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Aliases for APOA1 Gene

Aliases for APOA1 Gene

  • Apolipoprotein A1 2 4
  • Apolipoprotein A-I 2 3 5
  • Apo-AI 3 4
  • Apo(A) 3
  • ApoA-I 4

External Ids for APOA1 Gene

Previous GeneCards Identifiers for APOA1 Gene

  • GC11M119059
  • GC11M118218
  • GC11M116740
  • GC11M116244
  • GC11M116211
  • GC11M116706
  • GC11M112638

Summaries for APOA1 Gene

Entrez Gene Summary for APOA1 Gene

  • This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]

GeneCards Summary for APOA1 Gene

APOA1 (Apolipoprotein A1) is a Protein Coding gene. Diseases associated with APOA1 include amyloidosis, familial visceral and hypoalphalipoproteinemia. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is APOA4.

UniProtKB/Swiss-Prot for APOA1 Gene

  • Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Gene Wiki entry for APOA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOA1 Gene

Genomics for APOA1 Gene

Regulatory Elements for APOA1 Gene

Promoters for APOA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOA1 Gene

Chromosome:
11
Start:
116,835,751 bp from pter
End:
116,837,950 bp from pter
Size:
2,200 bases
Orientation:
Minus strand

Genomic View for APOA1 Gene

Genes around APOA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOA1 Gene

Proteins for APOA1 Gene

  • Protein details for APOA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02647-APOA1_HUMAN
    Recommended name:
    Apolipoprotein A-I
    Protein Accession:
    P02647
    Secondary Accessions:
    • A8K866
    • Q6LDN9
    • Q6Q785
    • Q9UCS8
    • Q9UCT8

    Protein attributes for APOA1 Gene

    Size:
    267 amino acids
    Molecular mass:
    30778 Da
    Quaternary structure:
    • Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1.

    Three dimensional structures from OCA and Proteopedia for APOA1 Gene

neXtProt entry for APOA1 Gene

Proteomics data for APOA1 Gene at MOPED

Post-translational modifications for APOA1 Gene

Antibody Products

  • R&D Systems Antibodies for APOA1 (Apolipoprotein A-I/ApoA1)
  • Cell Signaling Technology (CST) Antibodies for APOA1 (APOA1)

Protein Products

No data available for DME Specific Peptides for APOA1 Gene

Domains & Families for APOA1 Gene

Gene Families for APOA1 Gene

Protein Domains for APOA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02647

UniProtKB/Swiss-Prot:

APOA1_HUMAN :
  • Belongs to the apolipoprotein A1/A4/E family.
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOA1: view

Function for APOA1 Gene

Molecular function for APOA1 Gene

GENATLAS Biochemistry:
apolipoprotein A-I (see HDLA@),major protein of HDL,involved in the reverse transport of cholesterol from tissues to liver
UniProtKB/Swiss-Prot Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

Gene Ontology (GO) - Molecular Function for APOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008035 high-density lipoprotein particle binding IEA --
GO:0017127 cholesterol transporter activity IEA,IMP 15464323
GO:0070653 high-density lipoprotein particle receptor binding IPI 10764676
genes like me logo Genes that share ontologies with APOA1: view
genes like me logo Genes that share phenotypes with APOA1: view

Human Phenotype Ontology for APOA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for APOA1 Gene

MGI Knock Outs for APOA1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for APOA1 Gene

Localization for APOA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOA1 Gene COMPARTMENTS Subcellular localization image for APOA1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
endosome 5
extracellular 5
plasma membrane 5
nucleus 3
peroxisome 2
cytoskeleton 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for APOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,ISS 22261194
GO:0005769 early endosome TAS --
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with APOA1: view

Pathways & Interactions for APOA1 Gene

genes like me logo Genes that share pathways with APOA1: view

Gene Ontology (GO) - Biological Process for APOA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0002576 platelet degranulation TAS --
GO:0006644 phospholipid metabolic process IEA --
GO:0006656 phosphatidylcholine biosynthetic process IDA 4335615
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with APOA1: view

No data available for SIGNOR curated interactions for APOA1 Gene

Drugs & Compounds for APOA1 Gene

(73) Drugs for APOA1 Gene - From: Novoseek, DGIdb, HMDB, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fenofibrate Approved Pharma PPARalpha agonist 160
cholesterol Experimental Pharma Agonist 0
CER-001 Pharma 0
RVX-208 Pharma Potent BET bromodomain inhibitor 0

(52) Additional Compounds for APOA1 Gene - From: Novoseek and HMDB