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Aliases for APLP1 Gene

Aliases for APLP1 Gene

  • Amyloid Beta Precursor Like Protein 1 2 3
  • Amyloid Beta (A4) Precursor-Like Protein 1 2 3 5
  • Amyloid Precursor-Like Protein 1 2 3
  • APLP 3 4
  • Amyloid-Like Protein 1 2
  • APLP-1 4

External Ids for APLP1 Gene

Previous GeneCards Identifiers for APLP1 Gene

  • GC19P036998
  • GC19P036808
  • GC19P041035
  • GC19P041051
  • GC19P036359
  • GC19P032864
  • GC19P035880

Summaries for APLP1 Gene

Entrez Gene Summary for APLP1 Gene

  • This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for APLP1 Gene

APLP1 (Amyloid Beta Precursor Like Protein 1) is a Protein Coding gene. Diseases associated with APLP1 include Alzheimer Disease. GO annotations related to this gene include identical protein binding and alpha-2A adrenergic receptor binding. An important paralog of this gene is APP.

UniProtKB/Swiss-Prot for APLP1 Gene

  • May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.

  • The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.

Gene Wiki entry for APLP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APLP1 Gene

Genomics for APLP1 Gene

Regulatory Elements for APLP1 Gene

Enhancers for APLP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APLP1 on UCSC Golden Path with GeneCards custom track

Promoters for APLP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APLP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for APLP1 Gene

Chromosome:
19
Start:
35,867,899 bp from pter
End:
35,879,797 bp from pter
Size:
11,899 bases
Orientation:
Plus strand

Genomic View for APLP1 Gene

Genes around APLP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APLP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APLP1 Gene

Proteins for APLP1 Gene

  • Protein details for APLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51693-APLP1_HUMAN
    Recommended name:
    Amyloid-like protein 1
    Protein Accession:
    P51693
    Secondary Accessions:
    • O00113
    • Q96A92

    Protein attributes for APLP1 Gene

    Size:
    650 amino acids
    Molecular mass:
    72176 Da
    Quaternary structure:
    • Monomer and homodimer. Heparin binding promotes homodimerization. Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB and APBA family members, MAPK8IP1 and Dab1 (By similarity). Binding to Dab1 inhibits its serine phosphorylation (By similarity). Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts (via NPXY motif) with DAB1 (By similarity).
    Miscellaneous:
    • Binds zinc and copper in the extracellular domain. Zinc-binding increases heparin binding. No Cu(2+) reducing activity with copper-binding.

    Three dimensional structures from OCA and Proteopedia for APLP1 Gene

    Alternative splice isoforms for APLP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APLP1 Gene

Proteomics data for APLP1 Gene at MOPED

Post-translational modifications for APLP1 Gene

  • N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.
  • Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).
  • Glycosylation at Thr 215, Ser 227, Thr 228, Asn 337, Asn 461, and Asn 551
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for APLP1 Gene

Domains & Families for APLP1 Gene

Suggested Antigen Peptide Sequences for APLP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51693

UniProtKB/Swiss-Prot:

APLP1_HUMAN :
  • The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis.
  • Belongs to the APP family.
Domain:
  • The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis.
Family:
  • Belongs to the APP family.
genes like me logo Genes that share domains with APLP1: view

No data available for Gene Families for APLP1 Gene

Function for APLP1 Gene

Molecular function for APLP1 Gene

GENATLAS Biochemistry:
amyloid beta (A4) precursor protein-like 1,expressed in brain
UniProtKB/Swiss-Prot Function:
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
UniProtKB/Swiss-Prot Function:
The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.

Gene Ontology (GO) - Molecular Function for APLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
GO:0031695 alpha-2B adrenergic receptor binding IPI 16531006
genes like me logo Genes that share ontologies with APLP1: view
genes like me logo Genes that share phenotypes with APLP1: view

Animal Models for APLP1 Gene

MGI Knock Outs for APLP1:

Animal Model Products

miRNA for APLP1 Gene

miRTarBase miRNAs that target APLP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APLP1 Gene

Localization for APLP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APLP1 Gene

Cell membrane; Single-pass type I membrane protein.
C30: Cytoplasm. Note=C-terminally processed in the Golgi complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APLP1 Gene COMPARTMENTS Subcellular localization image for APLP1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endosome 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for APLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048471 perinuclear region of cytoplasm IDA 16531006
genes like me logo Genes that share ontologies with APLP1: view

Pathways & Interactions for APLP1 Gene

SuperPathways for APLP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for APLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with APLP1: view

No data available for Pathways by source and SIGNOR curated interactions for APLP1 Gene

Drugs & Compounds for APLP1 Gene

(3) Drugs for APLP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 761,246
Copper Pharma 161

(1) Additional Compounds for APLP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APLP1: view

Transcripts for APLP1 Gene

Unigene Clusters for APLP1 Gene

Amyloid beta (A4) precursor-like protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APLP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: -
SP3:

Relevant External Links for APLP1 Gene

GeneLoc Exon Structure for
APLP1
ECgene alternative splicing isoforms for
APLP1

Expression for APLP1 Gene

mRNA expression in normal human tissues for APLP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APLP1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.7), Brain - Substantia nigra (x5.7), Brain - Putamen (basal ganglia) (x4.2), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for APLP1 Gene

This gene is overexpressed in Cerebrospinal fluid (49.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APLP1 Gene



SOURCE GeneReport for Unigene cluster for APLP1 Gene Hs.74565

mRNA Expression by UniProt/SwissProt for APLP1 Gene

P51693-APLP1_HUMAN
Tissue specificity: Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
genes like me logo Genes that share expression patterns with APLP1: view

Primer Products

No data available for Protein tissue co-expression partners for APLP1 Gene

Orthologs for APLP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for APLP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APLP1 35
  • 89.13 (n)
  • 90.8 (a)
APLP1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APLP1 35
  • 90.67 (n)
  • 92.92 (a)
APLP1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aplp1 35
  • 86.97 (n)
  • 89.38 (a)
Aplp1 16
Aplp1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APLP1 35
  • 99.28 (n)
  • 99.23 (a)
APLP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aplp1 35
  • 87.55 (n)
  • 90 (a)
oppossum
(Monodelphis domestica)
Mammalia APLP1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APLP1 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APLP1 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aplp1 35
  • 57.14 (n)
  • 51.81 (a)
zebrafish
(Danio rerio)
Actinopterygii aplp1 35
  • 61.25 (n)
  • 58.03 (a)
Dr.28171 35
aplp1 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Appl 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apl-1 36
  • 21 (a)
OneToMany
Species with no ortholog for APLP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APLP1 Gene

ENSEMBL:
Gene Tree for APLP1 (if available)
TreeFam:
Gene Tree for APLP1 (if available)

Paralogs for APLP1 Gene

Paralogs for APLP1 Gene

(2) SIMAP similar genes for APLP1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with APLP1: view

Variants for APLP1 Gene

Sequence variations from dbSNP and Humsavar for APLP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8103447 -- 35,877,215(+) GAGGC(A/G)CGGTG intron-variant
rs16970735 -- 35,876,911(+) GAAGC(A/G/T)CAAGG intron-variant
rs16970737 -- 35,877,146(+) TTGTG(G/T)CTTTC intron-variant
rs71167572 -- 35,875,180(+) TTTTT(-/T)GAGAC intron-variant
rs139935642 -- 35,871,677(+) GATCG(G/T)TTCCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for APLP1 Gene

Variant ID Type Subtype PubMed ID
nsv911638 CNV Loss 21882294
dgv51n68 CNV Loss 17160897
nsv911639 CNV Loss 21882294
nsv911640 CNV Loss 21882294

Variation tolerance for APLP1 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for APLP1 Gene

Disorders for APLP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for APLP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search APLP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for APLP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APLP1
genes like me logo Genes that share disorders with APLP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APLP1 Gene

Publications for APLP1 Gene

  1. Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. (PMID: 9521588) Lenkkeri U. … Tryggvason K. (Hum. Genet. 1998) 3 4 23 67
  2. The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. (PMID: 8432545) Wasco W. … Tanzi R.E. (Genomics 1993) 2 3 23
  3. Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2. (PMID: 19126676) Kaden D. … Multhaup G. (J. Cell. Sci. 2009) 3 23
  4. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. (PMID: 19401174) Minogue A.M. … Walsh D.M. (Brain Res. 2009) 3 23
  5. Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract. (PMID: 18430897) Arvidsson Y. … Nilsson O. (Endocr. Relat. Cancer 2008) 3 23

Products for APLP1 Gene

Sources for APLP1 Gene

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