Aliases for APLP1 Gene
External Ids for APLP1 Gene
Previous GeneCards Identifiers for APLP1 Gene
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for APLP1 Gene
APLP1 (Amyloid Beta (A4) Precursor-Like Protein 1) is a Protein Coding gene. Diseases associated with APLP1 include alzheimer disease. GO annotations related to this gene include identical protein binding and transition metal ion binding. An important paralog of this gene is APP.
UniProtKB/Swiss-Prot for APLP1 Gene
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.