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Aliases for APCDD1L Gene

Aliases for APCDD1L Gene

  • APC Down-Regulated 1 Like 2 3 5
  • Adenomatosis Polyposis Coli Down-Regulated 1 Protein-Like 4
  • Adenomatosis Polyposis Coli Down-Regulated 1-Like 2

External Ids for APCDD1L Gene

Previous GeneCards Identifiers for APCDD1L Gene

  • GC20M056468
  • GC20M057034
  • GC20M053817

Summaries for APCDD1L Gene

GeneCards Summary for APCDD1L Gene

APCDD1L (APC Down-Regulated 1 Like) is a Protein Coding gene. An important paralog of this gene is APCDD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APCDD1L Gene

Genomics for APCDD1L Gene

Regulatory Elements for APCDD1L Gene

Enhancers for APCDD1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F058541 0.9 Ensembl ENCODE 37.3 -26.6 -26637 1.2 SMARCE1 KLF1 PKNOX1 JUN CEBPB USF2 ZBTB7A RAD51 JUND ATF3 APCDD1L APCDD1L-AS1 GC20M058516 ENSG00000254620
GH20F058547 0.7 ENCODE 28.3 -32.7 -32655 1.3 RCOR1 ZMIZ1 ETV6 PRDM10 MAFK CHD2 MAZ ZBTB8A EP300 JUND APCDD1L APCDD1L-AS1 GC20M058516 ENSG00000254620
GH20F058549 0.7 FANTOM5 ENCODE 17 -35.1 -35125 1.3 INSM2 FEZF1 RAD21 RFX5 GLIS2 HSF1 SCRT2 RCOR1 FOS ZNF843 APCDD1L APCDD1L-AS1 GC20M058516 ENSG00000254620
GH20F058479 0.9 Ensembl ENCODE 11.5 +34.6 34633 2.7 GTF2F1 CTCF ESRRA SIN3A DMAP1 RAD21 GATA3 POLR2A SMC3 FOS APCDD1L APCDD1L-AS1 GNAS GNAS-AS1 ANKRD60 VAPB
GH20F058568 0.7 ENCODE 11.3 -55.2 -55209 5.0 PKNOX1 MAX ZNF384 CEBPG ZIC2 RAD21 ZFHX2 FOXK2 SCRT2 ETV6 APCDD1L APCDD1L-AS1 ENSG00000254620 GC20M058516
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around APCDD1L on UCSC Golden Path with GeneCards custom track

Promoters for APCDD1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001450106 493 1401 ELF3 SIN3A RAD21 ZNF335 GLIS2 ELK1 HSF1 SCRT2 ZNF143 ZNF207

Genomic Location for APCDD1L Gene

Chromosome:
20
Start:
58,452,469 bp from pter
End:
58,515,393 bp from pter
Size:
62,925 bases
Orientation:
Minus strand

Genomic View for APCDD1L Gene

Genes around APCDD1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APCDD1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APCDD1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APCDD1L Gene

Proteins for APCDD1L Gene

  • Protein details for APCDD1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCL9-APCDL_HUMAN
    Recommended name:
    Protein APCDD1-like
    Protein Accession:
    Q8NCL9

    Protein attributes for APCDD1L Gene

    Size:
    501 amino acids
    Molecular mass:
    55635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APCDD1L Gene

Post-translational modifications for APCDD1L Gene

  • Glycosylation at Asn 150
  • Modification sites at PhosphoSitePlus

Other Protein References for APCDD1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APCDD1L Gene

Domains & Families for APCDD1L Gene

Protein Domains for APCDD1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APCDD1L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APCDD1L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for APCDD1L Gene

Function for APCDD1L Gene

genes like me logo Genes that share phenotypes with APCDD1L: view

Animal Model Products

miRNA for APCDD1L Gene

miRTarBase miRNAs that target APCDD1L

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APCDD1L Gene

Localization for APCDD1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for APCDD1L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APCDD1L Gene COMPARTMENTS Subcellular localization image for APCDD1L gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for APCDD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APCDD1L: view

Pathways & Interactions for APCDD1L Gene

SuperPathways for APCDD1L Gene

No Data Available

Interacting Proteins for APCDD1L Gene

Gene Ontology (GO) - Biological Process for APCDD1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for APCDD1L Gene

Transcripts for APCDD1L Gene

mRNA/cDNA for APCDD1L Gene

Unigene Clusters for APCDD1L Gene

Adenomatosis polyposis coli down-regulated 1-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APCDD1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2:
SP3:

Relevant External Links for APCDD1L Gene

GeneLoc Exon Structure for
APCDD1L
ECgene alternative splicing isoforms for
APCDD1L

Expression for APCDD1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for APCDD1L Gene

mRNA differential expression in normal tissues according to GTEx for APCDD1L Gene

This gene is overexpressed in Minor Salivary Gland (x8.7), Artery - Aorta (x8.3), and Bladder (x5.3).

Protein differential expression in normal tissues from HIPED for APCDD1L Gene

This gene is overexpressed in Frontal cortex (42.9) and Fetal testis (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APCDD1L Gene



Protein tissue co-expression partners for APCDD1L Gene

NURSA nuclear receptor signaling pathways regulating expression of APCDD1L Gene:

APCDD1L

SOURCE GeneReport for Unigene cluster for APCDD1L Gene:

Hs.119286
genes like me logo Genes that share expression patterns with APCDD1L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for APCDD1L Gene

Orthologs for APCDD1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for APCDD1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APCDD1L 34 35
  • 99 (n)
dog
(Canis familiaris)
Mammalia APCDD1L 34 35
  • 84.87 (n)
cow
(Bos Taurus)
Mammalia APCDD1L 34 35
  • 81.93 (n)
rat
(Rattus norvegicus)
Mammalia Apcdd1l 34
  • 75.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia APCDD1L 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APCDD1L 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves APCDD1L 34
  • 68.57 (n)
PGO2 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APCDD1L 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100001408 34
  • 57.46 (n)
apcdd1l 35
  • 46 (a)
OneToOne
Species where no ortholog for APCDD1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APCDD1L Gene

ENSEMBL:
Gene Tree for APCDD1L (if available)
TreeFam:
Gene Tree for APCDD1L (if available)

Paralogs for APCDD1L Gene

Paralogs for APCDD1L Gene

(1) SIMAP similar genes for APCDD1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with APCDD1L: view

Variants for APCDD1L Gene

Sequence variations from dbSNP and Humsavar for APCDD1L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10211740 -- 58,490,397(+) ttcac(A/G)ccatg intron-variant
rs10580833 -- 58,479,594(+) TTTGC(-/T)TTTTT intron-variant
rs10601961 -- 58,494,303(+) TCTCT(-/TC)TCTCT intron-variant
rs10683548 -- 58,509,018(+) GTGTG(-/TG/TGTG)GAGTC intron-variant
rs1077349 -- 58,497,042(-) CTGGC(C/T)GGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APCDD1L Gene

Variant ID Type Subtype PubMed ID
esv3389917 CNV duplication 20981092
nsv1063462 CNV gain 25217958
nsv1148136 CNV duplication 26484159
nsv3428 CNV deletion 18451855
nsv525781 CNV loss 19592680
nsv834019 CNV loss 17160897

Variation tolerance for APCDD1L Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APCDD1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APCDD1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APCDD1L Gene

Disorders for APCDD1L Gene

Relevant External Links for APCDD1L

Genetic Association Database (GAD)
APCDD1L
Human Genome Epidemiology (HuGE) Navigator
APCDD1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APCDD1L

No disorders were found for APCDD1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APCDD1L Gene

Publications for APCDD1L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. (PMID: 20838585) Smith E.N. … Murray S.S. (PLoS Genet. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for APCDD1L Gene

Sources for APCDD1L Gene

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