Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

APOBEC1 Gene

protein-coding GIFtS: 59
GCID: GC12M007801

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide...

Pneumococci & Pneumococcal Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 1¹ ²		CDAR1²
Apolipoprotein B MRNA-Editing Enzyme 1² ³		Apolipoprotein B MRNA Editing Enzyme Complex-1²
HEPR² ³		C->U-Editing Enzyme APOBEC-1²
BEDP² ⁵		EC 3.5.4.-³
APOBEC-1²		EC 3.5.4⁸

External Ids:	HGNC: 604¹	Entrez Gene: 339²	Ensembl: ENSG00000111701⁷	OMIM: 600130⁵	UniProtKB: P41238³

Export aliases for APOBEC1 gene to outside databases

Previous GC identifers: GC12M007674 GC12M007970 GC12M007693 GC12M007615

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for APOBEC1 Gene:

This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein

editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This

holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1

mRNAs. (provided by RefSeq, Jul 2008)

GeneCards Summary for APOBEC1 Gene:

APOBEC1 (apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1) is a protein-coding gene. Diseases associated with APOBEC1 include neurofibromatosis, and noma. GO annotations related to this gene include cytidine deaminase activity and RNA binding. An important paralog of this gene is APOBEC3G.

UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238

Function: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the

postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA

(Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression

by participating in DNA demethylation

Gene Wiki entry for APOBEC1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000012.12 NT_009714.18 NC_018923.2

Regulatory elements:

Regulatory transcription factor binding sites in the APOBEC1 gene promoter:
TBP AP-1 Bach2 FOXD3 E47 PPAR-gamma1 FOXO4 FOXO1a PPAR-gamma2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOBEC1 promoter sequence

Search Chromatin IP Primers for APOBEC1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOBEC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.1

APOBEC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOBEC1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M007801: view genomic region (about GC identifiers)

Start:	7,801,996 bp from pter	End:	7,818,502 bp from pter
Size:	16,507 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238 (See protein sequence)

Recommended Name: C->U-editing enzyme APOBEC-1

Size: 236 amino acids; 28192 Da

Cofactor: Zinc (By similarity)

Subunit: Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with

CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP

Secondary accessions: Q9UE64 Q9UM71

Explore the universe of human proteins at neXtProt for APOBEC1: NX_P41238

Explore proteomics data for APOBEC1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

3 DME Specific Peptides for APOBEC1 (P41238)

NRQGLRDL

SGVTIQIM

CSITWFLSWSPCWECS

See APOBEC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001635.2

ENSEMBL proteins:

ENSP00000229304 ENSP00000436415

Reactome Protein details: P41238

APOBEC1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for APOBEC1 OriGene Custom MassSpec OriGene Custom Protein Services for APOBEC1
	GenScript Custom Purified and Recombinant Proteins Services for APOBEC1
	Novus Biologicals APOBEC1 Protein Novus Biologicals APOBEC1 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for APOBEC1

APOBEC1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of APOBEC1
	Browse R&D Systems for Antibodies
	OriGene Antibodies for APOBEC1 OriGene Custom Antibody Services for APOBEC1
	Novus Biologicals APOBEC1 Antibodies
	Abcam antibodies for APOBEC1
	Cloud-Clone Corp. Antibodies for APOBEC1
	ThermoFisher Antibody for APOBEC1
	LSBio Antibodies in human, mouse, rat for APOBEC1

APOBEC1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for APOBEC1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for APOBEC1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for APOBEC1 Cloud-Clone Corp. CLIAs for APOBEC1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

APOBEC: Apolipoprotein B mRNA editing enzymes

3 InterPro protein domains:

IPR016192 APOBEC/CMP_deaminase_Zn-bd

IPR013158 APOBEC_N

IPR016193 Cytidine_deaminase-like

Graphical View of Domain Structure for InterPro Entry P41238

ProtoNet protein and cluster: P41238

2 Blocks protein domains:

IPB002125 Cytidine/deoxycytidylate deaminase

IPB007904 APOBEC-like

UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family

APOBEC1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: ABEC1_HUMAN, P41238

Function: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the

postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA

(Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression

by participating in DNA demethylation

Genatlas biochemistry entry for APOBEC1:

apolipoprotein B,mRNA editing component 1 (catalytic subunit),expressed in the small intestine and liver

Enzyme Numbers (IUBMB): EC 3.5.4² EC 3.5.4.-¹

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	TAS	7736571
GO:0003824	catalytic activity	--	--
GO:0004126	cytidine deaminase activity	TAS	7736571
GO:0005515	protein binding	IPI	10669759
GO:0008270	zinc ion binding	IEA	--

APOBEC1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for APOBEC1:

High actin ratio cells

Increased homologous recombina

4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Apobec1):

cardiovascular system

homeostasis/metabolism

mortality/aging

normal

APOBEC1 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for APOBEC1: Apobec1^tm1Ddsn Apobec1^tm1Ishi Apobec1^tm1Chan Apobec1^tm1Rub

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOBEC1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APOBEC1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOBEC1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOBEC1

miRNA Products:		Block miRNA regulation of human, mouse, rat APOBEC1 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate APOBEC1:
		hsa-miR-526b
		SwitchGear 3'UTR luciferase reporter plasmid: APOBEC1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for APOBEC1
		Predesigned siRNA for gene silencing in human, mouse, rat APOBEC1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for APOBEC1

Clone Products:		OriGene clones in human, mouse for APOBEC1 (see all 7) OriGene ORF clones in mouse, rat for APOBEC1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APOBEC1 (NM_001644)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOBEC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for APOBEC1
		Browse ESI BIO Cell Lines and PureStem Progenitors for APOBEC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

ABEC1_HUMAN, P41238: Cytoplasm

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
cytosol	2
peroxisome	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IDA	--

APOBEC1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for APOBEC1 About

See pathways by source

SuperPath

Contained pathways About

Formation of editosomes by ADAR proteins

	mRNA Editing	0.50			mRNA Editing- C to U Conversion	0.00
	Formation of the Editosome	0.50

Gene Expression

Gene Expression

0.40

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for APOBEC1

	Formation of the Editosome
	mRNA Editing: C to U Conversion

APOBEC1 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for APOBEC1
Interactions:

GeneGlobe Interaction Network for APOBEC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for APOBEC1 (P41238³ ENSP00000229304⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAG4	O95429³, ENSP00000287322⁴	I2D: score=2 STRING: ENSP00000287322
DNAJB11	Q9UBS4³, ENSP00000265028⁴	I2D: score=2 STRING: ENSP00000265028
CELF2	O95319³, ENSP00000389951⁴	I2D: score=1 STRING: ENSP00000389951
A1CF	Q9NQ94³, ENSP00000282641⁴	I2D: score=2 STRING: ENSP00000282641
APOBEC2	Q9Y235³, ENSP00000244669⁴	I2D: score=2 STRING: ENSP00000244669

About this table

Gene Ontology (GO): Selected biological process terms (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006396	RNA processing	TAS	7736571
GO:0006397	mRNA processing	IEA	--
GO:0006629	lipid metabolic process	TAS	8078915
GO:0006970	response to osmotic stress	IEA	--
GO:0009972	cytidine deamination	TAS	7736571

APOBEC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for APOBEC1 (ABEC1)

6 Novoseek inferred chemical compound relationships for APOBEC1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cytidine	91.3	27	8407891 (2), 9822632 (2), 15780864 (2), 14978281 (1) (see all 22)
uridine	66.6	6	11426934 (1), 11870221 (1), 9826530 (1), 10403781 (1) (see all 5)
cytosine	52.3	2	17440614 (1), 17212712 (1)
ethanol	14.9	4	9826530 (2), 11463337 (1), 10833526 (1)
zinc	11.9	2	8407891 (1), 8208612 (1)
lipid	0	1	17353585 (1)

APOBEC1 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for APOBEC1 gene (2 alternative transcripts):

NM_001644.3 NM_005889.2

Unigene Cluster for APOBEC1:

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

Hs.560 [show with all ESTs]

Unigene Representative Sequence: NM_001644

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000229304(uc001qtb.3) ENST00000467171(uc001qtc.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat APOBEC1 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate APOBEC1:
		hsa-miR-526b
		SwitchGear 3'UTR luciferase reporter plasmid: APOBEC1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for APOBEC1
		Predesigned siRNA for gene silencing in human, mouse, rat APOBEC1

Clone Products:		OriGene clones in human, mouse for APOBEC1 (see all 7) OriGene ORF clones in mouse, rat for APOBEC1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APOBEC1 (NM_001644)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOBEC1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC1

Primer Products:		OriGene qPCR primer pairs and template standards for APOBEC1 OriGene qSTAR qPCR primer pairs in human, mouse for APOBEC1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat APOBEC1
		QuantiTect SYBR Green Assays in human, mouse, rat APOBEC1
		QuantiFast Probe-based Assays in human, mouse, rat APOBEC1

Additional mRNA sequence:

BC096158.1 BC096159.1 BC096160.1 BC096161.1 BC101404.1 BC101405.1 BC101972.1 BC101973.1

BC144708.1 L25877.1 L26234.1 U72890.1 U72891.1 U78720.1

2 DOTS entries:

DT.100744025 DT.91730486

Selected AceView cDNA sequences (see all 67):

AW848603 AW848325 AW376843 AW849099 AW849015 AW376538 AW376844 AW849089

AW849082 AW849098 AW848538 AW376531 AW849011 AW376542 AW848537 AW848743

AW849090 AW376539 AW848247 AW849083 AW849010 AW848260 AA587939 L25877

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

APOBEC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GATCAACAAA

About this image

APOBEC1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Epithelial Cells
Duct Cells Pancreatic Ducts

Pancreas (Endocrine System)
Duct Cells Pancreatic Ducts

Blood (Cardiovascular System)
Conventional Dendritic Cells II Spleen

Spleen (Hematopoietic System)
Conventional Dendritic Cells II Spleen

Colon (Gastrointestinal Tract)

APOBEC1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

APOBEC1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.560

UniProtKB/Swiss-Prot: ABEC1_HUMAN, P41238

Tissue specificity: Expressed exclusively in the small intestine

Custom PCR Arrays for APOBEC1

Primer Products:		OriGene qPCR primer pairs and template standards for APOBEC1 OriGene qSTAR qPCR primer pairs in human, mouse for APOBEC1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat APOBEC1
		QuantiTect SYBR Green Assays in human, mouse, rat APOBEC1
		QuantiFast Probe-based Assays in human, mouse, rat APOBEC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for APOBEC1 gene from Selected species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Apobec1^{1 , 5}	apolipoprotein B mRNA editing enzyme, catalytic polypeptide more^{1, 5}	77.34(n)¹ 71.05(a)¹		6 (57.68 cM)⁵ 11810¹ NM_031159.3¹ NP_112436.1¹ 122577792⁵
lizard (Anolis carolinensis)	Reptilia	APOBEC1⁶	apolipoprotein B mRNA editing enzyme, catalytic po...	39(a)	1 ↔ 1	2(81083205-81097885)

ENSEMBL Gene Tree for APOBEC1 (if available)
TreeFam Gene Tree for APOBEC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for APOBEC1 gene

APOBEC3G² APOBEC3F² APOBEC2² APOBEC3B² APOBEC3D² APOBEC3C² APOBEC3A² APOBEC3H²

AICDA²

3 SIMAP similar genes for APOBEC1 using alignment to 2 protein entries: ABEC1_HUMAN (see all proteins):

AICDA AID APOBEC3C

APOBEC1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10431307^1,2	C,F,A,H	--	7801532(+)	`atgaaG/Atcatc`	1	--	ds500¹		21		NS EA NA CSA WA	2695
rs182320919^1,2		--	7801579(+)	`TCACTC/TGCTCT`	1	--	ds500¹		0	--	--	--	--
rs117218437^1,2	C,F	--	7801588(+)	`CTGGGC/TCAGGT`	1	--	ds500¹		1		EA	120
rs7969976^1,2	C,F,A,H	--	7801608(+)	`cacacT/Cggtaa`	1	--	ds500¹		12		NA WA CSA EA	258
rs7970073^1,2	C,F,A,H	--	7801657(+)	`gagtcT/Caggac`	1	--	ds500¹		12		NA WA CSA EA	375
rs12319123^1,2	C	--	7801673(+)	`gaccaC/Gcctgg`	1	--	ds500¹		0	--	--	--	--
rs188925098^1,2		--	7801839(+)	`TTGCCA/GGCCAT`	1	--	ds500¹		0	--	--	--	--
rs148590159^1,2	C	--	7801906(+)	`TGCAGC/TGCTGG`	1	--	ds500¹		0	--	--	--	--
rs143950899^1,2		--	7801907(+)	`GCAGCA/GCTGGC`	1	--	ds500¹		0	--	--	--	--
rs11055022^1,2	C,F,H	--	7802036(+)	`CTACAG/CAGTTT`	1	--	ut3¹ ese³		6		NS EA CSA WA	538

HapMap Linkage Disequilibrium report for APOBEC1 (7801996 - 7818502 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for APOBEC1: About this table

Variant ID	Type	Subtype	PubMed ID
dgv5e196	CNV	Duplication	17116639
nsv521241	CNV	Loss	19592680
nsv521149	CNV	Loss	19592680
dgv178n27	CNV	Loss	19166990
dgv263n67	CNV	Gain	20364138
nsv826213	CNV	Gain	20364138
nsv826216	CNV	Gain	20364138

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing APOBEC1

DNA2.0 Custom Variant and Variant Library Synthesis for APOBEC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 600130 OMIM disorders: --

14 diseases for APOBEC1:
About MalaCards

neurofibromatosis noma hypercholesterolemia hepatitis b

hepatitis c virus hiv-1 psoriasis hepatitis c

hepatitis atherosclerosis retinitis hepatocellular carcinoma

neuronitis pancreatitis

APOBEC1 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

7 Novoseek inferred disease relationships for APOBEC1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	41.4	8	12808466 (1), 17847074 (1), 17212712 (1), 17267497 (1) (see all 8)
hepatitis b	27.1	2	17212712 (1), 17036163 (1)
neurofibromatosis type 1	26.2	3	11727199 (1), 11072063 (1)
hepatocellular carcinoma	13.8	2	9633945 (1), 10597235 (1)
hypercholesterolemia	6.12	1	11809850 (1)
dysplasia	0	3	9633945 (1), 11072063 (1)
tumors	0	2	11727199 (1), 10597235 (1)

Genetic Association Database (GAD): APOBEC1
Human Genome Epidemiology (HuGE) Navigator: APOBEC1 (5 documents)

Export disorders for APOBEC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for APOBEC1 gene, integrated from 10 sources (see all 101):
(articles sorted by number of sources associating them with APOBEC1)

Utopia: connect your pdf to the dynamic
world of online information

Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease. (PubMed id 17696929)^{1, 4, 9} Schafmayer C....Tepel J. (Liver Int. 2007)
Human apolipoprotein B RNA editing deaminase gene (APOBEC1). (PubMed id 9479499)^{1, 2, 9} Fujino T.... Scott J. (Genomics 1998)
Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein. (PubMed id 8208612)^{1, 2, 9} Hadjiagapiou C....Davidson N.O. (Nucleic Acids Res. 1994)
C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme. (PubMed id 11727199)^{1, 2, 9} Mukhopadhyay D....Davidson N.O. (Am. J. Hum. Genet. 2002)
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)^{1, 4} Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. (PubMed id 11352648)^{1, 2} Lau P.P.... Chan L. (Biochem. Biophys. Res. Commun. 2001)
Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PubMed id 8999813)^{1, 2} Lau P.P.... Chan L. (J. Biol. Chem. 1997)
Characterization of the human apobec-1 gene: expression in gastrointestinal tissues determined by alternative splicing with production of a novel truncated peptide. (PubMed id 9186903)^{1, 2} Hirano K.... Davidson N.O. (J. Lipid Res. 1997)
Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene. (PubMed id 8078915)^{1, 2} Lau P.P.... Chan L. (Proc. Natl. Acad. Sci. U.S.A. 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 339	HGNC: 604	AceView: APOBEC1	Ensembl:ENSG00000111701	euGenes: HUgn339
ECgene: APOBEC1	H-InvDB: APOBEC1

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for APOBEC1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for APOBEC1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for APOBEC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for APOBEC1 gene:
Search GeneIP for patents involving APOBEC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

	EMD Millipore Mono- and Polyclonal Antibodies for the study of APOBEC1
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for APOBEC1		OriGene RNAi products in human, mouse, rat for APOBEC1
	OriGene qPCR primer pairs and template standards for APOBEC1		OriGene Protein Over-expression Lysate for APOBEC1
	OriGene Custom Mass Spec		OriGene clones in human, mouse for APOBEC1
	OriGene qSTAR qPCR primer pairs in human, mouse for APOBEC1		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for APOBEC1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for APOBEC1		OriGene Custom Protein Services for APOBEC1

	Block miRNA regulation of human, mouse, rat APOBEC1 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing APOBEC1
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOBEC1		Predesigned siRNA for gene silencing in human, mouse, rat APOBEC1
	QuantiFast Probe-based Assays in human, mouse, rat APOBEC1		QuantiTect SYBR Green Assays in human, mouse, rat APOBEC1
	Custom PCR Arrays for APOBEC1		Search Chromatin IP Primers for APOBEC1
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat APOBEC1		GeneGlobe Interaction Network for APOBEC1
	Regulatory tfbs in APOBEC1 promoter

	GenScript Custom Purified and Recombinant Proteins Services for APOBEC1		GenScript cDNA clones with any tag delivered in your preferred vector for APOBEC1
	GenScript Custom Assay Services for APOBEC1		GenScript Custom overexpressing Cell Line Services for APOBEC1
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for APOBEC1 (ABEC1)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	APOBEC1 antibodies
	APOBEC1 proteins
	APOBEC1 lysates

	Antibodies for APOBEC1
	See all of Abcam's Antibodies, Kits and Proteins for APOBEC1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for APOBEC1
	Antibodies for APOBEC1
	ELISAs for APOBEC1
	CLIAs for APOBEC1

Browse ESI BIO Cell Lines and PureStem Progenitors for APOBEC1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOBEC1

	SwitchGear 3'UTR luciferase reporter plasmids for APOBEC1
	SwitchGear Promoter luciferase reporter plasmids for APOBEC1

ThermoFisher Antibody for APOBEC1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOBEC1

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOBEC1
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APOBEC1

LSBio Antibodies in human, mouse, rat for APOBEC1

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes APOBEC1 gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

APOBEC1 Gene

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide...

Aliases
for APOBEC1 gene

Summaries
for APOBEC1 gene

Genomic Views
for APOBEC1 gene

Proteins
for APOBEC1 gene

APOBEC1 Human Recombinant Protein Products:

APOBEC1 Antibody Products:

APOBEC1 Assay Products:

Domains /
Families
for APOBEC1 gene

Function
for APOBEC1 gene

Localization
for APOBEC1 gene

Pathways & Interactions
for APOBEC1 gene

Drugs & Compounds
for APOBEC1 gene

Transcripts
for APOBEC1 gene

Expression
for APOBEC1 gene

Orthologs
for APOBEC1 gene

Paralogs
for APOBEC1 gene

Genomic Variants
for APOBEC1 gene

Disorders / Diseases
for APOBEC1 gene

Publications
for APOBEC1 gene

External Searches for APOBEC1 gene

Genome Databases showing APOBEC1 gene

Other Databases showing APOBEC1 gene

Specialized Databases showing APOBEC1 gene

Intellectual Property
for APOBEC1 gene

Products
for APOBEC1 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

APOBEC1 Gene

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide...

Aliasesfor APOBEC1 gene

Summariesfor APOBEC1 gene

Genomic Viewsfor APOBEC1 gene

Proteinsfor APOBEC1 gene

APOBEC1 Human Recombinant Protein Products:

APOBEC1 Antibody Products:

APOBEC1 Assay Products:

Domains /Familiesfor APOBEC1 gene

Functionfor APOBEC1 gene

Localizationfor APOBEC1 gene

Pathways & Interactionsfor APOBEC1 gene

Drugs & Compoundsfor APOBEC1 gene

Transcriptsfor APOBEC1 gene

Expression for APOBEC1 gene

Orthologsfor APOBEC1 gene

Paralogsfor APOBEC1 gene

Genomic Variantsfor APOBEC1 gene

Disorders / Diseasesfor APOBEC1 gene

Publicationsfor APOBEC1 gene

External Searches for APOBEC1 gene

Genome Databases showing APOBEC1 gene

Other Databases showing APOBEC1 gene

Specialized Databases showing APOBEC1 gene

Intellectual Propertyfor APOBEC1 gene

Productsfor APOBEC1 gene

View Random Gene

Aliases
for APOBEC1 gene

Summaries
for APOBEC1 gene

Genomic Views
for APOBEC1 gene

Proteins
for APOBEC1 gene

Domains /
Families
for APOBEC1 gene

Function
for APOBEC1 gene

Localization
for APOBEC1 gene

Pathways & Interactions
for APOBEC1 gene

Drugs & Compounds
for APOBEC1 gene

Transcripts
for APOBEC1 gene

Expression
for APOBEC1 gene

Orthologs
for APOBEC1 gene

Paralogs
for APOBEC1 gene

Genomic Variants
for APOBEC1 gene

Disorders / Diseases
for APOBEC1 gene

Publications
for APOBEC1 gene

Intellectual Property
for APOBEC1 gene

Products
for APOBEC1 gene