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Aliases for APOA4 Gene

Aliases for APOA4 Gene

  • Apolipoprotein A4 2 3 4
  • Apolipoprotein A-IV 2 5
  • Apo-AIV 3 4
  • ApoA-IV 3 4

External Ids for APOA4 Gene

Previous GeneCards Identifiers for APOA4 Gene

  • GC11M119044
  • GC11M118203
  • GC11M116725
  • GC11M116229
  • GC22P9A0027
  • GC11M116198
  • GC11M116692
  • GC11M112623

Summaries for APOA4 Gene

Entrez Gene Summary for APOA4 Gene

  • Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOA4 Gene

APOA4 (Apolipoprotein A4) is a Protein Coding gene. Diseases associated with APOA4 include carotenemia and demyelinating polyneuropathy. Among its related pathways are Signaling by GPCR and Lipoprotein metabolism. GO annotations related to this gene include protein homodimerization activity and copper ion binding. An important paralog of this gene is APOA1.

UniProtKB/Swiss-Prot for APOA4 Gene

  • May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Gene Wiki entry for APOA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA4 Gene

Genomics for APOA4 Gene

Regulatory Elements for APOA4 Gene

Genomic Location for APOA4 Gene

Chromosome:
11
Start:
116,820,700 bp from pter
End:
116,823,306 bp from pter
Size:
2,607 bases
Orientation:
Minus strand

Genomic View for APOA4 Gene

Genes around APOA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA4 Gene

Proteins for APOA4 Gene

  • Protein details for APOA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06727-APOA4_HUMAN
    Recommended name:
    Apolipoprotein A-IV
    Protein Accession:
    P06727
    Secondary Accessions:
    • A8MSL6
    • Q14CW8
    • Q6Q787

    Protein attributes for APOA4 Gene

    Size:
    396 amino acids
    Molecular mass:
    45399 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for APOA4 Gene

neXtProt entry for APOA4 Gene

Proteomics data for APOA4 Gene at MOPED

Post-translational modifications for APOA4 Gene

  • Phosphorylation sites are present in the extracellular medium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for APOA4 (Apolipoprotein A-IV/ApoA4)
  • Cell Signaling Technology (CST) Antibodies for APOA4 (APOA4)

No data available for DME Specific Peptides for APOA4 Gene

Domains & Families for APOA4 Gene

Gene Families for APOA4 Gene

Protein Domains for APOA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06727

UniProtKB/Swiss-Prot:

APOA4_HUMAN :
  • Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
  • Belongs to the apolipoprotein A1/A4/E family.
Domain:
  • Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOA4: view

Function for APOA4 Gene

Molecular function for APOA4 Gene

GENATLAS Biochemistry:
apolipoprotein A-IV,major component of HDL and chylomicrons,involved in the catabolism of chylomicrons and VLDL
UniProtKB/Swiss-Prot Function:
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Gene Ontology (GO) - Molecular Function for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017127 cholesterol transporter activity IDA 1935934
genes like me logo Genes that share ontologies with APOA4: view
genes like me logo Genes that share phenotypes with APOA4: view

Human Phenotype Ontology for APOA4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for APOA4 Gene

MGI Knock Outs for APOA4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for APOA4 Gene

Localization for APOA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA4 Gene COMPARTMENTS Subcellular localization image for APOA4 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
endosome 4
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome TAS --
GO:0005829 cytosol TAS --
GO:0042627 chylomicron IDA 3095477
genes like me logo Genes that share ontologies with APOA4: view

Pathways & Interactions for APOA4 Gene

genes like me logo Genes that share pathways with APOA4: view

Pathways by source for APOA4 Gene

Gene Ontology (GO) - Biological Process for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0002227 innate immune response in mucosa IEA,IDA 15254593
GO:0006869 lipid transport IEA,IDA 1935934
GO:0006982 response to lipid hydroperoxide IDA 16945374
GO:0007603 phototransduction, visible light TAS --
genes like me logo Genes that share ontologies with APOA4: view

No data available for SIGNOR curated interactions for APOA4 Gene

Drugs & Compounds for APOA4 Gene

(10) Drugs for APOA4 Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ritonavir Approved, Investigational Pharma HIV protease inhibitor 850

(20) Additional Compounds for APOA4 Gene - From: Novoseek and HMDB