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APOA4 Gene

protein-coding   GIFtS: 58
GCID: GC11M116692

Apolipoprotein A-IV

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein A-IV1 2
Apolipoprotein A42 3
apo-AIV2
apoA-IV2
Apo-AIV3
ApoA-IV3

External Ids:    HGNC: 6021   Entrez Gene: 3372   Ensembl: ENSG000001102447   OMIM: 1076905   UniProtKB: P067273   

Export aliases for APOA4 gene to outside databases

Previous GC identifers: GC11M119044 GC11M118203 GC11M116725 GC11M116229 GC22P9A0027 GC11M116198 GC11M112623


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOA4 Gene:
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been
identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which
after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with
chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of
lecithin-cholesterol acyltransferase in vitro. (provided by RefSeq, Jul 2008)

GeneCards Summary for APOA4 Gene:
APOA4 (apolipoprotein A-IV) is a protein-coding gene. Diseases associated with APOA4 include coronary heart disease, and familial combined hyperlipidemia. GO annotations related to this gene include copper ion binding and protein homodimerization activity. An important paralog of this gene is APOA1.

UniProtKB/Swiss-Prot: APOA4_HUMAN, P06727
Function: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of
lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons

Gene Wiki entry for APOA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOA4 gene promoter:
         COUP-TF1   PPAR-gamma1   COUP-TF   COUP   PPAR-gamma2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOA4 promoter sequence
   Search Chromatin IP Primers for APOA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

APOA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOA4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M116692:  view genomic region     (about GC identifiers)

Start:
116,691,418 bp from pter      End:
116,694,022 bp from pter
Size:
2,605 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APOA4_HUMAN, P06727 (See protein sequence)
Recommended Name: Apolipoprotein A-IV precursor  
Size: 396 amino acids; 45399 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for APOA4:
3S84 (3D)    
Secondary accessions: A8MSL6 Q14CW8 Q6Q787

Explore the universe of human proteins at neXtProt for APOA4: NX_P06727

Explore proteomics data for APOA4 at MOPED

Post-translational modifications: 

  • Phosphorylation sites are present in the extracellular medium1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See APOA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000473.2  
    ENSEMBL proteins: 
     ENSP00000350425  
    Reactome Protein details: P06727

    APOA4 Human Recombinant Protein Products:

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    APOA4 Antibody Products:

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    Cloud-Clone Corp. CLIAs for APOA4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    APOLIPO: Apolipoproteins

    1 InterPro protein domain:
     IPR000074 ApoA1_A4_E

    Graphical View of Domain Structure for InterPro Entry P06727

    ProtoNet protein and cluster: P06727

    1 Blocks protein domain: IPB000074 Apolipoprotein A1/A4/E

    UniProtKB/Swiss-Prot: APOA4_HUMAN, P06727
    Domain: Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B,
    related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices
    are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase
    (LCAT) activating abilities
    Similarity: Belongs to the apolipoprotein A1/A4/E family


    APOA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOA4_HUMAN, P06727
    Function: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of
    lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons

         Genatlas biochemistry entry for APOA4:
    apolipoprotein A-IV,major component of HDL and chylomicrons,involved in the catabolism of chylomicrons and VLDL

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005319lipid transporter activity TAS3080432
    GO:0005507copper ion binding IDA16945374
    GO:0008289lipid binding IMP16159879
    GO:0016209antioxidant activity IDA16945374
    GO:0017127cholesterol transporter activity IDA1935934
         
    APOA4 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Apoa4):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system  other 

    APOA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for APOA4: Apoa4tm1Bres Apoa1/Apoc3/Apoa4Apoa1/Apoc3/tm1Hmez

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOA4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APOA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOA4

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate APOA4:
    hsa-miR-4298 hsa-miR-3122 hsa-miR-1302 hsa-miR-3913-5p hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidAPOA4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat APOA4

    Gene Editing
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    Sino Biological Human cDNA Clone for APOA4
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APOA4_HUMAN, P06727: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    endoplasmic reticulum4
    endosome4
    cytoskeleton3
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA1935934
    GO:0005769early endosome TAS--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005829cytosol TAS--

    APOA4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APOA4 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Statin Pathway
    Statin Pathway0.73
    Statin Pathway, Pharmacodynamics0.73
    2Lipoprotein metabolism
    Lipoprotein metabolism0.59
    Chylomicron-mediated lipid transport0.00
    Lipid digestion, mobilization, and transport0.59
    3Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    Retinoid metabolism and transport0.44
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5RNA Polymerase I Promoter Opening
    Amyloids0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for APOA4
        Ca, cAMP and Lipid Signaling

    1 GeneGo (Thomson Reuters) Pathway for APOA4
        Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)

    1 BioSystems Pathway for APOA4
        Statin Pathway


    3 Reactome Pathways for APOA4
        Amyloids
    Retinoid metabolism and transport
    Chylomicron-mediated lipid transport

    1 PharmGKB Pathway for APOA4
        Statin Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for APOA4):
        Fat digestion and absorption
    Vitamin digestion and absorption


    APOA4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including APOA4: 
              Obesity in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for APOA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for APOA4 (P067273 ENSP000003504254) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    APCSENSP000002550404STRING: ENSP00000255040
    APOA1ENSP000002368504STRING: ENSP00000236850
    APOA2ENSP000003569694STRING: ENSP00000356969
    APOA5ENSP000002276654STRING: ENSP00000227665
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0002227innate immune response in mucosa IDA15254593
    GO:0006869lipid transport IDA1935934
    GO:0006982response to lipid hydroperoxide IDA16945374
    GO:0007159leukocyte cell-cell adhesion IDA15254593

    APOA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOA4

    Selected Novoseek inferred chemical compound relationships for APOA4 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 70 121 10634815 (7), 7956623 (4), 8971092 (3), 15311933 (3) (see all 47)
    lipid 67.2 107 16159879 (5), 15621069 (3), 1811553 (3), 11506989 (3) (see all 62)
    enterostatin 63.5 1 10657520 (1)
    cholesterol ester 49.6 7 15864114 (1), 10729389 (1), 15955471 (1), 11952809 (1) (see all 5)
    xbai 48.4 11 7820939 (1), 9571626 (1), 1678604 (1), 1740321 (1)
    triacylglycerol 44.4 11 16338933 (6), 11058717 (1)
    mspi 35.3 6 9571626 (1), 1678604 (1)
    glutamine 32.5 9 1427020 (1), 1358994 (1), 10729389 (1), 2351649 (1) (see all 7)
    fatty acid 26.1 8 7784143 (1), 7485501 (1), 10729389 (1), 12771323 (1) (see all 7)
    histidine 26 9 1427020 (1), 1358994 (1), 10729389 (1), 2351649 (1) (see all 7)

    1 PharmGKB related drug/compound annotation for APOA4 gene    About this table
    Drug/compound PharmGKB Annotation
    ritonavirCA  



    APOA4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for APOA4 gene: 
    NM_000482.3  

    Unigene Cluster for APOA4:

    Apolipoprotein A-IV
    Hs.1247  [show with all ESTs]
    Unigene Representative Sequence: NM_000482
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357780(uc001pps.1)
    miRNA
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    hsa-miR-4298 hsa-miR-3122 hsa-miR-1302 hsa-miR-3913-5p hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidAPOA4 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat APOA4

    Additional mRNA sequence: 

    BC074764.2 BC113594.1 BC113596.1 M10373.1 M13654.1 M14566.1 X13629.1 

    1 DOTS entry:

    DT.310913 

    23 AceView cDNA sequences:

    AI791957 X13629 BC074764 AL532533 M10373 BV183230 NM_000482 BX406671 
    BQ083673 BX325063 BM825700 BX410178 M14566 AL531739 M13654 AW192684 
    BX325065 BX406670 BX422643 AA588783 AL564153 BX387982 AU076799 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAGTGGGA
    APOA4 Expression
    About this image


    APOA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Periportal Hepatocytes Liver Lobule
             Hepatocyte-like cells
    APOA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1247

    UniProtKB/Swiss-Prot: APOA4_HUMAN, P06727
    Tissue specificity: Synthesized primarily in the intestine and secreted in plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including APOA4: 
              Obesity in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for APOA4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for APOA4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apoa41 , 5 apolipoprotein A-IV1, 5 75.2(n)1
    61.19(a)1
      9 (25.36 cM)5
    118081  NM_007468.21  NP_031494.21 
     462406965 
    chicken
    (Gallus gallus)
    Aves APOA41 apolipoprotein A-IV 65.75(n)
    52.21(a)
      395780  NM_204938.1  NP_990269.1 
    lizard
    (Anolis carolinensis)
    Reptilia APOA46
    apolipoprotein A-IV
    49(a)
    1 ↔ 1
    GL343949.1(68211-70358)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia apoa41 apolipoprotein A4 54.21(n)
    41.29(a)
      493461  NM_001008098.2  NP_001008099.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-7f3.151 si:dkey-7f3.15 51.29(n)
    32.76(a)
      100004607  XM_001338001.4  XP_001338037.1 


    ENSEMBL Gene Tree for APOA4 (if available)
    TreeFam Gene Tree for APOA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APOA4 gene
    APOA12  

    APOA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    APOA4_HUMAN, P06727: Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%),
    APOA-IV*2 is also common (8%), the others are rare alleles. The sequence shown represents allele APOA-IV*1


    Selected SNPs for APOA4 (see all 216)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs51101,2,,4
    C,F,Hnon-pathogenic1116555408(-) CAGCAG/TCAGGA 2 Q H mis119Minor allele frequency- T:0.05MN NS EA NA 7302
    rs1219095761,2
    Cpathogenic1116555800(-) ACGCCA/GAGGAG 2 K E mis10--------
    rs352116091,2
    C--112623784(+) TTTGG-/GACA  
            
    GACAG
    1 -- ut310--------
    rs127210391,2
    F--112623797(+) GACAG-/A/ACAG
            
    CAGGT
    2 -- ut31 cds11--144
    rs1888860681,2
    --116554817(+) GCCAGC/GGACCC 1 -- ds50010--------
    rs1132876871,2
    C--116554853(+) CCTCAA/GTGTGA 1 -- ds50010--------
    rs1930997161,2
    --116554881(+) GGCTGA/CACAAA 1 -- ds50010--------
    rs1842318841,2
    --116554906(+) TGTCCA/GGTGCC 1 -- ds50010--------
    rs1867566351,2
    --116554933(+) GCATCA/GGAGGC 1 -- ds50010--------
    rs127210401,2
    C,F--116555258(+) GACATG/ATGTCC 1 -- ut31 ese33Minor allele frequency- A:0.01NS 330

    HapMap Linkage Disequilibrium report for APOA4 (116691418 - 116694022 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for APOA4: --
    Human Gene Mutation Database (HGMD): APOA4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOA4
    DNA2.0 Custom Variant and Variant Library Synthesis for APOA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107690    OMIM disorders: --

    Selected diseases for APOA4 (see all 54):    
    About MalaCards
    coronary heart disease    familial combined hyperlipidemia    familial hypercholesterolemia    proteinuria
    chronic inflammatory demyelinating polyneuropathy    ischemic heart disease    hyperglycemia    venous thromboembolism
    hypercholesterolemia    hypertriglyceridemia    patent ductus arteriosus    coronary artery disease
    demyelinating polyneuropathy    gigantism    morbid obesity    proliferative diabetic retinopathy
    cerebrovascular disease    amyloidosis    thromboembolism    type 1 diabetes mellitus


    APOA4 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for APOA4 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 48 25 11031214 (2), 8688083 (2), 16770585 (2), 9925658 (2) (see all 14)
    hypertriglyceridemia 43 4 7621979 (1), 11031214 (1), 7897325 (1), 7956623 (1)
    coronary heart disease 42 4 8427859 (2), 15175360 (1), 9013087 (1)
    hyperlipidemia familial combined 37.9 2 8956036 (1), 11583715 (1)
    hypercholesterolemia familial 33.8 2 9714133 (2)
    obesity 26.4 18 15621069 (2), 15356672 (2), 14669151 (2), 12731292 (1) (see all 10)
    amyloidosis systemic 25.4 3 15146166 (2)
    cardiovascular diseases 25.1 4 12694323 (1), 7980697 (1), 18948973 (1)
    coronary artery disease 21.6 7 12777472 (2), 10987595 (1), 8102653 (1), 11805176 (1)
    coronary atherosclerosis 15.6 1 17991756 (1)

    Genetic Association Database (GAD): APOA4
    Human Genome Epidemiology (HuGE) Navigator: APOA4 (92 documents)

    Export disorders for APOA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOA4 gene, integrated from 10 sources (see all 401):
    (articles sorted by number of sources associating them with APOA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A- I-containing lipoproteins in a normal population. (PubMed id 1349197)1, 2, 4, 9 von Eckardstein A....Assmann G. (Am. J. Hum. Genet. 1992)
    2. A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127. (PubMed id 1737067)1, 2, 9 Tenkanen H.... Ehnholm C. (Biochim. Biophys. Acta 1992)
    3. Distribution and effect of apo A-IV genotype on plasma lipid and apolipoprotein levels in a Chinese population. (PubMed id 18664021)1, 4, 9 Bai H....Liu B.W. (Acta Cardiol 2008)
    4. The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease. (PubMed id 15175360)1, 4, 9 Wong W.M....Talmud P.J. (J. Lipid Res. 2004)
    5. Two polymorphisms in the apo A-IV gene and familial combined hyperlipidemia. (PubMed id 11583715)1, 4, 9 Groenendijk M....Dallinga-Thie G.M. (Atherosclerosis 2001)
    6. Population genetics of apolipoproteins A-IV, E, and H, and the angiotensin converting enzyme (ACE): associations with lipids, and apolipoprotein levels in American Samoans. (PubMed id 15252864)1, 4, 9 Crews D.E....Kamboh M.I. (Am. J. Phys. Anthropol. 2004)
    7. The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. (PubMed id 12556235)1, 4, 9 Garasto S....De Benedictis G. (Ann. Hum. Genet. 2003)
    8. Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption. (PubMed id 11952809)1, 4, 9 Plat J. and Mensink R.P. (Eur. J. Clin. Invest. 2002)
    9. The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes. (PubMed id 16770585)1, 4, 9 Kretowski A....Rewers M. (Diabetologia 2006)
    10. Frequencies of apolipoprotein A4 gene polymorphisms and association with serum lipid concentrations in two healthy Spanish populations. (PubMed id 15359534)1, 4, 9 GaA+A!n A....PocovA- M. (Hum. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 337 HGNC: 602 AceView: APOA4 Ensembl:ENSG00000110244 euGenes: HUgn337
    ECgene: APOA4 Kegg: 337 H-InvDB: APOA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for APOA4 Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA4

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APOA4 gene:
    Search GeneIP for patents involving APOA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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