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APLP1 Gene

protein-coding   GIFtS: 57
GCID: GC19P036359

Amyloid Beta (A4) Precursor-Like Protein 1

  See APLP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Amyloid Beta (A4) Precursor-Like Protein 11 2
APLP2 3 5
Amyloid Precursor-Like Protein 11 2
Amyloid-Like Protein 11 2
APLP-12 3

External Ids:    HGNC: 5971   Entrez Gene: 3332   Ensembl: ENSG000001052907   OMIM: 1047755   UniProtKB: P516933   

Export aliases for APLP1 gene to outside databases

Previous GC identifers: GC19P036998 GC19P036808 GC19P041035 GC19P041051 GC19P032864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APLP1 Gene:
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a
membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor
protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional
activator. The encoded protein may also play a role in synaptic maturation during cortical development.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,
Jul 2008)

GeneCards Summary for APLP1 Gene:
APLP1 (amyloid beta (A4) precursor-like protein 1) is a protein-coding gene. Diseases associated with APLP1 include alzheimer's disease. GO annotations related to this gene include transition metal ion binding and identical protein binding. An important paralog of this gene is APP.

UniProtKB/Swiss-Prot: APLP1_HUMAN, P51693
Function: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1,
activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal
transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate
neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I
Function: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis (By similarity)

Gene Wiki entry for APLP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the APLP1 gene promoter:
         E2F-1   E2F   p53   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): APLP1 promoter sequence
   Search Chromatin IP Primers for APLP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APLP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q

APLP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APLP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036359:  view genomic region     (about GC identifiers)

Start:
36,358,801 bp from pter      End:
36,370,699 bp from pter
Size:
11,899 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APLP1_HUMAN, P51693 (See protein sequence)
Recommended Name: Amyloid-like protein 1 precursor  
Size: 650 amino acids; 72176 Da
Subunit: Monomer and homodimer. Heparin binding promotes homodimerization. Binds, via its C-terminus, to the PID
domain of several cytoplasmic proteins, including APBB and APBA family members, MAPK8IP1 and Dab1 (By
similarity). Binding to Dab1 inhibits its serine phosphorylation (By similarity). Interacts with CPEB1. Interacts
(via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY
motif. Interacts (via NPXY motif) with DAB1 (By similarity)
Miscellaneous: Binds zinc and copper in the extracellular domain. Zinc-binding increases heparin binding. No
Cu(2+) reducing activity with copper-binding
4 PDB 3D structures from and Proteopedia for APLP1:
3PMR (3D)        3Q7G (3D)        3Q7L (3D)        3QMK (3D)    
Secondary accessions: O00113 Q96A92
Alternative splicing: 2 isoforms:  P51693-1   P51693-2   

Explore the universe of human proteins at neXtProt for APLP1: NX_P51693

Explore proteomics data for APLP1 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By
    similarity)1
  • N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the
    preferred site to Thr-2281
  • Glycosylation2 at Thr215, Ser227, Thr228, Asn337, Asn461, Asn551
  • Modification sites at PhosphoSitePlus

  • See APLP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019978.1  NP_005157.1  

    ENSEMBL proteins: 
     ENSP00000441501   ENSP00000221891   ENSP00000466623   ENSP00000465694   ENSP00000466116  
     ENSP00000467854   ENSP00000466576   ENSP00000474762  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR024329 Amyloid_glyco_E2_domain
     IPR008154 Amyloid_glyco_extra
     IPR011178 Amyloid_glyco_Cu-bd
     IPR019745 Amyloid_glyco_intracell_CS
     IPR008155 Amyloid_glyco

    Graphical View of Domain Structure for InterPro Entry P51693

    ProtoNet protein and cluster: P51693

    1 Blocks protein domain: IPB008155 Amyloidogenic glycoprotein (Amyloid A4)

    UniProtKB/Swiss-Prot: APLP1_HUMAN, P51693
    Domain: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific
    binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often
    required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis
    Similarity: Belongs to the APP family


    Find genes that share domains with APLP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APLP1_HUMAN, P51693
    Function: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1,
    activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal
    transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate
    neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I
    Function: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis (By similarity)

         Genatlas biochemistry entry for APLP1:
    amyloid beta (A4) precursor protein-like 1,expressed in brain

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16169070
    GO:0008201heparin binding IEA--
    GO:0031694alpha-2A adrenergic receptor binding IPI16531006
    GO:0031695alpha-2B adrenergic receptor binding IPI16531006
    GO:0031696alpha-2C adrenergic receptor binding IPI16531006
         
    Find genes that share ontologies with APLP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for APLP1:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Aplp1):
     growth/size/body  mortality/aging 

    Find genes that share phenotypes with APLP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aplp1tm1Umu for APLP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APLP1
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    miRNA
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    miRTarBase miRNAs that target APLP1:
    hsa-mir-335-5p (MIRT016721), hsa-mir-484 (MIRT041986)

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    3 qRT-PCR Assays for microRNAs that regulate APLP1:
    hsa-miR-203 hsa-miR-3170 hsa-miR-3179
    SwitchGear 3'UTR luciferase reporter plasmidAPLP1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APLP1_HUMAN, P51693: Cell membrane; Single-pass type I membrane protein
    APLP1_HUMAN, P51693: C30: Cytoplasm. Note=C-terminally processed in the Golgi complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    golgi apparatus2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane TAS9521588
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IDA16531006
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with APLP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including APLP1: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for APLP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for APLP1 (P516931, 2, 3 ENSP000002218914) via UniProtKB, MINT, STRING, and/or I2D (see all 122)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF24P170281, 2, 3EBI-74648,EBI-707773 MINT-63499 I2D: score=5 
    CSNK2BP678702, 3MINT-8253022 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253022 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253022 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253022 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006378mRNA polyadenylation IEA--
    GO:0006417regulation of translation IEA--
    GO:0006897endocytosis IEA--
    GO:0006915apoptotic process IEA--
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with APLP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APLP1

    2 HMDB Compounds for APLP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    HeparinArteven (see all 17)9005-49-6--

    4 Novoseek inferred chemical compound relationships for APLP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 31.9 7 14597230 (3), 9121703 (2), 16150056 (1)
    zinc 13.8 4 7929392 (3)
    heparin 6.07 3 7929392 (1), 7819340 (1), 8588942 (1)
    copper 0 1 15465814 (1)



    Find genes that share compounds with APLP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APLP1 gene (2 alternative transcripts): 
    NM_001024807.1  NM_005166.3  

    Unigene Cluster for APLP1:

    Amyloid beta (A4) precursor-like protein 1
    Hs.74565  [show with all ESTs]
    Unigene Representative Sequence: NM_001024807
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537454 ENST00000221891(uc010xsz.2 uc002oce.3 uc002ocf.3 uc002ocg.3 uc010xta.2)
    ENST00000590561 ENST00000586861 ENST00000589743 ENST00000592316 ENST00000588808
    ENST00000589298 ENST00000587274 ENST00000590926 ENST00000591165
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      QuantiFast Probe-based Assays in human, mouse, rat APLP1

    Additional mRNA sequence: 

    AK092376.1 AK297339.1 AK297640.1 AK312292.1 BC012889.1 BC013850.1 BC032983.1 EF036503.1 
    U48437.1 

    11 DOTS entries:

    DT.100802232  DT.447930  DT.100823207  DT.95086135  DT.95270552  DT.100823211  DT.100823213  DT.92370024 
    DT.92444425  DT.100823204  DT.101966404 

    Selected AceView cDNA sequences (see all 376):

    BM894059 BQ424122 BU931572 CD108587 BQ268342 T33735 BG060075 BU848812 
    T33797 BQ267963 T15488 BM694794 T33025 BU731303 BE382753 AK126907 
    BU073134 F02502 BQ267933 BM565577 BQ217224 BU077559 CB155222 BQ267332 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for APLP1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
    SP1:        -                                                                                   -                           
    SP2:                                                                                            -                           
    SP3:                                                                                                                        


    ECgene alternative splicing isoforms for APLP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APLP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCCTACT
    APLP1 Expression
    About this image


    APLP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
    APLP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APLP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.74565

    UniProtKB/Swiss-Prot: APLP1_HUMAN, P51693
    Tissue specificity: Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD)

        Pathway & Disease-focused RT2 Profiler PCR Array including APLP1: 
              Alzheimer's Disease in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for APLP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aplp11 , 5 amyloid beta (A4) precursor-like protein 11, 5 86.97(n)1
    89.38(a)1
      7 (18.32 cM)5
    118031  NM_007467.31  NP_031493.21 
     304349815 
    lizard
    (Anolis carolinensis)
    Reptilia APLP16
    amyloid beta (A4) precursor-like protein 1
    36(a)
    1 ↔ 1
    GL343276.1(1274893-1332462)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aplp11 amyloid beta (A4) precursor-like protein 1 57.14(n)
    51.81(a)
      100151735  NM_001127434.1  NP_001120906.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.281712 Danio rerio amyloid precursor-like protein 2 (aplp2) more 76.24(n)    AY271745.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Appl6
    beta amyloid protein precursor-like
    17(a)
    1 → many
    X(424503-473077)
    worm
    (Caenorhabditis elegans)
    Secernentea apl-16
    Protein APL-1, isoform b (apl-1) mRNA, complete cd...
    21(a)
    1 → many
    X(5112434-5116866) WBGene00000149


    ENSEMBL Gene Tree for APLP1 (if available)
    TreeFam Gene Tree for APLP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APLP1 gene
    APP2  APLP22  
    2 SIMAP similar genes for APLP1 using alignment to 8 protein entries:     APLP1_HUMAN (see all proteins):
    APLP2    APP

    Find genes that share paralogs with APLP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APLP1 (see all 368)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2302601,2
    C,F,A,H--36358563(+) ACACAT/CGAGTT 2 -- us2k116Minor allele frequency- C:0.21NS EA NA WA CSA 1985
    rs1390198511,2
    --36358589(+) ACACAC/GATAGG 2 -- us2k10--------
    rs1813720921,2
    --36358613(+) ACACAC/TGCATA 2 -- us2k10--------
    rs1419458681,2
    --36358793(+) AGATCC/GAGACC 2 -- us2k10--------
    rs1863600751,2
    --36358798(+) CAGACA/CCTAAT 2 -- us2k10--------
    rs600922211,2
    C,F--36358923(+) GGCCCC/GTGGGA 2 -- us2k14Minor allele frequency- G:0.14WA EA 242
    rs1904990441,2
    --36359046(+) GGAAGA/GGACTA 2 -- us2k10--------
    rs1820416271,2
    --36359281(+) GGCGGA/GACGCC 2 -- us2k10--------
    rs115509991,2
    C--36359650(+) CCATCG/AGGAGC 4 /R /G mis11Minor allele frequency- A:0.00NA 2
    rs781672691,2
    C,F--36359842(+) CCAGGC/TCCCAG 2 -- int11Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for APLP1 (36358801 - 36370699 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for APLP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911640CNV Loss21882294
    nsv911639CNV Loss21882294
    dgv51n68CNV Loss17160897
    nsv911638CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APLP1
    DNA2.0 Custom Variant and Variant Library Synthesis for APLP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 104775    OMIM disorders: --

    1 disease for APLP1:    
    About MalaCards
    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for APLP1:
    Alzheimer's disease

    Find genes that share disorders with APLP1           About GenesLikeMe

    3 Novoseek inferred disease relationships for APLP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 71.1 12 9444352 (2), 9521588 (1), 10578233 (1), 10676850 (1) (see all 8)
    senile plaques 53.2 3 9444352 (2), 9729270 (1)
    amyloidosis 44.4 1 10676850 (1)


    Export disorders for APLP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APLP1 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with APLP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. (PubMed id 9521588)1, 2, 9 Lenkkeri U.... Tryggvason K. (Hum. Genet. 1998)
    2. Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. (PubMed id 7494461)1, 2, 9 Kim T.-W....Black I.B. (Brain Res. Mol. Brain Res. 1995)
    3. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. (PubMed id 7929392)1, 2, 9 Bush A.I.... Wasco W. (J. Biol. Chem. 1994)
    4. Human amyloid precursor-like protein 1 -- cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. (PubMed id 9428684)1, 2, 9 Paliga K.... Weidemann A. (Eur. J. Biochem. 1997)
    5. The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. (PubMed id 8432545)1, 3, 9 Wasco W....Tanzi R.E. (Genomics 1993)
    6. The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization. (PubMed id 21574595)1, 2 Lee S.... Ha Y. (Biochemistry 2011)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Evidence for a copper-binding superfamily of the amyloid precursor protein. (PubMed id 12135352)1, 2 Simons A.... Multhaup G. (Biochemistry 2002)
    9. Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. (PubMed id 9890987)1, 2 Tomita S.... Suzuki T. (J. Biol. Chem. 1999)
    10. Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract. (PubMed id 18430897)1, 9 Arvidsson Y....Nilsson O. (Endocr. Relat. Cancer 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 333 HGNC: 597 AceView: APLP1 Ensembl:ENSG00000105290 euGenes: HUgn333
    ECgene: APLP1 H-InvDB: APLP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for APLP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for APLP1 gene:
    Search GeneIP for patents involving APLP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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