Aliases for APOBEC2 Gene
Aliases for APOBEC2 Gene
- Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 2 2 3
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 2 2 3 5
- MRNA(Cytosine(6666)) Deaminase 2 3 4
- Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide Like 2 3
- Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 2 3
- Probable C->U-Editing Enzyme APOBEC-2 3
External Ids for APOBEC2 Gene
- HGNC: 605
- Entrez Gene: 10930
- Ensembl: ENSG00000124701
- OMIM: 604797
- UniProtKB: Q9Y235
Previous GeneCards Identifiers for APOBEC2 Gene
- GC06P041023
- GC06P041067
- GC06P041128
- GC06P040738
Summaries for APOBEC2 Gene
GeneCards Summary for APOBEC2 Gene
APOBEC2 (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and cytidine deaminase activity. An important paralog of this gene is AICDA.
UniProtKB/Swiss-Prot for APOBEC2 Gene
-
Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC2 Gene
Genomics for APOBEC2 Gene
Regulatory Elements for APOBEC2 Gene
Enhancers for APOBEC2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around APOBEC2 on UCSC Golden Path with GeneCards custom track
Promoters for APOBEC2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around APOBEC2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the APOBEC2 gene promoter:
Regulatory Element Products
Genomic Location for APOBEC2 Gene
- Chromosome:
- 6
- Start:
- 41,053,201 bp from pter
- End:
- 41,064,891 bp from pter
- Size:
- 11,691 bases
- Orientation:
- Plus strand
Genomic View for APOBEC2 Gene
Genes around APOBEC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.1 by Ensembl
- 6p21 by Entrez Gene
- 6p21 by HGNC
APOBEC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOBEC2 Gene
Proteins for APOBEC2 Gene
-
Protein details for APOBEC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y235-ABEC2_HUMAN
- Recommended name:
- C->U-editing enzyme APOBEC-2
- Protein Accession:
- Q9Y235
- B2R899
- Q53F28
- Q5TGU5
- Q5TGU6
Protein attributes for APOBEC2 Gene
- Size:
- 224 amino acids
- Molecular mass:
- 25703 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homotetramer.
Protein Expression for APOBEC2 Gene
Selected DME Specific Peptides for APOBEC2 Gene
Post-translational modifications for APOBEC2 Gene
Other Protein References for APOBEC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for APOBEC2
- Invitrogen Antibodies for APOBEC2
- antibodies-online Antibodies for APOBEC2: See all 84
- GeneTex APOBEC2 antibody for APOBEC2
-
Santa Cruz Biotechnology (SCBT) Antibodies for APOBEC2
Protein Products
-
OriGene Purified Proteins for APOBEC2
- Search Origene for MassSpec and Protein Over-expression Lysates for APOBEC2
- Origene Custom Protein Services for APOBEC2
- antibodies-online Proteins for APOBEC2: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for APOBEC2
Assay Products
Domains & Families for APOBEC2 Gene
Gene Families for APOBEC2 Gene
Protein Domains for APOBEC2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for APOBEC2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y235UniProtKB/Swiss-Prot:
ABEC2_HUMAN :- Contains 1 CMP/dCMP-type deaminase domain.
- Belongs to the cytidine and deoxycytidylate deaminase family.
- Domain:
-
- Contains 1 CMP/dCMP-type deaminase domain.
- Family:
-
- Belongs to the cytidine and deoxycytidylate deaminase family.
Function for APOBEC2 Gene
Molecular function for APOBEC2 Gene
- GENATLAS Biochemistry:
- apolipoprotein B,mRNA editing enzyme,catalytic polypeptide 2,expressed exclusively in heart and skeletal muscle
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cytosine(6666) in apolipoprotein B mRNA + H(2)O = uracil(6666) in apolipoprotein B mRNA + NH(3).
- UniProtKB/Swiss-Prot Function:
- Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Enzyme Numbers (IUBMB) for APOBEC2 Gene
- EC 3.5.4 63
- EC 3.5.4.36 4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | IEA | -- |
Phenotypes for APOBEC2 Gene
- MGI mutant phenotypes for APOBEC2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for APOBEC2:
Animal Models for APOBEC2 Gene
- MGI Knock Outs for APOBEC2:
-
- Apobec2 tm1Msn
Animal Model Products
-
Taconic Biosciences Mouse Models for APOBEC2
-
ViGene Biosciences lentiviral particle packaged cDNA for APOBEC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOBEC2 gene
- Search ViGene Biosciences for APOBEC2
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC2
- GenScript: Design CRISPR guide RNA sequences for APOBEC2
miRNA Products
- Search ViGene Biosciences for APOBEC2
Clone Products
- OriGene clones in human for APOBEC2
- OriGene ORF clones in human,mouse,rat for APOBEC2
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- Sino Biological Human cDNA Clone for APOBEC2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for APOBEC2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for APOBEC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOBEC2 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for APOBEC2 Gene
Localization for APOBEC2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| extracellular | 1 |
| peroxisome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for APOBEC2 Gene
Pathways & Interactions for APOBEC2 Gene
More details on SuperPathways for APOBEC2
No Data Available
Interacting Proteins for APOBEC2 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| APOBEC1 |
No data available for Pathways by source and SIGNOR curated interactions for APOBEC2 Gene
Transcripts for APOBEC2 Gene
mRNA/cDNA for APOBEC2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (74) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for APOBEC2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for APOBEC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC2
- GenScript: Design CRISPR guide RNA sequences for APOBEC2
miRNA Products
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Clone Products
- OriGene clones in human for APOBEC2
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- Sino Biological Human cDNA Clone for APOBEC2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for APOBEC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Cushion Mesenchymal Cells Endocardium
- Cardiac Crescent Cells Cardiac Crescent
- Cardiomyocyte-like progenitor cells(Uosaki H et. al. 2011)
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
- Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for APOBEC2 Gene
This gene is overexpressed in Muscle - Skeletal (x26.9), Heart - Left Ventricle (x17.0), and Heart - Atrial Appendage (x5.4).
This gene is overexpressed in Esophagus (22.3), Fetal heart (19.4), Heart (12.1), and Tonsil (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOBEC2 Gene
SOURCE GeneReport for Unigene cluster for APOBEC2 Gene Hs.555915
mRNA Expression by UniProt/SwissProt for APOBEC2 Gene
Q9Y235-ABEC2_HUMAN
Tissue specificity:
Expressed exclusively in heart and skeletal muscle.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for APOBEC2
Orthologs for APOBEC2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | APOBEC2 35 |
|
||
| APOBEC2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | APOBEC2 35 |
|
||
| APOBEC2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Apobec2 35 |
|
||
| Apobec2 16 |
|
||||
| Apobec2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | APOBEC2 35 |
|
||
| APOBEC2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Apobec2 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | APOBEC2 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | APOBEC2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | APOBEC2 35 |
|
||
| APOBEC2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | APOBEC2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | apobec2 35 |
|
||
| Str.11906 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5876 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | apobec2a 35 |
|
||
| APOBEC2 (2 of 2) 36 |
|
OneToMany | |||
| apobec2a 36 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2129 35 |
|
- Species with no ortholog for APOBEC2:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for APOBEC2 Gene
Paralogs for APOBEC2 Gene
(10) SIMAP similar genes for APOBEC2 Gene using alignment to 1 proteins:
Variants for APOBEC2 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2076472 | - | 41,061,603(+) | CATTA(C/T)CAAAA | reference, missense | |
| rs1014737 | -- | 41,054,978(+) | AAGGG(A/T)TAAGT | intron-variant | |
| rs1065197 | -- | 41,061,749(+) | ACTTC(A/G)AATAT | reference, missense | |
| rs6919961 | -- | 41,052,622(+) | TGAGC(A/T)AAGTA | upstream-variant-2KB | |
| rs2057001 | -- | 41,055,208(+) | CTGGT(C/T)TCTTA | intron-variant |
Residual Variation Intolerance Score:
56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.60;
78.11% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for APOBEC2 Gene
Disorders for APOBEC2 Gene
Relevant External Links for APOBEC2
No disorders were found for APOBEC2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC2 Gene
Publications for APOBEC2 Gene
- APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. (PMID: 10403781) Liao W. … Chan L. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
- The APOBEC-2 crystal structure and functional implications for the deaminase AID. (PMID: 17187054) Prochnow C. … Chen X.S. (Nature 2007) 3 23
- ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing. (PMID: 11698249) Anant S. … Davidson N.O. (Am. J. Physiol., Cell Physiol. 2001) 3 23
- Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis. (PMID: 21469143) Okuyama S. … Chiba T. (Int. J. Cancer 2012) 3
- Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. (PMID: 21496894) Guo J.U. … Song H. (Cell 2011) 3
Products for APOBEC2 Gene
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- OriGene Purified Proteins for APOBEC2
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- OriGene qPCR primer pairs for APOBEC2
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- Novus Biologicals
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- Taconic Biosciences Mouse Models for APOBEC2
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- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for APOBEC2: See all 84
- Search antibodies-online for kits
- antibodies-online Proteins for APOBEC2: See all 8
- Search antibodies-online for peptides
- GeneTex APOBEC2 antibody for APOBEC2
- Search GeneTex for Proteins for APOBEC2
- ViGene Biosciences adenoviral particle packaged cDNA for APOBEC2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for APOBEC2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for APOBEC2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for APOBEC2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for APOBEC2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for APOBEC2 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for APOBEC2
- Search Santa Cruz Biotechnology (SCBT) for APOBEC2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for APOBEC2
Sources for APOBEC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
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- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
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- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
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- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
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- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
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- (110) ApexBio
- (111) Addgene
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- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
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- (119) GeneReviews
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- (149) ENCODE
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