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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOA2 Gene

protein-coding   GIFtS: 61
GCID: GC01M161192

Apolipoprotein A-II

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apolipoprotein A-II1 2
Apolipoprotein A22 3
Apo-AII2 3
ApoA-II2 3
apoAII2

External Ids:    HGNC: 6011   Entrez Gene: 3362   Ensembl: ENSG000001588747   OMIM: 1076705   UniProtKB: P026523   

Export aliases for APOA2 gene to outside databases

Previous GC identifers: GC01M158903 GC01M156924 GC01M157969 GC01M158408 GC01M158005 GC01M159458 GC01M132549


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOA2 Gene:
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density
lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein
D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. (provided by
RefSeq, Jul 2008)

GeneCards Summary for APOA2 Gene: 
APOA2 (apolipoprotein A-II) is a protein-coding gene. Diseases associated with APOA2 include hypercholesterolemia, familial, modification of, and familial renal amyloidosis due to apolipoprotein aii variant, and among its related super-pathways are Lipoprotein metabolism and Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include phospholipid binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652
Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the
HDL metabolism

Gene Wiki entry for APOA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOA2 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   LCR-F1   CREB   PPAR-gamma1   E2F   E2F-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): APOA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for APOA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

APOA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOA2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M161192:  view genomic region     (about GC identifiers)

Start:
161,192,082 bp from pter      End:
161,193,421 bp from pter
Size:
1,340 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652 (See protein sequence)
Recommended Name: Apolipoprotein A-II precursor  
Size: 100 amino acids; 11175 Da
Subunit: Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core
protein. Interacts with APOA1BP and NDRG1
Subcellular location: Secreted
Mass spectrometry: Mass=17252; Method=Electrospray; Range=24-100; Note=Homodimer, without methionine sulfoxide;
Source=PubMed:12576517;
Mass spectrometry: Mass=17269; Method=Electrospray; Range=24-100; Note=Homodimer, with 1 methionine sulfoxide,
oxidation at Met-49; Source=PubMed:12576517;
Mass spectrometry: Mass=8701.2; Method=MALDI; Range=24-100; Source=PubMed:12562854;
Mass spectrometry: Mass=8823.4; Method=MALDI; Range=24-100; Note=Cysteinylated ApoA-II; Source=PubMed:12562854;
Mass spectrometry: Mass=17421.3; Method=MALDI; Range=24-100; Note=Homodimer; Source=PubMed:12562854;
Mass spectrometry: Mass=17293.4; Method=MALDI; Range=24-100; Note=Heterodimer with truncated apolipoprotein A-II;
Source=PubMed:12562854;
Mass spectrometry: Mass=8578.3; Method=MALDI; Range=24-99; Source=PubMed:12562854;
Mass spectrometry: Mass=17166.2; Method=MALDI; Range=24-99; Note=Homodimer; Source=PubMed:12562854;
2 PDB 3D structures from and Proteopedia for APOA2:
1L6L (3D)        2OU1 (3D)    
Secondary accessions: B2R524

Explore the universe of human proteins at neXtProt for APOA2: NX_P02652

Explore proteomics data for APOA2 at MOPED 

Post-translational modifications:

  • UniProtKB: Met-49 is oxidized to methionine sulfoxide
  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • UniProtKB: Apolipoprotein A-II is O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02652

  • APOA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APOA2 Protein Expression
    REFSEQ proteins: NP_001634.1  
    ENSEMBL proteins: 
     ENSP00000356969  
    Reactome Protein details: P02652
    Human Recombinant Protein Products for APOA2: 
    EMD Millipore Purified and/or Recombinant APOA2 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for APOA2 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ----
    GO:0005769early endosome TAS--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005829cytosol TAS--

    APOA2 for ontologies           About GeneDecksing



    APOA2 Antibody Products: 
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    ThermoFisher Antibodies for APOA2
    LSBio Antibodies in human, mouse, rat for APOA2 

    Assay Products for APOA2: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for APOA2 
    Cloud-Clone Corp. CLIAs for APOA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    APOLIPO: Apolipoproteins

    1 InterPro protein domain:
     IPR006801 ApoA-II

    Graphical View of Domain Structure for InterPro Entry P02652

    ProtoNet protein and cluster: P02652

    1 Blocks protein domain: IPB006801 Apolipoprotein A-II (ApoA-II)

    UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652
    Similarity: Belongs to the apolipoprotein A2 family


    APOA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOA2_HUMAN, P02652
    Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the
    HDL metabolism

         Genatlas biochemistry entry for APOA2:
    apolipoprotein A-II,associated with HDL (see TSG1M)

         Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005319lipid transporter activity IDA1606170
    GO:0005515protein binding IPI11991719
    GO:0005543phospholipid binding IDA218942
    GO:0008035high-density lipoprotein particle binding IEA--
    GO:0008289lipid binding IDA14967812
         
    APOA2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for APOA2:
     Decreased viability of wild-ty  Increased G2M DNA content, inc 

         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Apoa2):
     growth/size  homeostasis/metabolism  other 

    APOA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Apoa2tm1Bres for APOA2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for APOA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APOA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOA2 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APOA2 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Lipoprotein metabolism
    Lipoprotein metabolism0.57
    Lipid digestion, mobilization, and transport0.56
    Chylomicron-mediated lipid transport0.57
    2Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    PPARA Activates Gene Expression0.74
    3Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    Retinoid metabolism and transport0.48
    4Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    5Statin Pathway, Pharmacodynamics
    Statin Pathway0.73

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for APOA2
        Selected targets of HNF1


    1 GeneGo (Thomson Reuters) Pathway for APOA2
        Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)

    2 BioSystems Pathways for APOA2
        Statin Pathway
    Complement and Coagulation Cascades

    5/13        Reactome Pathways for APOA2 (see all 13)
        Diseases associated with visual transduction
    Metabolism
    Chylomicron-mediated lipid transport
    Visual phototransduction
    Disease


    1         Kegg Pathway  (Kegg details for APOA2):
        PPAR signaling pathway


    APOA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APOA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for APOA2 (P026523 ENSP000003569694) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C4AP0C0L43, ENSP000003966884I2D: score=1 STRING: ENSP00000396688
    ENSG00000206340P0C0L43I2D: score=1 
    ENSG00000227746P0C0L43I2D: score=1 
    APOC1P026543, ENSP000002524914I2D: score=1 STRING: ENSP00000252491
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    About this table

    Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0002526acute inflammatory response IEA--
    GO:0002740negative regulation of cytokine secretion involved in immune response IDA12458630
    GO:0006457protein folding IDA14967812
    GO:0006641triglyceride metabolic process TAS11551871

    APOA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOA2

    10/30 Novoseek inferred chemical compound relationships for APOA2 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 77.8 191 2105749 (4), 11773507 (4), 9651324 (3), 1591822 (3) (see all 89)
    lipid 65.9 40 9022694 (4), 9651324 (2), 9895287 (2), 9578492 (2) (see all 29)
    mspi 53.9 6 1352975 (3), 1281133 (2), 9001797 (1)
    phospholipid 51.8 6 9254056 (2), 10335875 (1), 12671027 (1), 11162594 (1) (see all 5)
    fenofibrate 46.4 3 19325138 (2), 7635967 (1)
    cholesterol ester 35.6 1 17872455 (1)
    intralipid 34.7 1 8944748 (1)
    bezafibrate 27.3 3 8871265 (2)
    triacylglycerol 27.3 4 14967812 (2), 15158304 (1)
    phosphatidylcholine 27.2 5 8934442 (1), 9610765 (1), 10569952 (1), 10588955 (1)

    Search CenterWatch for drugs/clinical trials and news about APOA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APOA2 gene: 
    NM_001643.1  

    Unigene Cluster for APOA2:

    Apolipoprotein A-II
    Hs.237658  [show with all ESTs]
    Unigene Representative Sequence: BU959980
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481413 ENST00000367990(uc001fzc.1) ENST00000468465(uc001fzb.1)
    ENST00000463812 ENST00000481511 ENST00000470459 ENST00000464492 ENST00000491350
    ENST00000469730 ENST00000463273
    miRNA
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    Additional mRNA sequence: 

    AB106565.1 AK312034.1 BC005282.1 BT006786.1 M29882.1 X00955.1 

    17 DOTS entries:

    DT.92454627  DT.92454636  DT.121399929  DT.99986662  DT.100820522  DT.100820519  DT.95260166  DT.95260217 
    DT.100820518  DT.121399912  DT.121399918  DT.87017590  DT.121399913  DT.121399938  DT.121399945  DT.95260191 
    DT.92454617 

    24/591 AceView cDNA sequences (see all 591):

    N53792 CB144717 AB106565 BX097461 R92427 BQ012113 AA344879 AV685162 
    N75301 AV682854 CR595207 R29199 N72943 AV682464 T69597 AI114547 
    AV682626 H94639 AA342503 CR605230 AV645933 AI200608 BQ653709 AV681768 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for APOA2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:              -                 -                                 
    SP2:              -                 -     -                           
    SP3:                                -                                 
    SP4:              -     -     -     -                                 
    SP5:                                                                  


    ECgene alternative splicing isoforms for APOA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOA2 expression in normal human tissues (normalized intensities)      APOA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGAGAGC
    APOA2 Expression
    About this image


    APOA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Liver Lobule
             Hepatocyte-like cells ( Functional hepatocyte generation from human embryonic stem...
             Human Hepatocyte (HH)   
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Gut Tube (Gastrointestinal Tract)
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...

    See APOA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOA2

    SOURCE GeneReport for Unigene cluster: Hs.237658

    UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652
    Tissue specificity: Plasma; synthesized in the liver and intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including APOA2: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for APOA2 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apoa21 , 5 apolipoprotein A-II1, 5 74.15(n)1
    64.29(a)1
      1 (79.22 cM)5
    118071  NM_013474.21  NP_038502.21 
     1712250545 


    ENSEMBL Gene Tree for APOA2 (if available)
    TreeFam Gene Tree for APOA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652
    Polymorphism: A homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein
    A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary
    artery disease [MIM:107670]


    10/118 SNPs in APOA2 are shown (see all 118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs723743751,2
    C--161192846(+) CTGCC-/CACAC 
     ACACACA
    CACAC
    1 -- int10--------
    rs1415991251,2
    C--161192846(+) CTGCC-/CACACA
            
    CACAC
    1 -- int10--------
    rs172445021,2
    C,F--161192873(-) AAAGA-/GT/GTGT/GTGTGT/GTGTGTGT/GTGTGTGTGT/GTG
    TGTGTGTGT
    /GTGTGTGTGTGTGT/GTGTGTGTGTGTGTGT
    GTGTG
    2 -- int1 cds13NS NA 98
    rs1870387321,2
    --167687866(+) TGGGAC/TTACAG 1 -- ds50010--------
    rs1493497721,2
    C--167687875(+) AGGCAC/TGTGCC 1 -- ds50010--------
    rs127210361,2
    C,F--167687949(-) GAGTTC/ACAGAC 1 -- ds50016Minor allele frequency- A:0.11NS NA WA 246
    rs121432411,2
    C,F--167687999(+) GCAGGG/AATTAC 1 -- ds50017Minor allele frequency- A:0.10NS NA 248
    rs1162431941,2
    F--167688264(+) CCTTCT/CAGAAG 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs768167171,2
    C--167688347(+) CTCAGA/TGCTGG 1 -- ds50010--------
    rs802688981,2
    C--167688348(-) TCCAGA/C/GTCTGA 1 -- ds50011CSA 1

    HapMap Linkage Disequilibrium report for APOA2 (161192082 - 161193421 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for APOA2: --

    Human Gene Mutation Database (HGMD): APOA2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing APOA2
    DNA2.0 Custom Variant and Variant Library Synthesis for APOA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107670   
    OMIM disorders: 143890  
    20/55 diseases for APOA2 (see all 55):    About MalaCards
    hypercholesterolemia, familial, modification of    familial renal amyloidosis due to apolipoprotein aii variant    familial hyperlipidemia    fish-eye disease
    familial hypertriglyceridemia    arcus senilis    norum disease    tangier disease
    hyperalphalipoproteinemia    hypoalphalipoproteinemias    hereditary amyloidosis    cetp deficiency
    hypercholesterolemia    carotid artery disease    eye disease    familial combined hyperlipidemia
    cerebral infarction    hyperthyroidism    amyloidosis    hypertriglyceridemia

    7 diseases from the University of Copenhagen DISEASES database for APOA2:
    Tangier disease     Atherosclerosis     Coronary heart disease     Amyloidosis
    Familial hyperlipidemia     Norum disease     Diabetes mellitus

    APOA2 for disorders           About GeneDecksing

    10/32 Novoseek inferred disease relationships for APOA2 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fish-eye disease 77.8 3 8282802 (2)
    tangier disease 77.1 2 8347683 (1), 8348751 (1)
    hypoalphalipoproteinemia 75.6 2 7712672 (1), 12364558 (1)
    lecithin cholesterol acyltransferase deficiency 74.8 2 8282802 (1)
    lcat deficiency 72.4 6 8282802 (2), 10206431 (1), 8018670 (1)
    hyperalphalipoproteinemia 67.2 1 8462178 (1)
    hypertriglyceridemias familial 66.1 2 1907081 (2)
    cetp deficiency 64.1 1 14657195 (1)
    hyperlipidemia familial combined 56.1 3 15166779 (2), 15388641 (1)
    hypertriglyceridemia 54.6 6 15466364 (1), 7989603 (1), 17709437 (1), 9001797 (1) (see all 5)

    Genatlas disease: APOA2
    apolipoprotein A-II deficiency

    Genetic Association Database (GAD): APOA2
    Human Genome Epidemiology (HuGE) Navigator: APOA2 (43 documents)

    Export disorders for APOA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOA2 gene, integrated from 9 sources (see all 374):
    (articles sorted by number of sources associating them with APOA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample. (PubMed id 12136239)1, 2, 4 Fullerton S.M.... Nickerson D.A. (2002)
    2. Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein. (PubMed id 12576517)1, 2, 9 Pankhurst G....Stocker R. (2003)
    3. A splice-junction mutation responsible for familial apolipoprotein A-II deficiency. (PubMed id 2107739)1, 2, 9 Deeb S.S....Albers J.J. (1990)
    4. APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. (PubMed id 19901143)1, 4, 9 Corella D....Ordovas J.M. (2009)
    5. Candidate genetic analysis of plasma high-density lip oprotein-cholesterol and severity of coronary atherosclerosis. (PubMed id 19878569)1, 4, 9 Chen S.N....Marian A.J. (2009)
    6. Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins. (PubMed id 12562854)1, 2, 9 Niederkofler E.E.... Nelson R.W. (2003)
    7. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    8. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    9. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    10. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 336 HGNC: 601 AceView: APOA2 Ensembl:ENSG00000158874 euGenes: HUgn336
    ECgene: APOA2 Kegg: 336 H-InvDB: APOA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOA2 Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APOA2 gene:
    Search GeneIP for patents involving APOA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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