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APH1A Gene

protein-coding GIFtS: 59

GC01M148504

anterior pharynx defective 1 homolog A (C. elegans)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
6530402N02Rik ^²
APH-1A ^¹, ²
APH-1a ^³
Aph-1alpha ^³
CGI-78 ^¹, ²
OTTHUMP00000014528 ^²
OTTHUMP00000014529 ^²
PSF ^³

Descriptions
Presenilin-stabilization factor ^³
anterior pharynx defective 1 homolog A ^²
anterior pharynx defective 1 homolog A (C. elegans) ^²

External Ids
HGNC: 29509¹
Entrez Gene: 51107²
UniProtKB: Q96BI3³
Ensembl: ENSG00000117362⁷

Search outside databases for aliases for APH1A gene

Previous GC identifer: GC01M147051

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for APH1A:

APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311)

and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The

gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane

proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM

190198).[supplied by OMIM]

UniProtKB/Swiss-Prot: APH1A_HUMAN, Q96BI3

Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes

the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid

precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer

that promotes the formation of a stable complex

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the APH1A gene

Entrez Gene cytogenetic band: 1p36.13-q31.3 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1p36.13-q31.3

APH1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M148504: (about GC identifiers)

Start:	148,502,512 bp from pter
End:	148,508,156 bp from pter
Size:	5,645 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: APH1A_HUMAN, Q96BI3 (See protein sequence)

Recommended Name: Gamma-secretase subunit APH-1A

Size: 265 amino acids; 28996 Da

Subunit: Component of the gamma-secretase complex, a complex composed of a presenilin homodimer

(PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is

sufficient for secretase activity, although other components may exist

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus,

Golgi stack membrane; Multi-pass membrane protein. Note=Predominantly located in the endoplasmic

reticulum and in the cis-Golgi

Sequence caution: Sequence=AAD34072.1; Type=Frameshift; Positions=243; Sequence=AAN63816.1;

Type=Frameshift; Positions=243;

Secondary accessions: Q969R6 Q9BVG0 Q9Y386

Alternative splicing: 2 isoforms: Q96BI3-1 Q96BI3-2

REFSEQ proteins (2 alternative transcripts):

NP_001071096.1 NP_057106.2

ENSEMBL proteins:

ENSP00000236017 ENSP00000358105 ENSP00000353380

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (APH1a)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	15274632
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005794	Golgi apparatus	IDA	15274632
GO:0005887	integral to plasma membrane	IDA	15274632
GO:0016020	membrane	IEA	--

About this table

Antibodies for APH1A:

	Invitrogen Antibodies for APH1A
	Millipore Mono- and Polyclonal Antibodies for the study of APH1A
	Sigma-Aldrich Antibodies for APH1A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (APH1a), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (APH1A)
	Novus Biologicals Antibody for APH1A

Assays for APH1A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96BI3

ProtoNet protein and cluster: Q96BI3

1 Blocks protein family: IPB009294 Aph-1

UniProtKB/Swiss-Prot: APH1A_HUMAN, Q96BI3

Similarity: Belongs to the APH-1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (APH1A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001077628

Applied Biosystems Silencer® siRNAs for APH1A

Sigma-Aldrich siRNA and siRNA Panels for APH1A

Sigma-Aldrich shRNA for APH1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for APH1A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001077628
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001077628
untagged cDNA clones in CMV expression vector (see all 3): NM_001077628

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001077628

UniProtKB/Swiss-Prot: APH1A_HUMAN, Q96BI3

Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes

the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid

precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer

that promotes the formation of a stable complex

9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Aph1a):

	craniofacial	embryogenesis	growth/size	lethality-prenatal/perinatal
muscle	nervous system	normal	skeleton

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12297508

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for APH1A (Your Favorite Gene powered by Ingenuity)

Notch Signaling
Molecular Mechanisms of Cancer
Mitochondrial Dysfunction
Amyloid Processing

GeneDecks APH1A for the pathways selected above

About GeneDecksing

5/27 Interacting proteins for APH1A (ENSP00000358105³ Q96BI3²) via UniProtKB, MINT, and/or STRING (see all 27 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCSTN	Q92542²	STRING (score=.999) MINT-6174950 MINT-7025631
PSENEN	Q9NZ42²	STRING (score=.999) MINT-7025654 MINT-7025631
PSEN1	ENSP00000326366³	STRING (score=.999)
PSEN2	ENSP00000355746³	STRING (score=.999)
NOTCH1	ENSP00000360765³	STRING (score=.972)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006509	membrane protein ectodomain proteolysis	IDA	15274632
GO:0007220	Notch receptor processing	IMP	12297508
GO:0016485	protein processing	IDA	15274632
GO:0031293	membrane protein intracellular domain proteolysis	IMP	12297508
GO:0042987	amyloid precursor protein catabolic process	IMP	12297508

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for APH1A

Sigma-Aldrich Small Molecules for APH1A:

Inhibitor

Browse Tocris compounds for APH1A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (APH1A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001077628

Sigma-Aldrich siRNA and siRNA Panels for APH1A

Sigma-Aldrich shRNA for APH1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001077628 NM_016022

REFSEQ mRNAs for APH1A gene (2 alternative transcripts):

NM_001077628.1 NM_016022.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001077628 NM_016022

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001077628
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001077628
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001077628

Additional cDNA sequence:

AF151835.1 AF508787.1 AK027879.1 AK075295.1 AK075452.1 AK297680.1 AK298832.1 AK298876.1

AK300640.1 AK307358.1 AK314490.1 AY113698.1 AY113699.1 AY358951.1 BC001230.2 BC008732.2

BC009501.2 BC015568.2 BC017699.1 BC020590.1 BC068606.1 CR590583.1 CR591178.1 CR591331.1

CR594282.1 CR594321.1 CR596144.1 CR597912.1 CR601650.1 CR603099.1 CR605320.1 CR607278.1

CR609243.1 CR609659.1 CR609960.1 CR610823.1 CR612872.1 CR613868.1 CR615087.1 CR618014.1

CR626054.1 CR626391.1 CR626622.1 CR626805.1

24/27 DOTS entries (see all 27 ):

DT.100667168 DT.92464622 DT.100667178 DT.100667165 DT.100667170 DT.92377898 DT.91947264 DT.95208829

DT.415663 DT.95370242 DT.92464637 DT.92464632 DT.95370244 DT.97855534 DT.100678619 DT.101985469

DT.92464630 DT.95370235 DT.100699928 DT.100866480 DT.121408334 DT.121408339 DT.121408344 DT.121408417

24/537 AceView cDNA sequences (see all 537 ):

BX336175 CR609659 AI583196 BX440256 BM839590 BM464560 AX775955 BQ919286

CB120774 BM770674 CA488564 AA314355 CB216714 CR591178 AI878986 BU729468

N91321 BQ012743 AI217102 AI419017 AI242398 BQ939689 AI624597 AI250157

highest scoring ESTs for APH1A:

AA314355 AF151835 AF508787 AI878986 AK027879 AK075295 AK075452 AL515915 AL516502 AL527244

Unigene Cluster for APH1A:

Anterior pharynx defective 1 homolog A (C. elegans)

Hs.108408 [show with all ESTs]

Unigene Representative Sequence: BC068606

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for APH1A (see all 6 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	·	6c	^	7
SP1:													-				-						-				-		-
SP2:													-				-						-
SP3:													-										-
SP4:									-		-		-				-						-
SP5:													-

About this scheme

ECgene alternative splicing isoforms for APH1A

3 Ensembl transcripts including schematic representations:

ENST00000236017 ENST00000369109 ENST00000360244

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

APH1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for APH1A

¹ / ² / ³

4 probe-sets matching APH1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56395_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	W52074	0.80	1.00	0.91	1
218389_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016022	0.60	1.00	0.82	1
1554417_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218389_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACATCGTAGG

SOURCE GeneReport for Unigene cluster: Hs.108408
UniProtKB/Swiss-Prot: APH1A_HUMAN, Q96BI3
Tissue specificity: Widely expressed. Expressed in leukocytes, lung, placenta, small intestine,
liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly
expressed at the same level

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for APH1A gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	APH1A¹	--	anterior pharynx defective 1 homolog A (C. elegans)	96.73(n) 99.25(a)	483181 XM_540299.2 XP_540299.1
chimpanzee (Pan troglodytes)	APH1A¹	--	anterior pharynx defective 1 homolog A (C. elegans)	99.75(n) 100(a)	457270 XM_513772.2 XP_513772.1
cow (Bos taurus)	APH1A¹	--	anterior pharynx defective 1 homolog A (C. elegans)	95.93(n) 98.37(a)	539247 NM_001034670.1 NP_001029842.1
mouse (Mus musculus)	Aph1a⁵ OTTMUSG00000021627¹	3⁵	anterior pharynx defective 1a homolog (C. elegans)⁵ predicted gene, ENSMUSG00000040323¹	94.59(n)¹ 98.87(a)¹	100039623¹ XM_001473374.1¹ XP_001473424.1¹ AI157911⁵ AK078343⁵ (see all 18)
chicken (Gallus gallus)	APH1A¹	--	anterior pharynx defective 1 homolog A (C. elegans)	64.01(n) 63.75(a)	769986 XM_001233301.1 XP_001233302.1

About this table Species with no ortholog for APH1A

ENSEMBL Gene Tree for APH1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for APH1A gene

APH1B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/20 NCBI SNPs in APH1A are shown (see all 20 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 28)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3754048^1,2	A,C,F,H	148508813(-)	`gccacC/Ggcgct`	2	--	ng3¹		4		EU EA WA	408
--	rs2275780^1,2	C,F,H	148507854(+)	`GAAGGG/TGGGTG`	2	--	ut5¹ ese³ trp³		9		EA EU WA	2312
	rs2275778^1,2	F,H	148506102(+)	`ACCAGT/GCCCGA`	2	G/G	syn¹		5		EA EU WA	1914
	rs9658936^1,2	H	148505612(+)	`GCCCAG/AAGCCC`	2	L/L	syn¹ ese³		4		EU EA WA	420
	rs9658939^1,2	H	148505639(+)	`GCATAG/AATGGG`	2	I/I	syn¹		4		EU EA WA	420
--	rs71578471^1,2	--	148509752(+)	`GCAGT-/GGGCTC`	2	--	ng3¹		0	--	--	--	--
--	rs34732118^1,2	--	148508559(+)	`ACAAG-/GAGAAT`	2	--	ng3¹		0	--	--	--	--
	rs11548267^1,2	--	148505323(-)	`TCTGCA/GCTTAT`	2	--	int¹ ut3¹		0	--	--	--	--
--	rs11548265^1,2	--	148505474(-)	`AGCCCG/TGGTCC`	2	--	int¹ ut3¹ ese³		0	--	--	--	--
--	rs35800821^1,2	--	148508583(+)	`AGGAG-/TCCTGG`	2	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for APH1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607629

Human Genome Epidemiology Navigator: APH1A (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/38 PubMed articles for APH1A gene (see all 38 ):

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. (PubMed id 12110170)^{2, 3, 4} Francis R....Curtis D. (2002)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{2, 3, 4} Lai C.H....Lin W. (2000)
APH1, PEN2, and nicastrin increase Abeta levels and gamma-secretase activity. (PubMed id 12763021)^{1, 3, 4} Marlow L....Sambamurti K. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Reconstitution of gamma-secretase activity. (PubMed id 12679784)^{3, 4} Edbauer D.... Haass C. (2003)
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. (PubMed id 12471034)^{3, 4} Gu Y....St George-Hyslop P.H. (2003)
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. (PubMed id 12740439)^{3, 4} Kimberly W.T....Selkoe D.J. (2003)
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. (PubMed id 12522139)^{3, 4} Luo W.-J.... Xu H. (2003)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{3, 4} Clark H.F....Gray A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 51107	HGNC: 29509	AceView: APH-1A	Ensembl:ENSG00000117362	euGenes: HUgn51107
ECgene: APH1A	H-InvDB: APH1A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for APH1A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for APH1A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for APH1A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for APH1A		Antibodies for APH1A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for APH1A		Small molecules for APH1A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search OriGene for APH1A

Search Tocris compounds for APH1A

	Drugs for APH1A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for APH1A

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APH1A Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for APH1A

Summaries
for APH1A

Genomic Location
for APH1A

Proteins
for APH1A

Protein Domains/
Families
for APH1A

Gene Function
for APH1A

Pathways & Interactions
for APH1A

Drugs & Compounds
for APH1A

Transcripts
for APH1A

Expression
for APH1A

Orthologs
for APH1A

Paralogs
for APH1A

SNPs/Variants
for APH1A

Disorders & Mutations
for APH1A

Medical News
for APH1A

Publications
for APH1A

Search for APH1A

Genome Databases showing APH1A

Other Databases showing APH1A

Specialized Databases showing APH1A

Licensable Technologies
for APH1A

Services
for APH1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

APH1A Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor APH1A

Summariesfor APH1A

Genomic Locationfor APH1A

Proteinsfor APH1A

Protein Domains/Familiesfor APH1A

Gene Functionfor APH1A

Pathways & Interactionsfor APH1A

Drugs & Compoundsfor APH1A

Transcriptsfor APH1A

Expression for APH1A

Orthologsfor APH1A

Paralogsfor APH1A

SNPs/Variantsfor APH1A

Disorders & Mutationsfor APH1A

Medical Newsfor APH1A

Publicationsfor APH1A

Search for APH1A

Genome Databases showing APH1A

Other Databases showing APH1A

Specialized Databases showing APH1A

Licensable Technologiesfor APH1A

Servicesfor APH1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for APH1A

Summaries
for APH1A

Genomic Location
for APH1A

Proteins
for APH1A

Protein Domains/
Families
for APH1A

Gene Function
for APH1A

Pathways & Interactions
for APH1A

Drugs & Compounds
for APH1A

Transcripts
for APH1A

Expression
for APH1A

Orthologs
for APH1A

Paralogs
for APH1A

SNPs/Variants
for APH1A

Disorders & Mutations
for APH1A

Medical News
for APH1A

Publications
for APH1A

Licensable Technologies
for APH1A

Services
for APH1A