Aliases for APH1B Gene
External Ids for APH1B Gene
Previous GeneCards Identifiers for APH1B Gene
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
GeneCards Summary for APH1B Gene
APH1B (Aph-1 Homolog B, Gamma Secretase Subunit) is a Protein Coding gene. Among its related pathways are ERK Signaling and Syndecan-3-mediated signaling events. GO annotations related to this gene include peptidase activity. An important paralog of this gene is APH1A.
UniProtKB/Swiss-Prot for APH1B Gene
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.