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Aliases for APLNR Gene

Aliases for APLNR Gene

  • Apelin Receptor 2 3
  • AGTRL1 3 4 6
  • APJ 3 4 6
  • G-Protein Coupled Receptor HG11 3 4
  • Angiotensin II Receptor-Like 1 2 3
  • G-Protein Coupled Receptor APJ 3 4
  • Angiotensin Receptor-Like 1 3 4
  • APJ (Apelin) Receptor 2 3
  • G Protein-Coupled Receptor APJ 3
  • HG11 Orphan Receptor 3
  • APJ Receptor 3
  • APJR 3
  • HG11 3

External Ids for APLNR Gene

Previous Symbols for APLNR Gene

  • AGTRL1

Summaries for APLNR Gene

Entrez Gene Summary for APLNR Gene

  • This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]

GeneCards Summary for APLNR Gene

APLNR (Apelin Receptor) is a Protein Coding gene. Diseases associated with APLNR include hiv-1. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for APLNR Gene

  • Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia

Tocris Summary for APLNR Gene

  • Apelin-36, apelin-13 and [Pyr1]-apelin-13 are the predominant endogenous ligands for the apelin receptor (APJ receptor), a G-protein-coupled receptor with considerable sequence homology to the angiotensin (AT1) receptor. The APJ receptor and apelin peptides act as mediators of cardiovascular function, fluid homeostasis and adipocyte endocrine secretion.

Gene Wiki entry for APLNR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APLNR Gene

Genomics for APLNR Gene

Genomic Location for APLNR Gene

Start:
57,233,577 bp from pter
End:
57,237,453 bp from pter
Size:
3,877 bases
Orientation:
Minus strand

Genomic View for APLNR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APLNR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APLNR Gene

Regulatory Elements for APLNR Gene

Proteins for APLNR Gene

  • Protein details for APLNR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35414-APJ_HUMAN
    Recommended name:
    Apelin receptor
    Protein Accession:
    P35414
    Secondary Accessions:

    Protein attributes for APLNR Gene

    Size:
    380 amino acids
    Molecular mass:
    42660 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APLNR Gene

neXtProt entry for APLNR Gene

Proteomics data for APLNR Gene at MOPED

Post-translational modifications for APLNR Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn15 and Asn175

Other Protein References for APLNR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for APLNR Gene

Domains for APLNR Gene

Gene Families for APLNR Gene

Protein Domains for APLNR Gene

UniProtKB/Swiss-Prot:

APJ_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P35414
genes like me logo Genes that share domains with APLNR: view

Function for APLNR Gene

Molecular function for APLNR Gene

UniProtKB/Swiss-Prot Function: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia

Gene Ontology (GO) - Molecular Function for APLNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9792798
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with APLNR: view
genes like me logo Genes that share phenotypes with APLNR: view

Animal Models for APLNR Gene

MGI Knock Outs for APLNR:

miRNA for APLNR Gene

miRTarBase miRNAs that target APLNR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for APLNR Gene

Localization for APLNR Gene

Subcellular locations from UniProtKB/Swiss-Prot for APLNR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APLNR Gene COMPARTMENTS Subcellular localization image for APLNR gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for APLNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8294032
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with APLNR: view

Pathways for APLNR Gene

genes like me logo Genes that share pathways with APLNR: view

Pathways by source for APLNR Gene

Interacting Proteins for APLNR Gene

Gene Ontology (GO) - Biological Process for APLNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007369 gastrulation IEA --
GO:0007507 heart development ISS --
GO:0050878 regulation of body fluid levels IEA --
GO:0050909 sensory perception of taste --
genes like me logo Genes that share ontologies with APLNR: view

Compounds for APLNR Gene

(5) Tocris Compounds for APLNR Gene

Compound Action Cas Number
[Pyr1]-Apelin-13 Potent peptide agonist for APJ receptor [217082-60-5]
Apelin-17 (human, bovine) Endogenous APJ receptor agonist [217082-57-0]
Apelin-36 (human) Endogenous APJ receptor agonist [252642-12-9]
Apelin-36 (rat, mouse) Endogenous APJ receptor agonist [230299-95-3]
ML 221 Apelin receptor (APJ) antagonist [877636-42-5]

(17) IUPHAR Ligand for APLNR Gene

Ligand Type Action Affinity Pubmed IDs
[125I][Nle75,Tyr77]apelin-36 (human) Agonist Full agonist 11.2
[125I][Glp65Nle75,Tyr77]apelin-13 Agonist Full agonist 10.7
apelin-13 Agonist Full agonist 9.5
[125I](Pyr1)apelin-13 Agonist Full agonist 9.5
[125I]apelin-13 Agonist Full agonist 9.2
apelin-17 Agonist Agonist 9.02
[Pyr1]apelin-13 Agonist Full agonist 8.8
apelin-36 Agonist Full agonist 8.6
[3H](Pyr1)[Met(0)11]-apelin-13 Agonist Full agonist 8.6
MM54 Antagonist Antagonist 8.15
cyclo apelin-12 (7-12) Agonist Full agonist 7.1
cyclourea apelin-12 (1-7) Agonist Full agonist 6.84
E339-3D6 Agonist Agonist 6.4
cyclo apelin-12 (1-12) Agonist Full agonist 6.31
ALX40-4C Agonist Partial agonist 6.1
ML221 Antagonist Antagonist
ML233 Agonist Full agonist

(1) Novoseek inferred chemical compound relationships for APLNR Gene

Compound -log(P) Hits PubMed IDs
tyrosine 0 1
genes like me logo Genes that share compounds with APLNR: view

Transcripts for APLNR Gene

mRNA/cDNA for APLNR Gene

Unigene Clusters for APLNR Gene

Apelin receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APLNR Gene

No ASD Table

Relevant External Links for APLNR Gene

GeneLoc Exon Structure for
APLNR
ECgene alternative splicing isoforms for
APLNR

Expression for APLNR Gene

mRNA expression in normal human tissues for APLNR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APLNR Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (9.4), Spleen (5.3), and Brain - Hypothalamus (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APLNR Gene

SOURCE GeneReport for Unigene cluster for APLNR Gene Hs.438311

mRNA Expression by UniProt/SwissProt for APLNR Gene

P35414-APJ_HUMAN
Tissue specificity: Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon
genes like me logo Genes that share expressions with APLNR: view

Orthologs for APLNR Gene

This gene was present in the common ancestor of chordates.

Orthologs for APLNR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APLNR 36
  • 99.56 (n)
  • 99.74 (a)
APLNR 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APLNR 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APLNR 36
  • 90.79 (n)
  • 93.42 (a)
APLNR 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aplnr 36
  • 87.41 (n)
  • 92.55 (a)
Aplnr 16
Aplnr 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APLNR 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aplnr 36
  • 87.32 (n)
  • 90.43 (a)
chicken
(Gallus gallus)
Aves APLNR 36
  • 71.31 (n)
  • 65.74 (a)
APLNR 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 67 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii aplnra 37
  • 48 (a)
OneToMany
aplnra 37
  • 48 (a)
OneToMany
aplnrb 37
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToMany
Species with no ortholog for APLNR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APLNR Gene

ENSEMBL:
Gene Tree for APLNR (if available)
TreeFam:
Gene Tree for APLNR (if available)

Paralogs for APLNR Gene

Paralogs for APLNR Gene

genes like me logo Genes that share paralogs with APLNR: view

Variants for APLNR Gene

Sequence variations from dbSNP and Humsavar for APLNR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs746885 -- 57,234,558(+) TAGGG(A/G)GTGGA utr-variant-3-prime, intron-variant
rs746886 -- 57,234,637(+) AATGT(A/G)TGAAC utr-variant-3-prime, intron-variant
rs746887 -- 57,234,773(+) TCTCC(A/G)TCCCA utr-variant-3-prime, intron-variant
rs948846 -- 57,234,677(+) AGGAG(A/G)TTTGT intron-variant
rs948847 -- 57,236,870(+) CCGTT(G/T)CCCGT synonymous-codon, reference, nc-transcript-variant

Relevant External Links for APLNR Gene

HapMap Linkage Disequilibrium report
APLNR
Human Gene Mutation Database (HGMD)
APLNR

No data available for Structural Variations from Database of Genomic Variants (DGV) for APLNR Gene

Disorders for APLNR Gene

(1) MalaCards Diseases for APLNR Gene

Search for APLNR Gene in MalaCards »

(5) Novoseek inferred disease relationships for APLNR Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 50.6 11
heart failure 23.4 4
virus infection 0 2
hiv infections 0 2
tumors 0 2

Relevant External Links for APLNR

Genetic Association Database (GAD)
APLNR
Human Genome Epidemiology (HuGE) Navigator
APLNR
genes like me logo Genes that share disorders with APLNR: view

No data available for UniProtKB/Swiss-Prot for APLNR Gene

Publications for APLNR Gene

  1. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. (PMID: 8294032) O'Dowd B.F. … Nguyen T. (Gene 1993) 2 3 4 23
  2. Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese. (PMID: 19307984) Li W.W. … Zhu D.L. (J. Hypertens. 2009) 3 23 49
  3. Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations. (PMID: 19680269) Hinohara K. … Kimura A. (J. Hum. Genet. 2009) 3 23 49
  4. Plasma apelin levels and apelin/APJ mRNA expression in patients with gestational diabetes mellitus. (PMID: 19926159) Telejko B. … Gorska M. (Diabetes Res. Clin. Pract. 2010) 3 23
  5. [Apelin signalisation and vascular physiopathology]. (PMID: 19527631) Masri B. … Audigier Y. (J. Soc. Biol. 2009) 3 23

Products for APLNR Gene

Sources for APLNR Gene

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