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Aliases for APLP2 Gene

Aliases for APLP2 Gene

  • Amyloid Beta (A4) Precursor-Like Protein 2 2 3
  • CDEI Box-Binding Protein 3 4
  • APLP-2 3 4
  • APPL2 3 4
  • CDEBP 3 4
  • APPH 3 4
  • Amyloid Precursor Protein Homolog HSD-2 3
  • Amyloid Protein Homolog 4
  • Amyloid-Like Protein 2 3

External Ids for APLP2 Gene

Previous HGNC Symbols for APLP2 Gene

  • APPL2

Previous GeneCards Identifiers for APLP2 Gene

  • GC11P131940
  • GC11P131452
  • GC11P129973
  • GC11P129477
  • GC11P129445
  • GC11P129939
  • GC11P125891

Summaries for APLP2 Gene

Entrez Gene Summary for APLP2 Gene

  • This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for APLP2 Gene

APLP2 (Amyloid Beta (A4) Precursor-Like Protein 2) is a Protein Coding gene. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include identical protein binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is APLP1.

UniProtKB/Swiss-Prot for APLP2 Gene

  • May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5-GTCACATG-3(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).

Gene Wiki entry for APLP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APLP2 Gene

Genomics for APLP2 Gene

Regulatory Elements for APLP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APLP2 Gene

Start:
130,069,821 bp from pter
End:
130,144,811 bp from pter
Size:
74,991 bases
Orientation:
Plus strand

Genomic View for APLP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APLP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APLP2 Gene

Proteins for APLP2 Gene

  • Protein details for APLP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06481-APLP2_HUMAN
    Recommended name:
    Amyloid-like protein 2
    Protein Accession:
    Q06481
    Secondary Accessions:
    • B3KXX9
    • H7BXI4
    • Q13861
    • Q14594
    • Q14662
    • Q71U10
    • Q7M4L3
    • Q9BT36

    Protein attributes for APLP2 Gene

    Size:
    763 amino acids
    Molecular mass:
    86956 Da
    Quaternary structure:
    • Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity).
    SequenceCaution:
    • Sequence=BAG54641.1; Type=Frameshift; Positions=81; Evidence={ECO:0000305};

    Alternative splice isoforms for APLP2 Gene

neXtProt entry for APLP2 Gene

Proteomics data for APLP2 Gene at MOPED

Post-translational modifications for APLP2 Gene

  • The BPTI/Kunitz inhibitor domain is O-glycosylated.
  • Ubiquitination at Lys744 and Lys756
  • Glycosylation at Thr367, Thr371, Thr380, Ser381, Asn541, and Thr658
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for APLP2 Gene

Domains for APLP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q06481

UniProtKB/Swiss-Prot:

APLP2_HUMAN :
  • Q06481
Domain:
  • Contains 1 BPTI/Kunitz inhibitor domain.
Family:
  • Belongs to the APP family.
genes like me logo Genes that share domains with APLP2: view

No data available for Gene Families for APLP2 Gene

Function for APLP2 Gene

Molecular function for APLP2 Gene

GENATLAS Biochemistry: amyloid beta (A4) precursor protein-like 2
UniProtKB/Swiss-Prot Function: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5-GTCACATG-3(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).

Gene Ontology (GO) - Molecular Function for APLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 7702756
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 16193067
GO:0008201 heparin binding IEA --
GO:0042802 identical protein binding IPI 16193067
genes like me logo Genes that share ontologies with APLP2: view
genes like me logo Genes that share phenotypes with APLP2: view

Animal Models for APLP2 Gene

MGI Knock Outs for APLP2:

Animal Model Products

CRISPR Products

miRNA for APLP2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APLP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for APLP2 Gene

Localization for APLP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APLP2 Gene

Cell membrane; Single-pass type I membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APLP2 Gene COMPARTMENTS Subcellular localization image for APLP2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
endoplasmic reticulum 2
peroxisome 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for APLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 7702756
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane NAS 8485127
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with APLP2: view

Pathways for APLP2 Gene

SuperPathways for APLP2 Gene

Superpath Contained pathways
1 EGFR1 Signaling Pathway
genes like me logo Genes that share pathways with APLP2: view

Pathways by source for APLP2 Gene

1 BioSystems pathway for APLP2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for APLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001967 suckling behavior IEA --
GO:0006878 cellular copper ion homeostasis IEA --
GO:0007176 regulation of epidermal growth factor-activated receptor activity IEA --
GO:0007186 G-protein coupled receptor signaling pathway NAS 8220435
GO:0007617 mating behavior IEA --
genes like me logo Genes that share ontologies with APLP2: view

Compounds for APLP2 Gene

(8) Novoseek inferred chemical compound relationships for APLP2 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 36.6 7
chondroitin sulfate 24 2
zinc 15.2 2
tyrosine 7.23 2
copper 2.51 2
genes like me logo Genes that share compounds with APLP2: view

Transcripts for APLP2 Gene

Unigene Clusters for APLP2 Gene

Amyloid beta (A4) precursor-like protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APLP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for APLP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APLP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for APLP2 Gene

GeneLoc Exon Structure for
APLP2
ECgene alternative splicing isoforms for
APLP2

Expression for APLP2 Gene

mRNA expression in normal human tissues for APLP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APLP2 Gene

SOURCE GeneReport for Unigene cluster for APLP2 Gene Hs.370247

mRNA Expression by UniProt/SwissProt for APLP2 Gene

Q06481-APLP2_HUMAN
Tissue specificity: Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues
genes like me logo Genes that share expressions with APLP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for APLP2 Gene

Orthologs for APLP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for APLP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APLP2 35
  • 99.46 (n)
  • 99.18 (a)
APLP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APLP2 35
  • 86.31 (n)
  • 90.14 (a)
APLP2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APLP2 35
  • 90.6 (n)
  • 94.81 (a)
APLP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aplp2 35
  • 89.39 (n)
  • 92.98 (a)
Aplp2 16
Aplp2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APLP2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APLP2 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aplp2 35
  • 88.86 (n)
  • 93.21 (a)
chicken
(Gallus gallus)
Aves APLP2 35
  • 80.48 (n)
  • 83.56 (a)
APLP2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APLP2 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3393 35
zebrafish
(Danio rerio)
Actinopterygii aplp2 35
  • 75.7 (n)
  • 79.96 (a)
aplp2 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Appl 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apl-1 36
  • 25 (a)
OneToMany
apl-1 37
  • 35 (a)
Species with no ortholog for APLP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APLP2 Gene

ENSEMBL:
Gene Tree for APLP2 (if available)
TreeFam:
Gene Tree for APLP2 (if available)

Paralogs for APLP2 Gene

Paralogs for APLP2 Gene

genes like me logo Genes that share paralogs with APLP2: view

Variants for APLP2 Gene

Sequence variations from dbSNP and Humsavar for APLP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10381 -- 130,144,146(+) TGTCC(A/G)CTGCT utr-variant-3-prime, nc-transcript-variant
rs13207 -- 130,144,040(+) TCCAC(G/T)GCTGG utr-variant-3-prime, nc-transcript-variant
rs13562 -- 130,144,195(+) CTGTA(G/T)CTTAT utr-variant-3-prime, nc-transcript-variant
rs14436 -- 130,144,592(+) TCTTT(C/T)TTTTT utr-variant-3-prime, nc-transcript-variant
rs14437 -- 130,144,613(+) TGAAG(A/G)TTCTG utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for APLP2 Gene

Variant ID Type Subtype PubMed ID
dgv251n67 CNV Gain 20364138
esv27072 CNV Loss 19812545
esv1620466 CNV Deletion 17803354
nsv832295 CNV Gain 17160897
essv12346 CNV CNV 17122850
dgv446e1 CNV Complex 17122850
nsv549 CNV Insertion 18451855

Relevant External Links for APLP2 Gene

HapMap Linkage Disequilibrium report
APLP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APLP2 Gene

Disorders for APLP2 Gene

(1) University of Copenhagen DISEASES for APLP2 Gene

(5) Novoseek inferred disease relationships for APLP2 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 73.5 20
senile plaques 63.5 4
brain diseases 41.3 2
amyloidosis 33.3 1
neurological disorders 0 1

Relevant External Links for APLP2

Genetic Association Database (GAD)
APLP2
Human Genome Epidemiology (HuGE) Navigator
APLP2
genes like me logo Genes that share disorders with APLP2: view

No data available for UniProtKB/Swiss-Prot for APLP2 Gene

Publications for APLP2 Gene

  1. A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein. (PMID: 7702756) von der Kammer H. … Scheit K.H. (DNA Cell Biol. 1994) 3 4 23
  2. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. (PMID: 8220435) Wasco W. … Tanzi R.E. (Nat. Genet. 1993) 3 4 23
  3. Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization. (PMID: 10702673) Leach R. … Krawetz S.A. (Cytogenet. Cell Genet. 1999) 2 3 23
  4. Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. (PMID: 8855266) Guenette S.Y. … Tanzi R.E. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 23
  5. cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta- amyloid precursor protein and its homologues with the mouse Fe65 protein. (PMID: 8894693) Bressler S.L. … Martin G.M. (Hum. Mol. Genet. 1996) 3 23

Products for APLP2 Gene

Sources for APLP2 Gene

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