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Aliases for APOA5 Gene

Aliases for APOA5 Gene

  • Apolipoprotein A5 2 3 4
  • Regeneration-Associated Protein 3 3 4
  • Apolipoprotein A-V 2 5
  • Apo-AV 3 4
  • RAP3 3 4
  • Apolipoprotein A-V Precursor Variant 3 3
  • ApoA-V 4
  • APOAV 3

External Ids for APOA5 Gene

Previous GeneCards Identifiers for APOA5 Gene

  • GC11M119012
  • GC11M118172
  • GC11M116693
  • GC11M116197
  • GC11M116165
  • GC11M116660
  • GC11M112592

Summaries for APOA5 Gene

Entrez Gene Summary for APOA5 Gene

  • The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

GeneCards Summary for APOA5 Gene

APOA5 (Apolipoprotein A5) is a Protein Coding gene. Diseases associated with APOA5 include Hyperchylomicronemia, Late-Onset and Hypertriglyceridemia. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Ca, cAMP and Lipid Signaling. GO annotations related to this gene include enzyme binding and heparin binding.

UniProtKB/Swiss-Prot for APOA5 Gene

  • Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.

Gene Wiki entry for APOA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA5 Gene

Genomics for APOA5 Gene

Regulatory Elements for APOA5 Gene

Enhancers for APOA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APOA5 on UCSC Golden Path with GeneCards custom track

Promoters for APOA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOA5 Gene

Chromosome:
11
Start:
116,789,367 bp from pter
End:
116,792,420 bp from pter
Size:
3,054 bases
Orientation:
Minus strand

Genomic View for APOA5 Gene

Genes around APOA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA5 Gene

Proteins for APOA5 Gene

  • Protein details for APOA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6Q788-APOA5_HUMAN
    Recommended name:
    Apolipoprotein A-V
    Protein Accession:
    Q6Q788
    Secondary Accessions:
    • B0YIV9
    • Q3MIK6
    • Q6UWK9
    • Q9UBJ3

    Protein attributes for APOA5 Gene

    Size:
    366 amino acids
    Molecular mass:
    41213 Da
    Quaternary structure:
    • Interacts with GPIHBP1.
    Miscellaneous:
    • Induced in early phase of liver regeneration.
    SequenceCaution:
    • Sequence=AAF25661.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF25662.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89109.1; Type=Erroneous termination; Positions=275; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for APOA5 Gene

Proteomics data for APOA5 Gene at MOPED

Post-translational modifications for APOA5 Gene

Other Protein References for APOA5 Gene

No data available for DME Specific Peptides for APOA5 Gene

Domains & Families for APOA5 Gene

Gene Families for APOA5 Gene

Protein Domains for APOA5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6Q788

UniProtKB/Swiss-Prot:

APOA5_HUMAN :
  • Belongs to the apolipoprotein A1/A4/E family.
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOA5: view

Function for APOA5 Gene

Molecular function for APOA5 Gene

UniProtKB/Swiss-Prot Function:
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
UniProtKB/Swiss-Prot Induction:
Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates).

Gene Ontology (GO) - Molecular Function for APOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA,IDA 12810715
GO:0017127 cholesterol transporter activity IBA --
genes like me logo Genes that share ontologies with APOA5: view
genes like me logo Genes that share phenotypes with APOA5: view

Human Phenotype Ontology for APOA5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for APOA5 Gene

MGI Knock Outs for APOA5:

Animal Model Products

  • Taconic Biosciences Mouse Models for APOA5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for APOA5 Gene

Localization for APOA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA5 Gene COMPARTMENTS Subcellular localization image for APOA5 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for APOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042627 chylomicron IDA 15528295
genes like me logo Genes that share ontologies with APOA5: view

Pathways & Interactions for APOA5 Gene

genes like me logo Genes that share pathways with APOA5: view

Pathways by source for APOA5 Gene

1 PharmGKB pathway for APOA5 Gene
1 KEGG pathway for APOA5 Gene

Interacting Proteins for APOA5 Gene

Gene Ontology (GO) - Biological Process for APOA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006641 triglyceride metabolic process IEA,IMP 12417525
GO:0006869 lipid transport IEA,IDA 15178420
GO:0030300 regulation of intestinal cholesterol absorption IBA --
GO:0033700 phospholipid efflux IBA --
GO:0034370 triglyceride-rich lipoprotein particle remodeling IEA --
genes like me logo Genes that share ontologies with APOA5: view

No data available for SIGNOR curated interactions for APOA5 Gene

Drugs & Compounds for APOA5 Gene

(7) Drugs for APOA5 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor 59
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 499

(10) Additional Compounds for APOA5 Gene - From: HMDB and Novoseek