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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APCDD1 Gene

protein-coding   GIFtS: 52
GCID: GC18P010444

Adenomatosis Polyposis Coli Down-Regulated 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenomatosis Polyposis Coli Down-Regulated 11 2     HHS2
Adenomatosis Polyposis Coli Down-Regulated 1 Protein2 3     HTS2
DRAPC12 3     Hypoptrichosis Simplex2
B73232     Protein APCDD12

External Ids:    HGNC: 157181   Entrez Gene: 1474952   Ensembl: ENSG000001548567   OMIM: 6074795   UniProtKB: Q8J0253   

Export aliases for APCDD1 gene to outside databases

Previous GC identifers: GC00U991017 GC18P010511


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APCDD1 Gene:
This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with
hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal
carcinogenesis.(provided by RefSeq, Sep 2010)

GeneCards Summary for APCDD1 Gene: 
APCDD1 (adenomatosis polyposis coli down-regulated 1) is a protein-coding gene. Diseases associated with APCDD1 include hypotrichosis simplex, and edwards syndrome. GO annotations related to this gene include Wnt-protein binding. An important paralog of this gene is APCDD1L.

UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025
Function: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and
functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in
colorectal tumorigenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010859.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APCDD1 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for APCDD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APCDD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.22   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.21

APCDD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APCDD1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P010444:  view genomic region     (about GC identifiers)

Start:
10,454,625 bp from pter      End:
10,488,698 bp from pter
Size:
34,074 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025 (See protein sequence)
Recommended Name: Protein APCDD1 precursor  
Size: 514 amino acids; 58797 Da
Subunit: Homodimer. Interacts with LRP5 and WNT3A
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAQ04816.1; Type=Frameshift; Positions=133; Sequence=BAG62412.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAG64192.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: B4DUQ0 B4DZT0 Q71M25

Explore the universe of human proteins at neXtProt for APCDD1: NX_Q8J025

Explore proteomics data for APCDD1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-Glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8J025

  • APCDD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APCDD1 Protein Expression
    REFSEQ proteins: NP_694545.1  
    ENSEMBL proteins: 
     ENSP00000347433   ENSP00000404930   ENSP00000463110   ENSP00000463104   ENSP00000464649  

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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for APCDD1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA--

    APCDD1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8J025

    UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025
    Similarity: Belongs to the APCDD1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APCD1_HUMAN, Q8J025
    Function: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and
    functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in
    colorectal tumorigenesis
    Induction: Target gene of the Wnt/Beta-catenin pathway, transcriptionally regulated by the CTNNB1/TF7L2 complex

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017147Wnt-protein binding IDA--
         
    APCDD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Apcdd1):
     no phenotypic analysis 

    APCDD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Apcdd1tm1.1Hsav for APCDD1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for APCDD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APCDD1

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    miRNA
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    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-4275 hsa-miR-1297 hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidAPCDD1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APCDD1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/8 Interacting proteins for APCDD1 (Q8J0253 ENSP000003474334) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    ENSG00000235712P287023I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IMP--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030178negative regulation of Wnt receptor signaling pathway IDA--
    GO:0043615astrocyte cell migration IEA--

    APCDD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APCDD1 (APCD1)

    Search CenterWatch for drugs/clinical trials and news about APCDD1 / APCD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APCDD1 gene: 
    NM_153000.4  

    Unigene Cluster for APCDD1:

    Adenomatosis polyposis coli down-regulated 1
    Hs.293274  [show with all ESTs]
    Unigene Representative Sequence: AB104887
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355285(uc002kom.4) ENST00000423585 ENST00000582723 ENST00000578882
    ENST00000584596 ENST00000579685
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APCDD1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate APCDD1 (see all 25):
    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-4275 hsa-miR-1297 hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidAPCDD1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB056722.1 AB104887.1 AF461902.1 AK300743.1 AK303076.1 AL110199.1 BC053324.1 

    10 DOTS entries:

    DT.100025899  DT.216150  DT.100787241  DT.97856565  DT.95304823  DT.100787240  DT.100787245  DT.95304888 
    DT.100673995  DT.40119353 

    24/183 AceView cDNA sequences (see all 183):

    BM672131 AI123010 AI093946 AI081626 BF475830 AA513457 AL110199 AI225114 
    CD516082 BM715696 BF830914 AI801268 AI554474 BX381158 AA228006 BQ889156 
    BQ672506 BQ673164 CR592932 BM690821 AA361091 BM709350 AI803839 AI361531 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for APCDD1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                                  -     -     -                                 
    SP2:                                                  -           -                                 
    SP3:                                      -     -     -     -     -     -                           
    SP4:                          -     -     -     -     -     -     -                                 
    SP5:                          -                       -     -     -                                 


    ECgene alternative splicing isoforms for APCDD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APCDD1 expression in normal human tissues (normalized intensities)      APCDD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAGCAAGG
    APCDD1 Expression
    About this image


    APCDD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Fibroblast
             Human Gingival Fibroblasts (HGF)   
     
     Dermis (Uncategorized)    fully expand to see all 4 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Atrioventricular Node Cells Atrioventricular Node
             Outflow Tract
             mouse/organ system/cardiovascular system   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier

    See APCDD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APCDD1

    SOURCE GeneReport for Unigene cluster: Hs.293274

    UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025
    Tissue specificity: Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung,
    liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and
    dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal
    papilla, the matrix, and the hair shaft (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for APCDD1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apcdd11 , 5 adenomatosis polyposis coli down-regulated 11, 5 85.54(n)1
    91.83(a)1
      18 (35.95 cM)5
    4945041  NM_133237.31  NP_573500.21 
     629223275 
    chicken
    (Gallus gallus)
    Aves APCDD11 adenomatosis polyposis coli down-regulated 1 78.78(n)
    85.27(a)
      426765  NM_001012941.2  NP_001012959.1 
    lizard
    (Anolis carolinensis)
    Reptilia APCDD16
    adenomatosis polyposis coli down-regulated 1
    83(a)
    1 ↔ 1
    GL343319.1(812084-855750)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA986574.12   -- 75.32(n)    CA986574.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003326391 protein APCDD1-like 65.22(n)
    62.5(a)
      100332639  XM_002662079.1  XP_002662125.1 


    ENSEMBL Gene Tree for APCDD1 (if available)
    TreeFam Gene Tree for APCDD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APCDD1 gene
    APCDD1L2  
    18/25 SIMAP similar genes for APCDD1 using alignment to 4 protein entries:     APCD1_HUMAN (see all proteins) (see all similar genes):
    LOC100996577    OK/SW-cl.41    PACSIN2    ZNF670    LRRC37A3    KIAA1651
    DNAPTP3    CCT3    PPP2R1A    ZNF195    AREL1    FAM138A
    FAM138B    FAM138C    FAM138F    FP6651    PLA2G15    C14orf178

    APCDD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/867 SNPs in APCDD1 are shown (see all 867)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0634974
    Hypotrichosis 1 (HYPT1)4--see VAR_0634972 L R mis40--------
    rs1169028841,2
    C,F--10452945(+) ACAAAG/ATCAGG 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1866241851,2
    C--10452996(+) GCCTGC/TGCTCA 1 -- us2k10--------
    rs1421976571,2
    --10453038(+) CACACA/TGGTAT 1 -- us2k10--------
    rs1925914831,2
    C--10453043(+) AGGTAA/TTCTTT 1 -- us2k10--------
    rs1459058021,2
    --10453064(+) ATTTGC/TAAACA 1 -- us2k10--------
    rs1847805391,2
    --10453124(+) TCTTAC/TGATCC 1 -- us2k10--------
    rs285322191,2
    C,F,H--10453143(+) AATGAT/CGGAAA 1 -- us2k19Minor allele frequency- C:0.04NS NA WA 1014
    rs1481305941,2
    --10453267(+) CAAATA/GTATTC 1 -- us2k10--------
    rs767001191,2
    F--10453360(+) TTCAAA/TGGGGC 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for APCDD1 (10454625 - 10488698 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for APCDD1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2443287CNV Deletion19546169
    esv2716787CNV Deletion23290073
    esv2716788CNV Deletion23290073
    esv1968192CNV Deletion18987734
    esv3055CNV Deletion18987735
    esv988512CNV Deletion20482838
    esv2716786CNV Deletion23290073
    esv5818CNV Loss19470904
    nsv458026CNV Loss19166990
    nsv131991CNV Loss16902084


    Human Gene Mutation Database (HGMD): APCDD1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607479    OMIM disorders: --

    UniProtKB/Swiss-Prot: APCD1_HUMAN, Q8J025
  • Hypotrichosis 1 (HYPT1) [MIM:605389]: A rare form of non-syndromic hereditary hypotrichosis without
    characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and
    thinning of the hair shaft start during early childhood and progress with age. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 5 diseases for APCDD1:    About MalaCards
    hypotrichosis simplex    edwards syndrome    hypotrichosis    lung cancer
    prostatitis


    APCDD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): APCDD1
    Human Genome Epidemiology (HuGE) Navigator: APCDD1 (3 documents)

    Export disorders for APCDD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APCDD1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with APCDD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel human gene, APCDD1, as a direct target of the b- catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. (PubMed id 12384519)1, 2, 3 Takahashi M.... Nakamura Y. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. (PubMed id 20393562)1, 2 Shimomura Y....Christiano A.M. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    6. A recurrent mutation in the APCDD1 gene responsible fo r hereditary hypotrichosis simplex in a large Chinese family. (PubMed id 22512811)1 Li M....Yao Z. (2012)
    7. The 18p11.22 locus is associated with never smoker non -small cell lung cancer susceptibility in Korean populations. (PubMed id 21866343)1 Ahn M.J....Park K. (2012)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    9. Replication of previous genome-wide association studi es of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (2010)
    10. Systematic identification of placental epigenetic sig natures for the noninvasive prenatal detection of Edwards syndrome. (PubMed id 21152411)1 Tsui D.W....Chim S.S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147495 HGNC: 15718 AceView: APCDD1 Ensembl:ENSG00000154856 euGenes: HUgn147495
    ECgene: APCDD1 H-InvDB: APCDD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APCDD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APCDD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APCDD1 gene:
    Search GeneIP for patents involving APCDD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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