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APLP2 Gene

protein-coding GIFtS: 62

GC11P129445

amyloid beta (A4) precursor-like protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: APPL2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
APPH ^¹, ², ³
APPL2 ^², ³
CDEBP ^², ³

Descriptions
Amyloid protein homolog ^³
CDEI box-binding protein ^³
amyloid beta (A4) precursor-like protein 2 ^²
amyloid beta precursor-like protein 2 ^¹
amyloid precursor protein homolog HSD-2 ^²

External Ids
HGNC: 598¹
Entrez Gene: 334²
UniProtKB: Q06481³
Ensembl: ENSG00000084234⁷

Search outside databases for aliases for APLP2 gene

Previous GC identifers: GC11P131940 GC11P131452 GC11P129973 GC11P129477

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481

Function: May play a role in the regulation of hemostasis. The soluble form may have inhibitory

properties towards coagulation factors. May interact with cellular G-protein signaling pathways.

May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA

and plasma and glandular kallikrein

Gene Wiki entry for APLP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the APLP2 gene

Entrez Gene cytogenetic band: 11q23-q25|11q24 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q24

APLP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P129445: (about GC identifiers)

Start:	129,445,011 bp from pter
End:	129,519,910 bp from pter
Size:	74,900 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481 (See protein sequence)

Recommended Name: Amyloid-like protein 2 precursor

Size: 763 amino acids; 86956 Da

Subunit: Interacts with CPEB1 (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential). Nucleus

(Potential)

Secondary accessions: Q13861 Q14594 Q14662 Q71U10 Q7M4L3 Q9BT36

Alternative splicing: 5 isoforms: Q06481-1 Q06481-2 Q06481-3 Q06481-4 Q06481-5 (Additional isoforms seem to exist)

Post-translational modifications:

The BPTI/Kunitz inhibitor domain is O-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001135748.1 NP_001135749.1 NP_001135750.1 NP_001633.1

ENSEMBL proteins:

ENSP00000263574 ENSP00000278756 ENSP00000345444 ENSP00000263575

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (APLP2)
	Human Recombinant Proteins from Abnova (APLP2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	7702756
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	NAS	8485127

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Antibodies for APLP2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for APLP2
	R&D Systems Antibodies for APLP2 (APLP-2)
	Antibodies from Abcam (APLP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (APLP2)
	Novus Biologicals Antibody for APLP2

Assays for APLP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q06481

ProtoNet protein and cluster: Q06481

2 Blocks protein families:

IPB002223 Pancreatic trypsin inhibitor (Kunitz)

IPB008155 Amyloidogenic glycoprotein (Amyloid A4)

UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481

Similarity: Belongs to the APP family

Similarity: Contains 1 BPTI/Kunitz inhibitor domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (APLP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (APLP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_001642

Applied Biosystems Silencer® siRNAs for APLP2

Sigma-Aldrich siRNA and siRNA Panels for APLP2

Sigma-Aldrich shRNA for APLP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for APLP2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001142276
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001142276
untagged cDNA clones in CMV expression vector (see all 5): BC004371

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001642

UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481

Function: May play a role in the regulation of hemostasis. The soluble form may have inhibitory

properties towards coagulation factors. May interact with cellular G-protein signaling pathways.

May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA

and plasma and glandular kallikrein

Genatlas biochemistry entry for APLP2:

amyloid beta (A4) precursor protein-like 2

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Aplp2):

behavior/neurological	embryogenesis	growth/size	hearing/vestibular/ear	lethality-postnatal
lethality-prenatal/perinatal	normal	reproductive system	skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	7702756
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--
GO:0042802	identical protein binding	IPI	16193067

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for APLP2

5/20 Interacting proteins for APLP2 (Q06481^{1, 2} ENSP00000263574³) via UniProtKB, MINT, and/or STRING (see all 20 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APBB2	Q92870¹, ENSP00000318965³	EBI-79306, EBI-79277 STRING (score=.989)
APLP1	P51693¹, ENSP00000221891³	EBI-79306, EBI-74648 STRING (score=.837)
APLP2	Q06481¹	EBI-79306, EBI-79306
Slc5a7 Slc5a7 (xeno)	Q8BGY9¹	EBI-79306, EBI-2010752
ZNF512B	Q96KM6²	MINT-60793

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor protein signaling pathway	NAS	8220435

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for APLP2
4 Novoseek chemical compound relationships for APLP2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
chondroitin sulfate	26.12	4	7616233 (1), 8863657 (1)
zinc	17.80	3	7929392 (2)
copper	5.34	3	15465814 (2)
tyrosine	3.32	2	18577100 (1), 11784781 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (APLP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (APLP2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_001642

Sigma-Aldrich siRNA and siRNA Panels for APLP2

Sigma-Aldrich shRNA for APLP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001142276 NM_001142277 NM_001142278 NM_001642

REFSEQ mRNAs for APLP2 gene (4 alternative transcripts):

NM_001142276.1 NM_001142277.1 NM_001142278.1 NM_001642.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001142276 NM_001142277 NM_001142278 NM_001642

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001142276
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001142276
                                 untagged cDNA clones in CMV expression vector (see all 5): BC004371

Additional cDNA sequence:

AF086183.1 AF168956.1 AK056883.1 AK122834.1 AK124457.1 AK128162.1 AK225283.1 AK296765.1

AK300378.1 AK304736.1 AK308248.1 AK308932.1 BC000373.2 BC004371.1 BX647107.1 CR602481.1

L09209.1 L19597.1 L23113.1 L23114.1 L27631.1 S60099.1 Z22572.1

24/77 DOTS entries (see all 77 ):

DT.100892323 DT.95306989 DT.451432 DT.40114693 DT.100892329 DT.95307013 DT.95306982 DT.85101610

DT.120726827 DT.100892291 DT.120726695 DT.100892277 DT.120726848 DT.95306907 DT.91772974 DT.95219600

DT.86995872 DT.99964200 DT.92028755 DT.100892292 DT.100892333 DT.97863919 DT.101985416 DT.95351011

24/2055 AceView cDNA sequences (see all 2055 ):

BE218694 BM819166 AW881306 AI085801 CA843771 BF847973 L19597 AI597629

BM832783 AI097140 H84593 BM667881 BQ267446 AA975058 BM786026 BQ127969

AI298842 BQ021043 BP356517 CB107722 AA862998 W60398 AI268602 AA721978

highest scoring ESTs for APLP2:

S60099 AA009750 AA010590 AA013198 AA022510 AA022629 AA022777 AA023027 AA025468 AA025664

Unigene Cluster for APLP2:

Amyloid beta (A4) precursor-like protein 2

Hs.709184 [show with all ESTs]

Unigene Representative Sequence: BX647107

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for APLP2 (see all 7 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	·	15e
SP1:							-				-																-				-				-
SP2:																									-		-				-				-
SP3:																															-				-
SP4:
SP5:																																			-

About this scheme

ECgene alternative splicing isoforms for APLP2

4 Ensembl transcripts including schematic representations:

ENST00000263574 ENST00000278756 ENST00000338167 ENST00000345598

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

APLP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for APLP2

¹ / ² / ³

13 probe-sets matching APLP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33944_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	S60099	1.00	0.90	0.95	1
211404_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC004371	0.80	0.88	0.84	1
208704_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000373	0.80	0.88	0.84	1
208703_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG427393	0.80	1.00	0.91	1
208702_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI525212	0.40	1.00	0.76	1
208248_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_001642	0.60	1.00	0.82	1
214875_x_at²^{, 3}	U133-A	1	0.91	1.00	--	--	AW001847	0.60	1.00	0.82	1
211404_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208704_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208703_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208702_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208248_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
214875_x_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCTCTACCCA

SOURCE GeneReport for Unigene cluster: Hs.709184
Expression variation in blood from EXPOLDB for APLP2
UniProtKB/Swiss-Prot: APLP2_HUMAN, Q06481
Tissue specificity: In placenta, brain, heart, lung, liver, kidney and endothelial tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for APLP2 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	APLP2¹	--	amyloid beta (A4) precursor-like protein 2	90.56(n) 94.5(a)	479393 XM_851401.1 XP_856494.1
chimpanzee (Pan troglodytes)	APLP2¹	--	amyloid beta (A4) precursor-like protein 2	99.56(n) 99.47(a)	741867 XM_001155152.1 XP_001155152.1
cow (Bos taurus)	APLP2¹	--	similar to Amyloid-like protein 2 precursor (Amyloid more	86.46(n) 90.3(a)	785005 XM_001251234.1 XP_001251235.1
rat (Rattus norvegicus)	Aplp2¹	--	amyloid beta (A4) precursor-like protein 2	89.81(n) 94.43(a)	64312 XM_343513.3 XP_343514.3
mouse (Mus musculus)	Aplp2^{1, 5}	9 (13.00 cM)⁵	amyloid beta (A4) precursor-like protein 2^{1, 5}	84.99(n)¹ 86.76(a)¹	11804¹ NM_009691.2¹ NP_033821.1¹ AI790698⁵ AK013376⁵ (see all 50)

About this table Species with no ortholog for APLP2

ENSEMBL Gene Tree for APLP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for APLP2 gene

APP² APLP1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/510 NCBI SNPs in APLP2 are shown (see all 510 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 135)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs7926547^1,2	A,C,F,H	129444132(+)	`CTCTAC/GTGAAG`	1	--	ng5¹		6	EU EA WA MN	768
	rs6590436^1,2	A,C,F,H	129444408(+)	`AGCAGC/GGCGGG`	1	--	ng5¹		1	EU	120
	rs11825992^1,2	A,C,F,H	129520212(+)	`CAGAGG/AAATGC`	1	--	ng3¹		8	EU EA WA	836
	rs12577779^1,2	C,F,H	129520167(+)	`CTTAAT/CGCTAC`	1	--	ng3¹		4	EU EA WA	402
	rs3740882^1,2	C,F,H	129519579(+)	`GCTGTC/TCCTGA`	1	--	ut3¹ ese³		12	EA NA EU WA	2460
	rs3740881^1,2	C,F,H	129515523(+)	`AGCAGG/AATGGG`	1	N/D	mis¹ ese³		13	EA EU WA	2760
	rs7129708^1,2	A,F,H	129443146(+)	`TTTCAC/GAGTTC`	1	--	ng5¹ tfbs³		4	EU EA WA	412
	rs7103775^1,2	A,C,H	129444366(+)	`GCCGGG/ACTCAG`	1	--	ng5¹		4	EU EA WA	418
	rs12575762^1,2	C,F,H	129443071(+)	`GCGGCT/Ggtgtc`	1	--	ng5¹		4	EU EA WA	410
	rs11822318^1,2	C,H	129496816(+)	`CCCTCA/GGACAA`	1	Q/R	mis¹ ese³		4	EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for APLP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 104776

5 Novoseek disease relationships for APLP2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	73.04	24	9037522 (4), 8863657 (3), 9037521 (2), 9389585 (1) (see all 14)
senile plaques	65.23	5	7592716 (1), 8863657 (1), 10624803 (1), 9729270 (1)
brain diseases	43.64	2	8863657 (1), 9037522 (1)
amyloidosis	35.56	1	9923612 (1)
neurological disorders	0.07	1	9037522 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/111 PubMed articles for APLP2 gene (see all 111 ):

A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein. (PubMed id 7702756)^{1, 3, 4} von der Kammer H.... Scheit K.H. (1994)
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. (PubMed id 8220435)^{1, 3, 4} Wasco W.... Tanzi R.E. (1993)
Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization. (PubMed id 10702673)^{1, 2, 3} Leach R....Krawetz S.A. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family. (PubMed id 8485127)^{3, 4} Sprecher C.A.... Foster D.C. (1993)
Specificity of amyloid precursor-like protein 2 interactions with MHC class I molecules. (PubMed id 18452037)^{1, 3} Tuli A....Solheim J.C. (2008)
A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells. (PubMed id 11443060)^{1, 3} Xu K.P....Yu F.S. (2001)
Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system. (PubMed id 9556595)^{1, 3} Lyckman A.W....Moya K.L. (1998)
Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule. (PubMed id 18641335)^{1, 3} Tuli A....Solheim J.C. (2008)
CDEBP, a site-specific DNA-binding protein of the 'APP-like' family, is required during the early development of the mouse. (PubMed id 7539437)^{1, 3} Blangy A....Rassoulzadegan M. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 334	HGNC: 598	AceView: APLP2	Ensembl:ENSG00000084234	euGenes: HUgn334
ECgene: APLP2	H-InvDB: APLP2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for APLP2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for APLP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for APLP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for APLP2		Antibodies for APLP2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for APLP2		Browse small molecules at Sigma-Aldrich
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	Antibodies		Primer Pairs
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Antibodies for APLP2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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APLP2 Gene at Home site.
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APLP2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for APLP2

Summaries
for APLP2

Genomic Location
for APLP2

Proteins
for APLP2

Protein Domains/
Families
for APLP2

Gene Function
for APLP2

Pathways & Interactions
for APLP2

Drugs & Compounds
for APLP2

Transcripts
for APLP2

Expression
for APLP2

Orthologs
for APLP2

Paralogs
for APLP2

SNPs/Variants
for APLP2

Disorders & Mutations
for APLP2

Medical News
for APLP2

Publications
for APLP2

Search for APLP2

Genome Databases showing APLP2

Other Databases showing APLP2

Specialized Databases showing APLP2

Licensable Technologies
for APLP2

Services
for APLP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

APLP2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor APLP2

Summariesfor APLP2

Genomic Locationfor APLP2

Proteinsfor APLP2

Protein Domains/Familiesfor APLP2

Gene Functionfor APLP2

Pathways & Interactionsfor APLP2

Drugs & Compoundsfor APLP2

Transcriptsfor APLP2

Expression for APLP2

Orthologsfor APLP2

Paralogsfor APLP2

SNPs/Variantsfor APLP2

Disorders & Mutationsfor APLP2

Medical Newsfor APLP2

Publicationsfor APLP2

Search for APLP2

Genome Databases showing APLP2

Other Databases showing APLP2

Specialized Databases showing APLP2

Licensable Technologiesfor APLP2

Servicesfor APLP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for APLP2

Summaries
for APLP2

Genomic Location
for APLP2

Proteins
for APLP2

Protein Domains/
Families
for APLP2

Gene Function
for APLP2

Pathways & Interactions
for APLP2

Drugs & Compounds
for APLP2

Transcripts
for APLP2

Expression
for APLP2

Orthologs
for APLP2

Paralogs
for APLP2

SNPs/Variants
for APLP2

Disorders & Mutations
for APLP2

Medical News
for APLP2

Publications
for APLP2

Licensable Technologies
for APLP2

Services
for APLP2