Aliases for APOBEC3A Gene
Aliases for APOBEC3A Gene
External Ids for APOBEC3A Gene
- HGNC: 17343
- Entrez Gene: 200315
- Ensembl: ENSG00000128383
- OMIM: 607109
- UniProtKB: P31941
Previous GeneCards Identifiers for APOBEC3A Gene
- GC22P035968
- GC22P037591
- GC22P037596
- GC22P037678
- GC22P039348
- GC22Pr39368
Summaries for APOBEC3A Gene
-
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for APOBEC3A Gene
APOBEC3A (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3A) is a Protein Coding gene. Among its related pathways are mRNA Editing- C to U Conversion and Gene Expression. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines and deoxycytidine deaminase activity. An important paralog of this gene is APOBEC3B.
UniProtKB/Swiss-Prot for APOBEC3A Gene
-
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC3A Gene
Genomics for APOBEC3A Gene
Regulatory Elements for APOBEC3A Gene
- Transcription factor binding sites by QIAGEN in the APOBEC3A gene promoter:
Regulatory Element Products
Genomic Location for APOBEC3A Gene
- Chromosome:
- 22
- Start:
- 38,952,741 bp from pter
- End:
- 38,992,778 bp from pter
- Size:
- 40,038 bases
- Orientation:
- Plus strand
Genomic View for APOBEC3A Gene
- Cytogenetic band:
-
- 22q13.1 by Ensembl
- 22q13.1 by Entrez Gene
- 22q13.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOBEC3A Gene
Proteins for APOBEC3A Gene
-
Protein details for APOBEC3A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31941-ABC3A_HUMAN
- Recommended name:
- DNA dC->dU-editing enzyme APOBEC-3A
- Protein Accession:
- P31941
- A0AVM1
- Q12807
- Q5JZ93
- Q9UH18
Protein attributes for APOBEC3A Gene
- Size:
- 199 amino acids
- Molecular mass:
- 23012 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Interacts with AGO2. Interacts with TRIB3 (via N-terminus).
- Miscellaneous:
-
- It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22.
Three dimensional structures from OCA and Proteopedia for APOBEC3A Gene
Protein Expression for APOBEC3A Gene
Selected DME Specific Peptides for APOBEC3A Gene
- P31941:
-
- EHSQALSGRL
- FTSNFNN
- PFQPWDGL
Post-translational modifications for APOBEC3A Gene
Other Protein References for APOBEC3A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Protein Products
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Assay Products
- antibodies-online Kits for APOBEC3A: See all 29
Domains & Families for APOBEC3A Gene
Gene Families for APOBEC3A Gene
Protein Domains for APOBEC3A Gene
Suggested Antigen Peptide Sequences for APOBEC3A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31941- Family:
-
- Belongs to the cytidine and deoxycytidylate deaminase family.
Function for APOBEC3A Gene
Molecular function for APOBEC3A Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cytidine + H(2)O = uridine + NH(3).
- UniProtKB/Swiss-Prot Function:
- DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by interferon and CpG single-stranded DNA (at protein level).
Enzyme Numbers (IUBMB) for APOBEC3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004126 | cytidine deaminase activity | IMP | 20062055 |
| GO:0005515 | protein binding | IPI | 22915799 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for APOBEC3A Gene
- GenomeRNAi human phenotypes for APOBEC3A:
Animal Model Products
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ViGene Biosciences lentiviral particle packaged cDNA for APOBEC3A gene
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CRISPR Products
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miRNA for APOBEC3A Gene
- miRTarBase miRNAs that target APOBEC3A
-
- hsa-mir-6848-3p (MIRT679797)
- hsa-mir-6843-3p (MIRT679798)
- hsa-mir-6878-3p (MIRT679799)
- hsa-mir-640 (MIRT679800)
- hsa-mir-378a-5p (MIRT679801)
- hsa-mir-6744-3p (MIRT679802)
- hsa-mir-4757-5p (MIRT679803)
- hsa-mir-6821-3p (MIRT679804)
- hsa-mir-6790-3p (MIRT679805)
- hsa-mir-1976 (MIRT679806)
- hsa-mir-3653-5p (MIRT679807)
- hsa-mir-519d-5p (MIRT679808)
- hsa-mir-212-5p (MIRT679809)
miRNA Products
- Search ViGene Biosciences for APOBEC3A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOBEC3A
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for APOBEC3A
-
ViGene Biosciences adenoviral particle packaged cDNA for APOBEC3A gene
-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOBEC3A Gene
Localization for APOBEC3A Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOBEC3A Gene
- Nucleus. Cytoplasm.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 16527742 |
| GO:0005737 | cytoplasm | IDA,IEA | 16527742 |
Pathways & Interactions for APOBEC3A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Editing- C to U Conversion |
.82
|
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for APOBEC3A Gene
4 Reactome pathways for APOBEC3A Gene
Interacting Proteins for APOBEC3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009972 | cytidine deamination | IEA | -- |
| GO:0010529 | negative regulation of transposition | IDA | 16527742 |
| GO:0044356 | clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine | IDA | 20062055 |
| GO:0045071 | negative regulation of viral genome replication | IDA | 16527742 |
| GO:0045087 | innate immune response | IEA,IDA | 21123384 |
No data available for SIGNOR curated interactions for APOBEC3A Gene
Drugs & Compounds for APOBEC3A Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Ammonia |
|
7664-41-7 |
|
Transcripts for APOBEC3A Gene
mRNA/cDNA for APOBEC3A Gene
- (2) REFSEQ mRNAs :
- (55) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
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OriGene CRISPR knockouts for APOBEC3A
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Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC3A
- GenScript: Design CRISPR guide RNA sequences for APOBEC3A
miRNA Products
- Search ViGene Biosciences for APOBEC3A
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOBEC3A
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ViGene Biosciences ready-to-package AAV shRNAs for APOBEC3A gene
Clone Products
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OriGene ORF clones in human for APOBEC3A
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- VectorBuilder custom plasmid, inducible vectors for APOBEC3A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for APOBEC3A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for APOBEC3A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOBEC3A Gene
NURSA nuclear receptor signaling pathways regulating expression of APOBEC3A Gene:
APOBEC3AmRNA Expression by UniProt/SwissProt for APOBEC3A Gene:
P31941-ABC3A_HUMANEvidence on tissue expression from TISSUES for APOBEC3A Gene
- Skin(4.2)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for APOBEC3A
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APOBEC3A Gene
Orthologs for APOBEC3A Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | APOBEC3A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | APOBEC3A 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | APOBEC3A 34 |
|
||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany |
- Species where no ortholog for APOBEC3A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for APOBEC3A Gene
Paralogs for APOBEC3A Gene
(10) SIMAP similar genes for APOBEC3A Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for APOBEC3A Gene
Variants for APOBEC3A Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000213836 | -- | 38,960,249(+) | GAGAG(A/G)CCAGG | intron-variant | |
| rs1000706253 | -- | 38,955,854(+) | TCTTT(A/G)TCATC | upstream-variant-2KB | |
| rs1000924375 | -- | 38,961,754(+) | GAAAG(A/G)CCTTG | intron-variant | |
| rs1001254289 | -- | 38,958,881(+) | GTGCT(A/G)CCTCC | intron-variant | |
| rs1001421218 | -- | 38,957,523(+) | AGCTG(A/G)AGAAG | utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv172n111 | CNV | deletion | 26073780 |
| dgv36n47 | CNV | loss | 21111241 |
| dgv4568n100 | CNV | loss | 25217958 |
| dgv4569n100 | CNV | loss | 25217958 |
| dgv770n67 | CNV | loss | 20364138 |
| dgv833e199 | CNV | deletion | 23128226 |
| esv2495318 | CNV | deletion | 19546169 |
| esv2604392 | CNV | loss | 19546169 |
| esv2724238 | CNV | deletion | 23290073 |
| esv2760711 | CNV | loss | 21179565 |
| esv2763703 | CNV | loss | 21179565 |
| esv28999 | CNV | loss | 19812545 |
| esv29947 | CNV | loss | 18421352 |
| esv33846 | CNV | gain+loss | 17666407 |
| esv3568392 | CNV | loss | 25503493 |
| esv3647746 | CNV | loss | 21293372 |
| nsv1056597 | CNV | loss | 25217958 |
| nsv198 | CNV | deletion | 15895083 |
| nsv3627 | CNV | deletion | 18451855 |
| nsv589021 | CNV | loss | 21841781 |
| nsv829221 | CNV | loss | 20364138 |
| nsv964630 | OTHER | complex | 23825009 |
| nsv979675 | CNV | duplication | 23825009 |
| nsv9907 | CNV | loss | 18304495 |
Relevant External Links for APOBEC3A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- APOBEC3A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC3A Gene
Disorders for APOBEC3A Gene
Relevant External Links for APOBEC3A
No disorders were found for APOBEC3A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC3A Gene
Publications for APOBEC3A Gene
- Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1. (PMID: 10469298) Madsen P.P. … Celis J.E. (J. Invest. Dermatol. 1999) 2 3 4 22 64
- APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons. (PMID: 16527742) Chen H. … Weitzman M.D. (Curr. Biol. 2006) 3 4 22 64
- An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. (PMID: 11863358) Jarmuz A. … Navaratnam N. (Genomics 2002) 2 3 4 64
- APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T- lymphotropic virus type 1. (PMID: 22457529) Ooms M. … Muenk C. (J. Virol. 2012) 3 4 64
- HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. (PMID: 22915799) Phalora P.K. … Malim M.H. (J. Virol. 2012) 3 4 64
Products for APOBEC3A Gene
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- Horizon Cell Lines for APOBEC3A
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOBEC3A
- VectorBuilder custom plasmid, inducible vectors for APOBEC3A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC3A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for APOBEC3A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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