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API5 Gene

protein-coding   GIFtS: 55
GCID: GC11P043333

Apoptosis Inhibitor 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apoptosis Inhibitor 51 2     FIF2 3
Fibroblast Growth Factor 2-Interacting Factor 21 2     AAC112 5
Migration-Inducing Protein MIG81 2     API5-Like 11
Antiapoptosis Clone 11 Protein2 3     API-53
Cell Migration-Inducing Gene 8 Protein2 3     Fibroblast Growth Factor 2-Interacting Factor3
AAC-112 3     Protein XAGL3

External Ids:    HGNC: 5941   Entrez Gene: 85392   Ensembl: ENSG000001661817   OMIM: 6097745   UniProtKB: Q9BZZ53   

Export aliases for API5 gene to outside databases

Previous GC identifers: GC11M045153 GC11P044016 GC11P043372 GC11P043297 GC11P043290 GC11P043043


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for API5 Gene:
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor
deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and
negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the
cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding
different isoforms have been identified. (provided by RefSeq, Aug 2011)

GeneCards Summary for API5 Gene:
API5 (apoptosis inhibitor 5) is a protein-coding gene. GO annotations related to this gene include fibroblast growth factor binding.

UniProtKB/Swiss-Prot: API5_HUMAN, Q9BZZ5
Function: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to
ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently
suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs

Gene Wiki entry for API5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the API5 gene promoter:
         Bach1   SRF   SRF (504 AA)   Nkx2-5   HNF-1A   Max   HNF-1   Sox9   ZID   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): API5 promoter sequence
   Search Chromatin IP Primers for API5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat API5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p12   HGNC cytogenetic band: 11p12

API5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
API5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P043333:  view genomic region     (about GC identifiers)

Start:
43,333,505 bp from pter      End:
43,366,080 bp from pter
Size:
32,576 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: API5_HUMAN, Q9BZZ5 (See protein sequence)
Recommended Name: Apoptosis inhibitor 5  
Size: 524 amino acids; 59005 Da
Subunit: Monomer. Interacts with FGF2 and ACIN1
Sequence caution: Sequence=AAB86528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAB86528.1; Type=Frameshift; Positions=Several;
2 PDB 3D structures from and Proteopedia for API5:
3U0R (3D)        3V6A (3D)    
Secondary accessions: B4DGR0 B4DRJ2 D3DR21 O15441 Q9Y4J7
Alternative splicing: 5 isoforms:  Q9BZZ5-4   Q9BZZ5-1   Q9BZZ5-2   Q9BZZ5-3   Q9BZZ5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for API5: NX_Q9BZZ5

Explore proteomics data for API5 at MOPED

Post-translational modifications: 

  • Acetylation at Lys-251 impairs antiapoptotic function1
  • Ubiquitination2 at Lys12
  • Modification sites at PhosphoSitePlus

  • See API5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001136402.1  NP_001136403.1  NP_001230676.1  NP_006586.1  

    ENSEMBL proteins: 
     ENSP00000436189   ENSP00000399341   ENSP00000431391   ENSP00000402540   ENSP00000368129  
     ENSP00000434462   ENSP00000436436  

    API5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for API5
    OriGene Protein Over-expression Lysate for API5
    OriGene MassSpec for API5
    OriGene Custom Protein Services for API5
    GenScript Custom Purified and Recombinant Proteins Services for API5
    Novus Biologicals API5 Protein
    Novus Biologicals API5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for API5

     
    Search eBioscience for Proteins for API5 

     
    antibodies-online proteins for API5 (3 products) 

     
    antibodies-online peptides for API5

    API5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for API5
    OriGene Custom Antibody Services for API5
    Novus Biologicals API5 Antibodies
    Abcam antibodies for API5
    Cloud-Clone Corp. Antibodies for API5
    Search ThermoFisher Antibodies for API5
    antibodies-online antibodies for API5 (49 products) 

    API5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for API5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for API5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for API5
    Cloud-Clone Corp. CLIAs for API5
    Search eBioscience for ELISAs for API5 
    antibodies-online kits for API5 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR008383 API5
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9BZZ5

    ProtoNet protein and cluster: Q9BZZ5

    UniProtKB/Swiss-Prot: API5_HUMAN, Q9BZZ5
    Domain: Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2
    Similarity: Belongs to the API5 family


    Find genes that share domains with API5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: API5_HUMAN, Q9BZZ5
    Function: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to
    ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently
    suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs

         Genatlas biochemistry entry for API5:
    antiapoptosis 5,inhibiting apoptosis after growth factor withdrawal,ubiquitously expressed

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI19387494
    GO:0017134fibroblast growth factor binding IPI11075807
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with API5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for API5:
     Decreased nuclei size in G2M  Synthetic lethal with imatinib 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for API5

    miRNA
    Products:
        
    miRTarBase miRNAs that target API5:
    hsa-mir-183-5p (MIRT025015), hsa-mir-224-5p (MIRT003987)

    Block miRNA regulation of human, mouse, rat API5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate API5 (see all 17):
    hsa-miR-3673 hsa-miR-4251 hsa-miR-520d-5p hsa-miR-485-3p hsa-miR-340 hsa-miR-3133 hsa-miR-548m hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidAPI5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for API5
    Predesigned siRNA for gene silencing in human, mouse, rat API5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for API5

    Clone
    Products:
         
    OriGene clones in human, mouse for API5 (see all 17)
    OriGene ORF clones in mouse, rat for API5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): API5 (NM_006595)
    Sino Biological Human cDNA Clone for API5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for API5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat API5
    Addgene plasmids for API5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for API5
    Browse ESI BIO Cell Lines and PureStem Progenitors for API5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for API5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    API5_HUMAN, Q9BZZ5: Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic
    API5_HUMAN, Q9BZZ5: Isoform 3: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus2
    peroxisome2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex ISS11555636
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS11075807

    Find genes that share ontologies with API5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including API5: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for API5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for API5 (Q9BZZ51, 2, 3 ENSP000003993414) via UniProtKB, MINT, STRING, and/or I2D (see all 592)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3MINT-7945693 I2D: score=5 
    ENSG00000215425Q138382, 3MINT-7945693 I2D: score=5 
    ENSG00000225073Q138382, 3MINT-7945693 I2D: score=5 
    ENSG00000225859Q138382, 3MINT-7945693 I2D: score=5 
    ENSG00000229496Q138382, 3MINT-7945693 I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0043066negative regulation of apoptotic process NAS10780674
    GO:2000270negative regulation of fibroblast apoptotic process IEA--

    Find genes that share ontologies with API5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for API5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for API5 gene (4 alternative transcripts): 
    NM_001142930.1  NM_001142931.1  NM_001243747.1  NM_006595.3  

    Unigene Cluster for API5:

    Apoptosis inhibitor 5
    Hs.435771  [show with all ESTs]
    Unigene Representative Sequence: NR_024625
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534695 ENST00000455725 ENST00000530300 ENST00000531273 ENST00000420461
    ENST00000378852(uc010rfh.1 uc001mxf.2 uc010rfg.1 uc010rfi.1 uc021qgi.1)
    ENST00000534600(uc001mxg.3) ENST00000526394 ENST00000532267 ENST00000529932
    ENST00000529334
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat API5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate API5 (see all 17):
    hsa-miR-3673 hsa-miR-4251 hsa-miR-520d-5p hsa-miR-485-3p hsa-miR-340 hsa-miR-3133 hsa-miR-548m hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidAPI5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for API5
    Predesigned siRNA for gene silencing in human, mouse, rat API5
    Clone
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    OriGene clones in human, mouse for API5 (see all 17)
    OriGene ORF clones in mouse, rat for API5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): API5 (NM_006595)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for API5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat API5
    Addgene plasmids for API5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for API5
    OriGene qSTAR qPCR primer pairs in human, mouse for API5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat API5
      QuantiTect SYBR Green Assays in human, mouse, rat API5
      QuantiFast Probe-based Assays in human, mouse, rat API5

    Additional mRNA sequence: 

    AF229253.1 AF229254.1 AK293303.1 AK294724.1 AK299288.1 AK304157.1 AY311389.1 BC017709.1 
    BT007093.1 NR_024625.1 Y15906.1 

    Selected DOTS entries (see all 25):

    DT.102835735  DT.100843950  DT.448475  DT.100822502  DT.100822503  DT.120736066  DT.91773498  DT.100822501 
    DT.121281172  DT.100822508  DT.120736196  DT.120736072  DT.120736113  DT.100822506  DT.120736134  DT.120736141 
    DT.120736227  DT.121296373  DT.40109541  DT.40215237  DT.91773494  DT.91773496  DT.95292487  DT.97816307 

    Selected AceView cDNA sequences (see all 453):

    AA808458 AI379120 AF229253 AI188009 BT007093 BG027507 AA854594 CN478884 
    AU124574 AU125893 BM789567 AA031321 AU130361 BP365086 BE504317 BM836841 
    AI141966 BF115210 CR598402 CA430703 AI381348 C18842 AW440762 AW511439 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for API5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                    -           -                                                                                       
    SP2:                                -                                                                                       
    SP3:                                                                                                                        
    SP4:                    -                                                                                                   


    ECgene alternative splicing isoforms for API5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    API5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTTTTTC
    API5 Expression
    About this image


    API5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Brain (Nervous System)
             Cerebellum
    API5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    API5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435771

    UniProtKB/Swiss-Prot: API5_HUMAN, Q9BZZ5
    Tissue specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal
    muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers.
    Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including API5: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for API5
    OriGene qSTAR qPCR primer pairs in human, mouse for API5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat API5
    QuantiTect SYBR Green Assays in human, mouse, rat API5
    QuantiFast Probe-based Assays in human, mouse, rat API5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for API5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for API5 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Api51 , 5 apoptosis inhibitor 51, 5 89.85(n)1
    98.2(a)1
      2 (51.84 cM)5
    118001  NM_007466.21  NP_031492.21 
     944116825 
    chicken
    (Gallus gallus)
    Aves API51 apoptosis inhibitor 5 81.63(n)
    95.19(a)
      423168  NM_001006474.1  NP_001006474.1 
    lizard
    (Anolis carolinensis)
    Reptilia API56
    apoptosis inhibitor 5
    93(a)
    1 ↔ 1
    1(50689845-50709178)
    African clawed frog
    (Xenopus laevis)
    Amphibia srnyz021-prov2 apoptosis inhibitor 5 76.16(n)    BC043906.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srnyz0212 srnyz021 78.34(n)   321343  BC057483.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aac111 , 3 anti-apoptosis apoptosis inhibitor3
    Aac111
    46(a)3
    52.82(n)1
    48.68(a)1
      36C93
    350531  NM_058106.51  NP_477454.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G290301 AT1G29030 49.13(n)
    37.02(a)
      839777  NM_102644.4  NP_174198.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g03134001 Os02g0313400 43.7(n)
    31.1(a)
      4329135  NM_001053191.1  NP_001046656.1 


    ENSEMBL Gene Tree for API5 (if available)
    TreeFam Gene Tree for API5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for API5 gene

    Find genes that share paralogs with API5           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for API5
    PGOHUM00000258135 PGOHUM00000240441 PGOHUM00000261809 PGOHUM00000241507


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for API5 (see all 648)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1924018041,2
    --43043053(+) ATTAAC/TATATA 5 -- us2k10--------
    rs1849439811,2
    --43043061(+) ATAATA/GTTATA 5 -- us2k10--------
    rs1881414241,2
    --43260238(+) CTCCCC/TGCTTA 5 -- us2k10--------
    rs1909694111,2
    C--43260239(+) TCCCCA/G/TCTTAG 5 -- us2k10--------
    rs752230311,2
    F--43260368(+) TTCCCG/ATGTAT 5 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1431334111,2
    C--43260543(+) TTAAC-/TTTTCT
            
    TTTTC
    5 -- us2k10--------
    rs1427525991,2
    --43260692(+) CTCTCA/GTGCAG 5 -- us2k10--------
    rs125771141,2
    C,H--43260758(+) GACAGC/GGTTTC 5 -- us2k11Minor allele frequency- G:0.00NA 2
    rs1826787181,2
    --43260773(+) TGTTGA/GCCAGG 5 -- us2k10--------
    rs1388403521,2
    --43260885(+) ATATTA/GTTATA 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for API5 (43333505 - 43366080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for API5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270488CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing API5
    DNA2.0 Custom Variant and Variant Library Synthesis for API5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609774    OMIM disorders: --


    Find genes that share disorders with API5           About GenesLikeMe

    Genetic Association Database (GAD): API5

    Export disorders for API5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for API5 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with API5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. (PubMed id 9307294)1, 2, 3 Tewari M.... Rubin R. (Cancer Res. 1997)
    2. Helical repeat structure of apoptosis inhibitor 5 reveals protein- protein interaction modules. (PubMed id 22334682)1, 2 Han B.G.... Lee B.I. (J. Biol. Chem. 2012)
    3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    4. The antiapoptotic protein AAC-11 interacts with and regulates Acinus- mediated DNA fragmentation. (PubMed id 19387494)1, 2 Rigou P....Poyet J.-L. (EMBO J. 2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. (PubMed id 17112319)1, 2 Morris E.J.... Dyson N.J. (PLoS Genet. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. (PubMed id 10780674)1, 2 Kim J.W....Namkoong S.E. (Lab. Invest. 2000)
    10. FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. (PubMed id 11075807)1, 2 Van den Berghe L....Bugler B. (Mol. Endocrinol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8539 HGNC: 594 AceView: API5 Ensembl:ENSG00000166181 euGenes: HUgn8539
    ECgene: API5 H-InvDB: API5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for API5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for API5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/api5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for API5 gene:
    Search GeneIP for patents involving API5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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