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APCDD1 Gene

protein-coding   GIFtS: 52
GCID: GC18P010444

Adenomatosis Polyposis Coli Down-Regulated 1

  See APCDD1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenomatosis Polyposis Coli Down-Regulated 11 2     HTS2 5
Adenomatosis Polyposis Coli Down-Regulated 1 Protein2 3     B73232
DRAPC12 3     Hypoptrichosis Simplex2
HHS2 5     Protein APCDD12

External Ids:    HGNC: 157181   Entrez Gene: 1474952   Ensembl: ENSG000001548567   OMIM: 6074795   UniProtKB: Q8J0253   

Export aliases for APCDD1 gene to outside databases

Previous GC identifers: GC00U991017 GC18P010511


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APCDD1 Gene:
This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with
hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal
carcinogenesis.(provided by RefSeq, Sep 2010)

GeneCards Summary for APCDD1 Gene:
APCDD1 (adenomatosis polyposis coli down-regulated 1) is a protein-coding gene. Diseases associated with APCDD1 include hypotrichosis 1, and hypotrichosis simplex. GO annotations related to this gene include Wnt-protein binding. An important paralog of this gene is APCDD1L.

UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025
Function: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and
functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in
colorectal tumorigenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010859.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the APCDD1 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for APCDD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APCDD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.22   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.21

APCDD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APCDD1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P010444:  view genomic region     (about GC identifiers)

Start:
10,454,625 bp from pter      End:
10,489,945 bp from pter
Size:
35,321 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025 (See protein sequence)
Recommended Name: Protein APCDD1 precursor  
Size: 514 amino acids; 58797 Da
Subunit: Homodimer. Interacts with LRP5 and WNT3A
Sequence caution: Sequence=AAQ04816.1; Type=Frameshift; Positions=133; Sequence=BAG62412.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAG64192.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: B4DUQ0 B4DZT0 Q71M25

Explore the universe of human proteins at neXtProt for APCDD1: NX_Q8J025

Explore proteomics data for APCDD1 at MOPED

Post-translational modifications: 

  • N-Glycosylated1
  • Glycosylation2 at Asn100, Asn168, Asn319
  • Modification sites at PhosphoSitePlus

  • See APCDD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_694545.1  
    ENSEMBL proteins: 
     ENSP00000347433   ENSP00000404930   ENSP00000463110   ENSP00000463104   ENSP00000476491  
     ENSP00000464649  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8J025

    UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025
    Similarity: Belongs to the APCDD1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APCD1_HUMAN, Q8J025
    Function: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and
    functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in
    colorectal tumorigenesis
    Induction: Target gene of the Wnt/Beta-catenin pathway, transcriptionally regulated by the CTNNB1/TF7L2 complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017147Wnt-protein binding IDA--
         
    Find genes that share ontologies with APCDD1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Apcdd1):
     no phenotypic analysis 

    Find genes that share phenotypes with APCDD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Apcdd1tm1.1Hsav for APCDD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APCDD1
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    miRNA
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    miRTarBase miRNAs that target APCDD1:
    hsa-mir-193b-3p (MIRT016559)

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    Selected qRT-PCR Assays for microRNAs that regulate APCDD1 (see all 25):
    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-4275 hsa-miR-1297 hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidAPCDD1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APCD1_HUMAN, Q8J025: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus2
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA--

    Find genes that share ontologies with APCDD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APCDD1
    Interactions:

        GeneGlobe Interaction Network for APCDD1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for APCDD1 (Q8J0253 ENSP000003474334) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    ENSG00000235712P287023I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IMP--
    GO:0016055Wnt signaling pathway IEA--
    GO:0030178negative regulation of Wnt signaling pathway IDA--
    GO:0043615astrocyte cell migration IEA--

    Find genes that share ontologies with APCDD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APCDD1 (APCD1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APCDD1 gene: 
    NM_153000.4  

    Unigene Cluster for APCDD1:

    Adenomatosis polyposis coli down-regulated 1
    Hs.293274  [show with all ESTs]
    Unigene Representative Sequence: AB104887
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355285(uc002kom.4) ENST00000423585 ENST00000582723 ENST00000578882
    ENST00000584596 ENST00000579685
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate APCDD1 (see all 25):
    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-4275 hsa-miR-1297 hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidAPCDD1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat APCDD1
      QuantiFast Probe-based Assays in human, mouse, rat APCDD1

    Additional mRNA sequence: 

    AB056722.1 AB104887.1 AF461902.1 AK300743.1 AK303076.1 AL110199.1 BC053324.1 

    10 DOTS entries:

    DT.100025899  DT.216150  DT.100787241  DT.97856565  DT.95304823  DT.100787240  DT.100787245  DT.95304888 
    DT.100673995  DT.40119353 

    Selected AceView cDNA sequences (see all 183):

    AA228006 AA361091 AL110199 BM676256 BF475830 AI801268 AI803839 AI554474 
    AA513457 AA358448 BM709350 AI123010 BM715696 AI081626 CD516082 AI361531 
    AA425235 BM672131 BG677848 CD517878 AI093946 BM690821 BX381158 BU689413 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for APCDD1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                                  -     -     -                                 
    SP2:                                                  -           -                                 
    SP3:                                      -     -     -     -     -     -                           
    SP4:                          -     -     -     -     -     -     -                                 
    SP5:                          -                       -     -     -                                 


    ECgene alternative splicing isoforms for APCDD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APCDD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAGCAAGG
    APCDD1 Expression
    About this image


    APCDD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipose
             HyStem+BMP4-induced 7SMOO32 cells
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Node Cells Atrioventricular Node
             Outflow Tract
    APCDD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APCDD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.293274

    UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025
    Tissue specificity: Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung,
    liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and
    dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal
    papilla, the matrix, and the hair shaft (at protein level)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for APCDD1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apcdd11 , 5 adenomatosis polyposis coli down-regulated 11, 5 85.54(n)1
    91.83(a)1
      18 (35.95 cM)5
    4945041  NM_133237.31  NP_573500.21 
     629223275 
    chicken
    (Gallus gallus)
    Aves APCDD11 adenomatosis polyposis coli down-regulated 1 78.65(n)
    84.96(a)
      426765  NM_001012941.2  NP_001012959.1 
    lizard
    (Anolis carolinensis)
    Reptilia APCDD16
    adenomatosis polyposis coli down-regulated 1
    82(a)
    1 ↔ 1
    GL343319.1(812084-855750)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA986574.12   -- 75.32(n)    CA986574.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003326391 protein APCDD1-like 65.3(n)
    62.5(a)
      100332639  XM_002662079.1  XP_002662125.1 


    ENSEMBL Gene Tree for APCDD1 (if available)
    TreeFam Gene Tree for APCDD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APCDD1 gene
    APCDD1L2  
    Selected SIMAP similar genes for APCDD1 using alignment to 5 protein entries:     APCD1_HUMAN (see all proteins) (see all similar genes):
    OK/SW-cl.41    PACSIN2    ZNF670    LRRC37A3    KIAA1651    DNAPTP3
    CCT3    PPP2R1A    ZNF195    AREL1    FAM138C    FP6651
    PLA2G15    C14orf178    FLJ20555    C14orf2    APCDD1L    UTY

    Find genes that share paralogs with APCDD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APCDD1 (see all 867)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0634974
    Hypotrichosis 1 (HYPT1)4--see VAR_0634972 L R mis40--------
    rs1169028841,2
    C,F--10452945(+) ACAAAG/ATCAGG 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1866241851,2
    C--10452996(+) GCCTGC/TGCTCA 1 -- us2k10--------
    rs1421976571,2
    --10453038(+) CACACA/TGGTAT 1 -- us2k10--------
    rs1925914831,2
    C--10453043(+) AGGTAA/TTCTTT 1 -- us2k10--------
    rs1459058021,2
    --10453064(+) ATTTGC/TAAACA 1 -- us2k10--------
    rs1847805391,2
    --10453124(+) TCTTAC/TGATCC 1 -- us2k10--------
    rs285322191,2
    C,F,H--10453143(+) AATGAT/CGGAAA 1 -- us2k19Minor allele frequency- C:0.04NS NA WA 1014
    rs1481305941,2
    --10453267(+) CAAATA/GTATTC 1 -- us2k10--------
    rs767001191,2
    F--10453360(+) TTCAAA/TGGGGC 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for APCDD1 (10454625 - 10489945 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for APCDD1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2443287CNV Deletion19546169
    esv2716787CNV Deletion23290073
    esv2716788CNV Deletion23290073
    esv1968192CNV Deletion18987734
    esv3055CNV Deletion18987735
    esv988512CNV Deletion20482838
    esv2716786CNV Deletion23290073
    esv5818CNV Loss19470904
    nsv458026CNV Loss19166990
    nsv131991CNV Loss16902084

    Human Gene Mutation Database (HGMD): APCDD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APCDD1
    DNA2.0 Custom Variant and Variant Library Synthesis for APCDD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607479   
    OMIM disorders: 605389  
    UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025
  • Hypotrichosis 1 (HYPT1) [MIM:605389]: A rare form of non-syndromic hereditary hypotrichosis without
    characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and
    thinning of the hair shaft start during early childhood and progress with age. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 5 diseases for APCDD1:    
    About MalaCards
    hypotrichosis 1    hypotrichosis simplex    hypotrichosis    edwards syndrome
    hypotrichosis 11


    Find genes that share disorders with APCDD1           About GenesLikeMe

    Genetic Association Database (GAD): APCDD1
    Human Genome Epidemiology (HuGE) Navigator: APCDD1 (3 documents)

    Export disorders for APCDD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APCDD1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with APCDD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel human gene, APCDD1, as a direct target of the b- catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. (PubMed id 12384519)1, 2, 3 Takahashi M.... Nakamura Y. (Cancer Res. 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. (PubMed id 20393562)1, 2 Shimomura Y....Christiano A.M. (Nature 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 23934736)1 Yu B....Boerwinkle E. (Genet. Epidemiol. 2013)
    7. A recurrent mutation in the APCDD1 gene responsible for hereditary hypotrichosis simplex in a large Chinese family. (PubMed id 22512811)1 Li M....Yao Z. (Br. J. Dermatol. 2012)
    8. The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations. (PubMed id 21866343)1 Ahn M.J....Park K. (Hum. Genet. 2012)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    10. Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (J. Bone Miner. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 147495 HGNC: 15718 AceView: APCDD1 Ensembl:ENSG00000154856 euGenes: HUgn147495
    ECgene: APCDD1 H-InvDB: APCDD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APCDD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APCDD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APCDD1 gene:
    Search GeneIP for patents involving APCDD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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