Aliases for APCDD1 Gene
External Ids for APCDD1 Gene
This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]
GeneCards Summary for APCDD1 Gene
APCDD1 (Adenomatosis Polyposis Coli Down-Regulated 1) is a Protein Coding gene. Diseases associated with APCDD1 include hypotrichosis 1 and hypotrichosis simplex. GO annotations related to this gene include Wnt-protein binding. An important paralog of this gene is APCDD1L.
UniProtKB/Swiss-Prot for APCDD1 Gene
Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.