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APIP Gene

protein-coding   GIFtS: 57
GCID: GC11M034861

APAF1 Interacting Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
APAF1 Interacting Protein1 2     CGI292 5
Methylthioribulose-1-Phosphate Dehydratase1 2     MMRP192 5
APAF1-Interacting Protein2 3     APIP22
hAPIP2 3     Probable Methylthioribulose-1-Phosphate Dehydratase2
MTRu-1-P Dehydratase2 3     EC 4.2.1.1093

External Ids:    HGNC: 175811   Entrez Gene: 510742   Ensembl: ENSG000001490897   OMIM: 6124915   UniProtKB: Q96GX93   

Export aliases for APIP gene to outside databases

Previous GC identifer: GC11M034602


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APIP Gene:
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury
(Cho et al., 2004 (PubMed 15262985)).(supplied by OMIM, Dec 2008)

GeneCards Summary for APIP Gene:
APIP (APAF1 interacting protein) is a protein-coding gene. GO annotations related to this gene include methylthioribulose 1-phosphate dehydratase activity and identical protein binding.

UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into
2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays
a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related
inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and
APAF1-mediated cell death

Gene Wiki entry for APIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the APIP gene promoter:
         ER-alpha   CUTL1   Nkx2-5   E4BP4   Tal-1beta   RORalpha1   MEF-2A   Chx10   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPIP promoter sequence
   Search Chromatin IP Primers for APIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

APIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APIP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M034861:  view genomic region     (about GC identifiers)

Start:
34,874,641 bp from pter      End:
34,938,046 bp from pter
Size:
63,406 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9 (See protein sequence)
Recommended Name: Methylthioribulose-1-phosphate dehydratase  
Size: 242 amino acids; 27125 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with APAF1. May interact with CASP1
1 PDB 3D structure from and Proteopedia for APIP:
4M6R (3D)    
Secondary accessions: A8K9D3 Q6PJX6 Q8WVU2 Q96HK2 Q9Y318
Alternative splicing: 2 isoforms:  Q96GX9-1   Q96GX9-3   

Explore the universe of human proteins at neXtProt for APIP: NX_Q96GX9

Explore proteomics data for APIP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys33
  • Modification sites at PhosphoSitePlus

  • See APIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057041.2  
    ENSEMBL proteins: 
     ENSP00000474191   ENSP00000379133   ENSP00000278359  
    Reactome Protein details: Q96GX9

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    antibodies-online peptides for APIP

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017714 MethylthioRu-1-P_deHdtase_MtnB
     IPR027514 Salvage_MtnB_euk
     IPR001303 Aldolase_II/adducin_N

    Graphical View of Domain Structure for InterPro Entry Q96GX9

    ProtoNet protein and cluster: Q96GX9

    UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
    Similarity: Belongs to the aldolase class II family. MtnB subfamily


    Find genes that share domains with APIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTNB_HUMAN, Q96GX9
    Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into
    2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays
    a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related
    inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and
    APAF1-mediated cell death
    Catalytic activity: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O

         Enzyme Number (IUBMB): EC 4.2.1.1091

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
    GO:0042802identical protein binding IPI16189514
    GO:0046570methylthioribulose 1-phosphate dehydratase activity TAS--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with APIP           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for APIP

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate APIP:
    hsa-miR-3163 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidAPIP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTNB_HUMAN, Q96GX9: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with APIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APIP About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Methionine salvage pathway0.00
    Metabolism of polyamines0.00
    Metabolism of amino acids and derivatives
    S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    Cysteine and methionine metabolism0.35


    Find genes that share SuperPaths with APIP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for APIP
        S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I

    1 Reactome Pathway for APIP
        Methionine salvage pathway


    2 Kegg Pathways  (Kegg details for APIP):
        Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6

        Pathway & Disease-focused RT2 Profiler PCR Array including APIP: 

              Amino Acid Metabolism I in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for APIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for APIP (Q96GX91, 2, 3 ENSP000002783594) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67406 I2D: score=5 STRING: ENSP00000263925
    APIPQ96GX91, 2EBI-359248,EBI-359248 MINT-68172
    NUDT18Q6ZVK81, 2, 3, ENSP000003078524EBI-359248,EBI-740486 MINT-66886 I2D: score=5 STRING: ENSP00000307852
    VPS25Q9BRG12, 3, ENSP000002537944MINT-67303 I2D: score=5 STRING: ENSP00000253794
    TRAF1Q130772, 3, ENSP000003629944MINT-49518 I2D: score=2 STRING: ENSP00000362994
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS--
    GO:0006915apoptotic process IEA--
    GO:0019284L-methionine biosynthetic process from S-adenosylmethionine IEA--
    GO:0019509L-methionine salvage from methylthioadenosine TAS--

    Find genes that share ontologies with APIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APIP (MTNB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APIP gene: 
    NM_015957.3  

    Unigene Cluster for APIP:

    APAF1 interacting protein
    Hs.447794  [show with all ESTs]
    Unigene Representative Sequence: AK226157
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532428 ENST00000395787(uc001mvs.2) ENST00000527830 ENST00000278359(uc010reo.1)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate APIP:
    hsa-miR-3163 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidAPIP 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat APIP

    Additional mRNA sequence: 

    AF088034.1 AF131812.1 AF132963.1 AK225249.1 AK226157.1 AK292648.1 AK302225.1 BC008440.1 
    BC009077.1 BC017594.2 

    10 DOTS entries:

    DT.453541  DT.106256  DT.100766437  DT.454534  DT.100838225  DT.120698159  DT.92438933  DT.92438934 
    DT.95086812  DT.120698129 

    Selected AceView cDNA sequences (see all 178):

    BM759020 AF131812 BF195141 W42832 CR598872 CR621391 F10257 BC009077 
    AI684307 BU182280 BM263189 CA427313 BX352317 BM677228 CA392455 CR599175 
    AF088034 AL559009 F12642 CR618871 AI309202 AL525537 BU521864 AA565240 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for APIP    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
    SP1:                    -           -                                             
    SP2:                    -     -     -                                             
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for APIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    APIP Expression
    About this image


    APIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Heart (Cardiovascular System)
    APIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447794

    UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
    Tissue specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in
    heart, brain, pancreas, liver, placenta, skeletal muscle and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including APIP: 
              Amino Acid Metabolism I in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for APIP gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apip1 , 5 APAF1 interacting protein1, 5 87.69(n)1
    94.61(a)1
      2 (54.29 cM)5
    563691  NM_019735.41  NP_062709.31 
     1030736755 
    chicken
    (Gallus gallus)
    Aves APIP1 APAF1 interacting protein 80.51(n)
    87.95(a)
      428860  NM_001031547.1  NP_001026718.1 
    lizard
    (Anolis carolinensis)
    Reptilia APIP6
    APAF1 interacting protein
    81(a)
    1 ↔ 1
    GL343283.1(1767541-1791893)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69922 Xenopus laevis transcribed sequence with weak similarity more 75.82(n)    BU907032.1 
    zebrafish
    (Danio rerio)
    Actinopterygii apip1 APAF1 interacting protein 70.4(n)
    82.51(a)
      447941  NM_001004679.1  NP_001004679.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111341 CG11134 61.82(n)
    70.42(a)
      32334  NM_132688.4  NP_572916.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC373.51 ZC373.5 51.27(n)
    44.16(a)
      181218  NM_077289.4  NP_509690.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDE1(YJR024C)4
    MDE11
    5'-methylthioribulose-1-phosphate dehydratase; acts more4
    MDE11
    55.56(n)1
    50.72(a)1
      10(470964-470230)4
    8534811, 4  NP_012558.31  NP_012558.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G538501 AT5G53850 58.17(n)
    56.5(a)
      835466  NM_203202.2  NP_974931.1 
    rice
    (Oryza sativa)
    Liliopsida Os.119372 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.25(n)    AK065321.1 


    ENSEMBL Gene Tree for APIP (if available)
    TreeFam Gene Tree for APIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APIP gene

    Find genes that share paralogs with APIP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for APIP
    PGOHUM00000236751


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APIP (see all 768)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921679981,2
    --34903352(+) GGCTAC/TTATTC 1 -- int10--------
    rs106522821,2
    C--34903409(+) CTTCT-/AAAAGTG 1 -- int10--------
    rs1466309781,2
    --34903483(+) ATGGCA/GGAGGG 1 -- int10--------
    rs1143338241,2
    F--34903504(+) AAGAAG/AAGCAT 1 -- int11Minor allele frequency- A:0.05WA 118
    rs29152251,2
    C,F,A,H--34903513(-) ttatcC/Ttttat 1 -- int117Minor allele frequency- T:0.20NS EA NA WA CSA 793
    rs1170781151,2
    C,F--34903586(+) ATGTGT/ATTGTC 1 -- int11Minor allele frequency- A:0.05EA 120
    rs1825843211,2
    --34903599(+) TGTAAC/TAAACC 1 -- int10--------
    rs64847461,2
    C,F,A,H--34903671(+) ATCATC/TGGTTT 1 -- int122Minor allele frequency- T:0.15NS EA NA CSA WA 2485
    rs1127588421,2
    C--34903876(+) TGACAC/TCAACA 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1490402871,2
    --34904014(+) TTTGCC/TGTTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for APIP (34874641 - 34938046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for APIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666133CNV Deletion23128226
    esv2673788CNV Deletion23128226
    esv34511CNV Loss17911159
    nsv832118CNV Gain17160897
    nsv8807CNV Gain18304495
    nsv832119CNV Gain17160897
    essv22260CNV CNV17122850
    essv21365CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APIP
    DNA2.0 Custom Variant and Variant Library Synthesis for APIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612491    OMIM disorders: --


    Find genes that share disorders with APIP           About GenesLikeMe

    Genetic Association Database (GAD): APIP
    Human Genome Epidemiology (HuGE) Navigator: APIP (1 document)

    Export disorders for APIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APIP gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with APIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf- 1-interacting protein. (PubMed id 15262985)1, 2, 3 Cho D.-H....Jung Y.-K. (J. Biol. Chem. 2004)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway. (PubMed id 23285211)1, 2 Mary C....Lane L. (PLoS ONE 2012)
    4. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. (PubMed id 22837397)1, 2 Ko D.C.... Miller S.I. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. (PubMed id 24367089)1 Kang W....Yang J.K. (Proc. Natl. Acad. Sci. U.S.A. 2014)
    8. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. (PubMed id 23144326)1 Kim D.K....Silverman E.K. (Am. J. Respir. Crit. Care Med. 2012)
    9. Crystallization and preliminary X-ray crystallographic analysis of human Apaf-1-interacting protein. (PubMed id 23192037)1 Kang W. and Yang J.K. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012)
    10. Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma. (PubMed id 22407486)1 Moravcikova E....Benkova K. (Int. J. Oncol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51074 HGNC: 17581 AceView: MMRP19 Ensembl:ENSG00000149089 euGenes: HUgn51074
    ECgene: APIP Kegg: 51074 H-InvDB: APIP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for APIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for APIP gene:
    Search GeneIP for patents involving APIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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