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Aliases for APOA2 Gene

Aliases for APOA2 Gene

  • Apolipoprotein A2 2 3 4
  • Apolipoprotein A-II 2 5
  • Apo-AII 3 4
  • ApoA-II 3 4
  • ApoAII 3

External Ids for APOA2 Gene

Previous GeneCards Identifiers for APOA2 Gene

  • GC01M158903
  • GC01M156924
  • GC01M157969
  • GC01M158408
  • GC01M158005
  • GC01M159458
  • GC01M132549

Summaries for APOA2 Gene

Entrez Gene Summary for APOA2 Gene

  • This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOA2 Gene

APOA2 (Apolipoprotein A2) is a Protein Coding gene. Diseases associated with APOA2 include hypercholesterolemia, familial and aapoaii amyloidosis. Among its related pathways are Signaling by GPCR and Lipoprotein metabolism. GO annotations related to this gene include protein homodimerization activity and lipid binding.

UniProtKB/Swiss-Prot for APOA2 Gene

  • May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Gene Wiki entry for APOA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA2 Gene

Genomics for APOA2 Gene

Regulatory Elements for APOA2 Gene

Promoters for APOA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOA2 Gene

Chromosome:
1
Start:
161,222,292 bp from pter
End:
161,223,631 bp from pter
Size:
1,340 bases
Orientation:
Minus strand

Genomic View for APOA2 Gene

Genes around APOA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA2 Gene

Proteins for APOA2 Gene

  • Protein details for APOA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02652-APOA2_HUMAN
    Recommended name:
    Apolipoprotein A-II
    Protein Accession:
    P02652
    Secondary Accessions:
    • B2R524

    Protein attributes for APOA2 Gene

    Size:
    100 amino acids
    Molecular mass:
    11175 Da
    Quaternary structure:
    • Monomer. Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP and NDRG1.

    Three dimensional structures from OCA and Proteopedia for APOA2 Gene

neXtProt entry for APOA2 Gene

Proteomics data for APOA2 Gene at MOPED

Post-translational modifications for APOA2 Gene

Antibody Products

  • R&D Systems Antibodies for APOA2 (Apolipoprotein A-II/ApoA2)

No data available for DME Specific Peptides for APOA2 Gene

Domains & Families for APOA2 Gene

Gene Families for APOA2 Gene

Protein Domains for APOA2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA2 Gene

Graphical View of Domain Structure for InterPro Entry

P02652

UniProtKB/Swiss-Prot:

APOA2_HUMAN :
  • Belongs to the apolipoprotein A2 family.
Family:
  • Belongs to the apolipoprotein A2 family.
genes like me logo Genes that share domains with APOA2: view

Function for APOA2 Gene

Molecular function for APOA2 Gene

GENATLAS Biochemistry:
apolipoprotein A-II,associated with HDL (see TSG1M)
UniProtKB/Swiss-Prot Function:
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

Gene Ontology (GO) - Molecular Function for APOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11991719
GO:0008035 high-density lipoprotein particle binding IEA,IBA --
GO:0042803 protein homodimerization activity IDA 17264082
GO:0055102 lipase inhibitor activity IDA 14967812
GO:0070653 high-density lipoprotein particle receptor binding IPI 10764676
genes like me logo Genes that share ontologies with APOA2: view
genes like me logo Genes that share phenotypes with APOA2: view

Animal Models for APOA2 Gene

MGI Knock Outs for APOA2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for APOA2 Gene

Localization for APOA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA2 Gene COMPARTMENTS Subcellular localization image for APOA2 gene
Compartment Confidence
extracellular 5
cytosol 4
endoplasmic reticulum 4
endosome 4
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for APOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome TAS --
GO:0005829 cytosol TAS --
GO:0042627 chylomicron IDA 8245722
genes like me logo Genes that share ontologies with APOA2: view

Pathways & Interactions for APOA2 Gene

genes like me logo Genes that share pathways with APOA2: view

Gene Ontology (GO) - Biological Process for APOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA 12458630
GO:0006457 protein folding IDA 14967812
GO:0006641 triglyceride metabolic process TAS 11551871
GO:0006656 phosphatidylcholine biosynthetic process IDA 14967812
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with APOA2: view

No data available for SIGNOR curated interactions for APOA2 Gene

Drugs & Compounds for APOA2 Gene

(14) Drugs for APOA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for APOA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APOA2: view

Transcripts for APOA2 Gene

Unigene Clusters for APOA2 Gene

Apolipoprotein A-II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5:
SP6: - - -

Relevant External Links for APOA2 Gene

GeneLoc Exon Structure for
APOA2
ECgene alternative splicing isoforms for
APOA2

Expression for APOA2 Gene

mRNA expression in normal human tissues for APOA2 Gene

mRNA differential expression in normal tissues according to GTEx for APOA2 Gene

This gene is overexpressed in Liver (x52.5).

Protein differential expression in normal tissues from HIPED for APOA2 Gene

This gene is overexpressed in Plasma (25.6) and Serum (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOA2 Gene



SOURCE GeneReport for Unigene cluster for APOA2 Gene Hs.237658

mRNA Expression by UniProt/SwissProt for APOA2 Gene

P02652-APOA2_HUMAN
Tissue specificity: Plasma; synthesized in the liver and intestine.
genes like me logo Genes that share expression patterns with APOA2: view

Protein tissue co-expression partners for APOA2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for APOA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOA2 35
  • 79.33 (n)
  • 71 (a)
APOA2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOA2 35
  • 85.67 (n)
  • 80 (a)
APOA2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoa2 35
  • 74.15 (n)
  • 64.29 (a)
Apoa2 16
Apoa2 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APOA2 35
  • 98.67 (n)
  • 97 (a)
APOA2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apoa2 35
  • 70.75 (n)
  • 57.14 (a)
oppossum
(Monodelphis domestica)
Mammalia APOA2 36
  • 56 (a)
OneToOne
Species with no ortholog for APOA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOA2 Gene

ENSEMBL:
Gene Tree for APOA2 (if available)
TreeFam:
Gene Tree for APOA2 (if available)

Paralogs for APOA2 Gene

No data available for Paralogs for APOA2 Gene

Variants for APOA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for APOA2 Gene

P02652-APOA2_HUMAN
A homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [MIM:107670].

Sequence variations from dbSNP and Humsavar for APOA2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5082 -- 161,223,893(-) TTGCA(C/T)TCAAG upstream-variant-2KB
rs5083 -- 161,223,592(-) TAGGT(A/C)AGATA intron-variant
rs5084 -- 161,222,799(-) TTAAA(A/T)TGCAG intron-variant
rs5085 -- 161,222,721(-) GCCTT(C/G)AATTT intron-variant
rs5086 -- 161,222,719(-) CTTSA(A/T)TTTCA intron-variant

Variation tolerance for APOA2 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOA2 Gene

HapMap Linkage Disequilibrium report
APOA2
Human Gene Mutation Database (HGMD)
APOA2

No data available for Structural Variations from Database of Genomic Variants (DGV) for APOA2 Gene

Disorders for APOA2 Gene

MalaCards: The human disease database

(19) MalaCards diseases for APOA2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypercholesterolemia, familial
  • hypercholesterolemia, familial, modifier of
aapoaii amyloidosis
  • apolipoprotein a-ii amyloidosis
apolipoprotein a-ii deficiency
  • familial apolipoprotein a-ii deficiency due to apoa-ii
norum disease
  • fish-eye disease
fish-eye disease
  • lecithin acyltransferase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search APOA2 in MalaCards View complete list of genes associated with diseases

Genatlas disease for APOA2 Gene

apolipoprotein A-II deficiency

Relevant External Links for APOA2

Genetic Association Database (GAD)
APOA2
Human Genome Epidemiology (HuGE) Navigator
APOA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOA2
genes like me logo Genes that share disorders with APOA2: view

No data available for UniProtKB/Swiss-Prot for APOA2 Gene

Publications for APOA2 Gene

  1. Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample. (PMID: 12136239) Fullerton S.M. … Nickerson D.A. (Hum. Genet. 2002) 3 4 48 67
  2. Human apolipoprotein A-II determines plasma triglycerides by regulating lipoprotein lipase activity and high-density lipoprotein proteome. (PMID: 19910634) Julve J. … Blanco-Vaca F. (Arterioscler. Thromb. Vasc. Biol. 2010) 3 23
  3. Apolipoprotein modulation of streptococcal serum opacity factor activity against human plasma high-density lipoproteins. (PMID: 19618959) Rosales C. … Pownall H.J. (Biochemistry 2009) 3 23
  4. Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia. (PMID: 19778946) Koike T. … Fan J. (Arterioscler. Thromb. Vasc. Biol. 2009) 3 23
  5. APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. (PMID: 19901143) Corella D. … Ordovas J.M. (Arch. Intern. Med. 2009) 3 23

Products for APOA2 Gene

Sources for APOA2 Gene

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