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APMAP Gene(Protein Coding)

Adipocyte Plasma Membrane Associated Protein

GCID:
GC20M024945
GIFtS:
51
Genes Participants
UDN Logo

Aliases for APMAP Gene

Aliases for APMAP Gene

  • Adipocyte Plasma Membrane Associated Protein 2 3 5
  • Protein BSCv 3 4
  • C20orf3 3 4
  • Chromosome 20 Open Reading Frame 3 2
  • BSCv 3

External Ids for APMAP Gene

Previous HGNC Symbols for APMAP Gene

  • C20orf3

Summaries for APMAP Gene

GeneCards Summary for APMAP Gene

APMAP (Adipocyte Plasma Membrane Associated Protein) is a Protein Coding gene. GO annotations related to this gene include arylesterase activity and strictosidine synthase activity.

UniProtKB/Swiss-Prot for APMAP Gene

  • Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.

Gene Wiki entry for APMAP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APMAP Gene

Genomics for APMAP Gene

Products:

  1. Regulatory Element

Regulatory Elements for APMAP Gene

Enhancers for APMAP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APMAP on UCSC Golden Path with GeneCards custom track

Promoters for APMAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APMAP on UCSC Golden Path with GeneCards custom track

Genomic Location for APMAP Gene

Chromosome:
20
Start:
24,962,925 bp from pter
End:
24,992,979 bp from pter
Size:
30,055 bases
Orientation:
Minus strand

Genomic View for APMAP Gene

Genes around APMAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APMAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APMAP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for APMAP Gene

Proteins for APMAP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for APMAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HDC9-APMAP_HUMAN
    Recommended name:
    Adipocyte plasma membrane-associated protein
    Protein Accession:
    Q9HDC9
    Secondary Accessions:
    • A8K514
    • B4DXG1
    • Q6UVZ8
    • Q9GZS8
    • Q9NUB2

    Protein attributes for APMAP Gene

    Size:
    416 amino acids
    Molecular mass:
    46480 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89435.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB11885.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15253.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15578.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for APMAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APMAP Gene

Proteomics data for APMAP Gene at MOPED

Protein Expression for APMAP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for APMAP Gene

  • Ubiquitination at Lys 123, Lys 179, and Lys 220
  • Glycosylation at Asn 160 and Asn 196
  • Modification sites at PhosphoSitePlus

Other Protein References for APMAP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for APMAP

No data available for DME Specific Peptides for APMAP Gene

Domains & Families for APMAP Gene

Protein Domains for APMAP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APMAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HDC9

UniProtKB/Swiss-Prot:

APMAP_HUMAN :
  • Belongs to the strictosidine synthase family.
Family:
  • Belongs to the strictosidine synthase family.
genes like me logo Genes that share domains with APMAP: view

No data available for Gene Families for APMAP Gene

Function for APMAP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for APMAP Gene

UniProtKB/Swiss-Prot Function:
Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.

Phenotypes for APMAP Gene

GenomeRNAi human phenotypes for APMAP:
genes like me logo Genes that share phenotypes with APMAP: view

Animal Model Products

miRNA for APMAP Gene

miRTarBase miRNAs that target APMAP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APMAP Gene

Localization for APMAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for APMAP Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APMAP Gene COMPARTMENTS Subcellular localization image for APMAP gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 3
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APMAP: view

Pathways & Interactions for APMAP Gene

SuperPathways for APMAP Gene

PathCards logoMore details on SuperPathways for APMAP
No Data Available

Interacting Proteins for APMAP Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000217456%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000362931%0d%0a9606.ENSP00000339917%0d%0a9606.ENSP00000217893%0d%0a9606.ENSP00000250495%0d%0a
Selected Interacting proteins: Q9HDC9-APMAP_HUMAN ENSP00000217456 for APMAP Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for APMAP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for APMAP Gene

Drugs & Compounds for APMAP Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for APMAP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for APMAP Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(696) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APMAP Gene

Adipocyte plasma membrane associated protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APMAP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for APMAP Gene

GeneLoc Exon Structure for
APMAP
ECgene alternative splicing isoforms for
APMAP

Expression for APMAP Gene

Products:

  1. Primer

mRNA expression in normal human tissues for APMAP Gene

mRNA expression in normal human tissues for APMAP Gene
mRNA expression by BioGPS for APMAP GenemRNA expression by GTEx for APMAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APMAP Gene

This gene is overexpressed in Whole Blood (x7.6) and Liver (x4.9).

Protein differential expression in normal tissues from HIPED for APMAP Gene

This gene is overexpressed in Nasal epithelium (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for APMAP Gene



SOURCE GeneReport for Unigene cluster for APMAP Gene Hs.472330

mRNA Expression by UniProt/SwissProt for APMAP Gene

Q9HDC9-APMAP_HUMAN
Tissue specificity: Liver, glomerular and tubular structures of the kidney, endothelial cells, arterial wall and pancreatic islets of Langerhans (at protein level). Found ubiquitously in adult as well as in embryonic tissues. In adult tissue, the highest expression is found in the liver, placenta and heart. Found on the cell surface of monocytes. In embryonic tissue, the highest expression levels is found in the liver and the kidney.
genes like me logo Genes that share expression patterns with APMAP: view

Protein tissue co-expression partners for APMAP Gene

Primer Products

Orthologs for APMAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for APMAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia APMAP 35
  • 84.39 (n)
  • 86.65 (a)
APMAP 36
  • 87 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia APMAP 35
  • 89.08 (n)
  • 91.08 (a)
APMAP 36
  • 91 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Apmap 35
  • 86.59 (n)
  • 89.64 (a)
Apmap 16
Apmap 36
  • 89 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia APMAP 35
  • 99.52 (n)
  • 99.28 (a)
C20H20ORF3 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Apmap 35
  • 86.08 (n)
  • 88.83 (a)
oppossum
(Monodelphis domestica)
 Mammalia APMAP 36
  • 82 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 85 (a)
 OneToMany
-- 36
  • 65 (a)
 OneToMany
-- 36
  • 74 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves C3H20ORF3 35
  • 71.81 (n)
  • 75.66 (a)
APMAP 36
  • 76 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia APMAP 36
  • 74 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100485177 35
  • 67.47 (n)
  • 69.4 (a)
Str.3092 35
zebrafish
(Danio rerio)
 Actinopterygii apmap 35
  • 64.1 (n)
  • 64.82 (a)
Dr.99 35
apmap 36
  • 65 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP004065 35
  • 45.7 (n)
  • 38.87 (a)
fruit fly
(Drosophila melanogaster)
 Insecta Hmu 35
  • 46.04 (n)
  • 37.8 (a)
Hmu 36
  • 22 (a)
 OneToMany
Ssl2 36
  • 30 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea CELE_C08E8.2 35
  • 47.18 (n)
  • 38.02 (a)
C08E8.2 36
  • 35 (a)
 OneToMany
F57C2.5 36
  • 34 (a)
 OneToMany
T12G3.4 36
  • 29 (a)
 OneToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT3G57030 35
  • 47.54 (n)
  • 40.27 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 29 (a)
 OneToMany
-- 36
  • 27 (a)
 OneToMany
CSA.3211 36
  • 28 (a)
 OneToMany
CSA.6521 36
  • 29 (a)
 OneToMany
Species with no ortholog for APMAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APMAP Gene

ENSEMBL:
Gene Tree for APMAP (if available)
TreeFam:
Gene Tree for APMAP (if available)

Paralogs for APMAP Gene

No data available for Paralogs for APMAP Gene

Variants for APMAP Gene

Sequence variations from dbSNP and Humsavar for APMAP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_014128 -
rs35097515 - 24,969,529(-) GATAC(A/G)AAGGT reference, missense
rs28364786 - 24,963,944(-) CCTTC(C/T)GG reference, missense, utr-variant-3-prime
rs5839 -- 24,963,531(-) AGTAC(A/G)GTCAT utr-variant-3-prime
rs6707 -- 24,963,530(-) GTACA(A/G)TCATT utr-variant-3-prime

Variation tolerance for APMAP Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for APMAP Gene

Disorders for APMAP Gene

Relevant External Links for APMAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APMAP

No disorders were found for APMAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APMAP Gene

Publications for APMAP Gene

  1. Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3). (PMID: 10945474) Morita M. … Nishimura S. (Genomics 2000) 2 3 4 23 67
  2. Identification of a novel integral plasma membrane protein induced during adipocyte differentiation. (PMID: 11583587) Albrektsen T. … Fleckner J. (Biochem. J. 2001) 2 3 23
  3. Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARI^. (PMID: 20552250) Bogner-Strauss J.G. … Trajanoski Z. (Cell. Mol. Life Sci. 2010) 2 3
  4. Identification of a Novel Function of Adipocyte Plasma Membrane-Associated Protein (APMAP) in Gestational Diabetes Mellitus by Proteomic Analysis of Omental Adipose Tissue. (PMID: 26767403) Ma Y. … Peng Y. (J. Proteome Res. 2016) 3
  5. The adipocyte differentiation protein APMAP is an endogenous suppressor of AI^ production in the brain. (PMID: 25180020) Mosser S. … Fraering P.C. (Hum. Mol. Genet. 2015) 3

Products for APMAP Gene

  • Addgene plasmids for APMAP

Sources for APMAP Gene

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