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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APC Gene

protein-coding GIFtS: 73
GCID: GC05P112101

adenomatous polyposis coli

(Previous name: adenomatosis polyposis coli )

Explore 178 diseases affiliated with
APC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenomatous Polyposis Coli¹ ²		GS² ⁵
DP2.5¹ ² ³		Adenomatosis Polyposis Coli¹
DP2¹ ²		Adenomatosis Polyposis Coli Tumor Suppressor²
DP3¹ ²		Adenomatous Polyposis Coli Protein²
PPP1R46¹ ²		Protein Phosphatase 1, Regulatory Subunit 46²
Deleted In Polyposis 2.5² ³		Protein APC³
BTPS2² ⁵		FPC⁵

External Ids:	HGNC: 583¹	Entrez Gene: 324²	Ensembl: ENSG00000134982⁷	OMIM: 611731⁵	UniProtKB: P25054³

Export aliases for APC gene to outside databases

Previous GC identifers: GC05P111687 GC05P112537 GC05P112074 GC05P112149 GC05P107222

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APC:

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also

involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects

in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually

progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation

cluster region (MCR) and result in a truncated protein product. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: APC_HUMAN, P25054

Function: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative

regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and

ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via

the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of

microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this

localization of MACF1 is critical for its function in microtubule stabilization

Gene Wiki entry for APC (Adenomatous polyposis coli)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APC gene promoter:
TBP STAT5B Spz1 NF-1 NF-1/L C/EBPbeta MyoD TFIID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): APC promoter sequence

Search SABiosciences Chromatin IP Primers for APC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21-q22 Ensembl cytogenetic band: 5q22.2 HGNC cytogenetic band: 5q21-q22

APC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APC gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P112101: view genomic region (about GC identifiers)

Start:	112,043,195 bp from pter	End:	112,181,936 bp from pter
Size:	138,742 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APC_HUMAN, P25054 (See protein sequence)

Recommended Name: Adenomatous polyposis coli protein

Size: 2843 amino acids; 311646 Da

Subunit: Forms homooligomers and heterooligomers with APC2. Interacts with DIAPH1 and DIAPH2 (By similarity). Interacts

with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with ARHGEF4 (via N-terminus).

Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends.

Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts

with SCRIB; may mediate APC targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via

N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain). Found in a complex composed of MACF1, APC, AXIN1,

CTNNB1 and GSK3B (By similarity). Interacts at the cell membrane with AMER1 and AMER2 (via ARM repeats)

Subcellular location: Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell

projection, ruffle membrane. Cytoplasm. Cell membrane. Note=Associated with the microtubule network at the growing

distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth

factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to

the cell membrane

Miscellaneous: APC mutations have led to some interesting observations. (1) the great majority of the mutations found

to date would result in truncation of the APC product. (2) almost all the mutations have occurred within the first

half of the coding sequence, and somatic mutations in colorectal tumors are further clustered in a particular region,

called MCR (mutation cluster region). (3) most identified point mutations in the APC gene are transitions from

cytosine to other nucleotides. (4) the location of germline mutations tends to correlate with the number of colorectal

polyps in FAP patients. Inactivation of both alleles of the APC gene seems to be required as an early event to develop

most adenomas and carcinomas in the colon and rectum as well as some of those in the stomach

6/17 PDB 3D structures from and Proteopedia for APC (see all 17):

1DEB (3D)

1EMU (3D)

1JPP (3D)

1M5I (3D)

1T08 (3D)

1TH1 (3D)

Secondary accessions: D3DT03 Q15162 Q15163 Q93042

Alternative splicing: 2 isoforms: P25054-1 P25054-2

Explore the universe of human proteins at neXtProt for APC: NX_P25054

Post-translational modifications:

Phosphorylated by GSK3B¹

Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by

ZRANB1/TRABID¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P25054

APC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000029.2 NP_001120982.1 NP_001120983.2

ENSEMBL proteins:

ENSP00000426541 ENSP00000423224 ENSP00000424265 ENSP00000257430 ENSP00000427089

ENSP00000423828 ENSP00000413133

Reactome Protein details: P25054
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): APC OriGene Custom Protein Services for APC
	GenScript Custom Purified and Recombinant Proteins Services for APC
	Novus Biologicals APC Protein Novus Biologicals APC Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for APC

Gene Ontology (GO): 5/23 cellular component terms (GO ID links to tree view) (see all 23): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000776	kinetochore	IDA	11283619
GO:0005634	nucleus	IDA	12072559
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	IDA	11283619
GO:0005829	cytosol	TAS	--

APC for ontologies About GeneDecksing

APC Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of APC
	R&D Systems Antibodies for APC
	Cell Signaling Technology (CST) Antibodies for APC
	OriGene Antibodies: APC OriGene Custom Antibody Services for APC
	GenScript Superior Antibodies for APC
	Novus Biologicals APC Antibodies
	Abcam antibodies for APC
	Uscn Antibodies for APC
	ThermoFisher Antibodies for APC

Assay Products for APC:

	EMD Millipore Kits and Assays for the Analysis of APC
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for APC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for APC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

APC for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR026818 Apc_fam

IPR011989 ARM-like

IPR009224 SAMP

IPR000225 Armadillo

IPR026836 APC

Graphical View of Domain Structure for InterPro Entry P25054

ProtoNet protein and cluster: P25054

1 Blocks protein family: IPB000225 Armadillo repeat

UniProtKB/Swiss-Prot: APC_HUMAN, P25054

Domain: The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the

growing microtubule plus ends (By similarity)

Similarity: Belongs to the adenomatous polyposis coli (APC) family

Similarity: Contains 7 ARM repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APC_HUMAN, P25054

Function: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative

regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and

ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via

the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of

microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this

localization of MACF1 is critical for its function in microtubule stabilization

Genatlas biochemistry entry for APC:

multidomain protein,binding beta-catenin and regulating free beta-catenin level,involved in cell adhesion and active

cell migration,mutated in adenomatous polyposis coli,colon and rectum carcinoma non polyposis,modulating the frequency

and classes of mutation leading to colon polyps

miRNA Products:		miRTarBase miRNAs that target APC: hsa-mir-210 (MIRT003183), hsa-mir-155 (MIRT001207)

		OriGene 3'-UTR Clone (see all 3): APC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APC
		8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate APC (see all 112):
		hsa-miR-579 hsa-miR-520e hsa-miR-300 hsa-miR-374a hsa-miR-519a hsa-miR-3916 hsa-miR-502-3p hsa-miR-3161

		SwitchGear 3'UTR luciferase reporter plasmid: APC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APC (see all 7) OriGene shRNA RFP: APC OriGene siRNA: APC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APC

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for APC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APC (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APC (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): APC (NM_001127510)
		Sino Biological Human cDNA Clone for APC
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for APC
		Search LifeMap BioReagents cell lines for APC

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APC

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008013	beta-catenin binding	IPI	7890674
GO:0008017	microtubule binding	IDA	16188939
GO:0019887	protein kinase regulator activity	IDA	11972058
GO:0019901	protein kinase binding	IPI	8638126

APC for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for APC:

Decreased POU5F1-GFP protein e

Decreased focal adhesion (FA)

Upregulation of Wnt/beta-caten

Animal Models:
     Mouse knock-outs for APC: Apc^tm1.1Tyj Apc^tm4Mmt Apc^tm1Cip Apc^tm1Rak Apc^tm1.1Tno Apc^tm1Mmt
                                               Apc^tm1Hsa Apc^tm1.1Ecrm Apc^tm2.1Rak
     15/27 MGI mutant phenotypes (inferred from 25 alleles) (MGI details for Apc) (see all 27):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail

APC for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt Signaling Pathway	0.33
Wnt Signaling Pathway and Pluripotency	0.55	Wnt signaling pathway	0.30
DNA damage response (only ATM dependent)	0.35	Wnt Signaling Pathway NetPath	0.22

Ubiquitinated Orc1 is degraded by the proteasome

	Degradation of beta-catenin by the destruction complex	0.72			Degradation of ubiquitinated -beta catenin by the proteasome	0.72
	Signaling by Wnt	0.72			Apoptosis	0.31

Apoptotic cleavage of cellular proteins

Apoptotic cleavage of cellular proteins

1.00

Apoptotic execution phase

0.73

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for APC

Selected targets of p53

1 R&D Systems Pathway for APC

Wnt Signaling Pathway

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for APC (see all 11)

	Factors Promoting Cardiogenesis in Vertebrates
	Molecular Mechanisms of Cancer
	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	Glioblastoma Multiforme

1 Cell Signaling Technology (CST) Pathway for APC

Wnt / Hedgehog / Notch

5/15 BioSystems Pathways for APC (see all 15)

	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway
	Irinotecan Pathway
	DNA damage response (only ATM dependent)
	Integrated Pancreatic Cancer Pathway

5/8 Reactome Pathways for APC (see all 8)

	Apoptotic execution phase
	Signaling by Wnt
	Degradation of beta-catenin by the destruction complex
	Apoptosis
	Degradation of ubiquitinated -beta catenin by the proteasome

5/6 Kegg Pathways (Kegg details for APC) (see all 6):

	Wnt signaling pathway
	Regulation of actin cytoskeleton
	Pathways in cancer
	Colorectal cancer
	Endometrial cancer

APC for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for APC

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/469 Interacting proteins for APC (P25054^{1, 2, 3} ENSP00000257430⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 469)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTNNB1	P35222¹^,²^,³, ENSP00000344456⁴	EBI-727707,EBI-491549 MINT-4508229 I2D: score=8 STRING: ENSP00000344456
DVL1	O14640²^,³, ENSP00000368169⁴	MINT-7897032 MINT-7897055 MINT-7897075 MINT-7897100 I2D: score=1 STRING: ENSP00000368169
DVL2	O14641²^,³, ENSP00000005340⁴	MINT-7890898 MINT-7897032 MINT-7897075 I2D: score=2 STRING: ENSP00000005340
PXN	P49023²^,³, ENSP00000228307⁴	MINT-7891130 MINT-7897100 I2D: score=2 STRING: ENSP00000228307
MAPRE1	Q15691¹^,³, ENSP00000364721⁴	EBI-727707,EBI-1004115 I2D: score=5 STRING: ENSP00000364721

About this table

Gene Ontology (GO): 5/63 biological process terms (GO ID links to tree view) (see all 63): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000281	cytokinesis after mitosis	IMP	17570218
GO:0001822	kidney development	IEA	--
GO:0001942	hair follicle development	IEA	--
GO:0006461	protein complex assembly	IDA	16188939
GO:0006915	apoptotic process	TAS	--

APC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

APC for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for APC
10/88 Novoseek chemical compound relationships for APC gene (see all 88) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
af/ap	80.5	4	10494086 (2), 11786778 (1), 15623495 (1)
crcs	74.3	10	11270422 (1), 17704924 (1), 11751382 (1), 14578138 (1) (see all 8)
sulindac	60.9	8	11535846 (3), 12663524 (2), 19755659 (1), 8707116 (1)
phip	60.7	17	19628463 (2), 9202752 (2), 11181456 (2), 9202738 (1) (see all 11)
glycogen	59.9	144	19339242 (9), 9003374 (5), 10233043 (5), 12829248 (5) (see all 55)
pphp	48.9	2	1621772 (1)
1-hydroxyanthraquinone	48	3	9433483 (2), 10204808 (1)
samp	47.7	3	10346819 (1), 10021369 (1), 10966653 (1)
5-aza-2'deoxycytidine	46.1	5	17065059 (1), 15087381 (1), 15225415 (1), 18058533 (1) (see all 5)
adenylate	38.1	15	2167212 (1), 10421220 (1), 1637317 (1), 8131796 (1) (see all 15)

Search CenterWatch for drugs/clinical trials and news about APC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APC gene (3 alternative transcripts):

NM_000038.5 NM_001127510.2 NM_001127511.2

Unigene Cluster for APC:

Adenomatous polyposis coli

Hs.158932 [show with all ESTs]

Unigene Representative Sequence: NM_001127510

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000509732 ENST00000505350 ENST00000507379 ENST00000508624 ENST00000257430(uc003kpz.4 uc003kpy.4 uc010jbz.3 uc010jca.3)

ENST00000508376 ENST00000512211 ENST00000506342 ENST00000502371 ENST00000504915

ENST00000505084 ENST00000514164 ENST00000457016(uc011cvt.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): APC Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APC
		8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate APC (see all 112):
		hsa-miR-579 hsa-miR-520e hsa-miR-300 hsa-miR-374a hsa-miR-519a hsa-miR-3916 hsa-miR-502-3p hsa-miR-3161

		SwitchGear 3'UTR luciferase reporter plasmid: APC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APC (see all 7) OriGene shRNA RFP: APC OriGene siRNA: APC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APC

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APC (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APC (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): APC (NM_001127510)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat APC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APC

Additional cDNA sequence:

AB210001.1 AF038181.1 AK289567.1 AK294544.1 AK309033.1 BC034955.1 BC056268.1 M73548.1

M74088.1 S56365.1 S67787.1 S67788.1 S67789.1

15 DOTS entries:

DT.99981468 DT.120809542 DT.40310104 DT.95121675 DT.99962531 DT.119384 DT.95374795 DT.120809704

DT.120809770 DT.452608 DT.449103 DT.91757887 DT.100721411 DT.432665 DT.91950191

24/445 AceView cDNA sequences (see all 445):

F04853 BF590515 D49676 BM723345 BU629028 F06864 BU618167 BF001542

R39002 AA829998 BG108327 AI566022 F02012 BM930344 F13412 F11337

T72565 F05691 AA344032 BX100792 BM977243 F12582 F01843 CA312933

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for APC About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17
SP1:																																					-
SP2:					-
SP3:

ECgene alternative splicing isoforms for APC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

APC expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Periportal Hepatocytes

Liver

Paraxial Mesoderm

Paraxial Mesoderm Cells

Mesoderm

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See APC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APC

SOURCE GeneReport for Unigene cluster: Hs.158932

UniProtKB/Swiss-Prot: APC_HUMAN, P25054

Tissue specificity: Expressed in a variety of tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including APC (see all 15):

Parkinson's Disease in human mouse rat

Oncogenes & Tumor Suppressor Genes in human mouse rat

Lung Cancer in human mouse rat

Multiple Sclerosis in human mouse rat

WNT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat APC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APC

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for APC gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	APC¹	adenomatous polyposis coli	80.69(n) 85.58(a)		415607 XM_001233410.2 XP_001233411.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	95(a) 83(a)	1 ↔ many 1 ↔ many	GL343193.1(6920773-6928072) GL343193.1(6928765-6980589)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8436²	Xenopus laevis adenomatous polyposis coli mRNA, complete more	78.78(n)		U64442.1
zebrafish (Danio rerio)	Actinopterygii	apc¹	adenomatosis polyposis coli	66.81(n) 70.85(a)		386762 NM_001143840.1 NP_001137312.1
fruit fly (Drosophila melanogaster)	Insecta	Apc³	frizzled-2 receptor signaling pathway microtubule more	54(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	apr-1⁶	Adenomatous polyposis coli protein-related protein...	18(a)	possible ortholog	I(8050038-8055469)

ENSEMBL Gene Tree for APC (if available)
TreeFam Gene Tree for APC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for APC gene

APC2² ENSG00000258864²

2 SIMAP similar genes for APC using alignment to 25 protein entries: APC_HUMAN (see all proteins):

APC variant protein APC2

APC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs459552^1,2	C,F,O,A,H,	non-pathogenic	112176756(-)	`TGAAGT/ACCTTG`	6	/D /V	mis¹ ese³		42		MN NA NS EA WA CSA EU	8811
rs137854567^1,2	C,F,	pathogenic	107334073(+)	`AGATAC/TGCGCT`	6	R C	mis¹		2		NA EU	5871
rs137854580^1,2	C	pathogenic	107341994(+)	`TAAGAC/G/TGATAT`	9	R G *	mis¹ stg¹		1		EU	1323
rs137854575^1,2	C,F,	pathogenic	107353190(+)	`ACTTAA/C/TAATTT`	9	* Y	stg¹ syn¹		2		NA EU	5701
rs1801155^1,2	C,F	pathogenic	112175211(+)	`AGAAAT/AAAAAG`	6	/K /I	mis¹		3		EU NA	5971
rs121913224^1,2	C	pathogenic	112175218(+)	`AAAGA-/AAAGA TTGGA`	6	DW EKI	fra¹		0	--	--	--	--
rs1801166^1,2	C,F,	pathogenic	112175240(+)	`CAGCTG/CAAGAT`	6	/Q /E	mis¹		3		NA EU	5859
rs121913327^1,2	C	other	107354397(+)	`GACTGC/TAGGGT`	6	Q *	stg¹		0	--	--	--	--
rs464338^1,2	C,F,H,	other	112064826(+)	`AAATTC/GTCTTA`	1	--	int¹		14		NS EA NA WA CSA	551
rs469336^1,2	C,F,H,	other	112066524(+)	`GTGTCC/GAACCT`	1	--	int¹		13		NS EA NA WA CSA	550
rs2019720^1,2	C,F,O,A,H,	other	112074269(+)	`AACAGA/GTACCA`	4	--	int¹		24		NA EA NS	1752
rs2020383^1,2	C,F,O,A,H,	other	112074356(+)	`TAGGCC/TGAAAA`	4	--	int¹		20		NS EA NA WA CSA	1011
rs4705608^1,2	C,F,A,H,	other	112077447(+)	`AAAACA/TCTGTG`	4	--	int¹		9		NS EA NA	652
rs4705609^1,2	C,F,A,H,	other	112077770(+)	`ATGCTG/ACTATG`	4	--	int¹		11		NA WA CSA EA	374
rs6594646^1,2	C,F,A,H,	other	112081924(+)	`ACTTTA/GAAATA`	4	--	int¹		18		NS EA NA WA	2342
rs28373740^1,2	C,F,	other	112085611(+)	`TTGTTG/TTTTTT`	4	--	int¹ trp³		6		NA EA	248
rs12518091^1,2	C,F,H,	other	112086165(+)	`TTTTCT/ATGGCT`	4	--	int¹ trp³		11		NS EA NA WA	778
rs4705617^1,2	C,F,A,H,	other	112088507(+)	`ATAAAA/GTTAGA`	4	--	int¹		17		NS EA NA WA CSA	1456
rs2439591^1,2	C,F,O,A,H,	other	112089480(+)	`TTATTC/TTGTGT`	4	--	int¹		31		NA NS EA WA CSA	2855
rs4099181^1,2	C,F,A,H,	other	112091704(-)	`AGAGGC/GAGAAA`	3	--	int¹ trp³		15		NA NS EA CSA WA	913
rs4705486^1,2	C,F,A,H,	other	112092402(+)	`TACCCT/GTAGAT`	3	--	int¹		27		NS EA NA WA	2900
rs76641316^1,2	C,	other	112093425(+)	`AAGTAC/GGTCTC`	3	--	int¹		0	--	--	--	--
rs369952^1,2	C,F,H,	other	112093955(+)	`TGTGTG/AGTGTA`	3	--	int¹		14		NS EA NA WA CSA	788
rs76013957^1,2	C	other	112094300(+)	`ACAGGA/CATGAG`	3	--	int¹		0	--	--	--	--
rs74394833^1,2	C	other	112094302(+)	`AGGCAG/TGAGCC`	3	--	int¹		0	--	--	--	--
rs74578553^1,2	C	other	112094543(+)	`GATCCA/CCCCGC`	3	--	int¹		0	--	--	--	--
rs2546116^1,2	C,F,A,H,	other	112095332(+)	`CAGGCG/ATGAGC`	3	--	int¹		3		NA	6
rs77819922^1,2	C	other	112095333(+)	`AGGCGG/TGAGCC`	3	--	int¹		0	--	--	--	--
rs79703980^1,2	C	other	112095499(+)	`GTATTA/TAAAAG`	3	--	int¹		0	--	--	--	--
rs77280974^1,2	C	other	112095504(+)	`TAAAAC/GCTGCC`	3	--	int¹		0	--	--	--	--
rs4705624^1,2	C,F,A,H,	other	112095775(+)	`TAAGCT/AGAGAT`	3	--	int¹		14		EA NS NA WA	800
rs11241184^1,2	C,F,A,H,	other	112097757(+)	`AAAAGG/ACAATC`	3	--	int¹		6		NA EA	248
rs380589^1,2	C,H,	other	112098911(-)	`CCACAT/CTTCCT`	3	--	int¹		9		NA WA CSA EA	368
rs9647582^1,2	C,A,H,	other	112098938(+)	`TCAACT/AATTTT`	3	--	int¹		4		NA WA EA	360
rs9647583^1,2	C,F,A,H,	other	112099028(+)	`ATGCAG/AACTTG`	3	--	int¹		2		NA EA	240
rs78880731^1,2	C	other	112099060(+)	`GCAGGG/TTTTTT`	3	--	int¹		0	--	--	--	--
rs76994479^1,2	C	other	112099069(+)	`TTTTTC/TCTGTG`	3	--	int¹		0	--	--	--	--
rs7703438^1,2	C,F,A,H,	other	112099496(+)	`CCTGAG/AAACTT`	3	--	int¹		7		EA NS CSA WA NA	652
rs75075213^1,2	C	other	112099668(+)	`GGTGGC/GTCACG`	3	--	int¹		0	--	--	--	--
rs7723423^1,2	C,A,	other	112099690(+)	`AGCACC/TTTGGG`	3	--	int¹		1		CSA	2
rs79492842^1,2	C	other	112099793(+)	`AAAAAA/TTTAGC`	3	--	int¹		0	--	--	--	--
rs6867243^1,2	C,F,A,H,	other	112100027(+)	`CACTTA/GGGAAA`	3	--	int¹		12		NA WA CSA EA	511
rs75064858^1,2	C,	other	112100295(+)	`GTCATA/GCAGAT`	3	--	int¹		1		EA	120
rs76596358^1,2	C,	other	112100496(+)	`GAATTA/GGAATC`	3	--	int¹		0	--	--	--	--
rs2464807^1,2	C,H,	other	112100595(-)	`TGAATG/TTGAAT`	3	--	int¹		11		NA WA CSA	254
rs75950054^1,2	C,F,	other	112100982(+)	`TGTTTT/GTTTAA`	3	--	int¹		1		EA	120
rs12659119^1,2	C,F,H,	other	112101457(+)	`AAAGGT/GATTAC`	3	--	int¹ trp³		8		NA CSA WA EA	367
rs2464806^1,2	C,A,H,	other	112101496(-)	`CACTAT/CTTCTT`	3	--	int¹		13		NA WA CSA EA	375
rs78519130^1,2	C,	other	112101640(+)	`ATGTTC/G/TGTGCA`	3	--	int¹		0	--	--	--	--
rs78418904^1,2	C,F,	other	112101673(+)	`AACACA/GTAAGT`	3	--	int¹		2		WA EA	238
rs2304793^1,2	C,F,H,	other	112101970(-)	`AAGACA/GTGATT`	3	--	int¹		29		EA NS NA MN WA	4152
rs78035234^1,2	C	other	112104061(+)	`TTACCC/AAAAAA`	3	--	int¹		1		NA	2
rs35414976^1,2	C,F,	other	112104297(+)	`TTGCAG/ATCAGG`	3	--	int¹		5		NA EA	246
rs77010277^1,2	C,F,	other	112105208(+)	`GGAACT/GTCGTC`	3	--	int¹		2		WA EA	238
rs62364016^1,2	C,	other	112105218(+)	`CAAATG/TTTTTA`	3	--	int¹		1		NA	2
rs75372333^1,2	C,	other	112105534(+)	`AAATAA/GGGATA`	3	--	int¹		0	--	--	--	--
rs11241185^1,2	C,F,A,H,	other	112107058(+)	`AATTTG/ATACCA`	3	--	int¹		17		NS EA NA	2224
rs6876867^1,2	C	other	112107084(+)	`TGCTAA/C/GAAGAC`	3	--	int¹		0	--	--	--	--
rs78426873^1,2		other	112108013(+)	`AGTCAA/CAAGGT`	3	--	int¹		0	--	--	--	--
rs78349576^1,2	C	other	112108019(+)	`AAGGTA/CAACTA`	3	--	int¹		0	--	--	--	--
rs78112535^1,2	C	other	112108164(+)	`TCAACA/CCTGCC`	3	--	int¹		0	--	--	--	--
rs2707763^1,2	C,F,A,H,	other	112108865(+)	`AAGCTT/CATTTC`	3	--	int¹		14		NA NS EA CSA WA	904
rs75582423^1,2	C	other	112108962(+)	`CATATA/TTCCTA`	3	--	int¹		0	--	--	--	--
rs1816769^1,2	C,F,A,H,	other	112109779(+)	`TATAGC/GTATAA`	3	--	int¹		16		NS EA NA CSA WA	920
rs78800922^1,2	C,	other	112109812(+)	`TATAAA/C/TAACAA`	3	--	int¹		0	--	--	--	--
rs79801520^1,2	C,	other	112110003(+)	`GTAACA/GTGATG`	3	--	int¹		0	--	--	--	--
rs74639338^1,2	C,F,	other	112110660(+)	`GAAAAG/AAGATA`	3	--	int¹		2		WA EA	238
rs392179^1,2	C,A,H,	other	112111070(+)	`CCTTTA/GGTGAA`	3	--	int¹		11		NA WA CSA EA	373
rs78919815^1,2	C,	other	112111310(+)	`TTTTTA/TAAAAA`	3	--	int¹		0	--	--	--	--
rs74471574^1,2	C	other	112111463(+)	`TATTTG/TAAACT`	3	--	int¹		0	--	--	--	--
rs458906^1,2	C,F,O,A,	other	112111866(+)	`CAATAC/GCTATA`	3	--	int¹		10		NA EA	392
rs80067367^1,2	C,	other	112112113(+)	`CACCGA/GTTTAT`	3	--	int¹		0	--	--	--	--
rs76382224^1,2	C	other	112112747(+)	`GGCTGC/GTTTAA`	3	--	int¹		0	--	--	--	--
rs80287587^1,2	C	other	112112751(+)	`GCTTTA/TAAATT`	3	--	int¹		0	--	--	--	--
rs7707339^1,2	C,F,	other	112112855(+)	`TCTTAG/AATTGT`	3	--	int¹		3		WA NA EA	358
rs79528641^1,2	C	other	112112911(+)	`GTTTTG/TGTAAA`	3	--	int¹		0	--	--	--	--
rs77941389^1,2	C,F,	other	112112951(+)	`TTACGT/CGTGCA`	3	--	int¹		1		WA	118
rs76977570^1,2	C	other	112113202(+)	`TAATGA/CAAAAG`	3	--	int¹		0	--	--	--	--
rs467033^1,2	C,F,O,A,H,	other	112113527(+)	`TCAAGA/TCATCT`	3	--	int¹		20		NS EA NA WA	2336
rs396321^1,2	C,F,A,H,	other	112113735(+)	`CCTTCC/TGCTTA`	3	--	int¹		22		NA NS EA CSA WA	2361
rs401908^1,2	C,F,A,	other	112113760(+)	`TTTCCC/TATTCA`	3	--	int¹		12		WA NA CSA EA	375
rs414098^1,2	C,F,O,A,H,	other	112113772(+)	`TACACA/GTCAGT`	3	--	int¹		10		NS EA NA	660
rs75246712^1,2	C	other	112114067(+)	`GGCTGC/GGTCAG`	3	--	int¹		0	--	--	--	--
rs78706182^1,2	C	other	112114180(+)	`AAAAAA/GAAAAT`	3	--	int¹		0	--	--	--	--
rs75882432^1,2	C	other	112114521(+)	`AGGTGG/TGAGCC`	3	--	int¹		0	--	--	--	--
rs78370128^1,2	C,	other	112115377(+)	`TTTTTG/TCAGAG`	3	--	int¹		1		NA	2
rs35130225^1,2	C,F,	other	112116069(+)	`AGTATA/GAGCTT`	3	--	int¹		13		NA WA CSA EA	378
rs2707765^1,2	C,F,A,H,	other	112122532(-)	`GTCCAG/CAAAAC`	4	--	int¹		10		NS EA NA	666
rs75111475^1,2	C,	other	112128249(+)	`CTTGTC/G/TTGTGG`	3	--	int¹		0	--	--	--	--
rs79627325^1,2	C,F,	other	112128314(+)	`CACCAT/CTGAAA`	3	--	int¹		1		EA	120
rs75248404^1,2	C,F,	other	112128673(+)	`AAAGCA/GGGTAA`	3	--	int¹		2		WA EA	238
rs75075708^1,2		other	112129194(+)	`GACTTA/TCATGG`	3	--	int¹		0	--	--	--	--
rs79184658^1,2	C,	other	112129195(+)	`ACTTAA/CATGGA`	3	--	int¹		0	--	--	--	--
rs79631489^1,2	C	other	112129196(+)	`CTTACA/TTGGAA`	3	--	int¹		0	--	--	--	--
rs66964065^1,2	C,	other	112129754(+)	`AAAAAG/AGTAGG`	3	--	int¹		1		WA	2
rs74725869^1,2	C	other	112130056(+)	`ACAGGC/GGTGAG`	3	--	int¹		0	--	--	--	--
rs1734243^1,2	C,F,A,	other	112130086(+)	`TTAAAA/CCTTTT`	3	--	int¹		10		NA WA CSA EA	371
rs2431514^1,2	C,F,A,	other	112131288(+)	`CCCCTG/ATCACT`	3	--	int¹		9		NA CSA EA	253
rs2464803^1,2	C,F,A,H,	other	112131787(-)	`GTTCAT/CTTGGG`	3	--	int¹		27		NS EA NA WA	3126
rs78704421^1,2	C	other	112132534(+)	`CCCCCA/TTCTTT`	3	--	int¹		0	--	--	--	--
rs76293460^1,2	C,	other	112132707(+)	`ATTTAA/TTAATA`	3	--	int¹		0	--	--	--	--
rs76804542^1,2	C,	other	112132948(+)	`AGAACA/GAAACC`	3	--	int¹		3		CSA WA EA	240
rs75948898^1,2		other	112133846(+)	`TTTTTA/CATAAT`	3	--	int¹		0	--	--	--	--
rs76500274^1,2	C,	other	112134643(+)	`GGCTCA/CTGCCT`	3	--	int¹		0	--	--	--	--
rs1644240^1,2	C,F,A,	other	112134837(-)	`atggcG/Acaatc`	3	--	int¹		3		WA CSA EA	124
rs517947^1,2	C,H,	other	112135067(+)	`AGGAAC/TGTAGG`	3	--	int¹		12		NA WA CSA EA	374
rs78193332^1,2	C,F,	other	112135499(+)	`ATTCGT/ATGACA`	3	--	int¹		2		WA EA	238
rs77553156^1,2	C,	other	112136846(+)	`ATACAC/GAGTTC`	3	--	int¹		0	--	--	--	--
rs77862570^1,2	C,F,	other	112138189(+)	`ACATAG/AGAATA`	3	--	int¹		2		WA EA	238
rs77744608^1,2	C,F,	other	112138542(+)	`CGTGTA/GAAAAG`	3	--	int¹		3		WA NA EA	358
rs529076^1,2	C,F,	other	112138734(+)	`AGATGA/GTCAAC`	3	--	int¹		11		NA WA CSA EA	373
rs2952615^1,2	C,F,H,	other	112138888(-)	`GAAAGG/CCTGTT`	3	--	int¹		14		NS EA NA WA CSA	789
rs75115654^1,2		other	112139634(+)	`CTCCCA/CTATAT`	3	--	int¹		0	--	--	--	--
rs2545158^1,2	C,F,O,A,H,	other	112139745(+)	`TGAGTA/GTGTCC`	3	--	int¹		11		EA NA WA	558
rs17134945^1,2	C,F,H,	other	112140022(+)	`AACTAA/GTATGT`	3	--	int¹		19		NA NS EA CSA WA	2242
rs75020201^1,2	C	other	112140356(+)	`AGGCGG/TGAGCC`	3	--	int¹		0	--	--	--	--
rs79822557^1,2	C,	other	112140570(+)	`GCTACG/TTGGGA`	3	--	int¹		0	--	--	--	--
rs78473324^1,2	C	other	112140705(+)	`AAAAAA/TAAAAA`	3	--	int¹		0	--	--	--	--
rs79381877^1,2	C,F,	other	112140749(+)	`TATACA/GTATGT`	3	--	int¹		1		EA	120
rs79627126^1,2	C,	other	112140941(+)	`GAAAAT/CAGAAG`	3	--	int¹		4		CSA WA NA EA	360
rs75165325^1,2	C,F,	other	112141153(+)	`AGTATG/ATTTGT`	3	--	int¹		2		WA EA	238
rs79415340^1,2	C,	other	112141410(+)	`TTGCTA/CAAAAG`	3	--	int¹		0	--	--	--	--
rs77026538^1,2	C	other	112141747(+)	`CCTTCC/TCCTAC`	3	--	int¹		0	--	--	--	--
rs78088437^1,2	C	other	112141751(+)	`CTCCTA/CCCACA`	3	--	int¹		0	--	--	--	--
rs75784685^1,2	C,	other	112141754(+)	`CTACCA/CCAGCC`	3	--	int¹		0	--	--	--	--
rs79147157^1,2	C	other	112142361(+)	`CCTCTC/GCCTCC`	3	--	int¹		0	--	--	--	--
rs76427052^1,2	C	other	112142364(+)	`CTGCCC/TCCCAG`	3	--	int¹		0	--	--	--	--
rs79737175^1,2	C	other	112142373(+)	`AGGCTA/CAAGCC`	3	--	int¹		0	--	--	--	--
rs1914^1,2	C,F,A,H,	other	112144444(-)	`CAAAAA/TCTAGA`	3	--	int¹		9		NS EA NA	664
rs2546106^1,2	C,F,A,H,	other	112145261(+)	`CATTGC/ACATGA`	3	--	int¹		28		NS EA NA CSA	3014
rs454886^1,2	C,F,O,H,	other	112146117(-)	`AAAACT/CGTGGC`	3	--	int¹		19		NS EA NA	2354
rs390092^1,2	C,F,A,H,	other	112146197(-)	`CTATAA/CCTGCC`	3	--	int¹		14		EA NS NA WA	808
rs75495165^1,2	C,	other	112146264(+)	`AGTTAC/TGTAAG`	3	--	int¹		1		EA	120
rs79512327^1,2	C	other	112149351(+)	`GGCTCC/GTGCCT`	3	--	int¹		0	--	--	--	--
rs2545169^1,2	C,F,A,H,	other	112149757(-)	`TCTTAG/AGCTTA`	3	--	int¹		25		NS EA WA NA CSA	2766
rs74796412^1,2	C,F,	other	112149969(+)	`TTTATC/TTGCAA`	3	--	int¹		1		EA	120
rs76128575^1,2	C	other	112151834(+)	`ATTGGG/TGGGGA`	3	--	int¹		0	--	--	--	--
rs17134960^1,2	C,F,H,	other	112152206(+)	`TTACTT/GTAAGC`	3	--	int¹		12		NA NS EA CSA WA	924
rs74858737^1,2	C	other	112152224(+)	`GGTGGC/GTCACA`	3	--	int¹		0	--	--	--	--
rs76238841^1,2	C	other	112152227(+)	`GGCTCA/CCACCT`	3	--	int¹		0	--	--	--	--
rs79171167^1,2	C	other	112152233(+)	`CACCTG/TTAATC`	3	--	int¹		0	--	--	--	--
rs78924999^1,2	C,F,	other	112152830(+)	`CCAAAG/ATGCTG`	3	--	int¹		1		EA	120
rs17164132^1,2	C,F,H,	other	112152920(+)	`CTAAAC/TGATGT`	3	--	int¹		21		NA NS EA WA CSA	2266
rs2545165^1,2	C,F,O,H,	other	112153119(-)	`CATATA/GAGGTC`	3	--	int¹		16		NA NS EA WA CSA	926
rs75075800^1,2	C	other	112153172(+)	`CTCTCA/CAAAAT`	3	--	int¹		0	--	--	--	--
rs392907^1,2	C,F,A,H,	other	112153495(+)	`CTCAGG/AAAACT`	3	--	int¹		15		NS EA NA WA CSA	779
rs2545164^1,2	C,F,O,A,H,	other	112153665(-)	`CTTTAA/GATGCG`	3	--	int¹		15		NA WA CSA EA	514
rs78751466^1,2	C,	other	112153757(+)	`CCCACT/CAGATT`	3	--	int¹		3		CSA WA EA	240
rs77378981^1,2	C,F,	other	112153861(+)	`GAGAAC/ACATTG`	3	--	int¹		1		EA	120
rs76977827^1,2	C	other	112154154(+)	`TAATAA/TTATCA`	3	--	int¹		0	--	--	--	--
rs78373307^1,2	C	other	112154155(+)	`AATATC/TATCAT`	3	--	int¹		0	--	--	--	--
rs72663315^1,2	C,	other	112154531(+)	`TTTTTT/GTTTTT`	3	--	int¹		1		CSA	1
rs77766408^1,2	C	other	112154541(+)	`TTTTTG/TGGCGG`	3	--	int¹		0	--	--	--	--
rs78602351^1,2	C	other	112154544(+)	`TTTGGC/GGGGGG`	3	--	int¹		0	--	--	--	--
rs77907679^1,2	C,	other	112155003(+)	`GCAGGA/GAGCTC`	6	E G	mis¹		0	--	--	--	--
rs74736032^1,2	C	other	112155410(+)	`GTGTCA/CAAACC`	3	--	int¹		0	--	--	--	--
rs2545163^1,2	C,F,A,H,	other	112155504(-)	`CTTCAC/GTAGGT`	3	--	int¹		16		NS EA NA WA CSA	787
rs501250^1,2	C,F,H,	other	112155793(+)	`CTATGC/GGGATA`	3	--	int¹		25		NS EA WA NA CSA	2765
rs75710383^1,2	C	other	112156080(+)	`GGTGGG/TTCATG`	3	--	int¹		0	--	--	--	--
rs79851383^1,2	C	other	112156099(+)	`GGCAGC/GACTTT`	3	--	int¹		0	--	--	--	--
rs6885768^1,2	C,F,	other	112156863(+)	`ACCTAG/CCACCA`	3	--	int¹		7		WA NA CSA EA	365
rs2545162^1,2	C,F,O,A,H,	other	112158431(-)	`TTAAGT/CGTATG`	3	--	int¹		29		NA NS EA WA CSA	2907
rs77551834^1,2	C,F,	other	112158480(+)	`CGTTTA/TTGTTA`	3	--	int¹		1		EA	120
rs78475274^1,2	C	other	112158494(+)	`TATGTC/TCCAGC`	3	--	int¹		0	--	--	--	--
rs79083929^1,2	C,	other	112159360(+)	`TTAGAA/GGTTTT`	3	--	int¹		4		CSA WA NA EA	360
rs2545160^1,2	C,H,	other	112159385(-)	`ACATAC/TATCAT`	3	--	int¹		17		NS EA NA WA CSA	781
rs2546107^1,2	C,F,O,	other	112159470(+)	`CTTTCG/AGGGAA`	3	--	int¹		8		NA EA	388
rs75491644^1,2	C,F,	other	112159545(+)	`TCGTCA/CAACTG`	3	--	int¹		3		WA NA EA	358
rs2545159^1,2	C,F,O,A,	other	112159562(-)	`TACAGC/TGCCAG`	3	--	int¹		15		EA NA WA CSA	585
rs75821202^1,2	C	other	112160462(+)	`GGCCAA/TGTCTT`	3	--	int¹		0	--	--	--	--
rs77948403^1,2	C	other	112160463(+)	`GCCAAC/GTCTTA`	3	--	int¹		0	--	--	--	--
rs79032423^1,2	C	other	112160936(+)	`CTTCAC/TCCCCA`	3	--	int¹		0	--	--	--	--
rs2546108^1,2	C,F,A,H,	other	112161469(+)	`TTTTTC/ATTATG`	3	--	int¹ trp³		31		NS EA NA WA	3264
rs73789211^1,2	C	other	112162299(+)	`AAAAAC/AAAAAC`	3	--	int¹		1		WA	2
rs2546110^1,2	C,F,O,A,H,	other	112162413(+)	`TGACAA/GTAAAG`	3	--	int¹		20		NA NS EA	2360
rs2229992^1,2	C,F,O,A,H,	other	112162854(+)	`ATGTAC/TGGGCT`	6	Y	syn¹		31		MN NS EA NA WA EU	8917
rs75941845^1,2		other	112163242(+)	`AGTTTA/TACTGT`	3	--	int¹		0	--	--	--	--
rs74725935^1,2	C	other	112163838(+)	`AGCAAC/TCCTCC`	3	--	int¹		0	--	--	--	--
rs187075^1,2	C,F,	other	112164238(+)	`TCAAGT/CTCCTG`	3	--	int¹		12		NA WA CSA EA	375
rs351772^1,2	C,F,A,	other	112164862(+)	`ATGGGG/ATCTCT`	3	--	int¹		10		MN NA CSA WA EA	554
rs80164775^1,2	C	other	112165114(+)	`AGGCGA/CAAGCC`	3	--	int¹		0	--	--	--	--
rs76839155^1,2	C,F,	other	112165375(+)	`ACCCTC/TCCCCT`	3	--	int¹		1		EA	120
rs79636900^1,2	C	other	112165722(+)	`GCTAGC/TCCTCC`	3	--	int¹		0	--	--	--	--
rs75190104^1,2	C,F,	other	112165989(+)	`TGGCCG/AATAAG`	3	--	int¹		2		WA EA	238
rs74531593^1,2	C	other	112166046(+)	`TAAAAA/CTACAA`	3	--	int¹		0	--	--	--	--
rs67111599^1,2	C,	other	112166047(+)	`AAAACA/TACAAT`	3	--	int¹		0	--	--	--	--
rs78798527^1,2		other	112166213(+)	`CATACA/CCCTGC`	3	--	int¹		0	--	--	--	--
rs75209153^1,2	C	other	112166479(+)	`TTGGGA/GGTAGA`	3	--	int¹		0	--	--	--	--
rs80072260^1,2	C	other	112166569(+)	`TTTATG/TGGTGT`	3	--	int¹		0	--	--	--	--
rs76302894^1,2	C	other	112166825(+)	`TTTTTG/TAGATG`	3	--	int¹		0	--	--	--	--
rs548710^1,2	C,F,	other	112167587(+)	`ACCTTT/CGTGTA`	3	--	int¹		16		EA NA MN	982
rs569940^1,2	C,F,	other	112167821(+)	`ATAACT/CTCTAA`	3	--	int¹		10		NA WA CSA EA	371
rs11960216^1,2	C,H,	other	112167921(+)	`CTTTTG/ATATTT`	3	--	int¹		4		CSA WA NA EA	360
rs2909958^1,2	C,F,O,A,H,	other	112167941(+)	`CAACTG/CTCAAC`	3	--	int¹		93		NS EA PA EU CA WA NA CSA	4743
rs2909786^1,2	C,F,A,H,	other	112168065(+)	`TCTTGG/ATTGAT`	3	--	int¹		99		EA NS PA EU CA WA MN NA CSA	6241
rs2909787^1,2	C,F,O,A,H,	other	112168130(+)	`CTTATC/GTGACA`	3	--	int¹		100		EA NS PA EU CA WA MN NA CSA	6641
rs80072625^1,2	C	other	112168379(+)	`CTACTC/TCCCCT`	3	--	int¹		0	--	--	--	--
rs2546111^1,2	C,F,A,H,	other	112169525(+)	`ACCACA/TTGTAT`	3	--	int¹		11		NA WA CSA EA	373
rs918397^1,2	C,F,	other	112169624(-)	`ATACAT/CAGATA`	3	--	int¹		6		WA CSA NA EA	364
rs76577654^1,2	C,F,	other	112169890(+)	`GTCAGC/GCTTCC`	3	--	int¹		2		WA EA	238
rs396971^1,2	C	other	112169958(-)	`CTTTTA/TAAAAA`	3	--	int¹		0	--	--	--	--
rs77807720^1,2	C	other	112170071(+)	`GTAGCG/TGGGAT`	3	--	int¹		0	--	--	--	--
rs74797473^1,2	C	other	112170074(+)	`GCTGGA/GATTAC`	3	--	int¹		0	--	--	--	--
rs77304999^1,2	C	other	112170082(+)	`TACAGC/GCACCT`	3	--	int¹		0	--	--	--	--
rs78897872^1,2	C	other	112170084(+)	`CAGGCA/CCCTGC`	3	--	int¹		0	--	--	--	--
rs79826411^1,2	C	other	112170221(+)	`AGGCAG/TGAGCC`	3	--	int¹		0	--	--	--	--
rs77504726^1,2	C,F,	other	112170285(+)	`TTCTTT/ATTTCA`	3	--	int¹		1		EA	120
rs458967^1,2	C,F,A,	other	112170358(-)	`CACAAT/CTGATG`	3	--	int¹		11		WA NA CSA EA	375
rs76836190^1,2	C	other	112170436(+)	`ATATTG/TTGTTC`	3	--	int¹		0	--	--	--	--
rs75117039^1,2	C,	other	112170816(+)	`GTGGGA/GTATTA`	6	I V	mis¹		0	--	--	--	--
rs62626346^1,2	C,F,	other	112170870(-)	`ACTCTA/GTATAT`	3	--	int¹		3		EU EA	1075
rs6899169^1,2	C,F,	other	112171097(+)	`AGCCCA/GTAGGT`	3	--	int¹		2		WA EA	238
rs74735048^1,2	C	other	112171250(+)	`GATGTC/TTTAGT`	3	--	int¹		0	--	--	--	--
rs79726949^1,2	C	other	112171254(+)	`TCTTAG/TTATCC`	3	--	int¹		0	--	--	--	--
rs75350935^1,2	C	other	112171285(+)	`TTTTTG/TTTGAG`	3	--	int¹		1		NA	2
rs76537265^1,2	C	other	112171691(+)	`ATCAAA/CAAAAA`	3	--	int¹		0	--	--	--	--
rs79031187^1,2	C	other	112171722(+)	`TTTTTC/TTTTTT`	3	--	int¹		0	--	--	--	--
rs411356^1,2	C,F,A,H,	other	112172219(-)	`ATATTT/CAGCTT`	3	--	int¹		22		NS EA NA WA CSA	2343
rs75824617^1,2	C	other	112172679(+)	`AGGCAG/TGAGCC`	3	--	int¹		0	--	--	--	--
rs1966477^1,2	C,F,O,A,	other	112172786(-)	`ATAAGA/CTCTTA`	3	--	int¹		11		NA WA CSA EA	372
rs1966476^1,2	C,F,O,A,H,	other	112172930(-)	`AAACTA/GTATCA`	3	--	int¹		8		NA WA EA	368
rs74571271^1,2	C	other	112173105(+)	`TGAAAA/TTAGAA`	3	--	int¹		0	--	--	--	--
rs75266200^1,2	C	other	112173106(+)	`GAAATA/TAGAAC`	3	--	int¹		0	--	--	--	--
rs78611569^1,2	C,	other	112173111(+)	`TAGAAA/CAAAAG`	3	--	int¹		0	--	--	--	--
rs76565799^1,2	C,	other	112173112(+)	`AGAACA/GAAAGG`	3	--	int¹		0	--	--	--	--
rs80188155^1,2	C	other	112173676(+)	`AGTCTC/TTATGG`	6	L	syn¹		0	--	--	--	--
rs79853077^1,2	C	other	112173695(+)	`TTTTTG/TACACC`	6	D Y	mis¹		0	--	--	--	--
rs79122263^1,2	C	other	112175021(+)	`AGCCTA/CAAAAG`	6	K Q	mis¹		0	--	--	--	--
rs74535574^1,2	C	other	112175576(+)	`CTGGAA/C/TAAACC`	9	K Q *	mis¹ stg¹		0	--	--	--	--
rs41115^1,2	C,F,O,A,H,	other	112175770(-)	`CTTTCC/TGTGGC`	6	T	syn¹ ese³		39		MN EA NA NS WA CSA EU	8740
rs42427^1,2	C,F,A,H,	other	112176325(+)	`GGAGGA/GGCACA`	6	G	syn¹ ese³ trp³		34		MN NA NS EA WA CSA EU	8768
rs866006^1,2	C,F,O,A,H,	other	112176559(-)	`GAAGAC/AGACGC`	6	/S	syn¹ ese³		37		MN NA NS EA WA CSA EU	8662
rs465899^1,2	C,F,A,H,	other	112177171(-)	`CAAACT/CGGAGT`	6	/P	syn¹ ese³		118		EA NA MN NS PA EU CA WA CSA	12756
rs75207119^1,2	C	other	112178340(+)	`ATCATA/C/TCCCTA`	9	Y S F	mis¹		0	--	--	--	--
rs78556145^1,2	C	other	112178341(+)	`TCATCA/CCCTAG`	6	S	syn¹		0	--	--	--	--
rs76933416^1,2	C	other	112179425(+)	`GTGTTC/TCCATG`	6	P S	mis¹		0	--	--	--	--
rs1804197^1,2	C,F,A,H,	other	112179909(+)	`AAAGAC/ATGAAA`	3	--	ut3¹		6		MN NA WA EA	564
rs79414727^1,2	C	other	112179958(+)	`TGTTCG/TGGAAG`	3	--	ut3¹		0	--	--	--	--
rs79379053^1,2	C	other	112180228(+)	`TTATGA/CAAAAA`	3	--	ut3¹		0	--	--	--	--
rs12189^1,2	C,F,A,H,	other	112180257(+)	`TGAGTC/TCATCT`	3	--	ut3¹ ese³		19		MN NS EA NA WA	2544
rs74503138^1,2	C	other	112180290(+)	`CTGTGA/GAATTC`	3	--	ut3¹		0	--	--	--	--
rs41116^1,2	C,F,A,H,	other	112180921(+)	`TTTAAC/TATTTT`	3	--	ut3¹		8		NA EA	388
rs3733961^1,2	C,F,A,H,	other	112181283(-)	`TAATCG/ATATTA`	3	--	ut3¹ ese³		20		EA NS NA WA	3958
rs448475^1,2	C,F,O,A,H,	other	112181379(-)	`TATAAC/GGGGAC`	3	--	ut3¹ ese³		13		MN NA EA	934
rs397768^1,2	C,F,A,H,	other	112181576(+)	`GGGAGA/GGAAAA`	3	--	ut3¹ ese³ trp³		14		MN NA WA CSA EA	697
rs433429^1,2	C,F,O,A,H,	other	112182232(+)	`TAGAGT/ATAGTG`	4	--	ds500¹		15		NA WA CSA EA	517
rs386830^1,2	C,F,A,H,	other	112182379(-)	`AACTCT/CTGACT`	4	--	ds500¹		14		NA WA CSA EA	515
rs78002373^1,2	C	other	160591903(+)	`GGGGGA/GGGGAG`	4	--	ds500¹		0	--	--	--	--
rs76130955^1,2	C	other	160591947(+)	`GTTGGA/GAATTA`	4	--	ds500¹		0	--	--	--	--
rs77333076^1,2	C	other	160591950(+)	`CAGCGG/TTGGGA`	4	--	ds500¹		0	--	--	--	--
rs75293893^1,2	C	other	160592196(+)	`GAACAG/TTCCAC`	4	--	ds500¹		0	--	--	--	--
rs77843403^1,2	C	other	160592198(+)	`ATGAAC/GATTCC`	4	--	ds500¹		0	--	--	--	--
rs78516426^1,2	C	other	160592204(+)	`AATGAA/TCATTC`	4	--	ds500¹		0	--	--	--	--
rs77939672^1,2	C	other	160646233(+)	`AAGTGG/TTAGCC`	4	--	int¹		0	--	--	--	--
rs79526587^1,2	C	other	160646243(+)	`CTGAGC/TTTTTA`	4	--	int¹		0	--	--	--	--
rs79949837^1,2	C,F,	other	160647956(+)	`AGTTTT/CCTGTT`	4	--	int¹		3		WA NA EA	358
rs75205995^1,2	C	other	160647991(+)	`CGTGAC/GCCACC`	4	--	int¹		0	--	--	--	--
rs78017053^1,2	C	other	160648636(+)	`CATCCC/TCCCTC`	4	--	int¹		0	--	--	--	--
rs77271824^1,2	C	other	160648639(+)	`AGCCAA/C/TCCTCC`	4	--	int¹		0	--	--	--	--
rs76425429^1,2	C	other	160648734(+)	`TTTTTC/TCTATT`	4	--	int¹		0	--	--	--	--
rs1734242^1,2	C,F,O,H,	other	160648882(+)	`TAGGAA/GGTACT`	4	--	int¹		15		EA NA NS WA CSA	996
rs77979361^1,2	C,	other	160649198(+)	`GGCTTC/TTTCTA`	4	--	int¹		0	--	--	--	--
rs75822244^1,2	C	other	160651708(+)	`TTTTTC/TTTTTT`	4	--	int¹		0	--	--	--	--
rs76903962^1,2	C	other	160653330(+)	`GGTTTG/TCCTAG`	4	--	int¹		0	--	--	--	--
rs78971133^1,2	C,	other	160655090(+)	`CAACCA/CTGCCA`	4	--	int¹		3		CSA WA EA	240
rs76061636^1,2	C,	other	160655165(+)	`AAATGT/GTGGTA`	4	--	int¹		3		CSA WA EA	240
rs2431512^1,2	C,F,O,A,H,	other	160655341(+)	`TGATAC/TTGTCA`	4	--	int¹		21		NS EA NA WA	2522
rs2431242^1,2	C,F,O,A,	other	160656102(+)	`TCATAA/GTGAAG`	4	--	int¹		12		NA CSA WA EA	504
rs80191777^1,2	C	other	160657125(+)	`ATGTTC/TTAAAG`	4	--	int¹		0	--	--	--	--
rs2289484^1,2	C,F,A,H,	other	160657524(-)	`AACTAT/CGTGAA`	4	--	int¹		23		NS EA NA CSA WA	2420
rs2289485^1,2	C,F,H,	other	160657568(-)	`CTTATT/GTTGAA`	4	--	int¹		11		NS EA CSA WA	1538
rs77090722^1,2	C	other	160683776(+)	`AACAAC/GCAGCC`	4	--	int¹		0	--	--	--	--
rs79234413^1,2	C	other	160683779(+)	`AAAAAA/CAAGCA`	4	--	int¹		0	--	--	--	--
rs76865148^1,2		other	160683785(+)	`TTCTTA/TAAAAA`	4	--	int¹		0	--	--	--	--
rs78810609^1,2	C	other	160683973(+)	`GAAGGC/GAAATG`	4	--	int¹		0	--	--	--	--
rs74698368^1,2	C	other	160684689(+)	`TATTTG/TTTCCA`	4	--	int¹		0	--	--	--	--
rs11241183^1,2	C,F,A,H,	other	160685011(+)	`GACTTT/CTGTAG`	4	--	int¹		11		NA WA EA	510
rs6891448^1,2	C,F,H,	other	160685689(+)	`AAGAGT/GTGATT`	4	--	int¹		7		NS EA WA NA	776
rs11950612^1,2	C,F,H,	other	160687419(+)	`ATTCCC/TCAGAT`	4	--	int¹		16		NS EA CSA WA	2192
rs80288037^1,2	C	other	160688362(+)	`GATTAA/CAAGCA`	4	--	int¹		0	--	--	--	--
rs75848865^1,2	C,F,	other	160688797(+)	`GTTGTA/GGAACT`	4	--	int¹		2		WA EA	238
rs75448677^1,2	C	other	160689045(+)	`TCTTGC/GCTTAC`	4	--	int¹		0	--	--	--	--
rs79280419^1,2	C	other	160689962(+)	`GGCGGA/GTCACT`	4	--	int¹		0	--	--	--	--
rs78383074^1,2	C	other	160691349(+)	`GAAAAA/CCCTGG`	4	--	int¹		0	--	--	--	--
rs2112210^1,2	C,	other	160691353(+)	`GGGGGA/GAAACC`	4	--	int¹ trp³		0	--	--	--	--
rs75603862^1,2	C	other	160691426(+)	`CAACTA/CAAATA`	4	--	int¹		0	--	--	--	--
rs76147666^1,2	C,	other	160692205(+)	`AGCATA/C/TAGCTT`	4	--	int¹		0	--	--	--	--
rs77399711^1,2	C	other	160692609(+)	`TTTTGG/TTAAAC`	4	--	int¹		0	--	--	--	--
rs80193344^1,2	C	other	160692610(+)	`GTTTTG/TGTAAA`	4	--	int¹		0	--	--	--	--
rs79482241^1,2	C	other	160692883(+)	`GCGGGG/TGCCAC`	4	--	int¹		0	--	--	--	--
rs79334785^1,2	C,F,	other	160692917(+)	`ACCCCC/ACCACC`	4	--	int¹		2		NA EA	240
rs77054573^1,2	C	other	160693468(+)	`TGCTGG/TTCAGT`	4	--	int¹		0	--	--	--	--
rs79655915^1,2	C	other	160693469(+)	`ATGCTA/GGTCAG`	4	--	int¹		0	--	--	--	--
rs76978459^1,2	C	other	160693868(+)	`AAGTGA/TGGAGA`	4	--	int¹		0	--	--	--	--
rs10071425^1,2	C,F,	other	160694414(+)	`AACACG/TCCCTT`	4	--	int¹		8		NA EA	388
rs80063288^1,2		other	160695171(+)	`TTTTTA/TAAGCT`	4	--	int¹		0	--	--	--	--
rs79278712^1,2		other	160696003(+)	`CTATTG/TGCAAG`	4	--	int¹		0	--	--	--	--
rs4705610^1,2	C,F,A,H,	other	160696375(+)	`AGTTTC/GTGATG`	4	--	int¹		108		NS EA NA PA EU CA WA	6848
rs7706623^1,2	C,F,A,H,	other	160696614(+)	`ATGTTC/TCATTG`	4	--	int¹		18

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APC Gene

adenomatous polyposis coli

Aliases
for APC gene

Summaries
for APC gene

Genomic Views
for APC gene

Proteins
for APC gene

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Families
for APC gene

Function
for APC gene

Pathways & Interactions
for APC gene

Drugs & Compounds
for APC gene

Transcripts
for APC gene

Expression
for APC gene

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for APC gene

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for APC gene

Genomic Variants
for APC gene

Advanced Search

Export list of displayed genes

APC Gene

adenomatous polyposis coli

Aliasesfor APC gene

Summariesfor APC gene

Genomic Viewsfor APC gene

Proteinsfor APC gene

Protein Domains /Familiesfor APC gene

Functionfor APC gene

Pathways & Interactionsfor APC gene

Drugs & Compoundsfor APC gene

Transcriptsfor APC gene

Expression for APC gene

Orthologsfor APC gene

Paralogsfor APC gene

Genomic Variantsfor APC gene

Aliases
for APC gene

Summaries
for APC gene

Genomic Views
for APC gene

Proteins
for APC gene

Protein Domains /
Families
for APC gene

Function
for APC gene

Pathways & Interactions
for APC gene

Drugs & Compounds
for APC gene

Transcripts
for APC gene

Expression
for APC gene

Orthologs
for APC gene

Paralogs
for APC gene

Genomic Variants
for APC gene