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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APEX1 Gene

protein-coding   GIFtS: 70
GCID: GC14P020924

APEX Nuclease (Multifunctional DNA Repair Enzyme) 1

(Previous name: APEX nuclease (multifunctional DNA repair enzyme))
(Previous symbol: APEX)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
APEX Nuclease (Multifunctional DNA Repair Enzyme) 11 2     AP Endonuclease Class I2
APEX1 2 3 5     AP Lyase2
APE2 3 5     Apurinic/Apyrimidinic (Abasic) Endonuclease2
Apurinic-Apyrimidinic Endonuclease 12 3     Deoxyribonuclease (Apurinic Or Apyrimidinic)2
Redox Factor-12 3     DNA-(Apurinic Or Apyrimidinic Site) Lyase2
APE12 3     Protein REF-12
APEN2 3     APE-13
APX2 3     EC 3.1.-.-3
HAP12 3     REF-13
REF12 3     AP Endonuclease 13
EC 4.2.99.183 8     APEX Nuclease3
APEX Nuclease (Multifunctional DNA Repair Enzyme)1     

External Ids:    HGNC: 5871   Entrez Gene: 3282   Ensembl: ENSG000001008237   OMIM: 1077485   UniProtKB: P276953   

Export aliases for APEX1 gene to outside databases

Previous GC identifers: GC14P018294 GC14P014710 GC14P018913 GC14P019993 GC14P001044


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APEX1 Gene:
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging
agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can
prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP
endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease
in human cells. Splice variants have been found for this gene; all encode the same protein. (provided by RefSeq,
Jul 2008)

GeneCards Summary for APEX1 Gene: 
APEX1 (APEX nuclease (multifunctional DNA repair enzyme) 1) is a protein-coding gene. Diseases associated with APEX1 include cheilitis, and actinic cheilitis, and among its related super-pathways are Removal of DNA patch containing abasic residue and Base-free sugar-phosphate removal via the single-nucleotide replacement pathway. GO annotations related to this gene include RNA binding and transcription corepressor activity. An important paralog of this gene is APEX2.

UniProtKB/Swiss-Prot: APEX1_HUMAN, P27695
Function: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two
major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a
apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions
induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision
of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with
5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids,
single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease
activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during
short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as
phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of
gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP
sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a
role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA
cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox
activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling
the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in
calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response
elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator
of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and
Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded
RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA
dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA
quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter.
Together with NPM1, associates with rRNA. Binds DNA and RNA

Gene Wiki entry for APEX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APEX1 gene promoter:
         GR   AP-1   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): APEX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for APEX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APEX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

APEX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APEX1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P020924:  view genomic region     (about GC identifiers)

Start:
20,923,290 bp from pter      End:
20,925,927 bp from pter
Size:
2,638 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APEX1_HUMAN, P27695 (See protein sequence)
Recommended Name: DNA-(apurinic or apyrimidinic site) lyase  
Size: 318 amino acids; 35555 Da
Cofactor: Magnesium. Can also utilize manganese. Probably binds two magnesium or manganese ions per subunit
Subunit: Monomer. Homodimer; disulfide-linked. Component of the SET complex, composed at least of APEX1, GZMA,
SET, ANP32A, HMGB2 and NME1. Associates with the dimer XRCC5/XRCC6 in a DNA-dependent manner. Interacts with
SIRT1; the interaction is increased in the context of genotoxic stress. Interacts with HDAC1, HDAC2 and HDAC3;
the interactions are not dependent on the APEX1 acetylation status. Interacts with XRCC1; the interaction is
induced by SIRT1 and increased with the APEX1 acetylated form. Interacts with NPM1 (via N-terminal domain); the
interaction is RNA-dependent and decreases in hydrogen peroxide-damaged cells. Interacts (via N-terminus) with
YBX1 (via C-terminus); the interaction is increased in presence of APEX1 acetylated at Lys-6 and Lys-7. Interacts
with HNRNPL; the interaction is DNA-dependent. Interacts (via N-terminus) with KPNA1 and KPNA2. Interacts with
TXN; the interaction stimulates the FOS/JUN AP-1 complex DNA-binding activity in a redox-dependent manner.
Interacts with GZMA, KRT8, MDM2, POLB, PRDX6, PRPF19, RPLP0, TOMM20 and WDR77. Binds to CDK5 (By similarity)
Subcellular location: Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm.
Note=Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the
nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to
nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar
localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the
endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide
(NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal
(amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling.
Ubiquitinated form is localized predominantly in the cytoplasm
Subcellular location: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion. Note=The cleaved
APEX2 is only detected in mitochondria (By similarity). Translocation from the cytoplasm to the mitochondria is
mediated by ROS signaling and cleavage mediated by granzyme A. Tom20-dependent translocated mitochondrial APEX1
level is significantly increased after genotoxic stress
Miscellaneous: Extract of mitochondria, but not of nuclei or cytosol, cleaves recombinant APEX1 to generate a
mitochondrial APEX1-sized product (By similarity). The specific activity of the cleaved mitochondrial
endodeoxyribonuclease appeared to be about 3-fold higher than that of the full-length form
6/12 PDB 3D structures from and Proteopedia for APEX1 (see all 12):
1BIX (3D)        1CQG (3D)        1CQH (3D)        1DE8 (3D)        1DE9 (3D)        1DEW (3D)    
Secondary accessions: Q969L5 Q99775

Explore the universe of human proteins at neXtProt for APEX1: NX_P27695

Explore proteomics data for APEX1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation by kinase PKC or casein kinase CK2 results in enhanced redox activity that
    stimulates binding of the FOS/JUN AP-1 complex to its cognate binding site. AP-endodeoxyribonuclease activity is
    not affected by CK2-mediated phosphorylation. Phosphorylation of Thr-233 by CDK5 reduces AP-endodeoxyribonuclease
    activity resulting in accumulation of DNA damage and contributing to neuronal death
  • UniProtKB: Acetylated on Lys-6 and Lys-7. Acetylation is increased by the transcriptional coactivator EP300
    acetyltransferase, genotoxic agents like H(2)O(2) and methyl methanesulfonate (MMS). Acetylation increases its
    binding affinity to the negative calcium response element (nCaRE) DNA promoter. The acetylated form induces a
    stronger binding of YBX1 to the Y-box sequence in the MDR1 promoter than the unacetylated form. Deacetylated on
    lysines. Lys-6 and Lys-7 are deacetylated by SIRT1
  • UniProtKB: Cleaved at Lys-31 by granzyme A to create the mitochondrial form; leading in reduction of binding to DNA, AP
    endodeoxynuclease activity, redox activation of transcription factors and to enhanced cell death. Cleaved by
    granzyme K; leading to intracellular ROS accumulation and enhanced cell death after oxidative stress
  • UniProtKB: Cys-65 and Cys-93 are nitrosylated in response to nitric oxide (NO) and lead to the exposure of the nuclear export
    signal (NES)
  • UniProtKB: Ubiquitinated by MDM2; leading to translocation to the cytoplasm and proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27695

  • 4/6 DME Specific Peptides for APEX1 (P27695) (see all 6)
     NVGWRLDY  AYTFWTYM  LKICSWNV  DSFRHLYPNT 

    APEX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APEX1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001231178.1  NP_001632.2  NP_542379.1  NP_542380.1  

    ENSEMBL proteins: 
     ENSP00000451979   ENSP00000216714   ENSP00000451327   ENSP00000452137   ENSP00000381111  
     ENSP00000450604   ENSP00000452304   ENSP00000452460   ENSP00000451491   ENSP00000451170  
     ENSP00000452212   ENSP00000451060   ENSP00000452418   ENSP00000416414  
    Reactome Protein details: P27695
    Human Recombinant Protein Products for APEX1: 
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    Enzo Life Sciences proteins for APEX1
    OriGene Purified Proteins for APEX1
    OriGene Protein Over-expression Lysate for APEX1
    OriGene MassSpec for APEX1 
    OriGene Custom Protein Services for APEX1
    GenScript Custom Purified and Recombinant Proteins Services for APEX1
    Novus Biologicals APEX1 Proteins
    Novus Biologicals APEX1 Lysates
    Sino Biological Recombinant Protein for APEX1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for APEX1
    Cloud-Clone Corp. Proteins for APEX1 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005730nucleolus IDA17148573

    APEX1 for ontologies           About GeneDecksing



    APEX1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for APEX1 (APE)
    Cell Signaling Technology (CST) Antibodies for APEX1  (APE1)
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    OriGene Custom Antibody Services for APEX1
    GenScript Superior Antibodies for APEX1
    Novus Biologicals APEX1 Antibodies
    Abcam antibodies for APEX1
    Cloud-Clone Corp. Antibodies for APEX1 
    ThermoFisher Antibody for APEX1
    LSBio Antibodies in human, mouse, rat for APEX1 

    Assay Products for APEX1: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for APEX1 (APE)
    GenScript Custom Assay Services for APEX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for APEX1 
    Cloud-Clone Corp. CLIAs for APEX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR020848 AP_endonuclease_F1_CS
     IPR020847 AP_endonuclease_F1_BS
     IPR005135 Endo/exonuclease/phosphatase
     IPR004808 ExoDNase_III

    Graphical View of Domain Structure for InterPro Entry P27695

    ProtoNet protein and cluster: P27695

    1 Blocks protein domain: IPB000097 AP endonuclease

    UniProtKB/Swiss-Prot: APEX1_HUMAN, P27695
    Domain: The N-terminus contains the redox activity while the C-terminus exerts the DNA AP-endodeoxyribonuclease
    activity; both function are independent in their actions. An unconventional mitochondrial targeting sequence
    (MTS) is harbored within the C-terminus, that appears to be masked by the N-terminal sequence containing the
    nuclear localization signal (NLS), that probably blocks the interaction between the MTS and Tom proteins
    Similarity: Belongs to the DNA repair enzymes AP/ExoA family


    APEX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APEX1_HUMAN, P27695
    Function: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two
    major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a
    apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions
    induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision
    of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with
    5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids,
    single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease
    activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during
    short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as
    phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of
    gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP
    sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a
    role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA
    cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox
    activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling
    the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in
    calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response
    elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator
    of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and
    Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded
    RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA
    dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA
    quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter.
    Together with NPM1, associates with rRNA. Binds DNA and RNA
    Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination
    reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
    Enzyme regulation: NPM1 stimulates endodeoxyribonuclease activity on double-stranded DNA with AP sites, but
    inhibits endoribonuclease activity on single-stranded RNA containing AP sites
    Induction: Up-regulated in presence of reactive oxygen species (ROS), like bleomycin, H(2)O(2) and phenazine
    methosulfate

         Enzyme Numbers (IUBMB): EC 4.2.99.181 2 EC 3.1.-.-1

         Gene Ontology (GO): 5/22 molecular function terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA11286553
    GO:0003684damaged DNA binding IDA12524539
    GO:0003713transcription coactivator activity IDA9119221
    GO:0003714transcription corepressor activity TAS7961715
    GO:0003723RNA binding IEA--
         
    APEX1 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Apex1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     normal  reproductive system  tumorigenesis 

    APEX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for APEX1: Apex1tm1Cur Apex1tm1Djc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for APEX1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APEX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APEX1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APEX1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APEX1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate APEX1
    SwitchGear 3'UTR luciferase reporter plasmidAPEX1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for APEX1
    Sirion Biotech Customized adenovirus for overexpression of APEX1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for APEX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): APEX1 (NM_001641)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APEX1
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                         Customized lentivirus expression plasmids for stable overexpression of APEX1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APEX1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APEX1 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Removal of DNA patch containing abasic residue0.89
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    Base excision repair0.53
    Base Excision Repair0.89
    2Base-Excision Repair, AP Site Formation
    Base-free sugar-phosphate removal via the single-nucleotide replacement pathway0.90
    Resolution of AP sites via the single-nucleotide replacement pathway0.83
    Displacement of DNA glycosylase by APE10.90
    3DNA Damage
    DNA Damage0.32
    Cell Cycle / Checkpoint Control0.32
    4Transcription P53 signaling pathway
    Transcription P53 signaling pathway0.98
    5Nucleotide Excision Repair
    DNA Repair0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for APEX1
        Transcription P53 signaling pathway

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for APEX1
        Granzyme-A Pathway
    DNA Repair Mechanisms
    HIF1Alpha Pathway
    Granzyme Pathway

    4 Cell Signaling Technology (CST) Pathways for APEX1
        Cell Cycle / Checkpoint Control
    Neuroscience
    Lymphocyte Signaling
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for APEX1
        Transcription P53 signaling pathway

    3 BioSystems Pathways for APEX1
        Spinal Cord Injury
    TSH signaling pathway
    HIF-2-alpha transcription factor network


    5/8        Reactome Pathways for APEX1 (see all 8)
        Removal of DNA patch containing abasic residue
    DNA Repair
    Displacement of DNA glycosylase by APE1
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway
    Base Excision Repair

    1 PharmGKB Pathway for APEX1
        Busulfan Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for APEX1):
        Base excision repair


    APEX1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APEX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/99 Interacting proteins for APEX1 (P276951, 2, 3 ENSP000002167144) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232804P081072, 3, ENSP000003930874MINT-16427 MINT-16428 MINT-8076071 I2D: score=3 STRING: ENSP00000393087
    ENSG00000212866P081072, 3MINT-16427 MINT-16428 MINT-8076071 I2D: score=3 
    ENSG00000215328P081072, 3MINT-16427 MINT-16428 MINT-8076071 I2D: score=3 
    ENSG00000224501P081072, 3MINT-16427 MINT-16428 MINT-8076071 I2D: score=3 
    ENSG00000231555P081072, 3MINT-16427 MINT-16428 MINT-8076071 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006284base-excision repair TAS--
    GO:0006310DNA recombination IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    APEX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APEX1 for compounds           About GeneDecksing

    EMD Millipore small molecules for APEX1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APEX1

    1 HMDB Compound for APEX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for APEX1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lucanthone1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one (see all 7)479-50-5targetinhibitor15330152

    10/95 Novoseek inferred chemical compound relationships for APEX1 gene (see all 95)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    8-oxoguanine 77.5 10 11937636 (1), 16051529 (1), 18685817 (1), 15541770 (1) (see all 9)
    methylmethanesulfonate 72.7 9 15210853 (1), 15330152 (1), 1627644 (1), 18776186 (1) (see all 7)
    deoxyribose-5-phosphate 67.6 1 9207062 (1)
    troxacitabine 67.6 1 19470598 (1)
    3,n(4)-ethenocytosine 67.2 2 11506820 (1), 12161446 (1)
    phosphoglycolate 66.7 2 7516064 (1), 9171104 (1)
    fibrinolysin 65.2 8 11937475 (5), 9239167 (2), 1973756 (1)
    lucanthone 63.7 9 15330152 (6), 12449731 (1)
    phosphodiester 62.8 18 20073480 (1), 11356334 (1), 11554453 (1), 9870152 (1) (see all 13)
    2-deoxyribonolactone 62 3 16623699 (1), 16199212 (1)

    Search CenterWatch for drugs/clinical trials and news about APEX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APEX1 gene (4 alternative transcripts): 
    NM_001244249.1  NM_001641.3  NM_080648.2  NM_080649.2  

    Unigene Cluster for APEX1:

    APEX nuclease (multifunctional DNA repair enzyme) 1
    Hs.73722  [show with all ESTs]
    Unigene Representative Sequence: NM_001641
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000555414(uc001vxh.3 uc001vxi.3) ENST00000216714(uc001vxg.3 uc021rnr.1)
    ENST00000553681 ENST00000554813 ENST00000556296 ENST00000557344 ENST00000555306
    ENST00000553555 ENST00000398030 ENST00000554325 ENST00000557181 ENST00000555839
    ENST00000557159 ENST00000553368 ENST00000556054 ENST00000557054 ENST00000557592
    ENST00000557365
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    OriGene clones in human, mouse for APEX1 (see all 20)
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                         Customized lentivirus expression plasmids for stable overexpression of APEX1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APEX1
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    Additional mRNA sequence: 

    AK098588.1 AK291100.1 AK311548.1 BC002338.2 BC004979.1 BC008145.1 BC019291.1 BC095428.1 
    BT007236.1 BT020133.1 BX161454.1 D90373.1 M80261.1 M81955.1 S43127.1 U79268.1 
    X59764.1 

    24/40 DOTS entries (see all 40):

    DT.450716  DT.91865427  DT.97860983  DT.95340211  DT.97860985  DT.100045339  DT.100840911  DT.100892357 
    DT.120732604  DT.100892368  DT.117122  DT.100892372  DT.92466528  DT.102837774  DT.100892382  DT.100892402 
    DT.120732702  DT.100892406  DT.100763085  DT.95310093  DT.120733139  DT.100807403  DT.100808976  DT.100892365 

    24/942 AceView cDNA sequences (see all 942):

    CR613058 BQ935833 AW574574 CB127545 CR611116 BM830202 BM450434 BM888449 
    AI675595 BI222572 BE464614 CA309181 BU189191 M81955 AI061348 BX457931 
    BQ364641 BX408673 BE790692 AU156659 BM974555 BM459182 BX408108 CB215946 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for APEX1 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ·
    SP1:                                                        -     -     -     -     -           -     -                                                         
    SP2:                          -     -     -     -     -     -     -     -     -     -           -     -                                                         
    SP3:                                                              -     -     -     -           -     -                                                         
    SP4:                                                              -     -     -     -           -     -                                         -               
    SP5:                                                  -     -     -     -     -     -           -     -                                                         

    ExUns: 9c · 9d · 9e · 9f · 9g · 9h
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for APEX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APEX1 expression in normal human tissues (normalized intensities)      APEX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATAAAGA
    APEX1 Expression
    About this image


    APEX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/41 selected tissues (see all 41) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Nose (Sensory Organs)    fully expand to see all 5 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/naso-lacrimal duct   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See APEX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APEX1

    SOURCE GeneReport for Unigene cluster: Hs.73722
        SABiosciences Expression via Pathway-Focused PCR Arrays including APEX1 (see all 7): 
              HIV Host Response in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APEX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for APEX1 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apex11 , 5 apurinic/apyrimidinic endonuclease 11, 5 86.65(n)1
    94.64(a)1
      14 (26.30 cM)5
    117921  NM_009687.21  NP_033817.11 
     509249685 
    chicken
    (Gallus gallus)
    Aves APEX11 APEX nuclease (multifunctional DNA repair enzyme) 1 60.22(n)
    63(a)
      100431102  NM_001184759.1  NP_001171688.1 
    lizard
    (Anolis carolinensis)
    Reptilia APEX16
    Uncharacterized protein
    70(a)
    1 ↔ 1
    GL343220.1(1204334-1212440)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247952 Xenopus laevis transcribed sequence with weak similarity more 72.36(n)    CF548074.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzehn15322 Danio rerio cDNA clone MGC66204 IMAGE5914323, complete more 72.86(n)    BC055545.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rrp11 Recombination repair protein 1 55(n)
    53.33(a)
      33500  NM_057493.3  NP_476841.1 
    worm
    (Caenorhabditis elegans)
    Secernentea exo-31 Protein EXO-3 51.2(n)
    46.4(a)
      173069  NM_001026413.2  NP_001021584.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APN26
    Class II abasic (AP) endonuclease involved in repa...
    14(a)
    1 → many
    II(184353-185915)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARP1 apurinic endonuclease-redox protein 48.88(n)
    46.31(a)
      818744  NM_129709.4  NP_181677.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g08010001 hypothetical protein 49.78(n)
    44.19(a)
      4327960  NM_001051072.1  NP_001044537.1 


    ENSEMBL Gene Tree for APEX1 (if available)
    TreeFam Gene Tree for APEX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APEX1 gene
    APEX22  

    APEX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/164 SNPs in APEX1 are shown (see all 164)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829394541,2
    C--1042925(+) CAGCTC/TAATCA 4 -- us2k10--------
    rs1874786081,2
    --1920400(+) AAGCAC/TTGAGT 4 -- us2k10--------
    rs1390125591,2
    --1920554(+) CTATGC/TATGCA 4 -- us2k10--------
    rs114759211,2
    C--1920634(+) TTGTAC/-TTTTT 4 -- us2k1 trp31Minor allele frequency- -:0.50CSA 2
    rs777949161,2
    C,F--1920634(+) TTGTAC/TTTTTT 4 -- us2k12Minor allele frequency- T:0.50WA NA 4
    rs1920906801,2
    C--1920859(+) AACCCC/TGACCT 4 -- us2k10--------
    rs1123560311,2
    C--1920925(+) CCACGC/TCCAGC 4 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs761414901,2
    --1920930(+) CCCAGA/CCGTGT 4 -- us2k10--------
    rs1161461171,2
    C,F--1920968(+) CTAATG/AATACA 4 -- us2k12Minor allele frequency- A:0.09WA EA 238
    rs1841924531,2
    --1921012(+) CCCGAC/GCGGTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for APEX1 (20923290 - 20925927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for APEX1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv23438CNV Gain+Loss19812545


    Human Gene Mutation Database (HGMD): APEX1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107748    OMIM disorders: --

    20/94 diseases for APEX1 (see all 94):    About MalaCards
    cheilitis    actinic cheilitis    attenuated familial adenomatous polyposis    pleuropneumonia
    bladder cancer susceptibility    cystic fibrosis    acoustic neuroma    neuroma
    smooth muscle tumor    diphtheria    biliary tract cancer    familial adenomatous polyposis
    differentiating neuroblastoma    pterygium    orofacial cleft    inclusion body myositis
    bronchiolitis    bronchitis    xeroderma pigmentosum    myositis


    APEX1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/55 Novoseek inferred disease relationships for APEX1 gene (see all 55)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 65.1 56 10796748 (4), 20298317 (3), 7800431 (2), 12917899 (2) (see all 39)
    atelectasis 39.6 7 20298317 (2), 19489944 (2), 11716180 (1)
    lung diseases 34.3 8 12023366 (2), 12917899 (1), 8680379 (1), 16236891 (1) (see all 7)
    cancer 29.3 41 18627350 (4), 20087352 (3), 19072053 (2), 11316543 (2) (see all 17)
    tumors 12.9 58 18809583 (3), 18535621 (3), 16823850 (2), 11420300 (2) (see all 31)
    xeroderma pigmentosum 12.9 2 7775413 (1), 18946634 (1)
    amyotrophic lateral sclerosis 11.8 3 9507962 (1), 18482781 (1)
    diphtheria 9.11 4 2109323 (1), 9783263 (1), 15680246 (1), 2318891 (1)
    bronchiolitis 7.89 3 17356094 (2), 11716180 (1)
    cancer lung 7.51 13 19124501 (5), 19528510 (4), 15333465 (2), 18809583 (1) (see all 5)

    Genetic Association Database (GAD): APEX1
    Human Genome Epidemiology (HuGE) Navigator: APEX1 (127 documents)

    Export disorders for APEX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APEX1 gene, integrated from 9 sources (see all 730):
    (articles sorted by number of sources associating them with APEX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III. (PubMed id 1627644)1, 2, 9 Seki S.... Tsutsui K. (1992)
    2. Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision. (PubMed id 18439621)1, 2, 9 Berquist B.R....Wilson D.M. (2008)
    3. Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma. (PubMed id 16621887)1, 4, 9 Li C....Wei Q. (2006)
    4. Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. (PubMed id 11809897)1, 2, 9 Kuninger D.T....Mitra S. (2002)
    5. Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA. (PubMed id 19401441)1, 2, 9 Barnes T....Lee C.H. (2009)
    6. A polymorphism in the APE1 gene promoter is associated with lung cancer risk. (PubMed id 19124501)1, 4, 9 Lo Y.L....Hsiung C.A. (2009)
    7. Apurinic/apyrimidinic endonuclease (APE1) gene polymo rphisms and lung cancer risk in relation to tobacco smoking. (PubMed id 19528510)1, 4, 9 AgaAshan B....Isbir T. (2009)
    8. DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination. (PubMed id 10667800)1, 2, 9 Mol C.D.... Tainer J.A. (2000)
    9. Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation. (PubMed id 11118054)1, 2, 9 Wei S.J....Gius D. (2000)
    10. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. (PubMed id 9108029)1, 2, 9 Hirota K....Yodoi J. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 328 HGNC: 587 AceView: APEX1 Ensembl:ENSG00000100823 euGenes: HUgn328
    ECgene: APEX1 Kegg: 328 H-InvDB: APEX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APEX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APEX1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/apex/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APEX1 gene:
    Search GeneIP for patents involving APEX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Proteins for APEX1
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     ThermoFisher Antibody for APEX1
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for APEX1
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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