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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APLP1 Gene

protein-coding   GIFtS: 56
GCID: GC19P036359

amyloid beta (A4) precursor-like protein 1
 Explore 12 diseases affiliated with
APLP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for APLP1    

Aliases
for APLP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Amyloid Beta (A4) Precursor-Like Protein 11 2
APLP1 2 3 5
APLP-12 3
Amyloid Precursor-Like Protein 12
Amyloid-Like Protein 12

External Ids:    HGNC: 5971   Entrez Gene: 3332   Ensembl: ENSG000001052907   OMIM: 1047755   UniProtKB: P516933   

Export aliases for APLP1 gene to outside databases

Previous GC identifers: GC19P036998 GC19P036808 GC19P041035 GC19P041051 GC19P032864


Summaries
for APLP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for APLP1:
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a
membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor
protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional
activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively
spliced transcript variants encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: APLP1_HUMAN, P51693
Function: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates
transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through
C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through
binding to components of the extracellular matrix such as heparin and collagen I
Function: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis (By similarity)

Gene Wiki entry for APLP1


Genomic Views
for APLP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APLP1 gene promoter:
         E2F-1   E2F   p53   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): APLP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for APLP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APLP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q

APLP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APLP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036359:  view genomic region     (about GC identifiers)

Start:
 36,358,801 bp from pter      End:
 36,370,699 bp from pter
Size:
 11,899 bases      Orientation:
 plus strand

Proteins
for APLP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: APLP1_HUMAN, P51693 (See protein sequence)
Recommended Name: Amyloid-like protein 1 precursor  
Size: 650 amino acids; 72176 Da
Subunit: Monomer and homodimer. Heparin binding promotes homodimerization. Binds, via its C-terminus, to the PID domain
of several cytoplasmic proteins, including APBB and APBA family members, MAPK8IP1 and Dab1 (By similarity). Binding to
Dab1 inhibits its serine phosphorylation (By similarity). Interacts with CPEB1. Interacts (via NPXY motif) with DAB2
(via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts (via NPXY
motif) with DAB1 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Subcellular location: C30: Cytoplasm. Note=C-terminally processed in the Golgi complex
Miscellaneous: Binds zinc and copper in the extracellular domain. Zinc-binding increases heparin binding. No Cu(2+)
reducing activity with copper-binding
4 PDB 3D structures from and Proteopedia for APLP1:
3PMR (3D)        3Q7G (3D)        3Q7L (3D)        3QMK (3D)    
Secondary accessions: O00113 Q96A92
Alternative splicing: 2 isoforms:  P51693-1   P51693-2   

Explore the universe of human proteins at neXtProt for APLP1: NX_P51693

Post-translational modifications:

  • Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By
    • similarity)1
  • N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the
    • preferred site to Thr-2281
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51693

    • APLP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019978.1  NP_005157.1  

    ENSEMBL proteins: 
     ENSP00000441501   ENSP00000221891   ENSP00000466623   ENSP00000465694   ENSP00000466116  
     ENSP00000467854   ENSP00000466576  

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    Uscn Proteins for APLP1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane TAS9521588
    GO:0005624membrane fraction ----
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IDA16531006
    GO:0016021integral to membrane IEA--


    APLP1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for APLP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    APLP1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR024329 Amyloid_glyco_E2_domain
     IPR019745 Amyloid_glyco_intracell_CS
     IPR008155 Amyloid_glyco
     IPR008154 Amyloid_glyco_extra
     IPR019744 Amyloid_glyco_extracell_CS

    Graphical View of Domain Structure for InterPro Entry P51693

    ProtoNet protein and cluster: P51693

    1 Blocks protein family: IPB008155 Amyloidogenic glycoprotein (Amyloid A4)

    UniProtKB/Swiss-Prot: APLP1_HUMAN, P51693
    Domain: The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of
    the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for
    complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis
    Similarity: Belongs to the APP family


    Function
    for APLP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: APLP1_HUMAN, P51693
    Function: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates
    transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through
    C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through
    binding to components of the extracellular matrix such as heparin and collagen I
    Function: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis (By similarity)

         Genatlas biochemistry entry for APLP1:
    amyloid beta (A4) precursor protein-like 1,expressed in brain

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    Gene Editing
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16193067
    GO:0008201heparin binding IEA--
    GO:0031694alpha-2A adrenergic receptor binding IPI16531006
    GO:0031695alpha-2B adrenergic receptor binding IPI16531006
    GO:0031696alpha-2C adrenergic receptor binding IPI16531006


    APLP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for APLP1:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Aplp1tm1Umu for APLP1
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Aplp1):
     growth/size  mortality/aging 

    APLP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for APLP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APLP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/77 Interacting proteins for APLP1 (P516931, 2, 3 ENSP000002218914) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF24P170281, 2, 3EBI-74648,EBI-707773 MINT-63499 I2D: score=5 
    TK1P041832, 3MINT-63366 MINT-8272916 I2D: score=5 
    TSC22D1Q157142, 3MINT-64575 MINT-8275226 I2D: score=5 
    EEF1A1P681042, 3, ENSP000003300544MINT-3979859 I2D: score=2 STRING: ENSP00000330054
    GDF9O603832, 3, ENSP000002968754MINT-3979842 I2D: score=2 STRING: ENSP00000296875
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006378mRNA polyadenylation IEA--
    GO:0006417regulation of translation IEA--
    GO:0006897endocytosis IEA--
    GO:0006915apoptotic process IEA--
    GO:0007155cell adhesion IEA--


    APLP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for APLP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APLP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for APLP1

    2 HMDB Compounds for APLP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    HeparinArteven (see all 17)9005-49-6--
    4 Novoseek chemical compound relationships for APLP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 31.9 7 14597230 (3), 9121703 (2), 16150056 (1)
    zinc 13.8 4 7929392 (3)
    heparin 6.07 3 7929392 (1), 7819340 (1), 8588942 (1)
    copper 0 1 15465814 (1)

    Search CenterWatch for drugs/clinical trials and news about APLP1 

    Transcripts
    for APLP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APLP1 gene (2 alternative transcripts): 
    NM_001024807.1  NM_005166.3  

    Unigene Cluster for APLP1:

    Amyloid beta (A4) precursor-like protein 1
    Hs.74565  [show with all ESTs]
    Unigene Representative Sequence: NM_001024807
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537454 ENST00000221891(uc010xsz.2 uc002oce.3 uc002ocf.3 uc002ocg.3 uc010xta.2)
    ENST00000590561 ENST00000586861 ENST00000589743 ENST00000592316 ENST00000588808
    ENST00000589298 ENST00000587274 ENST00000588987 ENST00000590926 ENST00000591165


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK092376.1 AK297339.1 AK297640.1 AK312292.1 BC012889.1 BC013850.1 BC032983.1 EF036503.1 
    U48437.1 

    11 DOTS entries:

    DT.100802232  DT.447930  DT.100823207  DT.95086135  DT.95270552  DT.100823211  DT.100823213  DT.92370024 
    DT.92444425  DT.100823204  DT.101966404 

    24/376 AceView cDNA sequences (see all 376):

    BQ267332 F02310 T33735 BM508128 BQ424122 AA911127 T34795 BC012889 
    BQ268220 BQ898546 BQ267951 CD108587 BM565577 AK126907 BI468319 T33361 
    CB155222 BM479482 CA390221 BM894059 CA841317 NM_005166 BU071125 BI824800 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for APLP1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
    SP1:        -                                                                                   -                           
    SP2:                                                                                            -                           
    SP3:                                                                                                                        


    ECgene alternative splicing isoforms for APLP1

    Expression
    for APLP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APLP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCCCTACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    APLP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See APLP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APLP1

    SOURCE GeneReport for Unigene cluster: Hs.74565

    UniProtKB/Swiss-Prot: APLP1_HUMAN, P51693
    Tissue specificity: Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD)

        SABiosciences Expression via Pathway-Focused PCR Array including APLP1: 
              Alzheimer's Disease in human mouse rat

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    In Situ
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    Orthologs
    for APLP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for APLP1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Aplp11 , 5 amyloid beta (A4) precursor-like protein 11, 5 86.97(n)1
    89.38(a)1    		   7 (18.32 cM)5
    118031  NM_007467.31  NP_031493.21 
     304349815 
    lizard
    (Anolis carolinensis)    		 Reptilia APLP16
    		 --
    		 36(a)
    		 1 ↔ 1
    		 GL343276.1(1292325-1332462)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.281712 Danio rerio amyloid precursor-like protein 2 (aplp2) more 76.24(n)    AY271745.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Appl6
    		 beta amyloid protein precursor-like
    		 17(a)
    		 1 → many
    		 X(424503-473077)
    worm
    (Caenorhabditis elegans)    		 Secernentea apl-16
    		 Beta-amyloid-like protein
    		 20(a)
    		 1 → many
    		 X(5112403-5116839)


    ENSEMBL Gene Tree for APLP1 (if available)
    TreeFam Gene Tree for APLP1 (if available) 

    Paralogs
    for APLP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APLP1 gene
    APP2  APLP22  
    2 SIMAP similar genes for APLP1 using alignment to 7 protein entries:     APLP1_HUMAN (see all proteins):
    APLP2    APP

    APLP1 for paralogs           About GeneDecksing



    Genomic Variants
    for APLP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/270 NCBI SNPs in APLP1 are shown (see all 270)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1923723771,2
    		--36357550(+) ATACAC/GTCAGC 5 -- ut31 us2k10--------
    rs1115130251,2
    		C,--36357595(+) TGGCCA/GCCCAA 5 -- ut31 us2k12Minor allele frequency- G:0.05WA 120
    rs1846110581,2
    		--36357780(+) TAGGAC/TAGATG 5 -- ut31 us2k10--------
    rs81126841,2
    		C,H--36357929(+) ACTCAG/AAAAGA 5 -- ut31 us2k14Minor allele frequency- A:0.00NS EA 418
    rs1890752331,2
    		--36357973(+) TACCAC/GTGTTG 5 -- ut31 us2k10--------
    rs1930030711,2
    		--36358178(+) TCTTGC/TTACCT 5 -- ds5001 us2k10--------
    rs1839475381,2
    		--36358356(+) CACCAA/CACCCA 5 -- ds5001 us2k10--------
    rs1419556141,2
    		--36358442(+) GATCCA/GCCCAC 5 -- us2k1 ds50010--------
    rs2302601,2
    		C,F,A,H,--36358563(+) ACACAA/C/G/T 
                GAGTT     		2 -- us2k116NS EA NA WA CSA 1985
    rs1390198511,2
    		--36358589(+) ACACAC/GATAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for APLP1 (36358801 - 36370699 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for APLP1
         1 CNV: 5097

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    Disorders / Diseases
    for APLP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APLP1 for disorders           About GeneDecksing

    OMIM gene information: 104775    OMIM disorders: --

    12 diseases for APLP1:    About MalaCards
    chronic fatigue syndrome    amyloidosis    lissencephaly    alzheimer's disease
    down syndrome    neurodegeneration    dementia    pharyngitis
    infertility    cerebritis    neuroblastoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for APLP1:
    Alzheimer's disease

    3 Novoseek disease relationships for APLP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 71.1 12 9444352 (2), 9521588 (1), 10578233 (1), 10676850 (1) (see all 8)
    senile plaques 53.2 3 9444352 (2), 9729270 (1)
    amyloidosis 44.4 1 10676850 (1)


    Export disorders for APLP1 gene to outside databases

    Publications
    for APLP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APLP1 gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with APLP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. (PubMed id 9521588)1, 2, 9 Lenkkeri U.... Tryggvason K. (1998)
    2. Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. (PubMed id 7494461)1, 2, 9 Kim T.-W....Black I.B. (1995)
    3. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. (PubMed id 7929392)1, 2, 9 Bush A.I.... Wasco W. (1994)
    4. Human amyloid precursor-like protein 1 -- cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. (PubMed id 9428684)1, 2, 9 Paliga K.... Weidemann A. (1997)
    5. The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. (PubMed id 8432545)1, 3, 9 Wasco W....Tanzi R.E. (1993)
    6. The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization. (PubMed id 21574595)1, 2 Lee S.... Ha Y. (2011)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Evidence for a copper-binding superfamily of the amyloid precursor protein. (PubMed id 12135352)1, 2 Simons A.... Multhaup G. (2002)
    9. Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. (PubMed id 9890987)1, 2 Tomita S.... Suzuki T. (1999)
    10. Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract. (PubMed id 18430897)1, 9 Arvidsson Y....Nilsson O. (2008)

    External Searches for APLP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing APLP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 333 HGNC: 597 AceView: APLP1 Ensembl:ENSG00000105290 euGenes: HUgn333
    ECgene: APLP1 H-InvDB: APLP1

    Other Databases showing APLP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing APLP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APLP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for APLP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for APLP1 gene:
    Search GeneIP for patents involving APLP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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