External Ids for APOA4 Gene
Previous GeneCards Identifiers for APOA4 Gene
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOA4 Gene
APOA4 (Apolipoprotein A-IV) is a Protein Coding gene. Diseases associated with APOA4 include carotenemia and chronic inflammatory demyelinating polyneuropathy. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include protein homodimerization activity and copper ion binding. An important paralog of this gene is APOA1.
UniProtKB/Swiss-Prot for APOA4 Gene
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons