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APOBEC3A_B Gene

protein-coding   GIFtS: 13
GCID: GC22U900882

APOBEC3A And APOBEC3B Deletion Hybrid

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
APOBEC3A And APOBEC3B Deletion Hybrid1 2
Probable DNA DC->DU-Editing Enzyme APOBEC-3A2

External Ids:    HGNC: 441961   Entrez Gene: 1009131872   

Export aliases for APOBEC3A_B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOBEC3A_B Gene:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found
in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins
that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein
encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in
immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is
deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other
mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The
protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that
results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene
APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have
the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. (provided by RefSeq, Jul 2012)

GeneCards Summary for APOBEC3A_B Gene:
APOBEC3A_B (APOBEC3A and APOBEC3B deletion hybrid) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for APOBEC3A_B
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Epigenetics:
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Genomic Location:
Chromosome:22   

Entrez Gene cytogenetic band: 22q13 alternate reference locus   HGNC cytogenetic band: 22q13 alternate reference locus

GeneLoc information about chromosome 22        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB: --
REFSEQ proteins: NP_001180218.1  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
APOBEC: Apolipoprotein B mRNA editing enzymes

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for APOBEC3A_B gene: 
NM_001193289.1  

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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

APOBEC3A_B Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for APOBEC3A_B (see all 938)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs119124241,2
C,F,H--22322113(+) GGAACC/GGAGAA 1 -- ut519Minor allele frequency- G:0.05NS EA NA WA CSA 634
rs1478035381,2
--22322663(+) TTCATA/GCCCAG 1 -- int10--------
rs1411918811,2
--22322677(+) TACTCA/GAAATG 1 -- int10--------
rs723218461,2
C--22322830(+) CTCTT-/TCCC  
        
CCCTC
1 -- int10--------
rs1447586231,2
C--22322996(+) CTTCC-/TTTCTCT 1 -- int10--------
rs716689461,2
C--22322998(+) TCCTC-/TT    
   
/TTCT
TCTTT
1 -- int10--------
rs2020172021,2
C--22323011(+) CTTTC-/TTTC  
        
CTTTC
1 -- int10--------
rs2015236631,2
--22323114(+) TTCTT-/TTCC  
        
TTCCT
1 -- int10--------
rs1378817881,2
C--22323145(+) TCTTTC/TCTTCT 1 -- int10--------
rs1131391441,2
C--22323204(+) TCTCTC/TTCTCT 1 -- int10--------
Structural Variations
      Database of Genomic Variants (DGV) variations for APOBEC3A_B: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing APOBEC3A_B
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for APOBEC3A_B gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with APOBEC3A_B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection. (PubMed id 19788695)1, 3 Abe H....Chayama K. (Hepatol. Res. 2009)
  2. Population stratification of a common APOBEC gene deletion polymorphism. (PubMed id 17447845)1, 3 Kidd J.M....Eichler E.E. (PLoS Genet. 2007)
  3. Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions. (PubMed id 22272271)1 Henry M....Vartanian J.P. (PLoS ONE 2012)
  4. APOBEC3A can activate the DNA damage response and cause cell-cycle arrest. (PubMed id 21460793)1 Landry S.... Weitzman M.D. (EMBO Rep. 2011)
  5. Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. (PubMed id 21123384)1 Bulliard Y.... Trono D. (J. Virol. 2011)
  6. Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages. (PubMed id 21957290)1 Koning F.A....Malim M.H. (J. Virol. 2011)
  7. APOBEC3 proteins mediate the clearance of foreign DNA from human cells. (PubMed id 20062055)1 Stenglein M.D.... Harris R.S. (Nat. Struct. Mol. Biol. 2010)
  8. Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes. (PubMed id 20178977)1 Berger A....Flory E. (J. Biol. Chem. 2010)
  9. Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms. (PubMed id 20615867)1 Thielen B.K....Lingappa J.R. (J. Biol. Chem. 2010)
  10. Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase. (PubMed id 19461882)1 Narvaiza I.... Weitzman M.D. (PLoS Pathog. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100913187 HGNC: 44196 euGenes: HUgn100913187 ECgene: APOBEC3A_B H-InvDB: APOBEC3A_B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for APOBEC3A_B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for APOBEC3A_B gene:
Search GeneIP for patents involving APOBEC3A_B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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