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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOBEC2 Gene

protein-coding   GIFtS: 57
GCID: GC06P041020

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 21 2     Probable C->U-Editing Enzyme APOBEC-22
ARCD12     EC 3.5.4.-3
ARP12     EC 3.5.48
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 22     

External Ids:    HGNC: 6051   Entrez Gene: 109302   Ensembl: ENSG000001247017   OMIM: 6047975   UniProtKB: Q9Y2353   

Export aliases for APOBEC2 gene to outside databases

Previous GC identifers: GC06P041023 GC06P041067 GC06P041128 GC06P040738


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for APOBEC2 Gene: 
APOBEC2 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2) is a protein-coding gene. Diseases associated with APOBEC2 include tonsillitis, and thyroiditis. GO annotations related to this gene include cytidine deaminase activity and RNA binding. An important paralog of this gene is APOBEC3G.

UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
Function: Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display
detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic
regulation of gene expression through the process of active DNA demethylation

Gene Wiki entry for APOBEC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOBEC2 gene promoter:
         AP-4   CUTL1   Roaz   GATA-1   AP-2beta   Pax-4a   NF-kappaB1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOBEC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for APOBEC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21

APOBEC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041020:  view genomic region     (about GC identifiers)

Start:
41,020,940 bp from pter      End:
41,032,630 bp from pter
Size:
11,691 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235 (See protein sequence)
Recommended Name: Probable C->U-editing enzyme APOBEC-2  
Size: 224 amino acids; 25703 Da
Cofactor: Zinc (By similarity)
Subunit: Homotetramer
1 PDB 3D structure from and Proteopedia for APOBEC2:
2NYT (3D)    
Secondary accessions: B2R899 Q53F28 Q5TGU5 Q5TGU6

Explore the universe of human proteins at neXtProt for APOBEC2: NX_Q9Y235

Explore proteomics data for APOBEC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y235

  • 4 DME Specific Peptides for APOBEC2 (Q9Y235)
     GYLEDEHA  HAEEAFFN  LPPFEIVTG  VTWYVSSSPCAACADRI 

    APOBEC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APOBEC2 Protein Expression
    REFSEQ proteins: NP_006780.1  
    ENSEMBL proteins: 
     ENSP00000244669  

    Human Recombinant Protein Products for APOBEC2: 
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    Novus Biologicals APOBEC2 Proteins
    Novus Biologicals APOBEC2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for APOBEC2 


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    LSBio Antibodies in human, mouse, rat for APOBEC2 

    Assay Products for APOBEC2: 
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    Cloud-Clone Corp. ELISAs for APOBEC2 
    Cloud-Clone Corp. CLIAs for APOBEC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    APOBEC: Apolipoprotein B mRNA editing enzymes

    3 InterPro protein domains:
     IPR016193 Cytidine_deaminase-like
     IPR007904 APOBEC_C
     IPR013158 APOBEC_N

    Graphical View of Domain Structure for InterPro Entry Q9Y235

    ProtoNet protein and cluster: Q9Y235

    2 Blocks protein domains:
    IPB002125 Cytidine/deoxycytidylate deaminase
    IPB007904 APOBEC-like


    UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family


    APOBEC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABEC2_HUMAN, Q9Y235
    Function: Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display
    detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic
    regulation of gene expression through the process of active DNA demethylation

         Genatlas biochemistry entry for APOBEC2:
    apolipoprotein B,mRNA editing enzyme,catalytic polypeptide 2,expressed exclusively in heart and skeletal muscle

         Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS10403781
    GO:0003824catalytic activity ----
    GO:0004126cytidine deaminase activity TAS10403781
    GO:0008270zinc ion binding IEA--
    GO:0016814hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines ----
         
    APOBEC2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for APOBEC2:
     Decreased Wnt reporter activit  Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Apobec2):
     growth/size  normal  skeleton 

    APOBEC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Apobec2tm1Msn for APOBEC2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for APOBEC2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APOBEC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOBEC2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOBEC2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOBEC2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate APOBEC2 (see all 11):
    hsa-miR-30c-2* hsa-miR-409-3p hsa-miR-4267 hsa-miR-4316 hsa-miR-214 hsa-miR-885-3p hsa-miR-593 hsa-miR-30c-1*
    SwitchGear 3'UTR luciferase reporter plasmidAPOBEC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for APOBEC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOBEC2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of APOBEC2

    Clone
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    OriGene ORF clones in mouse, rat for APOBEC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: APOBEC2 (NM_006789)
    Sino Biological Human cDNA Clone for APOBEC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOBEC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC2
    Sirion Biotech Customized lentivirus for stable overexpression of APOBEC2 
                         Customized lentivirus expression plasmids for stable overexpression of APOBEC2 

    Cell Line
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    Search LifeMap BioReagents cell lines for APOBEC2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOBEC2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for APOBEC2 (Q9Y2353 ENSP000002446694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBEC1P412383, ENSP000002293044I2D: score=2 STRING: ENSP00000229304
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0009972cytidine deamination TAS10403781
    GO:0016556mRNA modification IEA--
    GO:0080111DNA demethylation IDA--

    APOBEC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOBEC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOBEC2 (ABEC2)

    3 Novoseek inferred chemical compound relationships for APOBEC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 86.6 10 11698249 (3), 10403781 (2), 16720547 (1), 16055735 (1) (see all 6)
    retinoic acid 22.1 1 8119938 (1)
    steroid 5.65 3 1639815 (2), 8505324 (1)

    Search CenterWatch for drugs/clinical trials and news about APOBEC2 / ABEC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APOBEC2 gene: 
    NM_006789.3  

    Unigene Cluster for APOBEC2:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
    Hs.555915  [show with all ESTs]
    Unigene Representative Sequence: NM_006789
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244669(uc003opl.3 uc010jxf.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOBEC2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate APOBEC2 (see all 11):
    hsa-miR-30c-2* hsa-miR-409-3p hsa-miR-4267 hsa-miR-4316 hsa-miR-214 hsa-miR-885-3p hsa-miR-593 hsa-miR-30c-1*
    SwitchGear 3'UTR luciferase reporter plasmidAPOBEC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for APOBEC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOBEC2
    Clone
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    OriGene clones in human, mouse for APOBEC2 (see all 6)
    OriGene ORF clones in mouse, rat for APOBEC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: APOBEC2 (NM_006789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOBEC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC2
    Sirion Biotech Customized lentivirus for stable overexpression of APOBEC2 
                         Customized lentivirus expression plasmids for stable overexpression of APOBEC2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for APOBEC2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOBEC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOBEC2

    Additional mRNA sequence: 

    AF086496.1 AF161698.1 AK223461.1 AK300689.1 AK308197.1 AK310006.1 AK313288.1 BC047767.2 
    BC069688.1 BC069764.1 

    3 DOTS entries:

    DT.440666  DT.92422005  DT.95366225 

    24/74 AceView cDNA sequences (see all 74):

    BF204767 AI694918 AI204314 BM724377 BC069764 AI126842 F35775 AI141858 
    BC069688 NM_006789 BF223030 CA942892 F27745 N91784 AA708834 BF205273 
    AF161698 BF221720 F28502 AF086496 CA942652 AA369658 F24691 AW044334 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOBEC2 expression in normal human tissues (normalized intensities)      APOBEC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCCAGTC
    APOBEC2 Expression
    About this image


    APOBEC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
             heart muscle ; myocytes   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             skeletal muscle ; myocytes   
             vastus lateralis   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Bone (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer

    See APOBEC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOBEC2

    SOURCE GeneReport for Unigene cluster: Hs.555915

    UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
    Tissue specificity: Expressed exclusively in heart and skeletal muscle

        SABiosciences Custom PCR Arrays for APOBEC2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for APOBEC2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apobec21 , 5 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 less1, 5 87.95(n)1
    90.62(a)1
      17 (24.02 cM)5
    118111  NM_009694.31  NP_033824.11 
     484192315 
    chicken
    (Gallus gallus)
    Aves APOBEC21 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 less 73.58(n)
    78.8(a)
      419915  XM_418038.2  XP_418038.1 
    lizard
    (Anolis carolinensis)
    Reptilia APOBEC26
    Uncharacterized protein
    64(a)
    1 ↔ 1
    4(123361945-123363469)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.58762 Xenopus laevis transcribed sequence with weak similarity to protein refNP_006780.1 (H.sapiens) apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 [Homo sapiens] less 72.2(n)    CD327544.1 
    zebrafish
    (Danio rerio)
    Actinopterygii apobec2a1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a less 63.58(n)
    61.46(a)
      503736  NM_001013314.1  NP_001013332.1 


    ENSEMBL Gene Tree for APOBEC2 (if available)
    TreeFam Gene Tree for APOBEC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOBEC2 gene
    APOBEC3G2  APOBEC3F2  APOBEC12  APOBEC3B2  APOBEC3D2  APOBEC3C2  APOBEC3A2  APOBEC3H2  
    AICDA2  
    10 SIMAP similar genes for APOBEC2 using alignment to 1 protein entry:     ABEC2_HUMAN:
    APOBEC3C    APOBEC3F    AID    AICDA    APOBEC3D    APOBEC3DE
    APOBEC3B    APOBEC3A    APOBEC3G    bK150C2.9

    APOBEC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/295 SNPs in APOBEC2 are shown (see all 295)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47144271,2
    C,F--41018980(+) ACTCCA/GTCTCA 1 -- us2k13Minor allele frequency- G:0.33NA 6
    rs1513310911,2
    --41019060(+) CAGCGA/GGACAC 1 -- us2k10--------
    rs1820273681,2
    --41019338(+) TTTCAA/GCCTAC 1 -- us2k10--------
    rs1405844711,2
    --41019353(+) GACCCC/TGACCC 1 -- us2k10--------
    rs777519311,2
    C,F--41019411(+) AAACAC/TGAAGA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1872007031,2
    C--41019485(+) TGTTCC/TGGCTC 1 -- us2k10--------
    rs1916177221,2
    --41019508(+) ATGGGC/TCCCCA 1 -- us2k10--------
    rs803189651,2
    C--41019537(+) AGTAGA/GCTTCT 1 -- us2k10--------
    rs1476673081,2
    --41019779(+) CAGAGC/TCTTTG 1 -- us2k10--------
    rs1816625661,2
    --41019912(+) AAGTAC/TGTAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for APOBEC2 (41020940 - 41032630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for APOBEC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526577CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing APOBEC2
    DNA2.0 Custom Variant and Variant Library Synthesis for APOBEC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604797    OMIM disorders: --

    3 diseases for APOBEC2:    About MalaCards
    tonsillitis    thyroiditis    hepatitis


    APOBEC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): APOBEC2
    Human Genome Epidemiology (HuGE) Navigator: APOBEC2 (1 document)

    Export disorders for APOBEC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOBEC2 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with APOBEC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. (PubMed id 10403781)1, 2, 3, 9 Liao W.... Chan L. (1999)
    2. The APOBEC-2 crystal structure and functional implications for the deaminase AID. (PubMed id 17187054)1, 2, 9 Prochnow C....Chen X.S. (2007)
    3. Gender differences in genetic risk profiles for cardiovascular disease. (PubMed id 18974842)1, 4 Silander K....Peltonen L. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing. (PubMed id 11698249)1, 9 Anant S....Davidson N.O. (2001)
    7. Excessive activity of apolipoprotein B mRNA editing en zyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenes is. (PubMed id 21469143)1 Okuyama S....Chiba T. (2012)
    8. Hydroxylation of 5-methylcytosine by TET1 promotes ac tive DNA demethylation in the adult brain. (PubMed id 21496894)2 Guo J.U....Song H. (2011)
    9. Microarray analysis of tonsils in immunoglobulin A ne phropathy patients. (PubMed id 20138841)1 Iio K....Rakugi H. (2010)
    10. APOBEC deaminases-mutases with defensive roles for im munity. (PubMed id 19911124)1 Prochnow C....Chen X.S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10930 HGNC: 605 AceView: APOBEC2 Ensembl:ENSG00000124701 euGenes: HUgn10930
    ECgene: APOBEC2 H-InvDB: APOBEC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOBEC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APOBEC2 gene:
    Search GeneIP for patents involving APOBEC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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