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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APCDD1L Gene

protein-coding GIFtS: 40
GCID: GC20M057034

adenomatosis polyposis coli down-regulated 1-like

Explore 1 disease affiliated with
APCDD1L via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenomatosis Polyposis Coli Down-Regulated 1-Like¹ ²
Adenomatosis Polyposis Coli Down-Regulated 1 Protein-Like² ³
FLJ90166¹
Protein APCDD1-Like²

External Ids:	HGNC: 26892¹	Entrez Gene: 164284²	Ensembl: ENSG00000198768⁷	UniProtKB: Q8NCL9³

Export aliases for APCDD1L gene to outside databases

Previous GC identifers: GC20M056468 GC20M053817

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APCDD1L gene promoter:
Sox5 FOXF2 AML1a CUTL1 POU6F1 (c2) E47 N-Myc HEN1 GATA-6 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APCDD1L promoter sequence

Search SABiosciences Chromatin IP Primers for APCDD1L

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APCDD1L

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.32 Ensembl cytogenetic band: 20q13.32 HGNC cytogenetic band: 20q13.32

APCDD1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APCDD1L gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M057034: view genomic region (about GC identifiers)

Start:	57,034,157 bp from pter	End:	57,090,187 bp from pter
Size:	56,031 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: APCDL_HUMAN, Q8NCL9 (See protein sequence)

Recommended Name: Protein APCDD1-like precursor

Size: 501 amino acids; 55635 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for APCDD1L: NX_Q8NCL9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NCL9

APCDD1L Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_699191.1

ENSEMBL proteins:

ENSP00000360191 ENSP00000396856 ENSP00000413261

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

APCDD1L for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8NCL9

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for APCDD1L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for APCDD1L gene:

NM_153360.1

Unigene Cluster for APCDD1L:

Adenomatosis polyposis coli down-regulated 1-like

Hs.119286 [show with all ESTs]

Unigene Representative Sequence: AK074647

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371149(uc002xze.1 uc010zzp.1) ENST00000491015 ENST00000425773

ENST00000439429

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Additional cDNA sequence:

AK074647.1 AK293299.1 BC101758.1 BC101760.1

5 DOTS entries:

DT.106688 DT.120810068 DT.120810052 DT.120810027 DT.99998854

24/29 AceView cDNA sequences (see all 29):

AK074647 BM720248 BG424456 BI966088 BQ018966 NM_153360 BP355425 AA436457

AA027103 AW028319 BM672000 AA126730 AI130743 BU632159 BG424380 BG326592

BP355406 BU625813 CA425076 AA436504 CA426636 BU624018 AA376386 AW291228

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for APCDD1L About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6
SP1:					-
SP2:
SP3:

ECgene alternative splicing isoforms for APCDD1L

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APCDD1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCCAGGGC

About this image

APCDD1L expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See APCDD1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APCDD1L

SOURCE GeneReport for Unigene cluster: Hs.119286

SABiosciences Custom PCR Arrays for APCDD1L

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for APCDD1L gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	APCDD1L¹	adenomatosis polyposis coli down-regulated 1-like	68.66(n) 64.1(a)		419316 XM_417488.3 XP_417488.2
lizard (Anolis carolinensis)	Reptilia	APCDD1L⁶	--	60(a)	1 ↔ 1	GL343217.1(30830-39459)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BQ526655.1²	--	73.19(n)		BQ526655.1
zebrafish (Danio rerio)	Actinopterygii	LOC100001408¹	protein APCDD1-like	57.59(n) 55.15(a)		100001408 XM_001341376.2 XP_001341412.1
honey bee (Apis mellifera)	Insecta	--	--	17(a)	1 → many	Group14.2(602488-605292)

Species with no ortholog for APCDD1L

ENSEMBL Gene Tree for APCDD1L (if available)
TreeFam Gene Tree for APCDD1L (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for APCDD1L gene

APCDD1²

1 SIMAP similar gene for APCDD1L using alignment to 3 protein entries: APCDL_HUMAN (see all proteins):

APCDD1

APCDD1L for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142546037^1,2	C,F	other	57036180(+)	`CATCCC/TGCTCA`	2	Q R	mis¹		1		NA	4510
rs148101735^1,2		--	57034095(+)	`AAGACA/GCTCCA`	1	--	ds500¹		0	--	--	--	--
rs142864667^1,2		--	57034229(+)	`AGCTTC/TGGATA`	1	--	ds500¹		0	--	--	--	--
rs61503079^1,2	F,	--	57034231(+)	`CTTCGG/CATACA`	1	--	ds500¹		1		WA	118
rs192145697^1,2		--	57034244(+)	`ACCTGC/TTCAGC`	1	--	ds500¹		0	--	--	--	--
rs73183232^1,2	C,F,	--	57034301(+)	`CCCAAC/TCCTGA`	1	--	ds500¹		4		CSA WA NA	242
rs117945194^1,2		--	57034579(+)	`ATCAGG/AAGGAG`	1	--	ut3¹		1		EA	120
rs144981366^1,2		--	57034656(+)	`TTTCAC/TAGTGT`	1	--	ut3¹		0	--	--	--	--
rs6070471^1,2	C,H	--	57034762(+)	`TATTAG/AGATTA`	1	--	ut3¹		6		NS EA NA	420
rs138838402^1,2		--	57034808(+)	`TGTCGC/TCATGT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for APCDD1L (57034157 - 57090187 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APCDD1L: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

APCDD1L for disorders About GeneDecksing

1 disease for APCDD1L: About MalaCards

polyposis

Human Genome Epidemiology (HuGE) Navigator: APCDD1L (1 document)

Export disorders for APCDD1L gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for APCDD1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with APCDD1L)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Longitudinal genome-wide association of cardiovascula r disease risk factors in the bogalusa heart study. (PubMed id 20838585)¹ Smith E.N....Murray S.S. (2010)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (2005)
Drapc1 expression during mouse embryonic development. (PubMed id 15465500)¹ Jukkola T....Partanen J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 164284	HGNC: 26892	AceView: FLJ90166	Ensembl:ENSG00000198768	euGenes: HUgn164284
ECgene: APCDD1L	H-InvDB: APCDD1L

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for APCDD1L	Pharmacogenomics, SNPs, Pathways

Intellectual Property for APCDD1L gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for APCDD1L gene:
Search GeneIP for patents involving APCDD1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APCDD1L

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Hot genes Disease genes APCDD1L gene at Home site.

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APCDD1L Gene

adenomatosis polyposis coli down-regulated 1-like

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APCDD1L Gene

adenomatosis polyposis coli down-regulated 1-like

Aliasesfor APCDD1L gene

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for APCDD1L gene

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