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Aliases for APLP2 Gene

Aliases for APLP2 Gene

  • Amyloid Beta Precursor Like Protein 2 2 3
  • Amyloid Beta (A4) Precursor-Like Protein 2 2 3 5
  • CDEI Box-Binding Protein 3 4
  • APLP-2 3 4
  • APPL2 3 4
  • CDEBP 3 4
  • APPH 3 4
  • Amyloid Precursor Protein Homolog HSD-2 3
  • Testicular Tissue Protein Li 23 3
  • Amyloid Protein Homolog 4

External Ids for APLP2 Gene

Previous HGNC Symbols for APLP2 Gene

  • APPL2

Previous GeneCards Identifiers for APLP2 Gene

  • GC11P131940
  • GC11P131452
  • GC11P129973
  • GC11P129477
  • GC11P129445
  • GC11P129939
  • GC11P125891

Summaries for APLP2 Gene

Entrez Gene Summary for APLP2 Gene

  • This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for APLP2 Gene

APLP2 (Amyloid Beta Precursor Like Protein 2) is a Protein Coding gene. Diseases associated with APLP2 include alzheimer disease. Among its related pathways are Platelet activation, signaling and aggregation and EGFR1 Signaling Pathway. GO annotations related to this gene include identical protein binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is APLP1.

UniProtKB/Swiss-Prot for APLP2 Gene

  • May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5-GTCACATG-3(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).

Gene Wiki entry for APLP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APLP2 Gene

Genomics for APLP2 Gene

Regulatory Elements for APLP2 Gene

Promoters for APLP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APLP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for APLP2 Gene

Chromosome:
11
Start:
130,069,821 bp from pter
End:
130,144,811 bp from pter
Size:
74,991 bases
Orientation:
Plus strand

Genomic View for APLP2 Gene

Genes around APLP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APLP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APLP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APLP2 Gene

Proteins for APLP2 Gene

  • Protein details for APLP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06481-APLP2_HUMAN
    Recommended name:
    Amyloid-like protein 2
    Protein Accession:
    Q06481
    Secondary Accessions:
    • B3KXX9
    • H7BXI4
    • Q13861
    • Q14594
    • Q14662
    • Q71U10
    • Q7M4L3
    • Q9BT36

    Protein attributes for APLP2 Gene

    Size:
    763 amino acids
    Molecular mass:
    86956 Da
    Quaternary structure:
    • Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity).
    SequenceCaution:
    • Sequence=BAG54641.1; Type=Frameshift; Positions=81; Evidence={ECO:0000305};

    Alternative splice isoforms for APLP2 Gene

neXtProt entry for APLP2 Gene

Proteomics data for APLP2 Gene at MOPED

Post-translational modifications for APLP2 Gene

  • The BPTI/Kunitz inhibitor domain is O-glycosylated.
  • Ubiquitination at Lys 744 and Lys 756
  • Glycosylation at Thr 367, Thr 380, Ser 381, Asn 541, and Thr 658
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for APLP2 Gene

Domains & Families for APLP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q06481

UniProtKB/Swiss-Prot:

APLP2_HUMAN :
  • Contains 1 BPTI/Kunitz inhibitor domain.
  • Belongs to the APP family.
Domain:
  • Contains 1 BPTI/Kunitz inhibitor domain.
Family:
  • Belongs to the APP family.
genes like me logo Genes that share domains with APLP2: view

No data available for Gene Families for APLP2 Gene

Function for APLP2 Gene

Molecular function for APLP2 Gene

GENATLAS Biochemistry:
amyloid beta (A4) precursor protein-like 2
UniProtKB/Swiss-Prot Function:
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5-GTCACATG-3(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).

Gene Ontology (GO) - Molecular Function for APLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 16193067
genes like me logo Genes that share ontologies with APLP2: view
genes like me logo Genes that share phenotypes with APLP2: view

Animal Models for APLP2 Gene

MGI Knock Outs for APLP2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APLP2 Gene

Localization for APLP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APLP2 Gene

Cell membrane; Single-pass type I membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APLP2 Gene COMPARTMENTS Subcellular localization image for APLP2 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 2
peroxisome 2
cytosol 1
endosome 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for APLP2 Gene

Pathways & Interactions for APLP2 Gene

genes like me logo Genes that share pathways with APLP2: view

Pathways by source for APLP2 Gene

SIGNOR curated interactions for APLP2 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for APLP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with APLP2: view

Drugs & Compounds for APLP2 Gene

(5) Drugs for APLP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for APLP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APLP2: view

Transcripts for APLP2 Gene

Unigene Clusters for APLP2 Gene

Amyloid beta (A4) precursor-like protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APLP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for APLP2 Gene

GeneLoc Exon Structure for
APLP2
ECgene alternative splicing isoforms for
APLP2

Expression for APLP2 Gene

mRNA expression in normal human tissues for APLP2 Gene

Protein differential expression in normal tissues from HIPED for APLP2 Gene

This gene is overexpressed in Vitreous humor (20.9), Liver (9.4), Peripheral blood mononuclear cells (8.2), Cerebrospinal fluid (6.7), and Amniocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for APLP2 Gene



SOURCE GeneReport for Unigene cluster for APLP2 Gene Hs.370247

mRNA Expression by UniProt/SwissProt for APLP2 Gene

Q06481-APLP2_HUMAN
Tissue specificity: Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
genes like me logo Genes that share expression patterns with APLP2: view

Protein tissue co-expression partners for APLP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for APLP2 Gene

Orthologs for APLP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for APLP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APLP2 36
  • 99 (a)
OneToOne
APLP2 35
  • 99.46 (n)
  • 99.18 (a)
cow
(Bos Taurus)
Mammalia APLP2 36
  • 90 (a)
OneToOne
APLP2 35
  • 86.31 (n)
  • 90.14 (a)
dog
(Canis familiaris)
Mammalia APLP2 35
  • 90.6 (n)
  • 94.81 (a)
APLP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aplp2 16
Aplp2 35
  • 89.39 (n)
  • 92.98 (a)
Aplp2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APLP2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APLP2 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aplp2 35
  • 88.86 (n)
  • 93.21 (a)
chicken
(Gallus gallus)
Aves APLP2 35
  • 80.48 (n)
  • 83.56 (a)
APLP2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APLP2 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3393 35
zebrafish
(Danio rerio)
Actinopterygii aplp2 36
  • 66 (a)
OneToOne
aplp2 35
  • 75.7 (n)
  • 79.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Appl 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apl-1 37
  • 35 (a)
apl-1 36
  • 25 (a)
OneToMany
Species with no ortholog for APLP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APLP2 Gene

ENSEMBL:
Gene Tree for APLP2 (if available)
TreeFam:
Gene Tree for APLP2 (if available)

Paralogs for APLP2 Gene

Paralogs for APLP2 Gene

genes like me logo Genes that share paralogs with APLP2: view

Variants for APLP2 Gene

Sequence variations from dbSNP and Humsavar for APLP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10381 -- 130,144,146(+) TGTCC(A/G)CTGCT nc-transcript-variant, utr-variant-3-prime
rs13207 -- 130,144,040(+) TCCAC(G/T)GCTGG nc-transcript-variant, utr-variant-3-prime
rs651935 -- 130,129,005(-) CACCC(A/G)GAGGA intron-variant
rs674442 -- 130,133,075(-) GCTCC(A/C)AATTA intron-variant
rs694875 -- 130,132,648(-) CTGAA(A/C/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APLP2 Gene

Variant ID Type Subtype PubMed ID
dgv251n67 CNV Gain 20364138
esv27072 CNV Loss 19812545
esv1620466 CNV Deletion 17803354
nsv832295 CNV Gain 17160897
essv12346 CNV CNV 17122850
dgv446e1 CNV Complex 17122850
nsv549 CNV Insertion 18451855

Variation tolerance for APLP2 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.19; 80.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APLP2 Gene

HapMap Linkage Disequilibrium report
APLP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APLP2 Gene

Disorders for APLP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for APLP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search APLP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for APLP2

Genetic Association Database (GAD)
APLP2
Human Genome Epidemiology (HuGE) Navigator
APLP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APLP2
genes like me logo Genes that share disorders with APLP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APLP2 Gene

Publications for APLP2 Gene

  1. A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein. (PMID: 7702756) von der Kammer H. … Scheit K.H. (DNA Cell Biol. 1994) 3 4 23 67
  2. Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization. (PMID: 10702673) Leach R. … Krawetz S.A. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. (PMID: 19126676) Kaden D. … Multhaup G. (J. Cell. Sci. 2009) 3 23
  4. Amyloid precursor-like protein 2 association with HLA class I molecules. (PMID: 19184004) Tuli A. … Solheim J.C. (Cancer Immunol. Immunother. 2009) 3 23
  5. Specificity of amyloid precursor-like protein 2 interactions with MHC class I molecules. (PMID: 18452037) Tuli A. … Solheim J.C. (Immunogenetics 2008) 3 23

Products for APLP2 Gene

Sources for APLP2 Gene

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