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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APOA2 Gene

protein-coding GIFtS: 62
GCID: GC01M161192

apolipoprotein A-II

Explore 57 diseases affiliated with
APOA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Apolipoprotein A-II¹ ²
Apolipoprotein A2² ³
Apo-AII² ³
ApoA-II² ³
ApoAII¹

External Ids:	HGNC: 601¹	Entrez Gene: 336²	Ensembl: ENSG00000158874⁷	OMIM: 107670⁵	UniProtKB: P02652³

Export aliases for APOA2 gene to outside databases

Previous GC identifers: GC01M158903 GC01M156924 GC01M157969 GC01M158408 GC01M158005 GC01M159458 GC01M132549

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOA2:

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein

particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in

this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652

Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL

metabolism

Gene Wiki entry for APOA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APOA2 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 LCR-F1 CREB PPAR-gamma1 E2F E2F-1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): APOA2 promoter sequence

Search SABiosciences Chromatin IP Primers for APOA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.3

APOA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOA2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M161192: view genomic region (about GC identifiers)

Start:	161,192,082 bp from pter	End:	161,193,421 bp from pter
Size:	1,340 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652 (See protein sequence)

Recommended Name: Apolipoprotein A-II precursor

Size: 100 amino acids; 11175 Da

Subunit: Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core

protein. Interacts with APOA1BP and NDRG1

Subcellular location: Secreted

Mass spectrometry: Mass=17252; Method=Electrospray; Range=24-100; Note=Homodimer, without methionine sulfoxide;

Source=PubMed:12576517;

Mass spectrometry: Mass=17269; Method=Electrospray; Range=24-100; Note=Homodimer, with 1 methionine sulfoxide,

oxidation at Met-49; Source=PubMed:12576517;

Mass spectrometry: Mass=8701.2; Method=MALDI; Range=24-100; Source=PubMed:12562854;

Mass spectrometry: Mass=8823.4; Method=MALDI; Range=24-100; Note=Cysteinylated ApoA-II; Source=PubMed:12562854;

Mass spectrometry: Mass=17421.3; Method=MALDI; Range=24-100; Note=Homodimer; Source=PubMed:12562854;

Mass spectrometry: Mass=17293.4; Method=MALDI; Range=24-100; Note=Heterodimer with truncated apolipoprotein A-II;

Source=PubMed:12562854;

Mass spectrometry: Mass=8578.3; Method=MALDI; Range=24-99; Source=PubMed:12562854;

Mass spectrometry: Mass=17166.2; Method=MALDI; Range=24-99; Note=Homodimer; Source=PubMed:12562854;

2 PDB 3D structures from and Proteopedia for APOA2:

1L6L (3D)

2OU1 (3D)

Secondary accessions: B2R524

Explore the universe of human proteins at neXtProt for APOA2: NX_P02652

Post-translational modifications:

Met-49 is oxidized to methionine sulfoxide¹

Phosphorylation sites are present in the extracellular medium¹

Apolipoprotein A-II is O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02652

APOA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001634.1

ENSEMBL proteins:

ENSP00000356969

Reactome Protein details: P02652
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant APOA2 Protein
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	Novus Biologicals APOA2 Proteins Novus Biologicals APOA2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for APOA2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	--	--
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0034361	very-low-density lipoprotein particle	IDA	8245722
GO:0034364	high-density lipoprotein particle	IDA	210174

APOA2 for ontologies About GeneDecksing

APOA2 Antibody Products:

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	Novus Biologicals APOA2 Antibodies
	Abcam antibodies for APOA2
	Uscn Antibodies for APOA2
	ThermoFisher Antibodies for APOA2

Assay Products for APOA2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for APOA2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for APOA2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

APOA2 for domains About GeneDecksing

1 InterPro domain/family:

IPR006801 ApoA-II

Graphical View of Domain Structure for InterPro Entry P02652

ProtoNet protein and cluster: P02652

1 Blocks protein family: IPB006801 Apolipoprotein A-II (ApoA-II)

UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652

Similarity: Belongs to the apolipoprotein A2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652

Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL

metabolism

Genatlas biochemistry entry for APOA2:

apolipoprotein A-II,associated with HDL (see TSG1M)

miRNA Products:		OriGene 3'-UTR Clone: APOA2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOA2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate APOA2
		SwitchGear 3'UTR luciferase reporter plasmid: APOA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOA2 (see all 7) OriGene shRNA RFP: APOA2 OriGene siRNA: APOA2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOA2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for APOA2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOA2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOA2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APOA2 (NM_001643)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for APOA2
		Search LifeMap BioReagents cell lines for APOA2

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for APOA2

Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005319	lipid transporter activity	IDA	1606170
GO:0005515	protein binding	IPI	17786215
GO:0005543	phospholipid binding	IDA	218942
GO:0008035	high-density lipoprotein particle binding	IEA	--
GO:0008289	lipid binding	IDA	14967812

APOA2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for APOA2:

Decreased viability of wild-ty

Increased G2M DNA content, inc

Animal Models:
Mouse knock-out Apoa2^tm1Bres for APOA2
3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Apoa2):

growth/size

homeostasis/metabolism

other

APOA2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lipoprotein metabolism

	Lipoprotein metabolism	1.00			Lipid digestion, mobilization, and transport	0.56
	Chylomicron-mediated lipid transport	0.57

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	1.00			Fatty acid, triacylglycerol, and ketone body metabolism	0.52
	PPARA Activates Gene Expression	0.74

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)

Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for APOA2

Selected targets of HNF1

1 GeneGo (Thomson Reuters) Pathway for APOA2

Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)

1 BioSystems Pathway for APOA2

Statin Pathway

5/14 Reactome Pathways for APOA2 (see all 14)

	Diseases associated with visual transduction
	Expression of APOA2
	Metabolism
	Chylomicron-mediated lipid transport
	Visual phototransduction

1 Kegg Pathway (Kegg details for APOA2):

PPAR signaling pathway

APOA2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for APOA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/34 Interacting proteins for APOA2 (P02652³ ENSP00000356969⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOC1	P02654³, ENSP00000252491⁴	I2D: score=1 STRING: ENSP00000252491
CFTR	P13569³, ENSP00000003084⁴	I2D: score=1 STRING: ENSP00000003084
APOD	P05090³, ENSP00000345179⁴	I2D: score=2 STRING: ENSP00000345179
APOF	Q13790³, ENSP00000381250⁴	I2D: score=2 STRING: ENSP00000381250
C4A	P0C0L4³, ENSP00000396688⁴	I2D: score=1 STRING: ENSP00000396688

About this table

Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002526	acute inflammatory response	IEA	--
GO:0002740	negative regulation of cytokine secretion involved in immune response	IDA	12458630
GO:0006457	protein folding	IDA	14967812
GO:0006629	lipid metabolic process	TAS	--
GO:0006641	triglyceride metabolic process	TAS	11551871

APOA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

APOA2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for APOA2
10/30 Novoseek chemical compound relationships for APOA2 gene (see all 30) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cholesterol	77.8	191	2105749 (4), 11773507 (4), 9651324 (3), 1591822 (3) (see all 89)
lipid	65.9	40	9022694 (4), 9651324 (2), 9895287 (2), 9578492 (2) (see all 29)
mspi	53.9	6	1352975 (3), 1281133 (2), 9001797 (1)
phospholipid	51.8	6	9254056 (2), 10335875 (1), 12671027 (1), 11162594 (1) (see all 5)
fenofibrate	46.4	3	19325138 (2), 7635967 (1)
cholesterol ester	35.6	1	17872455 (1)
intralipid	34.7	1	8944748 (1)
bezafibrate	27.3	3	8871265 (2)
triacylglycerol	27.3	4	14967812 (2), 15158304 (1)
phosphatidylcholine	27.2	5	8934442 (1), 9610765 (1), 10569952 (1), 10588955 (1)

Search CenterWatch for drugs/clinical trials and news about APOA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APOA2 gene:

NM_001643.1

Unigene Cluster for APOA2:

Apolipoprotein A-II

Hs.237658 [show with all ESTs]

Unigene Representative Sequence: BU959980

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000481413 ENST00000367990(uc001fzc.1) ENST00000468465(uc001fzb.1)

ENST00000463812 ENST00000481511 ENST00000470459 ENST00000464492 ENST00000491350

ENST00000469730 ENST00000463273

miRNA Products:		OriGene 3'-UTR Clone: APOA2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOA2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate APOA2
		SwitchGear 3'UTR luciferase reporter plasmid: APOA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOA2 (see all 7) OriGene shRNA RFP: APOA2 OriGene siRNA: APOA2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOA2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOA2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOA2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APOA2 (NM_001643)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOA2

Additional cDNA sequence:

AB106565.1 AK312034.1 BC005282.1 BT006786.1 M29882.1 X00955.1

17 DOTS entries:

DT.92454627 DT.92454636 DT.121399929 DT.99986662 DT.100820522 DT.100820519 DT.95260166 DT.95260217

DT.100820518 DT.121399912 DT.121399918 DT.87017590 DT.121399913 DT.121399938 DT.121399945 DT.95260191

DT.92454617

24/591 AceView cDNA sequences (see all 591):

AA342503 AV647784 AV685694 BX097461 CR619946 AV681986 R29040 H67695

R29738 AV682049 AV682626 AV653140 N52475 T73429 AV682280 AV645719

BX441362 AV682114 BQ649746 BQ647037 H79808 AV682524 BG568960 CR592632

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for APOA2 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:					-						-
SP2:					-						-		-
SP3:											-
SP4:					-		-		-		-
SP5:

ECgene alternative splicing isoforms for APOA2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APOA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGGAGAGC

About this image

APOA2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

Hepatocyte-like cells (Functional hepatocyt...)

Definitive endoderm-like cells (Generation and expan...)

Endoderm progenitor-like cells (Generation and expan...)

Definitive endoderm-like cells (Generation of mesend...)

Mesendoderm-like cells (Generation of mesend...)

Posterior foregut-like cells (A scalable, suspensi...)

DKK1-induced cells (Derivation of cardio...)

See APOA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APOA2

SOURCE GeneReport for Unigene cluster: Hs.237658

UniProtKB/Swiss-Prot: APOA2_HUMAN, P02652

Tissue specificity: Plasma; synthesized in the liver and intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including APOA2:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOA2

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for APOA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for APOA2 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Apoa2^{1 , 5}	apolipoprotein A-II^{1, 5}	74.15(n)¹ 64.29(a)¹		1 (79.22 cM)⁵ 11807¹ NM_013474.2¹ NP_038502.2¹ 171225054⁵

ENSEMBL Gene Tree for APOA2 (if available)
TreeFam Gene Tree for APOA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76816717^1,2	C	--	132549026(+)	`CTCAGA/TGCTGG`	1	--	ds500¹		0	--	--	--	--
rs80268898^1,2	C	--	132549027(-)	`TCCAGA/C/GTCTGA`	1	--	ds500¹		1		CSA	1
rs75163218^1,2	C	--	132549028(-)	`ATCCAA/C/GCTCTG`	1	--	ds500¹		1		CSA	1
rs12824^1,2	C,H	--	132549204(-)	`CTGGAA/GCGGAA`	2	T A	mis¹ ese³		9		MN NS EA	812
rs1803091^1,2	C	--	132549227(-)	`GCTGAA/C/G/T ACCCC`	4	K T R I	mis¹ ese³		5		MN	408
rs76162486^1,2	C	--	132549260(+)	`AAGACC/TTGGAT`	1	--	spa¹		0	--	--	--	--
rs6413452^1,2	C,F,H,	--	132549381(-)	`CATGCG/AATGGA`	1	--	int¹		14		MN NS EA NA	1070
rs5087^1,2	C,H,	--	132549411(-)	`CTTGAC/TTCTAT`	1	--	int¹		13		MN NS EA	1272
rs5086^1,2	C,H	--	132549456(-)	`CTTSAA/TTTTCA`	1	--	int¹		11		MN NS EA	1078
rs5084^1,2	H	--	132549536(-)	`TTAAAT/ATGCAG`	1	--	int¹		5		MN NS EA	568

HapMap Linkage Disequilibrium report for APOA2 (161192082 - 161193421 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APOA2: --
Human Gene Mutation Database (HGMD): APOA2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOA2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

APOA2 for disorders           About GeneDecksing

OMIM gene information: 107670
OMIM disorders: 143890
20/57 diseases for APOA2 (see all 57):    About MalaCards

apolipoprotein a-ii deficiency hypercholesterolemia fish-eye disease hypercholesterolemia, familial, modification of

arcus senilis cetp deficiency familial combined hyperlipidemia hyperalphalipoproteinemia

hdl deficiency hypoalphalipoproteinemia coronary heart disease myocardial infarction

amyloidosis tangier disease hyperlipidemia hypertriglyceridemia

primary biliary cirrhosis carotid artery disease eye disease norum disease

8 diseases from the University of Copenhagen DISEASES database for APOA2:

Tangier disease Atherosclerosis Coronary heart disease Amyloidosis

Norum disease Familial hyperlipidemia Diabetes mellitus Arcus senilis

10/32 Novoseek disease relationships for APOA2 gene (see all 32) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fish-eye disease	77.8	3	8282802 (2)
tangier disease	77.1	2	8347683 (1), 8348751 (1)
hypoalphalipoproteinemia	75.6	2	7712672 (1), 12364558 (1)
lecithin cholesterol acyltransferase deficiency	74.8	2	8282802 (1)
lcat deficiency	72.4	6	8282802 (2), 10206431 (1), 8018670 (1)
hyperalphalipoproteinemia	67.2	1	8462178 (1)
hypertriglyceridemias familial	66.1	2	1907081 (2)
cetp deficiency	64.1	1	14657195 (1)
hyperlipidemia familial combined	56.1	3	15166779 (2), 15388641 (1)
hypertriglyceridemia	54.6	6	15466364 (1), 7989603 (1), 17709437 (1), 9001797 (1) (see all 5)

Genatlas disease: APOA2

apolipoprotein A-II deficiency

Genetic Association Database (GAD): APOA2
Human Genome Epidemiology (HuGE) Navigator: APOA2 (43 documents)

Export disorders for APOA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for APOA2 gene, integrated from 9 sources (see all 368):
(articles sorted by number of sources associating them with APOA2)

Utopia: connect your pdf to the dynamic
world of online information

Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample. (PubMed id 12136239)^{1, 2, 4} Fullerton S.M.... Nickerson D.A. (2002)
Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein. (PubMed id 12576517)^{1, 2, 9} Pankhurst G....Stocker R. (2003)
Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins. (PubMed id 12562854)^{1, 2, 9} Niederkofler E.E.... Nelson R.W. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24. (PubMed id 15922294)^{1, 2} Hunter M....Kalaydjieva L. (2005)
Apolipoprotein A-II polymorphism and visceral adiposity in African-American and white women. (PubMed id 15833935)^{1, 4} Lara-Castro C....Fernandez J.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Physical activity modulates effects of some genetic polymorphisms affecting cardiovascular risk in men aged over 40 years. (PubMed id 14650352)^{1, 4} Pisciotta L....Bertolini S. (2003)
Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. (PubMed id 11991719)^{1, 2} Ritter M....Schmitz G. (2002)
Structures of apolipoprotein A-II and a lipid-surrogate complex provide insights into apolipoprotein-lipid interactions. (PubMed id 12269810)^{1, 2} Kumar M.S.... Murthy H.M. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 336	HGNC: 601	AceView: APOA2	Ensembl:ENSG00000158874	euGenes: HUgn336
ECgene: APOA2	Kegg: 336	H-InvDB: APOA2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for APOA2	Pharmacogenomics, SNPs, Pathways
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA2

Intellectual Property for APOA2 gene
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Patent Information for APOA2 gene:
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Hypoalphalipoproteinemia
Hyperlipidemia Familial Combined
Coronary Artery Disease
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Shock
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Amyloid deposition
Hyperinsulinemia
Insulin Resistance
HYPERALPHALIPOPROTEINEMIA
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OBESITY
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RENAL AMYLOIDOSIS
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LECITHIN CHOLESTEROL ACYLTRANSFERASE DEFICIENCY
Polyneuropathy
LCAT deficiency
Atherosclerosis
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Hepatoblastoma
FISH-EYE DISEASE
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apolipoprotein A-II

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