APOBEC3A_B Gene
protein-coding GIFtS: 9
GCID: GC22U900882
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APOBEC3A and APOBEC3B deletion hybrid
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Aliases
for APOBEC3A_B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
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| Aliases |
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| APOBEC3A And APOBEC3B Deletion Hybrid1 2 | | Probable DNA DC->DU-Editing Enzyme APOBEC-3A2 |
Export aliases for APOBEC3A_B gene to outside databases |
Summaries
for APOBEC3A_B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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Entrez Gene summary for APOBEC3A_B:
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in acluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that arestructurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded bythis gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, byrestricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination offoreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are alsothought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this geneis the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion ofapproximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of thedeletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region ofAPOBEC3A, but the 3' UTR of APOBEC3B. (provided by RefSeq, Jul 2012)
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Genomic Views
for APOBEC3A_B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
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| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for APOBEC3A_B
Other transcription factors
Search SABiosciences Chromatin IP Primers for APOBEC3A_B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC3A_B |
Genomic Location:
Chromosome:22
Entrez Gene cytogenetic band: 22q13 GRCh37 novel patch HGNC cytogenetic band: 22q13 GRCh37 novel patchGeneLoc information about chromosome 22 |
Proteins
for APOBEC3A_B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
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UniProtKB: --
APOBEC3A_B Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001180218.1
Human Recombinant Protein Products:
Antibody Products for APOBEC3A_B:
Assay Products for APOBEC3A_B: |
Protein
Domains /
Families
for APOBEC3A_B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
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Function
for APOBEC3A_B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
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Pathways & Interactions
for APOBEC3A_B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOBEC3A_B
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Drugs & Compounds
for APOBEC3A_B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for APOBEC3A_B
Search CenterWatch for drugs/clinical trials and news about APOBEC3A_B 
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Transcripts
for APOBEC3A_B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
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REFSEQ mRNAs for APOBEC3A_B gene: NM_001193289.1
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Expression
for APOBEC3A_B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for APOBEC3A_B
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat APOBEC3A_B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOBEC3A_B | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOBEC3A_B |
Orthologs
for APOBEC3A_B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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Paralogs
for APOBEC3A_B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for APOBEC3A_B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for APOBEC3A_B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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APOBEC3A_B for disorders About GeneDecksing
4  diseases for APOBEC3A_B: About MalaCardshepatitis b virus infection hepatitis b immunodeficiency hepatitis
Export disorders for APOBEC3A_B gene to outside databases
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Publications
for APOBEC3A_B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for APOBEC3A_B gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with APOBEC3A_B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Effects of structural variations of APOBEC3A and APOB EC3B genes in chronic hepatitis B virus infection. (PubMed id 19788695)1, 3 Abe H....Chayama K. (2009)
- Population stratification of a common APOBEC gene deletion polymorphism. (PubMed id 17447845)1, 3 Kidd J.M....Eichler E.E. (2007)
- Evolution of the primate APOBEC3A cytidine deaminase g ene and identification of related coding regions. (PubMed id 22272271)1 Henry M....Vartanian J.P. (2012)
- APOBEC3A can activate the DNA damage response and cau se cell-cycle arrest. (PubMed id 21460793)1 Landry S....Weitzman M.D. (2011)
- Structure-function analyses point to a polynucleotide -accommodating groove essential for APOBEC3A restriction activities. (PubMed id 21123384)1 Bulliard Y....Trono D. (2011)
- Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages. (PubMed id 21957290)1 Koning F.A....Malim M.H. (2011)
- APOBEC3 proteins mediate the clearance of foreign DNA from human cells. (PubMed id 20062055)1 Stenglein M.D....Harris R.S. (2010)
- Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient le ntivirus infection of monocytes. (PubMed id 20178977)1 Berger A....Flory E. (2010)
- Innate immune signaling induces high levels of TC-spe cific deaminase activity in primary monocyte-derived cells through expression o f APOBEC3A isoforms. (PubMed id 20615867)1 Thielen B.K....Lingappa J.R. (2010)
- Deaminase-independent inhibition of parvoviruses by t he APOBEC3A cytidine deaminase. (PubMed id 19461882)1 Narvaiza I....Weitzman M.D. (2009)
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External Searches for APOBEC3A_B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing APOBEC3A_B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing APOBEC3A_B gene
(According to HUGE)
About This Section
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Specialized Databases showing APOBEC3A_B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for APOBEC3A_B gene:
Search GeneIP for patents involving APOBEC3A_B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for APOBEC3A_B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APOBEC3A_B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOBEC3A_B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC3A_B | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOBEC3A_B | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOBEC3A_B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOBEC3A_B |
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 | | | | |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat APOBEC3A_B |
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