APMAP Gene
protein-coding GIFtS: 44
GCID: GC20M024945
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adipocyte plasma membrane associated protein(Previous name: chromosome 20 open reading frame 3 )
(Previous symbol: C20orf3)
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Aliases
for APMAP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adipocyte Plasma Membrane Associated Protein1 2 | | C20orf31 2 3 | | BSCv1 2 | | Protein BSCv2 3 | | Chromosome 20 Open Reading Frame 31 | | Adipocyte Plasma Membrane-Associated Protein2 |
Export aliases for APMAP gene to outside databases |
Summaries
for APMAP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: APMAP_HUMAN, Q9HDC9Function: Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role inadipocyte differentiation
Gene Wiki entry for APMAP (C20orf3)
|
Genomic Views
for APMAP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for APMAP
Other transcription factors
Search SABiosciences Chromatin IP Primers for APMAP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APMAP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.2 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.2APMAP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M024945: view genomic region
(about GC identifiers)
Start:
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24,943,561 bp from pter |
End:
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24,973,615 bp from pter |
Size:
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30,055 bases |
Orientation:
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minus strand |
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Proteins
for APMAP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: APMAP_HUMAN, Q9HDC9 (See
protein sequence)Recommended Name: Adipocyte plasma membrane-associated protein Size: 416 amino acids; 46480 Da
Subcellular location: Membrane; Single-pass type II membrane protein
Sequence caution: Sequence=AAQ89435.1; Type=Erroneous initiation; Sequence=BAB11885.1; Type=Erroneous initiation;Sequence=BAB15253.1; Type=Erroneous initiation; Sequence=BAB15578.1; Type=Erroneous initiation;
Secondary accessions: A8K514 B4DXG1 Q6UVZ8 Q9GZS8 Q9NUB2Alternative splicing: 2 isoforms: Q9HDC9-1 Q9HDC9-2 Explore the universe of human proteins at neXtProt for APMAP: NX_Q9HDC9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HDC9
APMAP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065392.1
ENSEMBL proteins: ENSP00000395874 ENSP00000217456 ENSP00000415373
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
APMAP for ontologies About GeneDecksing
APMAP Antibody Products:
Assay Products for APMAP: |
Protein
Domains /
Families
for APMAP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
APMAP for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HDC9ProtoNet protein and cluster: Q9HDC9 1 Blocks protein family: IPB004141 Strictosidine synthase
UniProtKB/Swiss-Prot: APMAP_HUMAN, Q9HDC9Similarity: Belongs to the strictosidine synthase family |
Function
for APMAP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: APMAP_HUMAN, Q9HDC9Function: Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role inadipocyte differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APMAP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APMAP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for APMAP | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APMAP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APMAP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APMAP |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
APMAP for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for APMAP:
|
Pathways & Interactions
for APMAP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APMAP
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/6 Interacting proteins for APMAP (Q9HDC92, 3 ENSP000002174564) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0009058 | biosynthetic process |
IEA | -- |
APMAP for ontologies About GeneDecksing
|
Drugs & Compounds
for APMAP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for APMAP
Search CenterWatch for drugs/clinical trials and news about APMAP
|
Transcripts
for APMAP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for APMAP gene: NM_020531.2 Unigene Cluster for APMAP: Adipocyte plasma membrane associated protein Hs.472330 [show with all ESTs]Unigene Representative Sequence: NM_0205313 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000451442 ENST00000217456(uc002wty.3 uc002wtz.3 uc010zsw.2)
ENST00000447138
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APMAP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APMAP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for APMAP | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APMAP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APMAP |
Additional cDNA sequence: AB033767.1 AK025834.1 AK026866.1 AK291129.1 AK301959.1 AY359076.1 BC003501.1 24 DOTS entries: DT.100840007 DT.91770648 DT.451611 DT.101969958 DT.100828840 DT.100828833 DT.120832609 DT.91770647 DT.100729059 DT.120832567 DT.100828843 DT.120832515 DT.99991711 DT.100828842 DT.95192602 DT.95192704 DT.95192713 DT.100828839 DT.120832529 DT.120832605 DT.75191588 DT.91666431 DT.120832525 DT.80100506 24/696 AceView cDNA sequences (see all 696): BE292811 AA552922 AA694445 CB115461 BM995139 CB153788 AA709451 AI828005 CB069809 BE880934 CR599249 BM708489 CR592912 H48114 BM050891 BM973837 BM720130 AW517878 BU625419 AL526820 BU543867 AA199722 BQ231514 BM849834
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for APMAP (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b |
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| SP1: | | | | | - | | | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for APMAP
|
Expression
for APMAP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See APMAP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APMAP
SOURCE GeneReport for Unigene cluster: Hs.472330
UniProtKB/Swiss-Prot: APMAP_HUMAN, Q9HDC9Tissue specificity: Liver, glomerular and tubular structures of the kidney, endothelial cells, arterial wall andpancreatic islets of Langerhans (at protein level). Found ubiquitously in adult as well as in embryonic tissues. Inadult tissue, the highest expression is found in the liver, placenta and heart. Found on the cell surface ofmonocytes. In embryonic tissue, the highest expression levels is found in the liver and the kidney
SABiosciences Custom PCR Arrays for APMAP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APMAP
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat APMAP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APMAP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APMAP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APMAP |
Orthologs
for APMAP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for APMAP gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for APMAP (if available)
TreeFam Gene Tree for APMAP (if available) |
Paralogs
for APMAP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for APMAP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for APMAP (24943561 - 24973615 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APMAP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APMAP |
|
Disorders
/ Diseases
for APMAP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
APMAP for disorders About GeneDecksing
2  diseases for APMAP: About MalaCardspolycystic ovary syndrome pancreatitis
Export disorders for APMAP gene to outside databases
|
Publications
for APMAP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for APMAP gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with APMAP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3). (PubMed id 10945474)1, 2, 3, 9 Morita M.... Nishimura S. (2000)
- Identification of a novel integral plasma membrane protein induced during adipocyte differentiation. (PubMed id 11583587)1, 3, 9 Albrektsen T....Fleckner J. (2001)
- Reconstruction of gene association network reveals a t ransmembrane protein required for adipogenesis and targeted by PPARg. (PubMed id 20552250)1, 3 Bogner-Strauss J.G....Trajanoski Z. (2010)
- Localization and characterization of the novel protein encoded by C20orf3. (PubMed id 18513186)1, 2 Ilhan A.... Wagner L. (2008)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
|
External Searches for APMAP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing APMAP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing APMAP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing APMAP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for APMAP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for APMAP gene:
Search GeneIP for patents involving APMAP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for APMAP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for APMAP | | OriGene shRNA RFP for APMAP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APMAP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APMAP | | | OriGene Protein Over-expression Lysate for APMAP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for APMAP | | OriGene 3'-UTR Clone for APMAP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APMAP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APMAP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for APMAP | | OriGene Custom Protein Services for APMAP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APMAP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APMAP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APMAP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APMAP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APMAP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APMAP |
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| | | | Search Tocris compounds for APMAP |
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 | | | APMAP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APMAP |
|  |  |  | | | | Search ThermoFisher Antibodies for APMAP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APMAP |
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