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APOBEC1 Gene

protein-coding   GIFtS: 59
GCID: GC12M007801

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide...

  See APOBEC1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 11 2     CDAR12
Apolipoprotein B MRNA-Editing Enzyme 12 3     Apolipoprotein B MRNA Editing Enzyme Complex-12
HEPR2 3     C->U-Editing Enzyme APOBEC-12
BEDP2 5     EC 3.5.4.-3
APOBEC-12     EC 3.5.48

External Ids:    HGNC: 6041   Entrez Gene: 3392   Ensembl: ENSG000001117017   OMIM: 6001305   UniProtKB: P412383   

Export aliases for APOBEC1 gene to outside databases

Previous GC identifers: GC12M007674 GC12M007970 GC12M007693 GC12M007615


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOBEC1 Gene:
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein
editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This
holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1
mRNAs. (provided by RefSeq, Jul 2008)

GeneCards Summary for APOBEC1 Gene:
APOBEC1 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1) is a protein-coding gene. Diseases associated with APOBEC1 include neurofibromatosis. GO annotations related to this gene include cytidine deaminase activity and RNA binding. An important paralog of this gene is APOBEC3G.

UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238
Function: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the
postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA
(Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression
by participating in DNA demethylation

Gene Wiki entry for APOBEC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOBEC1 gene promoter:
         TBP   AP-1   Bach2   FOXD3   E47   PPAR-gamma1   FOXO4   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOBEC1 promoter sequence
   Search Chromatin IP Primers for APOBEC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOBEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.1

APOBEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007801:  view genomic region     (about GC identifiers)

Start:
7,801,996 bp from pter      End:
7,818,502 bp from pter
Size:
16,507 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238 (See protein sequence)
Recommended Name: C->U-editing enzyme APOBEC-1  
Size: 236 amino acids; 28192 Da
Cofactor: Zinc (By similarity)
Subunit: Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with
CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP
Secondary accessions: Q9UE64 Q9UM71

Explore the universe of human proteins at neXtProt for APOBEC1: NX_P41238

Explore proteomics data for APOBEC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for APOBEC1 (P41238)
     NRQGLRDL  SGVTIQIM  CSITWFLSWSPCWECS 


    See APOBEC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001635.2  
    ENSEMBL proteins: 
     ENSP00000229304   ENSP00000436415  
    Reactome Protein details: P41238

    APOBEC1 Human Recombinant Protein Products:

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    antibodies-online peptides for APOBEC1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    APOBEC: Apolipoprotein B mRNA editing enzymes

    3 InterPro protein domains:
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR013158 APOBEC_N
     IPR016193 Cytidine_deaminase-like

    Graphical View of Domain Structure for InterPro Entry P41238

    ProtoNet protein and cluster: P41238

    2 Blocks protein domains:
    IPB002125 Cytidine/deoxycytidylate deaminase
    IPB007904 APOBEC-like


    UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family


    Find genes that share domains with APOBEC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABEC1_HUMAN, P41238
    Function: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the
    postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA
    (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression
    by participating in DNA demethylation

         Genatlas biochemistry entry for APOBEC1:
    apolipoprotein B,mRNA editing component 1 (catalytic subunit),expressed in the small intestine and liver

         Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7736571
    GO:0003824catalytic activity ----
    GO:0004126cytidine deaminase activity TAS7736571
    GO:0005515protein binding IPI10669759
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with APOBEC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for APOBEC1:
     High actin ratio cells  Increased homologous recombina 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Apobec1):
     cardiovascular system  homeostasis/metabolism  mortality/aging  normal 

    Find genes that share phenotypes with APOBEC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for APOBEC1: Apobec1tm1Ddsn Apobec1tm1Ishi Apobec1tm1Chan Apobec1tm1Rub

       genOway: Develop your customized and physiologically relevant rodent model for APOBEC1

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    1 qRT-PCR Assays for microRNA that regulate APOBEC1:
    hsa-miR-526b
    SwitchGear 3'UTR luciferase reporter plasmidAPOBEC1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ABEC1_HUMAN, P41238: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with APOBEC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APOBEC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Formation of editosomes by ADAR proteins
    mRNA Editing0.50
    mRNA Editing- C to U Conversion0.00
    Formation of the Editosome0.50
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with APOBEC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for APOBEC1
        Formation of the Editosome
    mRNA Editing: C to U Conversion


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APOBEC1
    Interactions:

        GeneGlobe Interaction Network for APOBEC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for APOBEC1 (P412383 ENSP000002293044) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG4O954293, ENSP000002873224I2D: score=2 STRING: ENSP00000287322
    DNAJB11Q9UBS43, ENSP000002650284I2D: score=2 STRING: ENSP00000265028
    CELF2O953193, ENSP000003899514I2D: score=1 STRING: ENSP00000389951
    A1CFQ9NQ943, ENSP000002826414I2D: score=2 STRING: ENSP00000282641
    APOBEC2Q9Y2353, ENSP000002446694I2D: score=2 STRING: ENSP00000244669
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing TAS7736571
    GO:0006397mRNA processing IEA--
    GO:0006629lipid metabolic process TAS8078915
    GO:0006970response to osmotic stress IEA--
    GO:0009972cytidine deamination TAS7736571

    Find genes that share ontologies with APOBEC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for APOBEC1 (ABEC1)

    6 Novoseek inferred chemical compound relationships for APOBEC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 91.3 27 8407891 (2), 9822632 (2), 15780864 (2), 14978281 (1) (see all 22)
    uridine 66.6 6 11426934 (1), 11870221 (1), 9826530 (1), 10403781 (1) (see all 5)
    cytosine 52.3 2 17440614 (1), 17212712 (1)
    ethanol 14.9 4 9826530 (2), 11463337 (1), 10833526 (1)
    zinc 11.9 2 8407891 (1), 8208612 (1)
    lipid 0 1 17353585 (1)



    Find genes that share compounds with APOBEC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APOBEC1 gene (2 alternative transcripts): 
    NM_001644.3  NM_005889.2  

    Unigene Cluster for APOBEC1:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
    Hs.560  [show with all ESTs]
    Unigene Representative Sequence: NM_001644
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229304(uc001qtb.3) ENST00000467171(uc001qtc.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat APOBEC1
      QuantiFast Probe-based Assays in human, mouse, rat APOBEC1

    Additional mRNA sequence: 

    BC096158.1 BC096159.1 BC096160.1 BC096161.1 BC101404.1 BC101405.1 BC101972.1 BC101973.1 
    BC144708.1 L25877.1 L26234.1 U72890.1 U72891.1 U78720.1 

    2 DOTS entries:

    DT.100744025  DT.91730486 

    Selected AceView cDNA sequences (see all 67):

    AW848603 AW848325 AW376843 AW849099 AW849015 AW376538 AW376844 AW849089 
    AW849082 AW849098 AW848538 AW376531 AW849011 AW376542 AW848537 AW848743 
    AW849090 AW376539 AW848247 AW849083 AW849010 AW848260 AA587939 L25877 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOBEC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCAACAAA
    APOBEC1 Expression
    About this image


    APOBEC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
     
     Colon (Gastrointestinal Tract)
    APOBEC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOBEC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.560

    UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238
    Tissue specificity: Expressed exclusively in the small intestine

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for APOBEC1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apobec11 , 5 apolipoprotein B mRNA editing enzyme, catalytic polypeptide more1, 5 77.34(n)1
    71.05(a)1
      6 (57.68 cM)5
    118101  NM_031159.31  NP_112436.11 
     1225777925 
    lizard
    (Anolis carolinensis)
    Reptilia APOBEC16
    apolipoprotein B mRNA editing enzyme, catalytic po...
    39(a)
    1 ↔ 1
    2(81083205-81097885)


    ENSEMBL Gene Tree for APOBEC1 (if available)
    TreeFam Gene Tree for APOBEC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APOBEC1 gene
    APOBEC3G2  APOBEC3F2  APOBEC22  APOBEC3B2  APOBEC3D2  APOBEC3C2  APOBEC3A2  APOBEC3H2  
    AICDA2  
    3 SIMAP similar genes for APOBEC1 using alignment to 2 protein entries:     ABEC1_HUMAN (see all proteins):
    AICDA    AID    APOBEC3C

    Find genes that share paralogs with APOBEC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APOBEC1 (see all 498)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104313071,2
    C,F,A,H--7801532(+) atgaaG/Atcatc 1 -- ds500121Minor allele frequency- A:0.22NS EA NA CSA WA 2695
    rs1823209191,2
    --7801579(+) TCACTC/TGCTCT 1 -- ds50010--------
    rs1172184371,2
    C,F--7801588(+) CTGGGC/TCAGGT 1 -- ds50011Minor allele frequency- T:0.02EA 120
    rs79699761,2
    C,F,A,H--7801608(+) cacacT/Cggtaa 1 -- ds500112Minor allele frequency- C:0.27NA WA CSA EA 258
    rs79700731,2
    C,F,A,H--7801657(+) gagtcT/Caggac 1 -- ds500112Minor allele frequency- C:0.39NA WA CSA EA 375
    rs123191231,2
    C--7801673(+) gaccaC/Gcctgg 1 -- ds50010--------
    rs1889250981,2
    --7801839(+) TTGCCA/GGCCAT 1 -- ds50010--------
    rs1485901591,2
    C--7801906(+) TGCAGC/TGCTGG 1 -- ds50010--------
    rs1439508991,2
    --7801907(+) GCAGCA/GCTGGC 1 -- ds50010--------
    rs110550221,2
    C,F,H--7802036(+) CTACAG/CAGTTT 1 -- ut31 ese36Minor allele frequency- C:0.05NS EA CSA WA 538

    HapMap Linkage Disequilibrium report for APOBEC1 (7801996 - 7818502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for APOBEC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5e196CNV Duplication17116639
    nsv521241CNV Loss19592680
    nsv521149CNV Loss19592680
    dgv178n27CNV Loss19166990
    dgv263n67CNV Gain20364138
    nsv826213CNV Gain20364138
    nsv826216CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600130    OMIM disorders: --

    1 disease for APOBEC1:    
    About MalaCards
    neurofibromatosis


    Find genes that share disorders with APOBEC1           About GenesLikeMe

    7 Novoseek inferred disease relationships for APOBEC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 41.4 8 12808466 (1), 17847074 (1), 17212712 (1), 17267497 (1) (see all 8)
    hepatitis b 27.1 2 17212712 (1), 17036163 (1)
    neurofibromatosis type 1 26.2 3 11727199 (1), 11072063 (1)
    hepatocellular carcinoma 13.8 2 9633945 (1), 10597235 (1)
    hypercholesterolemia 6.12 1 11809850 (1)
    dysplasia 0 3 9633945 (1), 11072063 (1)
    tumors 0 2 11727199 (1), 10597235 (1)

    Genetic Association Database (GAD): APOBEC1
    Human Genome Epidemiology (HuGE) Navigator: APOBEC1 (5 documents)

    Export disorders for APOBEC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOBEC1 gene, integrated from 10 sources (see all 101):
    (articles sorted by number of sources associating them with APOBEC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease. (PubMed id 17696929)1, 4, 9 Schafmayer C....Tepel J. (Liver Int. 2007)
    2. Human apolipoprotein B RNA editing deaminase gene (APOBEC1). (PubMed id 9479499)1, 2, 9 Fujino T.... Scott J. (Genomics 1998)
    3. Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. (PubMed id 8208612)1, 2, 9 Hadjiagapiou C....Davidson N.O. (Nucleic Acids Res. 1994)
    4. C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme. (PubMed id 11727199)1, 2, 9 Mukhopadhyay D....Davidson N.O. (Am. J. Hum. Genet. 2002)
    5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. (PubMed id 11352648)1, 2 Lau P.P.... Chan L. (Biochem. Biophys. Res. Commun. 2001)
    8. Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PubMed id 8999813)1, 2 Lau P.P.... Chan L. (J. Biol. Chem. 1997)
    9. Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide. (PubMed id 9186903)1, 2 Hirano K.... Davidson N.O. (J. Lipid Res. 1997)
    10. Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. (PubMed id 8078915)1, 2 Lau P.P.... Chan L. (Proc. Natl. Acad. Sci. U.S.A. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339 HGNC: 604 AceView: APOBEC1 Ensembl:ENSG00000111701 euGenes: HUgn339
    ECgene: APOBEC1 H-InvDB: APOBEC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for APOBEC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APOBEC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for APOBEC1 gene:
    Search GeneIP for patents involving APOBEC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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