Free for academic non-profit institutions. Other users need a Commercial license

Aliases for APOBEC3A_B Gene

Aliases for APOBEC3A_B Gene

  • APOBEC3A And APOBEC3B Deletion Hybrid 2 3

External Ids for APOBEC3A_B Gene

Previous GeneCards Identifiers for APOBEC3A_B Gene

  • GC22U900882

Summaries for APOBEC3A_B Gene

Entrez Gene Summary for APOBEC3A_B Gene

  • This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. The protein encoded by this gene is the same as that encoded by APOBEC3A; however, this gene is a hybrid gene that results from the deletion of approximately 29.5 kb of sequence between the APOBEC3A gene and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion hybrid is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. [provided by RefSeq, Jul 2012]

GeneCards Summary for APOBEC3A_B Gene

APOBEC3A_B (APOBEC3A And APOBEC3B Deletion Hybrid) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3A_B Gene

Genomics for APOBEC3A_B Gene

Genomic Location for APOBEC3A_B Gene

Chromosome:
22
Start:
68,431 bp from pter
End:
78,547 bp from pter
Size:
10,117 bases
Orientation:
Plus strand

Genomic View for APOBEC3A_B Gene

Genes around APOBEC3A_B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
  • 22q13 alternate reference locus by Entrez Gene
  • 22q13 alternate reference locus by HGNC
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for APOBEC3A_B Gene

Proteins for APOBEC3A_B Gene

Post-translational modifications for APOBEC3A_B Gene

No Post-translational modifications

Other Protein References for APOBEC3A_B Gene

REFSEQ proteins:

No data available for DME Specific Peptides for APOBEC3A_B Gene

Domains & Families for APOBEC3A_B Gene

Gene Families for APOBEC3A_B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APOBEC3A_B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for APOBEC3A_B Gene

Function for APOBEC3A_B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOBEC3A_B Gene

Localization for APOBEC3A_B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for APOBEC3A_B Gene

Pathways & Interactions for APOBEC3A_B Gene

SuperPathways for APOBEC3A_B Gene

No Data Available

Interacting Proteins for APOBEC3A_B Gene

Gene Ontology (GO) - Biological Process for APOBEC3A_B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for APOBEC3A_B Gene

Drugs & Compounds for APOBEC3A_B Gene

No Compound Related Data Available

Expression for APOBEC3A_B Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for APOBEC3A_B Gene

Orthologs for APOBEC3A_B Gene

No data available for Orthologs and Evolution for APOBEC3A_B Gene

Paralogs for APOBEC3A_B Gene

No data available for Paralogs for APOBEC3A_B Gene

Variants for APOBEC3A_B Gene

Sequence variations from dbSNP and Humsavar for APOBEC3A_B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs4821844 -- 38,954,574(+) CTGAG(A/G)CTGTC intron-variant, utr-variant-5-prime
rs5757402 -- 38,954,067(+) ACACA(C/T)AAGCA intron-variant, utr-variant-5-prime
rs5995640 -- 38,953,612(+) GGAAG(A/G)GAGGG intron-variant, utr-variant-5-prime
rs5995642 -- 38,955,032(+) CTCAC(C/T)CAGTC intron-variant, utr-variant-5-prime
rs6001337 -- 38,953,341(+) GTGTC(A/G)GAGGC intron-variant, utr-variant-5-prime

Relevant External Links for APOBEC3A_B Gene

HapMap Linkage Disequilibrium report
APOBEC3A_B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for APOBEC3A_B Gene

Disorders for APOBEC3A_B Gene

Relevant External Links for APOBEC3A_B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOBEC3A_B

No disorders were found for APOBEC3A_B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC3A_B Gene

Publications for APOBEC3A_B Gene

  1. Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection. (PMID: 19788695) Abe H. … Chayama K. (Hepatol. Res. 2009) 2 3 67
  2. Population stratification of a common APOBEC gene deletion polymorphism. (PMID: 17447845) Kidd J.M. … Eichler E.E. (PLoS Genet. 2007) 2 3
  3. Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions. (PMID: 22272271) Henry M. … Vartanian J.P. (PLoS ONE 2012) 3
  4. Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. (PMID: 21123384) Bulliard Y. … Trono D. (J. Virol. 2011) 3
  5. APOBEC3A can activate the DNA damage response and cause cell-cycle arrest. (PMID: 21460793) Landry S. … Weitzman M.D. (EMBO Rep. 2011) 3

Products for APOBEC3A_B Gene

Sources for APOBEC3A_B Gene

Back to Top

Content