Free for academic non-profit institutions. Other users need a Commercial license

Aliases for APOBEC2 Gene

Aliases for APOBEC2 Gene

  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 2 2 3
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 2 3
  • Probable C->U-Editing Enzyme APOBEC-2 3
  • EC 3.5.4.- 4
  • EC 3.5.4 64
  • ARCD1 3
  • Arp1 3

External Ids for APOBEC2 Gene

Summaries for APOBEC2 Gene

GeneCards Summary for APOBEC2 Gene

APOBEC2 (Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and cytidine deaminase activity. An important paralog of this gene is AICDA.

UniProtKB/Swiss-Prot for APOBEC2 Gene

  • Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Gene Wiki entry for APOBEC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC2 Gene

Genomics for APOBEC2 Gene

Genomic Location for APOBEC2 Gene

Start:
41,053,201 bp from pter
End:
41,064,891 bp from pter
Size:
11,691 bases
Orientation:
Plus strand

Genomic View for APOBEC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOBEC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBEC2 Gene

Regulatory Elements for APOBEC2 Gene

Proteins for APOBEC2 Gene

  • Protein details for APOBEC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y235-ABEC2_HUMAN
    Recommended name:
    Probable C->U-editing enzyme APOBEC-2
    Protein Accession:
    Q9Y235
    Secondary Accessions:
    • B2R899
    • Q53F28
    • Q5TGU5
    • Q5TGU6

    Protein attributes for APOBEC2 Gene

    Size:
    224 amino acids
    Molecular mass:
    25703 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for APOBEC2 Gene

neXtProt entry for APOBEC2 Gene

Proteomics data for APOBEC2 Gene at MOPED

Selected DME Specific Peptides for APOBEC2 Gene

Post-translational modifications for APOBEC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOBEC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for APOBEC2 Gene

Gene Families for APOBEC2 Gene

HGNC:
  • APOBEC :Apolipoprotein B mRNA editing enzymes

UniProtKB/Swiss-Prot:

ABEC2_HUMAN
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.:
    • Q9Y235
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.:
    • Q9Y235
genes like me logo Genes that share domains with APOBEC2: view

Function for APOBEC2 Gene

Molecular function for APOBEC2 Gene

GENATLAS Biochemistry: apolipoprotein B,mRNA editing enzyme,catalytic polypeptide 2,expressed exclusively in heart and skeletal muscle
UniProtKB/Swiss-Prot Function: Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Enzyme Numbers (IUBMB) for APOBEC2 Gene

Gene Ontology (GO) - Molecular Function for APOBEC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 10403781
GO:0003824 catalytic activity --
GO:0004126 cytidine deaminase activity TAS 10403781
GO:0008270 zinc ion binding IEA --
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines --
genes like me logo Genes that share ontologies with APOBEC2: view
genes like me logo Genes that share phenotypes with APOBEC2: view

Animal Models for APOBEC2 Gene

MGI Knock Outs for APOBEC2:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for APOBEC2 Gene

Localization for APOBEC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOBEC2 Gene COMPARTMENTS Subcellular localization image for APOBEC2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for APOBEC2 Gene

Pathways for APOBEC2 Gene

SuperPathways for APOBEC2 Gene

No Data Available

Interacting Proteins for APOBEC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244669%0d%0a9606.ENSP00000229304%0d%0a
Selected Interacting proteins: ENSP00000244669 Q9Y235-ABEC2_HUMAN for APOBEC2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for APOBEC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0009972 cytidine deamination TAS 10403781
GO:0016556 mRNA modification IEA --
GO:0080111 DNA demethylation IDA 21496894
genes like me logo Genes that share ontologies with APOBEC2: view

No data available for Pathways by source for APOBEC2 Gene

Compounds for APOBEC2 Gene

(3) Novoseek inferred chemical compound relationships for APOBEC2 Gene

Compound -log(P) Hits PubMed IDs
cytidine 86.6 9
retinoic acid 22.1 1
steroid 5.65 3
genes like me logo Genes that share compounds with APOBEC2: view

Transcripts for APOBEC2 Gene

mRNA/cDNA for APOBEC2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOBEC2 Gene

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC2 Gene

No ASD Table

Relevant External Links for APOBEC2 Gene

GeneLoc Exon Structure for
APOBEC2
ECgene alternative splicing isoforms for
APOBEC2

Expression for APOBEC2 Gene

mRNA expression in normal human tissues for APOBEC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOBEC2 Gene

This gene is overexpressed in Muscle - Skeletal (26.9), Heart - Left Ventricle (17.0), and Heart - Atrial Appendage (5.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for APOBEC2 Gene

SOURCE GeneReport for Unigene cluster for APOBEC2 Gene Hs.555915

mRNA Expression by UniProt/SwissProt for APOBEC2 Gene

Q9Y235-ABEC2_HUMAN
Tissue specificity: Expressed exclusively in heart and skeletal muscle
genes like me logo Genes that share expressions with APOBEC2: view

Orthologs for APOBEC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOBEC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOBEC2 36
  • 99.4 (n)
  • 99.4 (a)
APOBEC2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOBEC2 36
  • 86.76 (n)
  • 90.62 (a)
APOBEC2 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOBEC2 36
  • 89.14 (n)
  • 94.64 (a)
APOBEC2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apobec2 36
  • 87.95 (n)
  • 90.62 (a)
Apobec2 16
Apobec2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APOBEC2 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APOBEC2 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apobec2 36
  • 87.95 (n)
  • 91.52 (a)
chicken
(Gallus gallus)
Aves APOBEC2 36
  • 73.56 (n)
  • 79.33 (a)
APOBEC2 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APOBEC2 37
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5876 36
tropical clawed frog
(Silurana tropicalis)
Amphibia apobec2 36
  • 60.78 (n)
  • 57.35 (a)
Str.11906 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2129 36
zebrafish
(Danio rerio)
Actinopterygii APOBEC2 (2 of 2) 37
  • 46 (a)
OneToMany
apobec2a 36
  • 64.18 (n)
  • 62.19 (a)
apobec2a 37
  • 46 (a)
OneToMany
Species with no ortholog for APOBEC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOBEC2 Gene

ENSEMBL:
Gene Tree for APOBEC2 (if available)
TreeFam:
Gene Tree for APOBEC2 (if available)

Paralogs for APOBEC2 Gene

Selected SIMAP similar genes for APOBEC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APOBEC2: view

Variants for APOBEC2 Gene

Sequence variations from dbSNP and Humsavar for APOBEC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs879491 -- 41,059,214(+) CACAC(A/G)GCAGC intron-variant
rs1014737 -- 41,054,978(+) AAGGG(A/T)TAAGT intron-variant
rs1065197 -- 41,061,749(+) ACTTC(A/G)AATAT missense, reference
rs2057001 -- 41,055,208(+) CTGGT(C/T)TCTTA intron-variant
rs2057002 -- 41,055,223(+) TTCTG(G/T)ATCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOBEC2 Gene

Variant ID Type Subtype PubMed ID
nsv526577 CNV Loss 19592680

Relevant External Links for APOBEC2 Gene

HapMap Linkage Disequilibrium report
APOBEC2

Disorders for APOBEC2 Gene

Relevant External Links for APOBEC2

Genetic Association Database (GAD)
APOBEC2
Human Genome Epidemiology (HuGE) Navigator
APOBEC2
genes like me logo Genes that share disorders with APOBEC2: view

No data available for UniProtKB/Swiss-Prot for APOBEC2 Gene

Publications for APOBEC2 Gene

  1. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. (PMID: 10403781) Liao W. … Chan L. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. The APOBEC-2 crystal structure and functional implications for the deaminase AID. (PMID: 17187054) Prochnow C. … Chen X.S. (Nature 2007) 3 4 23
  3. ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing. (PMID: 11698249) Anant S. … Davidson N.O. (Am. J. Physiol., Cell Physiol. 2001) 3 23
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for APOBEC2 Gene

Sources for APOBEC2 Gene

Back to Top

Content