APEX2 Gene
protein-coding GIFtS: 60
GCID: GC0XP055043
|
|
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
| |
Aliases
for APEX2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| APEX Nuclease (Apurinic/Apyrimidinic Endonuclease) 21 2 | | DNA-(Apurinic Or Apyrimidinic Site) Lyase 22 | | APE21 2 3 5 | | EC 3.1.-.-3 | | APEXL21 2 3 5 | | EC 4.2.99.183 | | XTH21 2 3 5 | | APEX Nuclease 23 | | AP Endonuclease 22 3 | | APEX Nuclease-Like 23 | | AP Endonuclease XTH22 3 | | Apurinic-Apyrimidinic Endonuclease 23 | | Apurinic/Apyrimidinic Endonuclease-Like 22 | | |
Export aliases for APEX2 gene to outside databasesPrevious GC identifers: GC0XP051878 GC0XP052964 GC0XP053632 GC0XP053993 GC0XP054909 GC0XP052077 |
Summaries
for APEX2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for APEX2:
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents orby DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normalDNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave thephosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonucleaseactivity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This proteinmay play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcriptvariants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2012)
UniProtKB/Swiss-Prot: APEX2_HUMAN, Q9UBZ4Function: Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER)pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzinghydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strandbreak with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease,3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is ableto remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in theremoval of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BERpathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) ofimmunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes
|
Genomic Views
for APEX2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the APEX2 gene promoter:
E2F-4 E2F-3a E2F-5 RP58 E2F-1 E2F Chx10 E2F-2 POU3F2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for APEX2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APEX2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.23APEX2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP055043: view genomic region
(about GC identifiers)
Start:
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55,026,780 bp from pter |
End:
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55,035,490 bp from pter |
Size:
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8,711 bases |
Orientation:
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plus strand |
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Proteins
for APEX2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: APEX2_HUMAN, Q9UBZ4 (See
protein sequence)Recommended Name: DNA-(apurinic or apyrimidinic site) lyase 2 Size: 518 amino acids; 57401 Da
Cofactor: Magnesium. Can also utilize manganese. Probably binds two magnesium or manganese ions per subunit (Bysimilarity)
Subunit: Interacts with PCNA; this interaction is triggered by reactive oxygen species and increased bymisincorporation of uracil in nuclear DNA
Subcellular location: Nucleus. Cytoplasm. Mitochondrion (Probable). Note=Together with PCNA, is redistributed indiscrete nuclear foci in presence of oxidative DNA damaging agents
Secondary accessions: Q9Y5X7Explore the universe of human proteins at neXtProt for APEX2: NX_Q9UBZ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBZ4
APEX2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258677.1 NP_055296.2
ENSEMBL proteins: ENSP00000364126
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
APEX2 for ontologies About GeneDecksing
APEX2 Antibody Products:
Assay Products for APEX2: |
Protein
Domains /
Families
for APEX2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
APEX2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UBZ4ProtoNet protein and cluster: Q9UBZ4 1 Blocks protein family: IPB000097 AP endonuclease
UniProtKB/Swiss-Prot: APEX2_HUMAN, Q9UBZ4Similarity: Belongs to the DNA repair enzymes AP/ExoA family |
Function
for APEX2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: APEX2_HUMAN, Q9UBZ4Function: Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER)pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzinghydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strandbreak with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease,3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is ableto remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in theremoval of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BERpathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) ofimmunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytesCatalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-eliminationreaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphateEnzyme regulation: 3'-5' exonuclease activity is activated by sodium and manganese. 3'-5' exonuclease and3'-phosphodiesterase activities are stimulated in presence of PCNABiophysicochemical properties: pH dependence: Optimum pH is 6.0-8.0;Enzyme Numbers (IUBMB): EC 3.1.-.-1 EC 4.2.99.181
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APEX2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: APEX2 (NM_014481) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APEX2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APEX2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APEX2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
APEX2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Apex2tm1Yun for APEX2
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Apex2):
APEX2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for APEX2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Resolution of Abasic Sites (AP sites) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for APEX2):
APEX2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APEX2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/31 Interacting proteins for APEX2 (Q9UBZ42, 3 ENSP000003641264) via UniProtKB, MINT, STRING, and/or I2D (see all 31)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CCDC85B | Q158342, 3, ENSP000003116954 | MINT-67961 I2D:
score=5 STRING: ENSP00000311695 | | NINL | Q9Y2I62, 3, ENSP000002788864 | MINT-67835 I2D:
score=5 STRING: ENSP00000278886 | | TRIM37 | O949722, 3, ENSP000002622944 | MINT-66277 I2D:
score=5 STRING: ENSP00000262294 | | EFEMP2 | O959672, 3, ENSP000003099534 | MINT-67353 I2D:
score=4 STRING: ENSP00000309953 | | CALCOCO2 | Q131372, 3, ENSP000002589474 | MINT-68260 I2D:
score=5 STRING: ENSP00000258947 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
APEX2 for ontologies About GeneDecksing
|
Drugs & Compounds
for APEX2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for APEX2
Search CenterWatch for drugs/clinical trials and news about APEX2
|
Transcripts
for APEX2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for APEX2 gene (2 alternative transcripts): NM_001271748.1 NM_014481.3 Unigene Cluster for APEX2: APEX nuclease (apurinic/apyrimidinic endonuclease) 2 Hs.659558 [show with all ESTs]Unigene Representative Sequence: NM_0144812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374987(uc004dtz.3 uc011mom.2) ENST00000471758
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APEX2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APEX2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: APEX2 (NM_014481) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APEX2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APEX2 |
Additional cDNA sequence: AB021260.1 AB049211.1 AF119046.1 AJ011311.1 AK301555.1 AK316186.1 BC002959.1 7 DOTS entries: DT.100787510 DT.308360 DT.100787514 DT.100787505 DT.95338509 DT.100787515 DT.91669288 24/134 AceView cDNA sequences (see all 134): BQ428526 CR595088 AB021260 AF119046 BX325337 BF981813 BQ277791 NM_014481 BM795632 BQ921050 CR622468 BI333249 BE794496 CA495324 AB049211 CR617388 AI918533 AJ011311 BE076387 BC002959 CR596927 BU553240 BM541964 AI190577
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for APEX2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for APEX2
|
Expression
for APEX2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| APEX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTGAGGCC
About this image
See APEX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APEX2
SOURCE GeneReport for Unigene cluster: Hs.659558
UniProtKB/Swiss-Prot: APEX2_HUMAN, Q9UBZ4Tissue specificity: Highly expressed in brain and kidney. Weakly expressed in the fetal brain
SABiosciences Expression via Pathway-Focused PCR Array including APEX2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APEX2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APEX2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APEX2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APEX2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APEX2 |
Orthologs
for APEX2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for APEX2 gene from 5/22 species (see all 22) About this table
ENSEMBL Gene Tree for APEX2 (if available)
TreeFam Gene Tree for APEX2 (if available) |
Paralogs
for APEX2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for APEX2 gene
- APEX12
APEX2 for paralogs About GeneDecksing
|
Genomic Variants
for APEX2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for APEX2 (55026780 - 55035490 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for APEX2
1 CNV: 23256
Locus Specific Mutation Databases (LSDB): APEX2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APEX2 |
|
Disorders
/ Diseases
for APEX2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
APEX2 for disorders About GeneDecksing
OMIM gene information: 300773
OMIM disorders: --
5  diseases for APEX2: About MalaCardsmultiple sclerosis schizophrenia tuberculosis malaria
mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: APEX2 (1 document)
Export disorders for APEX2 gene to outside databases
|
Publications
for APEX2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for APEX2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with APEX2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen. (PubMed id 11376153)1, 2, 3, 9 Tsuchimoto D.... Nakabeppu Y. (2001)
- Role of PCNA-dependent stimulation of 3'-phosphodiest erase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage. (PubMed id 19443450)1, 2, 9 Burkovics P....Haracska L. (2009)
- Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs. (PubMed id 16687656)1, 2, 9 Burkovics P....Haracska L. (2006)
- Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing. (PubMed id 20843780)1, 2 Wang W....Scharfe C. (2010)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. (PubMed id 11866537)1, 9 Hadi M.Z....Wilson D.M. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for APEX2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing APEX2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing APEX2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing APEX2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for APEX2 gene:
Search GeneIP for patents involving APEX2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for APEX2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for APEX2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APEX2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APEX2 | | | OriGene Protein Over-expression Lysate for APEX2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for APEX2 | | OriGene 3'-UTR Clone for APEX2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APEX2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APEX2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for APEX2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for APEX2 | | OriGene Custom Protein Services for APEX2 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APEX2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APEX2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APEX2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APEX2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APEX2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APEX2 |
| |
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| | | | Search Tocris compounds for APEX2 |
| |  |  |  |  | | | | |
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 | | | APEX2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APEX2 |
|  |  |  | | | | ThermoFisher Antibodies for APEX2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APEX2 |
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