n54 CNV loss 21841781
dgv8107n54 CNV loss 21841781
dgv833e199 CNV deletion 23128226
esv2495318 CNV deletion 19546169
esv2604392 CNV loss 19546169
esv2658587 CNV deletion 23128226
esv2670964 CNV deletion 23128226
esv2724238 CNV deletion 23290073
esv2724240 CNV deletion 23290073
esv2760711 CNV loss 21179565
esv2763703 CNV loss 21179565
esv28999 CNV loss 19812545
esv29947 CNV loss 18421352
esv33846 CNV gain+loss 17666407
esv3558165 CNV deletion 23714750
esv3568392 CNV loss 25503493
esv3584501 CNV gain 24956385
esv3584780 CNV loss 24956385
esv3584781 CNV loss 24956385
esv3647746 CNV loss 21293372
esv3647747 CNV loss 21293372
esv3647748 CNV gain 21293372
esv3647749 CNV loss 21293372
esv3647750 CNV loss 21293372
esv6265 CNV loss 19470904
esv998756 CNV deletion 20482838
nsv1055716 CNV loss 25217958
nsv1056597 CNV loss 25217958
nsv1061176 CNV gain+loss 25217958
nsv1062874 CNV gain+loss 25217958
nsv198 CNV deletion 15895083
nsv3627 CNV deletion 18451855
nsv438346 CNV loss 16468122
nsv442797 CNV loss 18776908
nsv472943 CNV novel sequence insertion 20440878
nsv482077 CNV gain 20164927
nsv589021 CNV loss 21841781
nsv589030 CNV loss 21841781
nsv589031 CNV loss 21841781
nsv829221 CNV loss 20364138
nsv829223 CNV loss 20364138
nsv829224 CNV loss 20364138
nsv829225 CNV loss 20364138
nsv964630 OTHER complex 23825009
nsv979675 CNV duplication 23825009
nsv979676 CNV duplication 23825009
nsv9907 CNV loss 18304495
nsv9908 CNV loss 18304495

Relevant External Links for APOBEC3A_B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOBEC3A_B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for APOBEC3A_B Gene

Disorders for APOBEC3A_B Gene

Relevant External Links for APOBEC3A_B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOBEC3A_B

No disorders were found for APOBEC3A_B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC3A_B Gene

Publications for APOBEC3A_B Gene

  1. Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection. (PMID: 19788695) Abe H. … Chayama K. (Hepatol. Res. 2009) 2 3 65
  2. Population stratification of a common APOBEC gene deletion polymorphism. (PMID: 17447845) Kidd J.M. … Eichler E.E. (PLoS Genet. 2007) 2 3 65
  3. Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions. (PMID: 22272271) Henry M. … Vartanian J.P. (PLoS ONE 2012) 3 65
  4. Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. (PMID: 21123384) Bulliard Y. … Trono D. (J. Virol. 2011) 3 65
  5. APOBEC3A can activate the DNA damage response and cause cell-cycle arrest. (PMID: 21460793) Landry S. … Weitzman M.D. (EMBO Rep. 2011) 3 65

Products for APOBEC3A_B Gene

Sources for APOBEC3A_B Gene

Content
Loading form....