Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APLN Gene

protein-coding   GIFtS: 52
GCID: GC0XM128779

Apelin

(Previous names: apelin, AGTRL1 ligand)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
apelin1 2
APEL2 3
APJ Endogenous Ligand2 3
Apelin, AGTRL1 Ligand1
XNPEP22
AGTRL1 Ligand2

External Ids:    HGNC: 166651   Entrez Gene: 88622   Ensembl: ENSG000001713887   OMIM: 3002975   UniProtKB: Q9ULZ13   

Export aliases for APLN gene to outside databases

Previous GC identifers: GC0XM126724 GC0XM127485 GC0XM128504 GC0XM128607 GC0XM118183


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APLN Gene:
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The
encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal
fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse
biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein
also functions as a coreceptor for the human immunodeficiency virus 1.(provided by RefSeq, Feb 2010)

GeneCards Summary for APLN Gene: 
APLN (apelin) is a protein-coding gene. Diseases associated with APLN include telangiectasis, and gestational diabetes, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include apelin receptor binding and receptor binding.

UniProtKB/Swiss-Prot: APEL_HUMAN, Q9ULZ1
Function: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry
in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other
synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation
of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by
influencing AVP release and drinking behavior

summary for APLN Gene:
Apelin-36, apelin-13 and [Pyr1]-apelin-13 are the predominant endogenous ligands for the apelin receptor
(APJ receptor), a G-protein-coupled receptor with considerable sequence homology to the angiotensin (AT1)
receptor. The APJ receptor and apelin peptides act as mediators of cardiovascular function, fluid
homeostasis and adipocyte endocrine secretion.

Gene Wiki entry for APLN (Apelin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APLN gene promoter:
         GR   c-Fos   oct-B3   oct-B2   AP-1   ATF-2   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPLN promoter sequence
   Search SABiosciences Chromatin IP Primers for APLN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq26.1   HGNC cytogenetic band: Xq25

APLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APLN gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM128779:  view genomic region     (about GC identifiers)

Start:
128,779,236 bp from pter      End:
128,788,933 bp from pter
Size:
9,698 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APEL_HUMAN, Q9ULZ1 (See protein sequence)
Recommended Name: Apelin precursor  
Size: 77 amino acids; 8569 Da
Subcellular location: Secreted
Sequence caution: Sequence=CAI95697.1; Type=Erroneous gene model prediction;
Secondary accessions: Q4VY08 Q8WU89

Explore the universe of human proteins at neXtProt for APLN: NX_Q9ULZ1

Post-translational modifications:

  • UniProtKB: Several active peptides may be produced by proteolytic processing of the peptide precursor
  • View neXtProt modification sites for NX_Q9ULZ1

  • APLN Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_059109.3  
    ENSEMBL proteins: 
     ENSP00000391800   ENSP00000390834   ENSP00000305464  
    Reactome Protein details: Q9ULZ1
    Human Recombinant Protein Products for APLN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for APLN
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for APLN
    GenScript Custom Purified and Recombinant Proteins Services for APLN
    Novus Biologicals APLN Proteins
    Novus Biologicals APLN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for APLN 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    APLN for ontologies           About GeneDecksing



    APLN Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for APLN
    GenScript Custom Superior Antibodies Services for APLN
    Novus Biologicals APLN Antibodies
    Abcam antibodies for APLN
    Cloud-Clone Corp. Antibodies for APLN 
    Search ThermoFisher Antibodies for APLN
    LSBio Antibodies in human, mouse, rat for APLN 

    Assay Products for APLN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for APLN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for APLN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for APLN 
    Cloud-Clone Corp. CLIAs for APLN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR026155 Apelin

    Graphical View of Domain Structure for InterPro Entry Q9ULZ1

    ProtoNet protein and cluster: Q9ULZ1

    UniProtKB/Swiss-Prot: APEL_HUMAN, Q9ULZ1
    Similarity: Belongs to the apelin family


    APLN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APEL_HUMAN, Q9ULZ1
    Function: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry
    in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other
    synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation
    of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by
    influencing AVP release and drinking behavior

         Summary:

    APLN as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Beating embryoid bodies from Heart, BMP4-induced embryoid bodies from Heart (see all).

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10525157
    GO:0005179hormone activity IEA--
    GO:0031704apelin receptor binding IEA--
         
    APLN for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Apln):
     behavior/neurological  cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism 
     muscle  vision/eye 

    APLN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for APLN: Aplntm1Ntak Aplntm1Pngr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for APLN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APLN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APLN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APLN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APLN
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate APLN (see all 59):
    hsa-miR-124* hsa-miR-142-5p hsa-miR-345 hsa-miR-15a hsa-miR-503 hsa-miR-1304 hsa-miR-424 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidAPLN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for APLN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APLN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for APLN
    Sirion Biotech Customized adenovirus for overexpression of APLN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for APLN (see all 7)
    OriGene ORF clones in mouse, rat for APLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: APLN (NM_005161)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APLN
    Sirion Biotech Customized lentivirus for stable overexpression of APLN 
                         Customized lentivirus expression plasmids for stable overexpression of APLN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for APLN
    Search LifeMap BioReagents cell lines for APLN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APLN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7        Reactome Pathways for APLN (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events



    APLN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/144 Interacting proteins for APLN (Q9ULZ13 ENSP000003054644) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLNRP354143, ENSP000002572544I2D: score=1 STRING: ENSP00000257254
    MDFIQ997503, ENSP000002303214I2D: score=1 STRING: ENSP00000230321
    CCR5ENSP000002923034STRING: ENSP00000292303
    GALENSP000002656434STRING: ENSP00000265643
    HEBP1ENSP000000149304STRING: ENSP00000014930
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002026regulation of the force of heart contraction IEA--
    GO:0006955immune response TAS10525157
    GO:0007165signal transduction IEA--
    GO:0007595lactation TAS10525157
    GO:0007631feeding behavior ----

    APLN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APLN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for APLN available from Tocris Bioscience    About this table
    CompoundAction CAS #
    [Pyr1]-Apelin-13Potent peptide agonist for APJ receptor[217082-60-5]
    Apelin-36 (rat, mouse) Endogenous APJ receptor agonist[230299-95-3]
    Apelin-36 (human)Endogenous APJ receptor agonist[252642-12-9]
    Apelin-17 (human, bovine) Endogenous APJ receptor agonist[217082-57-0]
    ML 221Apelin receptor (APJ) antagonist[877636-42-5]

    8 Novoseek inferred chemical compound relationships for APLN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 20.1 22 19756893 (5), 20346374 (3), 17177135 (3), 19643928 (2) (see all 9)
    ly294002 11.9 5 16563531 (1), 17136493 (1)
    matrigel 9.04 3 15530405 (1), 17129829 (1)
    nitric oxide 2.23 9 17628718 (2), 18772060 (2), 11384769 (1), 19344973 (1) (see all 5)
    cholesterol 0 2 17647139 (1), 16549903 (1)
    calcium 0 3 19100414 (1), 10871767 (1), 18082469 (1)
    phosphatidylinositol 0 1 15677759 (1)
    alanine 0 1 19100414 (1)

    Search CenterWatch for drugs/clinical trials and news about APLN / APEL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APLN gene: 
    NM_017413.4  

    Unigene Cluster for APLN:

    Apelin
    Hs.303084  [show with all ESTs]
    Unigene Representative Sequence: NM_017413
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429967 ENST00000427399 ENST00000307484(uc004eus.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APLN
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate APLN (see all 59):
    hsa-miR-124* hsa-miR-142-5p hsa-miR-345 hsa-miR-15a hsa-miR-503 hsa-miR-1304 hsa-miR-424 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidAPLN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for APLN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APLN
    Clone
    Products:
         
    OriGene clones in human, mouse for APLN (see all 7)
    OriGene ORF clones in mouse, rat for APLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: APLN (NM_005161)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APLN
    Sirion Biotech Customized lentivirus for stable overexpression of APLN 
                         Customized lentivirus expression plasmids for stable overexpression of APLN 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for APLN
    OriGene qSTAR qPCR primer pairs in human, mouse for APLN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APLN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APLN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APLN

    Additional mRNA sequence: 

    AB023493.1 AF086248.1 AK001855.1 AK312061.1 AY358657.1 BC021104.1 

    7 DOTS entries:

    DT.113501  DT.95157535  DT.121284804  DT.75148381  DT.100743542  DT.86852695  DT.91750146 

    24/81 AceView cDNA sequences (see all 81):

    BM992527 BC021104 AA367347 AA680168 AI419647 AF086248 BF939872 AW015212 
    W67638 BM741808 NM_017413 AA676726 AB023493 W94900 AY358657 BM975075 
    BQ024597 BM921930 AL544890 AI871137 AL544781 BF593250 W91937 BQ006616 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APLN expression in normal human tissues (normalized intensities)      APLN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAGGAGGG
    APLN Expression
    About this image


    APLN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 23 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             PureStem endothelial progenitor 30-SM2-1
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Granulosa Cells Primary Follicle
             Human Ovarian Microvascular Endothelial Cells (HOMEC)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             Human Brain Microvascular Endothelial Cells (HBMEC)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Normal Human Articular chondrocytes (NHAC)   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             PureStem endothelial Progenitor 30-SM2-3

    Genevestigator expression for APLN

    SOURCE GeneReport for Unigene cluster: Hs.303084

    UniProtKB/Swiss-Prot: APEL_HUMAN, Q9ULZ1
    Tissue specificity: Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and
    midbrain. Secreted by the mammary gland into the colostrum and the milk

        SABiosciences Custom PCR Arrays for APLN
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for APLN
    OriGene qSTAR qPCR primer pairs in human, mouse for APLN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APLN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APLN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APLN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for APLN gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apln1 , 5 apelin1, 5 82.25(n)1
    83.12(a)1
      X (25.48 cM)5
    308781  NM_013912.31  NP_038940.11 
     480251465 


    ENSEMBL Gene Tree for APLN (if available)
    TreeFam Gene Tree for APLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/157 SNPs in APLN are shown (see all 157)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915203991,2
    --128734357(+) GAGCCA/GCCGCT 1 -- ds50010--------
    rs1815159131,2
    --128734466(+) TTTCTC/TTCCTA 1 -- ds50010--------
    rs1862411481,2
    --128734505(+) TTTGTC/TTGAAG 1 -- ds50010--------
    rs1402718981,2
    --128734694(+) ACCCAA/GTGTTC 1 -- ds50010--------
    rs557709201,2
    C,F--128734738(+) ACAAAT/CGTGAA 1 -- ds50013Minor allele frequency- C:0.00WA NA 5
    rs1910910121,2
    --128734739(+) CAAACA/GTGAAG 1 -- ds50010--------
    rs1820697711,2
    --128734815(+) CATCAA/GGCAAC 1 -- ut310--------
    rs1877629361,2
    --128734864(+) TTATCA/TAATGT 1 -- ut310--------
    rs1910669741,2
    --128734865(+) TATCAA/CATGTA 1 -- ut310--------
    rs2010085141,2
    C--128735034(+) TGCTT-/AAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for APLN (128779236 - 128788933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for APLN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508800CNV Insertion20534489
    nsv528290CNV Gain19592680
    dgv2475e1CNV Complex17122850


    Locus Specific Mutation Databases (LSDB): APLN
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing APLN
    DNA2.0 Custom Variant and Variant Library Synthesis for APLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300297    OMIM disorders: --

    20/32 diseases for APLN (see all 32):    About MalaCards
    telangiectasis    gestational diabetes    morbid obesity    obesity, association with
    sleep apnea    fatty liver disease    proliferative diabetic retinopathy    diabetic retinopathy
    obesity    insulin resistance    dilated cardiomyopathy    sinusitis
    hypoxia    liver disease    acute myocardial infarction    atherosclerosis
    thromboembolism    hypercholesterolemia    myocardial infarction    aortic aneurysm


    APLN for disorders           About GeneDecksing

    10/18 Novoseek inferred disease relationships for APLN gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heart failure 50.8 31 20385929 (3), 19785937 (3), 18583184 (3), 17223209 (2) (see all 16)
    insulin resistance 49.6 14 20233941 (2), 17177135 (2), 16723381 (2), 20403579 (1) (see all 10)
    obesity 44.5 27 16723381 (4), 19756893 (3), 20233941 (2), 16733497 (2) (see all 13)
    cardiovascular diseases 35.3 9 19829178 (2), 17266543 (2), 12681234 (1), 17970534 (1) (see all 7)
    atherosclerosis 31 4 12193079 (1), 19940327 (1), 20178040 (1)
    immunodeficiency 30.5 4 12939143 (1), 10475064 (1), 11090199 (1)
    inflammation 29.1 13 19100414 (2), 19304942 (2), 19278844 (1), 18816630 (1) (see all 10)
    hyperinsulinemia 23.4 4 20233941 (1), 20045153 (1), 17647139 (1), 16733497 (1)
    cardiomyopathy 20.4 4 17204831 (2), 16549903 (1)
    coronary artery disease 18.9 4 20403579 (2), 19100414 (1), 16549903 (1)

    Genetic Association Database (GAD): APLN
    Human Genome Epidemiology (HuGE) Navigator: APLN (8 documents)

    Export disorders for APLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APLN gene, integrated from 9 sources (see all 228):
    (articles sorted by number of sources associating them with APLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. (PubMed id 10525157)1, 2, 3 Habata Y.... Fujino M. (1999)
    2. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. (PubMed id 9792798)1, 2, 3 Tatemoto K....Fujino M. (1998)
    3. Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese. (PubMed id 19307984)1, 4, 9 Li W.W....Zhu D.L. (2009)
    4. Association of apelin genetic variants with type 2 di abetes and related clinical features in Chinese Hans. (PubMed id 19567136)1, 4, 9 Zhang R....Jia W.P. (2009)
    5. Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry. (PubMed id 11090199)1, 2, 9 Cayabyab M.... Sodroski J. (2000)
    6. Characterization of apelin, the ligand for the APJ receptor. (PubMed id 10617103)1, 2, 9 Lee D.K.... O'Dowd B.F. (2000)
    7. The 212A variant of the APJ receptor gene for the endogenous inotrope apelin is associated with slower heart failure progression in idiopathic dilated cardiomyopathy. (PubMed id 17826642)1, 4, 9 Sarzani R....Rappelli A. (2007)
    8. Validation of genetic association in apelin-AGTRL1 sy stem with hypertension in a larger Han Chinese population. (PubMed id 20485192)1, 4 Niu W....Zhu D. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8862 HGNC: 16665 AceView: APLN Ensembl:ENSG00000171388 euGenes: HUgn8862
    ECgene: APLN H-InvDB: APLN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APLN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APLN gene:
    Search GeneIP for patents involving APLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Tocris Biochemicals & Compounds for APLN (Apelin)  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for APLN  
     OriGene qPCR primer pairs and template standards for APLN   OriGene Protein Over-expression Lysate for APLN  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for APLN  
     OriGene qSTAR qPCR primer pairs in human, mouse for APLN   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for APLN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for APLN   OriGene Custom Protein Services for APLN  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APLN
     QIAGEN SeqTarget long-range PCR primers for resequencing APLN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APLN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APLN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APLN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APLN
     GenScript Custom Purified and Recombinant Proteins Services for APLN GenScript cDNA clones with any tag delivered in your preferred vector for APLN
     GenScript Custom Assay Services for APLN GenScript Custom Superior Antibodies Services for APLN
     GenScript Custom overexpressing Cell Line Services for APLN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in APLN promoter
     Search Chromatin IP Primers for APLN
     RT2 qPCR Primer Assay in human, mouse, rat APLN
     GNC Network for APLN
     SABiosciences Custom PCR Arrays for APLN
     Tocris compounds for APLN
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     APLN antibodies
     APLN proteins
     APLN lysates
     Antibodies for APLN
     See all of Abcam's Antibodies, Kits and Proteins for APLN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for APLN
     Antibodies for APLN
     ELISAs for APLN
     CLIAs for APLN
     Search LifeMap BioReagents cell lines for APLN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLN
     SwitchGear 3'UTR luciferase reporter plasmids for APLN
     SwitchGear Promoter luciferase reporter plasmids for APLN
     Search ThermoFisher Antibodies for APLN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APLN
     inGenious Targeting Laboratory - Custom generated mouse model solutions for APLN
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APLN
    Customized:
     lentivirus for stable overexpression of APLN
     lentivirus expression plasmids for stable overexpression of APLN
     adenovirus for overexpression of APLN
     LSBio Antibodies in human, mouse, rat for APLN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      APLN gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4