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Aliases for APOA4 Gene

Aliases for APOA4 Gene

  • Apolipoprotein A4 2 3 4 5
  • Apolipoprotein A-IV 2 3
  • Apo-AIV 3 4
  • ApoA-IV 3 4

External Ids for APOA4 Gene

Previous GeneCards Identifiers for APOA4 Gene

  • GC11M119044
  • GC11M118203
  • GC11M116725
  • GC11M116229
  • GC22P9A0027
  • GC11M116198
  • GC11M116692
  • GC11M112623

Summaries for APOA4 Gene

Entrez Gene Summary for APOA4 Gene

  • Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOA4 Gene

APOA4 (Apolipoprotein A4) is a Protein Coding gene. Diseases associated with APOA4 include Carotenemia and Demyelinating Polyneuropathy. Among its related pathways are Metabolism of fat-soluble vitamins and Statin Pathway. GO annotations related to this gene include protein homodimerization activity and copper ion binding. An important paralog of this gene is APOA1.

UniProtKB/Swiss-Prot for APOA4 Gene

  • May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Gene Wiki entry for APOA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA4 Gene

Genomics for APOA4 Gene

Regulatory Elements for APOA4 Gene

Enhancers for APOA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F116851 1.2 FANTOM5 Ensembl ENCODE 12.3 -30.2 -30152 4.9 HDGF WRNIP1 FEZF1 KLF7 FOS YY2 JUNB TSHZ1 ZNF488 TBX21 LOC653303 SIK3 APOA1 APOC3 APOA4 ENSG00000236267 APOA5 ZPR1 ENSG00000224077 LOC105369514
GH11F116860 0.4 ENCODE 12.2 -38.3 -38347 1.8 CTCF PKNOX1 CBX3 JUN ARID4B ZIC2 RAD21 TEAD3 EED ZNF143 APOA1 LOC653303 APOA1-AS APOC3 APOA4 ENSG00000224077 SIK3 APOA5 ZPR1 PCSK7
GH11F116863 0.2 ENCODE 11.9 -42.7 -42738 4.2 CTCF ZNF7 APOA1 LOC653303 APOA1-AS APOC3 APOA4 ENSG00000224077 SIK3 APOA5 ZPR1 PCSK7
GH11F116885 0.8 Ensembl ENCODE 11.7 -63.0 -62967 1.5 APOA1 LOC653303 APOA1-AS APOC3 APOA4 ENSG00000224077 SIK3 BUD13 LOC105369514 PCSK7
GH11F116887 0.7 Ensembl ENCODE 11.7 -65.2 -65165 2.2 CEBPA RCOR2 RAD21 LOC653303 APOA1 APOA1-AS APOC3 APOA4 SIK3 ENSG00000224077 ENSG00000254678 PAFAH1B2 APOA5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around APOA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOA4 Gene

Chromosome:
11
Start:
116,820,700 bp from pter
End:
116,823,306 bp from pter
Size:
2,607 bases
Orientation:
Minus strand

Genomic View for APOA4 Gene

Genes around APOA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA4 Gene

Proteins for APOA4 Gene

  • Protein details for APOA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06727-APOA4_HUMAN
    Recommended name:
    Apolipoprotein A-IV
    Protein Accession:
    P06727
    Secondary Accessions:
    • A8MSL6
    • Q14CW8
    • Q6Q787

    Protein attributes for APOA4 Gene

    Size:
    396 amino acids
    Molecular mass:
    45399 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for APOA4 Gene

neXtProt entry for APOA4 Gene

Post-translational modifications for APOA4 Gene

  • Phosphorylation sites are present in the extracellular medium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for APOA4 (Apolipoprotein A-IV/ApoA4)
  • Cell Signaling Technology (CST) Antibodies for APOA4 (APOA4)
  • Santa Cruz Biotechnology (SCBT) Antibodies for APOA4

No data available for DME Specific Peptides for APOA4 Gene

Domains & Families for APOA4 Gene

Gene Families for APOA4 Gene

Protein Domains for APOA4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06727

UniProtKB/Swiss-Prot:

APOA4_HUMAN :
  • Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
  • Belongs to the apolipoprotein A1/A4/E family.
Domain:
  • Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOA4: view

Function for APOA4 Gene

Molecular function for APOA4 Gene

GENATLAS Biochemistry:
apolipoprotein A-IV,major component of HDL and chylomicrons,involved in the catabolism of chylomicrons and VLDL
UniProtKB/Swiss-Prot Function:
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Gene Ontology (GO) - Molecular Function for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity TAS 3080432
GO:0005507 copper ion binding IDA 16945374
GO:0005515 protein binding IPI 24311788
GO:0008289 lipid binding IEA,IMP 16159879
GO:0015485 cholesterol binding IBA --
genes like me logo Genes that share ontologies with APOA4: view
genes like me logo Genes that share phenotypes with APOA4: view

Human Phenotype Ontology for APOA4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for APOA4 Gene

MGI Knock Outs for APOA4:

Animal Model Products

  • Taconic Biosciences Mouse Models for APOA4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for APOA4 Gene

Localization for APOA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA4 Gene COMPARTMENTS Subcellular localization image for APOA4 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
endosome 4
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005615 extracellular space IEA,IDA 1935934
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with APOA4: view

Pathways & Interactions for APOA4 Gene

genes like me logo Genes that share pathways with APOA4: view

Pathways by source for APOA4 Gene

1 Cell Signaling Technology pathway for APOA4 Gene
1 BioSystems pathway for APOA4 Gene

Gene Ontology (GO) - Biological Process for APOA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0002227 innate immune response in mucosa IEA,IDA 15254593
GO:0006695 cholesterol biosynthetic process IBA --
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA,IDA 1935934
genes like me logo Genes that share ontologies with APOA4: view

No data available for SIGNOR curated interactions for APOA4 Gene

Drugs & Compounds for APOA4 Gene

(11) Drugs for APOA4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(18) Additional Compounds for APOA4 Gene - From: HMDB and Novoseek