APOBEC1 Gene

Aliases
for APOBEC1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC12M007674 GC12M007970 GC12M007693 GC12M007615

Summaries
for APOBEC1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for APOBEC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000012.11  NT_009714.18  NC_018923.2  

SwitchGear Promoter luciferase reporter plasmid: APOBEC1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOBEC1

APOBEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007801:  view genomic region     (about GC identifiers)

Proteins
for APOBEC1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Explore the universe of human proteins at neXtProt for APOBEC1: NX_P41238

Explore proteomics data for APOBEC1 at MOPED

Post-translational modifications: 

APOBEC1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for APOBEC1 OriGene Custom MassSpec OriGene Custom Protein Services for APOBEC1
	GenScript Custom Purified and Recombinant Proteins Services for APOBEC1
	Novus Biologicals APOBEC1 Protein Novus Biologicals APOBEC1 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for APOBEC1
	Search eBioscience for Proteins for APOBEC1
	Search GeneTex for Proteins for APOBEC1
	antibodies-online proteins for APOBEC1 (8 products)
	antibodies-online peptides for APOBEC1

APOBEC1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of APOBEC1
	Browse R&D Systems for Antibodies
	OriGene Antibodies for APOBEC1 OriGene Custom Antibody Services for APOBEC1
	Novus Biologicals APOBEC1 Antibodies
	Abcam antibodies for APOBEC1
	Cloud-Clone Corp. Antibodies for APOBEC1
	ThermoFisher Antibody for APOBEC1
	antibodies-online antibodies for APOBEC1 (33 products)

APOBEC1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for APOBEC1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for APOBEC1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for APOBEC1 Cloud-Clone Corp. CLIAs for APOBEC1
	Search eBioscience for ELISAs for APOBEC1
	antibodies-online kits for APOBEC1 (8 products)

Domains /
Families
for APOBEC1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: P41238

Find genes that share domains with APOBEC1           About GenesLikeMe

Function
for APOBEC1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

(inferred from 4 alleles) (MGI details for Apobec1)

genOway: Develop your customized and physiologically relevant rodent model for APOBEC1

miRNA Products:		Block miRNA regulation of human, mouse, rat APOBEC1 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate APOBEC1:
		hsa-miR-526b
		SwitchGear 3'UTR luciferase reporter plasmid: APOBEC1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for APOBEC1
		Predesigned siRNA for gene silencing in human, mouse, rat APOBEC1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for APOBEC1

Clone Products:		OriGene clones in human, mouse for APOBEC1 (see all 7) OriGene ORF clones in mouse, rat for APOBEC1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APOBEC1 (NM_001644)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOBEC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for APOBEC1
		Browse ESI BIO Cell Lines and PureStem Progenitors for APOBEC1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC1

Localization
for APOBEC1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	4
cytosol	2
peroxisome	1

About this image

Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for APOBEC1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for APOBEC1 About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	Formation of editosomes by ADAR proteins	mRNA Editing 0.50 mRNA Editing- C to U Conversion 0.00 Formation of the Editosome 0.50
2	Gene Expression	Gene Expression 0.40

2 Reactome Pathways for APOBEC1

	Formation of the Editosome
	mRNA Editing: C to U Conversion

Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

Drugs & Compounds
for APOBEC1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for APOBEC1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for APOBEC1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APOBEC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GATCAACAAA

About this image

Epithelial Cells
Duct Cells Pancreatic Ducts
Pancreas (Endocrine System)
Duct Cells Pancreatic Ducts
Blood (Cardiovascular System)
Conventional Dendritic Cells II Spleen
Spleen (Hematopoietic System)
Conventional Dendritic Cells II Spleen
Colon (Gastrointestinal Tract)

Primer Products:		OriGene qPCR primer pairs and template standards for APOBEC1 OriGene qSTAR qPCR primer pairs in human, mouse for APOBEC1
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APOBEC1
		QuantiTect SYBR Green Assays in human, mouse, rat APOBEC1
		QuantiFast Probe-based Assays in human, mouse, rat APOBEC1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC1

Orthologs
for APOBEC1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for APOBEC1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for APOBEC1 gene

APOBEC3G²  APOBEC3F²  APOBEC2²  APOBEC3B²  APOBEC3D²  APOBEC3C²  APOBEC3A²  APOBEC3H²  

AICDA²  

3 SIMAP similar genes for APOBEC1 using alignment to 2 protein entries:     ABEC1_HUMAN (see all proteins):

AICDA    AID    APOBEC3C

Find genes that share paralogs with APOBEC1           About GenesLikeMe

Genomic Variants
for APOBEC1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for APOBEC1 (see all 498)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs104313071,2	C,F,A,H	--	7801532(+)	atgaaG/Atcatc	1	--	ds5001		21		NS EA NA CSA WA	2695
rs1823209191,2		--	7801579(+)	TCACTC/TGCTCT	1	--	ds5001		0	--	--	--	--
rs1172184371,2	C,F	--	7801588(+)	CTGGGC/TCAGGT	1	--	ds5001		1		EA	120
rs79699761,2	C,F,A,H	--	7801608(+)	cacacT/Cggtaa	1	--	ds5001		12		NA WA CSA EA	258
rs79700731,2	C,F,A,H	--	7801657(+)	gagtcT/Caggac	1	--	ds5001		12		NA WA CSA EA	375
rs123191231,2	C	--	7801673(+)	gaccaC/Gcctgg	1	--	ds5001		0	--	--	--	--
rs1889250981,2		--	7801839(+)	TTGCCA/GGCCAT	1	--	ds5001		0	--	--	--	--
rs1485901591,2	C	--	7801906(+)	TGCAGC/TGCTGG	1	--	ds5001		0	--	--	--	--
rs1439508991,2		--	7801907(+)	GCAGCA/GCTGGC	1	--	ds5001		0	--	--	--	--
rs110550221,2	C,F,H	--	7802036(+)	CTACAG/CAGTTT	1	--	ut31 ese3		6		NS EA CSA WA	538

HapMap Linkage Disequilibrium report for APOBEC1 (7801996 - 7818502 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for APOBEC1:    About this table    

Variant ID	Type	Subtype	PubMed ID
dgv5e196	CNV	Duplication	17116639
nsv521241	CNV	Loss	19592680
nsv521149	CNV	Loss	19592680
dgv178n27	CNV	Loss	19166990
dgv263n67	CNV	Gain	20364138
nsv826213	CNV	Gain	20364138
nsv826216	CNV	Gain	20364138

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing APOBEC1

DNA2.0 Custom Variant and Variant Library Synthesis for APOBEC1

Disorders / Diseases
for APOBEC1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

1 disease for APOBEC1

7 Novoseek inferred disease relationships for APOBEC1 gene    About this table

Publications
for APOBEC1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for APOBEC1 gene, integrated from 10 sources (see all 101): (articles sorted by number of sources associating them with APOBEC1)

Utopia: connect your pdf to the dynamic world of online information

1. Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease. (PubMed id 17696929)^{1, 4, 9} Schafmayer C....Tepel J. (Liver Int. 2007)
2. Human apolipoprotein B RNA editing deaminase gene (APOBEC1). (PubMed id 9479499)^{1, 2, 9} Fujino T.... Scott J. (Genomics 1998)
3. Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. (PubMed id 8208612)^{1, 2, 9} Hadjiagapiou C....Davidson N.O. (Nucleic Acids Res. 1994)
4. C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme. (PubMed id 11727199)^{1, 2, 9} Mukhopadhyay D....Davidson N.O. (Am. J. Hum. Genet. 2002)
5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)^{1, 4} Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
7. Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. (PubMed id 11352648)^{1, 2} Lau P.P.... Chan L. (Biochem. Biophys. Res. Commun. 2001)
8. Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PubMed id 8999813)^{1, 2} Lau P.P.... Chan L. (J. Biol. Chem. 1997)
9. Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide. (PubMed id 9186903)^{1, 2} Hirano K.... Davidson N.O. (J. Lipid Res. 1997)
10. Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. (PubMed id 8078915)^{1, 2} Lau P.P.... Chan L. (Proc. Natl. Acad. Sci. U.S.A. 1994)

External Searches for APOBEC1 gene

Genome Databases showing APOBEC1 gene

Other Databases showing APOBEC1 gene

Specialized Databases showing APOBEC1 gene

Products
for APOBEC1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section