Aliases for APOBEC2 Gene
Aliases for APOBEC2 Gene
- Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 2 2 3 5
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 2 2 3
- MRNA(Cytosine(6666)) Deaminase 2 3 4
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 2 3
- Probable C->U-Editing Enzyme APOBEC-2 3
- C->U-Editing Enzyme APOBEC-2 3
External Ids for APOBEC2 Gene
- HGNC: 605
- Entrez Gene: 10930
- Ensembl: ENSG00000124701
- OMIM: 604797
- UniProtKB: Q9Y235
Previous GeneCards Identifiers for APOBEC2 Gene
- GC06P041023
- GC06P041067
- GC06P041128
- GC06P041020
- GC06P040738
Summaries for APOBEC2 Gene
GeneCards Summary for APOBEC2 Gene
APOBEC2 (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Formation of the Editosome. Gene Ontology (GO) annotations related to this gene include RNA binding and cytidine deaminase activity. An important paralog of this gene is APOBEC3F.
UniProtKB/Swiss-Prot for APOBEC2 Gene
-
Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Additional gene information for APOBEC2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC2 Gene
Genomics for APOBEC2 Gene
GeneHancer (GH) Regulatory Elements for APOBEC2 Gene
- Top Transcription factor binding sites by QIAGEN in the APOBEC2 gene promoter:
Regulatory Element Products
Genomic Locations for APOBEC2 Gene
- chr6:41,053,201-41,064,891
- (GRCh38/hg38)
- Size:
- 11,691 bases
- Orientation:
- Plus strand
- chr6:41,020,940-41,032,630
- (GRCh37/hg19)
Genomic View for APOBEC2 Gene
- Cytogenetic band:
-
- 6p21.1 by Ensembl
- 6p21.1 by Entrez Gene
- 6p21.1 by HGNC


RefSeq DNA sequence for APOBEC2 Gene
Proteins for APOBEC2 Gene
-
Protein details for APOBEC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y235-ABEC2_HUMAN
- Recommended name:
- C->U-editing enzyme APOBEC-2
- Protein Accession:
- Q9Y235
- B2R899
- Q53F28
- Q5TGU5
- Q5TGU6
Protein attributes for APOBEC2 Gene
- Size:
- 224 amino acids
- Molecular mass:
- 25703 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homotetramer.
Protein Expression for APOBEC2 Gene
Selected DME Specific Peptides for APOBEC2 Gene
- Q9Y235:
-
- VTWYVSSSPCAACADRI
- LPPFEIVTG
- GYLEDEHA
- HAEEAFFN
Post-translational modifications for APOBEC2 Gene
Other Protein References for APOBEC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for APOBEC2
-
Abcam antibodies for APOBEC2
- Invitrogen Antibodies for APOBEC2
- GeneTex APOBEC2 antibody for APOBEC2
-
Santa Cruz Biotechnology (SCBT) Antibodies for APOBEC2
- Sino Biological Antibodies for APOBEC2
Protein Products
-
OriGene Purified Proteins for APOBEC2
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Assay Products
Domains & Families for APOBEC2 Gene
Gene Families for APOBEC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for APOBEC2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for APOBEC2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y235- Family:
-
- Belongs to the cytidine and deoxycytidylate deaminase family.
Function for APOBEC2 Gene
Molecular function for APOBEC2 Gene
- GENATLAS Biochemistry:
- apolipoprotein B,mRNA editing enzyme,catalytic polypeptide 2,expressed exclusively in heart and skeletal muscle
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cytosine(6666) in apolipoprotein B mRNA + H(2)O = uracil(6666) in apolipoprotein B mRNA + NH(3).
- UniProtKB/Swiss-Prot Function:
- Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Enzyme Numbers (IUBMB) for APOBEC2 Gene
Phenotypes From GWAS Catalog for APOBEC2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | TAS | 10403781 |
GO:0003824 | catalytic activity | IEA | -- |
GO:0004126 | cytidine deaminase activity | IEA,IDA | 10403781 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for APOBEC2 Gene
- MGI mutant phenotypes for APOBEC2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for APOBEC2:
Animal Models for APOBEC2 Gene
- MGI Knock Outs for APOBEC2:
-
- Apobec2 tm1Msn
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for APOBEC2 gene
-
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- Search ViGene Biosciences for APOBEC2
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC2
- genomics-online: gRNA clones - Search results for 116 available APOBEC2 gene related products
- Overview of 116 available APOBEC2 gene related products
- Applied Biological Materials CRISPR for APOBEC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
- Search ViGene Biosciences for APOBEC2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for APOBEC2
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- Overview of 116 available APOBEC2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for APOBEC2 gene
Clone Products
- Sino Biological Human cDNA Clone for APOBEC2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for APOBEC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for APOBEC2
-
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-
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-
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No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for APOBEC2 Gene
Localization for APOBEC2 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for APOBEC2 Gene
Pathways & Interactions for APOBEC2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Formation of the Editosome |
.82
|
|
2 | Gene Expression |
.48
|
Pathways by source for APOBEC2 Gene
4 Reactome pathways for APOBEC2 Gene
Interacting Proteins for APOBEC2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006397 | mRNA processing | IEA | -- |
GO:0009972 | cytidine deamination | IEA | -- |
GO:0016554 | cytidine to uridine editing | IEA,IDA | 10403781 |
GO:0016556 | mRNA modification | IEA | -- |
GO:0080111 | DNA demethylation | IDA | 21496894 |
No data available for SIGNOR curated interactions for APOBEC2 Gene
Transcripts for APOBEC2 Gene
mRNA/cDNA for APOBEC2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (74) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for APOBEC2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC2
- genomics-online: gRNA clones - Search results for 116 available APOBEC2 gene related products
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- Applied Biological Materials CRISPR for APOBEC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC2
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miRNA Products
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Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for APOBEC2
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- VectorBuilder custom plasmid, inducible vectors for APOBEC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for APOBEC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for APOBEC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Cushion Mesenchymal Cells Endocardium
- Cardiac Crescent Cells Cardiac Crescent
- Cardiomyocyte-like progenitor cells(Uosaki H et. al. 2011)
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
- Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for APOBEC2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOBEC2 Gene
NURSA nuclear receptor signaling pathways regulating expression of APOBEC2 Gene:
APOBEC2SOURCE GeneReport for Unigene cluster for APOBEC2 Gene:
Hs.555915mRNA Expression by UniProt/SwissProt for APOBEC2 Gene:
Q9Y235-ABEC2_HUMANEvidence on tissue expression from TISSUES for APOBEC2 Gene
- Muscle(4.7)
- Heart(4.5)
- Pancreas(4.3)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for APOBEC2
- genomics-online: primer clones - Search results for 116 available APOBEC2 gene related products
- Overview of 116 available APOBEC2 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APOBEC2 Gene
Orthologs for APOBEC2 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | APOBEC2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | APOBEC2 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | APOBEC2 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Apobec2 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Apobec2 33 |
|
||
cow (Bos Taurus) |
Mammalia | APOBEC2 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | APOBEC2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | APOBEC2 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | APOBEC2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | apobec2 33 |
|
||
Str.11906 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.5876 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | apobec2a 33 34 |
|
||
APOBEC2 (2 of 2) 34 |
|
OneToMany | |||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2129 33 |
|
- Species where no ortholog for APOBEC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for APOBEC2 Gene
Paralogs for APOBEC2 Gene
(10) SIMAP similar genes for APOBEC2 Gene using alignment to 1 proteins:
Variants for APOBEC2 Gene
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000009656 | -- | 41,054,566(+) | CC/C | intron_variant | |
rs1000191526 | -- | 41,064,989(+) | C/T | downstream_transcript_variant | |
rs1000415994 | -- | 41,057,594(+) | A/C | intron_variant | |
rs1000463531 | -- | 41,057,960(+) | G/A | intron_variant | |
rs1000597301 | -- | 41,064,361(+) | G/T | 3_prime_UTR_variant |
Additional Variant Information for APOBEC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- APOBEC2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC2 Gene
Disorders for APOBEC2 Gene
Additional Disease Information for APOBEC2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for APOBEC2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC2 Gene
Publications for APOBEC2 Gene
- APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. (PMID: 10403781) Liao W … Chan L (Biochemical and biophysical research communications 1999) 2 3 4 22 58
- The APOBEC-2 crystal structure and functional implications for the deaminase AID. (PMID: 17187054) Prochnow C … Chen XS (Nature 2007) 3 4 22 58
- Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. (PMID: 21496894) Guo JU … Song H (Cell 2011) 3 4 58
- Gender differences in genetic risk profiles for cardiovascular disease. (PMID: 18974842) Silander K … Peltonen L (PloS one 2008) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for APOBEC2 Gene
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- Invitrogen Antibodies for APOBEC2
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- VectorBuilder custom plasmid, inducible vectors for APOBEC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOBEC2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 95 available APOBEC2 Antibodies ranked by validation data
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- antibodies-online: Search results for available APOBEC2 related products ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for APOBEC2 gene
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- Overview of 116 available APOBEC2 gene related products
Sources for APOBEC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
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