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APOBEC2 Gene

protein-coding   GIFtS: 56
GCID: GC06P041020

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like...
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Aliases
for APOBEC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 21 2     Probable C->U-Editing Enzyme APOBEC-22
ARCD12     EC 3.5.4.-3
ARP12     EC 3.5.48
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 22     

External Ids:    HGNC: 6051   Entrez Gene: 109302   Ensembl: ENSG000001247017   OMIM: 6047975   UniProtKB: Q9Y2353   

Export aliases for APOBEC2 gene to outside databases

Previous GC identifers: GC06P041023 GC06P041067 GC06P041128 GC06P040738


Summaries
for APOBEC2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for APOBEC2 Gene:
APOBEC2 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2) is a protein-coding gene. Diseases associated with APOBEC2 include tonsillitis, and thyroiditis. GO annotations related to this gene include cytidine deaminase activity and RNA binding. An important paralog of this gene is APOBEC3G.

UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
Function: Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display
detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic
regulation of gene expression through the process of active DNA demethylation

Gene Wiki entry for APOBEC2 Gene


Genomic Views
for APOBEC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOBEC2 gene promoter:
         AP-4   CUTL1   Roaz   GATA-1   AP-2beta   Pax-4a   NF-kappaB1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOBEC2 promoter sequence
   Search Chromatin IP Primers for APOBEC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOBEC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21

APOBEC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041020:  view genomic region     (about GC identifiers)

Start:
 41,020,940 bp from pter      End:
 41,032,630 bp from pter
Size:
 11,691 bases      Orientation:
 plus strand

Proteins
for APOBEC2 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235 (See protein sequence)
Recommended Name: Probable C->U-editing enzyme APOBEC-2  
Size: 224 amino acids; 25703 Da
Cofactor: Zinc (By similarity)
Subunit: Homotetramer
1 PDB 3D structure from and Proteopedia for APOBEC2:
2NYT (3D)    
Secondary accessions: B2R899 Q53F28 Q5TGU5 Q5TGU6

Explore the universe of human proteins at neXtProt for APOBEC2: NX_Q9Y235

Explore proteomics data for APOBEC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
    • 4 DME Specific Peptides for APOBEC2 (Q9Y235)
     GYLEDEHA  HAEEAFFN  LPPFEIVTG  VTWYVSSSPCAACADRI 


    See APOBEC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006780.1  
    ENSEMBL proteins: 
     ENSP00000244669  

    APOBEC2 Human Recombinant Protein Products:

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    Novus Biologicals APOBEC2 Proteins
    Novus Biologicals APOBEC2 Lysates
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    APOBEC2 Antibody Products:

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    Abcam antibodies for APOBEC2
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    LSBio Antibodies in human, mouse, rat for APOBEC2

    APOBEC2 Assay Products:

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    Cloud-Clone Corp. ELISAs for APOBEC2
    Cloud-Clone Corp. CLIAs for APOBEC2

    Domains /
    Families
    for APOBEC2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    APOBEC: Apolipoprotein B mRNA editing enzymes

    3 InterPro protein domains:
     IPR007904 APOBEC_C
     IPR013158 APOBEC_N
     IPR016193 Cytidine_deaminase-like

    Graphical View of Domain Structure for InterPro Entry Q9Y235

    ProtoNet protein and cluster: Q9Y235

    2 Blocks protein domains:
    IPB002125 Cytidine/deoxycytidylate deaminase
    IPB007904 APOBEC-like


    UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family


    APOBEC2 for domains           About GeneDecksing


    Function
    for APOBEC2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABEC2_HUMAN, Q9Y235
    Function: Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display
    detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic
    regulation of gene expression through the process of active DNA demethylation

         Genatlas biochemistry entry for APOBEC2:
    apolipoprotein B,mRNA editing enzyme,catalytic polypeptide 2,expressed exclusively in heart and skeletal muscle

         Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS10403781
    GO:0003824catalytic activity ----
    GO:0004126cytidine deaminase activity TAS10403781
    GO:0008270zinc ion binding IEA--
    GO:0016814hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines ----
         
    APOBEC2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for APOBEC2:
     Decreased Wnt reporter activit  Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Apobec2):
     growth/size/body  normal  skeleton 

    APOBEC2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Apobec2tm1Msn for APOBEC2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOBEC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APOBEC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOBEC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOBEC2

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat APOBEC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APOBEC2 (see all 11):
    hsa-miR-30c-2* hsa-miR-409-3p hsa-miR-4267 hsa-miR-4316 hsa-miR-214 hsa-miR-885-3p hsa-miR-593 hsa-miR-30c-1*
    SwitchGear 3'UTR luciferase reporter plasmid: APOBEC2 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for APOBEC2
    Predesigned siRNA for gene silencing in human, mouse, rat APOBEC2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for APOBEC2

    Clone
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    OriGene ORF clones in mouse, rat for APOBEC2
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    GenScript: all cDNA clones in your preferred vector: APOBEC2 (NM_006789)
    Sino Biological Human cDNA Clone for APOBEC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOBEC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for APOBEC2 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC2


    Localization
    for APOBEC2 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Pathways & Interactions
    for APOBEC2 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APOBEC2
    Interactions:

        Search GeneGlobe Interaction Network for APOBEC2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for APOBEC2 (Q9Y2353 ENSP000002446694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBEC1P412383, ENSP000002293044I2D: score=2 STRING: ENSP00000229304
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0009972cytidine deamination TAS10403781
    GO:0016556mRNA modification IEA--
    GO:0080111DNA demethylation IDA--

    APOBEC2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for APOBEC2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOBEC2 (ABEC2)

    3 Novoseek inferred chemical compound relationships for APOBEC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 86.6 10 11698249 (3), 10403781 (2), 16720547 (1), 16055735 (1) (see all 6)
    retinoic acid 22.1 1 8119938 (1)
    steroid 5.65 3 1639815 (2), 8505324 (1)



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    Transcripts
    for APOBEC2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for APOBEC2 gene: 
    NM_006789.3  

    Unigene Cluster for APOBEC2:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
    Hs.555915  [show with all ESTs]
    Unigene Representative Sequence: NM_006789
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244669(uc003opl.3 uc010jxf.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat APOBEC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APOBEC2 (see all 11):
    hsa-miR-30c-2* hsa-miR-409-3p hsa-miR-4267 hsa-miR-4316 hsa-miR-214 hsa-miR-885-3p hsa-miR-593 hsa-miR-30c-1*
    SwitchGear 3'UTR luciferase reporter plasmid: APOBEC2 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for APOBEC2
    Predesigned siRNA for gene silencing in human, mouse, rat APOBEC2
    Clone
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    OriGene ORF clones in mouse, rat for APOBEC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: APOBEC2 (NM_006789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOBEC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC2
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for APOBEC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APOBEC2
      QuantiTect SYBR Green Assays in human, mouse, rat APOBEC2
      QuantiFast Probe-based Assays in human, mouse, rat APOBEC2

    Additional mRNA sequence: 

    AF086496.1 AF161698.1 AK223461.1 AK300689.1 AK308197.1 AK310006.1 AK313288.1 BC047767.2 
    BC069688.1 BC069764.1 

    3 DOTS entries:

    DT.440666  DT.92422005  DT.95366225 

    Selected AceView cDNA sequences (see all 74):

    N91784 CA942892 AI126842 NM_006789 BF204767 F35775 AI204314 BM724377 
    AI694918 BC069764 BF223030 BC069688 AI141858 F27745 CA942652 AF086496 
    W93864 AI457949 F24691 CB051273 N93239 AA775531 W58285 BF205273 

    GeneLoc Exon Structure


    Expression
    for APOBEC2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOBEC2 expression in normal human tissues (normalized intensities)      APOBEC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCCAGTC
    APOBEC2 Expression
    About this image


    APOBEC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Cardiomyocyte-like progenitor cells
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    APOBEC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    APOBEC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555915

    UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
    Tissue specificity: Expressed exclusively in heart and skeletal muscle

        Custom PCR Arrays for APOBEC2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC2

    Orthologs
    for APOBEC2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for APOBEC2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Apobec21 , 5 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 less1, 5 87.95(n)1
    90.62(a)1    		   17 (24.02 cM)5
    118111  NM_009694.31  NP_033824.11 
     484192315 
    chicken
    (Gallus gallus)    		 Aves APOBEC21 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 less 73.56(n)
    79.33(a)    		   419915  XM_418038.3  XP_418038.1 
    lizard
    (Anolis carolinensis)    		 Reptilia APOBEC26
    		 apolipoprotein B mRNA editing enzyme, catalytic po...
    		 66(a)
    		 1 ↔ 1
    		 4(123361945-123363469)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.58762 Xenopus laevis transcribed sequence with weak similarity to protein refNP_006780.1 (H.sapiens) apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 [Homo sapiens] less 72.2(n)    CD327544.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii apobec2a1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a less 64.18(n)
    62.19(a)    		   503736  NM_001013314.2  NP_001013332.1 


    ENSEMBL Gene Tree for APOBEC2 (if available)
    TreeFam Gene Tree for APOBEC2 (if available)

    Paralogs
    for APOBEC2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APOBEC2 gene
    APOBEC3G2  APOBEC3F2  APOBEC12  APOBEC3B2  APOBEC3D2  APOBEC3C2  APOBEC3A2  APOBEC3H2  
    AICDA2  
    10 SIMAP similar genes for APOBEC2 using alignment to 1 protein entry:     ABEC2_HUMAN:
    APOBEC3C    APOBEC3F    AID    AICDA    APOBEC3D    APOBEC3DE
    APOBEC3B    APOBEC3A    APOBEC3G    bK150C2.9

    APOBEC2 for paralogs           About GeneDecksing



    Genomic Variants
    for APOBEC2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APOBEC2 (see all 295)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs47144271,2
    		C,F--41018980(+) ACTCCA/GTCTCA 1 -- us2k13Minor allele frequency- G:0.33NA 6
    rs1513310911,2
    		--41019060(+) CAGCGA/GGACAC 1 -- us2k10--------
    rs1820273681,2
    		--41019338(+) TTTCAA/GCCTAC 1 -- us2k10--------
    rs1405844711,2
    		--41019353(+) GACCCC/TGACCC 1 -- us2k10--------
    rs777519311,2
    		C,F--41019411(+) AAACAC/TGAAGA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1872007031,2
    		C--41019485(+) TGTTCC/TGGCTC 1 -- us2k10--------
    rs1916177221,2
    		--41019508(+) ATGGGC/TCCCCA 1 -- us2k10--------
    rs803189651,2
    		C--41019537(+) AGTAGA/GCTTCT 1 -- us2k10--------
    rs1476673081,2
    		--41019779(+) CAGAGC/TCTTTG 1 -- us2k10--------
    rs1816625661,2
    		--41019912(+) AAGTAC/TGTAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for APOBEC2 (41020940 - 41032630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for APOBEC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526577CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOBEC2
    DNA2.0 Custom Variant and Variant Library Synthesis for APOBEC2

    Disorders / Diseases
    for APOBEC2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TryGeneCards Plus    		 OMIM gene information: 604797    OMIM disorders: --

    4 diseases for APOBEC2:    About MalaCards
    tonsillitis    thyroiditis    hiv-1    hepatitis


    APOBEC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): APOBEC2
    Human Genome Epidemiology (HuGE) Navigator: APOBEC2 (1 document)

    Export disorders for APOBEC2 gene to outside databases

    Publications
    for APOBEC2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOBEC2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with APOBEC2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. (PubMed id 10403781)1, 2, 3, 9 Liao W.... Chan L. (Biochem. Biophys. Res. Commun. 1999)
    2. The APOBEC-2 crystal structure and functional implications for the deaminase AID. (PubMed id 17187054)1, 2, 9 Prochnow C.... Chen X.S. (Nature 2007)
    3. Gender differences in genetic risk profiles for cardiovascular disease. (PubMed id 18974842)1, 4 Silander K....Peltonen L. (PLoS ONE 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing. (PubMed id 11698249)1, 9 Anant S....Davidson N.O. (Am. J. Physiol., Cell Physiol. 2001)
    7. Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis. (PubMed id 21469143)1 Okuyama S....Chiba T. (Int. J. Cancer 2012)
    8. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. (PubMed id 21496894)2 Guo J.U.... Song H. (Cell 2011)
    9. Microarray analysis of tonsils in immunoglobulin A nephropathy patients. (PubMed id 20138841)1 Iio K....Rakugi H. (Biochem. Biophys. Res. Commun. 2010)
    10. APOBEC deaminases-mutases with defensive roles for immunity. (PubMed id 19911124)1 Prochnow C....Chen X.S. (Sci. China, C, Life Sci. 2009)

    External Searches for APOBEC2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing APOBEC2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10930 HGNC: 605 AceView: APOBEC2 Ensembl:ENSG00000124701 euGenes: HUgn10930
    ECgene: APOBEC2 H-InvDB: APOBEC2

    Other Databases showing APOBEC2 gene

    (According to HUGE)
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    TryGeneCards Plus    		   --

    Specialized Databases showing APOBEC2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APOBEC2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for APOBEC2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    TryGeneCards Plus    		Patent Information for APOBEC2 gene:
    Search GeneIP for patents involving APOBEC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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