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Aliases for APOA1 Gene

Aliases for APOA1 Gene

  • Apolipoprotein A-I 2 3
  • Apo-AI 3 4
  • Apolipoprotein A1 4
  • ApoA-I 4

External Ids for APOA1 Gene

Previous GeneCards Identifiers for APOA1 Gene

  • GC11M119059
  • GC11M118218
  • GC11M116740
  • GC11M116244
  • GC11M116211
  • GC11M116706
  • GC11M112638

Summaries for APOA1 Gene

Entrez Gene Summary for APOA1 Gene

  • This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOA1 Gene

APOA1 (Apolipoprotein A-I) is a Protein Coding gene. Diseases associated with APOA1 include apolipoprotein a-i deficiency and aapoai amyloidosis. Among its related pathways are Signaling by GPCR and Hemostasis. GO annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is APOA4.

UniProtKB/Swiss-Prot for APOA1 Gene

  • Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Gene Wiki entry for APOA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA1 Gene

Genomics for APOA1 Gene

Regulatory Elements for APOA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APOA1 Gene

Chromosome:
11
Start:
116,835,751 bp from pter
End:
116,837,950 bp from pter
Size:
2,200 bases
Orientation:
Minus strand

Genomic View for APOA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA1 Gene

Proteins for APOA1 Gene

  • Protein details for APOA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02647-APOA1_HUMAN
    Recommended name:
    Apolipoprotein A-I
    Protein Accession:
    P02647
    Secondary Accessions:
    • A8K866
    • Q6LDN9
    • Q6Q785
    • Q9UCS8
    • Q9UCT8

    Protein attributes for APOA1 Gene

    Size:
    267 amino acids
    Molecular mass:
    30778 Da
    Quaternary structure:
    • Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1.

    Three dimensional structures from OCA and Proteopedia for APOA1 Gene

neXtProt entry for APOA1 Gene

Proteomics data for APOA1 Gene at MOPED

Post-translational modifications for APOA1 Gene

Other Protein References for APOA1 Gene

Antibody Products

  • R&D Systems Antibodies for APOA1 (Apolipoprotein A-I/ApoA1)
  • Cell Signaling Technology (CST) Antibodies for APOA1 (APOA1)

Protein Products

No data available for DME Specific Peptides for APOA1 Gene

Domains & Families for APOA1 Gene

Gene Families for APOA1 Gene

Protein Domains for APOA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02647

UniProtKB/Swiss-Prot:

APOA1_HUMAN :
  • Belongs to the apolipoprotein A1/A4/E family.
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOA1: view

Function for APOA1 Gene

Molecular function for APOA1 Gene

GENATLAS Biochemistry:
apolipoprotein A-I (see HDLA@),major protein of HDL,involved in the reverse transport of cholesterol from tissues to liver
UniProtKB/Swiss-Prot Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Gene Ontology (GO) - Molecular Function for APOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IDA 11297421
GO:0005319 lipid transporter activity --
GO:0005515 protein binding IPI 11297421
GO:0005543 phospholipid binding IDA 12810715
GO:0005548 phospholipid transporter activity IEA --
genes like me logo Genes that share ontologies with APOA1: view
genes like me logo Genes that share phenotypes with APOA1: view

Animal Models for APOA1 Gene

MGI Knock Outs for APOA1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for APOA1 Gene

Localization for APOA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA1 Gene COMPARTMENTS Subcellular localization image for APOA1 gene
Compartment Confidence
extracellular 5
cytosol 4
endoplasmic reticulum 4
endosome 4
plasma membrane 4
nucleus 2
peroxisome 2
cytoskeleton 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for APOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS 22261194
GO:0005634 nucleus IEA --
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with APOA1: view

Pathways & Interactions for APOA1 Gene

genes like me logo Genes that share pathways with APOA1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for APOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0001935 endothelial cell proliferation IEA --
GO:0002576 platelet degranulation TAS --
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA 12458630
genes like me logo Genes that share ontologies with APOA1: view

No data available for SIGNOR curated interactions for APOA1 Gene

Drugs & Compounds for APOA1 Gene

(73) Drugs for APOA1 Gene - From: NovoSeek, DGIdb, HMDB, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fenofibrate Approved Pharma PPARalpha agonist 158
Aspirin Approved Pharma Channel blocker 971
Atenolol Approved Pharma Antagonist 98
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Bezafibrate Approved Pharma Agonist 11

(52) Additional Compounds for APOA1 Gene - From: NovoSeek and HMDB