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Aliases for APOBEC2 Gene

Aliases for APOBEC2 Gene

  • Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 2 2 3
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 2 2 3 5
  • MRNA(Cytosine(6666)) Deaminase 2 3 4
  • Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide Like 2 3
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 2 3
  • Probable C->U-Editing Enzyme APOBEC-2 3
  • EC 3.5.4.36 4
  • EC 3.5.4 63
  • ARCD1 3
  • ARP1 3

External Ids for APOBEC2 Gene

Previous GeneCards Identifiers for APOBEC2 Gene

  • GC06P041023
  • GC06P041067
  • GC06P041128
  • GC06P040738

Summaries for APOBEC2 Gene

GeneCards Summary for APOBEC2 Gene

APOBEC2 (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and cytidine deaminase activity. An important paralog of this gene is AICDA.

UniProtKB/Swiss-Prot for APOBEC2 Gene

  • Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Gene Wiki entry for APOBEC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBEC2 Gene

Genomics for APOBEC2 Gene

Regulatory Elements for APOBEC2 Gene

Promoters for APOBEC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOBEC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOBEC2 Gene

Chromosome:
6
Start:
41,053,201 bp from pter
End:
41,064,891 bp from pter
Size:
11,691 bases
Orientation:
Plus strand

Genomic View for APOBEC2 Gene

Genes around APOBEC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOBEC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOBEC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBEC2 Gene

Proteins for APOBEC2 Gene

  • Protein details for APOBEC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y235-ABEC2_HUMAN
    Recommended name:
    C->U-editing enzyme APOBEC-2
    Protein Accession:
    Q9Y235
    Secondary Accessions:
    • B2R899
    • Q53F28
    • Q5TGU5
    • Q5TGU6

    Protein attributes for APOBEC2 Gene

    Size:
    224 amino acids
    Molecular mass:
    25703 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for APOBEC2 Gene

neXtProt entry for APOBEC2 Gene

Proteomics data for APOBEC2 Gene at MOPED

Selected DME Specific Peptides for APOBEC2 Gene

Post-translational modifications for APOBEC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOBEC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for APOBEC2 Gene

Suggested Antigen Peptide Sequences for APOBEC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y235

UniProtKB/Swiss-Prot:

ABEC2_HUMAN :
  • Contains 1 CMP/dCMP-type deaminase domain.
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with APOBEC2: view

Function for APOBEC2 Gene

Molecular function for APOBEC2 Gene

GENATLAS Biochemistry:
apolipoprotein B,mRNA editing enzyme,catalytic polypeptide 2,expressed exclusively in heart and skeletal muscle
UniProtKB/Swiss-Prot CatalyticActivity:
Cytosine(6666) in apolipoprotein B mRNA + H(2)O = uracil(6666) in apolipoprotein B mRNA + NH(3).
UniProtKB/Swiss-Prot Function:
Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Enzyme Numbers (IUBMB) for APOBEC2 Gene

Gene Ontology (GO) - Molecular Function for APOBEC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA --
genes like me logo Genes that share ontologies with APOBEC2: view
genes like me logo Genes that share phenotypes with APOBEC2: view

Animal Models for APOBEC2 Gene

MGI Knock Outs for APOBEC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for APOBEC2

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for APOBEC2 Gene

Localization for APOBEC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOBEC2 Gene COMPARTMENTS Subcellular localization image for APOBEC2 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for APOBEC2 Gene

Pathways & Interactions for APOBEC2 Gene

SuperPathways for APOBEC2 Gene

No Data Available

Interacting Proteins for APOBEC2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244669%0d%0a9606.ENSP00000229304%0d%0a
Selected Interacting proteins: Q9Y235-ABEC2_HUMAN ENSP00000244669 for APOBEC2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for APOBEC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for APOBEC2 Gene

Drugs & Compounds for APOBEC2 Gene

(1) Drugs for APOBEC2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for APOBEC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APOBEC2: view

Transcripts for APOBEC2 Gene

mRNA/cDNA for APOBEC2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(74) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOBEC2 Gene

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOBEC2 Gene

No ASD Table

Relevant External Links for APOBEC2 Gene

GeneLoc Exon Structure for
APOBEC2
ECgene alternative splicing isoforms for
APOBEC2

Expression for APOBEC2 Gene

mRNA expression in normal human tissues for APOBEC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOBEC2 Gene

This gene is overexpressed in Muscle - Skeletal (x26.9), Heart - Left Ventricle (x17.0), and Heart - Atrial Appendage (x5.4).

Protein differential expression in normal tissues from HIPED for APOBEC2 Gene

This gene is overexpressed in Esophagus (22.3), Fetal heart (19.4), Heart (12.1), and Tonsil (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOBEC2 Gene



SOURCE GeneReport for Unigene cluster for APOBEC2 Gene Hs.555915

mRNA Expression by UniProt/SwissProt for APOBEC2 Gene

Q9Y235-ABEC2_HUMAN
Tissue specificity: Expressed exclusively in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with APOBEC2: view

Protein tissue co-expression partners for APOBEC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for APOBEC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOBEC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOBEC2 35
  • 86.76 (n)
  • 90.62 (a)
APOBEC2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOBEC2 35
  • 89.14 (n)
  • 94.64 (a)
APOBEC2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apobec2 35
  • 87.95 (n)
  • 90.62 (a)
Apobec2 16
Apobec2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APOBEC2 35
  • 99.4 (n)
  • 99.4 (a)
APOBEC2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apobec2 35
  • 87.95 (n)
  • 91.52 (a)
oppossum
(Monodelphis domestica)
Mammalia APOBEC2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APOBEC2 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves APOBEC2 35
  • 73.56 (n)
  • 79.33 (a)
APOBEC2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APOBEC2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apobec2 35
  • 60.78 (n)
  • 57.35 (a)
Str.11906 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5876 35
zebrafish
(Danio rerio)
Actinopterygii apobec2a 35
  • 64.18 (n)
  • 62.19 (a)
APOBEC2 (2 of 2) 36
  • 46 (a)
OneToMany
apobec2a 36
  • 46 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2129 35
Species with no ortholog for APOBEC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOBEC2 Gene

ENSEMBL:
Gene Tree for APOBEC2 (if available)
TreeFam:
Gene Tree for APOBEC2 (if available)

Paralogs for APOBEC2 Gene

(10) SIMAP similar genes for APOBEC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APOBEC2: view

Variants for APOBEC2 Gene

Sequence variations from dbSNP and Humsavar for APOBEC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2076472 - 41,061,603(+) CATTA(C/T)CAAAA reference, missense
rs1014737 -- 41,054,978(+) AAGGG(A/T)TAAGT intron-variant
rs879491 -- 41,059,214(+) CACAC(A/G)GCAGC intron-variant
rs1065197 -- 41,061,749(+) ACTTC(A/G)AATAT reference, missense
rs2073014 -- 41,061,370(+) CGGAA(C/T)GTGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for APOBEC2 Gene

Variant ID Type Subtype PubMed ID
nsv526577 CNV Loss 19592680

Variation tolerance for APOBEC2 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.60; 78.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOBEC2 Gene

HapMap Linkage Disequilibrium report
APOBEC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBEC2 Gene

Disorders for APOBEC2 Gene

Relevant External Links for APOBEC2

Genetic Association Database (GAD)
APOBEC2
Human Genome Epidemiology (HuGE) Navigator
APOBEC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOBEC2

No disorders were found for APOBEC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBEC2 Gene

Publications for APOBEC2 Gene

  1. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. (PMID: 10403781) Liao W. … Chan L. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. The APOBEC-2 crystal structure and functional implications for the deaminase AID. (PMID: 17187054) Prochnow C. … Chen X.S. (Nature 2007) 3 23
  3. ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing. (PMID: 11698249) Anant S. … Davidson N.O. (Am. J. Physiol., Cell Physiol. 2001) 3 23
  4. Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis. (PMID: 21469143) Okuyama S. … Chiba T. (Int. J. Cancer 2012) 3
  5. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. (PMID: 21496894) Guo J.U. … Song H. (Cell 2011) 3

Products for APOBEC2 Gene

Sources for APOBEC2 Gene

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