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Aliases for APIP Gene

Aliases for APIP Gene

  • APAF1 Interacting Protein 2 3
  • Methylthioribulose-1-Phosphate Dehydratase 2 3
  • APAF1-Interacting Protein 3 4
  • MTRu-1-P Dehydratase 3 4
  • MMRP19 3 6
  • CGI29 3 6
  • HAPIP 3 4
  • Probable Methylthioribulose-1-Phosphate Dehydratase 3
  • EC 4.2.1.109 4
  • CGI-29 3
  • APIP2 3

External Ids for APIP Gene

Previous GeneCards Identifiers for APIP Gene

  • GC11M034602

Summaries for APIP Gene

Entrez Gene Summary for APIP Gene

  • APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]

GeneCards Summary for APIP Gene

APIP (APAF1 Interacting Protein) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include identical protein binding and methylthioribulose 1-phosphate dehydratase activity.

UniProtKB/Swiss-Prot for APIP Gene

  • Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.

Gene Wiki entry for APIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APIP Gene

Genomics for APIP Gene

Regulatory Elements for APIP Gene

Genomic Location for APIP Gene

Start:
34,853,094 bp from pter
End:
34,916,499 bp from pter
Size:
63,406 bases
Orientation:
Minus strand

Genomic View for APIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APIP Gene

Proteins for APIP Gene

  • Protein details for APIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GX9-MTNB_HUMAN
    Recommended name:
    Methylthioribulose-1-phosphate dehydratase
    Protein Accession:
    Q96GX9
    Secondary Accessions:
    • A8K9D3
    • Q6PJX6
    • Q8WVU2
    • Q96HK2
    • Q9Y318

    Protein attributes for APIP Gene

    Size:
    242 amino acids
    Molecular mass:
    27125 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with APAF1. May interact with CASP1.

    Three dimensional structures from OCA and Proteopedia for APIP Gene

    Alternative splice isoforms for APIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APIP Gene

Proteomics data for APIP Gene at MOPED

Post-translational modifications for APIP Gene

  • Ubiquitination at Lys33
  • Modification sites at PhosphoSitePlus

Other Protein References for APIP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for APIP Gene

Domains for APIP Gene

Protein Domains for APIP Gene

Suggested Antigen Peptide Sequences for APIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GX9

UniProtKB/Swiss-Prot:

MTNB_HUMAN :
  • Q96GX9
Family:
  • Belongs to the aldolase class II family. MtnB subfamily.
genes like me logo Genes that share domains with APIP: view

No data available for Gene Families for APIP Gene

Function for APIP Gene

Molecular function for APIP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.

Enzyme Numbers (IUBMB) for APIP Gene

Gene Ontology (GO) - Molecular Function for APIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0042802 identical protein binding IPI 16189514
GO:0046570 methylthioribulose 1-phosphate dehydratase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with APIP: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APIP

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APIP Gene

Localization for APIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for APIP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APIP Gene COMPARTMENTS Subcellular localization image for APIP gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for APIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol --
genes like me logo Genes that share ontologies with APIP: view

Pathways for APIP Gene

genes like me logo Genes that share pathways with APIP: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q96GX9-MTNB_HUMAN

  • Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.

Gene Ontology (GO) - Biological Process for APIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process TAS --
GO:0006915 apoptotic process IEA --
GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine IEA --
GO:0019509 L-methionine biosynthetic process from methylthioadenosine TAS --
genes like me logo Genes that share ontologies with APIP: view

Transcripts for APIP Gene

Unigene Clusters for APIP Gene

APAF1 interacting protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APIP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APIP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for APIP Gene

GeneLoc Exon Structure for
APIP
ECgene alternative splicing isoforms for
APIP

Expression for APIP Gene

mRNA expression in normal human tissues for APIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for APIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3) and Salivary gland (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APIP Gene

SOURCE GeneReport for Unigene cluster for APIP Gene Hs.447794

mRNA Expression by UniProt/SwissProt for APIP Gene

Q96GX9-MTNB_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.
genes like me logo Genes that share expressions with APIP: view

Expression partners for APIP Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for APIP Gene

Orthologs for APIP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for APIP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APIP 35
  • 88.84 (n)
  • 91.32 (a)
APIP 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APIP 35
  • 92.59 (n)
  • 95.77 (a)
APIP 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apip 35
  • 87.69 (n)
  • 94.61 (a)
Apip 16
Apip 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APIP 35
  • 99.45 (n)
  • 100 (a)
APIP 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APIP 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves APIP 35
  • 80.51 (n)
  • 87.95 (a)
APIP 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APIP 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apip 35
  • 72.39 (n)
  • 82.4 (a)
Str.1776 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6992 35
zebrafish
(Danio rerio)
Actinopterygii apip 35
  • 70.4 (n)
  • 82.51 (a)
apip 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9020 35
African malaria mosquito
(Anopheles gambiae)
Insecta MTNB_ANOGA 35
  • 60.93 (n)
  • 67.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11134 35
  • 61.82 (n)
  • 70.42 (a)
CG11134 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZC373.5 35
  • 51.27 (n)
  • 44.16 (a)
ZC373.5 36
  • 34 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL126W 35
  • 50.77 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDE1 35
  • 55.56 (n)
  • 50.72 (a)
MDE1 36
  • 43 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G53850 35
  • 58.17 (n)
  • 56.5 (a)
soybean
(Glycine max)
eudicotyledons Gma.4561 35
rice
(Oryza sativa)
Liliopsida Os.11937 35
Os11g0484000 35
  • 60.33 (n)
  • 57 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14582 35
corn
(Zea mays)
Liliopsida Zm.2643 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9700 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09264 35
  • 55.92 (n)
  • 54.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC20H4.05c 35
  • 52.43 (n)
  • 45.07 (a)
Species with no ortholog for APIP:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for APIP Gene

ENSEMBL:
Gene Tree for APIP (if available)
TreeFam:
Gene Tree for APIP (if available)

Paralogs for APIP Gene

Pseudogenes.org Pseudogenes for APIP Gene

genes like me logo Genes that share paralogs with APIP: view

No data available for Paralogs for APIP Gene

Variants for APIP Gene

Sequence variations from dbSNP and Humsavar for APIP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs140839 -- 34,895,757(+) CAGAC(-/AGAT)CAGAT intron-variant
rs891546 -- 34,910,482(-) TGTCT(C/T)CTCAT intron-variant
rs984690 -- 34,914,114(-) ggaaa(A/C)agtga intron-variant
rs1117050 -- 34,904,791(-) ataat(A/G)tatcc intron-variant
rs1117051 -- 34,904,546(-) tctaa(C/T)agaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APIP Gene

Variant ID Type Subtype PubMed ID
nsv832118 CNV Gain 17160897
nsv832119 CNV Gain 17160897
nsv8807 CNV Gain 18304495
essv21365 CNV CNV 17122850
esv2666133 CNV Deletion 23128226
esv34511 CNV Loss 17911159
essv22260 CNV CNV 17122850
esv2673788 CNV Deletion 23128226

Relevant External Links for APIP Gene

HapMap Linkage Disequilibrium report
APIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APIP Gene

Disorders for APIP Gene

Relevant External Links for APIP

Genetic Association Database (GAD)
APIP
Human Genome Epidemiology (HuGE) Navigator
APIP

No disorders were found for APIP Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for APIP Gene

Publications for APIP Gene

  1. Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf- 1-interacting protein. (PMID: 15262985) Cho D.-H. … Jung Y.-K. (J. Biol. Chem. 2004) 2 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. (PMID: 22837397) Ko D.C. … Miller S.I. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48

Products for APIP Gene

Sources for APIP Gene

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