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APLNR Gene

protein-coding   GIFtS: 63
GCID: GC11M057001

Apelin Receptor

(Previous name: angiotensin II receptor-like 1)
(Previous symbol: AGTRL1)
  See APLNR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apelin Receptor1 2     G-Protein Coupled Receptor HG112 3
AGTRL11 2 3 5     APJR2
APJ2 3 5     HG112
Angiotensin II Receptor-Like 11 2     APJ Receptor2
APJ (Apelin) Receptor1 2     G Protein-Coupled Receptor APJ2
Angiotensin Receptor-Like 12 3     HG11 Orphan Receptor2
G-Protein Coupled Receptor APJ2 3     

External Ids:    HGNC: 3391   Entrez Gene: 1872   Ensembl: ENSG000001348177   OMIM: 6000525   UniProtKB: P354143   

Export aliases for APLNR gene to outside databases

Previous GC identifers: GC11M056758 GC11M053349


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APLNR Gene:
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the
angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a
counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It
functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor
angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from
alternative splicing have been identified. (provided by RefSeq, Jul 2009)

GeneCards Summary for APLNR Gene:
APLNR (apelin receptor) is a protein-coding gene. Diseases associated with APLNR include aortic valve stenosis, and hiv-1. GO annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is RXFP3.

UniProtKB/Swiss-Prot: APJ_HUMAN, P35414
Function: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in
various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also
plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for
APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS
dementia

summary for APLNR Gene:
Apelin-36, apelin-13 and [Pyr1]-apelin-13 are the predominant endogenous ligands for the apelin receptor
(APJ receptor), a G-protein-coupled receptor with considerable sequence homology to the angiotensin (AT1)
receptor. The APJ receptor and apelin peptides act as mediators of cardiovascular function, fluid
homeostasis and adipocyte endocrine secretion.

Gene Wiki entry for APLNR (Apelin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APLNR gene promoter:
         ISGF-3   RREB-1   GCNF   NF-AT   NF-AT4   NF-AT2   GCNF-1   NF-AT3   GCNF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPLNR promoter sequence
   Search Chromatin IP Primers for APLNR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APLNR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

APLNR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APLNR gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057001:  view genomic region     (about GC identifiers)

Start:
57,001,051 bp from pter      End:
57,004,927 bp from pter
Size:
3,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: APJ_HUMAN, P35414 (See protein sequence)
Recommended Name: Apelin receptor  
Size: 380 amino acids; 42660 Da
4 PDB 3D structures from and Proteopedia for APLNR:
2LOT (3D)        2LOU (3D)        2LOV (3D)        2LOW (3D)    

Explore the universe of human proteins at neXtProt for APLNR: NX_P35414

Explore proteomics data for APLNR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn15, Asn175
  • Modification sites at PhosphoSitePlus

  • See APLNR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005152.1  
    ENSEMBL proteins: 
     ENSP00000257254   ENSP00000475344  
    Reactome Protein details: P35414

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: apelin receptor
    Apelin receptor

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003904 APJ_rcpt
     IPR020279 Apelin_receptor_C
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P35414

    ProtoNet protein and cluster: P35414

    1 Blocks protein domain: IPB003904 APJ receptor signature

    UniProtKB/Swiss-Prot: APJ_HUMAN, P35414
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with APLNR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APJ_HUMAN, P35414
    Function: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in
    various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also
    plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for
    APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS
    dementia

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9792798
    GO:0004930G-protein coupled receptor activity IEA--
         
    Find genes that share ontologies with APLNR           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for APLNR:
     Decreased substrate adherent c  Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Aplnr):
     behavior/neurological  cardiovascular system  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle  renal/urinary system  reproductive system 

    Find genes that share phenotypes with APLNR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for APLNR: Aplnrtm1Dgen Aplnrtm1.1Tq Aplnrtm1Afu

       genOway: Develop your customized and physiologically relevant rodent model for APLNR

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    Selected qRT-PCR Assays for microRNAs that regulate APLNR (see all 15):
    hsa-miR-140-3p hsa-miR-676 hsa-miR-3655 hsa-miR-516b hsa-miR-3669 hsa-miR-4297 hsa-miR-128 hsa-miR-3681*
    SwitchGear 3'UTR luciferase reporter plasmidAPLNR 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APJ_HUMAN, P35414: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8294032
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with APLNR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APLNR About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    4Selected targets of GCR alpha
    Selected targets of GCR alpha


    Find genes that share SuperPaths with APLNR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for APLNR
        GPCRs, Class A Rhodopsin-like


    2 Reactome Pathways for APLNR
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for APLNR):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including APLNR: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for APLNR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for APLNR (P354143 ENSP000002572544) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLNQ9ULZ13, ENSP000003054644I2D: score=1 STRING: ENSP00000305464
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADORA1ENSP000003085494STRING: ENSP00000308549
    ADRA2AENSP000002801554STRING: ENSP00000280155
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9792798
    GO:0007369gastrulation IEA--
    GO:0007507heart development ISS--
    GO:0050878regulation of body fluid levels IEA--
    GO:0050909sensory perception of taste ----

    Find genes that share ontologies with APLNR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for APLNR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [Pyr1]-Apelin-13Potent peptide agonist for APJ receptor[217082-60-5]
    Apelin-36 (rat, mouse) Endogenous APJ receptor agonist[230299-95-3]
    Apelin-36 (human)Endogenous APJ receptor agonist[252642-12-9]
    Apelin-17 (human, bovine) Endogenous APJ receptor agonist[217082-57-0]
    ML 221Apelin receptor (APJ) antagonist[877636-42-5]

    Selected IUPHAR Ligands for APLNR (apelin receptor) (see all 17)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I][Nle75,Tyr77]apelin-36 (human)
    AgonistFull agonist11.211336787
    [125I][Glp65Nle75,Tyr77]apelin-13
    AgonistFull agonist10.710777510
    apelin-13
    AgonistFull agonist8.8 - 9.512603839 12939143 10777510
    [125I](Pyr1)apelin-13
    AgonistFull agonist9.511250876
    [125I]apelin-13
    AgonistFull agonist9.212939143
    apelin-17
    AgonistAgonist7.9 - 9.0212603839 15341513
    [Pyr1]apelin-13
    AgonistFull agonist7 - 8.812603839 11336787
    apelin-36
    AgonistFull agonist8.2 - 8.612603839 11336787 12939143 10777510
    [3H](Pyr1)[Met(0)11]-apelin-13
    AgonistFull agonist8.612603839
    MM54
    AntagonistAntagonist8.1521560248

    1 Novoseek inferred chemical compound relationship for APLNR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 2 17638901 (1)



    Find genes that share compounds with APLNR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APLNR gene: 
    NM_005161.4  

    Unigene Cluster for APLNR:

    Apelin receptor
    Hs.438311  [show with all ESTs]
    Unigene Representative Sequence: NM_005161
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257254(uc001njn.4) ENST00000606794
    miRNA
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    hsa-miR-140-3p hsa-miR-676 hsa-miR-3655 hsa-miR-516b hsa-miR-3669 hsa-miR-4297 hsa-miR-128 hsa-miR-3681*
    SwitchGear 3'UTR luciferase reporter plasmidAPLNR 3' UTR sequence
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    Additional mRNA sequence: 

    AK075252.1 AK097232.1 AK315542.1 NR_027991.1 

    9 DOTS entries:

    DT.100779715  DT.100779716  DT.95372952  DT.95228165  DT.100779717  DT.120759815  DT.95083530  DT.95175961 
    DT.443799 

    Selected AceView cDNA sequences (see all 148):

    BC032688 AK074514 CB153076 BX366307 BU070334 N49977 AL599158 BQ712190 
    BG055737 BU687507 AW169607 BE672945 BX387393 M79252 NM_005161 BU688257 
    CR605634 W57723 BU783635 BI056575 AA195031 BQ448027 BX382254 AK075252 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APLNR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGATGGAG
    APLNR Expression
    About this image


    APLNR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     NULL (Uncategorized)    fully expand to see all 4 entries
             Mesoderm-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
             Beating embryoid bodies
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    APLNR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APLNR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438311

    UniProtKB/Swiss-Prot: APJ_HUMAN, P35414
    Tissue specificity: Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well
    as in the spleen, thymus, ovary, small intestine and colon

        Pathway & Disease-focused RT2 Profiler PCR Array including APLNR: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLNR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for APLNR gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aplnr1 , 5 apelin receptor1, 5 87.41(n)1
    92.55(a)1
      2 (49.45 cM)5
    237961  NM_011784.31  NP_035914.11 
     851362255 
    chicken
    (Gallus gallus)
    Aves APLNR1 apelin receptor 71.31(n)
    65.74(a)
      429337  XM_001232340.3  XP_001232341.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    67(a)
    67(a)
    1 ↔ many
    1 ↔ many
    AAWZ02038313(1247-2368)
    1(92207955-92209076)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046659.12   -- 76.91(n)    BC046659.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056308.12   -- 77.8(n)    BC056308.1 


    ENSEMBL Gene Tree for APLNR (if available)
    TreeFam Gene Tree for APLNR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APLNR gene
    RXFP32  BDKRB12  AGTR22  GPR252  AGTR12  BDKRB22  ACKR32  GPR152  
    RXFP42  GPR1822  
    Selected SIMAP similar genes for APLNR using alignment to 1 protein entry:     APJ_HUMAN(see all similar genes):
    AGTR1    OPRK1    OPRL1    SSTR2    SSTR3    ACKR3
    AGTR2    BDKRB2    GPR15    NPBWR1    SSTR1    SSTR5
    CMKLR1    CCR5    GPR1    GPR17    gpcr    ACKR2

    Find genes that share paralogs with APLNR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APLNR (see all 206)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439944151,2
    C--57000555(+) CATCCA/GGAGCG 2 -- ds50010--------
    rs1472880031,2
    --57000678(+) GTAGAC/TGGATT 2 -- ds50010--------
    rs719779361,2
    C--57000686(+) TTGGT-/TGGA/ 
    TGGATGGA
    GGATG
    2 -- ds50010--------
    rs710580881,2
    C--57000726(+) TGGAT-/GGAT/ 
    GGATGGAT
    AGATG
    2 -- ds50011NA 2
    rs1389527331,2
    --57000844(+) CACTTA/TGCTGC 2 -- ds50010--------
    rs1848336881,2
    --57000898(+) CATCCC/TTTCCC 2 -- ds50010--------
    rs31771491,2
    C--57001135(-) GCCTTC/TTTCAG 2 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.00NA 4
    rs764634721,2
    C,F--57001305(+) CTTTGG/AGGACA 2 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.50WA 2
    rs1893008711,2
    --57001418(+) GCTGGC/TGTCAT 2 -- ut31 int10--------
    rs1448284251,2
    --57001419(+) CTGGCA/GTCATT 2 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for APLNR (57001051 - 57004927 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for APLNR: --
    Human Gene Mutation Database (HGMD): APLNR
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing APLNR
    DNA2.0 Custom Variant and Variant Library Synthesis for APLNR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600052    OMIM disorders: --

    2 diseases for APLNR:    
    About MalaCards
    aortic valve stenosis    hiv-1


    Find genes that share disorders with APLNR           About GenesLikeMe

    5 Novoseek inferred disease relationships for APLNR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 50.6 14 11040134 (2), 9765485 (1), 12939143 (1), 12667811 (1) (see all 10)
    heart failure 23.4 4 17266543 (1), 20178040 (1), 17826642 (1), 18272138 (1)
    virus infection 0 3 10475064 (1), 11040134 (1)
    hiv infections 0 2 20350050 (1), 10802050 (1)
    tumors 0 2 20350050 (1), 18275845 (1)

    Genetic Association Database (GAD): APLNR
    Human Genome Epidemiology (HuGE) Navigator: APLNR (1 document)

    Export disorders for APLNR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APLNR gene, integrated from 10 sources (see all 124):
    (articles sorted by number of sources associating them with APLNR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. (PubMed id 8294032)1, 2, 3, 9 O'Dowd B.F.... Nguyen T. (Gene 1993)
    2. Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese. (PubMed id 19307984)1, 4, 9 Li W.W....Zhu D.L. (J. Hypertens. 2009)
    3. Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations. (PubMed id 19680269)1, 4, 9 Hinohara K....Kimura A. (J. Hum. Genet. 2009)
    4. [Genetic risk factors of ischemic stroke identified by a genome-wide association study]. (PubMed id 19069168)1, 4 Kubo M. (Brain Nerve 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids. (PubMed id 14622440)1, 3 O'Carroll A.M....Lolait S.J. (J. Neuroendocrinol. 2003)
    7. Expression and coreceptor function of APJ for primate immunodeficiency viruses. (PubMed id 11040134)1, 9 Puffer B.A....Doms R.W. (Virology 2000)
    8. Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ. (PubMed id 12667811)1, 9 Zhou N....Pomerantz R.J. (Virology 2003)
    9. Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway. (PubMed id 18401529)1, 9 Bai B....Song W. (Acta Biochim. Biophys. Sin. (Shanghai) 2008)
    10. Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. (PubMed id 14645236)1, 9 Lee D.K....O'Dowd B.F. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 187 HGNC: 339 AceView: AGTRL1 Ensembl:ENSG00000134817 euGenes: HUgn187
    ECgene: APLNR Kegg: 187 H-InvDB: APLNR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APLNR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APLNR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APLNR gene:
    Search GeneIP for patents involving APLNR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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