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Aliases for APMAP Gene

Aliases for APMAP Gene

  • Adipocyte Plasma Membrane Associated Protein 2 3 5
  • Protein BSCv 3 4
  • C20orf3 3 4
  • Adipocyte Plasma Membrane-Associated Protein 3
  • Chromosome 20 Open Reading Frame 3 2
  • BSCv 3

External Ids for APMAP Gene

Previous HGNC Symbols for APMAP Gene

  • C20orf3

Summaries for APMAP Gene

GeneCards Summary for APMAP Gene

APMAP (Adipocyte Plasma Membrane Associated Protein) is a Protein Coding gene. GO annotations related to this gene include arylesterase activity and strictosidine synthase activity.

UniProtKB/Swiss-Prot for APMAP Gene

  • Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.

Gene Wiki entry for APMAP Gene

Additional gene information for APMAP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APMAP Gene

Genomics for APMAP Gene

Regulatory Elements for APMAP Gene

Enhancers for APMAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H024948 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +40.2 40200 8.4 PKNOX1 ZNF146 NFIB MAX EBF1 CEBPG ZIC2 RAD21 HIC1 GLIS2 CST7 APMAP ACSS1 VN1R108P PYGB PIR45392
GH20H024957 1.2 FANTOM5 ENCODE dbSUPER 11.1 +31.1 31132 9.2 ZFHX2 POLR2A GLIS1 MNT FOS EGR2 FOXA1 CST7 APMAP ACSS1 VN1R108P PIR45392
GH20H024989 1.4 ENCODE dbSUPER 8.4 +1.3 1331 5.2 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3 CST7 ACSS1 APMAP VN1R108P PYGB RNU6-1257P
GH20H024994 1.4 Ensembl ENCODE dbSUPER 8.3 -2.0 -2011 1 PKNOX1 RB1 NFIB ARID4B KLF17 SIN3A RAD21 ZNF143 RCOR1 MIXL1 CST7 ZNF337 NINL APMAP PIR53263
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APMAP on UCSC Golden Path with GeneCards custom track

Promoters for APMAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000135785 479 1801 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3

Genomic Locations for APMAP Gene

Genomic Locations for APMAP Gene
30,055 bases
Minus strand

Genomic View for APMAP Gene

Genes around APMAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APMAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APMAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APMAP Gene

Proteins for APMAP Gene

  • Protein details for APMAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adipocyte plasma membrane-associated protein
    Protein Accession:
    Secondary Accessions:
    • A8K514
    • B4DXG1
    • Q6UVZ8
    • Q9GZS8
    • Q9NUB2

    Protein attributes for APMAP Gene

    416 amino acids
    Molecular mass:
    46480 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89435.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB11885.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15253.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15578.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for APMAP Gene


neXtProt entry for APMAP Gene

Post-translational modifications for APMAP Gene

  • Ubiquitination at posLast=123123, Lys179, and Lys220
  • Glycosylation at posLast=160160 and Asn196
  • Modification sites at PhosphoSitePlus

Other Protein References for APMAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APMAP Gene

Domains & Families for APMAP Gene

Gene Families for APMAP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for APMAP Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the strictosidine synthase family.
  • Belongs to the strictosidine synthase family.
genes like me logo Genes that share domains with APMAP: view

Function for APMAP Gene

Molecular function for APMAP Gene

UniProtKB/Swiss-Prot Function:
Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.

Phenotypes From GWAS Catalog for APMAP Gene

Gene Ontology (GO) - Molecular Function for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004064 arylesterase activity IDA 18513186
GO:0016844 strictosidine synthase activity IEA --
genes like me logo Genes that share ontologies with APMAP: view
genes like me logo Genes that share phenotypes with APMAP: view

miRNA for APMAP Gene

miRTarBase miRNAs that target APMAP

Clone Products

  • Addgene plasmids for APMAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APMAP Gene

Localization for APMAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for APMAP Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APMAP gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
golgi apparatus 3
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0009986 cell surface IDA 18513186
GO:0016020 membrane IDA,IEA 18513186
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with APMAP: view

Pathways & Interactions for APMAP Gene

SuperPathways for APMAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with APMAP: view

No data available for Pathways by source and SIGNOR curated interactions for APMAP Gene

Drugs & Compounds for APMAP Gene

No Compound Related Data Available

Transcripts for APMAP Gene

mRNA/cDNA for APMAP Gene

Unigene Clusters for APMAP Gene

Adipocyte plasma membrane associated protein:
Representative Sequences:

Clone Products

  • Addgene plasmids for APMAP

Alternative Splicing Database (ASD) splice patterns (SP) for APMAP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: -

Relevant External Links for APMAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APMAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APMAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APMAP Gene

This gene is overexpressed in Whole Blood (x7.6) and Liver (x4.9).

Protein differential expression in normal tissues from HIPED for APMAP Gene

This gene is overexpressed in Nasal epithelium (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for APMAP Gene

Protein tissue co-expression partners for APMAP Gene

NURSA nuclear receptor signaling pathways regulating expression of APMAP Gene:


SOURCE GeneReport for Unigene cluster for APMAP Gene:


mRNA Expression by UniProt/SwissProt for APMAP Gene:

Tissue specificity: Liver, glomerular and tubular structures of the kidney, endothelial cells, arterial wall and pancreatic islets of Langerhans (at protein level). Found ubiquitously in adult as well as in embryonic tissues. In adult tissue, the highest expression is found in the liver, placenta and heart. Found on the cell surface of monocytes. In embryonic tissue, the highest expression levels is found in the liver and the kidney.

Evidence on tissue expression from TISSUES for APMAP Gene

  • Nervous system(4.5)
  • Bone marrow(4.4)
  • Liver(4.4)
  • Muscle(4.3)
  • Lung(3.4)
  • Thyroid gland(3.3)
  • Pancreas(3.2)
  • Skin(3.1)
  • Blood(2.8)
  • Eye(2.4)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with APMAP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APMAP Gene

Orthologs for APMAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for APMAP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APMAP 33
  • 99.52 (n)
C20H20ORF3 34
  • 99 (a)
(Canis familiaris)
Mammalia APMAP 33 34
  • 89.08 (n)
(Mus musculus)
Mammalia Apmap 16 34 33
  • 86.59 (n)
(Rattus norvegicus)
Mammalia Apmap 33
  • 86.08 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 85 (a)
-- 34
  • 74 (a)
-- 34
  • 65 (a)
(Bos Taurus)
Mammalia APMAP 33 34
  • 84.39 (n)
(Monodelphis domestica)
Mammalia APMAP 34
  • 82 (a)
(Gallus gallus)
Aves APMAP 34
  • 76 (a)
C3H20ORF3 33
  • 71.81 (n)
(Anolis carolinensis)
Reptilia APMAP 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485177 33
  • 67.47 (n)
Str.3092 33
(Danio rerio)
Actinopterygii apmap 33 34
  • 64.1 (n)
Dr.99 33
fruit fly
(Drosophila melanogaster)
Insecta Hmu 33 34
  • 46.04 (n)
Ssl2 34
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004065 33
  • 45.7 (n)
(Caenorhabditis elegans)
Secernentea CELE_C08E8.2 33
  • 47.18 (n)
C08E8.2 34
  • 35 (a)
F57C2.5 34
  • 34 (a)
T12G3.4 34
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57030 33
  • 47.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
CSA.6521 34
  • 29 (a)
CSA.3211 34
  • 28 (a)
-- 34
  • 27 (a)
Species where no ortholog for APMAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APMAP Gene

Gene Tree for APMAP (if available)
Gene Tree for APMAP (if available)

Paralogs for APMAP Gene

No data available for Paralogs for APMAP Gene

Variants for APMAP Gene

Sequence variations from dbSNP and Humsavar for APMAP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000053456 -- 24,970,756(+) AAGAA(C/T)ATGGA intron-variant
rs1000158229 -- 24,970,914(+) GAATG(C/T)CCCCA intron-variant
rs1000232392 -- 24,966,442(+) TGCCT(C/G)AATCA intron-variant, nc-transcript-variant
rs1000263669 -- 24,966,670(+) AGGAG(C/T)TGAAT intron-variant, nc-transcript-variant
rs1000272313 -- 24,982,763(+) GGCTA(C/G)AATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APMAP Gene

Variant ID Type Subtype PubMed ID
nsv953008 CNV duplication 24416366
nsv953007 CNV deletion 24416366
nsv585745 CNV loss 21841781
nsv522873 CNV gain 19592680
nsv510486 OTHER sequence alteration 20534489
nsv1145859 CNV deletion 26484159
nsv1056345 CNV gain 25217958
esv989269 CNV deletion 20482838
esv3645573 CNV gain 21293372
esv3645567 CNV gain 21293372
esv3645552 CNV gain 21293372
esv2762068 CNV loss 21179565
esv2722323 CNV deletion 23290073
esv2722322 CNV deletion 23290073
esv2722321 CNV deletion 23290073
esv2629879 CNV deletion 19546169
esv2133962 CNV deletion 18987734

Variation tolerance for APMAP Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APMAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APMAP Gene

Disorders for APMAP Gene

Relevant External Links for APMAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for APMAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APMAP Gene

Publications for APMAP Gene

  1. Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3). (PMID: 10945474) Morita M … Nishimura S (Genomics 2000) 2 3 4 22 60
  2. Identification of a novel integral plasma membrane protein induced during adipocyte differentiation. (PMID: 11583587) Albrektsen T … Fleckner J (The Biochemical journal 2001) 2 3 22 60
  3. Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARγ. (PMID: 20552250) Bogner-Strauss JG … Trajanoski Z (Cellular and molecular life sciences : CMLS 2010) 2 3 60
  4. Localization and characterization of the novel protein encoded by C20orf3. (PMID: 18513186) Ilhan A … Wagner L (The Biochemical journal 2008) 3 4 60
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 60

Products for APMAP Gene

  • Addgene plasmids for APMAP

Sources for APMAP Gene

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