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APC2 Gene

protein-coding   GIFtS: 52
GCID: GC19P001450

Adenomatosis Polyposis Coli 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenomatosis Polyposis Coli 21 2
APCL2 3 5
Adenomatous Polyposis Coli Like1 2
Adenomatous Polyposis Coli Protein 22
APC-like3
Adenomatous Polyposis Coli Protein-Like3

External Ids:    HGNC: 240361   Entrez Gene: 102972   Ensembl: ENSG000001152667   OMIM: 6120345   UniProtKB: O959963   

Export aliases for APC2 gene to outside databases

Previous GC identifers: GC09U990134 GC19P001403 GC19P001397 GC19P001224


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for APC2 Gene:
APC2 (adenomatosis polyposis coli 2) is a protein-coding gene. GO annotations related to this gene include microtubule binding and beta-catenin binding. An important paralog of this gene is APC.

UniProtKB/Swiss-Prot: APC2_HUMAN, O95996
Function: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt
signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APC2 gene promoter:
         NF-1   NF-1/L   p53   NRSF form 1   NRSF form 2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): APC2 promoter sequence
   Search Chromatin IP Primers for APC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

APC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APC2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001450:  view genomic region     (about GC identifiers)

Start:
1,446,300 bp from pter      End:
1,473,243 bp from pter
Size:
26,944 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: APC2_HUMAN, O95996 (See protein sequence)
Recommended Name: Adenomatous polyposis coli protein 2  
Size: 2303 amino acids; 243949 Da
Subunit: Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly
with AXIN2
Developmental stage: Expressed in fetal brain
Sequence caution: Sequence=AAD28183.1; Type=Frameshift; Positions=1322, 1338; Sequence=AAF01784.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=CAA10317.1; Type=Erroneous initiation;
Sequence=CAB61207.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence;
Secondary accessions: Q05BW4 Q9UBZ1 Q9UEM8 Q9UQJ8 Q9UQJ9 Q9Y632
Alternative splicing: 3 isoforms:  O95996-1   O95996-2   O95996-3   

Explore the universe of human proteins at neXtProt for APC2: NX_O95996

Explore proteomics data for APC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See APC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005874.1  
    ENSEMBL proteins: 
     ENSP00000466803   ENSP00000467073   ENSP00000466173   ENSP00000442954   ENSP00000468199  
     ENSP00000233607   ENSP00000238483  

    APC2 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for APC2

     
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    antibodies-online peptides for APC2

    APC2 Antibody Products:

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    antibodies-online antibodies for APC2 (33 products) 

    APC2 Assay Products:

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    Cloud-Clone Corp. ELISAs for APC2
    Cloud-Clone Corp. CLIAs for APC2
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    antibodies-online kits for APC2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing

    Selected InterPro protein domains (see all 9):
     IPR011989 ARM-like
     IPR009224 SAMP
     IPR000225 Armadillo
     IPR026831 APC_dom
     IPR026837 APC2

    Graphical View of Domain Structure for InterPro Entry O95996

    ProtoNet protein and cluster: O95996

    UniProtKB/Swiss-Prot: APC2_HUMAN, O95996
    Similarity: Belongs to the adenomatous polyposis coli (APC) family
    Similarity: Contains 6 ARM repeats


    Find genes that share domains with APC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC2_HUMAN, O95996
    Function: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt
    signaling

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI10644998
    GO:0008013beta-catenin binding IDA9823329
    GO:0008017microtubule binding IEA--
         
    Find genes that share ontologies with APC2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for APC2:
     Increased cell number in G2M,   Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Apc2):
     behavior/neurological  cellular  growth/size/body  nervous system  reproductive system 

    Find genes that share phenotypes with APC2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for APC2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat APC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APC2 (see all 12):
    hsa-miR-98 hsa-let-7d hsa-miR-2110 hsa-miR-219-5p hsa-let-7c hsa-let-7i hsa-miR-3918 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidAPC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for APC2
    Predesigned siRNA for gene silencing in human, mouse, rat APC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for APC2

    Clone
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    OriGene clones in human, mouse for APC2 (see all 5)
    OriGene ORF clones in mouse, rat for APC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: APC2 (NM_003083)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APC2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat APC2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for APC2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APC2_HUMAN, O95996: Cytoplasm, cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic
    side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with actin filaments and the
    microtubule network
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    plasma membrane5
    nucleus3
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IDA11691822
    GO:0005794Golgi apparatus IDA11691822
    GO:0005881cytoplasmic microtubule IMP11691822
    GO:0005884actin filament IDA11691822

    Find genes that share ontologies with APC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APC2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Endometrial cancer
    Endometrial cancer0.45
    Colorectal cancer0.42
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    3Basal cell carcinoma
    Basal cell carcinoma0.43
    4Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    5Pathways in cancer
    Pathways in cancer


    Find genes that share SuperPaths with APC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    Selected Kegg Pathways  (Kegg details for APC2) (see all 9):
        Wnt signaling pathway
    Hippo signaling pathway
    Regulation of actin cytoskeleton
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including APC2: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for APC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for APC2 (O959961, 3 ENSP000002336074) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPRE1Q156911, 3, ENSP000003647214EBI-1053045,EBI-1004115 I2D: score=3 STRING: ENSP00000364721
    MAPRE3Q9UPY81, 3, ENSP000002331214EBI-1053045,EBI-726739 I2D: score=3 STRING: ENSP00000233121
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    ANAPC1Q9H1A43, ENSP000003391094I2D: score=1 STRING: ENSP00000339109
    ANAPC11Q9NYG53, ENSP000003499574I2D: score=1 STRING: ENSP00000349957
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055Wnt signaling pathway IEA--
    GO:0030178negative regulation of Wnt signaling pathway ----
    GO:0035414negative regulation of catenin import into nucleus IDA10021369
    GO:0090090negative regulation of canonical Wnt signaling pathway IDA10021369

    Find genes that share ontologies with APC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APC2 gene: 
    NM_005883.2  

    Unigene Cluster for APC2:

    Adenomatosis polyposis coli 2
    Hs.446376  [show with all ESTs]
    Unigene Representative Sequence: NM_005883
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587869 ENST00000590469 ENST00000590877 ENST00000593146 ENST00000535453(uc002lst.1 uc002lsu.1)
    ENST00000587149 ENST00000233607(uc002lsr.1 uc002lss.1) ENST00000238483

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat APC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APC2 (see all 12):
    hsa-miR-98 hsa-let-7d hsa-miR-2110 hsa-miR-219-5p hsa-let-7c hsa-let-7i hsa-miR-3918 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidAPC2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat APC2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: APC2 (NM_003083)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APC2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat APC2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for APC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APC2
      QuantiTect SYBR Green Assays in human, mouse, rat APC2
      QuantiFast Probe-based Assays in human, mouse, rat APC2

    Additional mRNA sequence: 

    AF110334.1 AF128222.1 AJ012652.1 AL078616.1 BC020381.1 BC032573.1 

    6 DOTS entries:

    DT.115077  DT.100777823  DT.40129739  DT.99944120  DT.95149695  DT.95270719 

    Selected AceView cDNA sequences (see all 158):

    BG059542 AI568664 BC032573 AI435262 BM711306 BX446084 AA491233 AI074529 
    BM702175 BM679460 AA338646 BX424479 AI880344 AW339237 AI566954 BI554178 
    CD673053 BG912351 BE220485 BI757693 CR600190 BX281510 AI934453 AI948422 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for APC2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:        -     -     -     -                             -     -     -     -     -     -     -                                             
    SP4:              -     -     -                                                                                                               
    SP5:                    -     -                                                                                                               


    ECgene alternative splicing isoforms for APC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCTCCCGA
    APC2 Expression
    About this image

    APC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446376

    UniProtKB/Swiss-Prot: APC2_HUMAN, O95996
    Tissue specificity: Widely expressed (at protein level). Specifically expressed in the CNS

        Pathway & Disease-focused RT2 Profiler PCR Array including APC2: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APC2
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    QuantiFast Probe-based Assays in human, mouse, rat APC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for APC2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apc21 , 5 adenomatosis polyposis coli 21, 5 78.18(n)1
    82.69(a)1
      10 (39.72 cM)5
    238051  NM_011789.21  NP_035919.21 
     802959775 
    chicken
    (Gallus gallus)
    Aves APC21 adenomatosis polyposis coli 2 70.72(n)
    66.1(a)
      429363  NM_001171771.1  NP_001165242.1 
    lizard
    (Anolis carolinensis)
    Reptilia APC26
    adenomatosis polyposis coli 2
    49(a)
    1 ↔ 1
    GL344458.1(12108-27729)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia apc21 adenomatosis polyposis coli 2 56.19(n)
    56.93(a)
      100487473  XM_002941120.2  XP_002941166.2 
    zebrafish
    (Danio rerio)
    Actinopterygii apc21 adenomatosis polyposis coli 2 56.48(n)
    56.27(a)
      565771  XM_689041.6  XP_694133.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Apc26
    Apc6
    APC-like
    31(a)
    18(a)
    many ↔ many
    many ↔ many
    3R(19989690-19994041)
    3R(24658022-24670372)
    worm
    (Caenorhabditis elegans)
    Secernentea apr-16
    Protein APR-1, isoform b (apr-1) mRNA, complete cd...
    20(a)
    1 → many
    I(8050043-8055474) WBGene00000156


    ENSEMBL Gene Tree for APC2 (if available)
    TreeFam Gene Tree for APC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APC2 gene
    APC2  ENSG000002588642  
    1 SIMAP similar gene for APC2 using alignment to 5 protein entries:     APC2_HUMAN (see all proteins):
    APC

    Find genes that share paralogs with APC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APC2 (see all 747)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0377044
    A breast cancer sample4--see VAR_0377042 G S mis40--------
    VAR_0377034
    A breast cancer sample4--see VAR_0377032 A S mis40--------
    rs1131935851,2
    C,F--1448171(+) ACCACG/ACGCCC 1 -- us2k12Minor allele frequency- A:0.05NA 122
    rs1504881411,2
    --1448172(+) CCACGC/TGCCCT 1 -- us2k10--------
    rs48079281,2
    C,F,A,H--1448180(+) CCTACC/TCCATG 1 -- us2k122Minor allele frequency- T:0.29NS EA NA WA CSA 2348
    rs1383003271,2
    --1448243(+) TGGAAC/TGCCTC 1 -- us2k10--------
    rs1427720051,2
    --1448387(+) TTAAAA/CATACA 1 -- us2k10--------
    rs1829310551,2
    --1448521(+) GCCTGA/GGGGAC 1 -- us2k10--------
    rs2652991,2
    F--1448594(+) aatccC/Gagcac 1 -- us2k1 tfbs32Minor allele frequency- G:0.00NA 4
    rs1998071061,2
    C--1448677(+) AAAAA-/ATACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for APC2 (1446300 - 1473243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for APC2 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3589n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv910499CNV Loss21882294
    nsv910517CNV Loss21882294
    dgv3596n71CNV Loss21882294
    dgv3601n71CNV Loss21882294
    nsv910492CNV Loss21882294
    nsv910507CNV Loss21882294
    dgv3603n71CNV Loss21882294
    dgv3580n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APC2
    DNA2.0 Custom Variant and Variant Library Synthesis for APC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612034    OMIM disorders: --


    Find genes that share disorders with APC2           About GenesLikeMe

    3 Novoseek inferred disease relationships for APC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 79.6 6 10646860 (2), 15018807 (1), 9823329 (1), 10021369 (1)
    tumors 18.3 7 10646860 (2), 11691822 (1), 15018807 (1), 9823329 (1)
    cancer 0 2 11691822 (1), 10021369 (1)

    Genetic Association Database (GAD): APC2
    Human Genome Epidemiology (HuGE) Navigator: APC2 (6 documents)

    Export disorders for APC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APC2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with APC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. (PubMed id 9823329)1, 2, 3, 9 Nakagawa H.... Nakamura Y. (Cancer Res. 1998)
    2. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. (PubMed id 10021369)1, 2, 3, 9 van Es J.H.... Clevers H. (Curr. Biol. 1999)
    3. Human APC2 localization and allelic imbalance. (PubMed id 11691822)1, 2, 9 Jarrett C.R.... Byers S.W. (Cancer Res. 2001)
    4. APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. (PubMed id 10646860)1, 2, 9 Nakagawa H.... Nakamura Y. (Cancer Res. 2000)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. (PubMed id 10644998)1, 2 Nakagawa H.... Nakamura Y. (Oncogene 2000)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation. (PubMed id 23840886)1 Schneikert J....Behrens J. (PLoS ONE 2013)
    9. Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization. (PubMed id 22513088)1 Roberts D.M....Peifer M. (Mol. Biol. Cell 2012)
    10. Modulation of K11-linkage formation by variable loop residues within UbcH5A. (PubMed id 21396940)1 Bosanac I....Kirkpatrick D.S. (J. Mol. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10297 HGNC: 24036 AceView: APC2 Ensembl:ENSG00000115266 euGenes: HUgn10297
    ECgene: APC2 Kegg: 10297 H-InvDB: APC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APC2 gene:
    Search GeneIP for patents involving APC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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