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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APIP Gene

protein-coding   GIFtS: 53
GCID: GC11M034861

APAF1 interacting protein

 Explore 2 diseases affiliated with
APIP via our new
 Human Malady Compendium 
Biological research products
for APIP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
APAF1 Interacting Protein1 2     CGI-291
APIP21 2     Mmrp191
APAF1-Interacting Protein2 3     DJ179L10.21
MTRu-1-P Dehydratase2 3     Probable Methylthioribulose-1-Phosphate Dehydratase2
CGI292 5     EC 4.2.1.1093
MMRP192 5     HAPIP1

External Ids:    HGNC: 175811   Entrez Gene: 510742   Ensembl: ENSG000001490897   OMIM: 6124915   UniProtKB: Q96GX93   

Export aliases for APIP gene to outside databases

Previous GC identifer: GC11M034602


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APIP:
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et
al., 2004 (PubMed 15262985)).(supplied by OMIM, Dec 2008)

UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into
2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key
role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory
response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell
death

Gene Wiki entry for APIP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APIP gene promoter:
         ER-alpha   CUTL1   Nkx2-5   E4BP4   Tal-1beta   RORalpha1   MEF-2A   Chx10   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPIP promoter sequence
   Search SABiosciences Chromatin IP Primers for APIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

APIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APIP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M034861:  view genomic region     (about GC identifiers)

Start:
34,874,641 bp from pter      End:
34,938,046 bp from pter
Size:
63,406 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9 (See protein sequence)
Recommended Name: Methylthioribulose-1-phosphate dehydratase  
Size: 242 amino acids; 27125 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with APAF1. May interact with CASP1
Subcellular location: Cytoplasm
Secondary accessions: A8K9D3 Q6PJX6 Q8WVU2 Q96HK2 Q9Y318
Alternative splicing: 2 isoforms:  Q96GX9-1   Q96GX9-3   

Explore the universe of human proteins at neXtProt for APIP: NX_Q96GX9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96GX9

  • APIP Protein expression data from MOPED and PaxDb:    About this image 
    APIP Protein Expression
    REFSEQ proteins: NP_057041.2  
    ENSEMBL proteins: 
     ENSP00000379133   ENSP00000278359  
    Reactome Protein details: Q96GX9
    Human Recombinant Protein Products for APIP: 
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    Uscn Proteins for APIP

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    APIP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    APIP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR017714 MethylthioRu-1-P_deHdtase_MtnB
     IPR001303 Aldolase_II/adducin_N

    Graphical View of Domain Structure for InterPro Entry Q96GX9

    ProtoNet protein and cluster: Q96GX9

    UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
    Similarity: Belongs to the aldolase class II family. MtnB subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTNB_HUMAN, Q96GX9
    Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into
    2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key
    role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory
    response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell
    death
    Catalytic activity: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O

         Enzyme Number (IUBMB): EC 4.2.1.1091

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19060904
    GO:0042802identical protein binding IPI19060904
    GO:0046570methylthioribulose 1-phosphate dehydratase activity TAS--
    GO:0046872metal ion binding IEA--
         
    APIP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for APIP 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidAPIP 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Methionine salvage pathway
    Methionine salvage pathway1.00
    Metabolism of polyamines0.40
    S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation0.67
    2Sulfur amino acid metabolism
    Sulfur amino acid metabolism1.00
    Cysteine and methionine metabolism0.36
    3Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    4Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for APIP 
        S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation

    5        Reactome Pathways for APIP
        Metabolism of polyamines
    Metabolism
    Methionine salvage pathway
    Sulfur amino acid metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for APIP):
        Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6


    APIP for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/27 Interacting proteins for APIP (Q96GX91, 2, 3 ENSP000002783594) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67406 I2D: score=5 STRING: ENSP00000263925
    APIPQ96GX91, 2EBI-2848621,EBI-2848621 MINT-68172
    NUDT18Q6ZVK81, 2, 3, ENSP000003078524EBI-2848621,EBI-954151 MINT-66886 I2D: score=5 STRING: ENSP00000307852
    VPS25Q9BRG12, 3, ENSP000002537944MINT-67303 I2D: score=5 STRING: ENSP00000253794
    TRAF1Q130772, 3, ENSP000003629944MINT-49518 I2D: score=2 STRING: ENSP00000362994
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS--
    GO:0006915apoptotic process IEA--
    GO:0019509L-methionine salvage from methylthioadenosine TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    APIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APIP
    Search CenterWatch for drugs/clinical trials and news about APIP / MTNB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APIP gene: 
    NM_015957.2  

    Unigene Cluster for APIP:

    APAF1 interacting protein
    Hs.447794  [show with all ESTs]
    Unigene Representative Sequence: AK226157
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532428 ENST00000395787(uc001mvs.2) ENST00000527830 ENST00000278359(uc010reo.1)


    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate APIP:
    hsa-miR-3163 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidAPIP 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF088034.1 AF131812.1 AF132963.1 AK225249.1 AK226157.1 AK292648.1 AK302225.1 BC008440.1 
    BC009077.1 BC017594.2 

    10 DOTS entries:

    DT.453541  DT.106256  DT.100766437  DT.454534  DT.100838225  DT.120698159  DT.92438933  DT.92438934 
    DT.95086812  DT.120698129 

    24/178 AceView cDNA sequences (see all 178):

    CA392455 AI309202 BU182280 CR599175 BM263189 AI684307 F10257 W42832 
    CR618871 AL559009 BF195141 AF088034 CR598872 BM759020 CR621391 AL525537 
    CA427313 F12642 AA565240 BM677228 BX352317 BC009077 AF131812 BU521864 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for APIP    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
    SP1:                    -           -                                             
    SP2:                    -     -     -                                             
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for APIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    APIP Expression
    About this image
    See APIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APIP

    SOURCE GeneReport for Unigene cluster: Hs.447794

    UniProtKB/Swiss-Prot: MTNB_HUMAN, Q96GX9
    Tissue specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart,
    brain, pancreas, liver, placenta, skeletal muscle and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including APIP: 
              Amino Acid Metabolism I in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for APIP gene from 10/31 species (see all 31)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apip1 , 5 APAF1 interacting protein1, 5 87.69(n)1
    94.61(a)1
      2 (54.29 cM)5
    563691  NM_019735.41  NP_062709.31 
     1030736755 
    chicken
    (Gallus gallus)
    Aves APIP1 APAF1 interacting protein 80.51(n)
    87.95(a)
      428860  NM_001031547.1  NP_001026718.1 
    lizard
    (Anolis carolinensis)
    Reptilia APIP6
    --
    84(a)
    1 ↔ 1
    GL343283.1(1770168-1788383)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69922 Xenopus laevis transcribed sequence with weak similarity more 75.82(n)    BU907032.1 
    zebrafish
    (Danio rerio)
    Actinopterygii apip1 APAF1 interacting protein 70.4(n)
    82.51(a)
      447941  NM_001004679.1  NP_001004679.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111341 CG11134 61.79(n)
    70.75(a)
      32334  NM_132688.3  NP_572916.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC373.51 Protein ZC373.5 51.27(n)
    44.16(a)
      181218  NM_077289.4  NP_509690.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDE1(YJR024C)4
    MDE11
    5'-methylthioribulose-1-phosphate dehydratase; acts more4
    Mde1p1
    55.45(n)1
    50.96(a)1
      10(470964-470230)4
    8534811, 4  NP_012558.31  NP_012558.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G538501 Enolase-phosphatase E1 58.25(n)
    57.07(a)
      835466  NM_203202.2  NP_974931.1 
    rice
    (Oryza sativa)
    Liliopsida Os.119372 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.25(n)    AK065321.1 


    ENSEMBL Gene Tree for APIP (if available)
    TreeFam Gene Tree for APIP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APIP gene

    APIP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for APIP
    PGOHUM00000236751


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/688 NCBI SNPs in APIP are shown (see all 688    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007352971,2
    C--34615910(-) TCATTC/TANNNN 1 -- int10--------
    rs1921679981,2
    --34903352(+) GGCTAC/TTATTC 1 -- int10--------
    rs1413126251,2
    C--34903409(+) CTTCT-/AAAAGTG 1 -- int10--------
    rs1466309781,2
    --34903483(+) ATGGCA/GGAGGG 1 -- int10--------
    rs1143338241,2
    F--34903504(+) AAGAAG/AAGCAT 1 -- int11Minor allele frequency- A:0.05WA 118
    rs29152251,2
    C,F,A,H--34903513(-) TTATCC/TTTTAT 1 -- int117Minor allele frequency- T:0.20NS EA NA WA CSA 793
    rs1170781151,2
    C,F--34903586(+) ATGTGT/ATTGTC 1 -- int11Minor allele frequency- A:0.05EA 120
    rs1825843211,2
    --34903599(+) TGTAAC/TAAACC 1 -- int10--------
    rs64847461,2
    C,F,A,H--34903671(+) ATCATC/TGGTTT 1 -- int122Minor allele frequency- T:0.15NS EA NA CSA WA 2485
    rs1127588421,2
    C--34903876(+) TGACAC/TCAACA 1 -- ut311Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for APIP (34874641 - 34938046 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for APIP
         4 CNVs: 9181 30547 2917 85718

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    APIP for disorders           About GeneDecksing

    OMIM gene information: 612491    OMIM disorders: --

    2 diseases for APIP:    About MalaCards
    cystic fibrosis    fibrosis

    Human Genome Epidemiology (HuGE) Navigator: APIP (1 document)

    Export disorders for APIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APIP gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with APIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf- 1-interacting protein. (PubMed id 15262985)1, 2, 3 Cho D.-H....Jung Y.-K. (2004)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. (PubMed id 22837397)1, 2 Ko D.C.... Miller S.I. (2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway. (PubMed id 23285211)2 Mary C....Lane L. (2012)
    6. Down-regulated expression of apoptosis-associated gene s APIP and UACA in non-small cell lung carcinoma. (PubMed id 22407486)1 Moravcikova E....Benkova K. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. (PubMed id 21602797)1 Wright F.A....Cutting G.R. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51074 HGNC: 17581 AceView: MMRP19 Ensembl:ENSG00000149089 euGenes: HUgn51074
    ECgene: APIP Kegg: 51074 H-InvDB: APIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APIP gene:
    Search GeneIP for patents involving APIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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