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Aliases for APOA4 Gene

Aliases for APOA4 Gene

  • Apolipoprotein A-IV 2 3
  • Apolipoprotein A4 3 4
  • Apo-AIV 3 4
  • ApoA-IV 3 4

External Ids for APOA4 Gene

Previous GeneCards Identifiers for APOA4 Gene

  • GC11M119044
  • GC11M118203
  • GC11M116725
  • GC11M116229
  • GC22P9A0027
  • GC11M116198
  • GC11M116692
  • GC11M112623

Summaries for APOA4 Gene

Entrez Gene Summary for APOA4 Gene

  • Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOA4 Gene

APOA4 (Apolipoprotein A-IV) is a Protein Coding gene. Diseases associated with APOA4 include chronic inflammatory demyelinating polyneuropathy and demyelinating polyneuropathy. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include protein homodimerization activity and copper ion binding. An important paralog of this gene is APOA1.

UniProtKB/Swiss-Prot for APOA4 Gene

  • May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons

Gene Wiki entry for APOA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA4 Gene

Genomics for APOA4 Gene

Regulatory Elements for APOA4 Gene

Genomic Location for APOA4 Gene

Start:
116,820,700 bp from pter
End:
116,823,306 bp from pter
Size:
2,607 bases
Orientation:
Minus strand

Genomic View for APOA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA4 Gene

Proteins for APOA4 Gene

  • Protein details for APOA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06727-APOA4_HUMAN
    Recommended name:
    Apolipoprotein A-IV
    Protein Accession:
    P06727
    Secondary Accessions:
    • A8MSL6
    • Q14CW8
    • Q6Q787

    Protein attributes for APOA4 Gene

    Size:
    396 amino acids
    Molecular mass:
    45399 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for APOA4 Gene

neXtProt entry for APOA4 Gene

Proteomics data for APOA4 Gene at MOPED

Post-translational modifications for APOA4 Gene

  • Phosphorylation sites are present in the extracellular medium
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOA4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for APOA4 Gene

Domains for APOA4 Gene

Gene Families for APOA4 Gene

HGNC:

Protein Domains for APOA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06727

UniProtKB/Swiss-Prot:

APOA4_HUMAN :
  • P06727
Domain:
  • Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOA4: view

Function for APOA4 Gene

Molecular function for APOA4 Gene

GENATLAS Biochemistry: apolipoprotein A-IV,major component of HDL and chylomicrons,involved in the catabolism of chylomicrons and VLDL
UniProtKB/Swiss-Prot Function: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons

Gene Ontology (GO) - Molecular Function for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity TAS 3080432
GO:0005507 copper ion binding IDA 16945374
GO:0005515 protein binding IPI 24311788
GO:0008289 lipid binding IMP 16159879
GO:0015485 cholesterol binding IBA --
genes like me logo Genes that share ontologies with APOA4: view
genes like me logo Genes that share phenotypes with APOA4: view

Animal Models for APOA4 Gene

MGI Knock Outs for APOA4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for APOA4 Gene

Localization for APOA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA4 Gene COMPARTMENTS Subcellular localization image for APOA4 gene
Compartment Confidence
extracellular 5
cytosol 4
endoplasmic reticulum 4
endosome 4
cytoskeleton 3
nucleus 1

Gene Ontology (GO) - Cellular Components for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 1935934
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with APOA4: view

Pathways for APOA4 Gene

genes like me logo Genes that share pathways with APOA4: view

Pathways by source for APOA4 Gene

1 Cell Signaling Technology pathway for APOA4 Gene
1 BioSystems pathway for APOA4 Gene

Gene Ontology (GO) - Biological Process for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0002227 innate immune response in mucosa IDA 15254593
GO:0006695 cholesterol biosynthetic process IBA --
GO:0006869 lipid transport IDA 1935934
GO:0006982 response to lipid hydroperoxide IDA 16945374
genes like me logo Genes that share ontologies with APOA4: view

Compounds for APOA4 Gene

(27) Novoseek inferred chemical compound relationships for APOA4 Gene

Compound -log(P) Hits PubMed IDs
cholesterol 70 70
lipid 67.2 86
enterostatin 63.5 1
cholesterol ester 49.6 5
xbai 48.4 4

(1) PharmGKB related drug/compound annotations for APOA4 Gene

Drug/compound Annotation
ritonavir CA
genes like me logo Genes that share compounds with APOA4: view

Transcripts for APOA4 Gene

mRNA/cDNA for APOA4 Gene

(7) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOA4 Gene

Apolipoprotein A-IV:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOA4 Gene

No ASD Table

Relevant External Links for APOA4 Gene

GeneLoc Exon Structure for
APOA4
ECgene alternative splicing isoforms for
APOA4

Expression for APOA4 Gene

mRNA expression in normal human tissues for APOA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOA4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (37.5) and Liver (15.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APOA4 Gene

SOURCE GeneReport for Unigene cluster for APOA4 Gene Hs.1247

mRNA Expression by UniProt/SwissProt for APOA4 Gene

P06727-APOA4_HUMAN
Tissue specificity: Synthesized primarily in the intestine and secreted in plasma
genes like me logo Genes that share expressions with APOA4: view

Orthologs for APOA4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOA4 35
  • 99.07 (n)
  • 98.23 (a)
APOA4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOA4 35
  • 84.51 (n)
  • 78.26 (a)
APOA4 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOA4 35
  • 86.12 (n)
  • 81.96 (a)
APOA4 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoa4 35
  • 75.2 (n)
  • 61.19 (a)
Apoa4 16
Apoa4 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APOA4 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apoa4 35
  • 74.84 (n)
  • 62.53 (a)
chicken
(Gallus gallus)
Aves APOA4 35
  • 65.75 (n)
  • 52.21 (a)
APOAIV 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APOA4 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apoa4 35
  • 54.21 (n)
  • 41.29 (a)
zebrafish
(Danio rerio)
Actinopterygii apoa4 36
  • 31 (a)
OneToMany
APOA4 (1 of 4) 36
  • 30 (a)
OneToMany
APOA4 (3 of 4) 36
  • 29 (a)
OneToMany
APOA4 (4 of 4) 36
  • 31 (a)
OneToMany
si:dkey-7f3.15 35
  • 51.29 (n)
  • 32.76 (a)
Species with no ortholog for APOA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOA4 Gene

ENSEMBL:
Gene Tree for APOA4 (if available)
TreeFam:
Gene Tree for APOA4 (if available)

Paralogs for APOA4 Gene

Paralogs for APOA4 Gene

genes like me logo Genes that share paralogs with APOA4: view

Variants for APOA4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for APOA4 Gene

P06727-APOA4_HUMAN
Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles. The sequence shown represents allele APOA-IV*1

Sequence variations from dbSNP and Humsavar for APOA4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs675 - 116,820,959(+) GAGAG(A/C/T)CTTGT reference, missense
rs5089 -- 116,823,625(-) GCCTC(A/G)AGGCA upstream-variant-2KB
rs5090 -- 116,823,339(-) GGAGA(C/G)AGTTT upstream-variant-2KB
rs5091 -- 116,823,289(-) GCAGC(A/G)CAGGT utr-variant-5-prime
rs5092 -- 116,822,748(-) GCCAC(A/G)GTGAT synonymous-codon, reference

Relevant External Links for APOA4 Gene

HapMap Linkage Disequilibrium report
APOA4
Human Gene Mutation Database (HGMD)
APOA4

No data available for Structural Variations from Database of Genomic Variants (DGV) for APOA4 Gene

Disorders for APOA4 Gene

(28) Novoseek inferred disease relationships for APOA4 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 48 18
hypertriglyceridemia 43 4
coronary heart disease 42 4
hyperlipidemia familial combined 37.9 2
hypercholesterolemia familial 33.8 2

Relevant External Links for APOA4

Genetic Association Database (GAD)
APOA4
Human Genome Epidemiology (HuGE) Navigator
APOA4
genes like me logo Genes that share disorders with APOA4: view

No data available for UniProtKB/Swiss-Prot for APOA4 Gene

Publications for APOA4 Gene

  1. Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A- I-containing lipoproteins in a normal population. (PMID: 1349197) von Eckardstein A. … Assmann G. (Am. J. Hum. Genet. 1992) 3 4 23 48
  2. Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism. (PMID: 1487136) Kamboh M.I. … Pollitzer W.S. (Genet. Epidemiol. 1992) 3 4 23
  3. A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127. (PMID: 1737067) Tenkanen H. … Ehnholm C. (Biochim. Biophys. Acta 1992) 3 4 23
  4. Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity. (PMID: 8956036) Deeb S.S. … Brunzell J.D. (Hum. Mutat. 1996) 3 4 23
  5. Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene. (PMID: 2351649) Lohse P. … Brewer H.B. Jr. (J. Biol. Chem. 1990) 3 4 23

Products for APOA4 Gene

Sources for APOA4 Gene

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