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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APC2 Gene

protein-coding   GIFtS: 53
GCID: GC19P001450

adenomatosis polyposis coli 2

 Explore 9 diseases affiliated with
APC2 via our new
 Human Malady Compendium 
Biological research products
for APC2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Adenomatosis Polyposis Coli 21 2
APCL1 2 3 5
Adenomatous Polyposis Coli Like2
Adenomatous Polyposis Coli Protein 22
APC-Like1
Adenomatous Polyposis Coli Protein-Like3

External Ids:    HGNC: 240361   Entrez Gene: 102972   Ensembl: ENSG000001152667   OMIM: 6120345   UniProtKB: O959963   

Export aliases for APC2 gene to outside databases

Previous GC identifers: GC09U990134 GC19P001403 GC19P001397 GC19P001224


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: APC2_HUMAN, O95996
Function: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APC2 gene promoter:
         NF-1   NF-1/L   p53   NRSF form 1   NRSF form 2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): APC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for APC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

APC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APC2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001450:  view genomic region     (about GC identifiers)

Start:
1,446,300 bp from pter      End:
1,473,243 bp from pter
Size:
26,944 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APC2_HUMAN, O95996 (See protein sequence)
Recommended Name: Adenomatous polyposis coli protein 2  
Size: 2303 amino acids; 243949 Da
Subunit: Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with
AXIN2
Subcellular location: Cytoplasm, cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with actin filaments and the microtubule
network
Developmental stage: Expressed in fetal brain
Sequence caution: Sequence=AAD28183.1; Type=Frameshift; Positions=1322, 1338; Sequence=AAF01784.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence; Sequence=CAA10317.1; Type=Erroneous initiation; Sequence=CAB61207.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence;
Secondary accessions: Q05BW4 Q9UBZ1 Q9UEM8 Q9UQJ8 Q9UQJ9 Q9Y632
Alternative splicing: 3 isoforms:  O95996-1   O95996-2   O95996-3   

Explore the universe of human proteins at neXtProt for APC2: NX_O95996

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95996

  • APC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005874.1  
    ENSEMBL proteins: 
     ENSP00000466803   ENSP00000467073   ENSP00000466173   ENSP00000442954   ENSP00000468199  
     ENSP00000233607   ENSP00000238483  

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    Uscn Proteins for APC2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IDA11691822
    GO:0005794Golgi apparatus IDA11691822
    GO:0005881cytoplasmic microtubule IMP11691822
    GO:0005884actin filament IDA11691822


    APC2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    APC2 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR026837 APC2
     IPR026818 Apc_fam
     IPR011989 ARM-like
     IPR009224 SAMP
     IPR000225 Armadillo

    Graphical View of Domain Structure for InterPro Entry O95996

    ProtoNet protein and cluster: O95996

    UniProtKB/Swiss-Prot: APC2_HUMAN, O95996
    Similarity: Belongs to the adenomatous polyposis coli (APC) family
    Similarity: Contains 6 ARM repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: APC2_HUMAN, O95996
    Function: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate APC2 (see all 12):
    hsa-miR-98 hsa-let-7d hsa-miR-2110 hsa-miR-219-5p hsa-let-7c hsa-let-7i hsa-miR-3918 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidAPC2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APC2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10646860
    GO:0008013beta-catenin binding IDA9823329
    GO:0008017microtubule binding IEA--


    APC2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for APC2:
     Increased cell number in G2M,   Increased gamma-H2AX phosphory 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Apc2):
     behavior/neurological  cellular  growth/size  nervous system  reproductive system 

    APC2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Endometrial cancer
    Endometrial cancer1.00
    Colorectal cancer0.42
    2Basal cell carcinoma
    Basal cell carcinoma1.00
    3Pathways in cancer
    Pathways in cancer1.00
    4Regulation of Actin Cytoskeleton
    Regulation of actin cytoskeleton0.58
    5Wnt Signaling Pathway
    Wnt signaling pathway0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    5/6         Kegg Pathways  (Kegg details for APC2) (see all 6):
        Wnt signaling pathway
    Regulation of actin cytoskeleton
    Pathways in cancer
    Colorectal cancer
    Endometrial cancer


    APC2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/98 Interacting proteins for APC2 (O959963 ENSP000002336074) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPRE1Q156913, ENSP000003647214I2D: score=3 STRING: ENSP00000364721
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    ANAPC1Q9H1A43, ENSP000003391094I2D: score=1 STRING: ENSP00000339109
    ANAPC11Q9NYG53, ENSP000003499574I2D: score=1 STRING: ENSP00000349957
    ANAPC5Q9UJX43, ENSP000002618194I2D: score=1 STRING: ENSP00000261819
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0035414negative regulation of catenin import into nucleus IDA10021369
    GO:0090090negative regulation of canonical Wnt receptor signaling pathway IDA10021369


    APC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APC2
    Search CenterWatch for drugs/clinical trials and news about APC2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APC2 gene: 
    NM_005883.2  

    Unigene Cluster for APC2:

    Adenomatosis polyposis coli 2
    Hs.446376  [show with all ESTs]
    Unigene Representative Sequence: NM_005883
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587869 ENST00000590469 ENST00000590877 ENST00000593146 ENST00000535453(uc002lst.1 uc002lsu.1)
    ENST00000587149 ENST00000233607(uc002lsr.1 uc002lss.1) ENST00000238483


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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APC2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate APC2 (see all 12):
    hsa-miR-98 hsa-let-7d hsa-miR-2110 hsa-miR-219-5p hsa-let-7c hsa-let-7i hsa-miR-3918 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidAPC2 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APC2

    Additional cDNA sequence: 

    AF110334.1 AF128222.1 AJ012652.1 AL078616.1 BC020381.1 BC032573.1 

    6 DOTS entries:

    DT.115077  DT.100777823  DT.40129739  DT.99944120  DT.95149695  DT.95270719 

    24/158 AceView cDNA sequences (see all 158):

    AI934453 AI948422 BX281510 CR600190 BI757693 BX446084 AA491233 BM711306 
    AI435262 BC032573 AI568664 BG059542 BX645222 BQ716206 AA338647 AI627328 
    BI554178 CD673053 AI566954 AA338646 BM679460 BX424479 AW339237 AI880344 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for APC2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:        -     -     -     -                             -     -     -     -     -     -     -                                             
    SP4:              -     -     -                                                                                                               
    SP5:                    -     -                                                                                                               


    ECgene alternative splicing isoforms for APC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCCTCCCGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See APC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APC2

    SOURCE GeneReport for Unigene cluster: Hs.446376

    UniProtKB/Swiss-Prot: APC2_HUMAN, O95996
    Tissue specificity: Widely expressed (at protein level). Specifically expressed in the CNS

        SABiosciences Expression via Pathway-Focused PCR Array including APC2: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for APC2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves APC21 adenomatosis polyposis coli 2 70.63(n)
    65.94(a)
      429363  NM_001171771.1  NP_001165242.1 
    lizard
    (Anolis carolinensis)
    Reptilia APC26
    --
    50(a)
    1 ↔ 1
    GL344458.1(12108-27259)
    zebrafish
    (Danio rerio)
    Actinopterygii apc21 adenomatosis polyposis coli 2 56.93(n)
    56.58(a)
      565771  XM_689041.5  XP_694133.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Apc26
    Apc6
    APC-like
    26(a)
    16(a)
    many ↔ many
    many ↔ many
    3R(19989690-19994041)
    3R(24658022-24670372)
    worm
    (Caenorhabditis elegans)
    Secernentea apr-16
    Adenomatous polyposis coli protein-related protein...
    15(a)
    possible ortholog
    I(8050038-8055469)


    ENSEMBL Gene Tree for APC2 (if available)
    TreeFam Gene Tree for APC2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APC2 gene
    APC2  ENSG000002588642  
    1 SIMAP similar gene for APC2 using alignment to 5 protein entries:     APC2_HUMAN (see all proteins):
    APC

    APC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/570 NCBI SNPs in APC2 are shown (see all 570    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131935851,2
    C,--1448171(+) ACCACG/ACGCCC 1 -- us2k12Minor allele frequency- A:0.05NA 122
    rs1504881411,2
    --1448172(+) CCACGC/TGCCCT 1 -- us2k10--------
    rs48079281,2
    C,F,A,H,--1448180(+) CCTACC/TCCATG 1 -- us2k122Minor allele frequency- T:0.29NS EA NA WA CSA 2348
    rs1383003271,2
    --1448243(+) TGGAAC/TGCCTC 1 -- us2k10--------
    rs1427720051,2
    --1448387(+) TTAAAA/CATACA 1 -- us2k10--------
    rs1829310551,2
    --1448521(+) GCCTGA/GGGGAC 1 -- us2k10--------
    rs2652991,2
    --1448594(+) aatccC/Gagcac 1 -- us2k1 tfbs32Minor allele frequency- G:0.00NA 4
    rs1998071061,2
    --1448677(+) CTACT-/AAAAAA 1 -- us2k10--------
    rs2652981,2
    C,F,--1448796(+) CGAGAT/ACGTGC 1 -- us2k1 tfbs36Minor allele frequency- A:0.17NA WA 12
    rs572772361,2
    C--1448843(+) AAAAA-/AAAAGA 1 -- us2k13Minor allele frequency- A:0.17NA CSA 6

    HapMap Linkage Disequilibrium report for APC2 (1446300 - 1473243 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for APC2
         5 CNVs: 10541 67431 7191 4066 5066

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APC2
    DNA2.0 Custom Variant and Variant Library Synthesis for APC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    APC2 for disorders           About GeneDecksing

    OMIM gene information: 612034    OMIM disorders: --

    9 diseases for APC2:    About MalaCards
    adenomatous polyposis coli    polyposis    familial adenomatous polyposis    basal cell carcinoma
    hepatitis b    endometrial cancer    colorectal cancer    hepatitis
    carcinoma

    3 Novoseek disease relationships for APC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 79.6 6 10646860 (2), 15018807 (1), 9823329 (1), 10021369 (1)
    tumors 18.3 7 10646860 (2), 11691822 (1), 15018807 (1), 9823329 (1)
    cancer 0 2 11691822 (1), 10021369 (1)

    Human Genome Epidemiology (HuGE) Navigator: APC2 (6 documents)

    Export disorders for APC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APC2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with APC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin. (PubMed id 9823329)1, 2, 3, 9 Nakagawa H.... Nakamura Y. (1998)
    2. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. (PubMed id 10021369)1, 2, 3, 9 van Es J.H.... Clevers H. (1999)
    3. Human APC2 localization and allelic imbalance. (PubMed id 11691822)1, 2, 9 Jarrett C.R.... Byers S.W. (2001)
    4. APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. (PubMed id 10646860)1, 2, 9 Nakagawa H.... Nakamura Y. (2000)
    5. EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue. (PubMed id 10644998)1, 2 Nakagawa H.... Nakamura Y. (2000)
    6. Regulation of Wnt signaling by the tumor suppressor ad enomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization. (PubMed id 22513088)1 Roberts D.M....Peifer M. (2012)
    7. Modulation of K11-linkage formation by variable loop residues within UbcH5A. (PubMed id 21396940)1 Bosanac I....Kirkpatrick D.S. (2011)
    8. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    9. Orf virus cell cycle regulator, PACR, competes with s ubunit 11 of the anaphase promoting complex for incorporation into the complex. (PubMed id 20826619)1 Mo M....Mercer A.A. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10297 HGNC: 24036 AceView: APC2 Ensembl:ENSG00000115266 euGenes: HUgn10297
    ECgene: APC2 Kegg: 10297 H-InvDB: APC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APC2 gene:
    Search GeneIP for patents involving APC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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