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Aliases for API5 Gene

Aliases for API5 Gene

  • Apoptosis Inhibitor 5 2 3 5
  • Fibroblast Growth Factor 2-Interacting Factor 2 2 3
  • Cell Migration-Inducing Gene 8 Protein 3 4
  • Migration-Inducing Protein MIG8 2 3
  • Antiapoptosis Clone 11 Protein 3 4
  • AAC-11 3 4
  • FIF 3 4
  • Fibroblast Growth Factor 2-Interacting Factor 4
  • Protein XAGL 4
  • API5-Like 1 2
  • AAC11 3
  • API-5 4

External Ids for API5 Gene

Previous GeneCards Identifiers for API5 Gene

  • GC11M045153
  • GC11P044016
  • GC11P043372
  • GC11P043297
  • GC11P043290
  • GC11P043043

Summaries for API5 Gene

Entrez Gene Summary for API5 Gene

  • This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for API5 Gene

API5 (Apoptosis Inhibitor 5) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and fibroblast growth factor binding.

UniProtKB/Swiss-Prot for API5 Gene

  • Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Gene Wiki entry for API5 Gene

Additional gene information for API5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for API5 Gene

Genomics for API5 Gene

Regulatory Elements for API5 Gene

Enhancers for API5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H043904 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.7 +593.9 593913 2 RFX1 POLR2A GATA2 RBAK JUN TSC22D4 RCOR1 ZNF24 NR2F2 ALKBH3 LOC105376644 PPIAP41 API5 TTC17 SEC14L1P1 ALKBH3-AS1
GH11H043738 1.4 FANTOM5 Ensembl ENCODE 10.3 +427.4 427416 1 HDAC1 ATF1 FEZF1 ZNF366 CREM CEBPB ZEB2 ZNF843 ZNF592 ZNF217 HSD17B12 ALKBH3 PPIAP41 SEC14L1P1 ALKBH3-AS1 API5 RN7SKP287 EXT2 ENSG00000254409 TTC17
GH11H043357 1.1 ENCODE 6.5 +47.5 47461 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 SP3 TTC17 SEC14L1P1 ALKBH3 ACCS EXT2 API5 ENSG00000254907 ENSG00000255340
GH11H043311 1.1 ENCODE 6.3 +0.6 584 2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 ZNF143 ENSG00000254907 SEC14L1P1 TTC17 ALKBH3 LOC105376644 ENSG00000255165 RN7SKP287 ACCS EXT2 API5
GH11H043366 1 Ensembl ENCODE 4.9 +55.3 55303 1 ATF1 TAL1 FOSL1 TCF12 ZNF316 FOXK2 NCOR1 FOS TRIM24 NFE2 ENSG00000254577 API5 ENSG00000254907 ENSG00000255340
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around API5 on UCSC Golden Path with GeneCards custom track

Promoters for API5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039176 446 2000 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 ZNF143

Genomic Location for API5 Gene

Chromosome:
11
Start:
43,311,955 bp from pter
End:
43,344,530 bp from pter
Size:
32,576 bases
Orientation:
Plus strand

Genomic View for API5 Gene

Genes around API5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
API5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for API5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for API5 Gene

Proteins for API5 Gene

  • Protein details for API5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZZ5-API5_HUMAN
    Recommended name:
    Apoptosis inhibitor 5
    Protein Accession:
    Q9BZZ5
    Secondary Accessions:
    • B4DGR0
    • B4DRJ2
    • B4E283
    • D3DR21
    • O15441
    • Q9Y4J7

    Protein attributes for API5 Gene

    Size:
    524 amino acids
    Molecular mass:
    59005 Da
    Quaternary structure:
    • Monomer. Interacts with FGF2 and ACIN1.
    SequenceCaution:
    • Sequence=AAB86528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB86528.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for API5 Gene

    Alternative splice isoforms for API5 Gene

neXtProt entry for API5 Gene

Post-translational modifications for API5 Gene

  • Acetylation at Lys-251 impairs antiapoptotic function.
  • Ubiquitination at Lys12, Lys51, and posLast=487487
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for API5 Gene

Domains & Families for API5 Gene

Gene Families for API5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for API5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZZ5

UniProtKB/Swiss-Prot:

API5_HUMAN :
  • Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.
  • Belongs to the API5 family.
Domain:
  • Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.
Family:
  • Belongs to the API5 family.
genes like me logo Genes that share domains with API5: view

Function for API5 Gene

Molecular function for API5 Gene

GENATLAS Biochemistry:
antiapoptosis 5,inhibiting apoptosis after growth factor withdrawal,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Phenotypes From GWAS Catalog for API5 Gene

Gene Ontology (GO) - Molecular Function for API5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 19387494
GO:0017134 fibroblast growth factor binding IPI 11075807
genes like me logo Genes that share ontologies with API5: view
genes like me logo Genes that share phenotypes with API5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for API5
  • Applied Biological Materials Clones for API5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for API5 Gene

Localization for API5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for API5 Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for API5 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for API5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11075807
GO:0005681 spliceosomal complex ISS 11555636
GO:0005737 cytoplasm NAS 11075807
GO:0016020 membrane IDA 19946888
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with API5: view

Pathways & Interactions for API5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for API5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process TAS,NAS 10780674
GO:2000270 negative regulation of fibroblast apoptotic process IEA --
genes like me logo Genes that share ontologies with API5: view

No data available for Pathways by source and SIGNOR curated interactions for API5 Gene

Drugs & Compounds for API5 Gene

No Compound Related Data Available

Transcripts for API5 Gene

Unigene Clusters for API5 Gene

Apoptosis inhibitor 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for API5
  • Applied Biological Materials Clones for API5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for API5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for API5 Gene

GeneLoc Exon Structure for
API5
ECgene alternative splicing isoforms for
API5

Expression for API5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for API5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for API5 Gene

This gene is overexpressed in Lymph node (10.3) and Peripheral blood mononuclear cells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for API5 Gene



Protein tissue co-expression partners for API5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of API5 Gene:

API5

SOURCE GeneReport for Unigene cluster for API5 Gene:

Hs.435771

mRNA Expression by UniProt/SwissProt for API5 Gene:

Q9BZZ5-API5_HUMAN
Tissue specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.

Evidence on tissue expression from TISSUES for API5 Gene

  • Nervous system(5)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with API5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for API5 Gene

Orthologs for API5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for API5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia API5 33 34
  • 99.87 (n)
oppossum
(Monodelphis domestica)
Mammalia API5 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia API5 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia API5 33 34
  • 93.64 (n)
cow
(Bos Taurus)
Mammalia API5 33 34
  • 93.39 (n)
rat
(Rattus norvegicus)
Mammalia Api5 33
  • 90.51 (n)
mouse
(Mus musculus)
Mammalia Api5 33 16 34
  • 89.85 (n)
chicken
(Gallus gallus)
Aves API5 33 34
  • 81.63 (n)
lizard
(Anolis carolinensis)
Reptilia API5 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia api5 33
  • 74.42 (n)
Str.5903 33
African clawed frog
(Xenopus laevis)
Amphibia srnyz021-prov 33
zebrafish
(Danio rerio)
Actinopterygii api5 33 34
  • 73.05 (n)
srnyz021 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6581 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009645 33
  • 53.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta Aac11 35 33 34
  • 52.82 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29030 33
  • 49.13 (n)
rice
(Oryza sativa)
Liliopsida Os02g0313400 33
  • 43.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToOne
Species where no ortholog for API5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for API5 Gene

ENSEMBL:
Gene Tree for API5 (if available)
TreeFam:
Gene Tree for API5 (if available)

Paralogs for API5 Gene

Pseudogenes.org Pseudogenes for API5 Gene

genes like me logo Genes that share paralogs with API5: view

No data available for Paralogs for API5 Gene

Variants for API5 Gene

Sequence variations from dbSNP and Humsavar for API5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000011936 -- 43,328,427(+) CCCTA(A/C)CTCTC intron-variant
rs1000082828 -- 43,335,794(+) TTATA(A/C)ATGTA intron-variant
rs1000111116 -- 43,316,219(+) AGCCC(C/T)AGTTT intron-variant
rs1000154251 -- 43,328,297(+) ATGGA(C/T)TTACG intron-variant
rs1000291477 -- 43,335,987(+) AACTT(G/T)AATTA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for API5 Gene

Variant ID Type Subtype PubMed ID
esv3306211 CNV mobile element insertion 20981092
esv3355802 CNV insertion 20981092
nsv1145518 CNV deletion 24896259
nsv554119 CNV gain 21841781
nsv972004 CNV duplication 23825009

Variation tolerance for API5 Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for API5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
API5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for API5 Gene

Disorders for API5 Gene

Relevant External Links for API5

Genetic Association Database (GAD)
API5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
API5

No disorders were found for API5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for API5 Gene

Publications for API5 Gene

  1. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. (PMID: 9307294) Tewari M … Rubin R (Cancer research 1997) 2 3 4 60
  2. Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules. (PMID: 22334682) Han BG … Lee BI (The Journal of biological chemistry 2012) 3 4 60
  3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 45 60
  4. The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation. (PMID: 19387494) Rigou P … Poyet JL (The EMBO journal 2009) 3 4 60
  5. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. (PMID: 17112319) Morris EJ … Dyson NJ (PLoS genetics 2006) 3 4 60

Products for API5 Gene

  • Addgene plasmids for API5

Sources for API5 Gene

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