Set Analyses:
Advanced Search

Advanced Search

Search By
Section (entire)


APC Gene

protein-coding   GIFtS: 71
GCID: GC05P112101

Adenomatous Polyposis Coli

(Previous name: adenomatosis polyposis coli)
  See APC-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Adenomatous Polyposis Coli1 2     DP22
Deleted In Polyposis 2.52 3     DP32
DP2.52 3     PPP1R462
BTPS22 5     Adenomatosis Polyposis Coli Tumor Suppressor2
GS2 5     Adenomatous Polyposis Coli Protein2
Adenomatosis Polyposis Coli1     Protein Phosphatase 1, Regulatory Subunit 462
Protein Phosphatase 11     Protein APC3
Regulatory Subunit 461     FPC5

External Ids:    HGNC: 5831   Entrez Gene: 3242   Ensembl: ENSG000001349827   OMIM: 6117315   UniProtKB: P250543   

Export aliases for APC gene to outside databases

Previous GC identifiers: GC05P111687 GC05P112537 GC05P112074 GC05P112149 GC05P107222

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APC Gene:
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also
involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis.
Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that
usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated
the mutation cluster region (MCR) and result in a truncated protein product. (provided by RefSeq, Jul 2008)

GeneCards Summary for APC Gene:
APC (adenomatous polyposis coli) is a protein-coding gene. Diseases associated with APC include apc-associated polyposis conditions, and fourth cranial nerve palsy. GO annotations related to this gene include beta-catenin binding and protein kinase binding. An important paralog of this gene is APC2.

UniProtKB/Swiss-Prot: APC_HUMAN, P25054
Function: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative
regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and
ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation
via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of
microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this
localization of MACF1 is critical for its function in microtubule stabilization

Gene Wiki entry for APC (Adenomatous polyposis coli) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the APC gene promoter:
         TBP   STAT5B   Spz1   NF-1   NF-1/L   C/EBPbeta   MyoD   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): APC promoter sequence
   Search Chromatin IP Primers for APC

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21-q22   Ensembl cytogenetic band:  5q22.2   HGNC cytogenetic band: 5q21-q22

APC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APC gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P112101:  view genomic region     (about GC identifiers)

112,043,195 bp from pter      End:
112,181,936 bp from pter
138,742 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: APC_HUMAN, P25054 (See protein sequence)
Recommended Name: Adenomatous polyposis coli protein  
Size: 2843 amino acids; 311646 Da
Subunit: Forms homooligomers and heterooligomers with APC2. Interacts with DIAPH1 and DIAPH2 (By similarity).
Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with ARHGEF4 (via
N-terminus). Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing
microtubule plus ends. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of
ARHGEF4, APC and CTNNB1. Interacts with SCRIB; may mediate APC targeting to adherens junctions of epithelial
cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain). Found in a
complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts at the cell membrane with
AMER1 and AMER2 (via ARM repeats)
Miscellaneous: APC mutations have led to some interesting observations. (1) the great majority of the mutations
found to date would result in truncation of the APC product. (2) almost all the mutations have occurred within
the first half of the coding sequence, and somatic mutations in colorectal tumors are further clustered in a
particular region, called MCR (mutation cluster region). (3) most identified point mutations in the APC gene are
transitions from cytosine to other nucleotides. (4) the location of germline mutations tends to correlate with
the number of colorectal polyps in FAP patients. Inactivation of both alleles of the APC gene seems to be
required as an early event to develop most adenomas and carcinomas in the colon and rectum as well as some of
those in the stomach
Selected PDB 3D structures from and Proteopedia for APC (see all 17):
1DEB (3D)        1EMU (3D)        1JPP (3D)        1M5I (3D)        1T08 (3D)        1TH1 (3D)    
Secondary accessions: D3DT03 Q15162 Q15163 Q93042
Alternative splicing: 2 isoforms:  P25054-1   P25054-2   

Explore the universe of human proteins at neXtProt for APC: NX_P25054

Explore proteomics data for APC at MOPED

Post-translational modifications: 

  • Phosphorylated by GSK3B1
  • Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin.
    Deubiquitinated by ZRANB1/TRABID1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See APC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000029.2  NP_001120982.1  NP_001120983.2  

    ENSEMBL proteins: 
     ENSP00000426541   ENSP00000423224   ENSP00000424265   ENSP00000257430   ENSP00000427089  
     ENSP00000423828   ENSP00000473355   ENSP00000413133  
    Reactome Protein details: P25054

    APC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for APC
    OriGene Custom MassSpec
    OriGene Custom Protein Services for APC
    GenScript Custom Purified and Recombinant Proteins Services for APC
    Novus Biologicals APC Protein
    Novus Biologicals APC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for APC

    Search eBioscience for Proteins for APC 

    antibodies-online proteins for APC (6 products) 

    antibodies-online peptides for APC

    Search GeneTex for Proteins for APC 

    APC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of APC
    R&D Systems Antibodies for APC
    Cell Signaling Technology (CST) Antibodies for APC 
    OriGene Antibodies for APC
    OriGene Custom Antibody Services for APC
    Novus Biologicals APC Antibodies
    Abcam antibodies for APC
    Cloud-Clone Corp. Antibodies for APC
    ThermoFisher Antibody for APC
    antibodies-online antibodies for APC (128 products) 

    GeneTex Antibodies for APC:  
                        APC Antibodies

    APC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for APC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for APC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for APC
    Cloud-Clone Corp. CLIAs for APC
    Search eBioscience for ELISAs for APC 
    antibodies-online kits for APC (16 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    ARMC: Armadillo repeat containing
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    Selected InterPro protein domains (see all 11):
     IPR011989 ARM-like
     IPR009224 SAMP
     IPR000225 Armadillo
     IPR009232 EB1-bd
     IPR026831 APC_dom

    Graphical View of Domain Structure for InterPro Entry P25054

    ProtoNet protein and cluster: P25054

    1 Blocks protein domain: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: APC_HUMAN, P25054
    Domain: The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to
    the growing microtubule plus ends (By similarity)
    Similarity: Belongs to the adenomatous polyposis coli (APC) family
    Similarity: Contains 7 ARM repeats

    Find genes that share domains with APC           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APC_HUMAN, P25054
    Function: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative
    regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and
    ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation
    via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of
    microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this
    localization of MACF1 is critical for its function in microtubule stabilization

         Genatlas biochemistry entry for APC:
    multidomain protein,binding beta-catenin and regulating free beta-catenin level,involved in cell adhesion and
    active cell migration,mutated in adenomatous polyposis coli,colon and rectum carcinoma non polyposis,modulating
    the frequency and classes of mutation leading to colon polyps

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI10656683
    GO:0008013beta-catenin binding IPI10773885
    GO:0008017microtubule binding IDA11166179
    GO:0019887protein kinase regulator activity IDA11972058
    Find genes that share ontologies with APC           About GenesLikeMe

         3 GenomeRNAi human phenotypes for APC:
     Decreased POU5F1-GFP protein e  Decreased focal adhesion (FA)   Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 26 alleles(MGI details for Apc) (see all 27):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 

    Find genes that share phenotypes with APC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for APC: Apctm1.1Tyj Apctm4Mmt Apctm1Cip Apctm1Rak Apctm1.1Tno Apctm1Mmt
                                                         Apctm1Hsa Apctm1.1Ecrm Apctm2.1Rak

       genOway: Develop your customized and physiologically relevant rodent model for APC

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for APC

    miRTarBase miRNAs that target APC:
    hsa-mir-215-5p (MIRT024577), hsa-mir-21-5p (MIRT031054), hsa-mir-148a-3p (MIRT048033), hsa-mir-186-5p (MIRT045069), hsa-mir-210-3p (MIRT003183), hsa-mir-155-5p (MIRT001207), hsa-mir-192-5p (MIRT026886), hsa-mir-27a-3p (MIRT006221), hsa-mir-106b-5p (MIRT007071)

    Block miRNA regulation of human, mouse, rat APC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APC (see all 112):
    hsa-miR-579 hsa-miR-520e hsa-miR-300 hsa-miR-374a hsa-miR-519a hsa-miR-3916 hsa-miR-502-3p hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidAPC 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for APC
    Predesigned siRNA for gene silencing in human, mouse, rat APC

    OriGene clones in human, mouse for APC (see all 13)
    OriGene ORF clones in mouse, rat for APC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): APC (NM_001127510)
    Browse Sino Biological Human cDNA Clones
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APC
    Addgene plasmids for APC 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for APC
    Browse ESI BIO Cell Lines and PureStem Progenitors for APC 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APC

    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-12377) for APC 

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    APC_HUMAN, P25054: Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium.
    Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Note=Associated with the microtubule network at the
    growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to
    hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the
    phosophorylated form to the cell membrane
    Subcellular locations from COMPARTMENTS: 

    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA11283619
    GO:0005634nucleus IDA11035805
    GO:0005737cytoplasm IDA11035805
    GO:0005813centrosome IDA11283619
    GO:0005829cytosol TAS--

    Find genes that share ontologies with APC           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for APC About   (see all 35)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Regulation of actin cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    3CDK-mediated phosphorylation and removal of Cdc6
    Degradation of beta-catenin by the destruction complex0.73
    Beta-catenin phosphorylation cascade0.00
    4Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    5Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.74
    Apoptotic execution phase0.74

    Find genes that share SuperPaths with APC           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for APC
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for APC (see all 11)
        Factors Promoting Cardiogenesis in Vertebrates
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Glioblastoma Multiforme

    1 Cell Signaling Technology (CST) Pathway for APC
        Wnt / Hedgehog / Notch

    Selected BioSystems Pathways for APC (see all 17)
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    Irinotecan Pathway
    Gastric cancer network 1

    5 Reactome Pathways for APC
        deactivation of the beta-catenin transactivating complex
    disassembly of the destruction complex and recruitment of AXIN to the membrane
    Apoptotic cleavage of cellular proteins
    Degradation of beta-catenin by the destruction complex
    Beta-catenin phosphorylation cascade

    Selected Kegg Pathways  (Kegg details for APC) (see all 9):
        Wnt signaling pathway
    Hippo signaling pathway
    Regulation of actin cytoskeleton
    HTLV-I infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including APC (see all 15): 
              Parkinson's Disease in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Multiple Sclerosis in human mouse rat
              WNT Signaling Pathway in human mouse rat


        GeneGlobe Interaction Network for APC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for APC (P250541, 2, 3 ENSP000002574304) via UniProtKB, MINT, STRING, and/or I2D (see all 530)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL1O146401, 2, 3, ENSP000003681694EBI-727707,EBI-723489 MINT-7897032 MINT-7897055 MINT-7897075 MINT-7897100 I2D: score=1 STRING: ENSP00000368169
    CTNNB1P352221, 2, 3, ENSP000003444564EBI-727707,EBI-491549 MINT-4508229 I2D: score=8 STRING: ENSP00000344456
    DVL1P1P547921, 2, 3EBI-727707,EBI-7848109 MINT-7891084 MINT-7891069 I2D: score=1 
    DVL2O146412, 3, ENSP000000053404MINT-7890898 MINT-7897032 MINT-7897075 I2D: score=2 STRING: ENSP00000005340
    PXNP490232, 3, ENSP000002283074MINT-7891130 MINT-7897100 I2D: score=2 STRING: ENSP00000228307
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 60):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IMP17570218
    GO:0001822kidney development IEA--
    GO:0001942hair follicle development IEA--
    GO:0006461protein complex assembly IDA16188939
    GO:0006915apoptotic process TAS--

    Find genes that share ontologies with APC           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APC

    Selected Novoseek inferred chemical compound relationships for APC gene (see all 88)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    af/ap 80.5 4 10494086 (2), 11786778 (1), 15623495 (1)
    crcs 74.3 10 11270422 (1), 17704924 (1), 11751382 (1), 14578138 (1) (see all 8)
    sulindac 60.9 8 11535846 (3), 12663524 (2), 19755659 (1), 8707116 (1)
    phip 60.7 17 19628463 (2), 9202752 (2), 11181456 (2), 9202738 (1) (see all 11)
    glycogen 59.9 144 19339242 (9), 9003374 (5), 10233043 (5), 12829248 (5) (see all 55)
    pphp 48.9 2 1621772 (1)
    1-hydroxyanthraquinone 48 3 9433483 (2), 10204808 (1)
    samp 47.7 3 10346819 (1), 10021369 (1), 10966653 (1)
    5-aza-2'deoxycytidine 46.1 5 17065059 (1), 15087381 (1), 15225415 (1), 18058533 (1) (see all 5)
    adenylate 38.1 15 2167212 (1), 10421220 (1), 1637317 (1), 8131796 (1) (see all 15)

    Find genes that share compounds with APC           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for APC gene (3 alternative transcripts): 
    NM_000038.5  NM_001127510.2  NM_001127511.2  

    Unigene Cluster for APC:

    Adenomatous polyposis coli
    Hs.158932  [show with all ESTs]
    Unigene Representative Sequence: NM_001127510
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509732 ENST00000505350 ENST00000507379 ENST00000508624 ENST00000257430(uc003kpz.4 uc003kpy.4 uc010jbz.3 uc010jca.3)
    ENST00000508376 ENST00000512211 ENST00000506342 ENST00000502371 ENST00000504915
    ENST00000505084 ENST00000514164 ENST00000457016(uc011cvt.2)
    Block miRNA regulation of human, mouse, rat APC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APC (see all 112):
    hsa-miR-579 hsa-miR-520e hsa-miR-300 hsa-miR-374a hsa-miR-519a hsa-miR-3916 hsa-miR-502-3p hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidAPC 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for APC
    Predesigned siRNA for gene silencing in human, mouse, rat APC
    OriGene clones in human, mouse for APC (see all 13)
    OriGene ORF clones in mouse, rat for APC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): APC (NM_001127510)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APC
    Addgene plasmids for APC 
    OriGene qSTAR qPCR primer pairs in human, mouse for APC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APC
      QuantiTect SYBR Green Assays in human, mouse, rat APC
      QuantiFast Probe-based Assays in human, mouse, rat APC
    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-12377) for APC 

    Additional mRNA sequence: 

    AB210001.1 AF038181.1 AK289567.1 AK294544.1 AK309033.1 BC034955.1 BC056268.1 M73548.1 
    M74088.1 S56365.1 S67787.1 S67788.1 S67789.1 

    15 DOTS entries:

    DT.99981468  DT.120809542  DT.40310104  DT.95121675  DT.99962531  DT.119384  DT.95374795  DT.120809704 
    DT.120809770  DT.452608  DT.449103  DT.91757887  DT.100721411  DT.432665  DT.91950191 

    Selected AceView cDNA sequences (see all 445):

    BQ549628 BE256854 AL706482 BM791285 CA313732 BM723345 AI566022 BM930344 
    AL535988 AA421913 F01948 BX100792 F05691 BQ182033 AA033768 AA376964 
    F12582 BM977243 BG985951 BM987992 NM_005083 F09958 BF001542 BI333071 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for APC    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                                                                              -               
    SP2:              -                                                                                                               

    ECgene alternative splicing isoforms for APC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    APC Expression
    About this image

    APC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     Brain (Nervous System)    fully expand to see all 6 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     Spinal Cord (Nervous System)
             Myelinating Oligodendrocyte Cells Spinal Cord White Matter
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     Primitive Streak (Early Embryonic Tissues)
             Primitive Streak Cells Anterior Primitive Streak
    APC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158932

    UniProtKB/Swiss-Prot: APC_HUMAN, P25054
    Tissue specificity: Expressed in a variety of tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including APC (see all 15): 
              Parkinson's Disease in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Lung Cancer in human mouse rat
              Multiple Sclerosis in human mouse rat
              WNT Signaling Pathway in human mouse rat

    OriGene qSTAR qPCR primer pairs in human, mouse for APC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APC
    QuantiTect SYBR Green Assays in human, mouse, rat APC
    QuantiFast Probe-based Assays in human, mouse, rat APC
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for APC gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Apc1 , 5 adenomatosis polyposis coli1, 5 87.53(n)1
      18 (18.53 cM)5
    117891  NM_007462.31  NP_031488.21 
    (Gallus gallus)
    Aves APC1 adenomatous polyposis coli 80.62(n)
      415607  XM_004949283.1  XP_004949340.1 
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    many ↔ many
    many ↔ many
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84362 Xenopus laevis adenomatous polyposis coli mRNA, complete more 78.78(n)    U64442.1 
    (Danio rerio)
    Actinopterygii apc1 adenomatosis polyposis coli 66.85(n)
      386762  NM_001143840.1  NP_001137312.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Apc3 frizzled-2 receptor signaling pathway
    microtubule more
    (best of 2)
    (Caenorhabditis elegans)
    Secernentea apr-16
    Protein APR-1, isoform b (apr-1) mRNA, complete cd...
    1 → many
    I(8050043-8055474) WBGene00000156

    ENSEMBL Gene Tree for APC (if available)
    TreeFam Gene Tree for APC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for APC gene
    APC22  ENSG000002588642  
    2 SIMAP similar genes for APC using alignment to 26 protein entries:     APC_HUMAN (see all proteins):
    APC variant protein    APC2

    Find genes that share paralogs with APC           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for APC (see all 4088)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 5 posSequence#AA
    C,FFamilial adenomatous polyposis (FAP)4 pathogenic1112435736(+) AGATAC/TGCGCT 6 R C mis12Minor allele frequency- T:0.00NA EU 5871
    C,FFamilial adenomatous polyposis (FAP)4 --112460025(+) ATTTTC/GTCCCA 6 S C mis17Minor allele frequency- G:0.30EU NA 7221
    Familial adenomatous polyposis (FAP)4--see VAR_0096142 S G mis40--------
    Familial adenomatous polyposis (FAP)4--see VAR_0096162 A P mis40--------
    Gastric cancer (GASC)4--see VAR_0050452 F S mis40--------
    Gastric cancer (GASC)4--see VAR_0050502 G E mis40--------
    Familial adenomatous polyposis (FAP)4--see VAR_0050512 T A mis40--------
    Gastric cancer (GASC)4--see VAR_0050352 G C mis40--------
    Medulloblastoma (MDB)4--see VAR_0176552 S G mis40--------
    Gastric cancer (GASC)4--see VAR_0050522 V A mis40--------

    HapMap Linkage Disequilibrium report for APC (112043195 - 112181936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for APC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4959CNV Insertion18451855
    nsv462387CNV Loss19166990
    nsv830450CNV Gain17160897

    Human Gene Mutation Database (HGMD): APC
    Locus Specific Mutation Databases (LSDB): APC

    Selected Site Specific Mutation Identification with PCR Assays for APC (see all 63):
    Cosmic IdAA Change
    Selected Site Specific Cancer Mutation PCR Panels containing APC (see all 10):
    Breast Cancer
    Cancer Comprehensive Panel 384HT
    APC/CTNNB1 Pathway
    Soft Tissue Tumors
    Tumor Suppressor Panel 384HT
    2 Copy Number PCR Panels containing APC:
    Oncogenes & Tumor Suppressor Genes 384HC
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing APC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 611731   
    OMIM disorders: 175100  613659  114550  135290  114500  
    UniProtKB/Swiss-Prot: APC_HUMAN, P25054
  • Familial adenomatous polyposis (FAP) [MIM:175100]: A cancer predisposition syndrome characterized by
    adenomatous polyps of the colon and rectum, but also of upper gastrointestinal tract (ampullary, duodenal and
    gastric adenomas). This is a viciously premalignant disease with one or more polyps progressing through dysplasia
    to malignancy in untreated gene carriers with a median age at diagnosis of 40 years. Note=The disease is caused
    by mutations affecting the gene represented in this entry
  • Hereditary desmoid disease (HDD) [MIM:135290]: Autosomal dominant trait with 100% penetrance and possible
    variable expression among affected relatives. HDD patients show multifocal fibromatosis of the paraspinal
    muscles, breast, occiput, arms, lower ribs, abdominal wall, and mesentery. Desmoid tumors appears also as a
    complication of familial adenomatous polyposis. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Medulloblastoma (MDB) [MIM:155255]: Malignant, invasive embryonal tumor of the cerebellum with a
    preferential manifestation in children. Note=The gene represented in this entry may be involved in disease
  • Mismatch repair cancer syndrome (MMRCS) [MIM:276300]: Autosomal dominant disorder characterized by
    malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous
    cysts, hyperpigmented and cafe au lait spots. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the
    esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It
    also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to
    adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types
    are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated
    infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually
    exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in
    sporadic disease. Note=The gene represented in this entry may be involved in disease pathogenesis
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The
    major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV)
    infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Note=The
    gene represented in this entry may be involved in disease pathogenesis

  • Selected diseases for APC (see all 40):    
    About MalaCards
    apc-associated polyposis conditions    fourth cranial nerve palsy    cranial nerve palsy    brain tumor-polyposis syndrome 2
    gardner syndrome    desmoid tumor    familial adenomatous polyposis    hepatoblastoma
    familial adenomatous polyposis due to 5q22.2 microdeletion    hepatoblastoma, somatic    adenoma, periampullary, somatic    liver cancer
    medulloblastoma    intestinal neoplasm    attenuated familial adenomatous polyposis    fibrous dysplasia
    cerebellar liponeurocytoma    colorectal cancer    intussusception    turcot syndrome

    5 inferred disease relationships from the University of Copenhagen DISEASES database for APC:
    Familial adenomatous polyposis     Colorectal cancer     Adenoma     Intestinal neoplasm

    Find genes that share disorders with APC           About GenesLikeMe

    Selected Novoseek inferred disease relationships for APC gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    familial adenomatous polyposis 96.7 454 15793634 (4), 8835324 (4), 15540296 (4), 11786778 (3) (see all 99)
    polyposis 89.7 92 17568392 (6), 11867715 (4), 15761860 (3), 11868006 (2) (see all 58)
    colorectal cancer 85.6 236 8835324 (6), 15375009 (5), 11211307 (4), 11135372 (4) (see all 99)
    adenoma 85.1 218 8012980 (6), 12673484 (6), 12163385 (6), 10440612 (5) (see all 99)
    colorectal tumors 83.1 44 10737795 (3), 10921028 (3), 10493496 (2), 9724771 (2) (see all 35)
    microsatellite instability 83.1 54 9924427 (2), 11819821 (2), 12378616 (2), 11107173 (2) (see all 47)
    desmoid tumor 81.7 59 15793634 (6), 18646694 (3), 18854359 (3), 10782927 (3) (see all 24)
    turcot syndrome 81.1 14 7515658 (2), 7662026 (1), 9641305 (1), 11005140 (1) (see all 10)
    adenomatous polyps 79.4 11 14502807 (2), 7559732 (1), 12833148 (1), 14578138 (1) (see all 10)
    germ-line mutation 78.5 41 11867715 (3), 1316610 (2), 15857185 (2), 11754114 (2) (see all 32)

    GeneTests: APC
    GeneReviews: APC
    Genetic Association Database (GAD): APC
    Human Genome Epidemiology (HuGE) Navigator: APC (236 documents)
    Tumor Gene Database (TGDB): APC

    Export disorders for APC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APC gene, integrated from 10 sources (see all 1628) (see top 10):
    (articles sorted by number of sources associating them with APC)

    1. The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. (PubMed id 9724771)1, 2, 4, 9 Frayling I.M.... Tomlinson I.P.M. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. (PubMed id 10782927)1, 2, 4, 9 Couture J.... Bapat B. (Clin. Genet. 2000)
    3. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. (PubMed id 1651563)1, 2, 3, 9 Nishisho I.... Vogelstein B. (Science 1991)
    4. Relative role of APC and MUTYH mutations in the pathogenesis of familial adenomatous polyposis. (PubMed id 19593690)1, 4, 9 Pezzi A....Ponz De Leon M. (Scand. J. Gastroenterol. 2009)
    5. APC and CTNNB1 mutations are rare in sporadic ependymomas. (PubMed id 16843107)1, 4, 9 Onilude O.E....Clifford S.C. (Cancer Genet. Cytogenet. 2006)
    6. [The I1307K mutation and protein expression of APC gene in gastric cancer]. (PubMed id 15639864)1, 4, 9 Sun X.J....Sun K.L. (Yi Chuan 2003)
    7. Molecular analysis of the APC and MUTYH genes in Galician and Catalonian FAP families: a different spectrum of mutations? (PubMed id 19531215)1, 4, 9 GA^mez-FernA!ndez N....Ruiz-Ponte C. (BMC Med. Genet. 2009)
    8. [Polymorphism/loss of heterozygosity of APC gene in GERD-Barrett's metaplasia-dysplasia-adenocarcinoma sequence]. (PubMed id 19606680)1, 4, 9 Mokrowiecka A....Malecka-Panas E. (Pol. Merkur. Lekarski 2009)
    9. Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer. (PubMed id 18992635)1, 4, 9 Bougatef K....Marrakchi R. (Cancer Genet. Cytogenet. 2008)
    10. APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia. (PubMed id 15507235)1, 4, 9 KapitanoviA8 S....PaveliA8 K. (Exp. Mol. Pathol. 2004)
    11. APC genotype is not a prognostic factor in familial adenomatous polyposis patients with colorectal cancer. (PubMed id 15540296)1, 4, 9 Bertario L....Radice P. (Dis. Colon Rectum 2004)
    12. Mutations of the APC (adenomatous polyposis coli) gene. (PubMed id 8111410)1, 2, 9 Nagase H. and Nakamura Y. (Hum. Mutat. 1993)
    13. [Single nucleotide c.645+32c&gt;T substitution in the APC gene is a non-pathogenic polymorphism appearing in about 16% of the Czech population]. (PubMed id 18630182)1, 4, 9 PlevovA! P....SilhA!novA! E. (Cas. Lek. Cesk. 2008)
    14. Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis. (PubMed id 18091433)1, 4, 9 Cattaneo F.... Ranzani G.N. (Genet. Med. 2007)
    15. Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. (PubMed id 16356174)1, 4, 9 LA1chtenborg Goeij A.F. (BMC Cancer 2005)
    16. Relationship between APC genotype, polyp distribution, and oral sulindac treatment in the colon and rectum of patients with familial adenomatous polyposis. (PubMed id 11535846)1, 4, 9 Guldenschuh I....Scott R.J. (Dis. Colon Rectum 2001)
    17. Identification of FAP locus genes from chromosome 5q21. (PubMed id 1651562)1, 2, 9 Kinzler K.W.... Nakamura Y. (Science 1991)
    18. Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease. (PubMed id 19543899)1, 4, 9 Rapozo D.C....Pinto L.F. (Int J Colorectal Dis 2009)
    19. No evidence of the APC D1822V missense variant's pathogenicity in Tunisian patients with sporadic colorectal cancer. (PubMed id 18343606)1, 4, 9 Bougatef K....Ben Ammar Elgaaied A. (Pathol. Biol. 2009)
    20. Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations. (PubMed id 15761860)1, 4, 9 Kairupan C.F....Scott R.J. (Int. J. Cancer 2005)
    21. [Increased sensitivity for detection of mutations in exon 15 of the APC gene in patients with familial adenomatous polyposis]. (PubMed id 15446460)1, 4, 9 Konvalinka D....SantavA1 J. (Cas. Lek. Cesk. 2004)
    22. Prevalence of the E1317Q variant of the APC gene in Italian patients with colorectal adenomas. (PubMed id 12537656)1, 4, 9 Gismondi V....Varesco L. (Genet. Test. 2002)
    23. Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis. (PubMed id 11241320)1, 4, 9 Bertario L....Radice P. (Int. J. Cancer 2001)
    24. Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein. (PubMed id 9188857)1, 2, 9 Makino K.... Saya H. (Oncogene 1997)
    25. Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene. (PubMed id 8940264)1, 2, 9 Eccles D.M.... Fodde R. (Am. J. Hum. Genet. 1996)
    26. Association of the APC gene product with beta-catenin. (PubMed id 8259518)1, 4, 9 Rubinfeld B....Polakis P. (Science 1993)
    27. Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. (PubMed id 1310068)1, 2, 9 Miki Y.... Nakamura Y. (Cancer Res. 1992)
    28. Introduction of cytogenetic tests in colorectal cancer screening. (PubMed id 19337631)1, 4, 9 Suceveanu A.I....Adam T. (J Gastrointestin Liver Dis 2009)
    29. Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. (PubMed id 18708403)1, 4, 9 Wang X....Couch F.J. (amp 2008)
    30. Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants. (PubMed id 18375958)1, 4, 9 Theodoratou E....Farrington S.M. (Carcinogenesis 2008)
    31. Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families. (PubMed id 18433509)1, 4, 9 Kanter-Smoler G....Nordling M. (BMC Med 2008)
    32. How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population. (PubMed id 17854661)1, 4, 9 Dundar M....Ozkul Y. (Cancer Genet. Cytogenet. 2007)
    33. Novel APC mutations in Czech and Slovak FAP families: clinical and genetic aspects. (PubMed id 17411426)1, 4, 9 Stekrova J....Kohoutova M. (BMC Med. Genet. 2007)
    34. Familial adenomatous polyposis (FAP): genotype correlation to FAP phenotype with osteomas and sebaceous cysts. (PubMed id 16411234)1, 4, 9 Bisgaard M.L. and BA1low S. (Am. J. Med. Genet. A 2006)
    35. Genotype phenotype correlations in Israeli colorectal cancer patients. (PubMed id 15523694)1, 4, 9 Starinsky S....Friedman E. (Int. J. Cancer 2005)
    36. Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasms. (PubMed id 15959913)1, 4, 9 Zauber N.P....Bishop D.T. (Cancer 2005)
    37. Definition of candidate low risk APC alleles in a Swedish population. (PubMed id 15122587)1, 4, 9 Zhou X.L....Lindblom A. (Int. J. Cancer 2004)
    38. APC I1307K and the E1317Q variants are not present in Chinese colorectal cancer patients. (PubMed id 15266213)1, 4, 9 Guo J....Lee S.C. (Genet. Med. 2004)
    39. The APC E1317Q variant in adenomatous polyps and colorectal cancers. (PubMed id 14578138)1, 4, 9 Hahnloser D....Thibodeau S.N. (amp 2003)
    40. The influence of mutation site and age on the severity of duodenal polyposis in patients with familial adenomatous polyposis. (PubMed id 11868006)1, 4, 9 Saurin J.C....Chayvialle J.A. (Gastrointest. Endosc. 2002)
    41. APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews. (PubMed id 11159880)1, 4, 9 Stern H.S....Lagarde A.E. (Gastroenterology 2001)
    42. Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism. (PubMed id 9973276)1, 2, 9 Gryfe R.... Redston M. (Am. J. Hum. Genet. 1999)
    43. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. (PubMed id 8638125)1, 2, 9 Matsumine A.... Akiyama T. (Science 1996)
    44. Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility. (PubMed id 21871439)1, 2 Zhang Z.... Wu G. (Biochem. Biophys. Res. Commun. 2011)
    45. Combined iPLEX and TaqMan assays to screen for 45 common mutations in Lynch syndrome and FAP patients. (PubMed id 20007843)1, 4 Dymerska D....Kurzawski G. (J Mol Diagn 2010)
    46. Risk factors predicting intra-abdominal desmoids in familial adenomatous polyposis: a single centre experience. (PubMed id 20352275)1, 4 Sinha A....Clark S.K. (Tech Coloproctol 2010)
    47. Increased cancer predisposition in family members of colorectal cancer patients harboring the p.V600E BRAF mutation: a population-based study. (PubMed id 20570909)1, 4 Wish T.A....Green R.C. (amp 2010)
    48. Common variants in human CRC genes as low-risk alleles. (PubMed id 20149637)1, 4 Picelli S....Lindblom A. (Eur. J. Cancer 2010)
    49. APC mutations are associated with increased bone mineral density in patients with familial adenomatous polyposis. (PubMed id 20564245)1, 4 Miclea R.L....Hamdy N.A. (J. Bone Miner. Res. 2010)
    50. Mutation analysis of the APC gene in Taiwanese FAP families: low incidence of APC germline mutation in a distinct subgroup of FAP families. (PubMed id 19768578)1, 4 Chiang J.M....Wang J.Y. (Fam. Cancer 2010)
    51. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    52. Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. (PubMed id 20613673)1, 4 Lee D.Y....Kim J.G. (Menopause 2010)
    53. The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. (PubMed id 20437058)1, 4 Hawken S.J....Little J. (Hum. Genet. 2010)
    54. Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (PLoS ONE 2010)
    55. Polymorphisms in the adenomatous polyposis coli (APC) gene and advanced colorectal adenoma risk. (PubMed id 20510605)1, 4 Wong H.L....Brody L.C. (Eur. J. Cancer 2010)
    56. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    57. Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome. (PubMed id 20056645)1, 4 Couch F.J....McWilliams R.R. (amp 2010)
    58. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    59. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    60. Association analysis of Wnt pathway genes on prostate-specific antigen recurrence after radical prostatectomy. (PubMed id 19777185)1, 4 Huang S.P....Bao B.Y. (Ann. Surg. Oncol. 2010)
    61. Genotype predicting phenotype in familial adenomatous polyposis: a practical application to the choice of surgery. (PubMed id 19571702)1, 4 Nieuwenhuis M.H....Vasen H.F. (Dis. Colon Rectum 2009)
    62. Risk of colorectal neoplasia associated with the adenomatous polyposis coli E1317Q variant. (PubMed id 19474113)1, 4 Hall M.J....Arber N. (Ann. Oncol. 2009)
    63. Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas. (PubMed id 19527492)1, 4 Nielsen M....Morreau H. (BMC Cancer 2009)
    64. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    65. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    66. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PubMed id 19351817)1, 4 Blackford A....Hruban R.H. (Cancer Res. 2009)
    67. Prognostic significance of interaction between somatic APC mutations and 5-fluorouracil adjuvant chemotherapy in Taiwanese colorectal cancer subjects. (PubMed id 19307944)1, 4 Chen S.P....Harn H.J. (Am. J. Clin. Oncol. 2009)
    68. Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication. (PubMed id 18844223)1, 4 Kastritis E....Bamias A. (Int. J. Cancer 2009)
    69. APC, MYH, and the correlation genotype-phenotype in colorectal polyposis. (PubMed id 19169759)1, 4 Lefevre J.H....Tiret E. (Ann. Surg. Oncol. 2009)
    70. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    71. Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. (PubMed id 19151759)1, 2 Sagara M.... Akiyama T. (Oncogene 2009)
    72. Host single nucleotide polymorphisms of MMP-9 -1562/TIMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection. (PubMed id 19889076)1, 4 Hung K.H....Sheu B.S. (Helicobacter 2009)
    73. Analysis of candidate genes in occurrence and growth of colorectal adenomas. (PubMed id 19888426)1, 4 Olschwang S....Bonaiti-PelliAc C. (J Oncol 2009)
    74. Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. (PubMed id 18992263)1, 4 Slattery M.L....Samowitz W.S. (Mutat. Res. 2009)
    75. APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas. (PubMed id 19793053)1, 4 Filipe B....Nobre LeitALo C. (Clin. Genet. 2009)
    76. High detection rates of colorectal neoplasia by stool DNA testing with a novel digital melt curve assay. (PubMed id 19026650)1, 4 Zou H....Ahlquist D.A. (Gastroenterology 2009)
    77. Integrative approach for prioritizing cancer genes in sporadic colon cancer. (PubMed id 19672874)1, 4 Reid J.F....Pierotti M.A. (amp 2009)
    78. An EB1-binding motif acts as a microtubule tip localization signal. (PubMed id 19632184)1, 2 Honnappa S.... Steinmetz M.O. (Cell 2009)
    79. Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas. (PubMed id 18199528)1, 4 Azzopardi D....Cheadle J.P. (Cancer Res. 2008)
    80. APC gene mutations causing familial adenomatous polyposis in Polish patients. (PubMed id 19029688)1, 4 Plawski A. and Slomski R. (J. Appl. Genet. 2008)
    81. Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. (PubMed id 18612690)1, 4 Cleary S.P....Gryfe R. (Dis. Colon Rectum 2008)
    82. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    83. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    84. Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. (PubMed id 18281465)1, 2 Tran H.... Bienz M. (Genes Dev. 2008)
    85. Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis. (PubMed id 19013464)1, 4 Boparai K.S....van Noesel C.J. (Gastroenterology 2008)
    86. The APC E1317Q and I1307K polymorphisms in non-colorectal cancers. (PubMed id 17920230)1, 4 Liberman E....Arber N. (amp 2007)
    87. Association of adenomatous polyposis coli (APC) gene polymorphisms with autism spectrum disorder (ASD). (PubMed id 17221838)1, 4 Zhou X.L....Lindblom A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    88. MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas. (PubMed id 17252231)1, 4 Kim J.C....Lee K.H. (Virchows Arch. 2007)
    89. Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis. (PubMed id 17489848)1, 4 Nielsen M....Vasen H.F. (Clin. Genet. 2007)
    90. Genotype-phenotype correlations as a guide in the management of familial adenomatous polyposis. (PubMed id 17368237)1, 4 Nieuwenhuis M.H....Vasen H.F. (Clin. Gastroenterol. Hepatol. 2007)
    91. Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis. (PubMed id 17080006)1, 4 Walley K.R. and Russell J.A. (Crit. Care Med. 2007)
    92. The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese persons. (PubMed id 17556698)1, 4 Guerreiro C.S....LeitALo C.N. (Am. J. Clin. Nutr. 2007)
    93. Single nucleotide polymorphisms of the APC gene and colorectal cancer risk: a case-control study in Taiwan. (PubMed id 16569251)1, 4 Chen S.P....Harn H.J. (BMC Cancer 2006)
    94. Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. (PubMed id 16611247)1, 2 Takizawa S....Taketani Y. (Genes Cells 2006)
    95. APC I1307K and the risk of prostate cancer. (PubMed id 16537703)1, 4 Poynter J.N....Gruber S.B. (amp 2006)
    96. APC E1317Q is not associated with Colorectal Cancer in a population-based case-control study in Northern Israel. (PubMed id 17119068)1, 4 Rozek L.S....Gruber S.B. (amp 2006)
    97. Dietary folate and APC mutations in sporadic colorectal cancer. (PubMed id 17116713)1, 4 de Vogel S....Weijenberg M.P. (J. Nutr. 2006)
    98. Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas. (PubMed id 16545110)1, 4 SarebA...Kure E.H. (BMC Cancer 2006)
    99. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    100. [Detection of germline mutations in the APC gene with the protein truncation test]. (PubMed id 16201232)1, 4 Liu X.R....Wang Y.P. (Yi Chuan Xue Bao 2005)
    101. Colorectal polyps in carriers of the APC I1307K polymorphism. (PubMed id 16228836)1, 4 Rennert G....Gruber S.B. (Dis. Colon Rectum 2005)
    102. The I1307K APC mutation in a high-risk clinic setting: a follow-up study. (PubMed id 15733272)1, 4 Regev M....Friedman E. (Clin. Genet. 2005)
    103. Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). (PubMed id 16184469)1, 4 LA1chtenborg M....van den Brandt P.A. (amp 2005)
    104. APC Asp1822Val and Gly2502Ser polymorphisms and risk of colorectal cancer and adenoma. (PubMed id 15824157)1, 4 Tranah G.J....Hunter D.J. (amp 2005)
    105. A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history. (PubMed id 15951963)1, 4 Truta B....Terdiman J.P. (Fam. Cancer 2005)
    106. Adenomatous polyposis coli is down-regulated by the ubiquitin- proteasome pathway in a process facilitated by Axin. (PubMed id 15355978)1, 2 Choi J.... Joo C.-K. (J. Biol. Chem. 2004)
    107. First genotype characterization of Argentinean FAP patients: identification of 14 novel APC mutations. (PubMed id 15108288)1, 4 De Rosa M....Solano A.R. (Hum. Mutat. 2004)
    108. Inherited variants in MYH are unlikely to contribute to the risk of lung carcinoma. (PubMed id 14579148)1, 4 Al-Tassan N....Houlston R.S. (Hum. Genet. 2004)
    109. Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas. (PubMed id 15520370)1, 4 Fearnhead N.S....Bodmer W.F. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    110. Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation. (PubMed id 15542524)1, 4 Sturt N.J....Phillips R.K. (Gut 2004)
    111. Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: evidence of genetic drift within the Ashkenazim. (PubMed id 14624392)1, 4 Niell B.L....Gruber S.B. (Am. J. Hum. Genet. 2003)
    112. Dietary factors and the occurrence of truncating APC mutations in sporadic colon carcinomas: a Dutch population-based study. (PubMed id 12584179)1, 4 Diergaarde B....Kampman E. (Carcinogenesis 2003)
    113. Elevated serum triiodothyronine (t3) in Ashkenazi Jewish prostate cancer patients carrying the I1307k allele of the APC (adenopolyposis coli) gene. (PubMed id 12856637)1, 4 Lehrer S....Kornreich R. (Urol. Oncol. 2003)
    114. Characterization of functional domains of human EB1 family proteins. (PubMed id 14514668)1, 2 Bu W. and Su L.-K. (J. Biol. Chem. 2003)
    115. A single nucleotide primer extension assay to detect the APC I1307K gene variant. (PubMed id 14573780)1, 4 Murphy K.M....Berg K.D. (J Mol Diagn 2003)
    116. The I1307K adenomatous polyposis coli gene variant does not contribute in the assessment of the risk for colorectal cancer in Ashkenazi Jews. (PubMed id 14578136)1, 4 Strul H....Arber N. (amp 2003)
    117. Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas. (PubMed id 12907646)1, 4 Leslie A....Steele R.J. (Cancer Res. 2003)
    118. Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis. (PubMed id 12057910)1, 4 Groves C....Tomlinson I. (Am. J. Pathol. 2002)
    119. Clinical and screening implications of the I1307K adenomatous polyposis coli gene variant in Israeli Ashkenazi Jews with familial colorectal neoplasia. Evidence for a founder effect. (PubMed id 12173321)1, 4 Rozen P....Orr-Urtreger A. (Cancer 2002)
    120. Nontruncating APC germ-line mutations and mismatch repair deficiency play a minor role in APC mutation-negative polyposis. (PubMed id 11606402)1, 4 Heinimann K....Dobbie Z. (Cancer Res. 2001)
    121. Phenotypic characteristics of colo-rectal cancer in I1307K APC germline mutation carriers compared with sporadic cases. (PubMed id 11720476)1, 4 Figer A....Friedman E. (Br. J. Cancer 2001)
    122. The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the generality of U.S. population data. (PubMed id 11466700)1, 4 Bahar A.Y....Buckley M.F. (Cancer 2001)
    123. Carrier rate of APC I1307K is not increased in inflammatory bowel disease patients of Ashkenazi Jewish origin. (PubMed id 11354631)1, 4 Silverberg M.S....Siminovitch K.A. (Hum. Genet. 2001)
    124. Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex. (PubMed id 11707392)1, 2 Eklof Spink K.... Weis W.I. (EMBO J. 2001)
    125. Predictive genetic testing in children and adults: a study of emotional impact. (PubMed id 11483640)1, 4 Michie S....Marteau T.M. (J. Med. Genet. 2001)
    126. A molecular variant of the APC gene at codon 1822: its association with diet, lifestyle, and risk of colon cancer. (PubMed id 11221825)1, 4 Slattery M.L....Potter J.D. (Cancer Res. 2001)
    127. Polymorphisms and colorectal tumor risk. (PubMed id 11487538)1, 4 Houlston R.S. and Tomlinson I.P. (Gastroenterology 2001)
    128. Structural basis of the axin-adenomatous polyposis coli interaction. (PubMed id 10811618)1, 2 Spink K.E.... Weis W.I. (EMBO J. 2000)
    129. APC mutations in sporadic medulloblastomas. (PubMed id 10666372)1, 2 Huang H.... Ohgaki H. (Am. J. Pathol. 2000)
    130. Asef, a link between the tumor suppressor APC and G-protein signaling. (PubMed id 10947987)1, 2 Kawasaki Y.... Akiyama T. (Science 2000)
    131. Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor. (PubMed id 10926498)1, 2 Day C.L. and Alber T. (J. Mol. Biol. 2000)
    132. Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition. (PubMed id 9950360)1, 2 Wallis Y.L.... Macdonald F. (J. Med. Genet. 1999)
    133. The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis. (PubMed id 10470088)1, 2 Lamlum H....Tomlinson I.P.M. (Nat. Med. 1999)
    134. The APC I1307K allele and breast cancer risk. (PubMed id 9731522)1, 2 Redston M.... Offit K. (Nat. Genet. 1998)
    135. The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews. (PubMed id 9731533)1, 2 Woodage T.... Brody L.C. (Nat. Genet. 1998)
    136. Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis. (PubMed id 8990002)1, 2 van der Luijt R.B.... Fodde R. (Hum. Mutat. 1997)
    137. Drastic genetic instability of tumors and normal tissues in Turcot syndrome. (PubMed id 9419979)1, 2 Miyaki M.... Utsunomiya J. (Oncogene 1997)
    138. The molecular basis of Turcot's syndrome. (PubMed id 7661930)1, 2 Hamilton S.R.... Kinzler K.W. (N. Engl. J. Med. 1995)
    139. Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene. (PubMed id 7833149)1, 2 Dobbie Z.... Scott R.J. (Eur. J. Cancer 1994)
    140. Four novel mutations of the APC (adenomatous polyposis coli) gene in FAP patients. (PubMed id 7833931)1, 2 Stella A.... Guanti G. (Hum. Mol. Genet. 1994)
    141. Association of the APC tumor suppressor protein with catenins. (PubMed id 8259519)1, 2 Su L.-K.... Kinzler K.W. (Science 1993)
    142. Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients. (PubMed id 1338764)1, 2 Nagase H.... Nakamura Y. (Hum. Mutat. 1992)
    143. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. (PubMed id 1338904)1, 2 Miyoshi Y.... Nakamura Y. (Hum. Mol. Genet. 1992)
    144. Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma. (PubMed id 1338691)1, 2 Nakatsuru S.... Horii A. (Hum. Mol. Genet. 1992)
    145. Identification of deletion mutations and three new genes at the familial polyposis locus. (PubMed id 1678319)1, 2 Joslyn G.... White R. (Cell 1991)
    146. APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. (PubMed id 15326380)1, 9 Arnold C.N....Boland C.R. (amp 2004)
    147. Nuclear APC. (PubMed id 19928349)1, 9 Neufeld K.L. (Adv. Exp. Med. Biol. 2009)
    148. The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. (PubMed id 16188939)1, 9 Penman G.A....NAothke I.S. (J. Cell. Sci. 2005)
    149. Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours. (PubMed id 18854359)1, 9 Kohler E.M....Schneikert J. (Hum. Mol. Genet. 2009)
    150. Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations. (PubMed id 18977219)1, 9 Segditsas S....Tomlinson I.P. (Exp. Mol. Pathol. 2008)
    151. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. (PubMed id 11166179)1, 9 Zumbrunn J....NAothke I.S. (Curr. Biol. 2001)
    152. MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events. (PubMed id 19164452)1, 9 de Vogel S....van Engeland M. (Ann. Oncol. 2009)
    153. Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. (PubMed id 18160396)1, 9 Brocardo M....Henderson B.R. (J. Biol. Chem. 2008)
    154. Genetic and epigenetic alterations of the APC gene in malignant melanoma. (PubMed id 15133491)1, 9 Worm J....Guldberg P. (Oncogene 2004)
    155. Isoforms of the APC tumor suppressor and their ability to inhibit cell growth and tumorigenicity. (PubMed id 15273719)1, 9 Carson D.J....Groden J. (Oncogene 2004)
    156. Mutation analysis of APC gene in gastric cancer with microsatellite instability. (PubMed id 12378616)1, 9 Fang D.C....Fang L. (World J. Gastroenterol. 2002)
    157. Frequent promoter hypermethylation of the APC and RASSF1A tumour suppressors in parathyroid tumours. (PubMed id 20208994)1, 9 Juhlin C.C....Larsson C. (PLoS ONE 2010)
    158. Aberrant beta-catenin expression and adenomatous polyposis coli gene mutation in ameloblastoma and odontogenic carcinoma. (PubMed id 18486530)1, 9 Siriwardena B.S....Takata T. (Oral Oncol. 2009)
    159. The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. (PubMed id 18474248)1, 9 Qian J....Groden J. (Gastroenterology 2008)
    160. Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype. (PubMed id 18841156)1, 9 Van der Auwera I....Dirix L.Y. (Br. J. Cancer 2008)
    161. Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients. (PubMed id 17704924)1, 9 Jeon C.H....Park J.W. (Int J Colorectal Dis 2008)
    162. Status of reduced expression and hypermethylation of the APC tumor suppressor gene in human oral squamous cell carcinoma. (PubMed id 15754020)1, 9 Uesugi H....Tanzawa H. (Int. J. Mol. Med. 2005)
    163. The APC tumor suppressor promotes transcription-independent apoptosis in vitro. (PubMed id 15755874)1, 9 Steigerwald K....Groden J. (Mol. Cancer Res. 2005)
    164. APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. (PubMed id 17570218)1, 9 Abal M....Robine S. (Gastroenterology 2007)
    165. [Effect of Hydralazine on demethylation status and expression of APC gene, proliferation and apoptosis of human cervical cancer cell lines]. (PubMed id 18070451)1, 9 Song Y.H. and Zhang C.J. (Zhonghua Bing Li Xue Za Zhi 2007)
    166. Congenital hypertrophy of the retinal pigment epithelium and APC mutations in Chinese with familial adenomatous polyposis. (PubMed id 11741105)1, 9 Pang C.P....Lam D.S. (Ophthalmologica 2001)
    167. Association of APC gene mutations and histological characteristics of colorectal adenomas. (PubMed id 8012980)4, 9 De Benedetti L....Picasso M. (Cancer Res. 1994)
    168. Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. (PubMed id 18384130)1, 9 Castiglia D....D'Atri S. (amp 2008)
    169. Loss of heterozygosity of the APC gene in oral squamous cell carcinoma. (PubMed id 18617334)1, 9 Rivero E.R....Nunes F.D. (Pathol. Res. Pract. 2008)
    170. [Detection and significance of APC gene promoter hypermethylation in serum of breast cancer patients]. (PubMed id 17222366)1, 9 Zhang J.J....Deng G.R. (Ai Zheng 2007)
    171. Promoter methylation profile in gallbladder cancer. (PubMed id 16699861)1, 9 Roa J.C....Schneider B. (J. Gastroenterol. 2006)
    172. Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma. (PubMed id 16163548)1, 9 Iwai S....Yura Y. (J. Cancer Res. Clin. Oncol. 2005)
    173. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. (PubMed id 11533658)1, 9 Ryo A....Lu K.P. (Nat. Cell Biol. 2001)
    174. [Gardner fibroma: case report and discussion of a new soft tissue tumor entity]. (PubMed id 20063100)1, 9 Lanckohr C....Kuhnen C. (Pathologe 2010)
    175. Prognostic and therapeutic implications of Apc mutations in colorectal cancer. (PubMed id 19110823)1, 9 Quyn A.J....NAothke I.S. (Surgeon 2008)
    176. Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases. (PubMed id 18807072)1, 9 Gaumann A....Hartmann A. (Virchows Arch. 2008)
    177. [Abnormalities of chromosome 8, APC and beta-catenin genes in aggressive fibromatosis]. (PubMed id 18646694)1, 9 Yang J.L....Zhu X.Z. (Zhonghua Zhong Liu Za Zhi 2008)
    178. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. (PubMed id 16763565)1, 9 Draviam V.M....Sorger P.K. (EMBO J. 2006)
    179. Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. (PubMed id 15331612)1, 9 Li Q. and Dashwood R.H. (J. Biol. Chem. 2004)
    180. The APC/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: a mutational analysis. (PubMed id 11920497)1, 9 Aust D.E....Waldman F.M. (Cancer 2002)
    181. Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome. (PubMed id 12388762)1, 9 Askham J.M.... Morrison E.E. (Mol. Biol. Cell 2002)
    182. The interaction between beta-catenin, GSK3beta and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer. (PubMed id 11251183)1, 9 Davies G....Mason M.D. (Int. J. Oncol. 2001)
    183. The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. (PubMed id 10951583)1, 9 Erdmann K.S....Heumann R. (Oncogene 2000)
    184. Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation. (PubMed id 8074697)1, 9 Shibata T....Hirohashi S. (Biochem. Biophys. Res. Commun. 1994)
    185. APC gene mutations in Chinese familial adenomatous polyposis patients. (PubMed id 20333795)1, 9 Sheng J.Q....Li S.R. (World J. Gastroenterol. 2010)
    186. Different phenotype manifestation of familial adenomatous polyposis in families with APC mutation at codon 1309. (PubMed id 19728755)1, 9 Wachsmannova-Matelova L....Zajac V. (Neoplasma 2009)
    187. Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor). (PubMed id 19124205)1, 9 Ferenc T....Sygut J. (Pathol. Res. Pract. 2009)
    188. A large novel deletion in the APC promoter region causes gene silencing and leads to classical familial adenomatous polyposis in a Manitoba Mennonite kindred. (PubMed id 18982352)1, 9 Charames G.S....Bapat B. (Hum. Genet. 2008)
    189. Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP). (PubMed id 17486639)1, 9 Aretz S....Friedl W. (Hum. Mutat. 2007)
    190. High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients. (PubMed id 17947477)1, 9 Henrique R....JerA^nimo C. (Clin. Cancer Res. 2007)
    191. APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer. (PubMed id 16981189)1, 9 Iacopetta B....Kawakami K. (Int. J. Cancer 2006)
    192. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. (PubMed id 16510874)1, 9 Sierra J....Jones K.A. (amp 2006)
    193. Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus. (PubMed id 16407829)1, 9 ClAcment G....Benhattar J. (Oncogene 2006)
    194. Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum. (PubMed id 16142311)1, 9 Kim D.H....Kim Y.S. (Int. J. Oncol. 2005)
    195. Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1. (PubMed id 15981102)1, 9 Sun C....Horii A. (J. Neurooncol. 2005)
    196. Prognostic DNA methylation marker in serum of cancer patients. (PubMed id 15251938)1, 9 MA1ller H.M....Widschwendter M. (Ann. N. Y. Acad. Sci. 2004)
    197. N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. (PubMed id 14728717)1, 9 Jaiswal A.S....Narayan S. (Mol. Cancer 2004)
    198. Germline APC mutation on the beta-catenin binding site is associated with a decreased apoptotic level in colorectal adenomas. (PubMed id 12527714)4, 9 Venesio T....Risio M. (Mod. Pathol. 2003)
    199. Genetic and protein markers related to in situ growth and multiplicity in small sporadic colorectal adenomas. (PubMed id 12737446)1, 9 LA...Rognum T.O. (Scand. J. Gastroenterol. 2003)
    200. Abnormalities of the APC/beta-catenin pathway in endometrial cancer. (PubMed id 12439748)1, 9 Moreno-Bueno G....Palacios J. (Oncogene 2002)
    201. Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma. (PubMed id 12163385)1, 9 Lee J.H....Wu T.T. (Am. J. Pathol. 2002)
    202. APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers. (PubMed id 11921277)1, 9 Gerstein A.V....Papadopoulos N. (amp 2002)
    203. Loss of heterozygosity and protein expression of APC gene in renal cell carcinomas. (PubMed id 10426194)1, 9 PeA8ina-Slaus N....PaveliA8 J. (J. Mol. Med. 1999)
    204. APC gene mutations and allelic losses in sporadic ampullary tumours: evidence of genetic difference from tumours associated with familial adenomatous polyposis. (PubMed id 8903471)4, 9 Achille A....Scarpa A. (Int. J. Cancer 1996)
    205. APC binds to the novel protein EB1. (PubMed id 7606712)1, 9 Su L.-K.... Kinzler K.W. (Cancer Res. 1995)
    206. Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. (PubMed id 20092957)1, 9 VladusiA8 T....FranekiA8 ColiA8 J. (Pathol. Res. Pract. 2010)
    207. A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk. (PubMed id 19515250)1, 9 Howarth K....Tomlinson I. (BMC Med. Genet. 2009)
    208. Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer. (PubMed id 19773381)1, 9 Lee B.B....Kim D.H. (Clin. Cancer Res. 2009)
    209. Report of a family segregating mutations in both the APC and MSH2 genes: juvenile onset of colorectal cancer in a double heterozygote. (PubMed id 18629513)1, 9 Uhrhammer N. and Bignon Y.J. (Int J Colorectal Dis 2008)
    210. DNA methylation markers and early recurrence in stage I lung cancer. (PubMed id 18337602)1, 9 Brock M.V....Herman J.G. (N. Engl. J. Med. 2008)
    211. DNA methylation in benign breast epithelium in relation to age and breast cancer risk. (PubMed id 18483325)1, 9 Euhus D.M....Lewis C.M. (amp 2008)
    212. Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age 72. (PubMed id 19036155)1, 9 Nilbert M....Mangell P. (BMC Med. Genet. 2008)
    213. Alternative splicing and nonsense-mediated mRNA decay in the regulation of a new adenomatous polyposis coli transcript. (PubMed id 17360132)1, 9 De Rosa M....Izzo P. (Gene 2007)
    214. Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies. (PubMed id 17039269)1, 9 Green R.C....Younghusband H.B. (Fam. Cancer 2007)
    215. No difference in the occurrence of mismatch repair defects and APC and CTNNB1 genes mutation in a multi-racial colorectal carcinoma patient cohort. (PubMed id 17454753)1, 9 Tan L.P....Peh S.C. (Pathology 2007)
    216. A novel frameshift mutation in the APC gene at exon 15 in familial adenomatous polyposis (FAP) with desmoid tumour. (PubMed id 17506007)1, 9 Ekwueme K.C....Rooney P.S. (Scand. J. Gastroenterol. 2007)
    217. Exclusion of APC and VHL gene deletions by array-based comparative hybridization in two patients with microscopically visible chromosomal aberrations. (PubMed id 17954272)1, 9 Wallerstein R.J....Toruner G.A. (Cancer Genet. Cytogenet. 2007)
    218. Constitutional high expression of an APC mRNA isoform in a subset of attenuated familial adenomatous polyposis patients. (PubMed id 17143620)1, 9 Venesio T....Risio M. (J. Mol. Med. 2007)
    219. Multiple gynecologic tumors as rare associated phenotypes of FAP/Gardner syndrome in a family with the novel germline mutation in the APC gene. (PubMed id 16433700)1, 9 Kovac M....Zajac V. (Clin. Genet. 2006)
    220. Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy. (PubMed id 16322291)1, 9 Rosenbaum E....Sidransky D. (Clin. Cancer Res. 2005)
    221. Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate. (PubMed id 15548520)1, 9 Narayan S....Balusu R. (J. Biol. Chem. 2005)
    222. Identification and in vivo role of the Armadillo-Legless interaction. (PubMed id 15294866)1, 9 Hoffmans R. and Basler K. (Development 2004)
    223. Maternal mosaicism for a second mutational event--a novel deletion--in a familial adenomatous polyposis family harboring a new germ-line mutation in the alternatively spliced-exon 9 region of APC. (PubMed id 11754114)1, 9 Davidson S....Amikam D. (Hum. Mutat. 2002)
    224. Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. (PubMed id 11487578)1, 9 Rubinfeld B....Polakis P. (J. Biol. Chem. 2001)
    225. Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. (PubMed id 11751382)1, 9 Zhang T....Boman B.M. (Cancer Res. 2001)
    226. Expression and interaction of different catenins in colorectal carcinoma cells. (PubMed id 11712088)1, 9 KucerovA! D....SovovA! V. (Int. J. Mol. Med. 2001)
    227. Hot spots in beta-catenin for interactions with LEF-1, conductin and APC. (PubMed id 10966653)1, 9 von Kries J.P.... Birchmeier W. (Nat. Struct. Biol. 2000)
    228. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. (PubMed id 8638126)1, 9 Rubinfeld B....Polakis P. (Science 1996)
    229. Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444. (PubMed id 7795585)4, 9 Caspari R....Thomas G. (Hum. Mol. Genet. 1995)
    230. Loss of heterozygosity on chromosome 5 in sporadic ovarian carcinoma is a late event and is not associated with mutations in APC at 5q21-22. (PubMed id 8019564)4, 9 Allan G.J....Foulkes W.D. (Hum. Mutat. 1994)
    231. Association between wild type and mutant APC gene products. (PubMed id 8389242)1, 9 Su L.K....Kinzler K.W. (Cancer Res. 1993)
    232. APC binds intermediate filaments and is required for their reorganization during cell migration. (PubMed id 23382461)1 Sakamoto Y....Etienne-Manneville S. (J. Cell Biol. 2013)
    233. Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex. (PubMed id 23469016)1 Pe'er T....Tzur A. (PLoS ONE 2013)
    234. APC/I^-catenin-rich complexes at membrane protrusions regulate mammary tumor cell migration and mesenchymal morphology. (PubMed id 23302090)1 Odenwald M.A....Goss K.H. (BMC Cancer 2013)
    235. Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/I^-catenin signalling thresholds for tumourigenesis. (PubMed id 23085758)1 Christie M....Sieber O.M. (Oncogene 2013)
    236. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    237. Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation. (PubMed id 23840886)1 Schneikert J....Behrens J. (PLoS ONE 2013)
    238. Adenomatous polyposis coli-mediated accumulation of abasic DNA lesions lead to cigarette smoke condensate-induced neoplastic transformation of normal breast epithelial cells. (PubMed id 23555190)1 Jaiswal A.S....Narayan S. (Neoplasia 2013)
    239. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. (PubMed id 23788249)1 Green R.C....Biesecker L.G. (Genet. Med. 2013)
    240. Clinical and molecular features of attenuated adenomatous polyposis in northern Italy. (PubMed id 22976915)1 de Leon M.P....Venesio T. (Tech Coloproctol 2013)
    241. Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling. (PubMed id 23646120)1 Li A....Minoo P. (PLoS ONE 2013)
    242. Common genetic variants in Wnt signaling pathway genes as potential prognostic biomarkers for colorectal cancer. (PubMed id 23405266)1 Ting W.C....Bao B.Y. (PLoS ONE 2013)
    243. Novel mutations of the APC gene and genetic consequences of splicing mutations in the Czech FAP families. (PubMed id 22987206)1 SchwarzovA! L....KohoutovA! M. (Fam. Cancer 2013)
    244. miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma. (PubMed id 23087084)1 Shen G....Chen D. (Carcinogenesis 2013)
    245. HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction. (PubMed id 23277359)1 Tran H....Polakis P. (J. Biol. Chem. 2013)
    246. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    247. The APC p.I1307K polymorphism is a significant risk factor for CRC in average risk Ashkenazi Jews. (PubMed id 23896379)1 Boursi B....Kraus S. (Eur. J. Cancer 2013)
    248. Desmoid tumour biology in patients with familial adenomatous polyposis coli. (PubMed id 23334997)1 Schiessling S....Kadmon M. (Br J Surg 2013)
    249. Novel insertion mutation p.Asp610GlyfsX23 in APC gene causes familial adenomatous polyposis in Chinese families. (PubMed id 23291410)1 Song G....Yang N. (Gene 2013)
    250. Comparison study of MS-HRM and pyrosequencing techniques for quantification of APC and CDKN2A gene methylation. (PubMed id 23326336)1 Migheli F....Migliore L. (PLoS ONE 2013)
    251. A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions. (PubMed id 23871111)1 Asanov A....Vaca L. (Cell Calcium 2013)
    252. Methylation of APC and GSTP1 in non-neoplastic tissue adjacent to prostate tumour and mortality from prostate cancer. (PubMed id 23874531)1 Richiardi L....Merletti F. (PLoS ONE 2013)
    253. A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma. (PubMed id 22907428)1 Yang Y....Wang H. (Oncogene 2013)
    254. APC gene hypermethylation and prostate cancer: a systematic review and meta-analysis. (PubMed id 23299921)1 Chen Y....Hu Y. (Eur. J. Hum. Genet. 2013)
    255. Adenomatous polyposis coli gene involvement in ileal enterochromaffin cell neuroendocrine neoplasms. (PubMed id 24139208)1 Bottarelli L....Rindi G. (Hum. Pathol. 2013)
    256. CTNNB1, AXIN1 and APC expression analysis of different medulloblastoma variants. (PubMed id 23525311)1 Silva R.d....Oba-Shinjo S.M. (Clinics (Sao Paulo) 2013)
    257. Detailed molecular genetics of the APC*E1317Q mutation in tumor tissue suggest it may not be pathologically significant. (PubMed id 23846443)1 Zauber P....Sabbath-Solitare M. (Diagn. Mol. Pathol. 2013)
    258. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    259. Analysis of the methylation patterns of the p16 INK4A, p15 INK4B, and APC genes in gastric adenocarcinoma patients from a Brazilian population. (PubMed id 23504555)1 do Nascimento Borges B....Harada M.L. (Tumour Biol. 2013)
    260. Mutational spectrum of the APC and MUTYH genes and genotype-phenotype correlations in Brazilian FAP, AFAP, and MAP patients. (PubMed id 23561487)1 Torrezan G.T....Carraro D.M. (Orphanet J Rare Dis 2013)
    261. Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells. (PubMed id 23393221)1 Olsen A.K....Troelsen J.T. (Carcinogenesis 2013)
    262. Upregulated miR-155 in papillary thyroid carcinoma promotes tumor growth by targeting APC and activating Wnt/I^-catenin signaling. (PubMed id 23796566)1 Zhang X....Lv Z. (J. Clin. Endocrinol. Metab. 2013)
    263. APC germline mutations in individuals being evaluated for familial adenomatous polyposis: a review of the Mayo Clinic experience with 1591 consecutive tests. (PubMed id 23159591)1 Kerr S.E....Halling K.C. (J Mol Diagn 2013)
    264. A clinical-biological risk stratification model for resected gastric cancer: prognostic impact of Her2, Fhit, and APC expression status. (PubMed id 23131390)1 Bria E....Scarpa A. (Ann. Oncol. 2013)
    265. A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains. (PubMed id 22434720)1 Sotelo N.S....Pulido R. (J. Cell. Biochem. 2012)
    266. Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. (PubMed id 22898821)1 Pfister A.S....Behrens J. (J. Biol. Chem. 2012)
    267. Regulation of the metabolite profile by an APC gene mutation in colorectal cancer. (PubMed id 22380946)1 Yoshie T....Yoshida M. (Cancer Sci. 2012)
    268. Loss of adenomatous poliposis coli-I+3 integrin interaction promotes endothelial apoptosis in mice and humans. (PubMed id 23011394)1 de Jesus Perez V.A....Rabinovitch M. (Circ. Res. 2012)
    269. Wnt signaling through inhibition of I^-catenin degradation in an intact Axin1 complex. (PubMed id 22682247)1 Li V.S....Clevers H. (Cell 2012)
    270. Structural basis for the recognition of Asef by adenomatous polyposis coli. (PubMed id 21788986)1 Zhang Z....Wu G. (Cell Res. 2012)
    271. APC gene deletions in gastric adenocarcinomas in a Chinese population: a correlation with tumour progression. (PubMed id 22262720)1 Fang Z....Wan J. (amp 2012)
    272. Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning. (PubMed id 22128170)2 Pfister A.S.... Behrens J. (J. Biol. Chem. 2012)
    273. Genetic variations in stem cell-related genes and colorectal cancer prognosis. (PubMed id 22528324)1 Yang H....Xing J. (J Gastrointest Cancer 2012)
    274. Genetic alterations in members of the Wnt pathway in acute leukemia. (PubMed id 21902576)1 Erbilgin Y....Sayitoglu M. (amp 2012)
    275. Association of APC and REEP5 gene polymorphisms with major depression disorder and treatment response to antidepressants in a Han Chinese population. (PubMed id 22795047)1 Yang Z....Li T. (Gen Hosp Psychiatry 2012)
    276. Evaluation of GSTP1 and APC methylation as indicators for repeat biopsy in a high-risk cohort of men with negative initial prostate biopsies. (PubMed id 22077694)1 Trock B.J....Partin A.W. (BJU Int. 2012)
    277. Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. (PubMed id 22277732)1 Ladd J.J....Hanash S.M. (Cancer Prev Res (Phila) 2012)
    278. CTNNB1 genotyping and APC screening in pediatric desmoid tumors: a proposed algorithm. (PubMed id 22372443)1 Wang W.L....LA^pez-Terrada D. (Pediatr. Dev. Pathol. 2012)
    279. DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients. (PubMed id 22324744)1 Xu X.M....Cai J.P. (Eur. J. Clin. Invest. 2012)
    280. Epiretinal membrane and retinal pigment epithelial lesions in a young child and detection of de novo APC mutation. (PubMed id 22893084)1 Ganesh A....Shields C.L. (Arch. Ophthalmol. 2012)
    281. Epithelial to mesenchymal transition (EMT) biomarkers--E-cadherin, beta-catenin, APC and Vimentin--in oral squamous cell carcinogenesis and transformation. (PubMed id 22704062)1 Chaw S.Y....Farah C.S. (Oral Oncol. 2012)
    282. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    283. The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin. (PubMed id 22719865)1 Dikovskaya D....NAothke I.S. (PLoS ONE 2012)
    284. APC and Smad7 link TGFI^ type I receptors to the microtubule system to promote cell migration. (PubMed id 22496417)1 Ekman M....LandstrAPm M. (Mol. Biol. Cell 2012)
    285. Hypermethylation of adenomatous polyposis coli gene promoter is associated with novel Wnt signaling pathway in gastric adenomas. (PubMed id 22741528)1 Wang Z.K....Zhang X.H. (J. Gastroenterol. Hepatol. 2012)
    286. Colon cancer prevention by detection of APC gene mutation in a family with attenuated familial adenomatous polyposis. (PubMed id 23244118)1 Poovorawan K....Poovorawan Y. (Asian Pac. J. Cancer Prev. 2012)
    287. Prevalence and phenotypes of APC and MUTYH mutations in patients with multiple colorectal adenomas. (PubMed id 22851115)1 Grover S....Syngal S. (JAMA 2012)
    288. Deep intronic APC mutations explain a substantial proportion of patients with familial or early-onset adenomatous polyposis. (PubMed id 22431159)1 Spier I....Aretz S. (Hum. Mutat. 2012)
    289. Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the I^-catenin destruction complex. (PubMed id 22761442)1 Tran H. and Polakis P. (J. Biol. Chem. 2012)
    290. Association study of APC polymorphisms with colorectal cancer in Han Chinese. (PubMed id 22796397)1 Huang X....He G. (Clin. Biochem. 2012)
    291. Increased variance in germline allele-specific expression of APC associates with colorectal cancer. (PubMed id 21995949)1 Curia M.C....Cama A. (Gastroenterology 2012)
    292. Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4. (PubMed id 22740476)1 Lim J.W....Simpson R.J. (Electrophoresis 2012)
    293. Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function. (PubMed id 22787431)1 Jaiswal A.S....Narayan S. (Neoplasia 2012)
    294. Copy number variation of the APC gene is associated with regulation of bone mineral density. (PubMed id 22884971)1 Chew S....Wilson S.G. (Bone 2012)
    295. In vitro stability of APC gene sequences and the influence of DNA repair status. (PubMed id 22294772)1 Turnbull C.L....Farrington S.M. (Mutagenesis 2012)
    296. Missense mutations in MLH1, MSH2, KRAS, and APC genes in colorectal cancer patients in Malaysia. (PubMed id 22669205)1 Abdul Murad N.A....Jamal R. (Dig. Dis. Sci. 2012)
    297. Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity. (PubMed id 22184111)1 Valvezan A.J....Klein P.S. (J. Biol. Chem. 2012)
    298. Identification of a Wnt-induced protein complex by affinity proteomics using an antibody that recognizes a sub-population of I^-catenin. (PubMed id 22469663)1 Layton M.J....Simpson R.J. (Biochim. Biophys. Acta 2012)
    299. [Expression of Wnt5a, APC, I^-catenin and their clinical significance in human colorectal adenocarcinoma]. (PubMed id 23159080)1 Cao Y.C....Geng M. (Zhonghua Zhong Liu Za Zhi 2012)
    300. Perinatal detection of familial adenomatous polyposis. (PubMed id 22825279)1 Birsner M.L....Hueppchen N.A. (Obstet Gynecol 2012)
    301. Aberrant promoter methylation of the RASSF1A and APC genes in epithelial ovarian carcinoma development. (PubMed id 23055343)1 Bhagat R....Krishnamoorthy L. (Cell Oncol (Dordr) 2012)
    302. A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation. (PubMed id 22509309)1 Chandra S.H....Schneikert J. (PLoS ONE 2012)
    303. AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene. (PubMed id 21484796)1 Mimura M....Yoshida M. (Int. J. Cancer 2012)
    304. Multiple jejunal cancers resulting from combination of germline APC and MLH1 mutations. (PubMed id 22886683)1 Lindor N.M....Thibodeau S.N. (Fam. Cancer 2012)
    305. Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study. (PubMed id 22864938)1 Gay L.J....Arends M.J. (J. Pathol. 2012)
    306. Family history, surgery, and APC mutation are risk factors for desmoid tumors in familial adenomatous polyposis: an international cohort study. (PubMed id 21904137)1 Nieuwenhuis M.H....Vasen H.F. (Dis. Colon Rectum 2011)
    307. Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? (PubMed id 21859464)1 Minde D.P....Maurice M.M. (Mol. Cancer 2011)
    308. Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. (PubMed id 21664290)1 Brocardo M.G....Henderson B.R. (amp 2011)
    309. Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. (PubMed id 21311754)1 Sudhaharan T....Ahmed S. (PLoS ONE 2011)
    310. Association of tissue promoter methylation levels of APC, TGFI^2, HOXD3 and RASSF1A with prostate cancer progression. (PubMed id 21207416)1 Liu L....Bapat B. (Int. J. Cancer 2011)
    311. Detection of APC gene deletions in colorectal malignancies using quantitative PCR in a Chinese population. (PubMed id 21359685)1 Fang Z....Wan J. (Pathol. Oncol. Res. 2011)
    312. A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Tunisian family with FAP. (PubMed id 21598003)1 Miladi-Abdennadher I....Mokdad-Gargouri R. (Fam. Cancer 2011)
    313. Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma. (PubMed id 22073196)1 Jain S....Su Y.H. (PLoS ONE 2011)
    314. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    315. Mutation analysis of the APC gene in unrelated Korean patients with FAP: four novel mutations with unusual phenotype. (PubMed id 21110124)1 Han S.H....Lee K.R. (Fam. Cancer 2011)
    316. Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis. (PubMed id 21573497)1 Luo F....Arends M.J. (Oncol. Rep. 2011)
    317. EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1. (PubMed id 21538028)1 Geddert H....Sarbia M. (Cell Oncol (Dordr) 2011)
    318. Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein. (PubMed id 21858148)1 Zhang Z....Wu G. (PLoS ONE 2011)
    319. Molecular genetics of supernumerary tooth formation. (PubMed id 21309064)1 Wang X.P. and Fan J. (Genesis 2011)
    320. APC and KRAS mutations in distal colorectal polyps are related to smoking habits in men: results of a cross-sectional study. (PubMed id 21865138)1 MartA-nez F....DasA- F. (amp 2011)
    321. Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population. (PubMed id 21807601)1 Syed Sameer A....Siddiqi M.A. (Hum. Genomics 2011)
    322. Activation of beta-catenin is a late event in the pathogenesis of nephroblastomas and rarely correlated with genetic changes of the APC gene. (PubMed id 22081130)1 Grill C....Guertl B. (Pathology 2011)
    323. Association of APC and MCC polymorphisms with increased breast cancer risk in an Indian population. (PubMed id 21279955)1 Mukherjee N....Panda C.K. (Int. J. Biol. Markers 2011)
    324. Clinical and genetic characterization of classical forms of familial adenomatous polyposis: a Spanish population study. (PubMed id 20924072)1 Rivera B....Urioste M. (Ann. Oncol. 2011)
    325. Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis. (PubMed id 21643010)1 Rohlin A....Nordling M. (Oncogene 2011)
    326. The genetics of familial adenomatous polyposis (FAP) and MutYH-associated polyposis (MAP). (PubMed id 22103048)1 Claes K....Kartheuser A. (Acta Gastroenterol. Belg. 2011)
    327. Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling. (PubMed id 21949247)1 Scholer-Dahirel A....McLaughlin M.E. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    328. Role of heterozygous APC mutation in niche succession and initiation of colorectal cancer--a computational study. (PubMed id 21857949)1 Sasikumar R....Manoj M. (PLoS ONE 2011)
    329. Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/I^-catenin signaling. (PubMed id 20971552)1 Hsieh A....Jung G. (Cancer Lett. 2011)
    330. Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68. (PubMed id 22000517)1 Morishita E.C....Yokoyama S. (Structure 2011)
    331. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    332. Brain metastases exhibit gross deletions of the APC gene. (PubMed id 21442240)1 PeA8ina-A laus N....Bulat S. (Brain Tumor Pathol 2011)
    333. Germinoma presenting as a fourth cranial nerve palsy in a patient with adenomatous polyposis coli (APC) gene mutation. (PubMed id 21315632)1 Lima B.R....Rychwalski P.J. (J AAPOS 2011)
    334. [Expression of DNA methylation of APC in peripheral blood and tumor tissue in patients with esophageal squamous cell carcinoma]. (PubMed id 21948542)1 WANG C.C....LING Z.Q. (Zhonghua Wei Chang Wai Ke Za Zhi 2011)
    335. Analysis of the adenomatous polyposis coli (APC) gene in childhood and adolescent germ cell tumors. (PubMed id 21225915)1 Okpanyi V....SchAPnberger S. (amp 2011)
    336. Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1). (PubMed id 21498506)2 Tanneberger K....Behrens J. (J. Biol. Chem. 2011)
    337. APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC. (PubMed id 21665989)1 Schneikert J....Behrens J. (Hum. Mol. Genet. 2011)
    338. A survey of APC mutations in Quebec. (PubMed id 21779980)1 Jarry J....Chong G. (Fam. Cancer 2011)
    339. Adenomatous polyposis coli regulates axon arborization and cytoskeleton organization via its N-terminus. (PubMed id 21915313)1 Chen Y....Snider W.D. (PLoS ONE 2011)
    340. Readthrough of premature termination codons in the adenomatous polyposis coli gene restores its biological activity in human cancer cells. (PubMed id 21909382)1 Floquet C....Bidou L. (PLoS ONE 2011)
    341. Molecular genetic analysis of 103 sporadic colorectal tumours in Czech patients. (PubMed id 21901162)1 Vasovcak P....Krepelova A. (PLoS ONE 2011)
    342. Aberrant methylation of RARbeta2 and APC genes in voided urine as molecular markers for early detection of bilharzial and nonbilharzial bladder cancer. (PubMed id 21680534)1 Eissa S....El-Ahmady O. (amp 2011)
    343. Correlation between COX-2 and APC expression in left versus right-sided human colon cancer. (PubMed id 21737640)1 Nasir A....Coppola D. (Anticancer Res. 2011)
    344. The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium. (PubMed id 21900494)1 Marshall T.W....Rosenblatt J. (Mol. Biol. Cell 2011)
    345. Novel double-negative feedback loop between adenomatous polyposis coli and Musashi1 in colon epithelia. (PubMed id 21199875)1 Spears E. and Neufeld K.L. (J. Biol. Chem. 2011)
    346. Proteomic identification of overexpressed adenomatous polyposis coli and cyclin B3 during endoderm differentiation from human embryonic stem cells. (PubMed id 21404461)1 Lee D.H....Kim S.K. (Pancreas 2011)
    347. Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability. (PubMed id 20544848)1 Albuquerque C....Fodde R. (amp 2010)
    348. Large intron 14 rearrangement in APC results in splice defect and attenuated FAP. (PubMed id 20033212)1 Tuohy T.M....Burt R.W. (Hum. Genet. 2010)
    349. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    350. Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection. (PubMed id 20844082)1 Newton I.P....Rocha S. (Mol. Biol. Cell 2010)
    351. Methylated APC and GSTP1 genes in serum DNA correlate with the presence of circulating blood tumor cells and are associated with a more aggressive and advanced breast cancer disease. (PubMed id 20696638)1 Matuschek C....Bojar H. (Eur. J. Med. Res. 2010)
    352. DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type. (PubMed id 19945765)1 Hawes S.E....Vesselle H. (Lung Cancer 2010)
    353. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. (PubMed id 20937854)2 Zaoui K.... Badache A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    354. Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion. (PubMed id 20519433)1 Harris E.S. and Nelson W.J. (Mol. Biol. Cell 2010)
    355. Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair. (PubMed id 20658693)1 Li A....Li C. (Dev. Dyn. 2010)
    356. MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. (PubMed id 20128690)1 Sue Ng S....Clevers H. (Biol. Chem. 2010)
    357. Germline APC mutation spectrum derived from 863 genomic variations identified through a 15-year medical genetics service to French patients with FAP. (PubMed id 20685668)1 Lagarde A....Olschwang S. (J. Med. Genet. 2010)
    358. Three novel mutations of the APC gene in Korean patients with familial adenomatous polyposis. (PubMed id 20513532)1 Jang Y.H....Min W.K. (Cancer Genet. Cytogenet. 2010)
    359. Metachronous multifocal desmoid-type fibromatoses along the neuraxis with adenomatous polyposis syndrome. (PubMed id 20887112)1 Chung K.H....Owler B.K. (J Neurosurg Pediatr 2010)
    360. Mutational analysis of E-cadherin, I^-catenin and APC genes in synovial sarcomas. (PubMed id 20840677)1 Subramaniam M.M....Llombart-Bosch A. (Histopathology 2010)
    361. Allele-specific expression of APC in adenomatous polyposis families. (PubMed id 20434453)1 CastellsaguAc E....CapellA! G. (Gastroenterology 2010)
    362. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    363. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    364. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    365. [Effect of triptolide on reversing hypermethylation of apc gene in Jurkat cells and its possible mechanisms]. (PubMed id 20723290)1 Wu X.M....Fan L.P. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010)
    366. Impact of group IVA cytosolic phospholipase A2 gene polymorphisms on phenotypic features of patients with familial adenomatous polyposis. (PubMed id 19795129)4 Umeno J....Iida M. (Int J Colorectal Dis 2010)
    367. APC promoter hypermethylation is an early event in endometrial tumorigenesis. (PubMed id 19900189)1 Ignatov A....Schneider-Stock R. (Cancer Sci. 2010)
    368. Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers. (PubMed id 20978149)1 Gaujoux S....Bertherat J. (Clin. Cancer Res. 2010)
    369. PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. (PubMed id 20696900)1 Poulogiannis G....Arends M.J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    370. Gene variants associated to malignant thyroid disease in familial adenomatous polyposis: a novel APC germline mutation. (PubMed id 20935450)1 Martayan A....Stigliano V. (J. Endocrinol. Invest. 2010)
    371. Mutational spectrum of APC and genotype-phenotype correlations in Greek FAP patients. (PubMed id 20649969)1 Fostira F....Yannoukakos D. (BMC Cancer 2010)
    372. Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development. (PubMed id 21057000)1 Zhang T....Boman B.M. (Am. J. Pathol. 2010)
    373. Parafibromin and APC as screening markers for malignant potential in atypical parathyroid adenomas. (PubMed id 20473645)1 Juhlin C.C....Larsson C. (Endocr. Pathol. 2010)
    374. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    375. Location in the large bowel influences the APC mutations observed in FAP adenomas. (PubMed id 20229069)1 Will O.C....Tomlinson I.P. (Fam. Cancer 2010)
    376. The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis. (PubMed id 19900451)1 Qian J....Groden J. (Gastroenterology 2010)
    377. Aberrant WNT/I^-catenin signaling in parathyroid carcinoma. (PubMed id 21078161)1 Svedlund J....Westin G. (Mol. Cancer 2010)
    378. EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1. (PubMed id 20978327)1 Geddert H....Sarbia M. (Anal Cell Pathol (Amst) 2010)
    379. Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer. (PubMed id 20371677)1 Saito K....Minamoto T. (Clin. Cancer Res. 2010)
    380. DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. (PubMed id 20850014)1 Rai K....Jones D.A. (Cell 2010)
    381. KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC. (PubMed id 20696710)1 Jaulin F. and Kreitzer G. (J. Cell Biol. 2010)
    382. Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. (PubMed id 19966865)1 Kohler E.M....Schneikert J. (Oncogene 2010)
    383. Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain. (PubMed id 20509626)2 Kaieda S.... Ikegami T. (Biochemistry 2010)
    384. [Expressions of APC and c-Myc and its implication on non-small cell lung cancer]. (PubMed id 21302450)1 Wang S.F....Liu L.X. (Sichuan Da Xue Xue Bao Yi Xue Ban 2010)
    385. Screening for common copy-number variants in cancer genes. (PubMed id 21156252)4 Tyson J....Armour J.A. (Cancer Genet. Cytogenet. 2010)
    386. Aberrant promoter CpG island hypermethylation of the adenomatosis polyposis coli gene can serve as a good prognostic factor by affecting lymph node metastasis in squamous cell carcinoma of the esophagus. (PubMed id 18847451)1 Kim Y.T....Kim J.H. (Dis. Esophagus 2009)
    387. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    388. DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus. (PubMed id 19584833)1 Wang J.S....Canto M.I. (Am. J. Gastroenterol. 2009)
    389. RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. (PubMed id 19506903)1 Lin Q....Zhu J. (J. Cancer Res. Clin. Oncol. 2009)
    390. A gene marker panel covering the Wnt and the Ras-Raf-MEK-MAPK signalling pathways allows to detect gene mutations in 80% of early (UICC I) colon cancer stages in humans. (PubMed id 19679059)1 Scholtka B....Steinberg P. (Cancer Epidemiol 2009)
    391. [Correlation of BRCA1 and APC aberrant methylation with the response to anthracycline-based neoadjuvant chemotherapy in primary breast cancer]. (PubMed id 19615284)1 Yuan P....Li J.F. (Zhonghua Zhong Liu Za Zhi 2009)
    392. Expression and significance of adenomatous polyposis coli, beta-catenin, E-cadherin and cyclin D1 in esophageal squamous cell carcinoma assessed by tissue microarray. (PubMed id 19448414)1 Peng H....Li S.M. (Ai Zheng 2009)
    393. Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring. (PubMed id 19703905)1 Beamish H....Gabrielli B. (J. Biol. Chem. 2009)
    394. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    395. The adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis. (PubMed id 19928354)1 Benchabane H. and Ahmed Y. (Adv. Exp. Med. Biol. 2009)
    396. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    397. Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2. (PubMed id 19261806)1 Zhang J....Mao Y. (Mol. Biol. Cell 2009)
    398. Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and phosphatidylinositol 3-kinase. (PubMed id 19525225)1 Kawasaki Y....Akiyama T. (J. Biol. Chem. 2009)
    399. The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. (PubMed id 19893577)2 Kawasaki Y.... Akiyama T. (EMBO Rep. 2009)
    400. Analysis of rare APC variants at the mRNA level: six pathogenic mutations and literature review. (PubMed id 19196998)1 Kaufmann A....Aretz S. (J Mol Diagn 2009)
    401. APC proteins. Preface. (PubMed id 19928347)1 NAothke I.S. and McCartney B.M. (Adv. Exp. Med. Biol. 2009)
    402. Hypermethylation of APC promoter 1A is associated with moderate activation of Wnt signalling pathway in a subset of colorectal serrated adenomas. (PubMed id 19912361)1 Fu X....Zhang Y. (Histopathology 2009)
    403. The role of APC in mitosis and in chromosome instability. (PubMed id 19928352)1 Caldwell C.M. and Kaplan K.B. (Adv. Exp. Med. Biol. 2009)
    404. The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. (PubMed id 19576224)1 Huang X.... Dubiel W. (J. Mol. Biol. 2009)
    405. A missense mutation in the APC tumor suppressor gene disrupts an ASF/SF2 splicing enhancer motif and causes pathogenic skipping of exon 14. (PubMed id 19111562)1 GonAsalves V....Isidro G. (Mutat. Res. 2009)
    406. Adenomatous polyposis coli 1A is likely to be methylated as a passenger in human gastric carcinogenesis. (PubMed id 19527921)1 Hosoya K....Ushijima T. (Cancer Lett. 2009)
    407. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    408. Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf. (PubMed id 19378335)1 Zhang H.H....Burgess A.W. (Int. J. Cancer 2009)
    409. The APC Variant p.Glu1317Gln predisposes to colorectal adenomas by a novel mechanism of relaxing the target for tumorigenic somatic APC mutations. (PubMed id 19701947)1 Dallosso A.R....Cheadle J.P. (Hum. Mutat. 2009)
    410. Polymorphisms in the adenomatous polyposis coli gene in Slovak families suspected of FAP. (PubMed id 20027139)1 Wachsmannova-Matelova L....Zajac V. (Neuro Endocrinol. Lett. 2009)
    411. Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients. (PubMed id 19470943)1 Richiardi L....Merletti F. (J. Clin. Oncol. 2009)
    412. Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. (PubMed id 19035518)1 Elander N....SAPderkvist P. (Mol. Carcinog. 2009)
    413. A two-step model for colon adenoma initiation and progression caused by APC loss. (PubMed id 19450512)1 Phelps R.A....Jones D.A. (Cell 2009)
    414. APC somatic mosaicism in a patient with Gardner syndrome carrying the E1573X mutation: report of a case. (PubMed id 19617769)1 Filipe B....Nobre LeitALo C. (Dis. Colon Rectum 2009)
    415. Novel human pathological mutations. Gene symbol: APC. Disease: Adenomatous polyposis coli. (PubMed id 19694001)1 Mavrogiannis L.A....Charlton R.S. (Hum. Genet. 2009)
    416. The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. (PubMed id 19240029)1 Uchiki T....Goldberg A.L. (J. Biol. Chem. 2009)
    417. Nup358 interacts with APC and plays a role in cell polarization. (PubMed id 19654215)1 Murawala P....Joseph J. (J. Cell. Sci. 2009)
    418. The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme. (PubMed id 19426738)1 Godin K.S....Varani G. (J. Mol. Biol. 2009)
    419. The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients. (PubMed id 19309276)1 Chen S.P....Harn H.J. (Genet Test Mol Biomarkers 2009)
    420. Novel association of APC with intermediate filaments identified using a new versatile APC antibody. (PubMed id 19845967)1 Wang Y....Neufeld K.L. (BMC Cell Biol. 2009)
    421. APC mutation spectrum of Norwegian familial adenomatous polyposis families: high ratio of novel mutations. (PubMed id 19444466)1 Andresen P.A....Gedde-Dahl T. (J. Cancer Res. Clin. Oncol. 2009)
    422. Original CIN: reviewing roles for APC in chromosome instability. (PubMed id 18519734)1 Rusan N.M. and Peifer M. (J. Cell Biol. 2008)
    423. Desmoid tumor: a disease opportune for molecular insights. (PubMed id 17952864)1 Kotiligam D....Lev D. (Histol. Histopathol. 2008)
    424. The in vivo rate of somatic adenomatous polyposis coli mutation. (PubMed id 18321998)1 Hornsby C....Tomlinson I. (Am. J. Pathol. 2008)
    425. Adenomatous polyposis coli alteration in digestive endocrine tumours: correlation with nuclear translocation of beta-catenin and chromosomal instability. (PubMed id 18632876)1 Pizzi S....Rindi G. (Endocr. Relat. Cancer 2008)
    426. Germline APC mutations are not commonly seen in children with sporadic hepatoblastoma. (PubMed id 18955873)1 Harvey J....Hinds R. (J. Pediatr. Gastroenterol. Nutr. 2008)
    427. Gonadal mosaicism and familial adenomatous polyposis. (PubMed id 18026870)1 Schwab A.L....Burt R.W. (Fam. Cancer 2008)
    428. Novel self-association of the APC molecule affects APC clusters and cell migration. (PubMed id 18477604)1 Li Z....NAothke I.S. (J. Cell. Sci. 2008)
    429. APC mutation spectrum in ileoanal pouch polyps resembles that of colorectal polyps. (PubMed id 18418860)1 Will O.C....Tomlinson I. (Br J Surg 2008)
    430. Germline hypermethylation of the APC promoter is not a frequent cause of familial adenomatous polyposis in APC/MUTYH mutation negative families. (PubMed id 18027849)1 Romero-GimAcnez J....Arango D. (Int. J. Cancer 2008)
    431. Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposis. (PubMed id 18166348)1 MenAcndez M....CapellA! G. (Gastroenterology 2008)
    432. Methylation of the adenomatous polyposis coli (APC) gene in human placenta and hypermethylation in choriocarcinoma cells. (PubMed id 18485586)1 Wong N.C....Saffery R. (Cancer Lett. 2008)
    433. Thyroid cancer in two siblings with FAP syndrome and APC mutation. (PubMed id 17665205)1 Brozek I....Limon J. (Int J Colorectal Dis 2008)
    434. Quantitative, spatial resolution of the epigenetic field effect in prostate cancer. (PubMed id 18058812)1 Mehrotra J....Mazumder A. (Prostate 2008)
    435. Epigenetic alterations of CDH1 and APC genes: relationship with activation of Wnt/beta-catenin pathway in invasive ductal carcinoma of breast. (PubMed id 18662704)1 Prasad C.P....Ralhan R. (Life Sci. 2008)
    436. Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype. (PubMed id 18224684)1 Miyaki M....Mori T. (Int. J. Cancer 2008)
    437. Presence of a TA haplotype in the APC gene containing the common 1822 polymorphism and colorectal adenoma. (PubMed id 18632657)1 Egan J.B....Thompson P.A. (Cancer Res. 2008)
    438. The spectrum of the APC pathogenic mutations in Slovak FAP patients. (PubMed id 18987576)1 Matelova L....Zajac V. (Neuro Endocrinol. Lett. 2008)
    439. Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours. (PubMed id 18387968)1 Kohler E.M....Schneikert J. (Hum. Mol. Genet. 2008)
    440. APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase. (PubMed id 19061640)1 Su Y....Liu B. (Mol. Cell 2008)
    441. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (J. Proteome Res. 2008)
    442. American founder mutation for attenuated familial adenomatous polyposis. (PubMed id 18063416)1 Neklason D.W....Burt R.W. (Clin. Gastroenterol. Hepatol. 2008)
    443. Promoter hypermethylation in circulating blood cells identifies prostate cancer progression. (PubMed id 17960617)1 RouprA-t M....Hamdy F.C. (Int. J. Cancer 2008)
    444. The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. (PubMed id 18502210)1 Breitman M....Rosin-Arbesfeld R. (Biochim. Biophys. Acta 2008)
    445. Identification of a novel duplication in the APC gene using multiple ligation probe amplification in a patient with familial adenomatous polyposis. (PubMed id 18406876)1 Pedace L....Grammatico P. (Cancer Genet. Cytogenet. 2008)
    446. Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli. (PubMed id 18454178)1 Kouzmenko A.P....Kato S. (Oncogene 2008)
    447. Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. (PubMed id 18451217)1 Suehiro Y....Hamilton S.R. (Clin. Cancer Res. 2008)
    448. Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells. (PubMed id 18774639)1 Wang H....Chakrabarty S. (Cancer Lett. 2008)
    449. [Germline mutation of adenomatous polyposis coli gene in Chinese patients with familial adenomatous polyposis]. (PubMed id 18393246)1 Wang T.T....Zhang X.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    450. Sporadic desmoid tumor in an Ashkenazi patient homozygous for the APC*I1307K gene mutation. (PubMed id 18770064)1 Zauber P....Bishop T. (Acta Oncol 2008)
    451. Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. (PubMed id 18403596)1 Gaspar C....Fodde R. (Am. J. Pathol. 2008)
    452. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    453. Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model. (PubMed id 17968317)1 Rao P.R....Shashidhara L.S. (Oncogene 2008)
    454. APC promoter methylation and protein expression in hepatocellular carcinoma. (PubMed id 17973119)1 Csepregi A....Ebert M.P. (J. Cancer Res. Clin. Oncol. 2008)
    455. [Detection of adenomatous polyposis coli gene mutations in 31 familial adenomatous polyposis families by using denaturing high performance liquid chromatography]. (PubMed id 18393237)1 Cai S.R....Zheng S. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    456. A novel function of adenomatous polyposis coli (APC) in regulating DNA repair. (PubMed id 18662849)1 Jaiswal A.S. and Narayan S. (Cancer Lett. 2008)
    457. Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition. (PubMed id 18632987)1 Wang Y....Neufeld K.L. (Mol. Biol. Cell 2008)
    458. Ligand-dependent interaction between estrogen receptor alpha and adenomatous polyposis coli. (PubMed id 18498351)1 Kouzmenko A.P....Kato S. (amp 2008)
    459. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. (PubMed id 18632633)1 Nagel R....Agami R. (Cancer Res. 2008)
    460. Low-grade gastric adenomas/dysplasias: phenotypic expression, DNA ploidy pattern, and LOH at microsatellites linked to the APC gene. (PubMed id 17964080)1 Tanaka A....Hattori T. (Pathol. Res. Pract. 2008)
    461. Somatic APC inactivation mechanisms in sporadic colorectal cancer cases in Hungary. (PubMed id 18369740)1 KA!mory E....Csuka O. (Pathol. Oncol. Res. 2008)
    462. Meningiomas exhibit loss of heterozygosity of the APC gene. (PubMed id 18066497)1 PeA8ina-Slaus N....CupiA8 H. (J. Neurooncol. 2008)
    463. Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. (PubMed id 17572842)1 Senda T....Shimomura A. (Med Mol Morphol 2007)
    464. Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis. (PubMed id 17297457)1 Qian J....Groden J. (Oncogene 2007)
    465. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. (PubMed id 17227893)1 Dikovskaya D....NAothke I.S. (J. Cell Biol. 2007)
    466. IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli. (PubMed id 17255093)1 Sharma M. and Henderson B.R. (J. Biol. Chem. 2007)
    467. [Methylation status and protein expression of adenomatous polyposis coli (APC) gene in breast cancer]. (PubMed id 17562262)1 Liu Z....Zhang Q. (Ai Zheng 2007)
    468. Chemical dissection of the APC Repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3. (PubMed id 17910481)1 Ferrarese A....Pinna L.A. (Biochemistry 2007)
    469. Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein. (PubMed id 17126424)1 Mahadevaiyer S....Gumbiner B.M. (Biochim. Biophys. Acta 2007)
    470. Mutational screening of the APC gene in Chilean families with familial adenomatous polyposis: nine novel truncating mutations. (PubMed id 17963004)1 De la Fuente M.K....LA^pez-KAPstner F. (Dis. Colon Rectum 2007)
    471. [Effect of adenomatous polyposis coli(APC) promoter methylation on gene transcription in lung cancer cell lines]. (PubMed id 17562260)1 Zhang L.X....Zhang J.N. (Ai Zheng 2007)
    472. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. (PubMed id 17599059)2 Kawasaki Y....Akiyama T. (Oncogene 2007)
    473. The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients. (PubMed id 18265644)1 Wang J.Y....Lin S.R. (Hepatogastroenterology 2007)
    474. May the APC gene somatic mutations in tumor tissues influence the clinical features of Chinese sporadic colorectal cancers? (PubMed id 17653897)1 Liu X....Wang Y. (Acta Oncol 2007)
    475. Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner. (PubMed id 17189293)1 Schneikert J....Behrens J. (Hum. Mol. Genet. 2007)
    476. Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations. (PubMed id 17505512)1 Thirlwell C....Tomlinson I.P. (Br. J. Cancer 2007)
    477. A splice-site mutation in exon 4 of the APC gene in a family with attenuated familial adenomatous polyposis. (PubMed id 17410430)1 Murphy S.J....Morrison P.J. (Dig. Dis. Sci. 2007)
    478. Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. (PubMed id 17192415)1 Kroboth K....NAothke I.S. (Mol. Biol. Cell 2007)
    479. APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'. (PubMed id 17135276)1 Latchford A....Silver A. (Hum. Mol. Genet. 2007)
    480. Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC. (PubMed id 17588722)1 Kurzik-Dumke U. and Czaja J. (Cell. Signal. 2007)
    481. The AAPC case, with an early onset of colorectal cancer. (PubMed id 16710723)1 Plawski A....Slomski R. (Int J Colorectal Dis 2007)
    482. [Expression and significance of APC, beta-catenin, C-myc, and Cyclin D1 proteins in colorectal carcinoma]. (PubMed id 17927853)1 Dai W.B....Tang D.Y. (Ai Zheng 2007)
    483. [Spatial-temporal distribution of glycogen synthase kinase 3beta and adenomatous polyposis coli protein are involved in the injury and repair of airway epithelial cells induced by scratching]. (PubMed id 17437043)1 Zhu M....Wu R.L. (Sheng Li Xue Bao 2007)
    484. Analysis of APC/beta-catenin genes mutations and Wnt signalling pathway in desmoid-type fibromatosis. (PubMed id 17558858)1 Jilong Y....Xiongzeng Z. (Pathology 2007)
    485. Modeling of a human circadian mutation yields insights into clock regulation by PER2. (PubMed id 17218255)1 Xu Y....PtA!cek L.J. (Cell 2007)
    486. Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin. (PubMed id 17418091)1 Seo E. and Jho E.H. (Biochem. Biophys. Res. Commun. 2007)
    487. The mutation spectrum of the APC gene in Turkish patients with familial adenomatous polyposis. (PubMed id 17882487)1 Tunca B....Yilmazlar T. (Dis. Colon Rectum 2007)
    488. Impact of adenomatous polyposis coli (APC) tumor supressor gene in human colon cancer cell lines on cell cycle arrest by apigenin. (PubMed id 17620292)1 Chung C.S....Birt D.F. (Mol. Carcinog. 2007)
    489. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    490. Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors. (PubMed id 17905526)1 Nikuseva-MartiA8 T....BuliA8-Jakus F. (Pathol. Res. Pract. 2007)
    491. Clinical features of familial adenomas polyps in Chinese and establishment of its immortal lymphocyte cell lines. (PubMed id 17569124)1 Cai S.R....Zheng S. (World J. Gastroenterol. 2007)
    492. Mechanism of adenomatous polyposis coli (APC)-mediated blockage of long-patch base excision repair. (PubMed id 17176113)1 Jaiswal A.S....Narayan S. (Biochemistry 2006)
    493. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    494. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PubMed id 17110338)1 Wang X....Balch W.E. (Cell 2006)
    495. Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. (PubMed id 16951153)1 Sodir N.M....Laird P.W. (Cancer Res. 2006)
    496. Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel. (PubMed id 16619216)1 BrA1cher B.L....Sarbia M. (Int. J. Cancer 2006)
    497. Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells. (PubMed id 16798748)1 Yang J....Liu C. (J. Biol. Chem. 2006)
    498. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    499. Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. (PubMed id 16525027)1 Kita K....Waterman-Storer C.M. (Mol. Biol. Cell 2006)
    500. Novel germline mutations in the APC gene of Cypriot patients with familial and sporadic adenomatous polyposis. (PubMed id 16650078)1 Hadjisavvas A....Kyriacou K. (Clin. Genet. 2006)
    501. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. (PubMed id 16510875)1 Gomes N.P....Espinosa J.M. (amp 2006)
    502. Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. (PubMed id 16293619)1 Choi H.J....Weis W.I. (J. Biol. Chem. 2006)
    503. Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology. (PubMed id 16804979)1 Bortlik M....Lukas M. (World J. Gastroenterol. 2006)
    504. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    505. Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases. (PubMed id 17028196)1 Nadauld L.D....Jones D.A. (J. Biol. Chem. 2006)
    506. Mutational analysis of the APC gene in cribriform-morula variant of papillary thyroid carcinoma. (PubMed id 16680592)1 Uchino S....Miyauchi A. (World J Surg 2006)
    507. Genomic instability in precancerous lesions before inactivation of tumor suppressors p53 and APC in patients. (PubMed id 16855398)1 Yang Y....Li C.J. (Cell Cycle 2006)
    508. Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma. (PubMed id 16426911)1 Nair K.S....Chetty R. (Hum. Pathol. 2006)
    509. Wnt signalling and the actin cytoskeleton. (PubMed id 17143298)1 Akiyama T. and Kawasaki Y. (Oncogene 2006)
    510. Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. (PubMed id 16461775)1 Sieber O.M....Tomlinson I.P. (Gut 2006)
    511. Truncated APC is required for cell proliferation and DNA replication. (PubMed id 16450383)1 Schneikert J. and Behrens J. (Int. J. Cancer 2006)
    512. The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin. (PubMed id 16753179)1 Liu J....Xu W. (J. Mol. Biol. 2006)
    513. Examination of actin and microtubule dependent APC localisations in living mammalian cells. (PubMed id 16423286)1 Langford K.J....Morrison E.E. (BMC Cell Biol. 2006)
    514. Detection of APC gene deletion by double competitive polymerase chain reaction in patients with familial adenomatous polyposis. (PubMed id 16820884)1 Takahashi M....Tsukada T. (Int. J. Oncol. 2006)
    515. The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. (PubMed id 16699180)1 Eisinger A.L....Jones D.A. (J. Biol. Chem. 2006)
    516. Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients. (PubMed id 15833136)1 Mihalatos M....Nasioulas G. (BMC Cancer 2005)
    517. APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance. (PubMed id 15943410)1 Hsieh J.S....Wang J.Y. (Am Surg 2005)
    518. The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death. (PubMed id 16007220)1 Kuninaka S....Saya H. (Oncogene 2005)
    519. Hereditary colon cancer--part I. (PubMed id 15821699)1 Merg A....Howe J.R. (Curr Probl Surg 2005)
    520. Analysis of Wnt/Beta catenin signalling in desmoid tumors. (PubMed id 15832580)1 Tejpar S....Cassiman J.J. (Acta Gastroenterol. Belg. 2005)
    521. Mutation spectrum of the APC gene in 83 Korean FAP families. (PubMed id 16088911)1 Kim D.W....Park J.G. (Hum. Mutat. 2005)
    522. [Roles of Wnt-1, beta-catenin and adenomatous polyposis coli in the differentiation and proliferation of oral squamous cell carcinoma]. (PubMed id 16329837)1 Zhang W.M. and Gao Y. (Zhonghua Kou Qiang Yi Xue Za Zhi 2005)
    523. Large-scale analysis of the human ubiquitin-related proteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (Proteomics 2005)
    524. The tumor suppressor adenomatous polyposis coli gene is associated with susceptibility to schizophrenia. (PubMed id 15768050)1 Cui D.H....Yao H. (Mol. Psychiatry 2005)
    525. Systematic peptide array-based delineation of the differential beta-catenin interaction with Tcf4, E-cadherin, and adenomatous polyposis coli. (PubMed id 15591320)1 Gail R....Wittinghofer A. (J. Biol. Chem. 2005)
    526. Large submicroscopic genomic APC deletions are a common cause of typical familial adenomatous polyposis. (PubMed id 15689459)1 Aretz S....Friedl W. (J. Med. Genet. 2005)
    527. Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes. (PubMed id 16212417)1 Catimel B....Nice E. (J. Proteome Res. 2005)
    528. Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC. (PubMed id 16382042)1 Chang W.C....Clapper M.L. (Ann. N. Y. Acad. Sci. 2005)
    529. Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PubMed id 15778465)1 Benzinger A.... Hermeking H. (Mol. Cell. Proteomics 2005)
    530. APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. (PubMed id 16030254)1 Green R.A....Kaplan K.B. (Mol. Biol. Cell 2005)
    531. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. (PubMed id 16199882)1 Hino S....Kikuchi A. (Mol. Cell. Biol. 2005)
    532. Genetic analyses in consecutive israeli jewish colorectal cancer patients. (PubMed id 15929773)1 Fidder H.H....Friedman E. (Am. J. Gastroenterol. 2005)
    533. Analysis of germline mutations in the APC gene in familial adenomatous polyposis patients. (PubMed id 15952110)1 Liu X.R....Wang Y.P. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    534. Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function. (PubMed id 15327769)1 Xing Y....Xu W. (Mol. Cell 2004)
    535. Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. (PubMed id 15561772)1 Tighe A....Taylor S.S. (J. Cell. Sci. 2004)
    536. Expression of the proliferating cell nuclear antigen and protein products of tumour suppressor genes in the human foetal testis. (PubMed id 14871261)1 MariA8 S....VlahoviA8 M. (Andrologia 2004)
    537. Somatic mutations of APC gene in carcinomas from hereditary non-polyposis colorectal cancer patients. (PubMed id 15040027)1 Huang J....Zhang S.Z. (World J. Gastroenterol. 2004)
    538. An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. (PubMed id 15123239)1 Boisguerin P....Volkmer-Engert R. (amp 2004)
    539. Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway. (PubMed id 14991743)1 Deng J....Hung M.C. (Mol. Carcinog. 2004)
    540. Colorectal cancer prevention. (PubMed id 15375803)1 Kauh J. and Umbreit J. (Curr Probl Cancer 2004)
    541. Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. (PubMed id 15327768)1 Ha N.C....Weis W.I. (Mol. Cell 2004)
    542. The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. (PubMed id 15525529)1 Hamada F. and Bienz M. (Dev. Cell 2004)
    543. Novel germline mutations in the adenomatous polyposis coli gene in Polish families with familial adenomatous polyposis. (PubMed id 14729851)1 Plawski A....SA8omski R. (J. Med. Genet. 2004)
    544. Analysis of adenomatous polyposis coli gene expression, APC locus-microsatellite instability and APC promoter methylation in the progression of melanocytic tumours. (PubMed id 15257316)1 Korabiowska M....Brinck U. (Mod. Pathol. 2004)
    545. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. (PubMed id 15572129)1 Watanabe T....Kaibuchi K. (Dev. Cell 2004)
    546. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. (PubMed id 15161933)1 Meek S.E....Piwnica-Worms H. (J. Biol. Chem. 2004)
    547. Influence of diet containing lyophilized Enterococcus faecium M-74 with organic selenium on tumor incidence in Apc1638N mice. (PubMed id 15640937)1 HlubinovA! K....Altaner C. (Neoplasma 2004)
    548. The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. (PubMed id 15190067)1 Jette C....Jones D.A. (J. Biol. Chem. 2004)
    549. Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. (PubMed id 14679305)1 Faux M.C....Burgess A.W. (J. Cell. Sci. 2004)
    550. MUC1 can interact with adenomatous polyposis coli in breast cancer. (PubMed id 15020226)1 Hattrup C.L....Gendler S.J. (Biochem. Biophys. Res. Commun. 2004)
    551. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    552. Familial adenomatous polyposis patients without an identified APC germline mutation have a severe phenotype. (PubMed id 14724162)4 Bisgaard M.L....BA1low S. (Gut 2004)
    553. Familial adenomatous polyposis: aberrant splicing due to missense or silent mutations in the APC gene. (PubMed id 15459959)1 Aretz S....Friedl W. (Hum. Mutat. 2004)
    554. Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. (PubMed id 12800196)1 SarriA^ D....Palacios J. (Int. J. Cancer 2003)
    555. Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. (PubMed id 14662741)1 Green R.A. and Kaplan K.B. (J. Cell Biol. 2003)
    556. Genotype and phenotype of patients with both familial adenomatous polyposis and thyroid carcinoma. (PubMed id 14574158)1 Truta B....Sleisenger M.H. (Fam. Cancer 2003)
    557. Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta. (PubMed id 14520463)1 Rask K....Sundfeldt K. (Br. J. Cancer 2003)
    558. Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription. (PubMed id 12606575)1 Rosin-Arbesfeld R....Bienz M. (EMBO J. 2003)
    559. [Expression of members of the cadherin-/catenin-protein family in juvenile angiofibromas]. (PubMed id 12800081)1 Rippel C....Schick B. (Laryngorhinootologie 2003)
    560. Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. (PubMed id 12820959)1 Wu G....Pavletich N.P. (Mol. Cell 2003)
    561. Novel mutations of the APC gene in familial adenomatous polyposis in Greek patients. (PubMed id 12581900)1 Mihalatos M....Nasioulas G. (Cancer Genet. Cytogenet. 2003)
    562. The mutation spectrum of the APC gene in FAP patients from southern Italy: detection of known and four novel mutations. (PubMed id 14961559)1 De Rosa M....Izzo P. (Hum. Mutat. 2003)
    563. Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers. (PubMed id 12647217)1 Furuta K....Hamilton S.R. (Virchows Arch. 2003)
    564. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. (PubMed id 12952940)1 Topol L....Yang Y. (J. Cell Biol. 2003)
    565. APC haploinsufficiency, but not CTNNB1 or CDH1 gene mutations, accounts for a fraction of familial adenomatous polyposis patients without APC truncating mutations. (PubMed id 14691304)1 Venesio T....Ranzani G.N. ( a journal of technical methods and pathology 2003)
    566. Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein. (PubMed id 12628243)1 Tickenbrock L....MA1ller O. (J. Mol. Biol. 2003)
    567. A nonsense mutation in exon 8 of the APC gene (Arg283Ter) causes clinically variable FAP in a Malaysian Chinese family. (PubMed id 12901799)1 Mohamed Z....Yew T.H. (Cancer Sci. 2003)
    568. Genetic analysis of familial colorectal cancer in Israeli Arabs. (PubMed id 12655564)1 Chen-Shtoyerman R.... Fireman Z. (Hum. Mutat. 2003)
    569. Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation. (PubMed id 12955080)1 Fagman H....Nilsson M. (Oncogene 2003)
    570. Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway. (PubMed id 12538344)1 Campbell P.M. and Szyf M. (Carcinogenesis 2003)
    571. Role of APC and DNA mismatch repair genes in the development of colorectal cancers. (PubMed id 14672538)1 Narayan S. and Roy D. (Mol. Cancer 2003)
    572. Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. (PubMed id 12000790)1 Amit S....Alkalay I. (amp 2002)
    573. Adenomatous polyposis coli truncation alters cytoskeletal structure and microtubule stability in early intestinal tumorigenesis. (PubMed id 12504226)1 Hughes S.A....Bertagnolli M.M. (J. Gastrointest. Surg. 2002)
    574. Identification of a link between the tumour suppressor APC and the kinesin superfamily. (PubMed id 11912492)1 Jimbo T....Akiyama T. (Nat. Cell Biol. 2002)
    575. Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. (PubMed id 11891193)1 Abraham S.C....Klimstra D.S. (Am. J. Pathol. 2002)
    576. Mutations of the adenomatous polyposis coli gene in areca quid and tobacco-associated oral squamous cell carcinomas in Taiwan. (PubMed id 12165057)4 Kok S.H....Kuo M.Y. (amp 2002)
    577. The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli. (PubMed id 11856748)1 Mulholland D.J....Nelson C.C. (J. Biol. Chem. 2002)
    578. Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. (PubMed id 11972058)1 Homma M.K....Homma Y. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    579. The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. (PubMed id 12045208)1 Albuquerque C....Smits R. (Hum. Mol. Genet. 2002)
    580. Pathogenic mutations and rare variants of the APC gene identified in 75 Belgian patients with familial adenomatous polyposis by fluorescent enzymatic mutation detection (EMD). (PubMed id 12173026)1 Michils G....Matthijs G. (Eur. J. Hum. Genet. 2002)
    581. Gut-enriched KrA1ppel-like factor regulates colonic cell growth through APC/beta-catenin pathway. (PubMed id 12387883)1 Stone C.D....Tseng C.C. (FEBS Lett. 2002)
    582. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. (PubMed id 11955436)1 Liu C.... He X. (Cell 2002)
    583. Different combinations of biallelic APC mutation confer different growth advantages in colorectal tumours. (PubMed id 11809680)1 Cheadle J.P....Sampson J.R. (Cancer Res. 2002)
    584. APC germline mutations identified in Czech patients with familial adenomatous polyposis. (PubMed id 11933206)1 KohoutovA! M....Kapras J. (Hum. Mutat. 2002)
    585. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    586. Different familial adenomatous polyposis phenotypes resulting from deletions of the entire APC exon 15. (PubMed id 12136240)1 Su L.K....Lynch P.M. (Hum. Genet. 2002)
    587. The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1). (PubMed id 12070164)1 Tickenbrock L....Muller O. (J. Biol. Chem. 2002)
    588. Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC. (PubMed id 12124804)1 Reifenberger J....Reifenberger G. (Int. J. Cancer 2002)
    589. Predictive genetic testing: mediators and moderators of anxiety. (PubMed id 12508668)1 Michie S....Marteau T.M. (Int J Behav Med 2002)
    590. Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. (PubMed id 12093899)1 Smith G....Wolf C.R. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    591. Low frequency of beta-catenin gene mutations in pilomatricoma. (PubMed id 12575848)1 Ha S.J....Kim J.W. (Acta Derm. Venereol. 2002)
    592. Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis. (PubMed id 11956815)1 Hao X....Talbot I.C. (Virchows Arch. 2002)
    593. Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. (PubMed id 11809682)1 Usadel H....Sidransky D. (Cancer Res. 2002)
    594. Structure of the amino-terminal nuclear export domain of the APC tumor suppressor protein. (PubMed id 12485844)1 Tickenbrock L....Muller O. (Ann. N. Y. Acad. Sci. 2002)
    595. Attenuated APC alleles produce functional protein from internal translation initiation. (PubMed id 12034871)1 Heppner Goss K....Groden J. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    596. Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. (PubMed id 11943150)1 Nakamura M.... Ping Lu K. (FEBS Lett. 2002)
    597. Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. (PubMed id 12072559)1 Anderson C.B....White R.L. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    598. Mutations of the APC gene in human sporadic colorectal cancers. (PubMed id 12374230)1 De Filippo C....Dolara P. (Scand. J. Gastroenterol. 2002)
    599. A silent mutation in exon 14 of the APC gene is associated with exon skipping in a FAP family. (PubMed id 11768390)1 Montera M....Mareni C. (J. Med. Genet. 2001)
    600. Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A. (PubMed id 11297546)1 Yamamoto H....Kikuchi A. (J. Biol. Chem. 2001)
    601. The Asp1822Val variant of the APC gene is a common polymorphism without clinical implications. (PubMed id 11584047)1 Ruiz-Ponte C....Carracedo A. (J. Med. Genet. 2001)
    602. Phenotypic APC resistance in carriers of the A20210 prothrombin mutation is associated with an increased risk of venous thrombosis. (PubMed id 11583311)4 Castaman G....Rodeghiero F. (Thromb. Haemost. 2001)
    603. Human APC2 localization and allelic imbalance. (PubMed id 11691822)2 Jarrett C.R.... Byers S.W. (Cancer Res. 2001)
    604. ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A. (PubMed id 11585828)1 Galea M.A....Henderson B.R. (J. Biol. Chem. 2001)
    605. Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization. (PubMed id 11470413)1 Nakamura M....Lu K.P. (Curr. Biol. 2001)
    606. The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. (PubMed id 11348595)1 Huber A.H. and Weis W.I. (Cell 2001)
    607. Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of the adenomatous polyposis coli (APC) tumor suppressor gene. (PubMed id 11241666)1 Jaiswal A.S. and Narayan S. (J. Cell. Biochem. 2001)
    608. Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p. (PubMed id 11696422)4 Abraham S.C....Hruban R.H. (Am. J. Pathol. 2001)
    609. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. (PubMed id 11283619)1 Kaplan K.B....NAothke I.S. (Nat. Cell Biol. 2001)
    610. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. (PubMed id 11389840)1 Liu J.... Matsunami N. (Mol. Cell 2001)
    611. A novel 3' mutation in the APC gene in a family presenting with a desmoid tumour. (PubMed id 11768389)1 Eccles D....Ross F. (J. Med. Genet. 2001)
    612. Molecular and clinical characteristics in 32 families affected with familial adenomatous polyposis. (PubMed id 11748858)1 Hutter P....Soravia C. (Hum. Mutat. 2001)
    613. Topoisomerase-I- and Alu-mediated genomic deletions of the APC gene in familial adenomatous polyposis. (PubMed id 11409872)1 Cao X.... Cheah P.Y. (Hum. Genet. 2001)
    614. Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. (PubMed id 11157977)1 Reinacher-Schick A. and Gumbiner B.M. (J. Cell Biol. 2001)
    615. Gene-environment interactions in pancreatic cancer. (PubMed id 12120227)4 Malats N. (Pancreatology 2001)
    616. Absence of mutations in the beta-catenin and adenomatous polyposis coli genes in papillary and follicular thyroid carcinomas. (PubMed id 11696170)1 Miyake N....Terada T. (Pathol. Int. 2001)
    617. Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli. (PubMed id 11466687)4 Su L.K....Vauthey J.N. (Cancer 2001)
    618. Mutation analysis of the adenomatous polyposis coli (APC) gene in northwest Spanish patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer. (PubMed id 11668620)1 Ruiz-Ponte C....Barros F. (Hum. Mutat. 2001)
    619. Crystal structure of a beta-catenin/Tcf complex. (PubMed id 11136974)1 Graham T.A.... Xu W. (Cell 2000)
    620. The colorectal tumour suppressor APC is present in the NMDA-receptor-PSD-95 complex in the brain. (PubMed id 11029657)1 Yanai H....Akiyama T. (amp 2000)
    621. Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein. (PubMed id 11050185)1 Zhang F....Neufeld K.L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    622. The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. (PubMed id 10656683)1 Ishidate T.... Akiyama T. (Oncogene 2000)
    623. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (Genome Res. 2000)
    624. GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. (PubMed id 10698523)1 Ikeda S....Kikuchi A. (Oncogene 2000)
    625. Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposis. (PubMed id 10982189)1 Su L.K.... Lynch P.M. (Hum. Genet. 2000)
    626. Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. (PubMed id 11035805)1 Neufeld K.L....White R.L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    627. Regulation and function of the interaction between the APC tumour suppressor protein and EB1. (PubMed id 10773885)1 Askham J.M....Morrison E.E. (Oncogene 2000)
    628. Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes. (PubMed id 11129339)1 Saffery R....Choo K.H. (Hum. Genet. 2000)
    629. Nasopharyngeal angiofibroma: an APC-gene-associated tumor? (PubMed id 11112217)4 Guertl B....Hoefler G. (Hum. Pathol. 2000)
    630. Role of the adenomatous polyposis coli gene product in human cardiac development and disease. (PubMed id 10749862)1 Rezvani M. and Liew C.C. (J. Biol. Chem. 2000)
    631. Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. (PubMed id 10330403)1 Fagotto F....Costantini F. (J. Cell Biol. 1999)
    632. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. (PubMed id 10074433)1 Hart M....Polakis P. (Curr. Biol. 1999)
    633. EB/RP gene family encodes tubulin binding proteins. (PubMed id 10188731)1 Juwana J.-P.... Renner C. (Int. J. Cancer 1999)
    634. Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level. (PubMed id 10545404)1 Hsi L.C....Eling T.E. (Carcinogenesis 1999)
    635. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. (PubMed id 10092233)1 Seeling J.M....Virshup D.M. (Science 1999)
    636. An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. (PubMed id 10228155)1 Kitagawa M....Nakayama K. (EMBO J. 1999)
    637. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. (PubMed id 10330181)1 Kishida S....Kikuchi A. (Mol. Cell. Biol. 1999)
    638. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (PubMed id 9707618)1 Tanaka S.... Sugimachi K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    639. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. (PubMed id 9637688)1 Fang G.... Kirschner M.W. (Genes Dev. 1998)
    640. Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level. (PubMed id 9734785)1 Nakamura T....Akiyama T. (amp 1998)
    641. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. (PubMed id 9482734)1 Ikeda S....Kikuchi A. (EMBO J. 1998)
    642. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. (PubMed id 9601641)1 Hart M.J....Polakis P. (Curr. Biol. 1998)
    643. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. (PubMed id 9811605)1 Kramer E.R.... Peters J.-M. (Curr. Biol. 1998)
    644. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. (PubMed id 9660858)1 Taylor S.S.... McKeon F. (J. Cell Biol. 1998)
    645. Three-dimensional structure of the armadillo repeat region of beta-catenin. (PubMed id 9298899)1 Huber A.H....Weis W.I. (Cell 1997)
    646. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95. (PubMed id 9286858)1 Satoh K.... Akiyama T. (Genes Cells 1997)
    647. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. (PubMed id 9326658)1 Kiyono T....Ishibashi M. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    648. Adrenocorticotropin-independent macronodular adrenocortical hyperplasia associated with multiple colon adenomas/carcinomas which showed a point mutation in the APC gene. (PubMed id 9260769)4 Yamakita N....Yoshida T. (Intern. Med. 1997)
    649. APC mutations in familial adenomatous polyposis families in the Northwest of England. (PubMed id 9375853)1 Armstrong J.G....Evans D.G. (Hum. Mutat. 1997)
    650. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)
    651. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    652. Cranial desmoid tumor associated with homozygous inactivation of the adenomatous polyposis coli gene in a 2-year-old girl with familial adenomatous polyposis. (PubMed id 8608492)4 de Silva D.C....Dunlop M.G. (Cancer 1996)
    653. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    654. Somatic mutations of the APC gene in sporadic hepatoblastomas. (PubMed id 8764128)2 Oda H.... Ishikawa T. (Cancer Res. 1996)
    655. APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis. (PubMed id 8522331)4 van der Luijt R.B....Meera Khan P. (Hum. Genet. 1995)
    656. The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. (PubMed id 7890674)1 Rubinfeld B....Polakis P. (J. Biol. Chem. 1995)
    657. The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. (PubMed id 8521819)1 Baeg G.H....Akiyama T. (EMBO J. 1995)
    658. A 77-kDa protein associates with pp125FAK in mast cells and becomes tyrosine-phosphorylated by high affinity IgE receptor aggregation. (PubMed id 7744883)1 Hamawy M.M....Siraganian R.P. (J. Biol. Chem. 1995)
    659. The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. (PubMed id 7651399)1 Daniel J.M. and Reynolds A.B. (Mol. Cell. Biol. 1995)
    660. APC mutation associated with late onset of familial adenomatous polyposis. (PubMed id 7853377)4 Smith-Ravin J....Bodmer W. (J. Med. Genet. 1994)
    661. Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli. (PubMed id 8162051)4 Gayther S.A....Delhanty J.D. (Hum. Mol. Genet. 1994)
    662. Alleles of the APC gene: an attenuated form of familial polyposis. (PubMed id 8252630)1 Spirio L.... Otterud B. (Cell 1993)
    663. Identification of an alternative 5' untranslated region of the adenomatous polyposis coli gene. (PubMed id 8383094)1 Lambertz S. and Ballhausen W.G. (Hum. Genet. 1993)
    664. APC-Associated Polyposis Conditions (PubMed id 20301519)1 Pagon R.A....Stephens K. (1993)
    665. High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-22. (PubMed id 2797819)1 Ashton-Rickardt P.G....Wyllie A.H. (Oncogene 1989)
    666. Gardner syndrome in a man with an interstitial deletion of 5q. (PubMed id 3789010)1 Herrera L....Sandberg A.A. (Am. J. Med. Genet. 1986)
    667. Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis. (PubMed id 15375009)9 Chen J....Ebert M.P. (Carcinogenesis 2005)
    668. Impact of genetic versus environmental factors on the control of muscle glycogen synthase activation in twins. (PubMed id 15855312)9 Poulsen P....Vaag A. (Diabetes 2005)
    669. Promoter methylation inhibits APC gene expression by causing changes in chromatin conformation and interfering with the binding of transcription factor CCAAT-binding factor. (PubMed id 15087381)9 Deng G....Kim Y.S. (Cancer Res. 2004)
    670. Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. (PubMed id 15287021)9 BlAoker H....Helmke B.M. (amp 2004)
    671. Genotype-phenotype correlations in 19 Dutch cases with APC gene deletions and a literature review. (PubMed id 17568392)9 Nielsen M....Weiss M.M. (Eur. J. Hum. Genet. 2007)
    672. Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. (PubMed id 16621792)9 Sharma M....Henderson B.R. (J. Biol. Chem. 2006)
    673. Complete deletion of Apc results in severe polyposis in mice. (PubMed id 20010873)9 Cheung A.F....Jacks T. (Oncogene 2010)
    674. Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progression. (PubMed id 19789364)9 Hoque M.O....Parrella P. (amp 2009)
    675. Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues. (PubMed id 11062151)9 Iwamoto M....Maltzman T.H. (Carcinogenesis 2000)
    676. APC and beta-catenin in alveolar soft part sarcoma (ASPS)--immunohistochemical and molecular genetic analysis. (PubMed id 10834386)9 Kuhnen C....MA1ller O. (Pathol. Res. Pract. 2000)
    677. APC mutations in sporadic colorectal tumors: A mutational &quot;hotspot&quot; and interdependence of the &quot;two hits&quot;. (PubMed id 10737795)9 Rowan A.J....Tomlinson I.P. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    678. [Development of a detection system (APC yeast color assay) of APC mutations by color change of yeast]. (PubMed id 11193931)9 Furuuchi K. (Hokkaido Igaku Zasshi 2000)
    679. Activation of adenomatous polyposis coli (APC) gene expression by the DNA-alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine requires p53. (PubMed id 9388195)9 Narayan S. and Jaiswal A.S. (J. Biol. Chem. 1997)
    680. Mutations of APC and MYH in unrelated Italian patients with adenomatous polyposis coli. (PubMed id 16134147)9 Aceto G....Cama A. (Hum. Mutat. 2005)
    681. No evidence for involvement of beta-catenin and APC in urothelial carcinomas. (PubMed id 11956582)9 Stoehr R....Hartmann A. (Int. J. Oncol. 2002)
    682. Somatic mutations of the APC gene in primary breast cancers. (PubMed id 10854222)9 Furuuchi K....Moriuchi T. (Am. J. Pathol. 2000)
    683. Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis. (PubMed id 10213492)9 Dihlmann S....von Knebel Doeberitz M. (Cancer Res. 1999)
    684. Adenomatous polyposis coli protein is expressed in alternate stages of the ameloblast life cycle. (PubMed id 9839785)9 Wang M....Skobe Z. (J. Dent. Res. 1998)
    685. Somatic APC mosaicism: an underestimated cause of polyposis coli. (PubMed id 17604324)9 Hes F.J....Tops C.M. (Gut 2008)
    686. Low birth weight and zygosity status is associated with defective muscle glycogen and glycogen synthase regulation in elderly twins. (PubMed id 17698598)9 Poulsen P....Vaag A. (Diabetes 2007)
    687. [Promoter methylation and mRNA expression of APC gene in MCF10 breast cancer model]. (PubMed id 16608647)9 Yang J.L....Christman J.K. (Zhonghua Bing Li Xue Za Zhi 2006)
    688. Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy. (PubMed id 16115820)9 Lohi H....Minassian B.A. (Hum. Mol. Genet. 2005)
    689. Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma. (PubMed id 15793634)9 Brueckl W.M....Wein A. (Dis. Colon Rectum 2005)
    690. Somatic mutations in familial adenomatous polyps. Nuclear translocation of beta-catenin requires more than biallelic APC inactivation. (PubMed id 14502807)9 BlAoker H....Penzel R. (Am. J. Clin. Pathol. 2003)
    691. Methylation of CpG loci in 5'-flanking region alters steady-state expression of adenomatous polyposis coli gene in colon cancer cell lines. (PubMed id 11135372)9 Sakamoto Y....Kitazawa S. (J. Cell. Biochem. 2001)
    692. Somatic mutation rate of the APC gene. (PubMed id 11450991)9 Iwama T. (Jpn. J. Clin. Oncol. 2001)
    693. Genetic analysis of the APC gene regions involved in attenuated APC phenotype in Israeli patients with early onset and familial colorectal cancer. (PubMed id 11506490)9 Figer A....Friedman E. (Br. J. Cancer 2001)
    694. Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q. (PubMed id 11001924)9 Lamlum H....Tomlinson I. (Hum. Mol. Genet. 2000)
    695. Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover. (PubMed id 10980707)9 Henderson B.R. (Nat. Cell Biol. 2000)
    696. High resolution genetic map of the adenomatous polyposis coli gene (APC) region. (PubMed id 7604852)9 Olschwang S....Thomas G. (Am. J. Med. Genet. 1995)
    697. Synthetic peptides as probes for G protein function. Carboxyl-terminal G alpha s peptides mimic Gs and evoke high affinity agonist binding to beta-adrenergic receptors. (PubMed id 8063788)9 Rasenick M.M....Hamm H.E. (J. Biol. Chem. 1994)
    698. Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer. (PubMed id 8406987)9 McKie A.B....Lemoine N.R. (Int. J. Cancer 1993)
    699. Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization. (PubMed id 19339242)9 Prats C....Wojtaszewski J.F. (J. Biol. Chem. 2009)
    700. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. (PubMed id 19116273)9 Yang X.V....Griffin J.H. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    701. Control of glycogen deposition. (PubMed id 12829248)9 Ferrer J.C....Guinovart J.J. (FEBS Lett. 2003)
    702. Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma. (PubMed id 12673484)9 Kim J.C....Cho M.K. (Int J Colorectal Dis 2003)
    703. Regulation of glycogen synthase in skeletal muscle during exercise. (PubMed id 12864735)9 Nielsen J.N. and Richter E.A. (Acta Physiol. Scand. 2003)
    704. p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents. (PubMed id 11279192)9 Jaiswal A.S. and Narayan S. (J. Biol. Chem. 2001)
    705. Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. (PubMed id 11689703)9 Zhang F....Neufeld K.L. (Mol. Cell. Biol. 2001)
    706. Allelic loss involving the tumor suppressor genes APC and MCC and expression of the APC protein in the development of dysplasia and carcinoma in Barrett esophagus. (PubMed id 11338478)9 Bektas N....Sarbia M. (Am. J. Clin. Pathol. 2000)
    707. The identical 5' splice-site acceptor mutation in five attenuated APC families from Newfoundland demonstrates a founder effect. (PubMed id 10598803)9 Spirio L....Leppert M. (Hum. Genet. 1999)
    708. Germline and somatic mutations in exon 15 of the APC gene and K-ras mutations in duodenal adenomas in patients with familial adenomatous polyposis. (PubMed id 10440612)9 Norheim Andersen S....Rognum T.O. (Scand. J. Gastroenterol. 1999)
    709. Neuronal localization of the Adenomatous polyposis coli tumor suppressor protein. (PubMed id 10366023)9 Brakeman J.S....Baraban J.M. (Neuroscience 1999)
    710. APC genotype, polyp number, and surgical options in familial adenomatous polyposis. (PubMed id 9445111)9 Wu J.S....Church J.M. (Ann. Surg. 1998)
    711. Detection of APC mutations by a yeast-based protein truncation test (YPTT). (PubMed id 9559340)9 Suzuki T....Kanamaru R. (amp 1998)
    712. Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation. (PubMed id 8968744)9 Scott R.J....Maher E.R. (Hum. Mol. Genet. 1996)
    713. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (PubMed id 9038672)9 Giardiello F.M....Hamilton S.R. (Gut 1996)
    714. Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy. (PubMed id 7478622)9 Clarke A.R....Harrison D.J. (Oncogene 1995)
    715. Wild-type but not mutant APC associates with the microtubule cytoskeleton. (PubMed id 8033082)9 Smith K.J....Kinzler K.W. (Cancer Res. 1994)
    716. APC gene mutations in the mutation cluster region are rare in esophageal cancers. (PubMed id 7958689)9 Powell S.M....Meltzer S.J. (Gastroenterology 1994)
    717. Loss of APC protein expressed by human colonic epithelial cells and the appearance of a specific low-molecular-weight form is associated with apoptosis in vitro. (PubMed id 7927905)9 Browne S.J....Paraskeva C. (Int. J. Cancer 1994)
    718. APC mutation analysis by chemical cleavage of mismatch and a protein truncation assay in familial adenomatous polyposis. (PubMed id 7524601)9 Prosser J....Dunlop M.G. (Br. J. Cancer 1994)
    719. The APC gene product in normal and tumor cells. (PubMed id 8385345)9 Smith K.J....Vogelstein B. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    720. Increased stimulatory G protein in neoplastic human thyroid tissues. (PubMed id 1660629)9 Siperstein A.E....Clark O.H. (Surgery 1991)
    721. [Detection of APC gene germline mutation in Chinese familial adenomatous polyposis by direct sequencing in combination with multiplex ligation-dependent probe amplification]. (PubMed id 20367965)9 Jin P....Li S.R. (Zhonghua Yi Xue Za Zhi 2010)
    722. Oncogenic KRAS is not necessary for Wnt signalling activation in APC-associated FAP adenomas. (PubMed id 20196079)9 Obrador-Hevia A....CapellA! G. (J. Pathol. 2010)
    723. Methylated DAPK and APC promoter DNA detection in peripheral blood is significantly associated with apparent residual tumor and outcome. (PubMed id 19259700)9 Hoffmann A.C....Brabender J. (J. Cancer Res. Clin. Oncol. 2009)
    724. Expression of beta-catenin and its mechanism of delocalization in intestinal-type early gastric cancer based on mucin expression. (PubMed id 19475529)9 Lee S.H....Park d.o. .Y. (Histol. Histopathol. 2009)
    725. Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment. (PubMed id 18544618)9 Glintborg D....Wojtaszewski J.F. (J. Clin. Endocrinol. Metab. 2008)
    726. Expression of beta-catenin, E-cadherin and APC in canine mammary tumors. (PubMed id 17970048)9 Restucci B....Lo Muzio L. (Anticancer Res. 2007)
    727. Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. (PubMed id 17704816)9 Mitin N....Rossman K.L. (amp 2007)
    728. [Detection of free tumor-related DNA in the serum of breast cancer patients]. (PubMed id 18210882)9 Zhang J.J....Deng G.R. (Zhonghua Zhong Liu Za Zhi 2007)
    729. Balance between endoscopic and genetic information in the choice of ileorectal anastomosis for familial adenomatous polyposis. (PubMed id 17192888)9 Valanzano R....Tonelli F. (J Surg Oncol 2007)
    730. Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention. (PubMed id 16554443)9 Krieghoff E....Mayr B. (J. Cell. Sci. 2006)
    731. Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer. (PubMed id 17089036)9 Banno K....Aoki D. (Oncol. Rep. 2006)
    732. APC is a component of an organizing template for cortical microtubule networks. (PubMed id 15892196)9 Reilein A. and Nelson W.J. (Nat. Cell Biol. 2005)
    733. A quantitative promoter methylation profile of prostate cancer. (PubMed id 15623627)9 JerA^nimo C....Sidransky D. (Clin. Cancer Res. 2004)
    734. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. (PubMed id 15210940)9 Haigis K.M....Dove W.F. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    735. TGF-beta targets the Wnt pathway components, APC and beta-catenin, as Mv1Lu cells undergo cell cycle arrest. (PubMed id 15280661)9 Satterwhite D.J. and Neufeld K.L. (Cell Cycle 2004)
    736. Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle. (PubMed id 14656717)9 Liu Z....Barrett E.J. (Am. J. Physiol. Endocrinol. Metab. 2004)
    737. Identification of genomic deletions of the APC gene in familial adenomatous polyposis by two independent quantitative techniques. (PubMed id 15727247)9 Meuller J....Nordling M. (Genet. Test. 2004)
    738. Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel. (PubMed id 15041703)9 Dulaimi E....Cairns P. (Clin. Cancer Res. 2004)
    739. Cadherins, catenins and APC in pleural malignant mesothelioma. (PubMed id 14595746)9 Abutaily A.S....Roche W.R. (J. Pathol. 2003)
    740. [Roles of beta-catenin overexpression and adenomatous polyposis coli mutation in head and neck cancer]. (PubMed id 12872724)9 Takei S....Yamanaka N. (Nippon Jibiinkoka Gakkai Kaiho 2003)
    741. Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival. (PubMed id 11429699)9 Brabender J....Danenberg P.V. (Oncogene 2001)
    742. Frequent activation of the beta-catenin-Tcf signaling pathway in nonfamilial colorectal carcinomas with microsatellite instability. (PubMed id 11107173)9 Shitoh K....Nagai H. (amp 2001)
    743. Detection of tumor mutant APC DNA in plasma of patients with sporadic colorectal cancer. (PubMed id 10945171)9 Ling E....Lamprecht S.A. (In Vivo 2000)
    744. Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer. (PubMed id 10738270)9 Suto T....Nakamura S.i. (J Surg Oncol 2000)
    745. The APC protein binds to A/T rich DNA sequences. (PubMed id 10523845)9 Deka J....MA1ller O. (Oncogene 1999)
    746. Notable intrafamilial phenotypic variability in a kindred with familial adenomatous polyposis and an APC mutation in exon 9. (PubMed id 10562580)9 Rozen P....Legum C. (Gut 1999)
    747. The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer. (PubMed id 10590231)9 Sohn K.J....Kim Y.I. (Carcinogenesis 1999)
    748. Detection of loss of heterozygosity in the APC tumor suppressor gene in nonpapillary renal cell carcinoma by microdissection and polymerase chain reaction. (PubMed id 9228666)9 BAPhm M....RA1bben H. (Urol. Res. 1997)
    749. AOM-induced mouse colon tumors do not express full-length APC protein. (PubMed id 9450492)9 Maltzman T....Ahnen D. (Carcinogenesis 1997)
    750. [APC mutation analysis in sporadic colorectal cancer]. (PubMed id 9387290)9 Huang J....Jin S. (Zhonghua Zhong Liu Za Zhi 1996)
    751. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. (PubMed id 7708772)9 Munemitsu S....Polakis P. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    752. Molecular genetic analysis of exons 1 to 6 of the APC gene in non-polyposis familial colorectal cancer. (PubMed id 8835324)9 Joyce J.A....Maher E.R. (Clin. Genet. 1995)
    753. The genetic background of familial adenomatous polyposis. Linkage analysis, the APC gene identification and mutation screening. (PubMed id 8776001)9 Kartheuser A....Burn J. (Acta Gastroenterol. Belg. 1995)
    754. Germ-line and somatic mutations of the APC gene in patients with Turcot syndrome and analysis of APC mutations in brain tumors. (PubMed id 7515658)9 Mori T....Ushio Y. (amp 1994)
    755. Insulin receptor function and glycogen synthase activity in human skeletal muscle. Physiology and pathophysiology. (PubMed id 8039433)9 Bak J.F. (Dan Med Bull 1994)
    756. Somatic allelic loss at the DCC, APC, nm23-H1 and p53 tumor suppressor gene loci in human prostatic carcinoma. (PubMed id 7510345)9 Brewster S.F....Brown K.W. (J. Urol. 1994)
    757. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. (PubMed id 7806582)9 Huelsken J.... Behrens J. (J. Cell Biol. 1994)
    758. The amino terminus of ADP-ribosylation factor (ARF) 1 is essential for interaction with Gs and ARF GTPase-activating protein. (PubMed id 7961931)9 Randazzo P.A....Kahn R.A. (J. Biol. Chem. 1994)
    759. Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus. (PubMed id 8514849)9 Vestergaard H....Pedersen O. (J. Clin. Invest. 1993)
    760. Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. (PubMed id 1565631)9 Boynton R.F....Meltzer S.J. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    761. Cell cycle regulators, APC/beta-catenin, NF-kappaB and Epstein-Barr virus in gastric carcinomas. (PubMed id 20025482)9 Kim B....Chang M.S. (Pathology 2010)
    762. Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans. (PubMed id 19190129)9 Kumar K....Ashktorab H. (Clin. Cancer Res. 2009)
    763. An investigation of WNT pathway activation and association with survival in central nervous system primitive neuroectodermal tumours (CNS PNET). (PubMed id 19293793)9 Rogers H.A....Grundy R.G. (Br. J. Cancer 2009)
    764. Mutations in the AXIN1 gene in advanced prostate cancer. (PubMed id 18514389)9 Yardy G.W....Bodmer W.F. (Eur. Urol. 2009)
    765. Methylation of CpG island promoters in uveal melanoma. (PubMed id 18211945)9 Moulin A.P....Benhattar J. (Br J Ophthalmol 2008)
    766. Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis. (PubMed id 18172251)9 Kukitsu T....Niitsu Y. (Clin. Cancer Res. 2008)
    767. Mutational analysis of Wnt signaling molecules in ameloblastoma with aberrant nuclear expression of beta-catenin. (PubMed id 18284543)9 Tanahashi J....Yokoyama S. (amp 2008)
    768. The Wnt-signaling pathway is not implicated in tumorigenesis of Merkel cell carcinoma. (PubMed id 17214850)9 Liu S....Yokoyama S. (J. Cutan. Pathol. 2007)
    769. Alpha-catenin is essential in intestinal adenoma formation. (PubMed id 17989230)9 Shibata H....Noda T. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    770. Inactivation of Apc in the mouse prostate causes prostate carcinoma. (PubMed id 17363566)9 Bruxvoort K.J....Williams B.O. (Cancer Res. 2007)
    771. Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. (PubMed id 17509026)9 Perri F....Andriulli A. (Am. J. Gastroenterol. 2007)
    772. Oligonucleotide DNA chips are useful adjuncts in epigenetic studies of glioblastomas. (PubMed id 17080717)9 Kim B....Park S.H. (Neuropathology 2006)
    773. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. (PubMed id 17030180)9 Janssen K.P....Robine S. (Gastroenterology 2006)
    774. Wnt signaling: is the party in the nucleus? (PubMed id 16751178)9 Willert K. and Jones K.A. (amp 2006)
    775. Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk. (PubMed id 15671542)9 Lewis C.M....Euhus D.M. (Clin. Cancer Res. 2005)
    776. Mutations in Apc and p53 synergize to promote mammary neoplasia. (PubMed id 15695381)9 MAcniel V....Clarke A.R. (Cancer Res. 2005)
    777. Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer. (PubMed id 15942635)9 Leung W.K....Sung J.J. (Br. J. Cancer 2005)
    778. beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. (PubMed id 16258095)9 Ellison D.W....Clifford S.C. (J. Clin. Oncol. 2005)
    779. Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines. (PubMed id 15154912)9 El-Bahrawy M....Tomlinson I.T. (Int J Exp Pathol 2004)
    780. Nuclear accumulation of beta-catenin without an additional somatic mutation in coding region of the APC gene in hepatoblastoma from a familial adenomatous polyposis patient. (PubMed id 14654913)9 Inukai T....Nakazawa S. (Oncol. Rep. 2004)
    781. Genetic pathways of 'de novo' colorectal carcinomas with reference to fetal-type glycogen phosphorylase positive foci. (PubMed id 12469186)9 Shiomori K....Ogawa M. (Int. J. Oncol. 2003)
    782. Rapidly progressive adenomatous polyposis in a patient with germline mutations in both the APC and MLH1 genes: the worst of two worlds. (PubMed id 12740349)9 Scheenstra R....Kleibeuker J.H. (Gut 2003)
    783. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. (PubMed id 12937151)9 Yang B....Clark D.P. (Am. J. Pathol. 2003)
    784. Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. (PubMed id 14600025)9 Xing Y....Xu W. (amp 2003)
    785. Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise. (PubMed id 11872654)9 Thong F.S....Richter E.A. (Diabetes 2002)
    786. Increased beta-catenin mRNA levels and mutational alterations of the APC and beta-catenin gene are present in intestinal-type gastric cancer. (PubMed id 11756228)9 Ebert M.P....Malfertheiner P. (Carcinogenesis 2002)
    787. Genetic alterations in serrated adenomas: comparison to conventional adenomas and hyperplastic polyps. (PubMed id 11823977)9 Fogt F....Odze R.D. (Hum. Pathol. 2002)
    788. Fibromatosis of the breast and mutations involving the APC/beta-catenin pathway. (PubMed id 11823972)9 Abraham S.C....Wu T.T. (Hum. Pathol. 2002)
    789. Frequent alterations of the beta-catenin and TCF-4 genes, but not of the APC gene, in colon cancers with high-frequency microsatellite instability. (PubMed id 11876551)9 Fukushima H....Imai K. (amp 2001)
    790. Absence of microsatellite instability and germline mutations of E-cadherin, APC and p53 genes in Japanese familial gastric cancer. (PubMed id 11399952)9 Kusano M....Imai K. (Tumour Biol. 2001)
    791. The effects of glucose and the hexosamine biosynthesis pathway on glycogen synthase kinase-3 and other protein kinases that regulate glycogen synthase activity. (PubMed id 10916283)9 Singh L.P. and Crook E.D. (J. Investig. Med. 2000)
    792. [Genome analyses for precancerous lesions in the gastrointestinal tract]. (PubMed id 10740625)9 Sowa M. and Nakata B. (amp 2000)
    793. gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. (PubMed id 10837025)9 Kolligs F.T....Fearon E.R. (amp 2000)
    794. Studies of gene expression and activity of hexokinase, phosphofructokinase and glycogen synthase in human skeletal muscle in states of altered insulin-stimulated glucose metabolism. (PubMed id 10081651)9 Vestergaard H. (Dan Med Bull 1999)
    795. Protein synthesis inhibitor-mediated stability of adenomatous polyposis coli mRNA levels in HCT-116 colon cancer cells. (PubMed id 10339655)9 Jaiswal A.S. and Narayan S. (Int. J. Oncol. 1999)
    796. CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. (PubMed id 10490837)9 da Costa L.T....Kinzler K.W. (Oncogene 1999)
    797. Somatic mutation of the APC gene in thyroid carcinoma associated with familial adenomatous polyposis. (PubMed id 10363573)9 Iwama T....Miyaki M. (Jpn. J. Cancer Res. 1999)
    798. Correlation of histologic morphology and tumor stage with molecular genetic analysis using microdissection in gastric carcinomas. (PubMed id 9990480)9 Sugai T....Itoh C. (Diagn. Mol. Pathol. 1998)
    799. A beta-catenin mutation in a sporadic colorectal tumor of the RER phenotype and absence of beta-catenin germline mutations in FAP patients. (PubMed id 9591632)9 MA1ller O....Hoffmann I. (amp 1998)
    800. Concordance of genetic alterations in poorly differentiated colorectal neuroendocrine carcinomas and associated adenocarcinomas. (PubMed id 9326914)9 Vortmeyer A.O....Zhuang Z. (J. Natl. Cancer Inst. 1997)
    801. The interactions of APC, E-cadherin and beta-catenin in tumour development and progression. (PubMed id 9274521)9 Ilyas M. and Tomlinson I.P. (J. Pathol. 1997)
    802. Abnormalities of the adenomatous polyposis coli gene in human oral squamous-cell carcinoma. (PubMed id 7927873)9 Uzawa K....Sato K. (Int. J. Cancer 1994)
    803. APC and p53 mutations in de novo colorectal adenocarcinomas. (PubMed id 8081386)9 Aoki T....Nakamura Y. (Hum. Mutat. 1994)
    804. The capacity for growth stimulation by TGF beta 1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53 or ras. (PubMed id 7970729)9 Huang F....Friedman E. (Oncogene 1994)
    805. Molecular characterization by array comparative genomic hybridization and DNA sequencing of 194 desmoid tumors. (PubMed id 20232483)9 Salas S....Coindre J.M. (amp 2010)
    806. KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype. (PubMed id 20305537)9 Kim K.M....Odze R.D. (Am. J. Surg. Pathol. 2010)
    807. Report on mutation in exon 15 of the APC gene in a case of brain metastasis. (PubMed id 19711014)9 PeA8ina-Slaus N....CupiA8 H. (J. Neurooncol. 2010)
    808. [Dual-role regulations of canonical Wnt/beta-catenin signaling pathway]. (PubMed id 20396373)9 Liu Y....Zhou C.Y. (Beijing Da Xue Xue Bao 2010)
    809. Could APC gene screening be useful in children with hepatoblastoma? Early onset of adenocarcinoma in a child with familial adenomatous polyposis and hepatoblastoma. (PubMed id 20210251)9 Lazzareschi I....Riccardi R. (Tumori 2009)
    810. Identification of somatic APC mutations in recurrent desmoid tumors in a patient with familial adenomatous polyposis to determine actual recurrence of the original tumor or de novo occurrence. (PubMed id 18704758)9 Iwama T....Ishida H. (Fam. Cancer 2009)
    811. Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus. (PubMed id 19628463)9 Fukuda H....Nakagama H. (J. Biol. Chem. 2009)
    812. Genetic mechanisms in Apc-mediated mammary tumorigenesis. (PubMed id 19197353)9 Kuraguchi M....Kucherlapati R. (PLoS Genet. 2009)
    813. Promoter hypermethylation of tumor-related genes in peritoneal lavage and the prognosis of patients with colorectal cancer. (PubMed id 19384904)9 Kamiyama H....Konishi F. (J Surg Oncol 2009)
    814. Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma. (PubMed id 18497987)9 Sogabe Y....Tokino T. (Int. J. Oncol. 2008)
    815. Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations. (PubMed id 17962810)9 Curia M.C....Battista P. (Mod. Pathol. 2008)
    816. Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. (PubMed id 18542073)9 Belshaw N.J....Johnson I.T. (Br. J. Cancer 2008)
    817. The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells. (PubMed id 18627596)9 de la Roche M....Bienz M. (BMC Cancer 2008)
    818. Loss of membrane localization and aberrant nuclear E-cadherin expression correlates with invasion in pancreatic endocrine tumors. (PubMed id 18300809)9 Chetty R....Asa S.L. (Am. J. Surg. Pathol. 2008)
    819. [Gene methylation patterns in digestive tumors]. (PubMed id 18769787)9 Roa S J.C....GuzmA!n G P. (Rev Med Chil 2008)
    820. [Aberrant methylation of multiple genes and its clinical implication in hepatocellular carcinoma]. (PubMed id 19173828)9 Lou C....Du Z. (Zhonghua Zhong Liu Za Zhi 2008)
    821. Clinicopathologic and molecular features of sporadic microsatellite- and chromosomal-stable colorectal cancers. (PubMed id 18193434)9 Cai G....Cai S. (Int J Colorectal Dis 2008)
    822. [An economic assessment of genetic testing for familial adenomatous polyposis]. (PubMed id 18942899)9 Olry de Labry Lima A....Villegas Portero R. (Rev Esp Enferm Dig 2008)
    823. Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors. (PubMed id 18485221)9 Sunami E....Hoon D.S. (Breast Cancer Res. 2008)
    824. Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma. (PubMed id 18831746)9 Smith E....Drew P.A. (Mol. Cancer 2008)
    825. Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas. (PubMed id 17373666)9 Koch A....Pietsch T. (Int. J. Cancer 2007)
    826. Epigenetic changes in tumor suppressor genes, P15, P16, APC-3 and E-cadherin in body fluid. (PubMed id 18055295)9 Chen M.L....Chang J.G. (Kaohsiung J. Med. Sci. 2007)
    827. Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway. (PubMed id 17971904)9 Blanco D....Montuenga L.M. (Neoplasia 2007)
    828. The modifier of Min 2 (Mom2) locus: embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression. (PubMed id 17387143)9 Baran A.A....Buchberg A.M. (Genome Res. 2007)
    829. Promoter hypermethylation of tumor-related genes in sporadic colorectal cancer in young patients. (PubMed id 18365548)9 Noda H....Konishi F. (amp 2007)
    830. Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population. (PubMed id 17532092)9 Kim D.S....Park J.Y. (Lung Cancer 2007)
    831. Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. (PubMed id 17942902)9 Hinoi T....Fearon E.R. (Cancer Res. 2007)
    832. Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genes. (PubMed id 17636402)9 Weijenberg M.P....van den Brandt P.A. (amp 2007)
    833. Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma. (PubMed id 17968429)9 Nomoto S....Nakao A. (Br. J. Cancer 2007)
    834. Brain tumors in individuals with familial adenomatous polyposis: a cancer registry experience and pooled case report analysis. (PubMed id 17238184)9 Attard T.M....Lynch H.T. (Cancer 2007)
    835. Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa. (PubMed id 17640302)9 Iacopetta B....Kawakami K. (Cancer Sci. 2007)
    836. Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon. (PubMed id 18029487)9 Liu Z....Mason J.B. (J. Nutr. 2007)
    837. Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells. (PubMed id 17160019)9 Aoki K....Taketo M.M. (Oncogene 2007)
    838. Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation. (PubMed id 17455096)9 Salaroli R....Cenacchi G. (Ultrastruct Pathol 2007)
    839. MYH Gene Status in Polish FAP Patients without APC Gene Mutations. (PubMed id 20223003)9 Skrzypczak M....PA8awski A. (Hered Cancer Clin Pract 2006)
    840. Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. (PubMed id 16645205)9 Sugai T....Nakamura S. (J Mol Diagn 2006)
    841. Double frameshift mutations in APC and MSH2 in the same individual. (PubMed id 16676398)9 Soravia C....Hutter P. (Int J Colorectal Dis 2006)
    842. Epigenetic heterogeneity of high-grade prostatic intraepithelial neoplasia: clues for clonal progression in prostate carcinogenesis. (PubMed id 16446401)9 Henrique R....Sidransky D. (Mol. Cancer Res. 2006)
    843. Expression of cadherins and catenins correlates with distinct histologic types of ovarian carcinomas. (PubMed id 16867867)9 SarriA^ D....Palacios J. (Hum. Pathol. 2006)
    844. Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility. (PubMed id 16235243)9 Leslie A....Carey F.A. (amp 2006)
    845. Effect of indomethacin on E-cadherin and beta-catenin expression in HT-29 colon cancer cells. (PubMed id 15963497)9 KapitanoviA8 S....Spaventi R. (Exp. Mol. Pathol. 2006)
    846. Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations. (PubMed id 16804962)9 Yamazaki K....Kusano M. (World J. Gastroenterol. 2006)
    847. [Hereditary forms of colorectal adenomatous polyposis]. (PubMed id 16836001)9 KohoutovA! M....JirA!sek V. (Cas. Lek. Cesk. 2006)
    848. Improved marker combination for detection of de novo genetic variation and aberrant DNA in colorectal neoplasia. (PubMed id 17082247)9 Kann L....Shuber A. (Clin. Chem. 2006)
    849. Oligonucleotide microarray analysis of distinct gene expression patterns in colorectal cancer tissues harboring BRAF and K-ras mutations. (PubMed id 16219636)9 Kim I.J....Park J.G. (Carcinogenesis 2006)
    850. [Hereditary colorectal cancer: Molecular analysis of APC and MLH1 genes]. (PubMed id 17130966)9 Bellolio R F....LA^pez-KAPstner F. (Rev Med Chil 2006)
    851. Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability. (PubMed id 15802015)9 Thorstensen L....Lothe R.A. (Neoplasia 2005)
    852. Promoter hypermethylation profile of ovarian epithelial neoplasms. (PubMed id 16061849)9 Makarla P.B....Schorge J.O. (Clin. Cancer Res. 2005)
    853. [Promoter methylation profile in gastric cancer]. (PubMed id 16163424)9 Roa J.C....Araya J.C. (Rev Med Chil 2005)
    854. Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer. (PubMed id 16181380)9 Leung W.K....Sung J.J. (Am. J. Gastroenterol. 2005)
    855. APC germ-line mutations in southern Spanish patients with familial adenomatous polyposis: genotype-phenotype correlations and identification of eight novel mutations. (PubMed id 15857185)9 GarcA-a-Lozano J.R....NA_A+ez-RoldA!n A. (Genet. Test. 2005)
    856. Methylation analysis of the cell cycle control genes in myelofibrosis with myeloid metaplasia. (PubMed id 15755503)9 Kumagai T....Koeffler H.P. (Leuk. Res. 2005)
    857. Regulation of microtubules by Rho GTPases in migrating cells. (PubMed id 16358406)9 Gundersen G.G....Gomes E.R. (Novartis Found. Symp. 2005)
    858. Alterations and correlations of the components in the Wnt signaling pathway and its target genes in breast cancer. (PubMed id 16273236)9 Ozaki S....Asahara T. (Oncol. Rep. 2005)
    859. Double frameshift mutations in APC and MSH2 in the same individual. (PubMed id 15834612)9 Soravia C....Hutter P. (Int J Colorectal Dis 2005)
    860. New mutations in the APC gene in familial adenomatous polyposis: detection, characterization, and analysis. (PubMed id 16027851)9 Muzaffarova T.A....Karpukhin A.V. (Bull. Exp. Biol. Med. 2005)
    861. Refining molecular analysis in the pathways of colorectal carcinogenesis. (PubMed id 16271343)9 Rowan A....Tomlinson I. (Clin. Gastroenterol. Hepatol. 2005)
    862. Aberrant CpG island methylation in early-onset sporadic gastric carcinoma. (PubMed id 16075282)9 Kim H.C....Chang R. (J. Cancer Res. Clin. Oncol. 2005)
    863. Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects. (PubMed id 16170165)9 Hoque M.O....Sidransky D. (J. Clin. Oncol. 2005)
    864. Chromosomal instability, aneuploidy, and gene mutations in human sporadic colorectal adenomas. (PubMed id 15623940)9 Giaretti W....Prevosto C. (Cell. Oncol. 2004)
    865. Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas. (PubMed id 15366000)9 Isidro G.... Boavida M.G. (Hum. Mutat. 2004)
    866. Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia. (PubMed id 14743506)9 Kang G.H....Hwang K.S. (J. Pathol. 2004)
    867. Frequency and parental origin of de novo APC mutations in familial adenomatous polyposis. (PubMed id 14523376)9 Aretz S....Friedl W. (Eur. J. Hum. Genet. 2004)
    868. Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. (PubMed id 15447999)9 Takahashi T....Wistuba I.I. (Clin. Cancer Res. 2004)
    869. Alterations of the p16INK4a/p14ARF pathway in clear cell sarcoma. (PubMed id 15298727)9 Takahira T....Tsuneyoshi M. (Cancer Sci. 2004)
    870. Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. (PubMed id 15057748)9 Reeves H.L....Friedman S.L. (Gastroenterology 2004)
    871. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. (PubMed id 14743218)9 Song M.S....Lim D.-S. (Nat. Cell Biol. 2004)
    872. High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform. (PubMed id 15251969)9 Lilleberg S.L....Culver K. (Ann. N. Y. Acad. Sci. 2004)
    873. High frequency of MYH gene mutations in a subset of patients with familial adenomatous polyposis. (PubMed id 15188161)9 Venesio T....Ranzani G.N. (Gastroenterology 2004)
    874. Analysis of molecular pathways in neuroendocrine cancers of the gastroenteropancreatic system. (PubMed id 15153437)9 Arnold C.N....Blum H.E. (Ann. N. Y. Acad. Sci. 2004)
    875. A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. (PubMed id 15476557)9 Lind G.E....Lothe R.A. (Mol. Cancer 2004)
    876. Comprehensive genetic and endoscopic evaluation may be necessary to distinguish sporadic versus familial adenomatous polyposis-associated abdominal desmoid tumors. (PubMed id 15179376)9 Bandipalliam P....Syngal S. (Surgery 2004)
    877. Detecting cervical cancer by quantitative promoter hypermethylation assay on cervical scrapings: a feasibility study. (PubMed id 15192122)9 Reesink-Peters N....van der Zee A.G. (Mol. Cancer Res. 2004)
    878. Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features. (PubMed id 14719065)9 Lin S.Y....Chang J.G. (Oncol. Rep. 2004)
    879. Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia. (PubMed id 15201966)9 Matsushita C....Taguchi H. (Oncol. Rep. 2004)
    880. Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. (PubMed id 15386372)9 Bai A.H....Leung W.K. (Int. J. Cancer 2004)
    881. Identification of APC gene mutations in colorectal cancer using universal microarray-based combinatorial sequencing-by-hybridization. (PubMed id 15300853)9 Cowie S....Fortina P. (Hum. Mutat. 2004)
    882. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. (PubMed id 14551908)9 Lee E....Kirschner M.W. (PLoS Biol. 2003)
    883. Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior. (PubMed id 14675710)9 House M.G....Brock M.V. (J. Gastrointest. Surg. 2003)
    884. Profile of aberrant CpG island methylation along multistep gastric carcinogenesis. (PubMed id 12695555)9 Kang G.H....Jung H.Y. ( a journal of technical methods and pathology 2003)
    885. Colon cancer-associated DNA mutations: marker selection for the detection of proximal colon cancer. (PubMed id 14639104)9 Berger B.M....Glickman J. (Diagn. Mol. Pathol. 2003)
    886. Reconstructed beta-catenin/TCF4 signaling in yeast applicable to functional evaluation of APC mutations. (PubMed id 14633595)9 Yamada H....Katoh H. (Am. J. Pathol. 2003)
    887. Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. (PubMed id 12663524)9 Yang K....Lipkin M. (Carcinogenesis 2003)
    888. Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice. (PubMed id 12893427)9 Huang H....Ohgaki H. (Cancer Lett. 2003)
    889. APC, beta-Catenin and hTCF-4; an unholy trinity in the genesis of colorectal cancer. (PubMed id 12633551)9 Bright-Thomas R.M. and Hargest R. (Eur J Surg Oncol 2003)
    890. Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. (PubMed id 12584168)9 Gutierrez L.S....Castellino F.J. (Carcinogenesis 2003)
    891. Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. (PubMed id 12845670)9 Edamoto Y....Ohgaki H. (Int. J. Cancer 2003)
    892. Genetic alterations of the APC gene in familial adenomatous polyposis patients of the hellenic group for the study of colorectal cancer. (PubMed id 12894596)9 Mihalatos M....Nasioulas G. (Anticancer Res. 2003)
    893. Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profiles of seminoma and nonseminoma testicular germ cell tumours. (PubMed id 12545168)9 Honorio S....Latif F. (Oncogene 2003)
    894. Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients. (PubMed id 12833148)9 Crabtree M....Tomlinson I.P. (Oncogene 2003)
    895. Tumor formation by genetic mutations in the components of the Wnt signaling pathway. (PubMed id 12824913)9 Kikuchi A. (Cancer Sci. 2003)
    896. Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. (PubMed id 12606733)9 Sieber O.M.... Tomlinson I.P.M. (N. Engl. J. Med. 2003)
    897. Molecular and cellular phenotypic profiles of gastric noninvasive neoplasia. (PubMed id 12480914)9 Jin Z....Motoyama T. ( a journal of technical methods and pathology 2002)
    898. Molecular diagnosis of familial adenomatous polyposis (FAP): genotyping of adenomatous polyposis coli (APC) alleles by MALDI-TOF mass spectrometry. (PubMed id 11983341)9 Bonk T....Becker C.M. (Clin. Biochem. 2002)
    899. Serrated adenoma in familial adenomatous polyposis: relation to germline APC gene mutation. (PubMed id 11839722)9 Matsumoto T....Yao T. (Gut 2002)
    900. Familial adenomatous polyposis associated with multiple endocrine neoplasia type 1-related tumors and thyroid carcinoma: a case report with clinicopathologic and molecular analyses. (PubMed id 11756777)9 Sakai Y....Kato Y. (Am. J. Surg. Pathol. 2002)
    901. Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. (PubMed id 11793365)9 Wong S.C....Wendy Hsiao W.L. (J. Pathol. 2002)
    902. APC gene mutations in a jejunal adenoma causing intussusception in a patient with familial adenomatous polyposis. (PubMed id 12522539)9 Ishida H....Miyaki M. (J. Gastroenterol. 2002)
    903. Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal. (PubMed id 11212250)9 Yang W.C....Augenlicht L.H. (Cancer Res. 2001)
    904. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. (PubMed id 11212243)9 Wetmore C....Curran T. (Cancer Res. 2001)
    905. [Genotyping of multiple genetic alterations of intrahepatic cholangiocarcinoma]. (PubMed id 11798885)9 Cong W....Chen H. (Zhonghua Yi Xue Za Zhi 2001)
    906. Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. (PubMed id 11215281)9 Entius M.M....Offerhaus G.J. (J. Clin. Pathol. 2001)
    907. Infrequent APC mutations in serrated adenoma. (PubMed id 11315765)9 Dehari R. (Tohoku J. Exp. Med. 2001)
    908. Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells. (PubMed id 11481324)9 Oriente F....Beguinot F. (J. Biol. Chem. 2001)
    909. Molecular genetic analysis of appendiceal mucinous adenomas in identical twins, including one with pseudomyxoma peritonei. (PubMed id 11474297)9 Shih I.M....Ronnett B.M. (Am. J. Surg. Pathol. 2001)
    910. APC I1307K and E1317Q variants are rare or do not occur in Swedish colorectal cancer patients. (PubMed id 11267860)9 Evertsson S....Sun X.F. (Eur. J. Cancer 2001)
    911. Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse. (PubMed id 11559569)9 Sohn K.J....Kim Y.I. (Cancer Res. 2001)
    912. Early detection of 2-amino-1-methyl-6-phenylimidazo (4,5-b)pyridine(PhIP)-induced mutations within the Apc gene of rat colon. (PubMed id 11181456)9 Burnouf D....Fuchs R.P. (Carcinogenesis 2001)
    913. [Relationship between genetic alterations and clinicopathological features in intrahepatic cholangiocarcinoma]. (PubMed id 11866974)9 Cong W....Wu M. (Zhonghua Bing Li Xue Za Zhi 2001)
    914. Decreased E-cadherin augments beta-catenin nuclear localization: studies in breast cancer cell lines. (PubMed id 11179484)9 Yang S.Z....Hiwada K. (Int. J. Oncol. 2001)
    915. Differences in carcinogenesis by the length of carcinogen exposure period in rat colon. (PubMed id 11270774)9 Endo T....Sugawara K. (Dig. Dis. Sci. 2001)
    916. Thymic epithelial tumors can develop along two different pathogenetic pathways. (PubMed id 11696445)9 Zhou R....Starostik P. (Am. J. Pathol. 2001)
    917. Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer. (PubMed id 11819821)9 Fang D.C....Luo Y.H. (World J. Gastroenterol. 2001)
    918. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. (PubMed id 10700176)9 Satoh S.... Nakamura Y. (Nat. Genet. 2000)
    919. Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding. (PubMed id 10862053)9 Webster M.T....Wooster R. (amp 2000)
    920. p53 and APC mutations are detectable in the plasma and serum of patients with colorectal cancer (CRC) or adenomas. (PubMed id 10818595)9 Gocke C.D....McGarrity T.J. (Ann. N. Y. Acad. Sci. 2000)
    921. Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer. (PubMed id 10493496)9 Miyaki M....Kuroki T. (Cancer Res. 1999)
    922. Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma. (PubMed id 10212000)9 Kang Y.K....Kim Y.I. ( a journal of technical methods and pathology 1999)
    923. Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma. (PubMed id 10398436)9 Blaeker H.... Otto H.F. (Genes Chromosomes Cancer 1999)
    924. Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. (PubMed id 10096563)9 Edelmann W....Kucherlapati R. (Cancer Res. 1999)
    925. Attenuated familial adenomatous polyposis in a man with an interstitial deletion of chromosome arm 5q. (PubMed id 10494086)9 Pilarski R.T....Shulman Rosengren S. (Am. J. Med. Genet. 1999)
    926. Abnormal expression and function of the E-cadherin-catenin complex in gastric carcinoma cell lines. (PubMed id 10408833)9 Jawhari A.U....Pignatelli M. (Br. J. Cancer 1999)
    927. Colorectal cancer with and without microsatellite instability involves different genes. (PubMed id 10502323)9 Salahshor S....Lindblom A. (amp 1999)
    928. Glycogen depletion rather than glucose 6-P increments controls early glycogen recovery in human cultured muscle. (PubMed id 10233043)9 Montell E....GA^mez-Foix A.M. (Am. J. Physiol. 1999)
    929. The role of the E-cadherin/catenin complex in gastrointestinal cancer. (PubMed id 10692769)9 Debruyne P....Mareel M. (Acta Gastroenterol. Belg. 1999)
    930. Rectal cancer in a 13-year-old boy without a detectable germline mutation in FAP and HNPCC genes. (PubMed id 10433009)9 Kashiwagi H....Kanazawa K. (J. Gastroenterol. 1999)
    931. Establishment and characterization of 12 human colorectal-carcinoma cell lines. (PubMed id 10362137)9 Oh J.H....Park J.G. (Int. J. Cancer 1999)
    932. [Molecular pathology of colorectal cancer]. (PubMed id 10582488)9 Bosman F.T. and Joris F. (Rev Med Suisse Romande 1999)
    933. Frequent p53 gene mutations in serrated adenomas of the colorectum. (PubMed id 9924427)9 Hiyama T....Tahara E. (J. Pathol. 1998)
    934. [Diagnosis of familial adenomatous polyposis based on DNA]. (PubMed id 9919757)9 Mego M. (Bratisl Lek Listy 1998)
    935. Piroxicam and acarbose as chemopreventive agents for spontaneous intestinal adenomas in APC gene 1309 knockout mice. (PubMed id 9617344)9 Quesada C.F....Baba S. (Jpn. J. Cancer Res. 1998)
    936. Absence of somatic alterations of the EB1 gene adenomatous polyposis coli-associated protein in human sporadic colorectal cancers. (PubMed id 9823979)9 JaA^s P....Bressac-de Paillerets B. (Br. J. Cancer 1998)
    937. [Frequency and significance of APC gene mutations in malignant degeneration of Barrett esophagus]. (PubMed id 14518303)9 StAPltzing O....HAPlscher A.H. (Langenbecks Arch Chir Suppl Kongressbd 1998)
    938. Microsatellite instability and loss of heterozygosity at DNA mismatch repair gene loci occurs during hepatic carcinogenesis. (PubMed id 9657101)9 Macdonald G.A....Boland C.R. (Hepatology 1998)
    939. High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. (PubMed id 9515794)9 Dashwood R.H....Nagao M. (Cancer Res. 1998)
    940. Loss of heterozygosity of the von Hippel Lindau gene locus in polypoid dysplasia but not flat dysplasia in ulcerative colitis or sporadic adenomas. (PubMed id 9744312)9 Fogt F....Zhuang Z. (Hum. Pathol. 1998)
    941. EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. (PubMed id 10030671)9 Morrison E.E....Meredith D.M. (Oncogene 1998)
    942. [Tumor suppressor genes with special emphasis on the APC tumor suppressor gene]. (PubMed id 9919881)9 PeA8ina-Slaus N. (Lijec Vjesn 1998)
    943. Comparison of genetic alterations in colonic adenoma and ulcerative colitis-associated dysplasia and carcinoma. (PubMed id 9490271)9 Fogt F....Zhuang Z. (Hum. Pathol. 1998)
    944. N-Acetyl-beta-D-glucopyranosylamine 6-phosphate is a specific inhibitor of glycogen-bound protein phosphatase 1. (PubMed id 9371733)9 Board M. (Biochem. J. 1997)
    945. Abnormal change of p53 gene in gastric and precancerous lesions and APC gene deletion in gastric carcinoma and near tissues. (PubMed id 9639793)9 Hao Y....Qian W. (J. Tongji Med. Univ. 1997)
    946. Stabilization of beta-catenin by genetic defects in melanoma cell lines. (PubMed id 9065403)9 Rubinfeld B....Polakis P. (Science 1997)
    947. Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds. (PubMed id 9341879)9 Walon C....Verellen-Dumoulin C. (Hum. Genet. 1997)
    948. Genetic changes induced by heterocyclic amines. (PubMed id 9202752)9 Nagao M....Sugimura T. (Mutat. Res. 1997)
    949. [Primary hypothyroidism revealing pseudohypoparathyroidism without hypocalcemia and hyperphosphoremia]. (PubMed id 9230993)9 Coutant R....Chaussain J.L. (Arch Pediatr 1997)
    950. [The molecular biology and genetics of colorectal carcinoma]. (PubMed id 9739886)9 Tsancheva M. (Khirurgiia (Sofiia) 1997)
    951. No involvement of APC gene mutations in ulcerative colitis-associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate. (PubMed id 9433483)9 Suzui M....Mori H. (Mol. Carcinog. 1997)
    952. Constitutive APC exon 14 skipping in early-onset familial adenomatous polyposis reveals a dramatic quantitative distortion of APC gene-specific isoforms. (PubMed id 9298819)9 Bala S....Ballhausen W.G. (Hum. Mutat. 1997)
    953. Involvement of the multiple tumor suppressor genes and 12-lipoxygenase in human prostate cancer. Therapeutic implications. (PubMed id 9321930)9 Gao X....Honn K.V. (Adv. Exp. Med. Biol. 1997)
    954. Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma. (PubMed id 9307185)9 Piao Z....Park C. (Cancer 1997)
    955. Allelic imbalance on chromosome 5q predicts long-term survival in neuroblastoma. (PubMed id 8980382)9 Meltzer S.J....Berg P.E. (Br. J. Cancer 1996)
    956. Characterization of the APC gene in sporadic gastric adenocarcinomas. (PubMed id 8649856)9 Powell S.M....Jackson C.E. (Oncogene 1996)
    957. Loss of heterozygosity at the p53, RB, DCC and APC tumor suppressor gene loci in human bladder cancer. (PubMed id 8632608)9 Miyamoto H....Kubota Y. (J. Urol. 1996)
    958. Common deleted region on the long arm of chromosome 5 in esophageal carcinoma. (PubMed id 8536888)9 Ogasawara S....Satodate R. (Gastroenterology 1996)
    959. Correlation between the development of extracolonic manifestations in FAP patients and mutations beyond codon 1403 in the APC gene. (PubMed id 8730280)9 Dobbie Z....Scott R.J. (J. Med. Genet. 1996)
    960. Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes. (PubMed id 8628279)9 Papkoff J....Polakis P. (Mol. Cell. Biol. 1996)
    961. Pancreatic adenocarcinoma: epidemiology and genetics. (PubMed id 8950667)9 Flanders T.Y. and Foulkes W.D. (J. Med. Genet. 1996)
    962. [Relation between loss of heterozygosity at APC and MCC genetic loci and biological behaviour of gastric carcinoma]. (PubMed id 8732100)9 Liu B....Yu W. (Zhonghua Zhong Liu Za Zhi 1996)
    963. Emergent issues in the genetics of intestinal neoplasia. (PubMed id 8718526)9 Dove W.F....Shoemaker A.R. (Cancer Surv. 1995)
    964. Genotype-phenotype correlations of new causative APC gene mutations in patients with familial adenomatous polyposis. (PubMed id 8544194)9 Bunyan D.J....Eccles D.M. (J. Med. Genet. 1995)
    965. [Multiple tumor suppressor genes in esophageal carcinoma induced in human fetus esophageal epithelium by NMBzA]. (PubMed id 7656818)9 Li H....Cui X. (Zhonghua Zhong Liu Za Zhi 1995)
    966. Novel germline APC gene mutation in a large familial adenomatous polyposis kindred displaying variable phenotypes. (PubMed id 7797123)9 Scott R.J....Brazzola P.L. (Gut 1995)
    967. [Correlation studies on the alterations of multiple tumor suppressor genes in human esophageal cancer and in human and monkey esophageal epithelial cells treated with N-methyl-N-benzyl nitrosamine]. (PubMed id 7587888)9 Li H....Cui X. (Zhonghua Zhong Liu Za Zhi 1995)
    968. [Multiple gene alterations involved in the processor of human gastric carcinogenesis]. (PubMed id 8697090)9 Lu Y....Sun M. (Zhonghua Yi Xue Za Zhi 1995)
    969. Exon eight APC mutations account for a disproportionate number of familial adenomatous polyposis families. (PubMed id 8118461)9 Koorey D.J....Gallagher N.D. (Hum. Mutat. 1994)
    970. Frequency of common and novel inactivating APC mutations in 202 families with familial adenomatous polyposis. (PubMed id 8162022)9 Mandl M....Propping P. (Hum. Mol. Genet. 1994)
    971. Loss of Apc+ in intestinal adenomas from Min mice. (PubMed id 7954427)9 Luongo C....Dove W.F. (Cancer Res. 1994)
    972. Aberrations of tumor-suppressor genes (p53, apc, mcc and Rb) in esophageal squamous-cell carcinoma. (PubMed id 8150536)9 Maesawa C....Satodate R. (Int. J. Cancer 1994)
    973. Presymptomatic diagnosis in families with adenomatous polyposis using highly polymorphic dinucleotide CA repeat markers flanking the APC gene. (PubMed id 7915330)9 Eckert W.A....Wolff G. (J. Med. Genet. 1994)
    974. [Genetic alterations of human colorectal cancer]. (PubMed id 8109990)9 Suzuki T....Kanamaru R. (amp 1994)
    975. Exclusion of the APC gene as the cause of a variant form of familial adenomatous polyposis (FAP) (PubMed id 8213830)9 Stella A....Guanti G. (Am. J. Hum. Genet. 1993)
    976. Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients. (PubMed id 8252631)9 Olschwang S....Thomas G. (Cell 1993)
    977. Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP). (PubMed id 8395678)9 Ichii S....Utsunomiya J. (Oncogene 1993)
    978. Molecular diagnosis of familial adenomatous polyposis. (PubMed id 8247073)9 Powell S.M....Kinzler K.W. (N. Engl. J. Med. 1993)
    979. Cell and molecular biology of gastrointestinal tract cancer. (PubMed id 1324739)9 Paraskeva C. and Williams A.C. (Curr Opin Oncol 1992)
    980. Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis. (PubMed id 1324223)9 Fodde R....Khan P.M. (Genomics 1992)
    981. Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. (PubMed id 1316610)9 Miyoshi Y....Petersen G. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    982. Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP). (PubMed id 1338760)9 Ichii S....Nakamura Y. (Hum. Mol. Genet. 1992)
    983. Yeast artificial chromosomes for the molecular analysis of the familial polyposis APC gene region. (PubMed id 1325652)9 Hampton G.M....Frischauf A.M. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    984. Mutations in the alpha subunit of the stimulatory regulatory protein of adenylyl cyclase (Gs) in human GH-secreting pituitary adenomas. Biochemical, clinical, and morphological aspects. (PubMed id 1923949)9 Spada A....Bazzoni N. (Pathol. Res. Pract. 1991)
    985. (PubMed id 17984005)9 
    986. Recent insights into the pathogenesis of colorectal cancer. (PubMed id 19786869)9 Goel A. and Boland C.R. (Curr. Opin. Gastroenterol. 2010)
    987. Gene promoter methylation patterns throughout the process of cervical carcinogenesis. (PubMed id 20208141)9 Yang N....van der Zee A.G. (Cell. Oncol. 2010)
    988. Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice. (PubMed id 20442768)9 Labalette C....Wei Y. (PLoS ONE 2010)
    989. Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposis. (PubMed id 19731080)9 Jasperson K.W....Weitzel J.N. (Fam. Cancer 2010)
    990. Methylated genes as potential biomarkers in prostate cancer. (PubMed id 20067451)9 PhAc V....RouprA-t M. (BJU Int. 2010)
    991. The safety and efficacy of celecoxib in children with familial adenomatous polyposis. (PubMed id 20234350)9 Lynch P.M....Burke C.A. (Am. J. Gastroenterol. 2010)
    992. Establishment and characterization of 13 human colorectal carcinoma cell lines: mutations of genes and expressions of drug-sensitivity genes and cancer stem cell markers. (PubMed id 20176655)9 Ku J.L....Park J.G. (Carcinogenesis 2010)
    993. Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis. (PubMed id 20386734)9 Auburn S....Kwiatkowski D.P. (PLoS ONE 2010)
    994. Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors. (PubMed id 18767147)9 Sweeney C....Slattery M.L. (amp 2009)
    995. Familial adenomatous polyposis. (PubMed id 19414146)9 Macrae F....Nasioulas S. (amp 2009)
    996. Colorectal cancer in South Africa: a heritable cause suspected in many young black patients. (PubMed id 19418671)9 CronjAc L....Becker P.J. (S. Afr. Med. J. 2009)
    997. Multiple neoplasia in a 15-year-old girl with familial adenomatous polyposis. (PubMed id 19564752)9 Brasseur B....Brichard B. (J. Pediatr. Hematol. Oncol. 2009)
    998. Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma. (PubMed id 19336228)9 Ksiaa F....Trimeche M. ( international journal of clinical chemistry 2009)
    999. The role of mTORC1 pathway in intestinal tumorigenesis. (PubMed id 19855161)9 Fujishita T....Taketo M.M. (Cell Cycle 2009)
    1000. Detection of the DNA point mutation of colorectal cancer cells isolated from feces stored under different conditions. (PubMed id 19042945)9 Koga Y....Matsumura Y. (Jpn. J. Clin. Oncol. 2009)
    1001. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. (PubMed id 19101982)9 Cieply B....Monga S.P. (Hepatology 2009)
    1002. Endometrial cancer and somatic G&gt;T KRAS transversion in patients with constitutional MUTYH biallelic mutations. (PubMed id 18980800)9 Tricarico R....Genuardi M. (Cancer Lett. 2009)
    1003. Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science. (PubMed id 19054549)9 Wentzensen N....Wang S.S. (Gynecol. Oncol. 2009)
    1004. [Familial colorectal cancer type X: clinical, pathological and molecular characterization]. (PubMed id 19686620)9 Ferreira S....Nobre LeitALo C. (Acta Med Port 2009)
    1005. Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review). (PubMed id 19578761)9 Kobayashi H....Oi H. (Oncol. Rep. 2009)
    1006. Modeling using baseline characteristics in a small multicenter clinical trial for Barrett's esophagus. (PubMed id 19013259)9 Shar A.O....Sontag S.J. (Contemp Clin Trials 2009)
    1007. Germline variants of the promyelocytic leukemia tumor suppressor gene in patients with familial cancer. (PubMed id 19728758)9 Plevova P....Silhanova E. (Neoplasma 2009)
    1008. Use of Comet-FISH in the study of DNA damage and repair: review. (PubMed id 18304859)9 Glei M....Pool-Zobel B.L. (Mutat. Res. 2009)
    1009. Study designs in genetic epidemiology. (PubMed id 19381960)9 Cote M.L. (Methods Mol. Biol. 2009)
    1010. A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. (PubMed id 19924305)9 Finlayson A.E. and Freeman K.W. (PLoS ONE 2009)
    1011. Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies. (PubMed id 18987168)9 Smallridge R.C....Copland J.A. (Endocr. Relat. Cancer 2009)
    1012. Effects of Helicobacter pylori infection on genetic instability, the aberrant CpG island methylation status and the cellular phenotype in Barrett's esophagus in a Japanese population. (PubMed id 19048617)9 Moriichi K....Kohgo Y. (Int. J. Cancer 2009)
    1013. Clinical, pathologic, and molecular features of early-onset colorectal carcinoma. (PubMed id 19047896)9 Yantiss R.K....Chen Y.T. (Am. J. Surg. Pathol. 2009)
    1014. The effect of disease-associated HRPT2 mutations on splicing. (PubMed id 19332451)9 Hahn M.A....Marsh D.J. (J. Endocrinol. 2009)
    1015. Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor. (PubMed id 19637320)9 Chen T.T....Tomlinson G.E. (amp 2009)
    1016. Metastatic leiomyosarcoma in the oral cavity: case report with protein expression profiles. (PubMed id 19664933)9 Kim S.M....Lee J.H. (J Craniomaxillofac Surg 2009)
    1017. Targeting the WNT/beta-catenin/TCF/LEF1 axis in solid and haematological cancers: Multiplicity of therapeutic options. (PubMed id 19729298)9 Gehrke I....Kreuzer K.A. (Eur. J. Cancer 2009)
    1018. Genetic pathways to colorectal cancer. (PubMed id 19576232)9 Lea I.A....Dunnick J.K. (Mutat. Res. 2009)
    1019. G-protein and signalling in pituitary tumours. (PubMed id 19407505)9 Lania A. and Spada A. (Horm. Res. 2009)
    1020. Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations. (PubMed id 19755659)9 Itano O....Lipkin M. (Carcinogenesis 2009)
    1021. Control of liver glycogen synthase activity and intracellular distribution by phosphorylation. (PubMed id 19124463)9 Ros S....Guinovart J.J. (J. Biol. Chem. 2009)
    1022. Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer. (PubMed id 19691111)9 Camps J....Difilippantonio M.J. (amp 2009)
    1023. Methylation profiles of 22 candidate genes in breast cancer using high-throughput MALDI-TOF mass array. (PubMed id 19503099)9 Radpour R....Zhong X.Y. (Oncogene 2009)
    1024. The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background. (PubMed id 18723878)9 Halberg R.B....Dove W.F. (Genetics 2008)
    1025. Post exercise carbohydrate-protein supplementation: phosphorylation of muscle proteins involved in glycogen synthesis and protein translation. (PubMed id 18163180)9 Ivy J.L....Morrison P.J. (Amino Acids 2008)
    1026. Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. (PubMed id 18048385)9 Derks S....van Engeland M. (Carcinogenesis 2008)
    1027. Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. (PubMed id 18716166)9 Yang K....Lipkin M. (J. Nutr. 2008)
    1028. Lack of involvement of the GNAS1 T393C polymorphism in prostate cancer risk in a Japanese population. (PubMed id 19189654)9 Watanabe M....Shiraishi T. (Anticancer Res. 2008)
    1029. Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast. (PubMed id 18593979)9 Hayes M.J....Kleer C.G. (Clin. Cancer Res. 2008)
    1030. Importance of Wnt signaling in the tumor stroma microenvironment. (PubMed id 18781892)9 Macheda M.L. and Stacker S.A. (Curr Cancer Drug Targets 2008)
    1031. Wnt signaling in renal cancer. (PubMed id 18673245)9 GuillAcn-Ahlers H. (Curr Drug Targets 2008)
    1032. A role for iron in Wnt signalling. (PubMed id 17700530)9 Brookes M.J....Tselepis C. (Oncogene 2008)
    1033. Methylation of tumor associated genes in tissue and plasma samples from liver disease patients. (PubMed id 18691570)9 Chang H....Cao Y. (Exp. Mol. Pathol. 2008)
    1034. Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruption. (PubMed id 18372912)9 Wang X....Ling M.T. (Oncogene 2008)
    1035. Culture of primary epithelial adenoma cells from familial adenomatous polyposis patients. (PubMed id 18507027)9 Fostira F....Nasioulas G. (Anticancer Res. 2008)
    1036. Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray. (PubMed id 18286531)9 Wang Y....Lu Z. (Cancer 2008)
    1037. Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice. (PubMed id 18204079)9 Oyama T....Mori H. (Carcinogenesis 2008)
    1038. Total number of genome alterations in sporadic gastrointestinal cancer inferred from pooled analyses in the literature. (PubMed id 19023234)9 Nishimura T. (Tumour Biol. 2008)
    1039. One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis. (PubMed id 18794146)9 Yeung A.T....Knudson A. (Cancer Res. 2008)
    1040. [Dentistry anomalies in patients with Lynch syndrome and familial adenomatous polyposis]. (PubMed id 19127816)9 BudzyA8ska A. (Ann Acad Med Stetin 2008)
    1041. The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. (PubMed id 18952824)9 GonAsalves V....Jordan P. (RNA 2008)
    1042. Epigenetic signatures of familial cancer are characteristic of tumor type and family category. (PubMed id 18559504)9 Joensuu E.I....PeltomAoki P. (Cancer Res. 2008)
    1043. AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade. (PubMed id 17945190)9 Wang H.M....Mehta K.D. (Biochem. Pharmacol. 2008)
    1044. The formin mDia2 stabilizes microtubules independently of its actin nucleation activity. (PubMed id 18458159)9 Bartolini F....Gundersen G.G. (J. Cell Biol. 2008)
    1045. Functional coupling of Gs and CFTR is independent of their association with lipid rafts in epithelial cells. (PubMed id 18224335)9 Wang D....Huang P. (Pflugers Arch. 2008)
    1046. Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. (PubMed id 19169048)9 Ruggeri R.M....CannavA^ S. (J. Endocrinol. Invest. 2008)
    1047. Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. (PubMed id 18283316)9 Suzuki H....Tokino T. (Br. J. Cancer 2008)
    1048. Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling. (PubMed id 18627528)9 Liu S....Riker A.I. (amp 2008)
    1049. Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation. (PubMed id 18519763)9 Suehiro Y....Hinoda Y. (Clin. Cancer Res. 2008)
    1050. Reprimo as a potential biomarker for early detection in gastric cancer. (PubMed id 18829507)9 Bernal C....Corvalan A.H. (Clin. Cancer Res. 2008)
    1051. Colorectal cancer is a paracrine deficiency syndrome amenable to oral hormone replacement therapy. (PubMed id 19727435)9 Li P....Waldman S.A. (Clin Transl Sci 2008)
    1052. [Genetic abnormalities of digestive tract adenocarcinomas and correlation with the histologic sequence of their development]. (PubMed id 18674502)9 SA!nchez-Fayos Calabuig P....Porres Cubero J.C. (Med Clin (Barc) 2008)
    1053. First genetic analysis in Tunisian familial adenomatous polyposis probands. (PubMed id 18425378)9 Bougatef K....Soubrier F. (Oncol. Rep. 2008)
    1054. Identification of mucin depleted foci in the human colon. (PubMed id 19139006)9 Femia A.P....Caderni G. (Cancer Prev Res (Phila) 2008)
    1055. Follicular thyroid carcinoma with an unusual glomeruloid pattern of growth. (PubMed id 18602667)9 Cameselle-Teijeiro J....Sobrinho-SimA/es M. (Hum. Pathol. 2008)
    1056. Apc mice: models, modifiers and mutants. (PubMed id 18538487)9 McCart A.E....Silver A. (Pathol. Res. Pract. 2008)
    1057. Frizzled-7 as a potential therapeutic target in colorectal cancer. (PubMed id 18592008)9 Ueno K....Hinoda Y. (Neoplasia 2008)
    1058. Germ-line and somatic mutations of the APC gene and/or ss catenin gene in the occurrence of FAP associated thyroid carcinoma. (PubMed id 17426899)9 Cetta F....Barellini L. (World J Surg 2007)
    1059. The many ways of Wnt in cancer. (PubMed id 17208432)9 Polakis P. (amp 2007)
    1060. Cigarette smoke condensate-induced level of adenomatous polyposis coli blocks long-patch base excision repair in breast epithelial cells. (PubMed id 16924228)9 Kundu C.N....Narayan S. (Oncogene 2007)
    1061. Frequent mutation of Apc gene in rat colon tumors and mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis. (PubMed id 17234750)9 Femia A.P....Caderni G. (Cancer Res. 2007)
    1062. Feasibility of double-balloon enteroscopy-assisted chromoendoscopy of the small bowel in patients with familial adenomatous polyposis. (PubMed id 17252461)9 MAPnkemA1ller K....Malfertheiner P. (Endoscopy 2007)
    1063. [Colorectal carcinogenesis. 1. Hereditary predisposition and colorectal cancer]. (PubMed id 17369756)9 Karoui M....Penna C. (J Chir (Paris) 2007)
    1064. Promoter hypermethylation identifies progression risk in bladder cancer. (PubMed id 17404085)9 Yates D.R....Catto J.W. (Clin. Cancer Res. 2007)
    1065. R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells. (PubMed id 17275129)9 Behari J....Monga S.P. (J. Hepatol. 2007)
    1066. Genetic changes in Slovenian patients with gastric adenocarcinoma evaluated in terms of microsatellite DNA. (PubMed id 17998833)9 Gazvoda B....Komel R. (amp 2007)
    1067. The effects of nucleoside analogues on promoter methylation of selected tumor suppressor genes in MCF-7 and MDA-MB-231 breast cancer cell lines. (PubMed id 18058533)9 Krawczyk B....Fabianowska-Majewska K. (amp 2007)
    1068. Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa. (PubMed id 16785283)9 Ishii T....Matsubara N. (Gut 2007)
    1069. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. (PubMed id 17087942)9 Goel A....Boland C.R. (Gastroenterology 2007)
    1070. G protein betagamma subunits interact with alphabeta- and gamma-tubulin and play a role in microtubule assembly in PC12 cells. (PubMed id 17705289)9 Montoya V....Roychowdhury S. (Cell Motil. Cytoskeleton 2007)
    1071. X radiation up-regulates the occurrence and the multiplicity of invasive carcinomas in the intestinal tract of Apc(min/+) mice. (PubMed id 17903035)9 Nakayama T....Sekine I. (Radiat. Res. 2007)
    1072. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. (PubMed id 17418409)9 Wu R....Cho K.R. (Cancer Cell 2007)
    1073. Epigenetic markers for molecular detection of prostate cancer. (PubMed id 17325424)9 Costa V.L....JerA^nimo C. (Dis. Markers 2007)
    1074. MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis. (PubMed id 17638869)9 Sakamoto K....Tsuzuki T. (Cancer Res. 2007)
    1075. [Promoter methylation of several tumor suppressor genes in human gastric adenocarcinoma]. (PubMed id 17650424)9 Cai J.C....Xia N.S. (Zhonghua Yi Xue Za Zhi 2007)
    1076. Genetics, clinical manifestations and management of FAP and HNPCC. (PubMed id 18298004)9 Pavlovic-Calic N....Iljazovic S. (Med Arh 2007)
    1077. Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. (PubMed id 17882284)9 Chim C.S....Liang R. (Leukemia 2007)
    1078. Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. (PubMed id 17378912)9 Leung W.K....Sung J.J. (Am. J. Gastroenterol. 2007)
    1079. Hypermethylation of the COX-2 gene is a potential prognostic marker for cervical cancer. (PubMed id 17578348)9 Jo H....Lee H.P. (J. Obstet. Gynaecol. Res. 2007)
    1080. [Frequent promoter hypermethylation of several tumor suppressor genes in gastric carcinoma and foveolar epithelium]. (PubMed id 18069630)9 Cai J.C....Xia N.S. (Zhonghua Zhong Liu Za Zhi 2007)
    1081. Analysis of molecular pathways in sporadic neuroendocrine tumors of the gastro-entero-pancreatic system. (PubMed id 17278096)9 Arnold C.N....Blum H.E. (Int. J. Cancer 2007)
    1082. Genetic testing in colorectal cancer: who, when, how and why. (PubMed id 17392593)9 Davidson N.O. (Keio J Med 2007)
    1083. Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. (PubMed id 17897439)9 Schlange T....Hynes N.E. (Breast Cancer Res. 2007)
    1084. Gs alpha overexpression and loss of Gs alpha imprinting in human somatotroph adenomas: association with tumor size and response to pharmacologic treatment. (PubMed id 17514647)9 Picard C....Barlier A. (Int. J. Cancer 2007)
    1085. [Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes]. (PubMed id 17369979)9 Zavala G L....CorvalA!n R A. (Rev Med Chil 2007)
    1086. The patient with multiple intestinal polyps. (PubMed id 17544108)9 Schulmann K....Schmiegel W. (amp 2007)
    1087. Molecular prognostic factors in adenocarcinoma of the esophagus and gastroesophageal junction. (PubMed id 17122988)9 Lagarde S.M....van Lanschot J.J. (Ann. Surg. Oncol. 2007)
    1088. Colorectal cancer: potential therapeutic benefits of Vitamin D. (PubMed id 17157547)9 JimAcnez-Lara A.M. (amp 2007)
    1089. CD44-positive colorectal adenoma cells express the potential stem cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2). (PubMed id 17708598)9 Schulenburg A....Ulrich-Pur H. (J. Pathol. 2007)
    1090. Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. (PubMed id 17534895)9 Shi Y....Jablons D.M. (Int. J. Cancer 2007)
    1091. WNT signaling pathway and stem cell signaling network. (PubMed id 17634527)9 Katoh M. and Katoh M. (Clin. Cancer Res. 2007)
    1092. 17p13 (p53 locus), 5q21 (APC locus) and 9p21 (p16 locus) allelic deletions are frequently found in oral exfoliative cytology cells from smoker patients with non-small-cell lung cancer. (PubMed id 17330809)9 Sanz-Ortega J....Callol L. (Histol. Histopathol. 2007)
    1093. Deletion mutation of BRAF in a serrated adenoma from a patient with familial adenomatous polyposis. (PubMed id 17696956)9 Lee E.J....Kim K.M. (APMIS 2007)
    1094. Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach. (PubMed id 17262083)9 Tajima Y....Kusano M. (Br. J. Cancer 2007)
    1095. Hypermethylation of CpG island loci and hypomethylation of LINE-1 and Alu repeats in prostate adenocarcinoma and their relationship to clinicopathological features. (PubMed id 17139617)9 Cho N.Y....Kang G.H. (J. Pathol. 2007)
    1096. Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. (PubMed id 17513702)9 FrA...Wojtaszewski J.F. (Diabetes 2007)
    1097. Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways. (PubMed id 17908962)9 SA!nchez-de-Abajo A....Caldes T. (Clin. Cancer Res. 2007)
    1098. [Mechanism of Wnt signaling pathway regulation by a truncated mutant of Axin2 in colorectal cancer]. (PubMed id 17927870)9 Wang F.W....Ma G. (Ai Zheng 2007)
    1099. Massive infiltration of bone marrow in colon carcinoma after treatment with activated protein C. (PubMed id 17492354)9 Pleyer L....Greil R. (Wien. Klin. Wochenschr. 2007)
    1100. Role of glycogen content in insulin resistance in human muscle cells. (PubMed id 17167773)9 Litherland G.J....Yeaman S.J. (J. Cell. Physiol. 2007)
    1101. Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns. (PubMed id 17693665)9 Lea I.A....Dunnick J.K. (Carcinogenesis 2007)
    1102. Combinatorial prevention of carcinogenic risk in a model for familial colon cancer. (PubMed id 17342335)9 Telang N. and Katdare M. (Oncol. Rep. 2007)
    1103. Epigenetic changes (aberrant DNA methylation) in colorectal neoplasia. (PubMed id 20485652)9 Kim Y.S. and Deng G. (Gut Liver 2007)
    1104. Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy. (PubMed id 16956712)9 Bastian P.J....von RA1cker A. (Eur. Urol. 2007)
    1105. Hereditary cancer syndromes. (PubMed id 17935271)9 Fostira F....Yannoukakos D. (J BUON 2007)
    1106. Atypia and DNA methylation in nipple duct lavage in relation to predicted breast cancer risk. (PubMed id 17855699)9 Euhus D.M....Lewis C.M. (amp 2007)
    1107. DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. (PubMed id 17623056)9 Wu Q....Lind G.E. (Mol. Cancer 2007)
    1108. Methylation of multiple genes as diagnostic and therapeutic markers in primary head and neck squamous cell carcinoma. (PubMed id 18025318)9 Chen K....Worsham M.J. (amp 2007)
    1109. [Stem cell theory of colorectal cancer and its connection with molecular-biological data]. (PubMed id 17452307)9 HagymA!si K....Tulassay Z. (Orv Hetil 2007)
    1110. Turcot syndrome confirmed with molecular analysis. (PubMed id 17389002)9 Lebrun C....Frenay M. (Eur. J. Neurol. 2007)
    1111. Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy. (PubMed id 17601993)9 Lindegaard B....Pedersen B.K. (Diabetes 2007)
    1112. Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. (PubMed id 17258725)9 Will O....Tomlinson I. (Gastroenterology 2007)
    1113. Natural flavonoids are potent inhibitors of glycogen phosphorylase. (PubMed id 16317787)9 Jakobs S....Eisenbrand G. (amp 2006)
    1114. Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells. (PubMed id 17020613)9 Fuerer C....Iggo R.D. (BMC Cancer 2006)
    1115. Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients. (PubMed id 17108212)9 Taback B....Hoon D.S. (Ann. N. Y. Acad. Sci. 2006)
    1116. Methylation of APC, TIMP3, and TERT: a new predictive marker to distinguish Barrett's oesophagus patients at risk for malignant transformation. (PubMed id 16278815)9 ClAcment G....Benhattar J. (J. Pathol. 2006)
    1117. [Familial adenomatous polyposis: Gardner's syndrome]. (PubMed id 16846135)9 NA_A+ez NA_A+ez R....SantamarA-a Ossorio J.I. (Cir Pediatr 2006)
    1118. Celecoxib: new indication. Colorectal cancer: no preventive benefit. (PubMed id 16548099)9 (Prescrire Int 2006)
    1119. 7,12-Dimethylbenzanthracene-dependent transcriptional regulation of adenomatous polyposis coli (APC) gene expression in normal breast epithelial cells is mediated by GC-box binding protein Sp3. (PubMed id 16150893)9 Jaiswal A.S....Narayan S. (Carcinogenesis 2006)
    1120. Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer. (PubMed id 16482617)9 Tamura G. (World J. Gastroenterol. 2006)
    1121. Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas. (PubMed id 16902913)9 Judson H....Carey F.A. (J. Pathol. 2006)
    1122. Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data. (PubMed id 16928264)9 Yang H.J....Ngan H.Y. (BMC Cancer 2006)
    1123. A novel exon duplication event leading to a truncating germ-line mutation of the APC gene in a familial adenomatous polyposis family. (PubMed id 16736293)9 McCart A....Silver A. (Fam. Cancer 2006)
    1124. Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. (PubMed id 16709231)9 You S....Hrushesky W.J. (Int J Exp Pathol 2006)
    1125. Epigenetic events of disease progression in head and neck squamous cell carcinoma. (PubMed id 16785414)9 Worsham M.J....Benninger M.S. (amp 2006)
    1126. Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma. (PubMed id 16331610)9 Kang S....Lee H.P. (Int. J. Cancer 2006)
    1127. Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis. (PubMed id 16941501)9 Lejeune S....Buisine M.P. (Hum. Mutat. 2006)
    1128. DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. (PubMed id 16421593)9 Kawakami K....Iacopetta B. (Br. J. Cancer 2006)
    1129. Detection of stool DNA mutations before and after treatment of colorectal neoplasia. (PubMed id 16342248)9 Syngal S....Ross M. (Cancer 2006)
    1130. Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. (PubMed id 16369045)9 Cheng Y.W....Barany F. (Genome Res. 2006)
    1131. Promoter methylation precedes chromosomal alterations in colorectal cancer development. (PubMed id 17167178)9 Derks S....van Engeland M. (Cell. Oncol. 2006)
    1132. Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli. (PubMed id 17049664)9 Jeannot E....Zucman-Rossi J. (J. Hepatol. 2006)
    1133. Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations? (PubMed id 16317745)9 Aretz S....Pietsch T. (amp 2006)
    1134. Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. (PubMed id 17030191)9 Chan D.W....Ng I.O. (Gastroenterology 2006)
    1135. Alteration of DNA methylation status in K562 and MCF-7 cancer cell lines by nucleoside analogues. (PubMed id 17065059)9 Krawczyk B. and Fabianowska-Majewska K. (amp 2006)
    1136. Heritable differences in the dopaminergic regulation of behavior in rats: relationship to D2-like receptor G-protein function. (PubMed id 16123742)9 Swerdlow N.R....Hammer R.P. (Neuropsychopharmacology 2006)
    1137. Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung. (PubMed id 16991125)9 Tang M....Sanchez-Cespedes M. (Int. J. Cancer 2006)
    1138. Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers. (PubMed id 16452191)9 Toyooka S....Shimizu N. (Cancer Res. 2006)
    1139. Redundant expression of canonical Wnt ligands in human breast cancer cell lines. (PubMed id 16465433)9 Benhaj K....Ozturk M. (Oncol. Rep. 2006)
    1140. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. (PubMed id 16537562)9 Peng D.F....Hirohashi S. (Carcinogenesis 2006)
    1141. Current issues with beta2-adrenoceptor agonists: pharmacology and molecular and cellular mechanisms. (PubMed id 17085788)9 Anderson G.P. (amp 2006)
    1142. Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma. (PubMed id 16149064)9 Langdon J.A....Clifford S.C. (amp 2006)
    1143. [Genetics in neurocardiogenic syncope]. (PubMed id 17642146)9 Lelonek M. (Prz. Lek. 2006)
    1144. Genetic predisposition to colorectal cancer: new pieces in the pediatric puzzle. (PubMed id 16819371)9 Durno C.A. and Gallinger S. (J. Pediatr. Gastroenterol. Nutr. 2006)
    1145. Molecular biology in colorectal cancer. (PubMed id 16790391)9 Benito M. and DA-az-Rubio E. (amp 2006)
    1146. Cancer genetics: colorectal cancer as a model. (PubMed id 16596323)9 Bodmer W.F. (J. Hum. Genet. 2006)
    1147. Genetics of colorectal cancer. (PubMed id 16629258)9 Jeter J.M....Gruber S.B. (Oncology (Williston Park, N.Y.) 2006)
    1148. Expression of endometrial glycogen synthase kinase-3beta protein throughout the menstrual cycle and its regulation by progesterone. (PubMed id 16882987)9 Salameh W....Khorram O. (Mol. Hum. Reprod. 2006)
    1149. Effective treatment of tumors with strong beta-catenin/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector. (PubMed id 17047077)9 Kuroda T....Martuza R.L. (Cancer Res. 2006)
    1150. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. (PubMed id 17047044)9 MuA+oz N.M....Grady W.M. (Cancer Res. 2006)
    1151. [Genetic factors and colorectal cancers development: therapeutic impact]. (PubMed id 16705943)9 Olschwang S....Bertucci F. (Med Sci (Paris) 2006)
    1152. [Current concepts in the genetics of hereditary and sporadic colorectal cancer and the role of genetics in patient management. Hereditary colorectal cancers]. (PubMed id 16579336)9 Lakatos P.L. and Lakatos L. (Orv Hetil 2006)
    1153. Microdissection-based allelotyping: a novel technique to determine the temporal sequence and biological aggressiveness of colorectal cancer. (PubMed id 16719202)9 Gamblin T.C....Blumberg D. (Am Surg 2006)
    1154. Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients. (PubMed id 17108214)9 Taback B....Hoon D.S. (Ann. N. Y. Acad. Sci. 2006)
    1155. Epigenetic instability and chromosomal instability in hepatocellular carcinoma. (PubMed id 16565510)9 Katoh H....Hirohashi S. (Am. J. Pathol. 2006)
    1156. Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. (PubMed id 16299030)9 Akiyoshi T....Katano M. (Gut 2006)
    1157. Genetics of pseudohypoparathyroidism types Ia and Ic. (PubMed id 16789628)9 Aldred M.A. (amp 2006)
    1158. Mechanisms of disease: adrenocortical tumors--molecular advances and clinical perspectives. (PubMed id 17082810)9 Bertherat J....Bertagna X. (amp 2006)
    1159. Mucinous carcinomas of the colorectum have distinct molecular genetic characteristics. (PubMed id 15703832)9 Song G.A....Kim Y.S. (Int. J. Oncol. 2005)
    1160. Enzymatic regulation of glucose disposal in human skeletal muscle after a high-fat, low-carbohydrate diet. (PubMed id 15310747)9 Pehleman T.L....Spriet L.L. (J. Appl. Physiol. 2005)
    1161. A homozygous mutation in MSH6 causes Turcot syndrome. (PubMed id 16000562)9 Hegde M.R....Richards C.S. (Clin. Cancer Res. 2005)
    1162. Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer. (PubMed id 16273202)9 Takahashi M....Furukawa Y. (Int. J. Oncol. 2005)
    1163. Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer. (PubMed id 15790394)9 Schnier J.B....Bradbury E.M. (BMC Urol 2005)
    1164. CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype. (PubMed id 15760919)9 Brandes J.C....Herman J.G. (Carcinogenesis 2005)
    1165. [Study on loss of heterozygosity and microsatellite instability in hepatocellular carcinoma]. (PubMed id 15842799)9 Cong W.M....Wu M.C. (Zhonghua Bing Li Xue Za Zhi 2005)
    1166. A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors. (PubMed id 15471898)9 Loeppen S....Schwarz M. (Carcinogenesis 2005)
    1167. CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer. (PubMed id 16336454)9 Kim H.C....Kim J.C. (J. Gastroenterol. Hepatol. 2005)
    1168. Large deletions of the APC gene in 15% of mutation-negative patients with classical polyposis (FAP): a Belgian study. (PubMed id 15643602)9 Michils G....Matthijs G. (Hum. Mutat. 2005)
    1169. [Hereditary colorectal cancer]. (PubMed id 15725711)9 Park J.G. and Kim I.J. (Korean J Gastroenterol 2005)
    1170. The utility of genetically altered mouse models for nutrition and cancer chemoprevention research. (PubMed id 15990122)9 Hursting S.D....Barrett J.C. (Mutat. Res. 2005)
    1171. O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C&gt;A:T transitions. (PubMed id 15888787)9 Halford S....Tomlinson I. (Gut 2005)
    1172. [Carcinogenesis of Barrett's esophagus]. (PubMed id 16101221)9 Endo T....Shinomura Y. (Nippon Rinsho 2005)
    1173. Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance. (PubMed id 15492756)9 Yom S.S....El-Naggar A.K. (Mod. Pathol. 2005)
    1174. Progressive methylation during the serrated neoplasia pathway of the colorectum. (PubMed id 15389252)9 Dong S.M....Kim K.M. (Mod. Pathol. 2005)
    1175. [Endocrine tumors associated to protein Gsalpha/Gi2alpha mutations]. (PubMed id 16444361)9 Bezerra M.G....Fragoso M.C. (Arq Bras Endocrinol Metabol 2005)
    1176. Wingless signaling pathway family relation to colon cancer. Have we come full circle? (PubMed id 15756347)9 Al-Kuraya K.S. and Bhatia K.G. (Saudi Med J 2005)
    1177. Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. (PubMed id 15467712)9 Yang B....Clark D.P. (Mod. Pathol. 2005)
    1178. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. (PubMed id 15942193)9 Brabletz T....Kirchner T. (Cells Tissues Organs (Print) 2005)
    1179. [Hereditary colorectal cancer]. (PubMed id 16266567)9 Bernstein I.T. and BA1low S. (Ugeskr. Laeg. 2005)
    1180. Molecular genetics of adrenocortical tumours, from familial to sporadic diseases. (PubMed id 16189167)9 LibAc R. and Bertherat J. (Eur. J. Endocrinol. 2005)
    1181. Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk. (PubMed id 15824739)9 Schulmann K....Meltzer S.J. (Oncogene 2005)
    1182. Trapping of normal EB1 ligands in aggresomes formed by an EB1 deletion mutant. (PubMed id 15813965)9 Riess N.P....Morrison E.E. (BMC Cell Biol. 2005)
    1183. Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17 cM interval. (PubMed id 15503134)9 Dai Y.C....Chow N.H. (J. Cancer Res. Clin. Oncol. 2005)
    1184. DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. (PubMed id 16166431)9 Zhang J....Clark D.P. (Clin. Cancer Res. 2005)
    1185. Interaction between EB1 and p150glued is required for anaphase astral microtubule elongation and stimulation of cytokinesis. (PubMed id 16360686)9 Strickland L.I....Burgess D.R. (Curr. Biol. 2005)
    1186. Cannabinoid receptor signaling. (PubMed id 16596771)9 Howlett A.C. (Handb Exp Pharmacol 2005)
    1187. Molecular dynamics of a food carcinogen-DNA adduct in a replicative DNA polymerase suggest hindered nucleotide incorporation and extension. (PubMed id 16167826)9 Zhang L....Broyde S. (Chem. Res. Toxicol. 2005)
    1188. Intraductal papillary mucinous neoplasm of the pancreas in a patient with attenuated familial adenomatous polyposis. (PubMed id 15623495)9 Chetty R....Gallinger S. (J. Clin. Pathol. 2005)
    1189. Changes in fat mass influence SREBP-1c and UCP-2 gene expression in formerly obese subjects. (PubMed id 15833942)9 Gniuli D....Mingrone G. (Obes. Res. 2005)
    1190. A second protein kinase CK1-mediated step negatively regulates Wnt signalling by disrupting the lymphocyte enhancer factor-1/beta-catenin complex. (PubMed id 15747065)9 HAommerlein A....Huber O. (Cell. Mol. Life Sci. 2005)
    1191. Who takes the lead in the development of ulcerative colitis-associated colorectal cancers: mutator, suppressor, or methylator pathway? (PubMed id 16157203)9 Maia L....Nobre-LeitALo C. (Cancer Genet. Cytogenet. 2005)
    1192. Molecular genetic alterations and clinical features in early-onset colorectal carcinomas and their role for the recognition of hereditary cancer syndromes. (PubMed id 16181381)9 Losi L....Ponz de Leon M. (Am. J. Gastroenterol. 2005)
    1193. A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes. (PubMed id 15862127)9 Zambrano P....Duenas-GonzA!lez A. (BMC Cancer 2005)
    1194. Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer. (PubMed id 15589597)9 Kang S....Lee H.P. (Gynecol. Oncol. 2005)
    1195. Glucosamine-induced activation of glycogen biosynthesis in isolated adipocytes. Evidence for a rapid allosteric control mechanism within the hexosamine biosynthesis pathway. (PubMed id 15647256)9 Marshall S....Yamasaki K. (J. Biol. Chem. 2005)
    1196. A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA. (PubMed id 15681617)9 Ushijima Y....Nakabeppu Y. (Nucleic Acids Res. 2005)
    1197. Differential functional effects of two 5-HT4 receptor isoforms in adult cardiomyocytes. (PubMed id 15950987)9 Castro L....Fischmeister R. (J. Mol. Cell. Cardiol. 2005)
    1198. Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers. (PubMed id 16207479)9 Ebert M.P....Lofton-Day C. (Neoplasia 2005)
    1199. Methylation assay for the diagnosis of lung cancer on bronchial aspirates: a cohort study. (PubMed id 16278393)9 Schmiemann V....Grote H.J. (Clin. Cancer Res. 2005)
    1200. A genetic approach to cancer epigenetics. (PubMed id 16869770)9 Feinberg A.P. (Cold Spring Harb. Symp. Quant. Biol. 2005)
    1201. Methylation profiling of archived non-small cell lung cancer: a promising prognostic system. (PubMed id 15958624)9 Safar A.M....Fan C.Y. (Clin. Cancer Res. 2005)
    1202. Reconstitution of human telomerase reverse transcriptase expression rescues colorectal carcinoma cells from in vitro senescence: evidence against immortality as a constitutive trait of tumor cells. (PubMed id 15781646)9 Dalerba P....Castelli C. (Cancer Res. 2005)
    1203. MYH mutations in patients with attenuated and classic polyposis and with young-onset colorectal cancer without polyps. (PubMed id 15236166)9 Wang L....Thibodeau S.N. (Gastroenterology 2004)
    1204. Cribriform-morular variant of papillary thyroid carcinoma: clue to early detection of familial adenomatous polyposis-associated colon cancer. (PubMed id 15593462)9 Tomoda C....Kakudo K. (World J Surg 2004)
    1205. Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability. (PubMed id 15021908)9 Guda K....Rosenberg D.W. (Oncogene 2004)
    1206. Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients. (PubMed id 15449173)9 Kim I.J....Park J.G. (Hum. Genet. 2004)
    1207. Genetic and expression profiles of cerebellar liponeurocytomas. (PubMed id 15446583)9 Horstmann S....Ohgaki H. (Brain Pathol. 2004)
    1208. Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers. (PubMed id 15502862)9 Colnot S....Perret C. ( a journal of technical methods and pathology 2004)
    1209. Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer. (PubMed id 15342451)9 Belshaw N.J....Johnson I.T. (amp 2004)
    1210. Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases. (PubMed id 14724163)9 Crabtree M.D....Tomlinson I.P. (Gut 2004)
    1211. Geno- and pheno-typic characterization in ten patients with double-primary gastric and colorectal adenocarcinomas. (PubMed id 15083323)9 Kim J.C....Kang G.H. (Int J Colorectal Dis 2004)
    1212. Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation. (PubMed id 14695993)9 Domingo E....Schwartz S. (amp 2004)
    1213. Mechanism of action of galantamine on N-methyl-D-aspartate receptors in rat cortical neurons. (PubMed id 15121761)9 Moriguchi S....Narahashi T. (J. Pharmacol. Exp. Ther. 2004)
    1214. (S)-Albuterol activates pro-constrictory and pro-inflammatory pathways in human bronchial smooth muscle cells. (PubMed id 15007354)9 Agrawal D.K....Kelbe P.W. (J. Allergy Clin. Immunol. 2004)
    1215. [Promoter methylation profile in breast cancer]. (PubMed id 15543763)9 Roa J.C....Roa I. (Rev Med Chil 2004)
    1216. Pathological features and genetic alterations in colorectal carcinomas with characteristics of nonpolypoid growth. (PubMed id 15213719)9 Kaneko K....Imawari M. (Br. J. Cancer 2004)
    1217. Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia. (PubMed id 15122305)9 Lee S....Kang G.H. ( a journal of technical methods and pathology 2004)
    1218. Tissue preparation for gene expression profiling of colorectal carcinoma: three alternatives to laser microdissection with preamplification. (PubMed id 15192650)9 Croner R.S....Reingruber B. (J. Lab. Clin. Med. 2004)
    1219. Molecular abnormalities in pediatric embryonal brain tumors--analysis of loss of heterozygosity on chromosomes 1, 5, 9, 10, 11, 16, 17 and 22. (PubMed id 15581023)9 Zakrzewska M....Liberski P.P. (Clin. Neuropathol. 2004)
    1220. Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas. (PubMed id 15064707)9 Lee J.H....Wu T.T. (Oncogene 2004)
    1221. Identification of a minimal deletion region on chromosome 5q in Chinese esophageal squamous cell carcinomas. (PubMed id 15488641)9 Li X.D....Wang M.R. (Cancer Lett. 2004)
    1222. CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer. (PubMed id 15154012)9 GutiAcrrez M.I....Bhatia K. (Mod. Pathol. 2004)
    1223. Genetic alterations in locally advanced stage II/III colon cancer: a search for prognostic markers. (PubMed id 15555207)9 Westra J.L....Hofstra R.M. (Clin Colorectal Cancer 2004)
    1224. Different genetic features associated with colon and rectal carcinogenesis. (PubMed id 15217933)9 Frattini M....Pierotti M.A. (Clin. Cancer Res. 2004)
    1225. Molecular analysis of the APC and MYH genes in Czech families affected by FAP or multiple adenomas: 13 novel mutations. (PubMed id 15024739)9 VandrovcovA! J....KohoutovA! M. (Hum. Mutat. 2004)
    1226. Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia. (PubMed id 14702190)9 Tamura G. (Histol. Histopathol. 2004)
    1227. Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116. (PubMed id 15225415)9 Fang J.Y....Lu L.G. (Cell Res. 2004)
    1228. HNPCC and sporadic MSI-H colorectal cancer: a review of the morphological similarities and differences. (PubMed id 15340259)9 Jass J.R. (Fam. Cancer 2004)
    1229. RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1. (PubMed id 15300854)9 Sharp A.... Eccles D. (Hum. Mutat. 2004)
    1230. Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. (PubMed id 15077159)9 Taylor M.D....Rutka J.T. (Oncogene 2004)
    1231. Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. (PubMed id 14747278)9 Holten M.K....Dela F. (Diabetes 2004)
    1232. [Report of the National Oncology Research and Developement Consortium, 2003]. (PubMed id 15105900)9 TA-mA!r J. (Magy Onkol 2004)
    1233. Cribriform-morular variant of papillary thyroid carcinoma: ultrastructural study and somatic/germline mutation analysis of the APC gene. (PubMed id 15205109)9 Kameyama K....Ito K. (Ultrastruct Pathol 2004)
    1234. Brachydactyly type E in two sibs with increased bone density and mental retardation. A new autosomal recessive syndrome? (PubMed id 15658617)9 Stoll C. and Alembik Y. (Genet. Couns. 2004)
    1235. Mutations in components of the Wnt signaling pathway in adenoid cystic carcinoma. (PubMed id 15195113)9 Daa T....Yokoyama S. (Mod. Pathol. 2004)
    1236. Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas. (PubMed id 15067328)9 Ishizaki Y....Asahara T. (Int. J. Oncol. 2004)
    1237. [Genetic aspects of colorectal carcinogenesis]. (PubMed id 15181754)9 Gonciarz M....Petelenz M. (Wiad. Lek. 2004)
    1238. Analysis of missense variation in human BRCA1 in the context of interspecific sequence variation. (PubMed id 15235020)9 Abkevich V....Tavtigian S.V. (J. Med. Genet. 2004)
    1239. Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. (PubMed id 15367334)9 Yu J....Zhu J. (BMC Cancer 2004)
    1240. Correspondence re: T. Zhang et al., Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res., 61: 8664-8667, 2001. (PubMed id 14744799)9 Daidone M.G....Pierotti M.A. (Cancer Res. 2004)
    1241. Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings. (PubMed id 15157044)9 BlAoker H....Penzel R. (Pathol. Res. Pract. 2004)
    1242. Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells. (PubMed id 14555707)9 Rice P.L....Ahnen D.J. (Mol. Cancer Ther. 2003)
    1243. Analysis of the human APC mutation spectrum in a saccharomyces cerevisiae strain with a mismatch repair defect. (PubMed id 12494469)9 Otsuka K....Ishioka C. (Int. J. Cancer 2003)
    1244. Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia. (PubMed id 12888905)9 Uehara E....Koeffler H.P. (Int. J. Oncol. 2003)
    1245. Familial hepatoblastoma and APC gene mutations: renewed call for molecular research. (PubMed id 14522379)9 Thomas Ville de Goyet J. (Eur. J. Cancer 2003)
    1246. Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms. (PubMed id 14501508)9 House M.G....Yeo C.J. (Ann. Surg. 2003)
    1247. Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer. (PubMed id 14514923)9 Bataille F....Hartmann A. (MP, Mol. Pathol. 2003)
    1248. Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas. (PubMed id 12912958)9 De Leng W.W....Keller J.J. (Clin. Cancer Res. 2003)
    1249. Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis. (PubMed id 12746473)9 Kang G.H....Jung H.Y. ( a journal of technical methods and pathology 2003)
    1250. Microsatellite analysis of early stage (Ia-IIb) uterine cervical squamous carcinoma. (PubMed id 14615820)9 Clarke B....Chetty R. (Int. J. Surg. Pathol. 2003)
    1251. MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells. (PubMed id 12907143)9 Mhashilkar A.M....Chada S. (Mol. Ther. 2003)
    1252. The pseudohypoparathyroidism type lb locus is linked to a region including GNAS1 at 20q13.3. (PubMed id 12619926)9 Jan De Beur S.M....Levine M.A. (J. Bone Miner. Res. 2003)
    1253. Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. (PubMed id 12950267)9 MacAulay K....Hundal H.S. (Eur. J. Biochem. 2003)
    1254. Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples. (PubMed id 12821947)9 Waki T....Motoyama T. (Oncogene 2003)
    1255. Relevance of DNA methylation in the management of cancer. (PubMed id 12788407)9 Esteller M. (Lancet Oncol. 2003)
    1256. Evaluation of dHPLC in mutation screening of the APC gene in a Greek FAP cohort. (PubMed id 12894559)9 Mihalatos M....Nasioulas G. (Anticancer Res. 2003)
    1257. &quot;Search-and-capture&quot; of microtubules through plus-end-binding proteins (+TIPs). (PubMed id 14561716)9 Mimori-Kiyosue Y. and Tsukita S. (J. Biochem. 2003)
    1258. Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer. (PubMed id 14527906)9 House M.G....Maitra A. (Ann. Surg. Oncol. 2003)
    1259. Inactivation of cyclin D2 gene in prostate cancers by aberrant promoter methylation. (PubMed id 14581343)9 Padar A....Gazdar A.F. (Clin. Cancer Res. 2003)
    1260. Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. (PubMed id 12853198)9 Sampson J.R.... Cheadle J.P. (Lancet 2003)
    1261. Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis. (PubMed id 12721244)9 Bertario L....Radice P. (J. Clin. Oncol. 2003)
    1262. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. (PubMed id 12669311)9 Blum C.A....Dashwood R.H. (Mol. Carcinog. 2003)
    1263. Role of Smad4 (DPC4) inactivation in human cancer. (PubMed id 12821112)9 Miyaki M. and Kuroki T. (Biochem. Biophys. Res. Commun. 2003)
    1264. Distinct methylation profiles of glioma subtypes. (PubMed id 12794756)9 Uhlmann K....Laird P.W. (Int. J. Cancer 2003)
    1265. The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerization. (PubMed id 12686597)9 Ligon L.A....Holzbaur E.L. (Mol. Biol. Cell 2003)
    1266. A high-throughput nonisotopic protein truncation test. (PubMed id 12524552)9 Gite S....Rothschild K. (Nat. Biotechnol. 2003)
    1267. The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells. (PubMed id 12972572)9 Lecuona E....Sznajder J.I. (Mol. Biol. Cell 2003)
    1268. Molecular genetics and management strategies in hereditary cancer syndromes. (PubMed id 12674901)9 Hanna N.N. and Mentzer R.M. (J Ky Med Assoc 2003)
    1269. Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. (PubMed id 14518068)9 Cohen M.M. (Am. J. Med. Genet. A 2003)
    1270. Expression of junctional proteins in human platelets. (PubMed id 12850834)9 Elrod J.W....Alexander J.S. (Platelets 2003)
    1271. Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. (PubMed id 12213730)9 Lee S....Kang G.H. (Am. J. Pathol. 2002)
    1272. Genetic alterations in adenoma-carcinoma sequencing of intraductal papillary-mucinous neoplasm of the pancreas. (PubMed id 12370756)9 Nakata B....Hirakawa K. (Int. J. Oncol. 2002)
    1273. Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia. (PubMed id 11979558)9 Olipitz W....Sill H. (amp 2002)
    1274. Attenuated familial adenomatous polyposis: an evolving and poorly understood entity. (PubMed id 11786778)9 Hernegger G.S....Guillem J.G. (Dis. Colon Rectum 2002)
    1275. Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. (PubMed id 12213737)9 Rosner A....Cardiff R.D. (Am. J. Pathol. 2002)
    1276. [Genomic alterations in preneoplastic lesions]. (PubMed id 12506466)9 Gemma A. (amp 2002)
    1277. P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells. (PubMed id 12439747)9 Cagatay T. and Ozturk M. (Oncogene 2002)
    1278. Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. (PubMed id 12154064)9 Paz M.F....Esteller M. (Cancer Res. 2002)
    1279. Inherited variants