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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOBEC2 Gene

protein-coding   GIFtS: 55
GCID: GC06P041020

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like...
 Explore 4 diseases affiliated with
APOBEC2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for APOBEC2    

Aliases
for APOBEC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 21 2     Probable C->U-Editing Enzyme APOBEC-22
ARCD11 2     EC 3.5.4.-3
ARP11 2     EC 3.5.48
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 22     

External Ids:    HGNC: 6051   Entrez Gene: 109302   Ensembl: ENSG000001247017   OMIM: 6047975   UniProtKB: Q9Y2353   

Export aliases for APOBEC2 gene to outside databases

Previous GC identifers: GC06P041023 GC06P041067 GC06P041128 GC06P040738


Summaries
for APOBEC2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
Function: Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable
apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of
gene expression through the process of active DNA demethylation

Gene Wiki entry for APOBEC2


Genomic Views
for APOBEC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOBEC2 gene promoter:
         AP-4   CUTL1   Roaz   GATA-1   AP-2beta   Pax-4a   NF-kappaB1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOBEC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for APOBEC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21

APOBEC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041020:  view genomic region     (about GC identifiers)

Start:
 41,020,940 bp from pter      End:
 41,032,630 bp from pter
Size:
 11,691 bases      Orientation:
 plus strand

Proteins
for APOBEC2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235 (See protein sequence)
Recommended Name: Probable C->U-editing enzyme APOBEC-2  
Size: 224 amino acids; 25703 Da
Cofactor: Zinc (By similarity)
Subunit: Homotetramer
1 PDB 3D structure from and Proteopedia for APOBEC2:
2NYT (3D)    
Secondary accessions: B2R899 Q53F28 Q5TGU5 Q5TGU6

Explore the universe of human proteins at neXtProt for APOBEC2: NX_Q9Y235

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y235

    • 4 DME Specific Peptides for APOBEC2 (Q9Y235)
     GYLEDEHA  HAEEAFFN  LPPFEIVTG  VTWYVSSSPCAACADRI 

    APOBEC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006780.1  
    ENSEMBL proteins: 
     ENSP00000244669  

    Human Recombinant Protein Products: 
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    Uscn Proteins for APOBEC2


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    Uscn ELISAs and CLIAs for APOBEC2

    Protein Domains /
    Families
    for APOBEC2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    APOBEC2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016193 Cytidine_deaminase-like
     IPR007904 APOBEC_C
     IPR013158 APOBEC_N

    Graphical View of Domain Structure for InterPro Entry Q9Y235

    ProtoNet protein and cluster: Q9Y235

    2 Blocks protein families:
    IPB002125 Cytidine/deoxycytidylate deaminase
    IPB007904 APOBEC-like


    UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family


    Function
    for APOBEC2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
    Function: Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable
    apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of
    gene expression through the process of active DNA demethylation

         Genatlas biochemistry entry for APOBEC2:
    apolipoprotein B,mRNA editing enzyme,catalytic polypeptide 2,expressed exclusively in heart and skeletal muscle

    Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOBEC2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate APOBEC2 (see all 11):
    hsa-miR-30c-2* hsa-miR-409-3p hsa-miR-4267 hsa-miR-4316 hsa-miR-214 hsa-miR-885-3p hsa-miR-593 hsa-miR-30c-1*
    SwitchGear 3'UTR luciferase reporter plasmid: APOBEC2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOBEC2 (see all 7)
    OriGene shRNA RFP: APOBEC2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOBEC2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for APOBEC2

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for APOBEC2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS10403781
    GO:0004126cytidine deaminase activity TAS10403781
    GO:0008270zinc ion binding IEA--


    APOBEC2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for APOBEC2:
     Decreased Wnt reporter activit  Decreased viability of wild-ty 

    Animal Models:
         Mouse knock-out Apobec2tm1Msn for APOBEC2
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Apobec2):
     growth/size  normal  skeleton 

    APOBEC2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for APOBEC2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOBEC2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for APOBEC2 (Q9Y2353 ENSP000002446694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBEC1P412383, ENSP000002293044I2D: score=2 STRING: ENSP00000229304
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0009972cytidine deamination TAS10403781
    GO:0016556mRNA modification IEA--
    GO:0080111DNA demethylation IDA--


    APOBEC2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for APOBEC2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOBEC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOBEC2
    3 Novoseek chemical compound relationships for APOBEC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 86.6 10 11698249 (3), 10403781 (2), 16720547 (1), 16055735 (1) (see all 6)
    retinoic acid 22.1 1 8119938 (1)
    steroid 5.65 3 1639815 (2), 8505324 (1)

    Search CenterWatch for drugs/clinical trials and news about APOBEC2 / ABEC2 

    Transcripts
    for APOBEC2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APOBEC2 gene: 
    NM_006789.3  

    Unigene Cluster for APOBEC2:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
    Hs.555915  [show with all ESTs]
    Unigene Representative Sequence: NM_006789
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244669(uc003opl.3 uc010jxf.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOBEC2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate APOBEC2 (see all 11):
    hsa-miR-30c-2* hsa-miR-409-3p hsa-miR-4267 hsa-miR-4316 hsa-miR-214 hsa-miR-885-3p hsa-miR-593 hsa-miR-30c-1*
    SwitchGear 3'UTR luciferase reporter plasmid: APOBEC2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOBEC2 (see all 7)
    OriGene shRNA RFP: APOBEC2
    OriGene siRNA: APOBEC2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOBEC2
    Clone
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    GenScript: all cDNA clones in your preferred vector: APOBEC2 (NM_006789)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOBEC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APOBEC2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOBEC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOBEC2

    Additional cDNA sequence: 

    AF086496.1 AF161698.1 AK223461.1 AK300689.1 AK308197.1 AK310006.1 AK313288.1 BC047767.2 
    BC069688.1 BC069764.1 

    3 DOTS entries:

    DT.440666  DT.92422005  DT.95366225 

    24/74 AceView cDNA sequences (see all 74):

    BC069688 NM_006789 F35775 BC069764 N91784 AI126842 F27745 CA942892 
    BF204767 AI694918 BM724377 AI141858 BF223030 AI204314 F24116 AI383691 
    AI097157 BC047767 AI911727 AI695997 AW044334 BF205273 AA708834 W93864 

    GeneLoc Exon Structure


    Expression
    for APOBEC2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOBEC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTCCAGTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    APOBEC2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    HeartPrimitive Heart TubePrimitive Heart Tube CellsMyocardium
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Cardiomyocyte-like progenitor cells (Derivation of cardio...)

    See APOBEC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOBEC2

    SOURCE GeneReport for Unigene cluster: Hs.555915

    UniProtKB/Swiss-Prot: ABEC2_HUMAN, Q9Y235
    Tissue specificity: Expressed exclusively in heart and skeletal muscle

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    In Situ
    Assay Products:     
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    Orthologs
    for APOBEC2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for APOBEC2 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves APOBEC21 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 less 73.58(n)
    78.8(a)    		   419915  XM_418038.2  XP_418038.1 
    lizard
    (Anolis carolinensis)    		 Reptilia APOBEC26
    		 --
    		 74(a)
    		 1 ↔ 1
    		 4(123361945-123363469)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.58762 Xenopus laevis transcribed sequence with weak similarity to protein refNP_006780.1 (H.sapiens) apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 [Homo sapiens] less 72.2(n)    CD327544.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii apobec2a1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a less 63.58(n)
    61.46(a)    		   503736  NM_001013314.1  NP_001013332.1 


    ENSEMBL Gene Tree for APOBEC2 (if available)
    TreeFam Gene Tree for APOBEC2 (if available) 

    Paralogs
    for APOBEC2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOBEC2 gene
    APOBEC3G2  APOBEC3D2  APOBEC3F2  APOBEC12  APOBEC3B2  APOBEC3C2  APOBEC3A2  AICDA2  
    APOBEC3H2  
    10 SIMAP similar genes for APOBEC2 using alignment to 1 protein entry:     ABEC2_HUMAN:
    APOBEC3C    APOBEC3F    AID    AICDA    APOBEC3D    APOBEC3DE
    APOBEC3B    APOBEC3A    APOBEC3G    bK150C2.9

    APOBEC2 for paralogs           About GeneDecksing



    Genomic Variants
    for APOBEC2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/240 NCBI SNPs in APOBEC2 are shown (see all 240)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs47144271,2
    		C,F,--41018980(+) ACTCCA/GTCTCA 1 -- us2k13Minor allele frequency- G:0.33NA 6
    rs1513310911,2
    		--41019060(+) CAGCGA/GGACAC 1 -- us2k10--------
    rs1820273681,2
    		--41019338(+) TTTCAA/GCCTAC 1 -- us2k10--------
    rs1405844711,2
    		--41019353(+) GACCCC/TGACCC 1 -- us2k10--------
    rs777519311,2
    		C,F,--41019411(+) AAACAC/TGAAGA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1872007031,2
    		--41019485(+) TGTTCC/TGGCTC 1 -- us2k10--------
    rs1916177221,2
    		--41019508(+) ATGGGC/TCCCCA 1 -- us2k10--------
    rs803189651,2
    		--41019537(+) AGTAGA/GCTTCT 1 -- us2k10--------
    rs1476673081,2
    		--41019779(+) CAGAGC/TCTTTG 1 -- us2k10--------
    rs1816625661,2
    		--41019912(+) AAGTAC/TGTAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for APOBEC2 (41020940 - 41032630 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for APOBEC2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOBEC2
    DNA2.0 Custom Variant and Variant Library Synthesis for APOBEC2

    Disorders / Diseases
    for APOBEC2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APOBEC2 for disorders           About GeneDecksing

    OMIM gene information: 604797    OMIM disorders: --

    4 diseases for APOBEC2:    About MalaCards
    tonsillitis    immunodeficiency    thyroiditis    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: APOBEC2 (1 document)

    Export disorders for APOBEC2 gene to outside databases

    Publications
    for APOBEC2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOBEC2 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with APOBEC2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. (PubMed id 10403781)1, 2, 3, 9 Liao W.... Chan L. (1999)
    2. The APOBEC-2 crystal structure and functional implications for the deaminase AID. (PubMed id 17187054)1, 2, 9 Prochnow C....Chen X.S. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing. (PubMed id 11698249)1, 9 Anant S....Davidson N.O. (2001)
    6. Excessive activity of apolipoprotein B mRNA editing en zyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenes is. (PubMed id 21469143)1 Okuyama S....Chiba T. (2012)
    7. Hydroxylation of 5-methylcytosine by TET1 promotes ac tive DNA demethylation in the adult brain. (PubMed id 21496894)2 Guo J.U....Song H. (2011)
    8. Microarray analysis of tonsils in immunoglobulin A ne phropathy patients. (PubMed id 20138841)1 Iio K....Rakugi H. (2010)
    9. APOBEC deaminases-mutases with defensive roles for im munity. (PubMed id 19911124)1 Prochnow C....Chen X.S. (2009)
    10. Gender differences in genetic risk profiles for cardiovascular disease. (PubMed id 18974842)1 Silander K....Peltonen L. (2008)

    External Searches for APOBEC2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing APOBEC2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10930 HGNC: 605 AceView: APOBEC2 Ensembl:ENSG00000124701 euGenes: HUgn10930
    ECgene: APOBEC2 H-InvDB: APOBEC2

    Other Databases showing APOBEC2 gene

    (According to HUGE)
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    Specialized Databases showing APOBEC2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOBEC2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for APOBEC2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for APOBEC2 gene:
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