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Aliases for APMAP Gene

Aliases for APMAP Gene

  • Adipocyte Plasma Membrane Associated Protein 2 3
  • Protein BSCv 3 4
  • C20orf3 3 4
  • Adipocyte Plasma Membrane-Associated Protein 3
  • Chromosome 20 Open Reading Frame 3 2
  • BSCv 3

External Ids for APMAP Gene

Previous Symbols for APMAP Gene

  • C20orf3

Summaries for APMAP Gene

GeneCards Summary for APMAP Gene

APMAP (Adipocyte Plasma Membrane Associated Protein) is a Protein Coding gene. GO annotations related to this gene include arylesterase activity and strictosidine synthase activity.

UniProtKB/Swiss-Prot for APMAP Gene

  • Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.

Gene Wiki entry for APMAP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APMAP Gene

Genomics for APMAP Gene

Genomic Location for APMAP Gene

Start:
24,962,925 bp from pter
End:
24,992,979 bp from pter
Size:
30,055 bases
Orientation:
Minus strand

Genomic View for APMAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APMAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APMAP Gene

No data available for Regulatory Elements for APMAP Gene

Proteins for APMAP Gene

  • Protein details for APMAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HDC9-APMAP_HUMAN
    Recommended name:
    Adipocyte plasma membrane-associated protein
    Protein Accession:
    Q9HDC9
    Secondary Accessions:
    • A8K514
    • B4DXG1
    • Q6UVZ8
    • Q9GZS8
    • Q9NUB2

    Protein attributes for APMAP Gene

    Size:
    416 amino acids
    Molecular mass:
    46480 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89435.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB11885.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15253.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15578.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for APMAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APMAP Gene

Proteomics data for APMAP Gene at MOPED

Post-translational modifications for APMAP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys123, Lys179, and Lys220
  • Glycosylation at Asn160 and Asn196

Other Protein References for APMAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APMAP Gene

Domains for APMAP Gene

Protein Domains for APMAP Gene

UniProtKB/Swiss-Prot:

APMAP_HUMAN
Family:
  • Belongs to the strictosidine synthase family.:
    • Q9HDC9
genes like me logo Genes that share domains with APMAP: view

No data available for Gene Families for APMAP Gene

Function for APMAP Gene

Molecular function for APMAP Gene

UniProtKB/Swiss-Prot Function: Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.

Gene Ontology (GO) - Molecular Function for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004064 arylesterase activity IDA 18513186
GO:0016844 strictosidine synthase activity IEA --
genes like me logo Genes that share ontologies with APMAP: view

Phenotypes for APMAP Gene

GenomeRNAi human phenotypes for APMAP:
genes like me logo Genes that share phenotypes with APMAP: view

miRNA for APMAP Gene

miRTarBase miRNAs that target APMAP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for APMAP Gene

Localization for APMAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for APMAP Gene

Membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 18513186
GO:0016020 membrane IDA 18513186
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with APMAP: view

Pathways for APMAP Gene

SuperPathways for APMAP Gene

No Data Available

Interacting Proteins for APMAP Gene

Gene Ontology (GO) - Biological Process for APMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with APMAP: view

No data available for Pathways by source for APMAP Gene

Transcripts for APMAP Gene

mRNA/cDNA for APMAP Gene

Unigene Clusters for APMAP Gene

Adipocyte plasma membrane associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APMAP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for APMAP Gene

GeneLoc Exon Structure for
APMAP
ECgene alternative splicing isoforms for
APMAP

Expression for APMAP Gene

mRNA expression in normal human tissues for APMAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APMAP Gene

This gene is overexpressed in Whole Blood (7.6) and Liver (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APMAP Gene

SOURCE GeneReport for Unigene cluster for APMAP Gene Hs.472330

mRNA Expression by UniProt/SwissProt for APMAP Gene

Q9HDC9-APMAP_HUMAN
Tissue specificity: Liver, glomerular and tubular structures of the kidney, endothelial cells, arterial wall and pancreatic islets of Langerhans (at protein level). Found ubiquitously in adult as well as in embryonic tissues. In adult tissue, the highest expression is found in the liver, placenta and heart. Found on the cell surface of monocytes. In embryonic tissue, the highest expression levels is found in the liver and the kidney.
genes like me logo Genes that share expressions with APMAP: view

Orthologs for APMAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for APMAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APMAP 36
  • 99.52 (n)
  • 99.28 (a)
C20H20ORF3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APMAP 36
  • 84.39 (n)
  • 86.65 (a)
APMAP 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APMAP 36
  • 89.08 (n)
  • 91.08 (a)
APMAP 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apmap 36
  • 86.59 (n)
  • 89.64 (a)
Apmap 16
Apmap 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APMAP 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 85 (a)
OneToMany
-- 37
  • 65 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Apmap 36
  • 86.08 (n)
  • 88.83 (a)
chicken
(Gallus gallus)
Aves APMAP 37
  • 76 (a)
OneToOne
C3H20ORF3 36
  • 71.81 (n)
  • 75.66 (a)
lizard
(Anolis carolinensis)
Reptilia APMAP 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485177 36
  • 67.47 (n)
  • 69.4 (a)
Str.3092 36
zebrafish
(Danio rerio)
Actinopterygii apmap 36
  • 64.1 (n)
  • 64.82 (a)
apmap 37
  • 65 (a)
OneToOne
Dr.99 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004065 36
  • 45.7 (n)
  • 38.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hmu 36
  • 46.04 (n)
  • 37.8 (a)
Hmu 37
  • 22 (a)
OneToMany
Ssl2 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C08E8.2 37
  • 35 (a)
OneToMany
CELE_C08E8.2 36
  • 47.18 (n)
  • 38.02 (a)
F57C2.5 37
  • 34 (a)
OneToMany
T12G3.4 37
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57030 36
  • 47.54 (n)
  • 40.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
-- 37
  • 27 (a)
OneToMany
CSA.3211 37
  • 28 (a)
OneToMany
CSA.6521 37
  • 29 (a)
OneToMany
Species with no ortholog for APMAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APMAP Gene

ENSEMBL:
Gene Tree for APMAP (if available)
TreeFam:
Gene Tree for APMAP (if available)

Paralogs for APMAP Gene

No data available for Paralogs for APMAP Gene

Variants for APMAP Gene

Sequence variations from dbSNP and Humsavar for APMAP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs5839 -- 24,963,531(-) AGTAC(A/G)GTCAT utr-variant-3-prime
rs6707 -- 24,963,530(-) GTACA(A/G)TCATT utr-variant-3-prime
rs12242 -- 24,983,922(+) ATCTA(C/T)AGGAG reference, missense
rs727964 -- 24,984,086(+) GGTCC(A/G)AAAGC intron-variant
rs761368 -- 24,964,297(+) TGGCC(C/T)GGCTG intron-variant

Relevant External Links for APMAP Gene

HapMap Linkage Disequilibrium report
APMAP

No data available for Structural Variations from Database of Genomic Variants (DGV) for APMAP Gene

Disorders for APMAP Gene

No disorders were found for APMAP Gene.

No data available for UniProtKB/Swiss-Prot for APMAP Gene

Publications for APMAP Gene

  1. Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3). (PMID: 10945474) Morita M. … Nishimura S. (Genomics 2000) 2 3 4 23
  2. Identification of a novel integral plasma membrane protein induced during adipocyte differentiation. (PMID: 11583587) Albrektsen T. … Fleckner J. (Biochem. J. 2001) 2 3 23
  3. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H. … Aebersold R. (Nat. Biotechnol. 2003) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for APMAP Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate APMAP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for APMAP
    • Block miRNA regulation of APMAP using miScript Target Protectors

    Sources for APMAP Gene

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