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APOA1BP Gene

protein-coding   GIFtS: 59
GCID: GC01P156561

Apolipoprotein A-I Binding Protein

  Search for APOA1BP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein A-I Binding Protein1 2     YJEFN12 3
ApoA-I Binding Protein1 2     NAD(P)HX Epimerase2 3
Apolipoprotein A-I-Binding Protein2 3     NAD(P)H-Hydrate Epimerase2
YjeF N-Terminal Domain-Containing Protein 12 3     yjeF_N12
AI-BP2 3     EC 5.1.99.63
AIBP2 3     YjeF_N13

External Ids:    HGNC: 184531   Entrez Gene: 1282402   Ensembl: ENSG000001633827   OMIM: 6088625   UniProtKB: Q8NCW53   

Export aliases for APOA1BP gene to outside databases

Previous GC identifers: GC01P154430 GC01P152326 GC01P153339 GC01P153778 GC01P153374 GC01P154828 GC01P127919


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOA1BP Gene:
The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density
lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in
vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. (provided by RefSeq, Jul
2008)

GeneCards Summary for APOA1BP Gene:
APOA1BP (apolipoprotein A-I binding protein) is a protein-coding gene. GO annotations related to this gene include isomerase activity and protein homodimerization activity. An important paralog of this gene is YJEFN3.

UniProtKB/Swiss-Prot: NNRE_HUMAN, Q8NCW5
Function: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a
result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate
dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOA1BP gene promoter:
         USF1   STAT1   RFX1   AML1a   Pax-6   STAT1beta   STAT1alpha   CREB   deltaCREB   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOA1BP promoter sequence
   Search Chromatin IP Primers for APOA1BP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOA1BP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21

APOA1BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOA1BP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156561:  view genomic region     (about GC identifiers)

Start:
156,561,554 bp from pter      End:
156,564,091 bp from pter
Size:
2,538 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NNRE_HUMAN, Q8NCW5 (See protein sequence)
Recommended Name: NAD(P)H-hydrate epimerase precursor  
Size: 288 amino acids; 31675 Da
Cofactor: Binds 1 potassium ion per subunit (By similarity)
Subunit: Homodimer (By similarity). Interacts with APOA1 and APOA2
Secondary accessions: B4DGY3 Q496C6 Q5T3I2
Alternative splicing: 2 isoforms:  Q8NCW5-1   Q8NCW5-2   

Explore the universe of human proteins at neXtProt for APOA1BP: NX_Q8NCW5

Explore proteomics data for APOA1BP at MOPED

Post-translational modifications: 

  • Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation (By similarity)1
  • Ubiquitination2 at Lys132
  • Modification sites at PhosphoSitePlus

  • See APOA1BP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_658985.2  
    ENSEMBL proteins: 
     ENSP00000357217   ENSP00000357218   ENSP00000357216  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004443 YjeF_N_dom
     IPR026600 NnrE/AIBP

    Graphical View of Domain Structure for InterPro Entry Q8NCW5

    ProtoNet protein and cluster: Q8NCW5

    1 Blocks protein domain: IPB004443 YjeF-related protein

    UniProtKB/Swiss-Prot: NNRE_HUMAN, Q8NCW5
    Similarity: Belongs to the NnrE/AIBP family
    Similarity: Contains 1 YjeF N-terminal domain


    Find genes that share domains with APOA1BP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NNRE_HUMAN, Q8NCW5
    Function: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a
    result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate
    dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)
    Catalytic activity: (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide =
    (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
    Catalytic activity: (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate =
    (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate

         Enzyme Number (IUBMB): EC 5.1.99.61

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0005515protein binding IPI11991719
    GO:0016853isomerase activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with APOA1BP           About GenesLikeMe


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target APOA1BP:
    hsa-mir-20a-5p (MIRT050497)

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    2 qRT-PCR Assays for microRNAs that regulate APOA1BP:
    hsa-miR-1224-3p hsa-miR-1264
    SwitchGear 3'UTR luciferase reporter plasmidAPOA1BP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NNRE_HUMAN, Q8NCW5: Mitochondrion (By similarity). Secreted. Note=In sperm, secretion gradually increases during
    capacitation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion3
    cytosol2
    lysosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA11991719
    GO:0005615extracellular space ISS--
    GO:0005739mitochondrion IEA--
    GO:0005929cilium IEA--
    GO:0044297cell body IEA--

    Find genes that share ontologies with APOA1BP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APOA1BP About    
    See pathways by source

    SuperPathContained pathways About
    1NADH repair
    NADH repair


    1 BioSystems Pathway for APOA1BP
        NADH repair



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APOA1BP
    Interactions:

        GeneGlobe Interaction Network for APOA1BP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for APOA1BP (Q8NCW52, 3 ENSP000003572184) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8260702 I2D: score=2 
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    ALG6Q9Y6723, ENSP000003601494I2D: score=1 STRING: ENSP00000360149
    CARKDQ8IW453, ENSP000003119844I2D: score=1 STRING: ENSP00000311984
    APOA1P026473, ENSP000002368504I2D: score=2 STRING: ENSP00000236850
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0051289protein homotetramerization IEA--

    Find genes that share ontologies with APOA1BP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOA1BP (NNRE)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APOA1BP gene: 
    NM_144772.2  

    Unigene Cluster for APOA1BP:

    Apolipoprotein A-I binding protein
    Hs.528320  [show with all ESTs]
    Unigene Representative Sequence: AK123518
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368234 ENST00000368235(uc001fph.3 uc001fpi.3 uc001fpk.3 uc010php.1)
    ENST00000368233 ENST00000467374 ENST00000488840
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate APOA1BP:
    hsa-miR-1224-3p hsa-miR-1264
    SwitchGear 3'UTR luciferase reporter plasmidAPOA1BP 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat APOA1BP
      QuantiFast Probe-based Assays in human, mouse, rat APOA1BP

    Additional mRNA sequence: 

    AJ315849.1 AK123518.1 AK294835.1 AK298222.1 AK316083.1 BC056917.1 BC100931.1 BC100932.1 
    BC100933.1 BC100934.2 

    15 DOTS entries:

    DT.85105628  DT.114776  DT.100781784  DT.40109623  DT.101983816  DT.121345389  DT.95191151  DT.100698079 
    DT.100781786  DT.95191136  DT.95191137  DT.95191149  DT.121345338  DT.92435093  DT.434968 

    Selected AceView cDNA sequences (see all 210):

    CR606473 CR597550 BM833895 AA130163 AA448118 CR620453 BM700595 BM826821 
    CR606563 CR593423 BE781125 CB123166 AA099926 BQ636200 BV187302 AA513482 
    BG686444 CA438685 AI299681 AW005775 BQ028042 CA420970 BQ017155 AL556590 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for APOA1BP (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c
    SP1:                                                        -     -           -     -                     
    SP2:                                                        -                 -     -                     
    SP3:                                                        -                 -     -                     
    SP4:                                                        -                                             
    SP5:                                                        -                 -     -                     


    ECgene alternative splicing isoforms for APOA1BP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOA1BP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGATTGATG
    APOA1BP Expression
    About this image


    APOA1BP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    APOA1BP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOA1BP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528320

    UniProtKB/Swiss-Prot: NNRE_HUMAN, Q8NCW5
    Tissue specificity: Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in
    cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at
    protein level)

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    QuantiFast Probe-based Assays in human, mouse, rat APOA1BP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOA1BP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for APOA1BP gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apoa1bp1 , 5 apolipoprotein A-I binding protein1, 5 85.21(n)1
    89.85(a)1
      3 (38.78 cM)5
    2467031  NM_144897.31  NP_659146.11 
     880565235 
    lizard
    (Anolis carolinensis)
    Reptilia APOA1BP6
    apolipoprotein A-I binding protein
    66(a)
    1 ↔ 1
    GL345062.1(1975-7741)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168012 Xenopus laevis transcribed sequence with weak similarity more 75.91(n)    BX853119.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ262511.12   -- 75.73(n)    BQ262511.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29741 , 3 CG29741 53(a)3
    61.65(n)1
    61.95(a)1
      9B13
    319441  NM_132376.21  NP_572604.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y18D10A.33
    CELE_Y18D10A.31
    CELE_Y18D10A.31 44(a)3
    51.69(n)1
    47.58(a)1
      I(12818221-12823693)3
    1894721  NM_060840.11  NP_493241.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YNL200C)4
    YNL200C1
    Putative protein of unknown function; the authentic, more4
    YNL200C1
    46.92(n)1
    42.49(a)1
      14(264453-263713)4
    8555211, 4  NP_014199.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PPOX1 PPOX 52.21(n)
    54.42(a)
      835061  NM_124376.3  NP_568717.2 
    rice
    (Oryza sativa)
    Liliopsida Os.167852 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.31(n)    AK099380.1 


    ENSEMBL Gene Tree for APOA1BP (if available)
    TreeFam Gene Tree for APOA1BP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for APOA1BP gene
    YJEFN32  
    1 SIMAP similar gene for APOA1BP using alignment to 4 protein entries:     NNRE_HUMAN (see all proteins):
    YJEFN3

    Find genes that share paralogs with APOA1BP           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for APOA1BP
    PGOHUM00000234538 PGOHUM00000235857


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APOA1BP (see all 135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429033161,2
    --156559604(+) GAGGTC/TAGAGC 1 -- us2k10--------
    rs1862058081,2
    --156559612(+) AGCACC/TCTTCT 1 -- us2k10--------
    rs1412550021,2
    C--156559645(+) TTTTC-/TTTTTTTT 1 -- cds10--------
    rs612149191,2
    C--156559655(+) TTTTTTTT/-GGGGG 1 -- cds11Minor allele frequency- -:0.00NA 2
    rs1905790821,2
    --156559658(+) TTTGGG/TGGGGG 1 -- us2k10--------
    rs101275511,2
    C,F--156559659(+) ttgggG/Aggggg 1 -- us2k1 tfbs3 trp38Minor allele frequency- A:0.45NA WA EA 368
    rs596355581,2
    C--156559660(+) TGGGGG/TGGGGG 1 -- us2k14Minor allele frequency- T:0.24WA NA EA 360
    rs1466372481,2
    C--156559701(+) AGTGCA/GGTGGC 1 -- us2k10--------
    rs1414774621,2
    C--156559814(+) GCTAAC/TTTTTT 1 -- us2k10--------
    rs1828213391,2
    --156560135(+) GCCAGA/GCTGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for APOA1BP (156561554 - 156564091 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for APOA1BP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872472CNV Loss21882294
    nsv523181CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOA1BP
    DNA2.0 Custom Variant and Variant Library Synthesis for APOA1BP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608862    OMIM disorders: --


    Find genes that share disorders with APOA1BP           About GenesLikeMe

    Genetic Association Database (GAD): APOA1BP
    Human Genome Epidemiology (HuGE) Navigator: APOA1BP (3 documents)

    Export disorders for APOA1BP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOA1BP gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with APOA1BP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. (PubMed id 11991719)1, 2, 3, 9 Ritter M....Schmitz G. (Genomics 2002)
    2. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PubMed id 17533573)1, 3, 9 Rudolph C.... Schmitz G. (Horm. Metab. Res. 2007)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PubMed id 20855565)1, 4 Peloso G.M....Brousseau M.E. (J. Lipid Res. 2010)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PubMed id 23793025)1 Anttila V.... . (Nat. Genet. 2013)
    7. Control of angiogenesis by AIBP-mediated cholesterol efflux. (PubMed id 23719382)1 Fang L....Miller Y.I. (Nature 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (J. Proteome Res. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 128240 HGNC: 18453 AceView: APOA1BP Ensembl:ENSG00000163382 euGenes: HUgn128240
    ECgene: APOA1BP H-InvDB: APOA1BP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APOA1BP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APOA1BP gene:
    Search GeneIP for patents involving APOA1BP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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