Aliases for APCS Gene
Aliases for APCS Gene
External Ids for APCS Gene
- HGNC: 584
- Entrez Gene: 325
- Ensembl: ENSG00000132703
- OMIM: 104770
- UniProtKB: P02743
Previous GeneCards Identifiers for APCS Gene
- GC01P157349
- GC01P155289
- GC01P156335
- GC01P156774
- GC01P156370
- GC01P157824
- GC01P130914
Summaries for APCS Gene
-
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
GeneCards Summary for APCS Gene
APCS (Amyloid P Component, Serum) is a Protein Coding gene. Diseases associated with APCS include Candidiasis and Carotenemia. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include calcium ion binding and unfolded protein binding. An important paralog of this gene is CRP.
UniProtKB/Swiss-Prot for APCS Gene
-
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APCS Gene
Genomics for APCS Gene
GeneHancer (GH) Regulatory Elements for APCS Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01I159587 | Promoter | 0.9 | EPDnew | 550.8 | 0.0 | -18 | 0.1 | FOXA2 RXRA TAF1 MAX REST RAD21 FOXA1 NR2F2 YY1 JUND | APCS GC01M159580 GC01P159502 | |
GH01I159596 | Enhancer | 0.9 | Ensembl ENCODE | 0.4 | +10.1 | 10149 | 2.7 | FOXA2 JUN MAX RAD21 YY1 GATA3 FOSL2 RXRA CEBPB EP300 | OR10J6P OR10J5 OR10J3 DUSP23 SLAMF9 APCS GC01P159502 |
Regulatory Element Products
Genomic Locations for APCS Gene
- chr1:159,587,825-159,588,871
- (GRCh38/hg38)
- Size:
- 1,047 bases
- Orientation:
- Plus strand
- chr1:159,557,615-159,558,661
- (GRCh37/hg19)
Genomic View for APCS Gene
- Cytogenetic band:
-
- 1q23.2 by Ensembl
- 1q23.2 by Entrez Gene
- 1q23.2 by HGNC


RefSeq DNA sequence for APCS Gene
Proteins for APCS Gene
-
Protein details for APCS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02743-SAMP_HUMAN
- Recommended name:
- Serum amyloid P-component
- Protein Accession:
- P02743
Protein attributes for APCS Gene
- Size:
- 223 amino acids
- Molecular mass:
- 25387 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits.
Protein Expression for APCS Gene
Post-translational modifications for APCS Gene
- N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).
- Glycosylation at posLast=5151
Other Protein References for APCS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
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-
Abcam assays for APCS
No data available for DME Specific Peptides for APCS Gene
Domains & Families for APCS Gene
Gene Families for APCS Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Potential drug targets
- Predicted secreted proteins
- Transporters
Protein Domains for APCS Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for APCS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P02743- Family:
-
- Belongs to the pentraxin family.
Function for APCS Gene
Molecular function for APCS Gene
- GENATLAS Biochemistry:
- amyloid P component,serum,pentaxin (pentraxin) family
- UniProtKB/Swiss-Prot Function:
- Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
Phenotypes From GWAS Catalog for APCS Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001849 | complement component C1q binding | IDA | 23544079 |
GO:0005509 | calcium ion binding | IDA | 23544079 |
GO:0030246 | carbohydrate binding | IEA | -- |
GO:0042802 | identical protein binding | IPI | 19372378 |
GO:0046790 | virion binding | IDA | 23544079 |
Phenotypes for APCS Gene
- MGI mutant phenotypes for APCS:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for APCS:
Animal Model Products
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- Yeast expression
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for APCS Gene
Localization for APCS Gene
Subcellular locations from UniProtKB/Swiss-Prot for APCS Gene
- Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS,IDA | -- |
GO:0005615 | extracellular space | TAS,IDA | 14607961 |
GO:0005634 | nucleus | HDA,IDA | 21630459 |
GO:0031012 | colocalizes_with extracellular matrix | IDA | 20551380 |
GO:0070062 | extracellular exosome | HDA,IDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for APCS Gene
Pathways & Interactions for APCS Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
2 | Metabolism of proteins |
Pathways by source for APCS Gene
2 Reactome pathways for APCS Gene
Interacting Proteins for APCS Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002674 | negative regulation of acute inflammatory response | IC | 14607961 |
GO:0006457 | protein folding | TAS | 10812074 |
GO:0006953 | acute-phase response | TAS | 2987268 |
GO:0044267 | cellular protein metabolic process | TAS | -- |
GO:0044869 | negative regulation by host of viral exo-alpha-sialidase activity | IDA | 23544079 |
No data available for SIGNOR curated interactions for APCS Gene
Drugs & Compounds for APCS Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Copper | Approved, Investigational | Pharma | Target | 202 | ||
Zinc | Approved, Investigational | Pharma | Target | 2430 | ||
calcium | Approved | Nutra | 0 | |||
BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE | Experimental | Pharma | Target | 0 | ||
BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for APCS Gene
mRNA/cDNA for APCS Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (177) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for APCS Gene
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-
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
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- Yeast expression
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Expression for APCS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for APCS Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APCS Gene
NURSA nuclear receptor signaling pathways regulating expression of APCS Gene:
APCSSOURCE GeneReport for Unigene cluster for APCS Gene:
Hs.507080mRNA Expression by UniProt/SwissProt for APCS Gene:
P02743-SAMP_HUMANEvidence on tissue expression from TISSUES for APCS Gene
- Liver(4.9)
- Bone marrow(4.3)
- Muscle(4.2)
- Blood(2.6)
- Spleen(2.1)
- Heart(2)
- Kidney(2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for APCS
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No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for APCS Gene
Orthologs for APCS Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | APCS 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | APCS 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Apcs 33 |
|
||
mouse (Mus musculus) |
Mammalia | Apcs 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | APCS 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | CRP 34 |
|
OneToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
zebrafish (Danio rerio) |
Actinopterygii | crp2 34 |
|
ManyToMany | |
crp3 34 |
|
ManyToMany | |||
crp7 34 |
|
ManyToMany | |||
crp 34 |
|
ManyToMany | |||
crp1 34 |
|
ManyToMany | |||
crp6 34 |
|
ManyToMany | |||
si:ch211-234p6.9 34 |
|
ManyToMany |
- Species where no ortholog for APCS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for APCS Gene
Variants for APCS Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_035814 | A breast cancer sample | p.Gly141Ser | |||
rs1000102078 | -- | 159,588,417(+) | G/T | coding_sequence_variant, missense_variant | |
rs1002441835 | -- | 159,586,909(+) | G/C | upstream_transcript_variant | |
rs1002494109 | -- | 159,587,322(+) | T/C | upstream_transcript_variant | |
rs1003344971 | -- | 159,588,226(+) | C/T | coding_sequence_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3578214 | CNV | loss | 25503493 |
nsv1005195 | CNV | gain | 25217958 |
Additional Variant Information for APCS Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- APCS
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APCS Gene
Disorders for APCS Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
candidiasis |
|
|
carotenemia |
|
|
candida glabrata |
|
|
human immunodeficiency virus type 1 |
|
|
splenic artery aneurysm |
|
|
UniProtKB/Swiss-Prot
SAMP_HUMAN- Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
Additional Disease Information for APCS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for APCS Gene
Publications for APCS Gene
- Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. (PMID: 15649951) Soares ML … Buxbaum JN (Human molecular genetics 2005) 3 22 44 58
- Human serum amyloid P component. cDNA isolation, complete sequence of pre-serum amyloid P component, and localization of the gene to chromosome 1. (PMID: 2987268) Mantzouranis EC … Colten HR (The Journal of biological chemistry 1985) 2 3 4 58
- Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 44 58
- Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 44 58
- Serum amyloid P and cardiovascular disease in older men and women: results from the Cardiovascular Health Study. (PMID: 17138933) Jenny NS … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2007) 3 22 58
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- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for APCS
- antibodies-online: Search results for 134 available APCS Antibodies ranked by validation data
- Compare Top APCS Antibodies
- Quality Products:
- ABIN2777091
- ABIN654634
- ABIN954752
- ABIN1573937
- ABIN3042514
- ABIN3042513
- ABIN954751
- ABIN203493
- ABIN658915
- ABIN1500899
- ABIN2777091
- ABIN654634
- ABIN954752
- ABIN1573937
- ABIN3042514
- ABIN3042513
- ABIN954751
- ABIN203493
- ABIN658915
- ABIN1500899
- ABIN2777091
- ABIN654634
- ABIN954752
- ABIN1573937
- ABIN3042514
- ABIN3042513
- ABIN954751
- ABIN203493
- ABIN658915
- ABIN1500899
- antibodies-online: Search results for 48 available APCS Elisa Kits ranked by validation data
- Compare Top APCS Elisa Kits
- Quality Products:
- ABIN1889378
- ABIN1572274
- ABIN612669
- ABIN1566650
- ABIN5564615
- ABIN628529
- ABIN628879
- ABIN1058358
- ABIN1566649
- ABIN1058357
- ABIN1889378
- ABIN1572274
- ABIN612669
- ABIN1566650
- ABIN5564615
- ABIN628529
- ABIN628879
- ABIN1058358
- ABIN1566649
- ABIN1058357
- ABIN1889378
- ABIN1572274
- ABIN612669
- ABIN1566650
- ABIN5564615
- ABIN628529
- ABIN628879
- ABIN1058358
- ABIN1566649
- ABIN1058357
- antibodies-online: Search results for 34 available APCS Proteins ranked by validation data
- Compare Top APCS Proteins
- Quality Products:
- ABIN3076502
- ABIN3132903
- ABIN2180596
- ABIN2666527
- ABIN1611368
- ABIN2007344
- ABIN2122074
- ABIN934795
- ABIN4371512
- ABIN2005808
- ABIN3076502
- ABIN3132903
- ABIN2180596
- ABIN2666527
- ABIN1611368
- ABIN2007344
- ABIN2122074
- ABIN934795
- ABIN4371512
- ABIN2005808
- ABIN3076502
- ABIN3132903
- ABIN2180596
- ABIN2666527
- ABIN1611368
- ABIN2007344
- ABIN2122074
- ABIN934795
- ABIN4371512
- ABIN2005808
- GeneTex APCS antibody for APCS
- Search GeneTex for Proteins for APCS
- ViGene Biosciences adenoviral particle packaged cDNA for APCS gene
- ViGene Biosciences lentiviral particle packaged cDNA for APCS gene
- ViGene Biosciences ready-to-package AAV shRNAs for APCS gene
- Search ViGene Biosciences for APCS
- Santa Cruz Biotechnology (SCBT) Antibodies for APCS
- Search Santa Cruz Biotechnology (SCBT) for APCS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for APCS
- Horizon Cell Lines for APCS
- genomics-online: cdna clones - Search results for available APCS gene related products
- orf clones - Search results for available APCS gene related products
- genomics-online: gRNA clones - Search results for available APCS gene related products
- genomics-online: primer clones - Search results for available APCS gene related products
- genomics-online: shRNA clones - Search results for available APCS gene related products
Sources for APCS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew