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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOBEC1 Gene

protein-coding   GIFtS: 60
GCID: GC12M007801

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide...
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Aliases
for APOBEC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 11 2     CDAR12
Apolipoprotein B MRNA-Editing Enzyme 12 3     Apolipoprotein B MRNA Editing Enzyme Complex-12
HEPR2 3     C->U-Editing Enzyme APOBEC-12
BEDP2 5     EC 3.5.4.-3
APOBEC-12     EC 3.5.48

External Ids:    HGNC: 6041   Entrez Gene: 3392   Ensembl: ENSG000001117017   OMIM: 6001305   UniProtKB: P412383   

Export aliases for APOBEC1 gene to outside databases

Previous GC identifers: GC12M007674 GC12M007970 GC12M007693 GC12M007615


Summaries
for APOBEC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for APOBEC1 Gene:
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein
editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is
involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. (provided by
RefSeq, Jul 2008)

GeneCards Summary for APOBEC1 Gene: 
APOBEC1 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1) is a protein-coding gene. Diseases associated with APOBEC1 include neurofibromatosis, and noma, and among its related super-pathways are mRNA Editing and Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include cytidine deaminase activity and RNA binding. An important paralog of this gene is APOBEC3G.

UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238
Function: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the
postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg)
to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by
participating in DNA demethylation

Gene Wiki entry for APOBEC1 Gene


Genomic Views
for APOBEC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOBEC1 gene promoter:
         TBP   AP-1   Bach2   FOXD3   E47   PPAR-gamma1   FOXO4   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOBEC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for APOBEC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOBEC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.1

APOBEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007801:  view genomic region     (about GC identifiers)

Start:
 7,801,996 bp from pter      End:
 7,818,502 bp from pter
Size:
 16,507 bases      Orientation:
 minus strand

Proteins
for APOBEC1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238 (See protein sequence)
Recommended Name: C->U-editing enzyme APOBEC-1  
Size: 236 amino acids; 28192 Da
Cofactor: Zinc (By similarity)
Subunit: Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with CELF2/CUGBP2
and A1CF. Interacts with HNRPAB and SYNCRIP
Subcellular location: Cytoplasm
Secondary accessions: Q9UE64 Q9UM71

Explore the universe of human proteins at neXtProt for APOBEC1: NX_P41238

Explore proteomics data for APOBEC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41238

    • 3 DME Specific Peptides for APOBEC1 (P41238)
     NRQGLRDL  SGVTIQIM  CSITWFLSWSPCWECS 

    APOBEC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APOBEC1 Protein Expression
    REFSEQ proteins: NP_001635.2  
    ENSEMBL proteins: 
     ENSP00000229304   ENSP00000436415  
    Reactome Protein details: P41238
    Human Recombinant Protein Products for APOBEC1: 
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    OriGene Protein Over-expression Lysate for APOBEC1
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    Novus Biologicals APOBEC1 Protein
    Novus Biologicals APOBEC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for APOBEC1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--

    APOBEC1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for APOBEC1 
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    Protein Domains /
    Families
    for APOBEC1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    APOBEC: Apolipoprotein B mRNA editing enzymes

    2 InterPro protein domains:
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR013158 APOBEC_N

    Graphical View of Domain Structure for InterPro Entry P41238

    ProtoNet protein and cluster: P41238

    2 Blocks protein domains:
    IPB002125 Cytidine/deoxycytidylate deaminase
    IPB007904 APOBEC-like


    UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family


    APOBEC1 for domains           About GeneDecksing


    Function
    for APOBEC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ABEC1_HUMAN, P41238
    Function: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the
    postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg)
    to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by
    participating in DNA demethylation

         Genatlas biochemistry entry for APOBEC1:
    apolipoprotein B,mRNA editing component 1 (catalytic subunit),expressed in the small intestine and liver

         Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7736571
    GO:0003824catalytic activity ----
    GO:0004126cytidine deaminase activity TAS7736571
    GO:0005515protein binding IPI10669759
    GO:0008270zinc ion binding IEA--
         
    APOBEC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for APOBEC1:
     High actin ratio cells  Increased homologous recombina 

         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Apobec1):
     cardiovascular system  homeostasis/metabolism  mortality/aging  normal 

    APOBEC1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for APOBEC1: Apobec1tm1Ddsn Apobec1tm1Ishi Apobec1tm1Chan Apobec1tm1Rub
       inGenious Targeting Laboratory - Custom generated mouse model solutions for APOBEC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APOBEC1

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOBEC1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate APOBEC1:
    hsa-miR-526b
    SwitchGear 3'UTR luciferase reporter plasmid: APOBEC1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for APOBEC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APOBEC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Formation of editosomes by ADAR proteins
    		mRNA Editing0.50
    		mRNA Editing: C to U Conversion0.50
    		Formation of the Editosome0.50
    2mRNA Splicing - Major Pathway
    		mRNA Processing0.85
    3Generic Transcription Pathway
    		Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for APOBEC1
        Formation of the Editosome
    mRNA Editing
    Gene Expression
    mRNA Editing: C to U Conversion
    mRNA Processing



    APOBEC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APOBEC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for APOBEC1 (P412383 ENSP000002293044) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG4O954293, ENSP000002873224I2D: score=2 STRING: ENSP00000287322
    DNAJB11Q9UBS43, ENSP000002650284I2D: score=2 STRING: ENSP00000265028
    CELF2O953193, ENSP000003899514I2D: score=1 STRING: ENSP00000389951
    A1CFQ9NQ943, ENSP000002826414I2D: score=2 STRING: ENSP00000282641
    APOBEC2Q9Y2353, ENSP000002446694I2D: score=2 STRING: ENSP00000244669
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing TAS7736571
    GO:0006397mRNA processing IEA--
    GO:0006629lipid metabolic process TAS8078915
    GO:0006970response to osmotic stress IEA--
    GO:0009972cytidine deamination TAS7736571

    APOBEC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for APOBEC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOBEC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOBEC1 (ABEC1)

    6 Novoseek inferred chemical compound relationships for APOBEC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 91.3 27 8407891 (2), 9822632 (2), 15780864 (2), 14978281 (1) (see all 22)
    uridine 66.6 6 11426934 (1), 11870221 (1), 9826530 (1), 10403781 (1) (see all 5)
    cytosine 52.3 2 17440614 (1), 17212712 (1)
    ethanol 14.9 4 9826530 (2), 11463337 (1), 10833526 (1)
    zinc 11.9 2 8407891 (1), 8208612 (1)
    lipid 0 1 17353585 (1)

    Search CenterWatch for drugs/clinical trials and news about APOBEC1 / ABEC1

    Transcripts
    for APOBEC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APOBEC1 gene (2 alternative transcripts): 
    NM_001644.3  NM_005889.2  

    Unigene Cluster for APOBEC1:

    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
    Hs.560  [show with all ESTs]
    Unigene Representative Sequence: NM_001644
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229304(uc001qtb.3) ENST00000467171(uc001qtc.3)

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate APOBEC1:
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    Inhib. RNA
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    Additional mRNA sequence: 

    BC096158.1 BC096159.1 BC096160.1 BC096161.1 BC101404.1 BC101405.1 BC101972.1 BC101973.1 
    BC144708.1 L25877.1 L26234.1 U72890.1 U72891.1 U78720.1 

    2 DOTS entries:

    DT.100744025  DT.91730486 

    24/67 AceView cDNA sequences (see all 67):

    AW849011 AW849090 AW848325 AW848260 AW849010 AW376542 AW849082 AW376531 
    AW848247 AW848537 AW849098 AW376844 AW848538 AW848743 AW848603 AW849099 
    AW376538 AW376539 AW849015 AW376843 AW849089 AW849083 L26234 AI732653 

    GeneLoc Exon Structure


    Expression
    for APOBEC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOBEC1 expression in normal human tissues (normalized intensities)      APOBEC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCAACAAA
    APOBEC1 Expression
    About this image


    APOBEC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts

     -- (Gastrointestinal Tract)
             colon

    See APOBEC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOBEC1

    SOURCE GeneReport for Unigene cluster: Hs.560

    UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238
    Tissue specificity: Expressed exclusively in the small intestine

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    In Situ
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    Orthologs
    for APOBEC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for APOBEC1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Apobec11 , 5 apolipoprotein B mRNA editing enzyme, catalytic polypeptide more1, 5 77.34(n)1
    71.05(a)1    		   6 (57.68 cM)5
    118101  NM_001134391.11  NP_001127863.11 
     1225777925 
    lizard
    (Anolis carolinensis)    		 Reptilia APOBEC16
    APOBEC16
    		 Uncharacterized protein
    		 39(a)
    19(a)
    		 1 ↔ 1
    possible ortholog
    		 2(81083205-81097885)
    3(98127718-98134621)


    ENSEMBL Gene Tree for APOBEC1 (if available)
    TreeFam Gene Tree for APOBEC1 (if available)

    Paralogs
    for APOBEC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOBEC1 gene
    APOBEC3G2  APOBEC3F2  APOBEC22  APOBEC3B2  APOBEC3D2  APOBEC3C2  APOBEC3A2  APOBEC3H2  
    AICDA2  
    3 SIMAP similar genes for APOBEC1 using alignment to 2 protein entries:     ABEC1_HUMAN (see all proteins):
    AICDA    AID    APOBEC3C

    APOBEC1 for paralogs           About GeneDecksing



    Genomic Variants
    for APOBEC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/498 SNPs in APOBEC1 are shown (see all 498)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs104313071,2
    		C,F,A,H--7801532(+) atgaaG/Atcatc 1 -- ds500121Minor allele frequency- A:0.22NS EA NA CSA WA 2695
    rs1823209191,2
    		--7801579(+) TCACTC/TGCTCT 1 -- ds50010--------
    rs1172184371,2
    		C,F--7801588(+) CTGGGC/TCAGGT 1 -- ds50011Minor allele frequency- T:0.02EA 120
    rs79699761,2
    		C,F,A,H--7801608(+) cacacT/Cggtaa 1 -- ds500112Minor allele frequency- C:0.27NA WA CSA EA 258
    rs79700731,2
    		C,F,A,H--7801657(+) gagtcT/Caggac 1 -- ds500112Minor allele frequency- C:0.39NA WA CSA EA 375
    rs123191231,2
    		C--7801673(+) gaccaC/Gcctgg 1 -- ds50010--------
    rs1889250981,2
    		--7801839(+) TTGCCA/GGCCAT 1 -- ds50010--------
    rs1485901591,2
    		C--7801906(+) TGCAGC/TGCTGG 1 -- ds50010--------
    rs1439508991,2
    		--7801907(+) GCAGCA/GCTGGC 1 -- ds50010--------
    rs110550221,2
    		C,F,H--7802036(+) CTACAG/CAGTTT 1 -- ut31 ese36Minor allele frequency- C:0.05NS EA CSA WA 538

    HapMap Linkage Disequilibrium report for APOBEC1 (7801996 - 7818502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for APOBEC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv5e196CNV Duplication17116639
    nsv521241CNV Loss19592680
    nsv521149CNV Loss19592680
    dgv178n27CNV Loss19166990
    dgv263n67CNV Gain20364138
    nsv826213CNV Gain20364138
    nsv826216CNV Gain20364138

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    Disorders / Diseases
    for APOBEC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APOBEC1 for disorders           About GeneDecksing

    OMIM gene information: 600130    OMIM disorders: --

    10 diseases for APOBEC1:    About MalaCards
    neurofibromatosis    noma    hypercholesterolemia    hepatitis b
    psoriasis    hepatitis c    hepatitis    atherosclerosis
    retinitis    neuronitis


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    7 Novoseek inferred disease relationships for APOBEC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 41.4 8 12808466 (1), 17847074 (1), 17212712 (1), 17267497 (1) (see all 8)
    hepatitis b 27.1 2 17212712 (1), 17036163 (1)
    neurofibromatosis type 1 26.2 3 11727199 (1), 11072063 (1)
    hepatocellular carcinoma 13.8 2 9633945 (1), 10597235 (1)
    hypercholesterolemia 6.12 1 11809850 (1)
    dysplasia 0 3 9633945 (1), 11072063 (1)
    tumors 0 2 11727199 (1), 10597235 (1)

    Genetic Association Database (GAD): APOBEC1
    Human Genome Epidemiology (HuGE) Navigator: APOBEC1 (5 documents)

    Export disorders for APOBEC1 gene to outside databases

    Publications
    for APOBEC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOBEC1 gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with APOBEC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease. (PubMed id 17696929)1, 4, 9 Schafmayer C....Tepel J. (2007)
    2. Human apolipoprotein B RNA editing deaminase gene (APOBEC1). (PubMed id 9479499)1, 2, 9 Fujino T.... Scott J. (1998)
    3. Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. (PubMed id 8208612)1, 2, 9 Hadjiagapiou C....Davidson N.O. (1994)
    4. C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme. (PubMed id 11727199)1, 2, 9 Mukhopadhyay D....Davidson N.O. (2002)
    5. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. (PubMed id 11352648)1, 2 Lau P.P.... Chan L. (2001)
    8. Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PubMed id 8999813)1, 2 Lau P.P.... Chan L. (1997)
    9. Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide. (PubMed id 9186903)1, 2 Hirano K.... Davidson N.O. (1997)
    10. Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. (PubMed id 8078915)1, 2 Lau P.P.... Chan L. (1994)

    External Searches for APOBEC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing APOBEC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339 HGNC: 604 AceView: APOBEC1 Ensembl:ENSG00000111701 euGenes: HUgn339
    ECgene: APOBEC1 H-InvDB: APOBEC1

    Other Databases showing APOBEC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing APOBEC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOBEC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APOBEC1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for APOBEC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for APOBEC1 gene:
    Search GeneIP for patents involving APOBEC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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