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Aliases for APC2 Gene

Aliases for APC2 Gene

  • Adenomatosis Polyposis Coli 2 2 3
  • APCL 3 4 6
  • Adenomatous Polyposis Coli Like 2 3
  • Adenomatous Polyposis Coli Protein-Like 4
  • Adenomatous Polyposis Coli Protein 2 3
  • APC-Like 4

External Ids for APC2 Gene

Previous GeneCards Identifiers for APC2 Gene

  • GC09U990134
  • GC19P001403
  • GC19P001397
  • GC19P001224

Summaries for APC2 Gene

GeneCards Summary for APC2 Gene

APC2 (Adenomatosis Polyposis Coli 2) is a Protein Coding gene. Diseases associated with APC2 include adenomatous polyposis coli. Among its related pathways are Regulation of actin cytoskeleton and Pathways in cancer. GO annotations related to this gene include microtubule binding and beta-catenin binding. An important paralog of this gene is ENSG00000258864.

UniProtKB/Swiss-Prot for APC2 Gene

  • Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APC2 Gene

Genomics for APC2 Gene

Regulatory Elements for APC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APC2 Gene

Start:
1,446,270 bp from pter
End:
1,473,244 bp from pter
Size:
26,975 bases
Orientation:
Plus strand

Genomic View for APC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APC2 Gene

Proteins for APC2 Gene

  • Protein details for APC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95996-APC2_HUMAN
    Recommended name:
    Adenomatous polyposis coli protein 2
    Protein Accession:
    O95996
    Secondary Accessions:
    • Q05BW4
    • Q9UBZ1
    • Q9UEM8
    • Q9UQJ8
    • Q9UQJ9
    • Q9Y632

    Protein attributes for APC2 Gene

    Size:
    2303 amino acids
    Molecular mass:
    243949 Da
    Quaternary structure:
    • Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2.
    SequenceCaution:
    • Sequence=AAD28183.1; Type=Frameshift; Positions=1322, 1338; Evidence={ECO:0000305}; Sequence=AAF01784.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=CAA10317.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB61207.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for APC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APC2 Gene

Proteomics data for APC2 Gene at MOPED

Post-translational modifications for APC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APC2 Gene

No data available for DME Specific Peptides for APC2 Gene

Domains for APC2 Gene

Gene Families for APC2 Gene

HGNC:
  • ARMC :Armadillo repeat containing

Protein Domains for APC2 Gene

Suggested Antigen Peptide Sequences for APC2 Gene

Graphical View of Domain Structure for InterPro Entry

O95996

UniProtKB/Swiss-Prot:

APC2_HUMAN :
  • O95996
Family:
  • Belongs to the adenomatous polyposis coli (APC) family.
Similarity:
  • Contains 6 ARM repeats.
genes like me logo Genes that share domains with APC2: view

Function for APC2 Gene

Molecular function for APC2 Gene

UniProtKB/Swiss-Prot Function:
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.

Gene Ontology (GO) - Molecular Function for APC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 10644998
GO:0008013 beta-catenin binding IDA 9823329
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with APC2: view
genes like me logo Genes that share phenotypes with APC2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APC2 Gene

Localization for APC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APC2 Gene

Cytoplasm, cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with actin filaments and the microtubule network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APC2 Gene COMPARTMENTS Subcellular localization image for APC2 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
plasma membrane 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for APC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA 11691822
GO:0005794 Golgi apparatus IDA 11691822
GO:0005881 colocalizes_with cytoplasmic microtubule IDA 10644998
GO:0005884 actin filament IDA 11691822
genes like me logo Genes that share ontologies with APC2: view

Pathways for APC2 Gene

genes like me logo Genes that share pathways with APC2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for APC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway --
GO:0035414 negative regulation of catenin import into nucleus IDA 10021369
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 10021369
genes like me logo Genes that share ontologies with APC2: view

Transcripts for APC2 Gene

Unigene Clusters for APC2 Gene

Adenomatosis polyposis coli 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APC2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1:
SP2:
SP3: - - - - - - - - - - -
SP4: - - -
SP5: - -

Relevant External Links for APC2 Gene

GeneLoc Exon Structure for
APC2
ECgene alternative splicing isoforms for
APC2

Expression for APC2 Gene

mRNA expression in normal human tissues for APC2 Gene

mRNA differential expression in normal tissues according to GTEx for APC2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.4), Brain - Cerebellar Hemisphere (4.4), Brain - Cerebellum (4.3), and Brain - Cortex (4.2).

Protein differential expression in normal tissues for APC2 Gene

This gene is overexpressed in Serum (41.4), Plasma (13.9), and Peripheral blood mononuclear cells (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APC2 Gene

SOURCE GeneReport for Unigene cluster for APC2 Gene Hs.446376

mRNA Expression by UniProt/SwissProt for APC2 Gene

O95996-APC2_HUMAN
Tissue specificity: Widely expressed (at protein level). Specifically expressed in the CNS.
genes like me logo Genes that share expressions with APC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for APC2 Gene

Orthologs for APC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for APC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APC2 35
  • 82.86 (n)
  • 84.98 (a)
APC2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APC2 35
  • 84.16 (n)
  • 83.95 (a)
APC2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apc2 35
  • 78.18 (n)
  • 82.69 (a)
Apc2 16
Apc2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APC2 35
  • 98.91 (n)
  • 99.12 (a)
APC2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apc2 35
  • 78.44 (n)
  • 83.04 (a)
oppossum
(Monodelphis domestica)
Mammalia APC2 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves APC2 35
  • 70.72 (n)
  • 66.1 (a)
APC2 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APC2 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apc2 35
  • 56.19 (n)
  • 56.93 (a)
zebrafish
(Danio rerio)
Actinopterygii apc2 35
  • 56.48 (n)
  • 56.27 (a)
apc2 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Apc 36
  • 18 (a)
ManyToMany
Apc2 36
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea apr-1 36
  • 20 (a)
OneToMany
Species with no ortholog for APC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APC2 Gene

ENSEMBL:
Gene Tree for APC2 (if available)
TreeFam:
Gene Tree for APC2 (if available)

Paralogs for APC2 Gene

Paralogs for APC2 Gene

Selected SIMAP similar genes for APC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with APC2: view

Variants for APC2 Gene

Sequence variations from dbSNP and Humsavar for APC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12005 -- 1,457,876(+) TTCAG(A/G)CCTGG intron-variant
rs166452 -- 1,469,531(+) CACCA(C/G)CTCCG reference, missense
rs166453 -- 1,469,372(+) gggcg(C/T)ctcgc reference, missense
rs182043 -- 1,468,329(+) TCGGA(A/C/G/T)CGGGC missense, reference, synonymous-codon
rs265272 -- 1,467,771(+) GGGGA(A/C/G/T)GGGGC missense, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for APC2 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv1055e1 CNV Complex 17122850
dgv3580n71 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
dgv3598n71 CNV Loss 21882294
nsv910491 CNV Gain+Loss 21882294
nsv910492 CNV Loss 21882294
dgv3599n71 CNV Loss 21882294
essv18235 CNV CNV 17122850
nsv833705 CNV Loss 17160897
nsv910499 CNV Loss 21882294
dgv3600n71 CNV Loss 21882294
dgv3601n71 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
nsv910507 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
nsv817811 CNV Loss 17921354
nsv470105 CNV Gain 18288195
dgv3604n71 CNV Gain+Loss 21882294
dgv3605n71 CNV Loss 21882294
nsv910517 CNV Loss 21882294
esv25963 CNV Loss 19812545

Relevant External Links for APC2 Gene

HapMap Linkage Disequilibrium report
APC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APC2 Gene

Disorders for APC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for APC2 Gene in MalaCards »

(1) Diseases for APC2 Gene including...

(3) Novoseek inferred disease relationships for APC2 Gene

Disease -log(P) Hits PubMed IDs
familial adenomatous polyposis 79.6 5
tumors 18.3 5
cancer 0 2

Relevant External Links for APC2

Genetic Association Database (GAD)
APC2
Human Genome Epidemiology (HuGE) Navigator
APC2
genes like me logo Genes that share disorders with APC2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for APC2 Gene

Publications for APC2 Gene

  1. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. (PMID: 9823329) Nakagawa H. … Nakamura Y. (Cancer Res. 1998) 2 3 4 23
  2. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. (PMID: 10021369) van Es J.H. … Clevers H. (Curr. Biol. 1999) 2 3 4 23
  3. APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. (PMID: 10646860) Nakagawa H. … Nakamura Y. (Cancer Res. 2000) 3 4 23
  4. Human APC2 localization and allelic imbalance. (PMID: 11691822) Jarrett C.R. … Byers S.W. (Cancer Res. 2001) 3 4 23
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for APC2 Gene

Sources for APC2 Gene

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