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Aliases for APOA1 Gene

Aliases for APOA1 Gene

  • Apolipoprotein A1 2 3 4 5
  • Apolipoprotein A-I 2 3
  • Apo-AI 3 4
  • Apo(A) 3
  • ApoA-I 4

External Ids for APOA1 Gene

Previous GeneCards Identifiers for APOA1 Gene

  • GC11M119059
  • GC11M118218
  • GC11M116740
  • GC11M116244
  • GC11M116211
  • GC11M116706
  • GC11M112638

Summaries for APOA1 Gene

Entrez Gene Summary for APOA1 Gene

  • This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]

GeneCards Summary for APOA1 Gene

APOA1 (Apolipoprotein A1) is a Protein Coding gene. Diseases associated with APOA1 include Amyloidosis, Familial Visceral and Hypoalphalipoproteinemia. Among its related pathways are Metabolism of fat-soluble vitamins and Statin Pathway. GO annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is APOA4.

UniProtKB/Swiss-Prot for APOA1 Gene

  • Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Gene Wiki entry for APOA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA1 Gene

Genomics for APOA1 Gene

Regulatory Elements for APOA1 Gene

Enhancers for APOA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F116825 1.6 FANTOM5 Ensembl ENCODE 35.6 +4.5 4545 16.6 HDGF PKNOX1 MLX ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS APOA5 APOA1 LOC653303 APOC3 TAGLN ZPR1 BUD13 LOC105369514 ENSG00000224077 SIK3
GH11F116807 1.3 FANTOM5 ENCODE 28.2 +29.3 29309 1.9 PKNOX1 ATF1 MLX DMAP1 YY1 SP5 MIER2 PPARG KAT8 SSRP1 APOA1 LOC653303 LOC105369514 BUD13 SIK3 ENSG00000224077 ENSG00000254678 PAFAH1B2 PCSK7 RNF214
GH11F116924 1.6 FANTOM5 Ensembl ENCODE 16.2 -91.4 -91365 9.8 PKNOX1 CBX3 RAD21 RARA YY1 SCRT2 CREM CBFB JUNB TBX21 LOC653303 APOA1 SIK3 ENSG00000224077 PCSK7 TAGLN GC11P117017
GH11F116978 1.6 FANTOM5 Ensembl ENCODE 16.2 -147.2 -147184 12.5 HDGF PKNOX1 ATF1 ZNF133 SIN3A FEZF1 ZNF2 ZNF48 YY1 ZNF766 LOC653303 SIK3 APOA1 ENSG00000224077 TAGLN BUD13 LOC105369514 PCSK7 RNF214 SIDT2
GH11F116851 1.5 FANTOM5 Ensembl ENCODE 16.4 -15.5 -15508 4.9 HDGF WRNIP1 FEZF1 KLF7 FOS YY2 JUNB TSHZ1 ZNF488 TBX21 LOC653303 SIK3 APOA1 APOC3 APOA4 ENSG00000236267 APOA5 ZPR1 ENSG00000224077 LOC105369514
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOA1 on UCSC Golden Path with GeneCards custom track

Promoters for APOA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000112174 1950 801 HDGF ARID4B ZNF48 ZNF2 ZNF143 PAF1 REST ZNF610 SMARCA4 GLIS1

Genomic Location for APOA1 Gene

Chromosome:
11
Start:
116,835,751 bp from pter
End:
116,837,950 bp from pter
Size:
2,200 bases
Orientation:
Minus strand

Genomic View for APOA1 Gene

Genes around APOA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA1 Gene

Proteins for APOA1 Gene

  • Protein details for APOA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02647-APOA1_HUMAN
    Recommended name:
    Apolipoprotein A-I
    Protein Accession:
    P02647
    Secondary Accessions:
    • A8K866
    • Q6LDN9
    • Q6Q785
    • Q9UCS8
    • Q9UCT8

    Protein attributes for APOA1 Gene

    Size:
    267 amino acids
    Molecular mass:
    30778 Da
    Quaternary structure:
    • Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1.

    Three dimensional structures from OCA and Proteopedia for APOA1 Gene

neXtProt entry for APOA1 Gene

Post-translational modifications for APOA1 Gene

Antibody Products

  • R&D Systems Antibodies for APOA1 (Apolipoprotein A-I/ApoA1)
  • Cell Signaling Technology (CST) Antibodies for APOA1 (APOA1)

Protein Products

No data available for DME Specific Peptides for APOA1 Gene

Domains & Families for APOA1 Gene

Gene Families for APOA1 Gene

Protein Domains for APOA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02647

UniProtKB/Swiss-Prot:

APOA1_HUMAN :
  • Belongs to the apolipoprotein A1/A4/E family.
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOA1: view

Function for APOA1 Gene

Molecular function for APOA1 Gene

GENATLAS Biochemistry:
apolipoprotein A-I (see HDLA@),major protein of HDL,involved in the reverse transport of cholesterol from tissues to liver
UniProtKB/Swiss-Prot Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Gene Ontology (GO) - Molecular Function for APOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IDA 11297421
GO:0005319 lipid transporter activity IEA --
GO:0005515 protein binding IPI 11297421
GO:0005543 phospholipid binding IDA 12810715
GO:0005548 phospholipid transporter activity IEA --
genes like me logo Genes that share ontologies with APOA1: view
genes like me logo Genes that share phenotypes with APOA1: view

Human Phenotype Ontology for APOA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for APOA1 Gene

MGI Knock Outs for APOA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for APOA1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for APOA1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for APOA1 Gene

Localization for APOA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOA1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
cytosol 5
endosome 5
nucleus 3
peroxisome 2
lysosome 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for APOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,ISS 22261194
GO:0005634 nucleus IEA --
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with APOA1: view

Pathways & Interactions for APOA1 Gene

genes like me logo Genes that share pathways with APOA1: view

Gene Ontology (GO) - Biological Process for APOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0001935 endothelial cell proliferation IEA --
GO:0002576 platelet degranulation TAS --
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA 12458630
genes like me logo Genes that share ontologies with APOA1: view

No data available for SIGNOR curated interactions for APOA1 Gene

Drugs & Compounds for APOA1 Gene

(75) Drugs for APOA1 Gene - From: PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fenofibrate Approved Pharma 169
cholesterol Experimental Pharma Agonist 0
CER-001 Pharma 0
RVX-208 Pharma Potent BET bromodomain inhibitor 0

(50) Additional Compounds for APOA1 Gene - From: Novoseek and HMDB