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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APOA4 Gene

protein-coding GIFtS: 59
GCID: GC11M116692

apolipoprotein A-IV

Explore 51 diseases affiliated with
APOA4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Apolipoprotein A-IV¹ ²
Apolipoprotein A4² ³
Apo-AIV³
ApoA-IV³
Apo-AIV³
ApoA-IV³

External Ids:	HGNC: 602¹	Entrez Gene: 337²	Ensembl: ENSG00000110244⁷	OMIM: 107690⁵	UniProtKB: P06727³

Export aliases for APOA4 gene to outside databases

Previous GC identifers: GC11M119044 GC11M118203 GC11M116725 GC11M116229 GC22P9A0027 GC11M116198 GC11M112623

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOA4:

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in

the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic

processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles.

Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in

vitro. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: APOA4_HUMAN, P06727

Function: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of

lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons

Gene Wiki entry for APOA4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APOA4 gene promoter:
COUP-TF1 PPAR-gamma1 COUP-TF COUP PPAR-gamma2 HNF-4alpha2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOA4 promoter sequence

Search SABiosciences Chromatin IP Primers for APOA4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOA4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

APOA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOA4 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M116692: view genomic region (about GC identifiers)

Start:	116,691,418 bp from pter	End:	116,694,022 bp from pter
Size:	2,605 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APOA4_HUMAN, P06727 (See protein sequence)

Recommended Name: Apolipoprotein A-IV precursor

Size: 396 amino acids; 45399 Da

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for APOA4:

3S84 (3D)

Secondary accessions: A8MSL6 Q14CW8 Q6Q787

Explore the universe of human proteins at neXtProt for APOA4: NX_P06727

Post-translational modifications:

Phosphorylation sites are present in the extracellular medium¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P06727

APOA4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000473.2

ENSEMBL proteins:

ENSP00000350425

Reactome Protein details: P06727
Human Recombinant Protein Products for APOA4:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for APOA4

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	--
GO:0005737	cytoplasm	--	--
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005813	centrosome	--	--

APOA4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for APOA4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

APOA4 for domains About GeneDecksing

2 InterPro domains/families:

IPR000074 ApoA1_A4_E

IPR013326 ApoA

Graphical View of Domain Structure for InterPro Entry P06727

ProtoNet protein and cluster: P06727

1 Blocks protein family: IPB000074 Apolipoprotein A1/A4/E

UniProtKB/Swiss-Prot: APOA4_HUMAN, P06727

Domain: Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B,

related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are

amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT)

activating abilities

Similarity: Belongs to the apolipoprotein A1/A4/E family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: APOA4_HUMAN, P06727

Function: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of

lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons

Genatlas biochemistry entry for APOA4:

apolipoprotein A-IV,major component of HDL and chylomicrons,involved in the catabolism of chylomicrons and VLDL

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005319	lipid transporter activity	TAS	3080432
GO:0005507	copper ion binding	IDA	16945374
GO:0008289	lipid binding	IMP	16159879
GO:0016209	antioxidant activity	IDA	16945374
GO:0017127	cholesterol transporter activity	IDA	1935934

APOA4 for ontologies About GeneDecksing

Phenotypes:
10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Apoa4):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	hematopoietic system
homeostasis/metabolism	immune system	mortality/aging	nervous system	other

APOA4 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for APOA4: Apoa4^tm1Bres Apoa1/Apoc3/Apoa4^{Apoa1/Apoc3/tm1Hmez}

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for APOA4

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOA4
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate APOA4:
		hsa-miR-4298 hsa-miR-3122 hsa-miR-1302 hsa-miR-3913-5p hsa-miR-1324
		SwitchGear 3'UTR luciferase reporter plasmid: APOA4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOA4

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOA4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lipoprotein metabolism

	Lipoprotein metabolism	1.00			Lipid digestion, mobilization, and transport	0.56
	Chylomicron-mediated lipid transport	0.57

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

Amyloid precursor proteins form ordered fibrils

Amyloid precursor proteins form ordered fibrils

1.00

Amyloids

0.43

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Statin Pathway, Pharmacodynamics

Statin Pathway, Pharmacodynamics

1.00

Statin Pathway

0.80

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for APOA4

Ca, cAMP and Lipid Signaling

1 GeneGo (Thomson Reuters) Pathway for APOA4

Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)

1 BioSystems Pathway for APOA4

Statin Pathway

5/12 Reactome Pathways for APOA4 (see all 12)

	Diseases associated with visual transduction
	Metabolism
	Chylomicron-mediated lipid transport
	Visual phototransduction
	Disease

1 PharmGKB Pathway for APOA4

Statin Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for APOA4):

	Fat digestion and absorption
	Vitamin digestion and absorption

APOA4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for APOA4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/34 Interacting proteins for APOA4 (P06727³ ENSP00000350425⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ALB	P02768³, ENSP00000295897⁴	I2D: score=1 STRING: ENSP00000295897
APCS	ENSP00000255040⁴	STRING: ENSP00000255040
APOA1	ENSP00000236850⁴	STRING: ENSP00000236850
APOA2	ENSP00000356969⁴	STRING: ENSP00000356969
APOA5	ENSP00000227665⁴	STRING: ENSP00000227665

About this table

Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002227	innate immune response in mucosa	IDA	15254593
GO:0006629	lipid metabolic process	TAS	--
GO:0006869	lipid transport	IDA	1935934
GO:0006982	response to lipid hydroperoxide	IDA	16945374
GO:0007159	leukocyte cell-cell adhesion	IDA	15254593

APOA4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

APOA4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for APOA4
10/27 Novoseek chemical compound relationships for APOA4 gene (see all 27) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cholesterol	70	121	10634815 (7), 7956623 (4), 8971092 (3), 15311933 (3) (see all 47)
lipid	67.2	107	16159879 (5), 15621069 (3), 1811553 (3), 11506989 (3) (see all 62)
enterostatin	63.5	1	10657520 (1)
cholesterol ester	49.6	7	15864114 (1), 10729389 (1), 15955471 (1), 11952809 (1) (see all 5)
xbai	48.4	11	7820939 (1), 9571626 (1), 1678604 (1), 1740321 (1)
triacylglycerol	44.4	11	16338933 (6), 11058717 (1)
mspi	35.3	6	9571626 (1), 1678604 (1)
glutamine	32.5	9	1427020 (1), 1358994 (1), 10729389 (1), 2351649 (1) (see all 7)
fatty acid	26.1	8	7784143 (1), 7485501 (1), 10729389 (1), 12771323 (1) (see all 7)
histidine	26	9	1427020 (1), 1358994 (1), 10729389 (1), 2351649 (1) (see all 7)

1 PharmGKB related drug/compound annotation for APOA4 gene About this table

Drug/compound	PharmGKB Annotation
ritonavir	CA

Search CenterWatch for drugs/clinical trials and news about APOA4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APOA4 gene:

NM_000482.3

Unigene Cluster for APOA4:

Apolipoprotein A-IV

Hs.1247 [show with all ESTs]

Unigene Representative Sequence: NM_000482

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000357780(uc001pps.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOA4
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate APOA4:
		hsa-miR-4298 hsa-miR-3122 hsa-miR-1302 hsa-miR-3913-5p hsa-miR-1324
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		GenScript: all cDNA clones in your preferred vector: APOA4 (NM_000482)
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Additional cDNA sequence:

BC074764.2 BC113594.1 BC113596.1 M10373.1 M13654.1 M14566.1 X13629.1

1 DOTS entry:

DT.310913

23 AceView cDNA sequences:

AI791957 X13629 BC074764 BX410178 BV183230 AL531739 BX406671 BQ083673

BM825700 AW192684 BX406670 M13654 AL532533 BX422643 M10373 M14566

BX325065 NM_000482 BX325063 AA588783 AL564153 BX387982 AU076799

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APOA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAGTGGGA

About this image

APOA4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Periportal Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Syncytiotrophoblast-like cells (Generation of syncyt...)

See APOA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APOA4

SOURCE GeneReport for Unigene cluster: Hs.1247

UniProtKB/Swiss-Prot: APOA4_HUMAN, P06727

Tissue specificity: Synthesized primarily in the intestine and secreted in plasma

SABiosciences Expression via Pathway-Focused PCR Arrays including APOA4:

Obesity in human mouse rat

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOA4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for APOA4 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	APOA4¹	apolipoprotein A-IV	65.82(n) 52.25(a)		395780 NM_204938.1 NP_990269.1
lizard (Anolis carolinensis)	Reptilia	APOA4⁶	--	49(a)	1 ↔ 1	GL343949.1(68211-70358)
zebrafish (Danio rerio)	Actinopterygii	apoa4¹	apolipoprotein A-IV	51.15(n) 31.9(a)		322543 NM_001079861.1 NP_001073330.1

ENSEMBL Gene Tree for APOA4 (if available)
TreeFam Gene Tree for APOA4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for APOA4 gene

APOE² APOA1² APOA5²

APOA4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: APOA4_HUMAN, P06727

Polymorphism: Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%),

APOA-IV*2 is also common (8%), the others are rare alleles. The sequence shown represents allele APOA-IV*1

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5110^1,2	C,F,H	non-pathogenic	120750110(-)	`CAGCAG/TCAGGA`	2	Q H	mis¹		19		MN NS EA NA	7302
rs113287687^1,2	C	--	112623347(+)	`CCTCAA/GTGTGA`	1	--	ds500¹		0	--	--	--	--
rs12721040^1,2	C,F	--	112623752(+)	`GACATG/ATNNNN`	1	--	ut3¹ ese³		3		NS	330
rs12721042^1,2	C,F	--	112624815(+)	`TTCTTC/ATGCAG`	2	/Q /H	mis¹ ese³		3		NS	336
rs5102^1,2	C,F	--	112624826(-)	`ACGCAG/AGTGAC`	2	/S /G	mis¹ ese³		2		MN NA	4624
rs5098^1,2	C,F	--	112625085(-)	`ACAAAC/GTATGT`	1	--	int¹		6		MN NS	692
rs5097^1,2	F	--	112625347(-)	`AATACG/ATTTCA`	1	--	int¹		1		MN	80
rs5091^1,2	C,F	--	112626277(-)	`GCAGCG/ACAGGT`	1	--	ut5¹ ese³		4		MN NS	398
rs13306180^1,2	C	--	112626486(-)	`CACCAC/TTTCTA`	1	--	us2k¹		0	--	--	--	--
rs7929134^1,2	C	--	112626610(+)	`TGATGA/CCTCGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for APOA4 (116691418 - 116694022 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APOA4: --
Human Gene Mutation Database (HGMD): APOA4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

APOA4 for disorders           About GeneDecksing

OMIM gene information: 107690    OMIM disorders: --

20/51 diseases for APOA4 (see all 51):    About MalaCards

glycogen storage disease type ia glycogen storage disease patent ductus arteriosus diabetes mellitus

familial combined hyperlipidemia cholesterol type 2 diabetes mellitus proliferative diabetic retinopathy

type 1 diabetes mellitus coronary heart disease amyotrophic lateral sclerosis insulin resistance

hyperlipidemia diabetic retinopathy myocardial infarction ischemic heart disease

lateral sclerosis arterial calcification allergic rhinitis hypercholesterolemia

10/28 Novoseek disease relationships for APOA4 gene (see all 28) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerosis	48	25	11031214 (2), 8688083 (2), 16770585 (2), 9925658 (2) (see all 14)
hypertriglyceridemia	43	4	7621979 (1), 11031214 (1), 7897325 (1), 7956623 (1)
coronary heart disease	42	4	8427859 (2), 15175360 (1), 9013087 (1)
hyperlipidemia familial combined	37.9	2	8956036 (1), 11583715 (1)
hypercholesterolemia familial	33.8	2	9714133 (2)
obesity	26.4	18	15621069 (2), 15356672 (2), 14669151 (2), 12731292 (1) (see all 10)
amyloidosis systemic	25.4	3	15146166 (2)
cardiovascular diseases	25.1	4	12694323 (1), 7980697 (1), 18948973 (1)
coronary artery disease	21.6	7	12777472 (2), 10987595 (1), 8102653 (1), 11805176 (1)
coronary atherosclerosis	15.6	1	17991756 (1)

Genetic Association Database (GAD): APOA4
Human Genome Epidemiology (HuGE) Navigator: APOA4 (92 documents)

Export disorders for APOA4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for APOA4 gene, integrated from 9 sources (see all 392):
(articles sorted by number of sources associating them with APOA4)

Utopia: connect your pdf to the dynamic
world of online information

Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A- I-containing lipoproteins in a normal population. (PubMed id 1349197)^{1, 2, 4, 9} von Eckardstein A....Assmann G. (1992)
A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127. (PubMed id 1737067)^{1, 2, 9} Tenkanen H.... Ehnholm C. (1992)
Population genetics of apolipoproteins A-IV, E, and H, and the angiotensin converting enzyme (ACE): associations with lipids, and apolipoprotein levels in American Samoans. (PubMed id 15252864)^{1, 4, 9} Crews D.E....Kamboh M.I. (2004)
The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. (PubMed id 12556235)^{1, 4, 9} Garasto S....De Benedictis G. (2003)
Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption. (PubMed id 11952809)^{1, 4, 9} Plat J. and Mensink R.P. (2002)
Frequencies of apolipoprotein A4 gene polymorphisms and association with serum lipid concentrations in two healthy Spanish populations. (PubMed id 15359534)^{1, 4, 9} Ganan A....Pocovi M. (2004)
Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. (PubMed id 12417525)^{1, 4, 9} Talmud P.J....Humphries S.E. (2002)
APOA1/C3/A4 gene cluster variability and lipid levels in Brazilian children. (PubMed id 15962178)^{1, 4, 9} de Franca E....Hutz M.H. (2005)
Association of the apolipoprotein A-IV: 360 Gln/His polymorphism with cerebrovascular disease, obesity, and depression in a Brazilian elderly population. (PubMed id 15806598)^{1, 4, 9} Ejchel T.F....de Arruda Cardoso Smith M. (2005)
Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia. (PubMed id 16030523)^{1, 4, 9} van Aalst-Cohen E.S....Kastelein J.J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 337	HGNC: 602	AceView: APOA4	Ensembl:ENSG00000110244	euGenes: HUgn337
ECgene: APOA4	Kegg: 337	H-InvDB: APOA4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for APOA4	Pharmacogenomics, SNPs, Pathways
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA4

Intellectual Property for APOA4 gene
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Patent Information for APOA4 gene:
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