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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APEH Gene

protein-coding   GIFtS: 60
GCID: GC03P049711

N-acylaminoacyl-peptide hydrolase


(Previous symbols: D3F15S2, DNF15S2, D3S48E)
 Explore 27 diseases affiliated with
APEH via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for APEH    

Aliases
for APEH gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
N-Acylaminoacyl-Peptide Hydrolase1 2     APH2 3
D3S48E1 2 3 5     OPH2 3
D3F15S21 2 3     EC 3.4.19.13 8
DNF15S21 2 3     ACPH2
Acyl-Peptide Hydrolase2 3     Acylamino-Acid-Releasing Enzyme2
Oxidized Protein Hydrolase2 3     Acylaminoacyl-Peptidase1
AARE2 3     Acylaminoacyl-Peptidase1

External Ids:    HGNC: 5861   Entrez Gene: 3272   Ensembl: ENSG000001640627   OMIM: 1026455   UniProtKB: P137983   

Export aliases for APEH gene to outside databases

Previous GC identifers: GC03U990008 GC03M048683 GC03P049565 GC03P049670 GC03P049686


Summaries
for APEH gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for APEH:
This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino
acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further
processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of
chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in
aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting
of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells.
Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal
cell carcinoma. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ACPH_HUMAN, P13798
Function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an
N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser

Gene Wiki entry for APEH


Genomic Views
for APEH gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APEH gene promoter:
         SREBP-1c   CUTL1   LCR-F1   SREBP-1b   Max   FOXI1   SREBP-1a   SEF-1 (1)   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APEH promoter sequence
   Search SABiosciences Chromatin IP Primers for APEH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APEH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

APEH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APEH gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P049711:  view genomic region     (about GC identifiers)

Start:
 49,711,435 bp from pter      End:
 49,721,396 bp from pter
Size:
 9,962 bases      Orientation:
 plus strand

Proteins
for APEH gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACPH_HUMAN, P13798 (See protein sequence)
Recommended Name: Acylamino-acid-releasing enzyme  
Size: 732 amino acids; 81225 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
Mass spectrometry: Mass=81269.9; Mass_error=8.7; Method=Electrospray; Range=1-732; Source=PubMed:10395453;
Sequence caution: Sequence=AAA35769.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q9BQ33 Q9P0Y2

Explore the universe of human proteins at neXtProt for APEH: NX_P13798

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13798

    • 4/18 DME Specific Peptides for APEH (P13798) (see all 18)
     LKVGFLP  VPRQLGE  GGKCELLSD  GSWKLLTID 

    APEH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001631.3  
    ENSEMBL proteins: 
     ENSP00000296456   ENSP00000414369   ENSP00000410149   ENSP00000402365   ENSP00000415862  
     ENSP00000401871   ENSP00000410366   ENSP00000404353   ENSP00000438180  

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    Uscn Proteins for APEH

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0031965nuclear membrane IDA--


    APEH for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for APEH

    Protein Domains /
    Families
    for APEH gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    APEH for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001375 Peptidase_S9
     IPR004106 Peptidase_S9A_B_C_N
     IPR002471 Pept_S9_AS
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry P13798

    ProtoNet protein and cluster: P13798

    1 Blocks protein family: IPB002471 Prolyl endopeptidase

    UniProtKB/Swiss-Prot: ACPH_HUMAN, P13798
    Similarity: Belongs to the peptidase S9C family


    Function
    for APEH gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACPH_HUMAN, P13798
    Function: This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an
    N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser
    Catalytic activity: Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide

         Genatlas biochemistry entry for APEH:
    N-acylaminoacyl-peptide hydrolase,with reduced expression in renal cell carcinoma (see D3F15S2,D3S94,TSG3C),highly
    homolog to the tightly linked MST1 gene

    Enzyme Number (IUBMB): EC 3.4.19.11 2

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--


    APEH for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for APEH:
     Decreased homologous recombina  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for APEH gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APEH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for APEH (P137982, 3 ENSP000002964564) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IST1P539902, 3, ENSP000003304084MINT-68393 I2D: score=5 STRING: ENSP00000330408
    UBA5Q9GZZ92, 3, ENSP000003485654MINT-67134 I2D: score=5 STRING: ENSP00000348565
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    MCCP235083, ENSP000003862274I2D: score=1 STRING: ENSP00000386227
    SHBGP042783, ENSP000003698164I2D: score=2 STRING: ENSP00000369816
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    APEH for ontologies           About GeneDecksing



    Drugs & Compounds
    for APEH gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APEH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APEH
    10/19 Novoseek chemical compound relationships for APEH gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraoxon 91.9 28 15642457 (3), 11753944 (2), 15294802 (2), 20138483 (1) (see all 21)
    diisopropylfluorophosphate 78.3 17 10719179 (3), 10731698 (3), 11921441 (1), 20441875 (1) (see all 6)
    methylparathion 75.4 4 16489921 (1), 11544037 (1), 14991648 (1), 15294802 (1)
    sarin 73.9 5 14985944 (2), 15033522 (1), 15888665 (1), 10421455 (1)
    coumaphos 73.7 3 16292554 (2), 15741066 (1)
    soman 71.9 3 15033522 (1), 14985944 (1), 10421455 (1)
    p-nitrophenol 67.1 5 17139155 (1), 17616234 (1), 11544037 (1), 14991648 (1) (see all 5)
    parathion 64.8 3 17139155 (1), 11544037 (1), 11118318 (1)
    chlorpyrifos 42.3 2 15888665 (1), 15294802 (1)
    serine 31.3 7 17241160 (2), 10719179 (1), 20221871 (1), 10731698 (1)

    Search CenterWatch for drugs/clinical trials and news about APEH / ACPH 

    Transcripts
    for APEH gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APEH gene: 
    NM_001640.3  

    Unigene Cluster for APEH:

    N-acylaminoacyl-peptide hydrolase
    Hs.517969  [show with all ESTs]
    Unigene Representative Sequence: BC000362
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296456(uc010hkw.1 uc003cxf.3) ENST00000449966 ENST00000483715
    ENST00000446089 ENST00000491799 ENST00000442186 ENST00000438011 ENST00000463995
    ENST00000462439 ENST00000447436 ENST00000463616 ENST00000457042 ENST00000447541
    ENST00000482301 ENST00000469362 ENST00000480772

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APEH (see all 7)
    OriGene shRNA RFP: APEH
    OriGene siRNA: APEH
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APEH

    Additional cDNA sequence: 

    AF141383.1 AK314962.1 BC000362.2 BC001499.2 BC001826.2 D38441.1 

    24/41 DOTS entries (see all 41):

    DT.85104237  DT.120904094  DT.95251572  DT.102840613  DT.120904071  DT.100828706  DT.120904126  DT.120904130 
    DT.120904428  DT.100045156  DT.100828712  DT.120904104  DT.92457317  DT.100828704  DT.102840617  DT.120904718 
    DT.100828708  DT.102840609  DT.95251481  DT.100828705  DT.120904208  DT.95251445  DT.120904784  DT.120904334 

    24/633 AceView cDNA sequences (see all 633):

    CR605044 AI951967 AA479866 BU166449 BU164381 CR618744 BM748199 BM726711 
    BG337635 F33318 BE782975 AI755262 AI912384 BM927172 BU181949 BM474285 
    BM014171 AW848458 BE646308 BM745745 BQ063344 AW467944 BM765691 AW578333 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for APEH (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
    SP1:                                                                                                                          -                             -   
    SP2:                                                                                                                    -     -     -                       -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                      -                                                                                                                     

    ExUns: 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for APEH

    Expression
    for APEH gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APEH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCTGATCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    APEH expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See APEH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APEH

    SOURCE GeneReport for Unigene cluster: Hs.517969
        SABiosciences Custom PCR Arrays for APEH
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    In Situ
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    Orthologs
    for APEH gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for APEH gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Apeh1 , 5 acylpeptide hydrolase1, 5 89.16(n)1
    91.39(a)1    		   9 (59.07 cM)5
    2356061  NM_146226.21  NP_666338.21 
     1080854175 
    chicken
    (Gallus gallus)    		 Aves APEH1 N-acylaminoacyl-peptide hydrolase 69.84(n)
    65.38(a)    		   415926  NM_001030585.1  NP_001025756.1 
    lizard
    (Anolis carolinensis)    		 Reptilia APEH6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 2(149574190-149591680)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.70362 Transcribed sequence with weak similarity to protein more 71.15(n)    BG886239.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii apeh2 acylpeptide hydrolase 73.17(n)   321028  BC048895.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 34(a)
    		 1 ↔ 1
    		 GroupUn.711(9155-13780)
    worm
    (Caenorhabditis elegans)    		 Secernentea R11E3.83
    dpf-51    		 Protein DPF-51 33(a)3
    46.01(n)1
    36.02(a)1    		   IV(4803026-4806763)3
    1772511  NM_068246.51  NP_500647.21 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G145701 acylaminoacyl-peptidase 45.43(n)
    36.29(a)    		   827104  NM_117537.3  NP_193193.2 
    rice
    (Oryza sativa)    		 Liliopsida Os10g04158001 hypothetical protein 44.63(n)
    36.97(a)    		   4348628  NM_001071138.1  NP_001064603.1 


    ENSEMBL Gene Tree for APEH (if available)
    TreeFam Gene Tree for APEH (if available) 

    Paralogs
    for APEH gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for APEH gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/216 NCBI SNPs in APEH are shown (see all 216)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1428277981,2
    		--49709582(+) TCTTCA/TTTTTA 1 -- us2k10--------
    rs763830091,2
    		C--49709928(+) TTTTTC/TTTGAG 1 -- us2k10--------
    rs67678781,2
    		C,F,A,H,--49710345(+) GTAACT/AGGGAC 1 -- us2k14Minor allele frequency- A:0.38NA 8
    rs130935251,2
    		C,--49710444(+) CCTGAG/CCTCGT 1 -- us2k14Minor allele frequency- C:0.00NA 8
    rs130933851,2
    		C,F,--49710479(+) agtgcA/Tgggat 1 -- us2k15Minor allele frequency- T:0.42NA 12
    rs669064651,2
    		C--49710515(-) AAAGT-/CCCG  
                GCCGG     		1 -- us2k11Minor allele frequency- CCCG:0.00NA 2
    rs1895446261,2
    		--49710587(+) GGCTGA/TTGGGA 1 -- us2k10--------
    rs1807411411,2
    		--49710598(+) AAGGGA/GAAGCT 1 -- us2k10--------
    rs1509021781,2
    		--49710668(+) CTGAAC/TGTGGA 1 -- us2k10--------
    rs1148388571,2
    		--49710895(+) AGGGAC/TCCACC 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for APEH (49711435 - 49721396 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for APEH
         1 CNV: 68370

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for APEH gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APEH for disorders           About GeneDecksing

    OMIM gene information: 102645    OMIM disorders: --

    20/27 diseases for APEH (see all 27):    About MalaCards
    renal cell carcinoma    lung carcinoma    carcinoma    high pressure neurological syndrome
    placenta praevia    barbiturate dependence    sclerosing cholangitis    primary sclerosing cholangitis
    placental abruption    primary biliary cirrhosis    cholangitis    cholestasis
    crohn's disease    tonsillitis    lung cancer    acute pancreatitis
    liver disease    hypertension    pharyngitis    blindness

    5 diseases from the University of Copenhagen DISEASES database for APEH:
    Placenta praevia     High pressure neurological syndrome     Barbiturate dependence     Hypertrophic cardiomyopathy
    Placental abruption

    8 Novoseek disease relationships for APEH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poisoning 22.7 3 12857941 (1), 14985944 (1), 15888665 (1)
    small cell lung cancer 21 2 8724851 (1), 1655021 (1)
    cholestasis 13.9 2 10925723 (1), 8210624 (1)
    immunodeficiency 7.57 4 1525395 (1), 8347129 (1), 2241099 (1), 1525334 (1)
    tumors 2.05 1 1655021 (1)
    intoxication 0 1 12857941 (1)
    carcinoma 0 1 1328432 (1)
    carcinoma renal cell 0 4 1861871 (2), 1655021 (1)

    Human Genome Epidemiology (HuGE) Navigator: APEH (2 documents)

    Export disorders for APEH gene to outside databases

    Publications
    for APEH gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APEH gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with APEH)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase. (PubMed id 10719179)1, 2, 9 Fujino T.... Yasuda H. (2000)
    2. Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities. (PubMed id 2006156)1, 2, 9 Jones W.M....Manning J.M. (1991)
    3. The nucleotide sequence of human acylamino acid-releasing enzyme. (PubMed id 8724851)1, 2, 9 Mitta M.... Tsunasawa S. (1996)
    4. The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase. (PubMed id 1861871)1, 2, 9 Erlandsson R.... Joernvall H. (1991)
    5. Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme. (PubMed id 1740429)1, 2, 9 Scaloni A.... Manning J.M. (1992)
    6. Crystallization and preliminary X-ray studies of human erythrocyte acylpeptide hydrolase. (PubMed id 8411161)1, 2, 9 Feese M.... Remington S.J. (1993)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Structural investigations on human erythrocyte acylpeptide hydrolase by mass spectrometric procedures. (PubMed id 10395453)1, 2 Scaloni A....Manning J.M. (1999)
    9. A gene near the D3F15S2 site on 3p is expressed in normal human kidney but not or only at a severely reduced level in 11 of 15 primary renal cell carcinomas (RCC). (PubMed id 2392324)1, 3 Erlandsson R....Lee E. (1990)
    10. The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer. (PubMed id 2565880)1, 2 Naylor S.L....Sakaguchi A.Y. (1989)

    External Searches for APEH gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing APEH gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 327 HGNC: 586 AceView: APEH Ensembl:ENSG00000164062 euGenes: HUgn327
    ECgene: APEH H-InvDB: APEH

    Other Databases showing APEH gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing APEH gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APEH Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APEH Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for APEH gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for APEH gene:
    Search GeneIP for patents involving APEH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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