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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

API5 Gene

protein-coding   GIFtS: 54
GCID: GC11P043290

apoptosis inhibitor 5
 Explore 10 diseases affiliated with
API5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for API5    

Aliases
for API5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Apoptosis Inhibitor 51 2     API5L11
AAC-111 2 3     Fibroblast Growth Factor 2-Interacting Factor 22
AAC111 2 5     Migration-Inducing Protein MIG82
Antiapoptosis Clone 11 Protein2 3     API-53
Cell Migration-Inducing Gene 8 Protein2 3     Fibroblast Growth Factor 2-Interacting Factor3
FIF2 3     Protein XAGL3

External Ids:    HGNC: 5941   Entrez Gene: 85392   Ensembl: ENSG000001661817   OMIM: 6097745   UniProtKB: Q9BZZ53   
ORGUL members:         
NONCODE:n407119    

Export aliases for API5 gene to outside databases

Previous GC identifers: GC11M045153 GC11P044016 GC11P043372 GC11P043297 GC11P043043


Summaries
for API5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for API5:
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation.
This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively
regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic
action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms
have been identified. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: API5_HUMAN, Q9BZZ5
Function: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to
ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently
suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs

Gene Wiki entry for API5


Genomic Views
for API5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the API5 gene promoter:
         Bach1   SRF   SRF (504 AA)   Nkx2-5   HNF-1A   Max   HNF-1   Sox9   ZID   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): API5 promoter sequence
   Search SABiosciences Chromatin IP Primers for API5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat API5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p12   HGNC cytogenetic band: 11p12

API5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
API5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P043290:  view genomic region     (about GC identifiers)

Start:
 43,333,505 bp from pter      End:
 43,366,080 bp from pter
Size:
 32,576 bases      Orientation:
 plus strand

Proteins
for API5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: API5_HUMAN, Q9BZZ5 (See protein sequence)
Recommended Name: Apoptosis inhibitor 5  
Size: 524 amino acids; 59005 Da
Subunit: Monomer. Interacts with FGF2 and ACIN1
Subcellular location: Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic
Subcellular location: Isoform 3: Cytoplasm
Sequence caution: Sequence=AAB86528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAB86528.1; Type=Frameshift; Positions=Several;
2 PDB 3D structures from and Proteopedia for API5:
3U0R (3D)        3V6A (3D)    
Secondary accessions: B4DGR0 B4DRJ2 D3DR21 O15441 Q9Y4J7
Alternative splicing: 5 isoforms:  Q9BZZ5-4   Q9BZZ5-1   Q9BZZ5-2   Q9BZZ5-3   Q9BZZ5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for API5: NX_Q9BZZ5

Post-translational modifications:

  • Acetylation at Lys-251 impairs antiapoptotic function1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BZZ5

    • API5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001136402.1  NP_001136403.1  NP_001230676.1  NP_006586.1  

    ENSEMBL proteins: 
     ENSP00000436189   ENSP00000399341   ENSP00000431391   ENSP00000402540   ENSP00000368129  
     ENSP00000434462   ENSP00000436436  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: API5
    OriGene Protein Over-expression Lysate: API5
    OriGene Custom Protein Services for API5 
    GenScript Custom Purified and Recombinant Proteins Services for API5
    Novus Biologicals API5 Protein
    Novus Biologicals API5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for API5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex ISS11555636
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS11075807


    API5 for ontologies           About GeneDecksing



    API5 Antibody Products: 
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    Novus Biologicals API5 Antibodies
    Search for Antibodies for API5 at Abcam  
    Uscn Antibodies for API5
    Search ThermoFisher Antibodies for API5

    Assay Products for API5: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for API5
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    Uscn ELISAs and CLIAs for API5

    Protein Domains /
    Families
    for API5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    API5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011989 ARM-like
     IPR008383 API5
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9BZZ5

    ProtoNet protein and cluster: Q9BZZ5

    UniProtKB/Swiss-Prot: API5_HUMAN, Q9BZZ5
    Domain: Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2
    Similarity: Belongs to the API5 family


    Function
    for API5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: API5_HUMAN, Q9BZZ5
    Function: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to
    ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently
    suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs

         Genatlas biochemistry entry for API5:
    antiapoptosis 5,inhibiting apoptosis after growth factor withdrawal,ubiquitously expressed

    miRNA
    Products:            		miRTarBase miRNAs that target API5:
    hsa-mir-224 (MIRT003987)

    OriGene 3'-UTR Clone (see all 3): API5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat API5
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate API5 (see all 17):
    hsa-miR-3673 hsa-miR-4251 hsa-miR-520d-5p hsa-miR-485-3p hsa-miR-340 hsa-miR-3133 hsa-miR-548m hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmid: API5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for API5 (see all 7)
    OriGene shRNA RFP: API5
    OriGene siRNA: API5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat API5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for API5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for API5 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for API5 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): API5 (NM_006595)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for API5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat API5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for API5
    Search LifeMap BioReagents cell lines for API5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for API5

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017134fibroblast growth factor binding IPI11075807


    API5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for API5:
     Decreased nuclei size in G2M  Synthetic lethal with imatinib 


    Pathways & Interactions
    for API5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for API5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/563 Interacting proteins for API5 (Q9BZZ52, 3 ENSP000003993414) via UniProtKB, MINT, STRING, and/or I2D (see all 563)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3MINT-7945693 I2D: score=5 
    ACIN1Q9UKV32, 3, ENSP000002627104MINT-7289283 MINT-7289297 MINT-7945693 MINT-7289318 MINT-7289249 MINT-7289353 I2D: score=1 STRING: ENSP00000262710
    CHD1LQ86WJ12, 3, ENSP000003582624MINT-7945693 I2D: score=1 STRING: ENSP00000358262
    FGF2P090383, ENSP000002644984I2D: score=1 STRING: ENSP00000264498
    PRKAB1Q9Y4783, ENSP000002293284I2D: score=1 STRING: ENSP00000229328
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0043066negative regulation of apoptotic process NAS10780674


    API5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for API5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for API5
    Search CenterWatch for drugs/clinical trials and news about API5 

    Transcripts
    for API5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for API5 gene (4 alternative transcripts): 
    NM_001142930.1  NM_001142931.1  NM_001243747.1  NM_006595.3  

    Unigene Cluster for API5:

    Apoptosis inhibitor 5
    Hs.435771  [show with all ESTs]
    Unigene Representative Sequence: NR_024625
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534695 ENST00000455725 ENST00000530300 ENST00000531273 ENST00000420461
    ENST00000378852(uc010rfh.1 uc001mxf.2 uc010rfg.1 uc010rfi.1 uc021qgi.1)
    ENST00000534600(uc001mxg.3) ENST00000526394 ENST00000532267 ENST00000529932
    ENST00000529334

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): API5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat API5
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate API5 (see all 17):
    hsa-miR-3673 hsa-miR-4251 hsa-miR-520d-5p hsa-miR-485-3p hsa-miR-340 hsa-miR-3133 hsa-miR-548m hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmid: API5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for API5 (see all 7)
    OriGene shRNA RFP: API5
    OriGene siRNA: API5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat API5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for API5 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for API5 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): API5 (NM_006595)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for API5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat API5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for API5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat API5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat API5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat API5

    Additional cDNA sequence: 

    AF229253.1 AF229254.1 AK293303.1 AK294724.1 AK299288.1 AK304157.1 AY311389.1 BC017709.1 
    BT007093.1 NR_024625.1 Y15906.1 

    24/25 DOTS entries (see all 25):

    DT.102835735  DT.100843950  DT.448475  DT.100822502  DT.100822503  DT.120736066  DT.91773498  DT.100822501 
    DT.121281172  DT.120736196  DT.100822508  DT.120736072  DT.120736113  DT.100822506  DT.120736134  DT.120736141 
    DT.120736227  DT.121296373  DT.40109541  DT.40215237  DT.91773494  DT.91773496  DT.95292487  DT.97816307 

    24/453 AceView cDNA sequences (see all 453):

    BE504317 AI419013 CB250393 AK021649 AA926921 AI686219 AU131416 CR593210 
    AI801247 AA855086 BM460015 BU684186 BQ069172 AU279777 BU634498 AA778847 
    AI264960 BP338460 BM680253 AL046216 CA771236 CB321614 BM689575 AU136080 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for API5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                    -           -                                                                                       
    SP2:                                -                                                                                       
    SP3:                                                                                                                        
    SP4:                    -                                                                                                   


    ECgene alternative splicing isoforms for API5

    Expression
    for API5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    API5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATTTTTTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    API5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSecondary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See API5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for API5

    SOURCE GeneReport for Unigene cluster: Hs.435771

    UniProtKB/Swiss-Prot: API5_HUMAN, Q9BZZ5
    Tissue specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle,
    kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers.
    Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer

        SABiosciences Expression via Pathway-Focused PCR Arrays including API5: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for API5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat API5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat API5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat API5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for API5

    Orthologs
    for API5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for API5 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Api51 , 5 apoptosis inhibitor 51, 5 89.85(n)1
    98.2(a)1    		   2 (51.84 cM)5
    118001  NM_007466.21  NP_031492.21 
     944116825 
    chicken
    (Gallus gallus)    		 Aves API51 apoptosis inhibitor 5 81.33(n)
    94.65(a)    		   423168  NM_001006474.1  NP_001006474.1 
    lizard
    (Anolis carolinensis)    		 Reptilia API56
    		 --
    		 93(a)
    		 1 ↔ 1
    		 1(50690080-50706097)
    African clawed frog
    (Xenopus laevis)    		 Amphibia srnyz021-prov2 apoptosis inhibitor 5 76.16(n)    BC043906.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii srnyz0212 srnyz021 78.34(n)   321343  BC057483.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Aac111 , 3 anti-apoptosis apoptosis inhibitor3
    Aac111    		 46(a)3
    52.64(n)1
    48.73(a)1    		   36C93
    350531  NM_058106.41  NP_477454.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G290301 Apoptosis inhibitory protein 5 47.29(n)
    35.57(a)    		   839777  NM_102644.4  NP_174198.2 
    rice
    (Oryza sativa)    		 Liliopsida Os02g03134001 hypothetical protein 43.14(n)
    31.51(a)    		   4329135  NM_001053191.1  NP_001046656.1 


    ENSEMBL Gene Tree for API5 (if available)
    TreeFam Gene Tree for API5 (if available) 

    Paralogs
    for API5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for API5 gene

    API5 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for API5
    PGOHUM00000258135 PGOHUM00000240441 PGOHUM00000261809 PGOHUM00000241507


    Genomic Variants
    for API5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/485 NCBI SNPs in API5 are shown (see all 485)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs752230311,2
    		F,--43041639(+) TTCCCG/ATGTAT 5 -- us2k11Minor allele frequency- A:0.03WA 118
    rs57432111,2
    		C,F,--43043769(+) AGGTGT/CAATAG 5 -- ut51 nc-transcript-variant2Minor allele frequency- C:0.02NS WA 178
    rs57432131,2
    		C,F,H,--43044045(+) CCCGGG/AGCCTC 5 -- int110Minor allele frequency- A:0.21NS EA NA WA CSA 713
    rs57432141,2
    		C,F,H--43044078(+) TCGGGG/TTGGGC 5 -- int17Minor allele frequency- T:0.01NS EA NA 800
    rs118235391,2
    		C,F,A,H,--43044436(+) ATGAGA/GGCTCA 5 -- int128Minor allele frequency- G:0.25NS EA NA WA CSA 2982
    rs118282671,2
    		C,F,H,--43044669(+) tgaaaC/Acctgt 5 -- int12Minor allele frequency- A:0.37NA WA 8
    rs799536211,2
    		F,--43044963(+) GTTGTC/GTGGAA 5 -- int11Minor allele frequency- G:0.03WA 118
    rs735473801,2
    		C,--43045028(+) TATCCG/ATACAA 5 -- int11Minor allele frequency- A:0.50WA 2
    rs110374131,2
    		C,H--43046818(+) TCCTTC/GTAACT 5 -- int14Minor allele frequency- G:0.00NS EA 418
    rs743639151,2
    		C,F,--43047026(+) AACCCC/ATTGGT 5 -- int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for API5 (43333505 - 43366080 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for API5
         2 CNVs: 85747 75626

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing API5
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    Disorders / Diseases
    for API5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    API5 for disorders           About GeneDecksing

    OMIM gene information: 609774    OMIM disorders: --

    10 diseases for API5:    About MalaCards
    squamous cell carcinoma    hepatocellular carcinoma    cervical cancer    cervicitis
    lung cancer    adenocarcinoma    breast cancer    carcinoma
    leukemia    lymphoid leukemia


    Export disorders for API5 gene to outside databases

    Publications
    for API5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for API5 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with API5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. (PubMed id 9307294)1, 2, 3 Tewari M.... Rubin R. (1997)
    2. Helical repeat structure of apoptosis inhibitor 5 reveals protein- protein interaction modules. (PubMed id 22334682)1, 2 Han B.G.... Lee B.I. (2012)
    3. The antiapoptotic protein AAC-11 interacts with and regulates Acinus- mediated DNA fragmentation. (PubMed id 19387494)1, 2 Rigou P....Poyet J.-L. (2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. (PubMed id 17112319)1, 2 Morris E.J.... Dyson N.J. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. (PubMed id 10780674)1, 2 Kim J.W....Namkoong S.E. (2000)
    9. FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. (PubMed id 11075807)1, 2 Van den Berghe L....Bugler B. (2000)
    10. Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. (PubMed id 10393420)1, 2 Gianfrancesco F.... Forabosco A. (1999)

    External Searches for API5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing API5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8539 HGNC: 594 AceView: API5 Ensembl:ENSG00000166181 euGenes: HUgn8539
    ECgene: API5 H-InvDB: API5

    Other Databases showing API5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing API5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for API5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for API5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/api5/

    Intellectual Property
    for API5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for API5 gene:
    Search GeneIP for patents involving API5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
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    About This Section

     
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     Regulatory tfbs in API5 promoter
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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