APOA5 Gene
protein-coding GIFtS: 57
GCID: GC11M116660
|
|
apolipoprotein A-V
| |
Aliases
for APOA5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Apolipoprotein A-V1 2 | | APOAV2 | | RAP31 2 3 | | Apo-AV3 | | Apolipoprotein A52 3 | | Apo-AV3 | | Regeneration-Associated Protein 32 3 | | ApoA-V3 | | APOA-V1 | | |
Export aliases for APOA5 gene to outside databasesPrevious GC identifers: GC11M119012 GC11M118172 GC11M116693 GC11M116197 GC11M116165 GC11M112592 |
Summaries
for APOA5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for APOA5:
The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasmatriglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoproteinand is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene havebeen associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to theapolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same proteinhave been identified. (provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: APOA5_HUMAN, Q6Q788Function: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated withchylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CIIlipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting theVLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does notenhance efflux of cholesterol from macrophages
Gene Wiki entry for APOA5
|
Genomic Views
for APOA5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the APOA5 gene promoter:
PPAR-alpha PPAR-gamma1 HNF-4alpha2 PPAR-gamma2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for APOA5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOA5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23APOA5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M116660: view genomic region
(about GC identifiers)
Start:
|
116,660,083 bp from pter |
End:
|
116,663,136 bp from pter |
Size:
|
3,054 bases |
Orientation:
|
minus strand |
|
Proteins
for APOA5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: APOA5_HUMAN, Q6Q788 (See
protein sequence)Recommended Name: Apolipoprotein A-V precursor Size: 366 amino acids; 41213 Da
Subunit: Interacts with GPIHBP1
Subcellular location: Secreted
Miscellaneous: Induced in early phase of liver regeneration
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=AAF25661.1; Type=Erroneous initiation; Sequence=AAF25662.1; Type=Erroneous initiation;Sequence=AAQ89109.1; Type=Erroneous termination; Positions=275; Note=Translated as Gln;
Secondary accessions: B0YIV9 Q3MIK6 Q6UWK9 Q9UBJ3Explore the universe of human proteins at neXtProt for APOA5: NX_Q6Q788
Post-translational modifications:
Phosphorylation sites are present in the extracellular medium1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6Q788
APOA5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001160070.1 NP_443200.2
ENSEMBL proteins: ENSP00000227665 ENSP00000399701 ENSP00000445002 Reactome Protein details: Q6Q788
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
APOA5 for ontologies About GeneDecksing
APOA5 Antibody Products:
Assay Products for APOA5: |
Protein
Domains /
Families
for APOA5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
APOA5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6Q788ProtoNet protein and cluster: Q6Q788 UniProtKB/Swiss-Prot: APOA5_HUMAN, Q6Q788Similarity: Belongs to the apolipoprotein A1/A4/E family |
Function
for APOA5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: APOA5_HUMAN, Q6Q788Function: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated withchylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CIIlipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting theVLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does notenhance efflux of cholesterol from macrophagesInduction: Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOA5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOA5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): APOA5 (NM_001166598) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APOA5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOA5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOA5 |
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table
APOA5 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for APOA5: Apoa5tm1Lap Apoa5tm1Hgc
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Apoa5):
APOA5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for APOA5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | | | 2 | Statin Pathway, Pharmacodynamics | | | 3 | Metabolism | | | 4 | Ca, cAMP and Lipid Signaling | | | 5 | Expression of APOA5 | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for APOA5
1  BioSystems Pathway for APOA5
5/6 
Reactome Pathways for APOA5 (see all 6)
1  PharmGKB Pathway for APOA5
1 
Kegg Pathway (Kegg details for APOA5):
APOA5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APOA5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/20 Interacting proteins for APOA5 (ENSP000002276654) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table
APOA5 for ontologies About GeneDecksing
|
Drugs & Compounds
for APOA5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
APOA5 for compounds About GeneDecksing
 Browse Tocris compounds for APOA5
10/1075 HMDB Compounds for APOA5 (see all 1075) About this table
9 Novoseek chemical compound relationships for APOA5 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cholesterol |
66 |
42 |
19343127 (4), 19150068 (3), 18946207 (2), 16386723 (2) (see all 21) |
| lipid |
63.3 |
75 |
18450648 (7), 17957227 (2), 18652480 (2), 15649902 (2) (see all 39) |
| fenofibrate |
56.7 |
8 |
17431185 (3), 19056598 (2), 12637506 (1), 19344899 (1) |
| triacylglycerol |
50.3 |
26 |
19056598 (3), 15447887 (2), 17401142 (2), 18603531 (1) (see all 9) |
| dimyristoylphosphatidylcholine |
47.5 |
4 |
15878877 (1), 17326667 (1), 12810715 (1) |
| fatty acid |
26 |
2 |
16531749 (1) |
| glucose |
16.8 |
14 |
12697303 (2), 17705673 (2), 19018513 (2), 19303979 (1) (see all 6) |
| cysteine |
0 |
2 |
16046221 (1), 16510431 (1) |
| heparin |
0 |
4 |
17326667 (2), 15878877 (1) |
Search CenterWatch for drugs/clinical trials and news about APOA5
|
Transcripts
for APOA5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for APOA5 gene (2 alternative transcripts): NM_001166598.1 NM_052968.4 Unigene Cluster for APOA5: Apolipoprotein A-V Hs.283923 [show with all ESTs]Unigene Representative Sequence: NM_0529683 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000227665 ENST00000433069 ENST00000542499(uc001ppr.3 uc009yzf.3 uc009yzg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOA5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOA5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): APOA5 (NM_001166598) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APOA5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOA5 |
Additional cDNA sequence: AF202889.1 AF202890.1 AK292739.1 AK308047.1 AK315229.1 AY358749.1 BC101787.1 BC101789.1 2 DOTS entries: DT.91692476 DT.120749905 24/288 AceView cDNA sequences (see all 288): BC011929 BF056026 BM703850 BQ069170 AI198393 BC017349 BM910418 AI417937 BQ651632 AW594693 BF514945 BM917066 BC012162 BU542515 BQ649624 BM695880 BG575759 BU502732 NM_052968 AI650327 BQ674372 CR594434 CR622469 CR621542
GeneLoc Exon Structure
|
Expression
for APOA5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| APOA5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCAGTCCT
About this image
See APOA5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APOA5
SOURCE GeneReport for Unigene cluster: Hs.283923
UniProtKB/Swiss-Prot: APOA5_HUMAN, Q6Q788Tissue specificity: Liver and plasma
SABiosciences Expression via Pathway-Focused PCR Arrays including APOA5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOA5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APOA5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOA5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOA5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOA5 |
Orthologs
for APOA5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for APOA5 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
APOA51 |
apolipoprotein A-V |
59.17(n)
44.09(a) |
|
419802 XM_417939.3 XP_417939.2 |
ENSEMBL Gene Tree for APOA5 (if available)
TreeFam Gene Tree for APOA5 (if available) |
Paralogs
for APOA5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for APOA5 gene
- APOE2 APOA12 APOA42
APOA5 for paralogs About GeneDecksing
|
Genomic Variants
for APOA5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: APOA5_HUMAN, Q6Q788Polymorphism: Three common alleles are known: allele APOA5*1, APOA5*2 and APOA5*3. The APOA5*2 haplotype, whichconsists of 3 non-coding SNPs, is present in approximately 16% of Caucasians and is associated with increased plasmatriglyceride concentrations. APOA5*3 haplotype is defined by the rare Ser-19-Trp substitution. Together, the APOA5*2and APOA5*3 haplotypes are found in 25 to 50% of African Americans, Hispanics, and Caucasians
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for APOA5 (116660083 - 116663136 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for APOA5
1 CNV: 34918
Human Gene Mutation Database (HGMD): APOA5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOA5 |
|
Disorders
/ Diseases
for APOA5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
APOA5 for disorders About GeneDecksing
OMIM gene information: 606368
OMIM disorders: 145750 144650
UniProtKB/Swiss-Prot: APOA5_HUMAN, Q6Q788
Defects in APOA5 are a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750].mFamilialhypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL)is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis Defects in APOA5 are a cause of hyperlipoproteinemia type 5 (HLPP5) [MIM:144650]. HLPP5 is characterized byincreased amounts of chylomicrons and very low density lipoprotein (VLDL) and decreased low density lipoprotein (LDL)and high density lipoprotein (HDL) in the plasma after a fast. Numerous conditions cause this phenotype, includinginsulin-dependent diabetes mellitus, contraceptive steroids, alcohol abuse, and glycogen storage disease type 1A(GSD1A) [MIM:232200]
20/34  diseases for APOA5 (see all 34): About MalaCardshypertriglyceridemia hyperlipoproteinemia hyperlipoproteinemia type iii glycogen storage disease type 1a
glycogen storage disease patent ductus arteriosus familial combined hyperlipidemia type 2 diabetes mellitus
coronary heart disease myocardial infarction hyperlipidemia diabetes mellitus
alcohol abuse acute myocardial infarction familial hypertriglyceridemia familial hyperlipidemia
familial hypercholesterolemia insulin resistance hypercholesterolemia cerebral infarction
2 diseases from the University of Copenhagen DISEASES database for APOA5:Familial hyperlipidemia Coronary heart disease 10/15 Novoseek disease relationships for APOA5 gene (see all 15) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hypertriglyceridemia |
86.4 |
58 |
15591215 (4), 17919884 (3), 16238453 (3), 16125709 (3) (see all 28) |
| hypertriglyceridemias familial |
74.8 |
6 |
16531747 (1), 17483372 (1), 16861622 (1) |
| hyperlipidemia familial combined |
72.9 |
6 |
15774484 (1), 16680034 (1), 14551155 (1), 17157483 (1) |
| endogenous hypertriglyceridemia |
70.9 |
4 |
16200213 (2), 19447388 (1), 15591215 (1) |
| dyslipidemia |
64.7 |
6 |
17700364 (1), 14959997 (1), 16680034 (1), 18658049 (1) (see all 5) |
| hyperlipoproteinemia type iii |
59.5 |
2 |
16143024 (1) |
| cardiovascular diseases |
50.8 |
9 |
15447887 (1), 12637506 (1), 15342688 (1), 15877284 (1) (see all 7) |
| coronary artery disease |
48.1 |
20 |
16769999 (2), 19185864 (2), 15306190 (2), 19159622 (2) (see all 12) |
| coronary heart disease |
47 |
7 |
14729863 (2), 20452521 (1), 15877284 (1), 17356049 (1) (see all 5) |
| atherosclerosis |
32.8 |
2 |
18579034 (1), 17635078 (1) |
Genetic Association Database (GAD): APOA5
Human Genome Epidemiology (HuGE) Navigator: APOA5 (205 documents)
Export disorders for APOA5 gene to outside databases
|
Publications
for APOA5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for APOA5 gene, integrated from 9 sources (see all 343):
(articles sorted by number of sources associating them with APOA5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. (PubMed id 12417524)1, 2, 4, 9 Pennacchio L.A....Cohen J.C. (2002)
- An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. (PubMed id 11588264)1, 2, 3, 9 Pennacchio L.A.... Rubin E.M. (2001)
- A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia. (PubMed id 12915450)1, 2, 4, 9 Kao J.-T.... Lin S.-W. (2003)
- Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. (PubMed id 11577099)1, 2, 3 van der Vliet H.N....Chamuleau R.A. (2001)
- Structure and interfacial properties of human apolipoprotein A-V. (PubMed id 12810715)1, 2, 9 Weinberg R.B.... Ryan R.O. (2003)
- The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins. (PubMed id 15528295)1, 2, 9 O'Brien P.J.... Konrad R.J. (2005)
- APOA5 gene polymorphism modulates levels of triglyceride, HDL cholesterol and FERHDL but is not a risk factor for coronary artery disease. (PubMed id 15306190)1, 4, 9 Lee K.W....Hill J.S. (2004)
- Genetic variants in Apolipoprotein AV alter triglyceride concentrations in pregnancy. (PubMed id 14613578)1, 4, 9 Ward K.J....Frayling T.M. (2003)
- Impact of apolipoprotein A5 polymorphisms on insulin sensitivity and beta-cell function. (PubMed id 15841042)1, 4, 9 Chiu K.C....Chuang L.M. (2005)
- The single nucleotide polymorphism -1131T>C in the apolipoprotein A5 (APOA5) gene is associated with elevated triglycerides in patients with hyperlipidemia. (PubMed id 12937897)1, 4, 9 Evans D....Beil F.U. (2003)
|
External Searches for APOA5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing APOA5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing APOA5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing APOA5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for APOA5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for APOA5 gene:
Search GeneIP for patents involving APOA5
Licensable Technologies for APOA5 gene:GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for APOA5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for APOA5 | | OriGene shRNA RFP for APOA5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOA5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOA5 | | | OriGene Protein Over-expression Lysate for APOA5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for APOA5 | | OriGene 3'-UTR Clone for APOA5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOA5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOA5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for APOA5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for APOA5 | | OriGene Custom Protein Services for APOA5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APOA5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOA5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOA5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOA5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOA5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOA5 |
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| | Antibodies & Assays for APOA5 |
| | | | Search Tocris compounds for APOA5 |
| |  |  |  |  | | | | | | Recombinant Protein for APOA5 |
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 | | | APOA5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOA5 |
|  |  |  | | | | ThermoFisher Antibodies for APOA5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOA5 |
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