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Aliases & Descriptions for APOA2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Apo-AII 3 | | ApoA-II 3 | | OTTHUMP00000032244 2 |
| | | Descriptions |
|---|
| apolipoprotein A-II 2 |
|
| | Search outside databases for aliases for APOA2 genePrevious GC identifers: GC01M158903 GC01M156924 GC01M157969 GC01M158408 GC01M158005 |
Summaries for APOA2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for APOA2: This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq] UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolismGene Wiki entry for APOA2 |
Genomic Location for APOA2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the APOA2 gene 
Entrez Gene cytogenetic band: 1q21-q23 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q21-q23APOA2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M159458:
(about GC identifiers)
Start:
|
159,458,707 bp from pter |
End:
|
159,460,042 bp from pter |
Size:
|
1,336 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for APOA2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652 (See
protein sequence)Recommended Name: Apolipoprotein A-II precursor Size: 100 amino acids; 11175 Da
Subunit: Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP
Subcellular location: Secreted
Mass spectrometry: Mass=8701.2; Method=MALDI; Range=24-100; Source=PubMed:12562854;
Mass spectrometry: Mass=8823.4; Method=MALDI; Range=24-100; Note=Cysteinylated ApoA-II; Source=PubMed:12562854;
Mass spectrometry: Mass=17421.3; Method=MALDI; Range=24-100; Note=Homodimer; Source=PubMed:12562854;
Mass spectrometry: Mass=17293.4; Method=MALDI; Range=24-100; Note=Heterodimer with apolipoprotein A-II(1-76); Source=PubMed:12562854;
Mass spectrometry: Mass=8578.3; Method=MALDI; Range=24-99; Source=PubMed:12562854;
Mass spectrometry: Mass=17166.2; Method=MALDI; Range=24-99; Note=Homodimer; Source=PubMed:12562854;
PDB structure from and Proteopedia :1L6L (3D)
 2OU1 (3D)
 
Secondary accessions: B2R524REFSEQ proteins: NP_001634.1
ENSEMBL proteins: ENSP00000356969
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for APOA2: Assays for APOA2: | Protein
Domains/ Families for APOA2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P02652
ProtoNet protein and cluster: P02652 1 Blocks protein family: IPB006801 Apolipoprotein A-II (ApoA-II)
UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652Similarity: Belongs to the apolipoprotein A2 family | Gene Function for APOA2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001643
Applied Biosystems Silencer® siRNAs for APOA2
Sigma-Aldrich siRNA and siRNA Panels for APOA2  Sigma-Aldrich shRNA for APOA2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001643                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001643                                  untagged cDNA clone in CMV expression vector: NM_001643 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001643
UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolismGenatlas biochemistry entry for APOA2:apolipoprotein A-II,associated with HDL (see TSG1M)3 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Apoa2):
5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11
): About this table | Pathways & Interactions for APOA2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for APOA2 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for APOA2 
5/52 Interacting proteins for APOA2 (ENSP000003569693) via UniProtKB, MINT, and/or STRING (see all 52
)About this table
5/23 Gene Ontology (GO) biological process terms (links to tree view) (see all 23
): About this table
|
Drugs & Compounds for APOA2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for APOA2 10/19 Novoseek chemical compound relationships for APOA2 gene (see all 19
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cholesterol |
78.19 |
186 |
2105749 (4), 11773507 (4), 9651324 (3), 1591822 (3) (see all 86) |
| lipid |
66.21 |
40 |
9022694 (4), 9651324 (2), 9895287 (2), 9578492 (2) (see all 29) |
| mspi |
54.83 |
6 |
1352975 (3), 1281133 (2), 9001797 (1) |
| phospholipid |
51.88 |
6 |
9254056 (2), 10335875 (1), 12671027 (1), 11162594 (1) (see all 5) |
| cholesterol ester |
36.82 |
1 |
17872455 (1) |
| triacylglycerol |
28.83 |
4 |
14967812 (2), 15158304 (1) |
| p-opc |
28.67 |
1 |
10588955 (1) |
| sulfoxide |
27.85 |
2 |
15680225 (1), 12576517 (1) |
| fibrinogen |
24.97 |
4 |
1505660 (1), 7869910 (1), 11730086 (1), 1385959 (1) |
| dimyristoylphosphatidylcholine |
22.28 |
2 |
7869853 (1), 15681655 (1) |
About this table
|
Transcripts for APOA2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001643
Sigma-Aldrich siRNA and siRNA Panels for APOA2  Sigma-Aldrich shRNA for APOA2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001643 REFSEQ mRNAs for APOA2 gene: NM_001643.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001643               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001643                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001643                                  untagged cDNA clone in CMV expression vector: NM_001643  Additional cDNA sequence: AB106565.1 AK312034.1 BC005282.1 BT006786.1 CR592632.1 CR595207.1 CR605230.1 CR619946.1 M29882.1 X00955.1 17 DOTS entries: DT.92454627 DT.92454636 DT.121399929 DT.99986662 DT.100820522 DT.100820519 DT.87017590 DT.95260166 DT.95260217 DT.100820518 DT.121399912 DT.121399918 DT.121399913 DT.121399938 DT.121399945 DT.92454617 DT.95260191 24/591 AceView cDNA sequences (see all 591
):N72943 H67695 AI114547 BX097461 AV685162 H79808 AV682280 M29882 AV682464 T97810 CR595207 T72409 N52475 AV660082 H56064 NM_001643 AV645683 AI200608 H94639 CR592632 AV681734 AV682049 H58549 N75301
highest scoring ESTs for APOA2:AA029535 AA344879 AA345457 AA345604 AA345620 AA484505 AA484832 AA484927 AA492025 AA501731 Unigene Cluster for APOA2: Apolipoprotein A-II Hs.237658 [show with all ESTs]Unigene Representative Sequence: CR619946
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for APOA2 (see all 6
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | |
| SP1: | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for APOA2
1 Ensembl transcript including schematic representation: ENST00000367990
|
Expression for APOA2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| APOA2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for APOA2
1 / 2 / 3 4 probe-sets matching APOA2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGTGGAGAGC
SOURCE GeneReport for Unigene cluster: Hs.237658 UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652Tissue specificity: Plasma; synthesized in the liver and intestine |
Orthologs for APOA2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for APOA2 gene from 5 species
About this table Species with no ortholog for APOA2
ENSEMBL Gene Tree for APOA2 | Paralogs for APOA2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for APOA2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for APOA2 (up to first 250kb)
|
Disorders & Mutations for APOA2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 107670 10/31 Novoseek disease relationships for APOA2 gene (see all 31
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fish-eye disease |
78.46 |
3 |
8282802 (2) |
| tangier disease |
77.71 |
2 |
8347683 (1), 8348751 (1) |
| hypoalphalipoproteinemia |
75.97 |
2 |
7712672 (1), 12364558 (1) |
| lecithin cholesterol acyltransferase deficiency |
75.33 |
2 |
8282802 (1) |
| lcat deficiency |
73.34 |
6 |
8282802 (2), 10206431 (1), 8018670 (1) |
| hyperalphalipoproteinemia |
67.87 |
1 |
8462178 (1) |
| cetp deficiency |
64.86 |
1 |
14657195 (1) |
| atherosclerosis |
54.17 |
9 |
11714842 (2), 11742873 (1), 17373959 (1), 15466364 (1) (see all 6) |
| hypertriglyceridemia |
52.06 |
6 |
15466364 (1), 7989603 (1), 17709437 (1), 9001797 (1) (see all 5) |
| hypertriglyceridemias familial |
50.47 |
2 |
1907081 (2) |
About this table
Genatlas disease: APOA2 apolipoprotein A-II deficiency Human Gene Mutation Database: APOA2 Genetic Association Database: APOA2 Human Genome Epidemiology Navigator: APOA2 (17 documents)
|
Medical News for APOA2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for APOA2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/331 PubMed articles for APOA2 gene (see all 331
):- Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample. (PubMed id 12136239)3, 4, 6 Fullerton S.M.... Nickerson D.A. (2002)
- Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins. (PubMed id 12562854)1, 3, 4 Niederkofler E.E.... Nelson R.W. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Apolipoprotein A-II polymorphism and visceral adiposity in African-American and white women. (PubMed id 15833935)3, 6 Lara-Castro C....Fernandez J.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Physical activity modulates effects of some genetic polymorphisms affecting cardiovascular risk in men aged over 40 years. (PubMed id 14650352)3, 6 Pisciotta L....Bertolini S. (2003)
- Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. (PubMed id 11991719)3, 4 Ritter M....Schmitz G. (2002)
- Structures of apolipoprotein A-II and a lipid-surrogate complex provide insights into apolipoprotein-lipid interactions. (PubMed id 12269810)3, 4 Kumar M.S.... Murthy H.M. (2002)
- Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. (PubMed id 12116231)3, 6 Han Z....Breslow J.L. (2002)
- Significant impact of the highly informative (CA)n repeat polymorphism of the APOA-II gene on the plasma APOA-II concentrations and HDL subfractions: The ECTIM study. (PubMed id 12116266)3, 6 Brousseau T....Helbecque N. (2002)
|
Search for APOA2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing APOA2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing APOA2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing APOA2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA2 |
|
| | | About This Section
| --
| Services for APOA2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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