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Aliases for APLP1 Gene

Aliases for APLP1 Gene

  • Amyloid Beta (A4) Precursor-Like Protein 1 2 3
  • APLP 3 4 6
  • Amyloid Precursor-Like Protein 1 2 3
  • Amyloid-Like Protein 1 2 3
  • APLP-1 3 4

External Ids for APLP1 Gene

Previous GeneCards Identifiers for APLP1 Gene

  • GC19P036998
  • GC19P036808
  • GC19P041035
  • GC19P041051
  • GC19P036359
  • GC19P032864

Summaries for APLP1 Gene

Entrez Gene Summary for APLP1 Gene

  • This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for APLP1 Gene

APLP1 (Amyloid Beta (A4) Precursor-Like Protein 1) is a Protein Coding gene. Diseases associated with APLP1 include alzheimer disease. GO annotations related to this gene include identical protein binding and transition metal ion binding. An important paralog of this gene is APP.

UniProtKB/Swiss-Prot for APLP1 Gene

  • May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.

  • The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.

Gene Wiki entry for APLP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APLP1 Gene

Genomics for APLP1 Gene

Regulatory Elements for APLP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APLP1 Gene

Start:
35,867,899 bp from pter
End:
35,879,797 bp from pter
Size:
11,899 bases
Orientation:
Plus strand

Genomic View for APLP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APLP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APLP1 Gene

Proteins for APLP1 Gene

  • Protein details for APLP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51693-APLP1_HUMAN
    Recommended name:
    Amyloid-like protein 1
    Protein Accession:
    P51693
    Secondary Accessions:
    • O00113
    • Q96A92

    Protein attributes for APLP1 Gene

    Size:
    650 amino acids
    Molecular mass:
    72176 Da
    Quaternary structure:
    • Monomer and homodimer. Heparin binding promotes homodimerization. Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB and APBA family members, MAPK8IP1 and Dab1 (By similarity). Binding to Dab1 inhibits its serine phosphorylation (By similarity). Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif. Interacts (via NPXY motif) with DAB1 (By similarity).
    Miscellaneous:
    • Binds zinc and copper in the extracellular domain. Zinc-binding increases heparin binding. No Cu(2+) reducing activity with copper-binding

    Three dimensional structures from OCA and Proteopedia for APLP1 Gene

    Alternative splice isoforms for APLP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APLP1 Gene

Proteomics data for APLP1 Gene at MOPED

Post-translational modifications for APLP1 Gene

  • N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.
  • Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).
  • Glycosylation at Thr215, Ser227, Thr228, Asn337, Asn461, and Asn551
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for APLP1 Gene

Domains for APLP1 Gene

Suggested Antigen Peptide Sequences for APLP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51693

UniProtKB/Swiss-Prot:

APLP1_HUMAN :
  • P51693
Domain:
  • The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis
Family:
  • Belongs to the APP family.
genes like me logo Genes that share domains with APLP1: view

No data available for Gene Families for APLP1 Gene

Function for APLP1 Gene

Molecular function for APLP1 Gene

GENATLAS Biochemistry: amyloid beta (A4) precursor protein-like 1,expressed in brain
UniProtKB/Swiss-Prot Function: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
UniProtKB/Swiss-Prot Function: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.

Gene Ontology (GO) - Molecular Function for APLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
GO:0008201 heparin binding IEA --
GO:0031694 alpha-2A adrenergic receptor binding IPI 16531006
GO:0031695 alpha-2B adrenergic receptor binding IPI 16531006
GO:0031696 alpha-2C adrenergic receptor binding IPI 16531006
genes like me logo Genes that share ontologies with APLP1: view

Phenotypes for APLP1 Gene

MGI mutant phenotypes for APLP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for APLP1:
genes like me logo Genes that share phenotypes with APLP1: view

Animal Models for APLP1 Gene

MGI Knock Outs for APLP1:

Animal Model Products

CRISPR Products

miRNA for APLP1 Gene

miRTarBase miRNAs that target APLP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APLP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for APLP1 Gene

Localization for APLP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APLP1 Gene

Cell membrane; Single-pass type I membrane protein.
C30: Cytoplasm. Note=C-terminally processed in the Golgi complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APLP1 Gene COMPARTMENTS Subcellular localization image for APLP1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
golgi apparatus 2
nucleus 1

Gene Ontology (GO) - Cellular Components for APLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane TAS 9521588
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IDA 16531006
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APLP1: view

Pathways for APLP1 Gene

SuperPathways for APLP1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for APLP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IEA --
GO:0006417 regulation of translation IEA --
GO:0006897 endocytosis IEA --
GO:0006915 apoptotic process IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with APLP1: view

No data available for Pathways by source for APLP1 Gene

Compounds for APLP1 Gene

(2) HMDB Compounds for APLP1 Gene

Compound Synonyms Cas Number PubMed IDs
Copper
  • Cu
7440-50-8
Heparin
  • Arteven
9005-49-6

(4) Novoseek inferred chemical compound relationships for APLP1 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 31.9 6
zinc 13.8 3
heparin 6.07 3
copper 0 1
genes like me logo Genes that share compounds with APLP1: view

Transcripts for APLP1 Gene

Unigene Clusters for APLP1 Gene

Amyloid beta (A4) precursor-like protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APLP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APLP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: -
SP3:

Relevant External Links for APLP1 Gene

GeneLoc Exon Structure for
APLP1
ECgene alternative splicing isoforms for
APLP1

Expression for APLP1 Gene

mRNA expression in normal human tissues for APLP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APLP1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (9.7), Brain - Substantia nigra (5.7), Brain - Putamen (basal ganglia) (4.2), and Brain - Hippocampus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APLP1 Gene

SOURCE GeneReport for Unigene cluster for APLP1 Gene Hs.74565

mRNA Expression by UniProt/SwissProt for APLP1 Gene

P51693-APLP1_HUMAN
Tissue specificity: Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
genes like me logo Genes that share expressions with APLP1: view

In Situ Assay Products

Orthologs for APLP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for APLP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APLP1 35
  • 99.28 (n)
  • 99.23 (a)
APLP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APLP1 35
  • 89.13 (n)
  • 90.8 (a)
APLP1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APLP1 35
  • 90.67 (n)
  • 92.92 (a)
APLP1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aplp1 35
  • 86.97 (n)
  • 89.38 (a)
Aplp1 16
Aplp1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APLP1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APLP1 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aplp1 35
  • 87.55 (n)
  • 90 (a)
lizard
(Anolis carolinensis)
Reptilia APLP1 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aplp1 35
  • 57.14 (n)
  • 51.81 (a)
zebrafish
(Danio rerio)
Actinopterygii aplp1 35
  • 61.25 (n)
  • 58.03 (a)
aplp1 36
  • 50 (a)
OneToOne
Dr.28171 35
fruit fly
(Drosophila melanogaster)
Insecta Appl 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea apl-1 36
  • 21 (a)
OneToMany
Species with no ortholog for APLP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APLP1 Gene

ENSEMBL:
Gene Tree for APLP1 (if available)
TreeFam:
Gene Tree for APLP1 (if available)

Paralogs for APLP1 Gene

Paralogs for APLP1 Gene

Selected SIMAP similar genes for APLP1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with APLP1: view

Variants for APLP1 Gene

Sequence variations from dbSNP and Humsavar for APLP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs172985 -- 35,875,083(+) TCTTG(G/T)CCCTT intron-variant
rs230260 -- 35,867,661(+) ACACA(C/T)GAGTT upstream-variant-2KB
rs230261 -- 35,872,568(+) CTGAG(A/G)GCCAA synonymous-codon, reference
rs230262 -- 35,873,987(+) GGGCC(C/T)CTGCA intron-variant
rs230263 -- 35,874,466(+) CCCAT(A/C)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APLP1 Gene

Variant ID Type Subtype PubMed ID
nsv911638 CNV Loss 21882294
dgv51n68 CNV Loss 17160897
nsv911639 CNV Loss 21882294
nsv911640 CNV Loss 21882294

Relevant External Links for APLP1 Gene

HapMap Linkage Disequilibrium report
APLP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APLP1 Gene

Disorders for APLP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for APLP1 Gene including...

Search for APLP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for APLP1 Gene

(3) Novoseek inferred disease relationships for APLP1 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 71.1 9
senile plaques 53.2 3
amyloidosis 44.4 1
genes like me logo Genes that share disorders with APLP1: view

No data available for UniProtKB/Swiss-Prot for APLP1 Gene

Publications for APLP1 Gene

  1. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. (PMID: 7929392) Bush A.I. … Wasco W. (J. Biol. Chem. 1994) 3 4 23
  2. Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. (PMID: 7494461) Kim T.-W. … Black I.B. (Brain Res. Mol. Brain Res. 1995) 3 4 23
  3. The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. (PMID: 8432545) Wasco W. … Tanzi R.E. (Genomics 1993) 2 3 23
  4. Human amyloid precursor-like protein 1 -- cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. (PMID: 9428684) Paliga K. … Weidemann A. (Eur. J. Biochem. 1997) 3 4 23
  5. Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1. (PMID: 9521588) Lenkkeri U. … Tryggvason K. (Hum. Genet. 1998) 3 4 23

Products for APLP1 Gene

Sources for APLP1 Gene

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