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Aliases for APCDD1L Gene

Aliases for APCDD1L Gene

  • Adenomatosis Polyposis Coli Down-Regulated 1-Like 2 3
  • Adenomatosis Polyposis Coli Down-Regulated 1 Protein-Like 4

External Ids for APCDD1L Gene

Previous GeneCards Identifiers for APCDD1L Gene

  • GC20M056468
  • GC20M057034
  • GC20M053817

Summaries for APCDD1L Gene

GeneCards Summary for APCDD1L Gene

APCDD1L (Adenomatosis Polyposis Coli Down-Regulated 1-Like) is a Protein Coding gene. An important paralog of this gene is APCDD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APCDD1L Gene

Genomics for APCDD1L Gene

Regulatory Elements for APCDD1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APCDD1L Gene

58,452,469 bp from pter
58,515,393 bp from pter
62,925 bases
Minus strand

Genomic View for APCDD1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APCDD1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APCDD1L Gene

Proteins for APCDD1L Gene

  • Protein details for APCDD1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein APCDD1-like
    Protein Accession:

    Protein attributes for APCDD1L Gene

    501 amino acids
    Molecular mass:
    55635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APCDD1L Gene

Proteomics data for APCDD1L Gene at MOPED

Post-translational modifications for APCDD1L Gene

  • Glycosylation at Asn 150
  • Modification sites at PhosphoSitePlus

Other Protein References for APCDD1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APCDD1L Gene

Domains & Families for APCDD1L Gene

Protein Domains for APCDD1L Gene


Suggested Antigen Peptide Sequences for APCDD1L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APCDD1L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for APCDD1L Gene

Function for APCDD1L Gene

Phenotypes for APCDD1L Gene

GenomeRNAi human phenotypes for APCDD1L:
genes like me logo Genes that share phenotypes with APCDD1L: view

Animal Model Products

CRISPR Products

miRNA for APCDD1L Gene

miRTarBase miRNAs that target APCDD1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for APCDD1L Gene

Localization for APCDD1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for APCDD1L Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for APCDD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APCDD1L: view

No data available for Subcellular locations from COMPARTMENTS for APCDD1L Gene

Pathways & Interactions for APCDD1L Gene

SuperPathways for APCDD1L Gene

No Data Available

Interacting Proteins for APCDD1L Gene

Gene Ontology (GO) - Biological Process for APCDD1L Gene


No data available for Pathways by source and SIGNOR curated interactions for APCDD1L Gene

Drugs & Compounds for APCDD1L Gene

No Compound Related Data Available

Transcripts for APCDD1L Gene

Unigene Clusters for APCDD1L Gene

Adenomatosis polyposis coli down-regulated 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APCDD1L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APCDD1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -

Relevant External Links for APCDD1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APCDD1L Gene

mRNA expression in normal human tissues for APCDD1L Gene

mRNA differential expression in normal tissues according to GTEx for APCDD1L Gene

This gene is overexpressed in Minor Salivary Gland (x8.7), Artery - Aorta (x8.3), and Bladder (x5.3).

Protein differential expression in normal tissues from HIPED for APCDD1L Gene

This gene is overexpressed in Frontal cortex (42.9) and Fetal testis (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APCDD1L Gene

SOURCE GeneReport for Unigene cluster for APCDD1L Gene Hs.119286

genes like me logo Genes that share expression patterns with APCDD1L: view

Protein tissue co-expression partners for APCDD1L Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for APCDD1L Gene

Orthologs for APCDD1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for APCDD1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia APCDD1L 35
  • 81.93 (n)
  • 80.92 (a)
  • 79 (a)
(Canis familiaris)
Mammalia APCDD1L 35
  • 84.87 (n)
  • 83.33 (a)
  • 83 (a)
(Pan troglodytes)
Mammalia APCDD1L 35
  • 99 (n)
  • 99.2 (a)
  • 94 (a)
(Rattus norvegicus)
Mammalia Apcdd1l 35
  • 75.39 (n)
  • 69.62 (a)
(Monodelphis domestica)
Mammalia APCDD1L 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia APCDD1L 36
  • 65 (a)
(Gallus gallus)
Aves APCDD1L 35
  • 68.57 (n)
  • 63.64 (a)
PGO2 36
  • 60 (a)
(Anolis carolinensis)
Reptilia APCDD1L 36
  • 60 (a)
(Danio rerio)
Actinopterygii LOC100001408 35
  • 57.46 (n)
  • 55.02 (a)
apcdd1l 36
  • 46 (a)
Species with no ortholog for APCDD1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APCDD1L Gene

Gene Tree for APCDD1L (if available)
Gene Tree for APCDD1L (if available)

Paralogs for APCDD1L Gene

Paralogs for APCDD1L Gene

(1) SIMAP similar genes for APCDD1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with APCDD1L: view

Variants for APCDD1L Gene

Sequence variations from dbSNP and Humsavar for APCDD1L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs723506 -- 58,469,718(-) GGGAC(A/G)TGAGT intron-variant
rs723507 -- 58,469,654(-) CCCAC(A/G)CCCAC intron-variant
rs725400 -- 58,503,174(-) AAATC(A/T)CTGAG intron-variant
rs749209 -- 58,513,133(-) ATGGA(A/G)CAGTC intron-variant
rs749210 -- 58,512,656(-) GGGCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APCDD1L Gene

Variant ID Type Subtype PubMed ID
nsv834019 CNV Loss 17160897
nsv3428 CNV Loss 18451855
nsv525781 CNV Loss 19592680

Variation tolerance for APCDD1L Gene

Residual Variation Intolerance Score: 78.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APCDD1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APCDD1L Gene

Disorders for APCDD1L Gene

Relevant External Links for APCDD1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with APCDD1L: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APCDD1L Gene

Publications for APCDD1L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  2. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study. (PMID: 20838585) Smith E.N. … Murray S.S. (PLoS Genet. 2010) 67
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for APCDD1L Gene

Sources for APCDD1L Gene

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