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Aliases for APITD1-CORT Gene

Aliases for APITD1-CORT Gene

  • APITD1-CORT Readthrough 2 3 5

External Ids for APITD1-CORT Gene

Previous GeneCards Identifiers for APITD1-CORT Gene

  • GC01U903128
  • GC01P010491

Summaries for APITD1-CORT Gene

Entrez Gene Summary for APITD1-CORT Gene

  • This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for APITD1-CORT Gene

APITD1-CORT (APITD1-CORT Readthrough) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include protein heterodimerization activity and hormone activity. An important paralog of this gene is APITD1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APITD1-CORT Gene

Genomics for APITD1-CORT Gene

Regulatory Elements for APITD1-CORT Gene

Promoters for APITD1-CORT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APITD1-CORT on UCSC Golden Path with GeneCards custom track

Genomic Location for APITD1-CORT Gene

Chromosome:
1
Start:
10,430,102 bp from pter
End:
10,452,153 bp from pter
Size:
22,052 bases
Orientation:
Plus strand

Genomic View for APITD1-CORT Gene

Genes around APITD1-CORT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APITD1-CORT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APITD1-CORT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APITD1-CORT Gene

Proteins for APITD1-CORT Gene

  • Protein details for APITD1-CORT Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WT10
    Recommended name:
    Protein APITD1-CORT
    Protein Accession:
    A0A087WT10

    Protein attributes for APITD1-CORT Gene

    Size:
    143 amino acids
    Molecular mass:
    16498 Da
    Quaternary structure:
    No Data Available
  • Protein details for APITD1-CORT Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0U1RQL5
    Recommended name:
    Centromere protein S
    Protein Accession:
    A0A0U1RQL5

    Protein attributes for APITD1-CORT Gene

    Size:
    49 amino acids
    Molecular mass:
    5699 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APITD1-CORT Gene

Proteomics data for APITD1-CORT Gene at MOPED

Post-translational modifications for APITD1-CORT Gene

No Post-translational modifications

Other Protein References for APITD1-CORT Gene

No data available for DME Specific Peptides for APITD1-CORT Gene

Domains & Families for APITD1-CORT Gene

Protein Domains for APITD1-CORT Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APITD1-CORT: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for APITD1-CORT Gene

Function for APITD1-CORT Gene

Animal Model Products

miRNA for APITD1-CORT Gene

miRTarBase miRNAs that target APITD1-CORT

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APITD1-CORT Gene

Localization for APITD1-CORT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APITD1-CORT Gene COMPARTMENTS Subcellular localization image for APITD1-CORT gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for APITD1-CORT Gene

Pathways & Interactions for APITD1-CORT Gene

genes like me logo Genes that share pathways with APITD1-CORT: view

Pathways by source for APITD1-CORT Gene

1 KEGG pathway for APITD1-CORT Gene

Interacting Proteins for APITD1-CORT Gene

Gene Ontology (GO) - Biological Process for APITD1-CORT Gene

None

No data available for SIGNOR curated interactions for APITD1-CORT Gene

Drugs & Compounds for APITD1-CORT Gene

No Compound Related Data Available

Transcripts for APITD1-CORT Gene

mRNA/cDNA for APITD1-CORT Gene

(4) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for APITD1-CORT Gene

No ASD Table

Relevant External Links for APITD1-CORT Gene

GeneLoc Exon Structure for
APITD1-CORT
ECgene alternative splicing isoforms for
APITD1-CORT

Expression for APITD1-CORT Gene

mRNA expression in normal human tissues for APITD1-CORT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with APITD1-CORT: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for APITD1-CORT Gene

Orthologs for APITD1-CORT Gene

This gene was present in the common ancestor of chordates.

Orthologs for APITD1-CORT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APITD1 35
  • 88.11 (n)
  • 83.72 (a)
APITD1 36
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia APITD1 35
  • 86.5 (n)
  • 80.17 (a)
mouse
(Mus musculus)
Mammalia Apitd1 35
  • 81.2 (n)
  • 77.78 (a)
Apitd1 16
Apitd1 36
  • 54 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia APITD1 35
  • 99.52 (n)
  • 98.55 (a)
APITD1 36
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Apitd1 35
  • 81.94 (n)
  • 76.67 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves APITD1 35
  • 66.67 (n)
  • 66.67 (a)
APITD1 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia apitd1 35
  • 66.38 (n)
  • 69.23 (a)
zebrafish
(Danio rerio)
Actinopterygii apitd1 35
  • 63.31 (n)
  • 58.82 (a)
apitd1 36
  • 46 (a)
OneToMany
Species with no ortholog for APITD1-CORT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APITD1-CORT Gene

ENSEMBL:
Gene Tree for APITD1-CORT (if available)
TreeFam:
Gene Tree for APITD1-CORT (if available)

Paralogs for APITD1-CORT Gene

Paralogs for APITD1-CORT Gene

(1) SIMAP similar genes for APITD1-CORT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APITD1-CORT: view

Variants for APITD1-CORT Gene

Sequence variations from dbSNP and Humsavar for APITD1-CORT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1307487 -- 10,446,610(+) agact(A/G)taggt intron-variant
rs1307488 -- 10,447,053(+) AAACA(A/G)TCATT intron-variant
rs1307489 -- 10,447,179(+) GCTGC(A/G)ACACC intron-variant
rs2847340 -- 10,445,753(+) tgcag(G/T)ggcac intron-variant
rs4285702 -- 10,446,461(+) gcacc(C/T)ggcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APITD1-CORT Gene

Variant ID Type Subtype PubMed ID
dgv17e1 CNV Complex 17122850
essv3548 CNV CNV 17122850

Variation tolerance for APITD1-CORT Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APITD1-CORT Gene

HapMap Linkage Disequilibrium report
APITD1-CORT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APITD1-CORT Gene

Disorders for APITD1-CORT Gene

Relevant External Links for APITD1-CORT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APITD1-CORT

No disorders were found for APITD1-CORT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APITD1-CORT Gene

Publications for APITD1-CORT Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  2. A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours. (PMID: 15328517) Krona C. … Martinsson T. (Br. J. Cancer 2004) 3
  3. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for APITD1-CORT Gene

Sources for APITD1-CORT Gene

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