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Aliases for API5 Gene

Aliases for API5 Gene

  • Apoptosis Inhibitor 5 2 3
  • Fibroblast Growth Factor 2-Interacting Factor 2 2 3
  • Cell Migration-Inducing Gene 8 Protein 3 4
  • Migration-Inducing Protein MIG8 2 3
  • Antiapoptosis Clone 11 Protein 3 4
  • AAC-11 3 4
  • AAC11 3 6
  • FIF 3 4
  • Fibroblast Growth Factor 2-Interacting Factor 4
  • Protein XAGL 4
  • API5-Like 1 2
  • API-5 4

External Ids for API5 Gene

Summaries for API5 Gene

Entrez Gene Summary for API5 Gene

  • This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for API5 Gene

API5 (Apoptosis Inhibitor 5) is a Protein Coding gene. GO annotations related to this gene include fibroblast growth factor binding.

UniProtKB/Swiss-Prot for API5 Gene

  • Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Gene Wiki entry for API5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for API5 Gene

Genomics for API5 Gene

Genomic Location for API5 Gene

Start:
43,311,955 bp from pter
End:
43,344,530 bp from pter
Size:
32,576 bases
Orientation:
Plus strand

Genomic View for API5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for API5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for API5 Gene

Regulatory Elements for API5 Gene

Proteins for API5 Gene

  • Protein details for API5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZZ5-API5_HUMAN
    Recommended name:
    Apoptosis inhibitor 5
    Protein Accession:
    Q9BZZ5
    Secondary Accessions:
    • B4DGR0
    • B4DRJ2
    • B4E283
    • D3DR21
    • O15441
    • Q9Y4J7

    Protein attributes for API5 Gene

    Size:
    524 amino acids
    Molecular mass:
    59005 Da
    Quaternary structure:
    • Monomer. Interacts with FGF2 and ACIN1.
    SequenceCaution:
    • Sequence=AAB86528.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB86528.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for API5 Gene

    Alternative splice isoforms for API5 Gene

neXtProt entry for API5 Gene

Proteomics data for API5 Gene at MOPED

Post-translational modifications for API5 Gene

  • Acetylation at Lys-251 impairs antiapoptotic function.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys12, Lys51, and Lys487

No data available for DME Specific Peptides for API5 Gene

Domains for API5 Gene

Protein Domains for API5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

API5_HUMAN
Domain:
  • Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2:
    • Q9BZZ5
Family:
  • Belongs to the API5 family.:
    • Q9BZZ5
genes like me logo Genes that share domains with API5: view

No data available for Gene Families for API5 Gene

Function for API5 Gene

Molecular function for API5 Gene

GENATLAS Biochemistry: antiapoptosis 5,inhibiting apoptosis after growth factor withdrawal,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Gene Ontology (GO) - Molecular Function for API5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 19387494
GO:0017134 fibroblast growth factor binding IPI 11075807
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with API5: view

Phenotypes for API5 Gene

genes like me logo Genes that share phenotypes with API5: view

miRNA for API5 Gene

miRTarBase miRNAs that target API5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for API5 Gene

Localization for API5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for API5 Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for API5 Gene COMPARTMENTS Subcellular localization image for API5 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for API5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11075807
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex ISS 11555636
GO:0005737 cytoplasm NAS 11075807
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with API5: view

Pathways for API5 Gene

SuperPathways for API5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for API5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0043066 negative regulation of apoptotic process NAS 10780674
GO:2000270 negative regulation of fibroblast apoptotic process IEA --
genes like me logo Genes that share ontologies with API5: view

No data available for Pathways by source for API5 Gene

Transcripts for API5 Gene

Unigene Clusters for API5 Gene

Apoptosis inhibitor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for API5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2: -
SP3:
SP4: -

Relevant External Links for API5 Gene

GeneLoc Exon Structure for
API5
ECgene alternative splicing isoforms for
API5

Expression for API5 Gene

mRNA expression in normal human tissues for API5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for API5 Gene

SOURCE GeneReport for Unigene cluster for API5 Gene Hs.435771

mRNA Expression by UniProt/SwissProt for API5 Gene

Q9BZZ5-API5_HUMAN
Tissue specificity: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
genes like me logo Genes that share expressions with API5: view

Orthologs for API5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for API5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia API5 36
  • 99.87 (n)
  • 100 (a)
API5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia API5 36
  • 93.39 (n)
  • 98.6 (a)
API5 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia API5 36
  • 93.64 (n)
  • 98.85 (a)
API5 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Api5 36
  • 89.85 (n)
  • 98.2 (a)
Api5 16
Api5 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia API5 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia API5 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Api5 36
  • 90.51 (n)
  • 98.6 (a)
chicken
(Gallus gallus)
Aves API5 36
  • 81.63 (n)
  • 95.19 (a)
API5 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia API5 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia srnyz021-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia api5 36
  • 74.42 (n)
  • 86.17 (a)
Str.5903 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6581 36
zebrafish
(Danio rerio)
Actinopterygii api5 36
  • 73.05 (n)
  • 84.07 (a)
api5 37
  • 82 (a)
OneToOne
srnyz021 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009645 36
  • 53.79 (n)
  • 52.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aac11 36
  • 52.82 (n)
  • 48.68 (a)
Aac11 37
  • 45 (a)
OneToOne
Aac11 38
  • 46 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29030 36
  • 49.13 (n)
  • 37.02 (a)
rice
(Oryza sativa)
Liliopsida Os02g0313400 36
  • 43.7 (n)
  • 31.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToOne
Species with no ortholog for API5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for API5 Gene

ENSEMBL:
Gene Tree for API5 (if available)
TreeFam:
Gene Tree for API5 (if available)

Paralogs for API5 Gene

Pseudogenes.org Pseudogenes for API5 Gene

genes like me logo Genes that share paralogs with API5: view

No data available for Paralogs for API5 Gene

Variants for API5 Gene

Sequence variations from dbSNP and Humsavar for API5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs14754 -- 43,344,358(+) CCCTT(C/T)CCCTT utr-variant-3-prime, nc-transcript-variant
rs1056535 -- 43,344,447(+) TTTTT(C/T)TTTTG utr-variant-3-prime, nc-transcript-variant
rs1143463 -- 43,320,874(-) CGAGG(A/G)AGGTT synonymous-codon, reference, nc-transcript-variant
rs1804963 -- 43,323,451(+) CTGGT(C/G)AAGAA missense, reference, intron-variant, nc-transcript-variant
rs2036065 -- 43,334,270(+) TGAAT(C/T)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for API5 Gene

Variant ID Type Subtype PubMed ID
esv270488 CNV Insertion 20981092

Relevant External Links for API5 Gene

HapMap Linkage Disequilibrium report
API5

Disorders for API5 Gene

Relevant External Links for API5

Genetic Association Database (GAD)
API5
genes like me logo Genes that share disorders with API5: view

No data available for UniProtKB/Swiss-Prot for API5 Gene

Publications for API5 Gene

  1. AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. (PMID: 9307294) Tewari M. … Rubin R. (Cancer Res. 1997) 2 3 4
  2. Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. (PMID: 10393420) Gianfrancesco F. … Forabosco A. (Cytogenet. Cell Genet. 1999) 3 4
  3. AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. (PMID: 10780674) Kim J.W. … Namkoong S.E. (Lab. Invest. 2000) 3 4
  4. FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. (PMID: 11075807) Van den Berghe L. … Bugler B. (Mol. Endocrinol. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for API5 Gene

Sources for API5 Gene

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