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Aliases for APEH Gene

Aliases for APEH Gene

  • Acylaminoacyl-Peptide Hydrolase 2 3 5
  • Acylaminoacyl-Peptidase 2 3 4
  • N-Acylaminoacyl-Peptide Hydrolase 2 3
  • Oxidized Protein Hydrolase 3 4
  • Acyl-Peptide Hydrolase 3 4
  • EC 3.4.19.1 4 63
  • D3F15S2 3 4
  • DNF15S2 3 4
  • D3S48E 3 4
  • AARE 3 4
  • APH 3 4
  • OPH 3 4
  • Acylamino-Acid-Releasing Enzyme 2
  • ACPH 3

External Ids for APEH Gene

Previous HGNC Symbols for APEH Gene

  • D3F15S2
  • DNF15S2
  • D3S48E

Previous GeneCards Identifiers for APEH Gene

  • GC03U990008
  • GC03M048683
  • GC03P049565
  • GC03P049670
  • GC03P049686
  • GC03P049711

Summaries for APEH Gene

Entrez Gene Summary for APEH Gene

  • This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for APEH Gene

APEH (Acylaminoacyl-Peptide Hydrolase) is a Protein Coding gene. Diseases associated with APEH include renal cell carcinoma and barbiturate dependence. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and serine-type endopeptidase activity.

UniProtKB/Swiss-Prot for APEH Gene

  • This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

Gene Wiki entry for APEH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APEH Gene

Genomics for APEH Gene

Regulatory Elements for APEH Gene

Promoters for APEH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APEH on UCSC Golden Path with GeneCards custom track

Genomic Location for APEH Gene

Chromosome:
3
Start:
49,673,130 bp from pter
End:
49,683,963 bp from pter
Size:
10,834 bases
Orientation:
Plus strand

Genomic View for APEH Gene

Genes around APEH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APEH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APEH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APEH Gene

Proteins for APEH Gene

  • Protein details for APEH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13798-ACPH_HUMAN
    Recommended name:
    Acylamino-acid-releasing enzyme
    Protein Accession:
    P13798
    Secondary Accessions:
    • Q9BQ33
    • Q9P0Y2

    Protein attributes for APEH Gene

    Size:
    732 amino acids
    Molecular mass:
    81225 Da
    Quaternary structure:
    • Homotetramer.
    SequenceCaution:
    • Sequence=AAA35769.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for APEH Gene

Proteomics data for APEH Gene at MOPED

Post-translational modifications for APEH Gene

  • Ubiquitination at Lys 131, Lys 180, Lys 291, Lys 443, Lys 664, Lys 681, and Lys 704
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for APEH Gene

Suggested Antigen Peptide Sequences for APEH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13798

UniProtKB/Swiss-Prot:

ACPH_HUMAN :
  • Belongs to the peptidase S9C family.
Family:
  • Belongs to the peptidase S9C family.
genes like me logo Genes that share domains with APEH: view

No data available for Gene Families for APEH Gene

Function for APEH Gene

Molecular function for APEH Gene

GENATLAS Biochemistry:
N-acylaminoacyl-peptide hydrolase,with reduced expression in renal cell carcinoma (see D3F15S2,D3S94,TSG3C),highly homolog to the tightly linked MST1 gene
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.
UniProtKB/Swiss-Prot Function:
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.

Enzyme Numbers (IUBMB) for APEH Gene

Gene Ontology (GO) - Molecular Function for APEH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008242 omega peptidase activity IDA 17241160
genes like me logo Genes that share ontologies with APEH: view
genes like me logo Genes that share phenotypes with APEH: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APEH Gene

Localization for APEH Gene

Subcellular locations from UniProtKB/Swiss-Prot for APEH Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APEH Gene COMPARTMENTS Subcellular localization image for APEH gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
lysosome 2
plasma membrane 2
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for APEH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with APEH: view

Pathways & Interactions for APEH Gene

genes like me logo Genes that share pathways with APEH: view

Pathways by source for APEH Gene

Gene Ontology (GO) - Biological Process for APEH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with APEH: view

No data available for SIGNOR curated interactions for APEH Gene

Drugs & Compounds for APEH Gene

(5) Drugs for APEH Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for APEH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APEH: view

Transcripts for APEH Gene

Unigene Clusters for APEH Gene

N-acylaminoacyl-peptide hydrolase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APEH Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1: - -
SP2: - - - -
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9: - - - -

ExUns: 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for APEH Gene

GeneLoc Exon Structure for
APEH
ECgene alternative splicing isoforms for
APEH

Expression for APEH Gene

mRNA expression in normal human tissues for APEH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for APEH Gene

This gene is overexpressed in Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for APEH Gene



SOURCE GeneReport for Unigene cluster for APEH Gene Hs.517969

genes like me logo Genes that share expression patterns with APEH: view

Protein tissue co-expression partners for APEH Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for APEH Gene

Orthologs for APEH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for APEH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APEH 35
  • 90.49 (n)
  • 90.95 (a)
APEH 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APEH 35
  • 91.8 (n)
  • 93.85 (a)
APEH 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apeh 35
  • 89.16 (n)
  • 91.39 (a)
Apeh 16
Apeh 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APEH 35
  • 99.86 (n)
  • 99.86 (a)
APEH 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apeh 35
  • 88.93 (n)
  • 92.21 (a)
oppossum
(Monodelphis domestica)
Mammalia APEH 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APEH 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves APEH 35
  • 70.33 (n)
  • 66.07 (a)
APEH 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APEH 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apeh 35
  • 64.77 (n)
  • 65.37 (a)
Str.7036 35
zebrafish
(Danio rerio)
Actinopterygii apeh 35
  • 61.92 (n)
  • 61.27 (a)
apeh 36
  • 60 (a)
OneToMany
APEH (2 of 4) 36
  • 49 (a)
OneToMany
APEH (3 of 4) 36
  • 62 (a)
OneToMany
CABZ01074181.1 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R11E3.8 37
  • 33 (a)
dpf-5 35
  • 45.87 (n)
  • 35.73 (a)
dpf-4 36
  • 18 (a)
OneToMany
dpf-5 36
  • 33 (a)
OneToMany
dpf-6 36
  • 15 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G14570 35
  • 45.25 (n)
  • 36.08 (a)
rice
(Oryza sativa)
Liliopsida Os10g0415800 35
  • 44.68 (n)
  • 36.97 (a)
Species with no ortholog for APEH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APEH Gene

ENSEMBL:
Gene Tree for APEH (if available)
TreeFam:
Gene Tree for APEH (if available)

Paralogs for APEH Gene

No data available for Paralogs for APEH Gene

Variants for APEH Gene

Sequence variations from dbSNP and Humsavar for APEH Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3816877 - 49,682,366(-) AGCCC(A/G)TGGAG reference, missense
rs1131095 -- 49,676,792(+) TATTA(C/T)GTGGA reference, synonymous-codon
rs3834791 -- 49,673,805(-) AGCGT(-/GAGCGTGAGCGT)GAGGG intron-variant, upstream-variant-2KB, cds-indel
rs3762650 -- 49,673,801(-) GTGAG(C/G)GTGAG intron-variant, upstream-variant-2KB, reference, missense
rs3172215 -- 49,683,431(+) GCTTT(C/T)TGGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for APEH Gene

Variant ID Type Subtype PubMed ID
nsv508217 CNV Loss 20534489
nsv820990 CNV Duplication 20802225
esv28815 CNV Gain+Loss 19812545

Variation tolerance for APEH Gene

Residual Variation Intolerance Score: 9.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APEH Gene

HapMap Linkage Disequilibrium report
APEH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APEH Gene

Disorders for APEH Gene

MalaCards: The human disease database

(4) MalaCards diseases for APEH Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
barbiturate dependence
rubeosis iridis
peliosis hepatis
  • hepatic peliosis
- elite association - COSMIC cancer census association via MalaCards
Search APEH in MalaCards View complete list of genes associated with diseases

Relevant External Links for APEH

Genetic Association Database (GAD)
APEH
Human Genome Epidemiology (HuGE) Navigator
APEH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APEH
genes like me logo Genes that share disorders with APEH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APEH Gene

Publications for APEH Gene

  1. Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase. (PMID: 10719179) Fujino T. … Yasuda H. (Biochim. Biophys. Acta 2000) 3 4 23 67
  2. Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide. (PMID: 17241160) Yamin R. … Abraham C.R. (J. Neurochem. 2007) 3 23
  3. Functional proteomics using microchannel plate detectors. (PMID: 11921441) Richards P. … Lees J. (Proteomics 2002) 3 23
  4. The nucleotide sequence of human acylamino acid-releasing enzyme. (PMID: 8724851) Mitta M. … Tsunasawa S. (DNA Res. 1996) 3 23
  5. Crystallization and preliminary X-ray studies of human erythrocyte acylpeptide hydrolase. (PMID: 8411161) Feese M. … Remington S.J. (J. Mol. Biol. 1993) 3 23

Products for APEH Gene

Sources for APEH Gene

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