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Aliases for APOA1BP Gene

Aliases for APOA1BP Gene

  • Apolipoprotein A-I Binding Protein 2 3
  • YjeF N-Terminal Domain-Containing Protein 1 3 4
  • Apolipoprotein A-I-Binding Protein 3 4
  • ApoA-I Binding Protein 2 3
  • NAD(P)HX Epimerase 3 4
  • YjeF_N1 3 4
  • YJEFN1 3 4
  • AI-BP 3 4
  • AIBP 3 4
  • NAD(P)H-Hydrate Epimerase 3
  • EC 4

External Ids for APOA1BP Gene

Previous GeneCards Identifiers for APOA1BP Gene

  • GC01P154430
  • GC01P152326
  • GC01P153339
  • GC01P153778
  • GC01P153374
  • GC01P154828
  • GC01P127919

Summaries for APOA1BP Gene

Entrez Gene Summary for APOA1BP Gene

  • The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOA1BP Gene

APOA1BP (Apolipoprotein A-I Binding Protein) is a Protein Coding gene. Among its related pathways are NADH repair. GO annotations related to this gene include protein homodimerization activity and isomerase activity. An important paralog of this gene is YJEFN3.

UniProtKB/Swiss-Prot for APOA1BP Gene

  • Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA1BP Gene

Genomics for APOA1BP Gene

Regulatory Elements for APOA1BP Gene

Genomic Location for APOA1BP Gene

156,591,762 bp from pter
156,594,299 bp from pter
2,538 bases
Plus strand

Genomic View for APOA1BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOA1BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA1BP Gene

Proteins for APOA1BP Gene

  • Protein details for APOA1BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NAD(P)H-hydrate epimerase
    Protein Accession:
    Secondary Accessions:
    • B4DGY3
    • Q496C6
    • Q5T3I2

    Protein attributes for APOA1BP Gene

    288 amino acids
    Molecular mass:
    31675 Da
    Name=K(+); Xref=ChEBI:CHEBI:29103; Note=Binds 1 potassium ion per subunit.;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with APOA1 and APOA2.

    Alternative splice isoforms for APOA1BP Gene


neXtProt entry for APOA1BP Gene

Proteomics data for APOA1BP Gene at MOPED

Post-translational modifications for APOA1BP Gene

  • Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.
  • Ubiquitination at Lys132
  • Modification sites at PhosphoSitePlus

Other Protein References for APOA1BP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOA1BP Gene

Domains for APOA1BP Gene

Protein Domains for APOA1BP Gene


Suggested Antigen Peptide Sequences for APOA1BP Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8NCW5
  • Contains 1 YjeF N-terminal domain.
  • Belongs to the NnrE/AIBP family.
genes like me logo Genes that share domains with APOA1BP: view

No data available for Gene Families for APOA1BP Gene

Function for APOA1BP Gene

Molecular function for APOA1BP Gene

UniProtKB/Swiss-Prot CatalyticActivity: (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
UniProtKB/Swiss-Prot CatalyticActivity: (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
UniProtKB/Swiss-Prot Function: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Enzyme Numbers (IUBMB) for APOA1BP Gene

Gene Ontology (GO) - Molecular Function for APOA1BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 11991719
GO:0042803 protein homodimerization activity IEA --
GO:0046872 metal ion binding IEA --
GO:0052856 NADHX epimerase activity IBA --
genes like me logo Genes that share ontologies with APOA1BP: view

miRNA for APOA1BP Gene

miRTarBase miRNAs that target APOA1BP

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for APOA1BP Gene

Localization for APOA1BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA1BP Gene

Mitochondrion. Secreted. Note=In sperm, secretion gradually increases during capacitation. {ECO:0000255 HAMAP-Rule:MF_03159}.

Subcellular locations from

Jensen Localization Image for APOA1BP Gene COMPARTMENTS Subcellular localization image for APOA1BP gene
Compartment Confidence
extracellular 5
mitochondrion 3
cytosol 2
lysosome 1

Gene Ontology (GO) - Cellular Components for APOA1BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 11991719
GO:0005615 extracellular space ISS 22261194
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with APOA1BP: view

Pathways for APOA1BP Gene

SuperPathways for APOA1BP Gene

Superpath Contained pathways
1 NADH repair
genes like me logo Genes that share pathways with APOA1BP: view

Pathways by source for APOA1BP Gene

1 BioSystems pathway for APOA1BP Gene

Gene Ontology (GO) - Biological Process for APOA1BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006734 NADH metabolic process IBA --
GO:0006739 NADP metabolic process IBA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process --
GO:0051289 protein homotetramerization IEA --
genes like me logo Genes that share ontologies with APOA1BP: view

Transcripts for APOA1BP Gene

Unigene Clusters for APOA1BP Gene

Apolipoprotein A-I binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOA1BP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - - - -

Relevant External Links for APOA1BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOA1BP Gene

mRNA expression in normal human tissues for APOA1BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APOA1BP Gene

SOURCE GeneReport for Unigene cluster for APOA1BP Gene Hs.528320

mRNA Expression by UniProt/SwissProt for APOA1BP Gene

Tissue specificity: Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level).
genes like me logo Genes that share expressions with APOA1BP: view

No data available for mRNA differential expression in normal tissues for APOA1BP Gene

Orthologs for APOA1BP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for APOA1BP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APOA1BP 35
  • 99.54 (n)
  • 99.31 (a)
  • 99 (a)
(Bos Taurus)
Mammalia APOA1BP 35
  • 90.56 (n)
  • 90.81 (a)
  • 91 (a)
(Canis familiaris)
Mammalia APOA1BP 35
  • 85.91 (n)
  • 87.5 (a)
  • 73 (a)
(Mus musculus)
Mammalia Apoa1bp 35
  • 85.21 (n)
  • 89.85 (a)
Apoa1bp 16
Apoa1bp 36
  • 89 (a)
(Monodelphis domestica)
Mammalia APOA1BP 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia APOA1BP 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Apoa1bp 35
  • 87.15 (n)
  • 95.12 (a)
(Anolis carolinensis)
Reptilia APOA1BP 36
  • 66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16801 35
tropical clawed frog
(Silurana tropicalis)
Amphibia apoa1bp 35
  • 70.27 (n)
  • 78.79 (a)
(Danio rerio)
Actinopterygii apoa1bp 35
  • 65.8 (n)
  • 69.78 (a)
apoa1bp 36
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003324 35
  • 56.64 (n)
  • 57.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2974 35
  • 61.65 (n)
  • 61.95 (a)
CG2974 36
  • 60 (a)
CG2974 37
  • 53 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y18D10A.3 35
  • 51.69 (n)
  • 47.58 (a)
Y18D10A.3 36
  • 32 (a)
Y18D10A.3 37
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL161C 35
  • 51.17 (n)
  • 45.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 40 (a)
-- 38
YNL200C 35
  • 46.92 (n)
  • 42.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20768g 35
  • 49.85 (n)
  • 52.23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PPOX 35
  • 52.21 (n)
  • 54.42 (a)
(Oryza sativa)
Liliopsida Os.16785 35
Os10g0377800 35
  • 57.14 (n)
  • 55.8 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08070 35
  • 52.85 (n)
  • 49.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug182 35
  • 50.37 (n)
  • 49.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2106 35
Species with no ortholog for APOA1BP:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APOA1BP Gene

Gene Tree for APOA1BP (if available)
Gene Tree for APOA1BP (if available)

Paralogs for APOA1BP Gene

Paralogs for APOA1BP Gene

Selected SIMAP similar genes for APOA1BP Gene using alignment to 4 proteins: Pseudogenes for APOA1BP Gene

genes like me logo Genes that share paralogs with APOA1BP: view

Variants for APOA1BP Gene

Sequence variations from dbSNP and Humsavar for APOA1BP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs942959 -- 156,592,351(+) CCCTT(A/G)ACTCT intron-variant
rs942960 -- 156,593,138(+) GAATC(C/T)GGCTC intron-variant
rs942961 -- 156,593,189(+) AGTGG(C/T)GGGCA intron-variant
rs942962 -- 156,593,233(+) TCTCA(A/G)TTTGG intron-variant
rs1925949 -- 156,592,216(+) TCAGT(A/G)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOA1BP Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV Loss 19592680
nsv872472 CNV Loss 21882294

Relevant External Links for APOA1BP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOA1BP Gene

Disorders for APOA1BP Gene

Relevant External Links for APOA1BP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with APOA1BP: view

No data available for UniProtKB/Swiss-Prot for APOA1BP Gene

Publications for APOA1BP Gene

  1. Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. (PMID: 11991719) Ritter M. … Schmitz G. (Genomics 2002) 2 3 4 23
  2. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PMID: 17533573) Rudolph C. … Schmitz G. (Horm. Metab. Res. 2007) 2 3 23
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  4. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso G.M. … Brousseau M.E. (J. Lipid Res. 2010) 3 48
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for APOA1BP Gene

Sources for APOA1BP Gene

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