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Aliases for APOA2 Gene

Aliases for APOA2 Gene

  • Apolipoprotein A-II 2 3
  • Apolipoprotein A2 3 4
  • Apo-AII 3 4
  • ApoA-II 3 4
  • ApoAII 3

External Ids for APOA2 Gene

Previous GeneCards Identifiers for APOA2 Gene

  • GC01M158903
  • GC01M156924
  • GC01M157969
  • GC01M158408
  • GC01M158005
  • GC01M159458
  • GC01M132549

Summaries for APOA2 Gene

Entrez Gene Summary for APOA2 Gene

  • This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOA2 Gene

APOA2 (Apolipoprotein A-II) is a Protein Coding gene. Diseases associated with APOA2 include apolipoprotein a-ii deficiency and familial renal amyloidosis due to apolipoprotein aii variant. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include protein homodimerization activity and phospholipid binding.

UniProtKB/Swiss-Prot for APOA2 Gene

  • May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism

Gene Wiki entry for APOA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA2 Gene

Genomics for APOA2 Gene

Regulatory Elements for APOA2 Gene

Genomic Location for APOA2 Gene

Start:
161,222,292 bp from pter
End:
161,223,631 bp from pter
Size:
1,340 bases
Orientation:
Minus strand

Genomic View for APOA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA2 Gene

Proteins for APOA2 Gene

  • Protein details for APOA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02652-APOA2_HUMAN
    Recommended name:
    Apolipoprotein A-II
    Protein Accession:
    P02652
    Secondary Accessions:
    • B2R524

    Protein attributes for APOA2 Gene

    Size:
    100 amino acids
    Molecular mass:
    11175 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP and NDRG1.

    Three dimensional structures from OCA and Proteopedia for APOA2 Gene

neXtProt entry for APOA2 Gene

Proteomics data for APOA2 Gene at MOPED

Post-translational modifications for APOA2 Gene

Other Protein References for APOA2 Gene

Antibody Products

  • R&D Systems Antibodies for APOA2 (Apolipoprotein A-II/ApoA2)

No data available for DME Specific Peptides for APOA2 Gene

Domains for APOA2 Gene

Gene Families for APOA2 Gene

HGNC:

Protein Domains for APOA2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA2 Gene

Graphical View of Domain Structure for InterPro Entry

P02652

UniProtKB/Swiss-Prot:

APOA2_HUMAN :
  • P02652
Family:
  • Belongs to the apolipoprotein A2 family.
genes like me logo Genes that share domains with APOA2: view

Function for APOA2 Gene

Molecular function for APOA2 Gene

GENATLAS Biochemistry: apolipoprotein A-II,associated with HDL (see TSG1M)
UniProtKB/Swiss-Prot Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism

Gene Ontology (GO) - Molecular Function for APOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity IDA 1606170
GO:0005515 protein binding IPI 11991719
GO:0005543 phospholipid binding IDA 218942
GO:0008035 high-density lipoprotein particle binding IEA --
GO:0008289 lipid binding IDA 14967812
genes like me logo Genes that share ontologies with APOA2: view
genes like me logo Genes that share phenotypes with APOA2: view

Animal Models for APOA2 Gene

MGI Knock Outs for APOA2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for APOA2 Gene

Localization for APOA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA2 Gene COMPARTMENTS Subcellular localization image for APOA2 gene
Compartment Confidence
extracellular 5
cytosol 4
endoplasmic reticulum 4
endosome 4
peroxisome 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for APOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space --
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with APOA2: view

Pathways for APOA2 Gene

genes like me logo Genes that share pathways with APOA2: view

Pathways by source for APOA2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for APOA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0002526 acute inflammatory response IEA --
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA 12458630
GO:0006457 protein folding IDA 14967812
GO:0006641 triglyceride metabolic process TAS 11551871
genes like me logo Genes that share ontologies with APOA2: view

Compounds for APOA2 Gene

(30) Novoseek inferred chemical compound relationships for APOA2 Gene

Compound -log(P) Hits PubMed IDs
cholesterol 77.8 118
lipid 65.9 35
mspi 53.9 6
phospholipid 51.8 6
fenofibrate 46.4 3
genes like me logo Genes that share compounds with APOA2: view

Transcripts for APOA2 Gene

mRNA/cDNA for APOA2 Gene

Unigene Clusters for APOA2 Gene

Apolipoprotein A-II:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5:
SP6: - - -

Relevant External Links for APOA2 Gene

GeneLoc Exon Structure for
APOA2
ECgene alternative splicing isoforms for
APOA2

Expression for APOA2 Gene

mRNA expression in normal human tissues for APOA2 Gene

mRNA differential expression in normal tissues according to GTEx for APOA2 Gene

This gene is overexpressed in Liver (52.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APOA2 Gene

SOURCE GeneReport for Unigene cluster for APOA2 Gene Hs.237658

mRNA Expression by UniProt/SwissProt for APOA2 Gene

P02652-APOA2_HUMAN
Tissue specificity: Plasma; synthesized in the liver and intestine
genes like me logo Genes that share expressions with APOA2: view

In Situ Assay Products

Orthologs for APOA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOA2 35
  • 98.67 (n)
  • 97 (a)
APOA2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOA2 35
  • 79.33 (n)
  • 71 (a)
APOA2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOA2 35
  • 85.67 (n)
  • 80 (a)
APOA2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoa2 35
  • 74.15 (n)
  • 64.29 (a)
Apoa2 16
Apoa2 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APOA2 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apoa2 35
  • 70.75 (n)
  • 57.14 (a)
Species with no ortholog for APOA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOA2 Gene

ENSEMBL:
Gene Tree for APOA2 (if available)
TreeFam:
Gene Tree for APOA2 (if available)

Paralogs for APOA2 Gene

No data available for Paralogs for APOA2 Gene

Variants for APOA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for APOA2 Gene

P02652-APOA2_HUMAN
A homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [MIM:107670]

Sequence variations from dbSNP and Humsavar for APOA2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5082 -- 161,223,893(-) TTGCA(C/T)TCAAG upstream-variant-2KB
rs5083 -- 161,223,592(-) TAGGT(A/C)AGATA intron-variant
rs5084 -- 161,222,799(-) TTAAA(A/T)TGCAG intron-variant
rs5085 -- 161,222,721(-) GCCTT(C/G)AATTT intron-variant
rs5086 -- 161,222,719(-) CTTSA(A/T)TTTCA intron-variant

Relevant External Links for APOA2 Gene

HapMap Linkage Disequilibrium report
APOA2
Human Gene Mutation Database (HGMD)
APOA2

No data available for Structural Variations from Database of Genomic Variants (DGV) for APOA2 Gene

Disorders for APOA2 Gene

(1) OMIM Diseases for APOA2 Gene (107670)

(32) Novoseek inferred disease relationships for APOA2 Gene

Disease -log(P) Hits PubMed IDs
fish-eye disease 77.8 2
tangier disease 77.1 2
hypoalphalipoproteinemia 75.6 2
lecithin cholesterol acyltransferase deficiency 74.8 1
lcat deficiency 72.4 4

Genatlas disease for APOA2 Gene

apolipoprotein A-II deficiency

Relevant External Links for APOA2

Genetic Association Database (GAD)
APOA2
Human Genome Epidemiology (HuGE) Navigator
APOA2
genes like me logo Genes that share disorders with APOA2: view

No data available for UniProtKB/Swiss-Prot for APOA2 Gene

Publications for APOA2 Gene

  1. A splice-junction mutation responsible for familial apolipoprotein A- II deficiency. (PMID: 2107739) Deeb S.S. … Albers J.J. (Am. J. Hum. Genet. 1990) 3 4 23
  2. Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein. (PMID: 12576517) Pankhurst G. … Stocker R. (J. Lipid Res. 2003) 3 4 23
  3. APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. (PMID: 19901143) Corella D. … Ordovas J.M. (Arch. Intern. Med. 2009) 3 23 48
  4. Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample. (PMID: 12136239) Fullerton S.M. … Nickerson D.A. (Hum. Genet. 2002) 3 4 48
  5. Structures of apolipoprotein A-II and a lipid-surrogate complex provide insights into apolipoprotein-lipid interactions. (PMID: 12269810) Kumar M.S. … Murthy H.M. (Biochemistry 2002) 3 4

Products for APOA2 Gene

Sources for APOA2 Gene

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