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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APIP Gene

protein-coding   GIFtS: 57
GCID: GC11M034861

APAF1 Interacting Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
APAF1 Interacting Protein1 2     MMRP192 5
Methylthioribulose-1-Phosphate Dehydratase1 2     APIP22
APAF1-Interacting Protein2 3     dJ179L10.22
hAPIP2 3     Probable Methylthioribulose-1-Phosphate Dehydratase2
MTRu-1-P Dehydratase2 3     EC 4.2.1.1093
CGI292 5     

External Ids:    HGNC: 175811   Entrez Gene: 510742   Ensembl: ENSG000001490897   OMIM: 6124915   UniProtKB: Q96GX93   

Export aliases for APIP gene to outside databases

Previous GC identifer: GC11M034602


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APIP Gene:
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury
(Cho et al., 2004 (PubMed 15262985)).(supplied by OMIM, Dec 2008)

GeneCards Summary for APIP Gene: 
APIP (APAF1 interacting protein) is a protein-coding gene. Diseases associated with APIP include non-small cell lung carcinoma, and cystic fibrosis, and among its related super-pathways are S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I and Metabolic pathways. GO annotations related to this gene include methylthioribulose 1-phosphate dehydratase activity and identical protein binding.

UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into
2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays
a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related
inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and
APAF1-mediated cell death

Gene Wiki entry for APIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APIP gene promoter:
         ER-alpha   CUTL1   Nkx2-5   E4BP4   Tal-1beta   RORalpha1   MEF-2A   Chx10   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPIP promoter sequence
   Search SABiosciences Chromatin IP Primers for APIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

APIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APIP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M034861:  view genomic region     (about GC identifiers)

Start:
34,874,641 bp from pter      End:
34,938,046 bp from pter
Size:
63,406 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9 (See protein sequence)
Recommended Name: Methylthioribulose-1-phosphate dehydratase  
Size: 242 amino acids; 27125 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with APAF1. May interact with CASP1
Subcellular location: Cytoplasm
Secondary accessions: A8K9D3 Q6PJX6 Q8WVU2 Q96HK2 Q9Y318
Alternative splicing: 2 isoforms:  Q96GX9-1   Q96GX9-3   

Explore the universe of human proteins at neXtProt for APIP: NX_Q96GX9

Explore proteomics data for APIP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GX9

  • APIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APIP Protein Expression
    REFSEQ proteins: NP_057041.2  
    ENSEMBL proteins: 
     ENSP00000474191   ENSP00000379133   ENSP00000278359  
    Reactome Protein details: Q96GX9
    Human Recombinant Protein Products for APIP: 
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    Novus Biologicals APIP Proteins
    Novus Biologicals APIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for APIP
    Cloud-Clone Corp. Proteins for APIP 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    APIP for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for APIP 

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    Cloud-Clone Corp. CLIAs for APIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR017714 MethylthioRu-1-P_deHdtase_MtnB
     IPR027514 Salvage_MtnB_euk
     IPR001303 Aldolase_II/adducin_N

    Graphical View of Domain Structure for InterPro Entry Q96GX9

    ProtoNet protein and cluster: Q96GX9

    UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
    Similarity: Belongs to the aldolase class II family. MtnB subfamily


    APIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTNB_HUMAN, Q96GX9
    Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into
    2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays
    a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related
    inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and
    APAF1-mediated cell death
    Catalytic activity: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O

         Enzyme Number (IUBMB): EC 4.2.1.1091

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
    GO:0042802identical protein binding IPI16189514
    GO:0046570methylthioribulose 1-phosphate dehydratase activity TAS--
    GO:0046872metal ion binding ----
         
    APIP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for APIP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APIP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APIP 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APIP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate APIP:
    hsa-miR-3163 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidAPIP 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of APIP 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APIP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APIP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Methionine salvage pathway
    Methionine salvage pathway0.67
    Metabolism of polyamines0.40
    S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I0.67
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Cysteine and methionine metabolism
    Cysteine and methionine metabolism0.37
    Sulfur amino acid metabolism0.37
    4Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for APIP
        S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I

    5        Reactome Pathways for APIP
        Metabolism of polyamines
    Metabolism
    Methionine salvage pathway
    Sulfur amino acid metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for APIP):
        Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6


    APIP for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/27 Interacting proteins for APIP (Q96GX91, 2, 3 ENSP000002783594) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67406 I2D: score=5 STRING: ENSP00000263925
    APIPQ96GX91, 2EBI-359248,EBI-359248 MINT-68172
    NUDT18Q6ZVK81, 2, 3, ENSP000003078524EBI-359248,EBI-740486 MINT-66886 I2D: score=5 STRING: ENSP00000307852
    VPS25Q9BRG12, 3, ENSP000002537944MINT-67303 I2D: score=5 STRING: ENSP00000253794
    TRAF1Q130772, 3, ENSP000003629944MINT-49518 I2D: score=2 STRING: ENSP00000362994
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS--
    GO:0006915apoptotic process IEA--
    GO:0019284L-methionine biosynthetic process from S-adenosylmethionine IEA--
    GO:0019509L-methionine salvage from methylthioadenosine TAS--

    APIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APIP (MTNB)

    Search CenterWatch for drugs/clinical trials and news about APIP / MTNB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APIP gene: 
    NM_015957.2  

    Unigene Cluster for APIP:

    APAF1 interacting protein
    Hs.447794  [show with all ESTs]
    Unigene Representative Sequence: AK226157
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532428 ENST00000395787(uc001mvs.2) ENST00000527830 ENST00000278359(uc010reo.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APIP
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate APIP:
    hsa-miR-3163 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidAPIP 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APIP
    Sirion Biotech Customized lentivirus for stable overexpression of APIP 
                         Customized lentivirus expression plasmids for stable overexpression of APIP 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APIP

    Additional mRNA sequence: 

    AF088034.1 AF131812.1 AF132963.1 AK225249.1 AK226157.1 AK292648.1 AK302225.1 BC008440.1 
    BC009077.1 BC017594.2 

    10 DOTS entries:

    DT.453541  DT.106256  DT.100766437  DT.454534  DT.100838225  DT.120698159  DT.92438933  DT.92438934 
    DT.95086812  DT.120698129 

    24/178 AceView cDNA sequences (see all 178):

    BM677228 CA392455 AI684307 BM263189 CR599175 CR621391 BM759020 AL559009 
    AF088034 AI309202 BF195141 CA427313 AL525537 W42832 BU182280 CR618871 
    CR598872 F10257 AA565240 AF131812 BU521864 F12642 BC009077 BX352317 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for APIP    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
    SP1:                    -           -                                             
    SP2:                    -     -     -                                             
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for APIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APIP expression in normal human tissues (normalized intensities)      APIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    APIP Expression
    About this image


    APIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   

    See APIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APIP

    SOURCE GeneReport for Unigene cluster: Hs.447794

    UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
    Tissue specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in
    heart, brain, pancreas, liver, placenta, skeletal muscle and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including APIP: 
              Amino Acid Metabolism I in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for APIP gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apip1 , 5 APAF1 interacting protein1, 5 87.69(n)1
    94.61(a)1
      2 (54.29 cM)5
    563691  NM_019735.41  NP_062709.31 
     1030736755 
    chicken
    (Gallus gallus)
    Aves APIP1 APAF1 interacting protein 80.51(n)
    87.95(a)
      428860  NM_001031547.1  NP_001026718.1 
    lizard
    (Anolis carolinensis)
    Reptilia APIP6
    APAF1 interacting protein
    81(a)
    1 ↔ 1
    GL343283.1(1767541-1791893)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69922 Xenopus laevis transcribed sequence with weak similarity more 75.82(n)    BU907032.1 
    zebrafish
    (Danio rerio)
    Actinopterygii apip1 APAF1 interacting protein 70.4(n)
    82.51(a)
      447941  NM_001004679.1  NP_001004679.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111341 CG11134 61.79(n)
    70.75(a)
      32334  NM_132688.3  NP_572916.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC373.51 Protein ZC373.5 51.27(n)
    44.16(a)
      181218  NM_077289.4  NP_509690.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDE1(YJR024C)4
    MDE11
    5'-methylthioribulose-1-phosphate dehydratase; acts more4
    Mde1p1
    55.45(n)1
    50.96(a)1
      10(470964-470230)4
    8534811, 4  NP_012558.31  NP_012558.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G538501 Enolase-phosphatase E1 58.25(n)
    57.07(a)
      835466  NM_203202.2  NP_974931.1 
    rice
    (Oryza sativa)
    Liliopsida Os.119372 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.25(n)    AK065321.1 


    ENSEMBL Gene Tree for APIP (if available)
    TreeFam Gene Tree for APIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APIP gene

    APIP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for APIP
    PGOHUM00000236751


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/768 SNPs in APIP are shown (see all 768)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0265754
    ----see VAR_0265752 R W mis40--------
    rs1921679981,2
    --34903352(+) GGCTAC/TTATTC 1 -- int10--------
    rs106522821,2
    C--34903409(+) CTTCT-/AAAAGTG 1 -- int10--------
    rs1466309781,2
    --34903483(+) ATGGCA/GGAGGG 1 -- int10--------
    rs1143338241,2
    F--34903504(+) AAGAAG/AAGCAT 1 -- int11Minor allele frequency- A:0.05WA 118
    rs29152251,2
    C,F,A,H--34903513(-) ttatcC/Ttttat 1 -- int117Minor allele frequency- T:0.20NS EA NA WA CSA 793
    rs1170781151,2
    C,F--34903586(+) ATGTGT/ATTGTC 1 -- int11Minor allele frequency- A:0.05EA 120
    rs1825843211,2
    --34903599(+) TGTAAC/TAAACC 1 -- int10--------
    rs64847461,2
    C,F,A,H--34903671(+) ATCATC/TGGTTT 1 -- int122Minor allele frequency- T:0.15NS EA NA CSA WA 2485
    rs1127588421,2
    C--34903876(+) TGACAC/TCAACA 1 -- ut311Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for APIP (34874641 - 34938046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for APIP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666133CNV Deletion23128226
    esv2673788CNV Deletion23128226
    esv34511CNV Loss17911159
    nsv832118CNV Gain17160897
    nsv8807CNV Gain18304495
    nsv832119CNV Gain17160897
    essv22260CNV CNV17122850
    essv21365CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612491    OMIM disorders: --

    2 diseases for APIP:    About MalaCards
    non-small cell lung carcinoma    cystic fibrosis


    APIP for disorders           About GeneDecksing

    Genetic Association Database (GAD): APIP
    Human Genome Epidemiology (HuGE) Navigator: APIP (1 document)

    Export disorders for APIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APIP gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with APIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf- 1-interacting protein. (PubMed id 15262985)1, 2, 3 Cho D.-H....Jung Y.-K. (2004)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway. (PubMed id 23285211)1, 2 Mary C....Lane L. (2012)
    4. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. (PubMed id 22837397)1, 2 Ko D.C.... Miller S.I. (2012)
    5. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Genome-wide association analysis of blood biomarkers i n chronic obstructive pulmonary disease. (PubMed id 23144326)1 Kim D.K....Silverman E.K. (2012)
    8. Crystallization and preliminary X-ray crystallographic analysis of human Apaf-1-interacting protein. (PubMed id 23192037)1 Kang W. and Yang J.K. (2012)
    9. Down-regulated expression of apoptosis-associated gene s APIP and UACA in non-small cell lung carcinoma. (PubMed id 22407486)1 Moravcikova E....Benkova K. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51074 HGNC: 17581 AceView: MMRP19 Ensembl:ENSG00000149089 euGenes: HUgn51074
    ECgene: APIP Kegg: 51074 H-InvDB: APIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APIP gene:
    Search GeneIP for patents involving APIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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