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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APLNR Gene

protein-coding GIFtS: 62
GCID: GC11M057001

apelin receptor

(Previous name: angiotensin II receptor-like 1 )
(Previous symbol: AGTRL1)

Explore 19 diseases affiliated with
APLNR via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Apelin Receptor¹ ²		G-Protein Coupled Receptor HG11² ³
AGTRL1¹ ² ³ ⁵		FLJ90771¹
APJ¹ ² ³ ⁵		HG11²
APJR¹ ²		APJ (Apelin) Receptor²
Angiotensin II Receptor-Like 1¹ ²		APJ Receptor²
Angiotensin Receptor-Like 1² ³		G Protein-Coupled Receptor APJ²
G-Protein Coupled Receptor APJ² ³		HG11 Orphan Receptor²

External Ids:	HGNC: 339¹	Entrez Gene: 187²	Ensembl: ENSG00000134817⁷	OMIM: 600052⁵	UniProtKB: P35414³

ORGUL members:
	NONCODE:n408083

Export aliases for APLNR gene to outside databases

Previous GC identifers: GC11M056758 GC11M053349

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APLNR:

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the

angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a

counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in

the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a

human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been

identified. (provided by RefSeq, Jul 2009)

UniProtKB/Swiss-Prot: APJ_HUMAN, P35414

Function: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor

with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia

summary for APLNR:

Apelin-36, apelin-13 and [Pyr1]-apelin-13 are the predominant endogenous ligands for the apelin receptor

(APJ receptor), a G-protein-coupled receptor with considerable sequence homology to the angiotensin (AT1)

receptor. The APJ receptor and apelin peptides act as mediators of cardiovascular function, fluid

homeostasis and adipocyte endocrine secretion.

Gene Wiki entry for APLNR (Apelin receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APLNR gene promoter:
ISGF-3 RREB-1 GCNF NF-AT NF-AT4 NF-AT2 GCNF-1 NF-AT3 GCNF-2 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APLNR promoter sequence

Search SABiosciences Chromatin IP Primers for APLNR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APLNR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1

APLNR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APLNR gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M057001: view genomic region (about GC identifiers)

Start:	57,001,051 bp from pter	End:	57,004,927 bp from pter
Size:	3,877 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APJ_HUMAN, P35414 (See protein sequence)

Recommended Name: Apelin receptor

Size: 380 amino acids; 42660 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

4 PDB 3D structures from and Proteopedia for APLNR:

2LOT (3D)

2LOU (3D)

2LOV (3D)

2LOW (3D)

Explore the universe of human proteins at neXtProt for APLNR: NX_P35414

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35414

APLNR Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005152.1

ENSEMBL proteins:

ENSP00000257254

Reactome Protein details: P35414
Human Recombinant Protein Products for APLNR:

	EMD Millipore Purified and/or Recombinant APLNR Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
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	GenScript Custom Purified and Recombinant Proteins Services for APLNR
	Novus Biologicals APLNR Protein Novus Biologicals APLNR Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for APLNR

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8294032
GO:0031410	cytoplasmic vesicle	--	--

APLNR for ontologies About GeneDecksing

APLNR Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of APLNR
	R&D Systems Antibodies for APLNR (APJ)
	OriGene Antibodies (see all 2): APLNR OriGene Custom Antibody Services for APLNR
	GenScript Custom Superior Antibodies Services for APLNR
	Novus Biologicals APLNR Antibodies
	Abcam antibodies for APLNR
	Uscn Antibodies for APLNR
	ThermoFisher Antibody for APLNR

Assay Products for APLNR:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript APLNR-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for APLNR

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

APLNR for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR003904 APJ_rcpt

IPR020279 Apelin_receptor_C

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P35414

ProtoNet protein and cluster: P35414

1 Blocks protein family: IPB003904 APJ receptor signature

UniProtKB/Swiss-Prot: APJ_HUMAN, P35414

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: APJ_HUMAN, P35414

Function: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor

with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	9792798
GO:0004930	G-protein coupled receptor activity	IEA	--

APLNR for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for APLNR:

Decreased substrate adherent c

Increased gamma-H2AX phosphory

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Aplnr):

behavior/neurological	cardiovascular system	embryogenesis	growth/size	homeostasis/metabolism
mortality/aging	muscle	renal/urinary system	reproductive system

APLNR for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for APLNR: Aplnr^tm1Dgen Aplnr^tm1.1Tq Aplnr^tm1Afu

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for APLNR

miRNA Products:		OriGene 3'-UTR Clone: APLNR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APLNR
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate APLNR (see all 15):
		hsa-miR-140-3p hsa-miR-676 hsa-miR-3655 hsa-miR-516b hsa-miR-3669 hsa-miR-4297 hsa-miR-128 hsa-miR-3681*

		SwitchGear 3'UTR luciferase reporter plasmid: APLNR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APLNR (see all 4) OriGene shRNA RFP: APLNR OriGene siRNA: APLNR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APLNR
		Sirion Biotech Custom design and validation of potent shRNA sequences against APLNR

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for APLNR
			Sirion Biotech Customized adenovirus for overexpression of APLNR Sirion Biotech Customized adenovirus for potent knockdown of APLNR

Clone Products:		EMD Millipore Clones for the Expression of APLNR
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APLNR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APLNR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APLNR (NM_005161)
		Sino Biological Human cDNA Clone for APLNR
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APLNR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APLNR

Cell Line Products:		GenScript APLNR-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for APLNR
		Sirion Biotech Customized stable knockdown cell line services for APLNR Sirion Biotech Customized inducible knockdown cell line services for APLNR Sirion Biotech Customized stable overexpressing cell line services for APLNR Sirion Biotech Customized inducible overexpressing cell line services for APLNR

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLNR

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	G alpha (i) signalling events	0.44
GPCR ligand binding	0.75	GPCRs, Class A Rhodopsin-like	0.41
Peptide ligand-binding receptors	0.61	Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Selected targets of GCR-alpha

Selected targets of GCR-alpha

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for APLNR

	Selected targets of GCR-alpha
	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1 BioSystems Pathway for APLNR

GPCRs, Class A Rhodopsin-like

5/7 Reactome Pathways for APLNR (see all 7)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Signal Transduction
	Signaling by GPCR
	G alpha (i) signalling events

1 Kegg Pathway (Kegg details for APLNR):

Neuroactive ligand-receptor interaction

APLNR for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for APLNR

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/143 Interacting proteins for APLNR (P35414³ ENSP00000257254⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 143)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APLN	Q9ULZ1³, ENSP00000305464⁴	I2D: score=1 STRING: ENSP00000305464
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126
ADORA1	ENSP00000308549⁴	STRING: ENSP00000308549
ADRA2A	ENSP00000280155⁴	STRING: ENSP00000280155
AGTR2	ENSP00000360973⁴	STRING: ENSP00000360973

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	TAS	9792798
GO:0050878	regulation of body fluid levels	IEA	--

APLNR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

APLNR for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for APLNR available from Tocris Bioscience About this table

Compound	Action	CAS #
Apelin-17 (human, bovine)	Endogenous APJ receptor agonist	[217082-57-0]

1 Novoseek chemical compound relationship for APLNR gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0	2	17638901 (1)

Search CenterWatch for drugs/clinical trials and news about APLNR / APJ

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APLNR gene:

NM_005161.4

Unigene Cluster for APLNR:

Apelin receptor

Hs.438311 [show with all ESTs]

Unigene Representative Sequence: NM_005161

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000257254(uc001njn.4)

miRNA Products:		OriGene 3'-UTR Clone: APLNR Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APLNR
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate APLNR (see all 15):
		hsa-miR-140-3p hsa-miR-676 hsa-miR-3655 hsa-miR-516b hsa-miR-3669 hsa-miR-4297 hsa-miR-128 hsa-miR-3681*

		SwitchGear 3'UTR luciferase reporter plasmid: APLNR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APLNR (see all 4) OriGene shRNA RFP: APLNR OriGene siRNA: APLNR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APLNR
		Sirion Biotech Custom design and validation of potent shRNA sequences against APLNR

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APLNR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APLNR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APLNR (NM_005161)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APLNR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APLNR

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APLNR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat APLNR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APLNR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APLNR

Additional cDNA sequence:

AK075252.1 AK097232.1 AK315542.1 NR_027991.1

9 DOTS entries:

DT.100779715 DT.100779716 DT.95372952 DT.95228165 DT.100779717 DT.120759815 DT.95083530 DT.95175961

DT.443799

24/148 AceView cDNA sequences (see all 148):

BU688257 NM_005161 BC032688 BG055737 AA195031 W57723 M79252 BU687507

BQ448027 CB153076 AW169607 BX387393 BQ712190 BI056575 BE672945 BX366307

AL599158 AK074514 BU070334 BU783635 N49977 CR605634 AK075252 AI953055

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APLNR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCGATGGAG

About this image

APLNR expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

S-shaped Body

Kidney Endothelial Cells

Endothelium

Ovary

Ovigerous Cord

Ovarian Somatic Cells

Ovary

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Skeletal Muscle

Kidney

Lumbar Vertebral Body

Somite

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10 LifeMap Cells

Name

Category

Bone marrow-derived mesenchymal stem cells (Stempeucel) (Adult Stem / Progenitor Cell)

Bone

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Primitive streak-like cells (Generation of endode...)

BMP4-induced embryoid bodies (Cardiac differentiat...)

Beating embryoid bodies (Cardiac differentiat...)

Mesoderm-like cells (Derivation of cardio...)

DKK1-induced cells (Derivation of cardio...)

See APLNR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APLNR

SOURCE GeneReport for Unigene cluster: Hs.438311

UniProtKB/Swiss-Prot: APJ_HUMAN, P35414

Tissue specificity: Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as

in the spleen, thymus, ovary, small intestine and colon

SABiosciences Expression via Pathway-Focused PCR Array including APLNR:

G Protein Coupled Receptors 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APLNR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat APLNR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APLNR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APLNR

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLNR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for APLNR gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	APLNR¹	apelin receptor	71.32(n) 65.92(a)		429337 XM_001232340.2 XP_001232341.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	67(a) 66(a)	1 ↔ many 1 ↔ many	1(92207955-92209076) AAWZ02038313(1247-2368)
African clawed frog (Xenopus laevis)	Amphibia	BC046659.1²	--	76.91(n)		BC046659.1
zebrafish (Danio rerio)	Actinopterygii	BC056308.1²	--	77.8(n)		BC056308.1

ENSEMBL Gene Tree for APLNR (if available)
TreeFam Gene Tree for APLNR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for APLNR gene

RXFP3² BDKRB1² AGTR2² AGTR1² GPR25² CXCR7² GPR15² BDKRB2²

RXFP4² GPR182²

18/34 SIMAP similar genes for APLNR using alignment to 1 protein entry: APJ_HUMAN(see all similar genes):

AGTR1 OPRK1 OPRL1 SSTR2 SSTR3 AGTR2

BDKRB2 CXCR7 GPR15 NPBWR1 SSTR1 SSTR5

CMKLR1 CCR5 GPR1 GPR17 gpcr CCBP2

APLNR for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143994415^1,2		--	57000555(+)	`CATCCA/GGAGCG`	2	--	ds500¹		0	--	--	--	--
rs147288003^1,2		--	57000678(+)	`GTAGAC/TGGATT`	2	--	ds500¹		0	--	--	--	--
rs138952733^1,2		--	57000844(+)	`CACTTA/TGCTGC`	2	--	ds500¹		0	--	--	--	--
rs184833688^1,2		--	57000898(+)	`CATCCC/TTTCCC`	2	--	ds500¹		0	--	--	--	--
rs3177149^1,2	C	--	57001135(-)	`GCCTTC/TTTCAG`	2	--	ut3¹ nc-transcript-variant		2		NA	4
rs76463472^1,2	C	--	57001305(+)	`CTTTGG/AGGACA`	2	--	ut3¹ nc-transcript-variant		1		WA	2
rs189300871^1,2		--	57001418(+)	`GCTGGC/TGTCAT`	2	--	ut3¹ int¹		0	--	--	--	--
rs144828425^1,2		--	57001419(+)	`CTGGCA/GTCATT`	2	--	int¹ ut3¹		0	--	--	--	--
rs148620821^1,2		--	57001527(+)	`AACCCA/GGAATA`	2	--	int¹ ut3¹		0	--	--	--	--
rs181557519^1,2		--	57001563(+)	`AGGCCC/TCACTA`	2	--	ut3¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for APLNR (57001051 - 57004927 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APLNR: --
Human Gene Mutation Database (HGMD): APLNR

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

APLNR for disorders           About GeneDecksing

OMIM gene information: 600052    OMIM disorders: --

19 diseases for APLNR:    About MalaCards

hypertension immunodeficiency proliferative diabetic retinopathy diabetic retinopathy

gestational diabetes dilated cardiomyopathy diabetes mellitus pulmonary hypertension

cardiomyopathy hermaphroditism liver disease dementia

breast carcinoma obesity hypoxia retinitis

carcinoma hepatitis neuronitis

5 Novoseek disease relationships for APLNR gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	50.6	14	11040134 (2), 9765485 (1), 12939143 (1), 12667811 (1) (see all 10)
heart failure	23.4	4	17266543 (1), 20178040 (1), 17826642 (1), 18272138 (1)
virus infection	0	3	10475064 (1), 11040134 (1)
hiv infections	0	2	20350050 (1), 10802050 (1)
tumors	0	2	20350050 (1), 18275845 (1)

Human Genome Epidemiology (HuGE) Navigator: APLNR (1 document)

Export disorders for APLNR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for APLNR gene, integrated from 9 sources (see all 121):
(articles sorted by number of sources associating them with APLNR)

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A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. (PubMed id 8294032)^{1, 2, 3, 9} O'Dowd B.F.... Nguyen T. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids. (PubMed id 14622440)^{1, 3} O'Carroll A.M....Lolait S.J. (2003)
Expression and coreceptor function of APJ for primate immunodeficiency viruses. (PubMed id 11040134)^{1, 9} Puffer B.A....Doms R.W. (2000)
Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ. (PubMed id 12667811)^{1, 9} Zhou N....Pomerantz R.J. (2003)
Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese. (PubMed id 19307984)^{1, 9} Li W.W....Zhu D.L. (2009)
Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway. (PubMed id 18401529)^{1, 9} Bai B....Song W. (2008)
Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. (PubMed id 14645236)^{1, 9} Lee D.K....O'Dowd B.F. (2004)
The fate of the internalized apelin receptor is deter mined by different isoforms of apelin mediating differential interaction with b eta-arrestin. (PubMed id 20353754)^{1, 9} Lee D.K....O'Dowd B.F. (2010)
Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. (PubMed id 17309882)^{1, 9} Hata J....Kubo M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 187	HGNC: 339	AceView: AGTRL1	Ensembl:ENSG00000134817	euGenes: HUgn187
ECgene: APLNR	Kegg: 187	H-InvDB: APLNR

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for APLNR	Pharmacogenomics, SNPs, Pathways

Intellectual Property for APLNR gene
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Patent Information for APLNR gene:
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