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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APLP2 Gene

protein-coding GIFtS: 60
GCID: GC11P129939

amyloid beta (A4) precursor-like protein 2

(Previous symbol: APPL2)

Explore 16 diseases affiliated with
APLP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Amyloid Beta (A4) Precursor-Like Protein 2¹ ²		CDEI Box-Binding Protein² ³
APPH¹ ² ³		Amyloid Precursor Protein Homolog HSD-2²
APPL2¹ ² ³		Amyloid-Like Protein 2²
APLP-2² ³		Amyloid Protein Homolog³
CDEBP² ³

External Ids:	HGNC: 598¹	Entrez Gene: 334²	Ensembl: ENSG00000084234⁷	OMIM: 104776⁵	UniProtKB: Q06481³

ORGUL members:
	NONCODE:n407015

Export aliases for APLP2 gene to outside databases

Previous GC identifers: GC11P131940 GC11P131452 GC11P129973 GC11P129477 GC11P129445 GC11P125891

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APLP2:

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein)

family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc-

binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and

intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I

molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning

and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple

alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq, Aug

2011)

UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481

Function: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards

coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI

box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn

nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)

Gene Wiki entry for APLP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APLP2 gene promoter:
TBP p53 NF-YA NF-YB FOXC1 CBF-A CBF-B CP1A Pax-4a NF-Y
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APLP2 promoter sequence

Search SABiosciences Chromatin IP Primers for APLP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APLP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q24

APLP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APLP2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P129939: view genomic region (about GC identifiers)

Start:	129,939,716 bp from pter	End:	130,014,706 bp from pter
Size:	74,991 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481 (See protein sequence)

Recommended Name: Amyloid-like protein 2 precursor

Size: 763 amino acids; 86956 Da

Subunit: Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by

tyrosine phosphorylation of the NPXY motif (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential). Nucleus (Potential)

Secondary accessions: Q13861 Q14594 Q14662 Q71U10 Q7M4L3 Q9BT36

Alternative splicing: 5 isoforms: Q06481-1 Q06481-2 Q06481-3 Q06481-4 Q06481-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APLP2: NX_Q06481

Post-translational modifications:

The BPTI/Kunitz inhibitor domain is O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q06481

APLP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001135748.1 NP_001135749.1 NP_001135750.1 NP_001230228.1 NP_001633.1

ENSEMBL proteins:

ENSP00000434592 ENSP00000431893 ENSP00000433582 ENSP00000434059 ENSP00000434379

ENSP00000435470 ENSP00000435914 ENSP00000263574 ENSP00000263575 ENSP00000345444

ENSP00000278756 ENSP00000444122 ENSP00000443728

Human Recombinant Protein Products:

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	Novus Biologicals APLP2 Proteins Novus Biologicals APLP2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for APLP2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	7702756
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	NAS	8485127

APLP2 for ontologies About GeneDecksing

APLP2 Antibody Products:

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Assay Products for APLP2:

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	Uscn ELISAs and CLIAs for APLP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

APLP2 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR024329 Amyloid_glyco_E2_domain

IPR019745 Amyloid_glyco_intracell_CS

IPR002223 Prot_inh_Kunz-m

IPR008155 Amyloid_glyco

IPR008154 Amyloid_glyco_extra

Graphical View of Domain Structure for InterPro Entry Q06481

ProtoNet protein and cluster: Q06481

2 Blocks protein families:

IPB002223 Pancreatic trypsin inhibitor (Kunitz)

IPB008155 Amyloidogenic glycoprotein (Amyloid A4)

UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481

Similarity: Belongs to the APP family

Similarity: Contains 1 BPTI/Kunitz inhibitor domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481

Function: May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards

coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI

box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn

nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity)

Genatlas biochemistry entry for APLP2:

amyloid beta (A4) precursor protein-like 2

miRNA Products:		OriGene 3'-UTR Clone (see all 4): APLP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APLP2
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate APLP2 (see all 35):
		hsa-miR-429 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-548l hsa-miR-409-5p hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: APLP2 3' UTR sequence

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for APLP2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLP2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	7702756
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0008201	heparin binding	IEA	--
GO:0042802	identical protein binding	IPI	16193067

APLP2 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for APLP2:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Increased TP53 protein express

Animal Models:
Mouse knock-outs for APLP2: Aplp2^tm1Min Aplp2^tm1Dbo
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Aplp2):

behavior/neurological	embryogenesis	growth/size	integument	mortality/aging
nervous system	normal	reproductive system

APLP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for APLP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for APLP2 (Q06481^{1, 2, 3} ENSP00000263574⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUN	P05412¹^,³, ENSP00000360266⁴	EBI-79306,EBI-852823 I2D: score=3 STRING: ENSP00000360266
APLP1	P51693¹^,³, ENSP00000221891⁴	EBI-79306,EBI-74648 I2D: score=2 STRING: ENSP00000221891
ZNF512B	Q96KM6²^,³	MINT-60793 I2D: score=2
DEDD	O75618¹^,³	EBI-79306,EBI-1043164 I2D: score=1
ETS1	P14921¹^,³	EBI-79306,EBI-913209 I2D: score=1

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001967	suckling behavior	IEA	--
GO:0006878	cellular copper ion homeostasis	IEA	--
GO:0007176	regulation of epidermal growth factor-activated receptor activity	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	NAS	8220435
GO:0007617	mating behavior	IEA	--

APLP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

APLP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for APLP2
8 Novoseek chemical compound relationships for APLP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	36.6	8	16150056 (3), 9121703 (2), 17908044 (1), 14597230 (1)
chondroitin sulfate	24	4	7616233 (1), 8863657 (1)
zinc	15.2	3	7929392 (2)
tyrosine	7.23	2	18577100 (1), 11784781 (1)
copper	2.51	3	15465814 (2)
glutamate	0	1	10624803 (1)
heparin	0	2	7819340 (1), 8588942 (1)
nmda	0	1	10624803 (1)

Search CenterWatch for drugs/clinical trials and news about APLP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APLP2 gene (5 alternative transcripts):

NM_001142276.1 NM_001142277.1 NM_001142278.1 NM_001243299.1 NM_001642.2

Unigene Cluster for APLP2:

Amyloid beta (A4) precursor-like protein 2

Hs.370247 [show with all ESTs]

Unigene Representative Sequence: NM_001642

18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):

ENST00000532456 ENST00000533616 ENST00000530107 ENST00000534761 ENST00000530416

ENST00000533532 ENST00000530132 ENST00000533195 ENST00000533618 ENST00000524449

ENST00000533713 ENST00000529235 ENST00000534582 ENST00000527702 ENST00000534001

ENST00000526330 ENST00000529701 ENST00000528499

miRNA Products:		OriGene 3'-UTR Clone (see all 4): APLP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APLP2
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate APLP2 (see all 35):
		hsa-miR-429 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-548l hsa-miR-409-5p hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: APLP2 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APLP2

Additional cDNA sequence:

AF086183.1 AF168956.1 AK056883.1 AK128162.1 AK225283.1 AK296765.1 AK300378.1 AK304736.1

AK308248.1 AK308932.1 BC000373.2 BC004371.1 L09209.1 L19597.1 L23113.1 L23114.1

L27631.1 NR_024515.1 NR_024516.1 S60099.1 Z22572.1

24/76 DOTS entries (see all 76):

DT.100892323 DT.95306989 DT.451432 DT.40114693 DT.100892329 DT.95307013 DT.95306982 DT.85101610

DT.120726827 DT.100892291 DT.120726695 DT.100892277 DT.120726848 DT.95306907 DT.91772974 DT.95219600

DT.86995872 DT.92028755 DT.100892292 DT.99964200 DT.100892333 DT.97863919 DT.101985416 DT.95351011

24/2055 AceView cDNA sequences (see all 2055):

BU186223 BM835793 N31553 BE081114 AI216635 H84593 BP351867 BG939284

BF594225 BM802360 CA773521 BF726542 AI568588 R70091 BM785687 AI497802

CB068612 AA322486 AU134093 AW188006 AA366376 AI814609 AA479414 CA843015

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for APLP2 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	·	15e
SP1:							-				-																-				-				-
SP2:																									-		-				-				-
SP3:																															-				-
SP4:
SP5:																																			-

ECgene alternative splicing isoforms for APLP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APLP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCTACCCA

About this image

APLP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See APLP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APLP2

SOURCE GeneReport for Unigene cluster: Hs.370247

UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481

Tissue specificity: Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues

SABiosciences Expression via Pathway-Focused PCR Array including APLP2:

Alzheimer's Disease in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for APLP2 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	APLP2¹	amyloid beta (A4) precursor-like protein 2	78.69(n) 82.27(a)		419727 NM_001006317.2 NP_001006317.2
lizard (Anolis carolinensis)	Reptilia	APLP2⁶	--	81(a)	1 ↔ 1	GL343197.1(56710-79425)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.3393²	Transcribed sequence with weak similarity to protein more	78.4(n)		CF378752.1
zebrafish (Danio rerio)	Actinopterygii	aplp2¹	amyloid beta (A4) precursor-like protein 2	72.39(n) 74.63(a)		796801 NM_001123012.1 NP_001116484.1
fruit fly (Drosophila melanogaster)	Insecta	Appl⁶	beta amyloid protein precursor-like	20(a)	1 → many	X(424503-473077)
worm (Caenorhabditis elegans)	Secernentea	apl-1³	Expression: head neurons, motor neurons, neurons, more	35(a)		X(5148379-5152143) --

ENSEMBL Gene Tree for APLP2 (if available)
TreeFam Gene Tree for APLP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for APLP2 gene

APP² APLP1²

8 SIMAP similar genes for APLP2 using alignment to 11 protein entries: APLP2_HUMAN (see all proteins):

APP APLP1 EPPIN COL28A1 SPINT3 ITIL

TFPI2 TFPI

APLP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7129708^1,2	C,F,A,H,	--	125889549(+)	`TTTCAC/GAGTTC`	6	--	us2k¹ tfbs³		7		NS EA NA WA	652
rs1471199^1,2	C,F,A,H,	--	125890060(+)	`CGAGTG/ACCACA`	6	--	us2k¹		6		EA NA MN NS	324
rs7130579^1,2	C,F,H,	--	125890070(+)	`AGTGGG/CAAACA`	6	--	us2k¹		8		NS EA WA NA	662
rs61913743^1,2		--	125890095(+)	`CAGAAG/ACGATA`	7	--	us2k¹		2		NA	122
rs73023481^1,2	C,	--	125890350(+)	`CCTTTA/CTATTG`	7	--	us2k¹		0	--	--	--	--
rs73583419^1,2	C,	--	125891003(+)	`AGGGGC/AAGGGG`	7	--	us2k¹		4		CSA WA EA	241
rs59295796^1,2		--	125891850(+)	`TCGGGG/TCTGCT`	7	--	int¹ us2k¹		0	--	--	--	--
rs59168429^1,2		--	125891880(+)	`GGCCGA/CCCCAG`	7	--	int¹ us2k¹		0	--	--	--	--
rs74946162^1,2	C,	--	125892015(+)	`CTCCAC/GGGGCG`	7	--	int¹ us2k¹		0	--	--	--	--
rs61216509^1,2		--	125892020(+)	`GGGGCC/GGCCCC`	7	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for APLP2 (129939716 - 130014706 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for APLP2
7 CNVs: 3869 75843 86077 71398 86080 86079 75844
2 Indels: 86076 24658

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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APLP2 for disorders           About GeneDecksing

OMIM gene information: 104776    OMIM disorders: --

16 diseases for APLP2:    About MalaCards

alzheimer's disease spinocerebellar ataxia amyloidosis brain disease

lissencephaly ataxia thrombosis dementia

pharyngitis infertility breast cancer cerebritis

neuroblastoma pancreatitis neuronitis cholesterol

1 disease from the University of Copenhagen DISEASES database for APLP2:

Alzheimer's disease

5 Novoseek disease relationships for APLP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	73.5	24	9037522 (4), 8863657 (3), 9037521 (2), 9389585 (1) (see all 14)
senile plaques	63.5	5	7592716 (1), 8863657 (1), 10624803 (1), 9729270 (1)
brain diseases	41.3	2	8863657 (1), 9037522 (1)
amyloidosis	33.3	1	9923612 (1)
neurological disorders	0	1	9037522 (1)

Human Genome Epidemiology (HuGE) Navigator: APLP2 (1 document)

Export disorders for APLP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for APLP2 gene, integrated from 9 sources (see all 140):
(articles sorted by number of sources associating them with APLP2)

Utopia: connect your pdf to the dynamic
world of online information

A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein. (PubMed id 7702756)^{1, 2, 9} von der Kammer H.... Scheit K.H. (1994)
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. (PubMed id 8220435)^{1, 2, 9} Wasco W.... Tanzi R.E. (1993)
Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization. (PubMed id 10702673)^{1, 3, 9} Leach R....Krawetz S.A. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family. (PubMed id 8485127)^{1, 2} Sprecher C.A.... Foster D.C. (1993)
Specificity of amyloid precursor-like protein 2 interactions with MHC class I molecules. (PubMed id 18452037)^{1, 9} Tuli A....Solheim J.C. (2008)
Amyloid precursor-like protein 2 association with HLA class I molecules. (PubMed id 19184004)^{1, 9} Tuli A....Solheim J.C. (2009)
A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells. (PubMed id 11443060)^{1, 9} Xu K.P....Yu F.S. (2001)
Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system. (PubMed id 9556595)^{1, 9} Lyckman A.W....Moya K.L. (1998)
Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule. (PubMed id 18641335)^{1, 9} Tuli A....Solheim J.C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 334	HGNC: 598	AceView: APLP2	Ensembl:ENSG00000084234	euGenes: HUgn334
ECgene: APLP2	H-InvDB: APLP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for APLP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for APLP2 gene
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Patent Information for APLP2 gene:
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GeneCards and IP:
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amyloid beta (A4) precursor-like protein 2

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amyloid beta (A4) precursor-like protein 2

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