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APH1B Gene

protein-coding GIFtS: 53

GC15P061357

anterior pharynx defective 1 homolog B (C. elegans)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
APH-1B ^¹, ²
APH-1b ^³
Aph-1beta ^³
DKFZp564D0372 ^¹, ²
FLJ33115 ^²
PRO1328 ^²
PSFL ^¹, ², ³
TAAV688 ^²

Descriptions
Presenilin-stabilization factor-like ^³
anterior pharynx defective 1 homolog B (C. elegans) ^²
anterior pharynx defective 1B-like ^²
presenilin stabilization factor-like ^²

External Ids
HGNC: 24080¹
Entrez Gene: 83464²
UniProtKB: Q8WW43³
Ensembl: ENSG00000138613⁷

Search outside databases for aliases for APH1B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for APH1B:

APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311)

and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The

gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane

proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM

190198).[supplied by OMIM]

UniProtKB/Swiss-Prot: APH1B_HUMAN, Q8WW43

Function: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes

the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid

precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer

that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase

complexes compared to APH1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the APH1B gene

Entrez Gene cytogenetic band: 15q22.2 Ensembl cytogenetic band: 15q22.2 HGNC cytogenetic band: 15q22.2

APH1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P061357: (about GC identifiers)

Start:	61,356,844 bp from pter
End:	61,385,807 bp from pter
Size:	28,964 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: APH1B_HUMAN, Q8WW43 (See protein sequence)

Recommended Name: Gamma-secretase subunit APH-1B

Size: 257 amino acids; 28460 Da

Subunit: Probable component of the gamma-secretase complex, a complex composed of a presenilin

homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal

complex is sufficient for secretase activity, although other components may exist (By similarity).

Interacts with PSEN1 and PSEN2

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q6UWQ1 Q9H0S0

REFSEQ proteins (2 alternative transcripts):

NP_001139118.1 NP_112591.2

ENSEMBL proteins:

ENSP00000369697 ENSP00000369700 ENSP00000261879

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Aph 1b)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IDA	12297508
GO:0030133	transport vesicle	IDA	11256614

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Antibodies for APH1B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Aph 1b), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for APH1B

Assays for APH1B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8WW43

ProtoNet protein and cluster: Q8WW43

1 Blocks protein family: IPB009294 Aph-1

UniProtKB/Swiss-Prot: APH1B_HUMAN, Q8WW43

Similarity: Belongs to the APH-1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (APH1B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031301

Applied Biosystems Silencer® siRNAs for APH1B

Sigma-Aldrich siRNA and siRNA Panels for APH1B

Sigma-Aldrich shRNA for APH1B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for APH1B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145646
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145646
untagged cDNA clones in CMV expression vector (see all 2): NM_001145646

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_031301

UniProtKB/Swiss-Prot: APH1B_HUMAN, Q8WW43

Function: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes

the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid

precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer

that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase

complexes compared to APH1A

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Aph1b):

normal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12297508
GO:0008233	peptidase activity	IDA	12297508

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for APH1B (Your Favorite Gene powered by Ingenuity)

Amyloid Processing
Lysine Degradation
Mitochondrial Dysfunction
Molecular Mechanisms of Cancer
Notch Signaling

GeneDecks APH1B for the pathways selected above

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5/21 Interacting proteins for APH1B (ENSP00000261879³) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCSTN	ENSP00000294785³	STRING (score=.998)
PSEN1	ENSP00000326366³	STRING (score=.998)
PSEN2	ENSP00000355746³	STRING (score=.997)
PSENEN	ENSP00000222266³	STRING (score=.996)
NOTCH1	ENSP00000360765³	STRING (score=.953)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007219	Notch signaling pathway	IEA	--
GO:0016485	protein processing	IDA	12297508
GO:0043085	positive regulation of catalytic activity	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for APH1B

Sigma-Aldrich Small Molecules for APH1B:

Inhibitor

Browse Tocris compounds for APH1B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (APH1B)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031301

Sigma-Aldrich siRNA and siRNA Panels for APH1B

Sigma-Aldrich shRNA for APH1B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_031301

REFSEQ mRNAs for APH1B gene (2 alternative transcripts):

NM_001145646.1 NM_031301.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_031301

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145646
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145646
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001145646

Additional cDNA sequence:

AB189172.1 AF508794.1 AK057677.1 AK291204.1 AK307456.1 AK307725.1 AK310843.1 AL136671.1

AY358698.1 BC020905.1

6 DOTS entries:

DT.311571 DT.112952 DT.92022917 DT.75197896 DT.100842028 DT.95075202

24/164 AceView cDNA sequences (see all 164 ):

CA397429 BE218843 AW016528 BU742592 CA431257 AI279316 BM712104 AI819888

AW573194 NM_031301 CD672791 AA887975 AI693802 CA309393 AI143454 AI760754

BX398327 AW628257 AA557359 AI911870 CB163215 BX109247 BG210489 AI023997

highest scoring ESTs for APH1B:

N31710 AA578718 AA805757 AA805770 AA805773 AA808355 AA861920 AA887975 AF508794 AI001990

Unigene Cluster for APH1B:

Anterior pharynx defective 1 homolog B (C. elegans)

Hs.511703 [show with all ESTs]

Unigene Representative Sequence: NM_031301

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for APH1B (see all 8 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d
SP1:											-								-						-				-
SP2:			-		-		-		-		-		-						-						-				-
SP3:											-		-						-						-				-
SP4:											-		-						-		-		-		-				-
SP5:											-		-						-						-		-		-

About this scheme

ECgene alternative splicing isoforms for APH1B

3 Ensembl transcripts including schematic representations:

ENST00000380340 ENST00000380343 ENST00000261879

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

APH1B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for APH1B

¹ / ² / ³

7 probe-sets matching APH1B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65643_at²^{, 3}	U95-C	1	1.00	1.00	0.94	1.22	AI307757	0.20	0.12	0.17	2
91572_at²	U95-E	1	1.00	1.00	0.92	0.83	--	--	--	--	--
62125_at²^{, 3}	U95-C	2	0.94	0.97	0.84	0.97	N31710	0.80	1.00	0.91	1
221036_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_031301	0.60	0.83	0.73	1
226358_at²^{, 3}	U133-B	2	1.00	0.95	--	--	AW237258	0.20	0.17	0.18	2
221036_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226358_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks APH1B for binary patterns associated with the probe-sets selected above

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About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.511703
UniProtKB/Swiss-Prot: APH1B_HUMAN, Q8WW43
Tissue specificity: Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver,
kidney, spleen thymus, colon, skeletal muscle, heart and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for APH1B gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	APH1B¹	--	anterior pharynx defective 1 homolog B (C. elegans)	86.22(n) 82.67(a)	487589 XM_544714.2 XP_544714.2
chimpanzee (Pan troglodytes)	APH1B¹	--	anterior pharynx defective 1 homolog B (C. elegans)	99.22(n) 100(a)	467700 XM_523094.2 XP_523094.2
cow (Bos taurus)	APH1B¹	--	anterior pharynx defective 1 homolog B (C. elegans)	86.12(n) 83.27(a)	530913 XM_865991.2 XP_871084.1
rat (Rattus norvegicus)	Aph1b¹	--	anterior pharynx defective 1 homolog B (C. elegans)	86.51(n) 82.88(a)	300802 XM_217185.4 XP_217185.2
mouse (Mus musculus)	Aph1b^{1, 5}	9⁵	anterior pharynx defective 1b homolog (C. elegans)^{1, 5}	86.64(n)¹ 84.05(a)¹	208117¹ NM_177583.3¹ NP_808251.1¹ AK009964⁵ AK028521⁵ (see all 9)

About this table Species with no ortholog for APH1B

ENSEMBL Gene Tree for APH1B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for APH1B gene

APH1A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/160 NCBI SNPs in APH1B are shown (see all 160 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 69)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs745338^1,2	A,C,F,H,O	61385483(-)	`ATAAAA/CGATAA`	1	--	ng3¹		19		NS MN EU EA WA NA	2662
--	rs3784671^1,2	C,F,H	61356237(-)	`TTACCG/TTTTGG`	1	--	ng5¹		5		EA EU WA	1900
	rs1047552^1,2	C,F,H	61384910(+)	`GCATTT/GATAAT`	1	L/F	mis¹		13		MN NA EU EA WA	1240
	rs3784672^1,2	F,H	61356070(-)	`CAATTC/ATTCAA`	1	--	ng5¹		5		EA EU WA	1910
--	rs7165918^1,2	C	61356750(+)	`TGCCCA/CTGAGC`	1	--	ng5¹		0	--	--	--	--
	rs2291881^1,2	A,C,F,H,O	61384692(+)	`ATCTGC/TTGACC`	1	--	int¹		13		EA EU WA NA	2550
	rs2068143^1,2	A,C,F,H,O	61375715(+)	`TGGCAG/ATTTCT`	1	--	int¹		16		EU EA WA NA	1416
	rs7163368^1,2	A,C,F,H	61358174(+)	`GGTCAT/CTGAAA`	1	--	int¹		8		EU EA WA	840
	rs7162752^1,2	A,C,F,H	61365591(+)	`TTATGC/GGAATG`	1	--	int¹		16		NS NA EU EA WA	1064
	rs7166881^1,2	A,C,F,H	61379851(+)	`TTTCCA/GGGGTC`	1	--	int¹		12		EU EA WA NA	1054

About this table

HapMap Linkage Disequilibrium images for APH1B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607630

Human Gene Mutation Database: APH1B
Human Genome Epidemiology Navigator: APH1B (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/28 PubMed articles for APH1B gene (see all 28 ):

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{2, 3, 4} Wiemann S.... Poustka A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. (PubMed id 12740439)^{3, 4} Kimberly W.T....Selkoe D.J. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. (PubMed id 12297508)^{3, 4} Lee S.-F.... Yu G. (2002)
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. (PubMed id 12110170)^{2, 3} Francis R....Curtis D. (2002)
Identification of distinct gamma-secretase complexes with different APH-1 variants. (PubMed id 15286082)^{1, 3} Shirotani K....Steiner H. (2004)
Interaction between the APOE varepsilon4 allele and the APH-1b c+651T>G SNP in Alzheimer's disease. (PubMed id 17466415)^{1, 3} Poli M....Finazzi D. (2007)
Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes. (PubMed id 15629423)^{1, 3} Saito S. and Araki W. (2005)
Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif. (PubMed id 16757808)^{1, 3} Araki W....Murayama K.S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 83464	HGNC: 24080	AceView: PSFL	Ensembl:ENSG00000138613	euGenes: HUgn83464
ECgene: APH1B	H-InvDB: APH1B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for APH1B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for APH1B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for APH1B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for APH1B		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for APH1B		Small molecules for APH1B
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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APH1B Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for APH1B

Summaries
for APH1B

Genomic Location
for APH1B

Proteins
for APH1B

Protein Domains/
Families
for APH1B

Gene Function
for APH1B

Pathways & Interactions
for APH1B

Drugs & Compounds
for APH1B

Transcripts
for APH1B

Expression
for APH1B

Orthologs
for APH1B

Paralogs
for APH1B

SNPs/Variants
for APH1B

Disorders & Mutations
for APH1B

Medical News
for APH1B

Publications
for APH1B

Search for APH1B

Genome Databases showing APH1B

Other Databases showing APH1B

Specialized Databases showing APH1B

Licensable Technologies
for APH1B

Services
for APH1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

APH1B Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor APH1B

Summariesfor APH1B

Genomic Locationfor APH1B

Proteinsfor APH1B

Protein Domains/Familiesfor APH1B

Gene Functionfor APH1B

Pathways & Interactionsfor APH1B

Drugs & Compoundsfor APH1B

Transcriptsfor APH1B

Expression for APH1B

Orthologsfor APH1B

Paralogsfor APH1B

SNPs/Variantsfor APH1B

Disorders & Mutationsfor APH1B

Medical Newsfor APH1B

Publicationsfor APH1B

Search for APH1B

Genome Databases showing APH1B

Other Databases showing APH1B

Specialized Databases showing APH1B

Licensable Technologiesfor APH1B

Servicesfor APH1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for APH1B

Summaries
for APH1B

Genomic Location
for APH1B

Proteins
for APH1B

Protein Domains/
Families
for APH1B

Gene Function
for APH1B

Pathways & Interactions
for APH1B

Drugs & Compounds
for APH1B

Transcripts
for APH1B

Expression
for APH1B

Orthologs
for APH1B

Paralogs
for APH1B

SNPs/Variants
for APH1B

Disorders & Mutations
for APH1B

Medical News
for APH1B

Publications
for APH1B

Licensable Technologies
for APH1B

Services
for APH1B