Aliases for APLP2 Gene
External Ids for APLP2 Gene
Previous HGNC Symbols for APLP2 Gene
Previous GeneCards Identifiers for APLP2 Gene
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
GeneCards Summary for APLP2 Gene
APLP2 (Amyloid Beta (A4) Precursor-Like Protein 2) is a Protein Coding gene. Diseases associated with APLP2 include spinocerebellar ataxia 7 and alzheimer disease. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include identical protein binding and serine-type endopeptidase inhibitor activity. An important paralog of this gene is APLP1.
UniProtKB/Swiss-Prot for APLP2 Gene
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5-GTCACATG-3(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).