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Aliases for APOA4 Gene

Aliases for APOA4 Gene

  • Apolipoprotein A-IV 2 3
  • Apolipoprotein A4 3 4
  • Apo-AIV 3 4
  • ApoA-IV 3 4

External Ids for APOA4 Gene

Previous GeneCards Identifiers for APOA4 Gene

  • GC11M119044
  • GC11M118203
  • GC11M116725
  • GC11M116229
  • GC22P9A0027
  • GC11M116198
  • GC11M116692
  • GC11M112623

Summaries for APOA4 Gene

Entrez Gene Summary for APOA4 Gene

  • Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOA4 Gene

APOA4 (Apolipoprotein A-IV) is a Protein Coding gene. Diseases associated with APOA4 include carotenemia and chronic inflammatory demyelinating polyneuropathy. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include protein homodimerization activity and copper ion binding. An important paralog of this gene is APOA1.

UniProtKB/Swiss-Prot for APOA4 Gene

  • May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons

Gene Wiki entry for APOA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA4 Gene

Genomics for APOA4 Gene

Regulatory Elements for APOA4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APOA4 Gene

Chromosome:
11
Start:
116,820,700 bp from pter
End:
116,823,306 bp from pter
Size:
2,607 bases
Orientation:
Minus strand

Genomic View for APOA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA4 Gene

Proteins for APOA4 Gene

  • Protein details for APOA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06727-APOA4_HUMAN
    Recommended name:
    Apolipoprotein A-IV
    Protein Accession:
    P06727
    Secondary Accessions:
    • A8MSL6
    • Q14CW8
    • Q6Q787

    Protein attributes for APOA4 Gene

    Size:
    396 amino acids
    Molecular mass:
    45399 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for APOA4 Gene

neXtProt entry for APOA4 Gene

Proteomics data for APOA4 Gene at MOPED

Post-translational modifications for APOA4 Gene

  • Phosphorylation sites are present in the extracellular medium
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for APOA4 (Apolipoprotein A-IV/ApoA4)
  • Cell Signaling Technology (CST) Antibodies for APOA4 (APOA4)

No data available for DME Specific Peptides for APOA4 Gene

Domains & Families for APOA4 Gene

Gene Families for APOA4 Gene

Protein Domains for APOA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06727

UniProtKB/Swiss-Prot:

APOA4_HUMAN :
  • Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities
  • Belongs to the apolipoprotein A1/A4/E family.
Domain:
  • Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOA4: view

Function for APOA4 Gene

Molecular function for APOA4 Gene

GENATLAS Biochemistry:
apolipoprotein A-IV,major component of HDL and chylomicrons,involved in the catabolism of chylomicrons and VLDL
UniProtKB/Swiss-Prot Function:
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons

Gene Ontology (GO) - Molecular Function for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity TAS 3080432
GO:0005507 copper ion binding IDA 16945374
GO:0005515 protein binding IPI 24311788
GO:0008289 lipid binding IMP 16159879
GO:0015485 cholesterol binding IBA --
genes like me logo Genes that share ontologies with APOA4: view
genes like me logo Genes that share phenotypes with APOA4: view

Animal Models for APOA4 Gene

MGI Knock Outs for APOA4:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOA4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for APOA4 Gene

Localization for APOA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA4 Gene COMPARTMENTS Subcellular localization image for APOA4 gene
Compartment Confidence
extracellular 5
cytosol 4
endoplasmic reticulum 4
endosome 4
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 1935934
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with APOA4: view

Pathways & Interactions for APOA4 Gene

genes like me logo Genes that share pathways with APOA4: view

Pathways by source for APOA4 Gene

1 Cell Signaling Technology pathway for APOA4 Gene
1 BioSystems pathway for APOA4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0002227 innate immune response in mucosa IDA 15254593
GO:0006695 cholesterol biosynthetic process IBA --
GO:0006869 lipid transport IDA 1935934
GO:0006982 response to lipid hydroperoxide IDA 16945374
genes like me logo Genes that share ontologies with APOA4: view

No data available for SIGNOR curated interactions for APOA4 Gene

Drugs & Compounds for APOA4 Gene

(10) Drugs for APOA4 Gene - From: NovoSeek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ritonavir Approved, Investigational Pharma HIV protease inhibitor 833
Heparin Approved, Investigational Pharma Antagonist 672,226
Vitamin A Approved Nutra 386
cholesterol Experimental Pharma Agonist 0
oleic acid Experimental Pharma Activation, Activator 0

(20) Additional Compounds for APOA4 Gene - From: NovoSeek and HMDB