APLF Gene
protein-coding GIFtS: 47
GCID: GC02P068694
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|
aprataxin and PNKP like factor(Previous name: chromosome 2 open reading frame 13 )
(Previous symbol: C2orf13)
| |
Aliases
for APLF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aprataxin And PNKP Like Factor1 2 | | MGC477991 | | C2orf131 2 3 5 | | Chromosome 2 Open Reading Frame 131 | | Xip11 2 | | Aprataxin And PNK-Like Factor2 | | Apurinic-Apyrimidinic Endonuclease APLF2 3 | | Aprataxin- And PNK-Like Factor2 | | PALF2 3 | | PNK And APTX-Like FHA Protein2 | | PNK And APTX-Like FHA Domain-Containing Protein2 3 | | EC 4.2.99.183 | | XRCC1-Interacting Protein 12 3 | | XIP13 | | APFL2 5 | | |
Export aliases for APLF gene to outside databasesPrevious GC identifers: GC02P068548 GC02P068431 |
Summaries
for APLF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for APLF:
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007(PubMed 17353262)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: APLF_HUMAN, Q8IW19Function: Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damagethrough interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently atsites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP)endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other typesof pyrimidine base damage
|
Genomic Views
for APLF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the APLF gene promoter:
E2F-4 E2F-3a E2F-5 Pax-5 HSF1 (long) E2F-2 AP-2gamma E2F E2F-1 HSF1short
Other transcription factors
Search SABiosciences Chromatin IP Primers for APLF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APLF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13.3 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p14APLF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P068694: view genomic region
(about GC identifiers)
Start:
|
68,694,691 bp from pter |
End:
|
68,858,004 bp from pter |
Size:
|
163,314 bases |
Orientation:
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plus strand |
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Proteins
for APLF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: APLF_HUMAN, Q8IW19 (See
protein sequence)Recommended Name: Aprataxin and PNK-like factor Size: 511 amino acids; 56956 Da
Subunit: Interacts with LIG4, PARP1, XRCC1, XRCC4 and XRCC5
Subcellular location: Nucleus. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strandbreaks and double-strand breaks via the PBZ-type zinc fingers
Sequence caution: Sequence=AAY14945.1; Type=Erroneous initiation;
5 PDB 3D structures from  and Proteopedia  for APLF:2KQB (3D)
2KQC (3D)
2KQD (3D)
2KQE (3D)
2KUO (3D)
Secondary accessions: A8K476 Q53P47 Q53PB9 Q53QU0Explore the universe of human proteins at neXtProt for APLF: NX_Q8IW19
Post-translational modifications:
Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc fingers, the proteinis also covalently poly-ADP-ribosylated by PARP11
Phosphorylated in an ATM-dependent manner upon double-strand DNA break1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IW19
APLF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775816.1
ENSEMBL proteins: ENSP00000307004 ENSP00000432297 ENSP00000393403
Human Recombinant Protein Products for APLF:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
APLF for ontologies About GeneDecksing
APLF Antibody Products:
Assay Products for APLF: |
Protein
Domains /
Families
for APLF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
APLF for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IW19ProtoNet protein and cluster: Q8IW19 UniProtKB/Swiss-Prot: APLF_HUMAN, Q8IW19Domain: The PBZ-type zinc fingers (also named CYR) mediate non-covalent poly(ADP-ribose)-binding.Poly(ADP-ribose)-binding is dependent on the presence of zinc and promotes its recruitment to DNA damage sitesDomain: The FHA-like domain mediates interaction with XRCC1 and XRCC4Similarity: Belongs to the APLF familySimilarity: Contains 1 FHA-like domainSimilarity: Contains 2 PBZ-type zinc fingers |
Function
for APLF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: APLF_HUMAN, Q8IW19Function: Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damagethrough interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently atsites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP)endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other typesof pyrimidine base damageCatalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-eliminationreaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate Enzyme Number (IUBMB): EC 4.2.99.181
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
APLF for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for APLF:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Aplf):
APLF for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APLF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APLF (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: APLF (NM_173545) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APLF | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APLF |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLF |
|
Pathways & Interactions
for APLF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APLF
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/19 Interacting proteins for APLF (Q8IW191, 2, 3 ENSP000003070044) via UniProtKB, MINT, STRING, and/or I2D (see all 19)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| XRCC5 | P130102, 3 | MINT-4790250 MINT-4790124 MINT-4790303 I2D:
score=2 | | PARP2 | Q9UGN52, 3, ENSP000002504164 | MINT-8201875 I2D:
score=1 STRING: ENSP00000250416 | | PARP1 | P098742, 3, ENSP000003557594 | MINT-4790102 MINT-4790124 MINT-4790085 I2D:
score=2 STRING: ENSP00000355759 | | XRCC1 | P188871, 2, 3, ENSP000002628874 | EBI-1256044,EBI-947466 MINT-4790124 I2D:
score=2 STRING: ENSP00000262887 | | XRCC4 | Q134262, 3, ENSP000003420114 | MINT-4790284 I2D:
score=3 STRING: ENSP00000342011 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
APLF for ontologies About GeneDecksing
|
Drugs & Compounds
for APLF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for APLF
Search CenterWatch for drugs/clinical trials and news about APLF
|
Transcripts
for APLF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for APLF gene: NM_173545.2 Unigene Cluster for APLF: Aprataxin and PNKP like factor Hs.720369 [show with all ESTs]Unigene Representative Sequence: NM_1735455 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000303795(uc010fdf.2 uc002sep.3) ENST00000529851(uc002ser.1)
ENST00000445692 ENST00000471727(uc002seq.1) ENST00000488585
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APLF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APLF (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: APLF (NM_173545) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APLF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APLF |
Additional cDNA sequence: AK290841.1 AK308186.1 BC030711.2 BC041144.1 5 DOTS entries: DT.40302033 DT.99938588 DT.110356 DT.101976854 DT.75120939 24/53 AceView cDNA sequences (see all 53): BQ226540 BX097685 AB084080 BQ342492 BC041144 AA677105 BG188837 NM_173545 NM_138964 AY089976 BQ342499 CD636589 BE936053 CD636591 H64244 AK122915 BX113242 BE464826 CD636587 R92039 AW418755 BX116921 BG719407 AI814997
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for APLF About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for APLF
|
Expression
for APLF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| APLF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAGCTGCTT
About this image
See APLF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APLF
SOURCE GeneReport for Unigene cluster: Hs.720369
SABiosciences Custom PCR Arrays for APLF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APLF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APLF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APLF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APLF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLF |
Orthologs
for APLF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for APLF gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for APLF (if available)
TreeFam Gene Tree for APLF (if available) |
Paralogs
for APLF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for APLF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for APLF (68694691 - 68858004 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for APLF
5 CNVs: 97876 97877 89709 89708 78585
1 Indel: 11176 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APLF |
|
Disorders
/ Diseases
for APLF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
APLF for disorders About GeneDecksing
OMIM gene information: 611035
OMIM disorders: --
5  diseases for APLF: About MalaCardsjunctional epidermolysis bullosa epidermolysis bullosa pleurisy thyroid cancer
thyroiditis
2 diseases from the University of Copenhagen DISEASES database for APLF:Degenerative disc disease Junctional epidermolysis bullosa Export disorders for APLF gene to outside databases
|
Publications
for APLF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for APLF gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with APLF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells. (PubMed id 18474613)1, 2, 3 Rulten S.L.... Caldecott K.W. (2008)
- APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. (PubMed id 18077224)1, 2, 3 Macrae C.J.... Koch C.A. (2008)
- APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. (PubMed id 17353262)1, 2, 3 Iles N.... Caldecott K.W. (2007)
- Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). (PubMed id 20098424)1, 2 Eustermann S....Neuhaus D. (2010)
- Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. (PubMed id 18172500)1, 2 Ahel I....West S.C. (2008)
- Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. (PubMed id 17507382)1, 2 Bekker-Jensen S.... Mailand N. (2007)
- A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. (PubMed id 17396150)1, 2 Kanno S....Yasui A. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
|
External Searches for APLF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing APLF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing APLF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing APLF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for APLF | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for APLF gene:
Search GeneIP for patents involving APLF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for APLF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for APLF | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APLF | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APLF | | | OriGene Protein Over-expression Lysate for APLF | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for APLF | | OriGene 3'-UTR Clone for APLF | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APLF | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APLF | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for APLF | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APLF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APLF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APLF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APLF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APLF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APLF |
| |
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| |  |  |  |  | | | | |
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 |
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 | | | APLF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APLF |
|  |  |  |  | | | | Search ThermoFisher Antibodies for APLF |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APLF |
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