External Ids for APOA1 Gene
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOA1 Gene
APOA1 (Apolipoprotein A-I) is a Protein Coding gene. Diseases associated with APOA1 include apo a-i deficiency and cerebral atherosclerosis. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include identical protein binding and enzyme binding. An important paralog of this gene is APOA4.
UniProtKB/Swiss-Prot for APOA1 Gene
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.