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Aliases for APLNR Gene

Aliases for APLNR Gene

  • Apelin Receptor 2 3 5
  • G-Protein Coupled Receptor HG11 3 4
  • Angiotensin II Receptor-Like 1 2 3
  • G-Protein Coupled Receptor APJ 3 4
  • Angiotensin Receptor-Like 1 3 4
  • APJ (Apelin) Receptor 2 3
  • AGTRL1 3 4
  • APJ 3 4
  • G Protein-Coupled Receptor APJ 3
  • HG11 Orphan Receptor 3
  • APJ Receptor 3
  • APJR 3
  • HG11 3

External Ids for APLNR Gene

Previous HGNC Symbols for APLNR Gene

  • AGTRL1

Previous GeneCards Identifiers for APLNR Gene

  • GC11M056758
  • GC11M057001
  • GC11M053349

Summaries for APLNR Gene

Entrez Gene Summary for APLNR Gene

  • This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]

GeneCards Summary for APLNR Gene

APLNR (Apelin Receptor) is a Protein Coding gene. Diseases associated with APLNR include Pulmonary Venoocclusive Disease and Hiv-1. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is ACKR3.

UniProtKB/Swiss-Prot for APLNR Gene

  • Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

Tocris Summary for APLNR Gene

  • Apelin-36, apelin-13 and [Pyr1]-apelin-13 are the predominant endogenous ligands for the apelin receptor (APJ) receptor. The APJ receptor and apelin peptides act as mediators of cardiovascular function, fluid homeostasis and adipocyte endocrine secretion.

Gene Wiki entry for APLNR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APLNR Gene

Genomics for APLNR Gene

Regulatory Elements for APLNR Gene

Enhancers for APLNR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APLNR on UCSC Golden Path with GeneCards custom track

Genomic Location for APLNR Gene

Chromosome:
11
Start:
57,233,577 bp from pter
End:
57,237,453 bp from pter
Size:
3,877 bases
Orientation:
Minus strand

Genomic View for APLNR Gene

Genes around APLNR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APLNR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APLNR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APLNR Gene

Proteins for APLNR Gene

  • Protein details for APLNR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35414-APJ_HUMAN
    Recommended name:
    Apelin receptor
    Protein Accession:
    P35414

    Protein attributes for APLNR Gene

    Size:
    380 amino acids
    Molecular mass:
    42660 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APLNR Gene

neXtProt entry for APLNR Gene

Proteomics data for APLNR Gene at MOPED

Post-translational modifications for APLNR Gene

  • Glycosylation at Asn 15 and Asn 175
  • Modification sites at PhosphoSitePlus

Other Protein References for APLNR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for APLNR Gene

Domains & Families for APLNR Gene

Gene Families for APLNR Gene

Protein Domains for APLNR Gene

Graphical View of Domain Structure for InterPro Entry

P35414

UniProtKB/Swiss-Prot:

APJ_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with APLNR: view

Function for APLNR Gene

Molecular function for APLNR Gene

UniProtKB/Swiss-Prot Function:
Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
genes like me logo Genes that share phenotypes with APLNR: view

Animal Models for APLNR Gene

MGI Knock Outs for APLNR:

Animal Model Products

CRISPR Products

miRNA for APLNR Gene

miRTarBase miRNAs that target APLNR

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APLNR Gene

Localization for APLNR Gene

Subcellular locations from UniProtKB/Swiss-Prot for APLNR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APLNR Gene COMPARTMENTS Subcellular localization image for APLNR gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for APLNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with APLNR: view

Pathways & Interactions for APLNR Gene

genes like me logo Genes that share pathways with APLNR: view

Pathways by source for APLNR Gene

Interacting Proteins for APLNR Gene

Gene Ontology (GO) - Biological Process for APLNR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007369 gastrulation IEA --
genes like me logo Genes that share ontologies with APLNR: view

No data available for SIGNOR curated interactions for APLNR Gene

Drugs & Compounds for APLNR Gene

(19) Drugs for APLNR Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>125</sup>I](Pyr<sup>1</sup>)apelin-13 Pharma Full agonist, Agonist 0
[<sup>125</sup>I][Glp<sup>65</sup>Nle<sup>75</sup>,Tyr<sup>77</sup>]apelin-13 Pharma Full agonist, Agonist 0
[<sup>125</sup>I][Nle<sup>75</sup>,Tyr<sup>77</sup>]apelin-36 (human) Pharma Full agonist, Agonist 0
[<sup>125</sup>I]apelin-13 Pharma Full agonist, Agonist 0
[<sup>3</sup>H](Pyr<sup>1</sup>)[Met(0)11]-apelin-13 Pharma Full agonist, Agonist 0

(5) Additional Compounds for APLNR Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Pyr1]-Apelin-13
217082-60-5
Apelin-17 (human, bovine)
217082-57-0
Apelin-36 (human)
252642-12-9
Apelin-36 (rat, mouse)
230299-95-3
ML 221
877636-42-5

(5) Tocris Compounds for APLNR Gene

Compound Action Cas Number
[Pyr1]-Apelin-13 Potent peptide agonist for APJ receptor 217082-60-5
Apelin-17 (human, bovine) Endogenous APJ receptor agonist 217082-57-0
Apelin-36 (human) Endogenous APJ receptor agonist 252642-12-9
Apelin-36 (rat, mouse) Endogenous APJ receptor agonist 230299-95-3
ML 221 Apelin receptor (APJ) antagonist 877636-42-5
genes like me logo Genes that share compounds with APLNR: view

Transcripts for APLNR Gene

mRNA/cDNA for APLNR Gene

Unigene Clusters for APLNR Gene

Apelin receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APLNR Gene

No ASD Table

Relevant External Links for APLNR Gene

GeneLoc Exon Structure for
APLNR
ECgene alternative splicing isoforms for
APLNR

Expression for APLNR Gene

mRNA expression in normal human tissues for APLNR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APLNR Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.4), Spleen (x5.3), and Brain - Hypothalamus (x5.0).

Protein differential expression in normal tissues from HIPED for APLNR Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APLNR Gene



SOURCE GeneReport for Unigene cluster for APLNR Gene Hs.438311

mRNA Expression by UniProt/SwissProt for APLNR Gene

P35414-APJ_HUMAN
Tissue specificity: Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.
genes like me logo Genes that share expression patterns with APLNR: view

Protein tissue co-expression partners for APLNR Gene

Primer Products

Orthologs for APLNR Gene

This gene was present in the common ancestor of chordates.

Orthologs for APLNR Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia APLNR 35
  • 90.79 (n)
  • 93.42 (a)
APLNR 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aplnr 35
  • 87.41 (n)
  • 92.55 (a)
Aplnr 16
Aplnr 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APLNR 35
  • 99.56 (n)
  • 99.74 (a)
APLNR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aplnr 35
  • 87.32 (n)
  • 90.43 (a)
cow
(Bos Taurus)
Mammalia APLNR 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APLNR 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves APLNR 35
  • 71.31 (n)
  • 65.74 (a)
APLNR 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii aplnra 36
  • 48 (a)
OneToMany
aplnra 36
  • 48 (a)
OneToMany
aplnrb 36
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for APLNR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APLNR Gene

ENSEMBL:
Gene Tree for APLNR (if available)
TreeFam:
Gene Tree for APLNR (if available)

Paralogs for APLNR Gene

Paralogs for APLNR Gene

genes like me logo Genes that share paralogs with APLNR: view

Variants for APLNR Gene

Sequence variations from dbSNP and Humsavar for APLNR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7943508 - 57,236,107(+) GTTGA(C/T)GTAGC nc-transcript-variant, reference, missense
rs746885 -- 57,234,558(+) TAGGG(A/G)GTGGA intron-variant, utr-variant-3-prime
rs746886 -- 57,234,637(+) AATGT(A/G)TGAAC intron-variant, utr-variant-3-prime
rs746887 -- 57,234,773(+) TCTCC(A/G)TCCCA intron-variant, utr-variant-3-prime
rs948846 -- 57,234,677(+) AGGAG(A/G)TTTGT intron-variant, utr-variant-3-prime

Variation tolerance for APLNR Gene

Residual Variation Intolerance Score: 16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APLNR Gene

Human Gene Mutation Database (HGMD)
APLNR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for APLNR Gene

Disorders for APLNR Gene

MalaCards: The human disease database

(2) MalaCards diseases for APLNR Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pulmonary venoocclusive disease
  • pulmonary veno-occlusive disease
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search APLNR in MalaCards View complete list of genes associated with diseases

Relevant External Links for APLNR

Genetic Association Database (GAD)
APLNR
Human Genome Epidemiology (HuGE) Navigator
APLNR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APLNR
genes like me logo Genes that share disorders with APLNR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APLNR Gene

Publications for APLNR Gene

  1. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. (PMID: 8294032) O'Dowd B.F. … Nguyen T. (Gene 1993) 2 3 4 23 67
  2. Plasma apelin levels and apelin/APJ mRNA expression in patients with gestational diabetes mellitus. (PMID: 19926159) Telejko B. … Gorska M. (Diabetes Res. Clin. Pract. 2010) 3 23
  3. Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatment? (PMID: 20055692) FalcALo-Pires I. … Leite-Moreira A. (Expert Opin. Ther. Targets 2010) 3 23
  4. The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin. (PMID: 20353754) Lee D.K. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2010) 3 23
  5. Structural insight into G-protein coupled receptor binding by apelin. (PMID: 19123778) Langelaan D.N. … Rainey J.K. (Biochemistry 2009) 3 23

Products for APLNR Gene

Sources for APLNR Gene

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