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Aliases for APOA5 Gene

Aliases for APOA5 Gene

  • Apolipoprotein A-V 2 3
  • Regeneration-Associated Protein 3 3 4
  • Apolipoprotein A5 3 4
  • Apo-AV 3 4
  • RAP3 3 4
  • Apolipoprotein A-V Precursor Variant 3 3
  • ApoA-V 4
  • APOAV 3

External Ids for APOA5 Gene

Previous GeneCards Identifiers for APOA5 Gene

  • GC11M119012
  • GC11M118172
  • GC11M116693
  • GC11M116197
  • GC11M116165
  • GC11M116660
  • GC11M112592

Summaries for APOA5 Gene

Entrez Gene Summary for APOA5 Gene

  • The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

GeneCards Summary for APOA5 Gene

APOA5 (Apolipoprotein A-V) is a Protein Coding gene. Diseases associated with APOA5 include hypertriglyceridemia and hyperchylomicronemia, late-onset. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include enzyme binding and heparin binding.

UniProtKB/Swiss-Prot for APOA5 Gene

  • Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.

Gene Wiki entry for APOA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA5 Gene

Genomics for APOA5 Gene

Regulatory Elements for APOA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APOA5 Gene

Chromosome:
11
Start:
116,789,367 bp from pter
End:
116,792,420 bp from pter
Size:
3,054 bases
Orientation:
Minus strand

Genomic View for APOA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA5 Gene

Proteins for APOA5 Gene

  • Protein details for APOA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6Q788-APOA5_HUMAN
    Recommended name:
    Apolipoprotein A-V
    Protein Accession:
    Q6Q788
    Secondary Accessions:
    • B0YIV9
    • Q3MIK6
    • Q6UWK9
    • Q9UBJ3

    Protein attributes for APOA5 Gene

    Size:
    366 amino acids
    Molecular mass:
    41213 Da
    Quaternary structure:
    • Interacts with GPIHBP1.
    Miscellaneous:
    • Induced in early phase of liver regeneration
    SequenceCaution:
    • Sequence=AAF25661.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF25662.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89109.1; Type=Erroneous termination; Positions=275; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for APOA5 Gene

Proteomics data for APOA5 Gene at MOPED

Post-translational modifications for APOA5 Gene

Other Protein References for APOA5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for APOA5 (APOA5)

No data available for DME Specific Peptides for APOA5 Gene

Domains & Families for APOA5 Gene

Gene Families for APOA5 Gene

Protein Domains for APOA5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6Q788

UniProtKB/Swiss-Prot:

APOA5_HUMAN :
  • Belongs to the apolipoprotein A1/A4/E family.
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOA5: view

Function for APOA5 Gene

Molecular function for APOA5 Gene

UniProtKB/Swiss-Prot Function:
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
UniProtKB/Swiss-Prot Induction:
Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates).

Gene Ontology (GO) - Molecular Function for APOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding IDA 12810715
GO:0008047 enzyme activator activity IDA 16806135
GO:0008201 heparin binding IDA 15878877
GO:0008289 lipid binding IDA 12810715
GO:0015485 cholesterol binding IBA --
genes like me logo Genes that share ontologies with APOA5: view

Phenotypes for APOA5 Gene

genes like me logo Genes that share phenotypes with APOA5: view

Animal Models for APOA5 Gene

MGI Knock Outs for APOA5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for APOA5 Gene

Localization for APOA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA5 Gene COMPARTMENTS Subcellular localization image for APOA5 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for APOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 18635818
GO:0034361 very-low-density lipoprotein particle IDA 15528295
GO:0034362 NOT low-density lipoprotein particle IDA 15528295
GO:0034364 high-density lipoprotein particle IDA 15528295
genes like me logo Genes that share ontologies with APOA5: view

Pathways & Interactions for APOA5 Gene

genes like me logo Genes that share pathways with APOA5: view

Pathways by source for APOA5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for APOA5 Gene

Gene Ontology (GO) - Biological Process for APOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006641 triglyceride metabolic process IMP 12417525
GO:0006695 cholesterol biosynthetic process IBA --
GO:0006869 lipid transport IDA 15178420
GO:0009725 response to hormone IEA --
GO:0010873 positive regulation of cholesterol esterification IBA --
genes like me logo Genes that share ontologies with APOA5: view

No data available for SIGNOR curated interactions for APOA5 Gene

Drugs & Compounds for APOA5 Gene

(7) Drugs for APOA5 Gene - From: NovoSeek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 56
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 482
Fenofibrate Approved Pharma PPARalpha agonist 158
Heparin Approved, Investigational Pharma Antagonist 672,226

(10) Additional Compounds for APOA5 Gene - From: HMDB and NovoSeek