Aliases for APELA Gene
External Ids for APELA Gene
Previous GeneCards Identifiers for APELA Gene
This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/AKT pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. [provided by RefSeq, Jul 2016]
GeneCards Summary for APELA Gene
APELA (Apelin Receptor Early Endogenous Ligand) is a Protein Coding gene. GO annotations related to this gene include hormone activity and apelin receptor binding.
UniProtKB/Swiss-Prot for APELA Gene
Hormone required during early development for endoderm differentiation and heart morphogenesis by acting as a ligand for the apelin receptor (APLNR). Acts as a motogen by promoting endoderm and mesendoderm cell migration during gastrulation by binding and activating the apelin receptor, thereby driving internalization of the apelin receptor. Plays a key role during heart development by acting as a ligand for the apelin receptor (By similarity).