Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



APBB3 Gene

protein-coding   GIFtS: 55
GCID: GC05M139937

Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member...

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 31 2     Amyloid Beta A4 Precursor Protein-Binding Family B Member 32
FE65L22 3 5     Amyloid Precursor Interacting Protein2
Protein Fe65-Like 22 3     FE65-Like Protein 22
SRA2     Fe65L23

External Ids:    HGNC: 207081   Entrez Gene: 103072   Ensembl: ENSG000001131087   OMIM: 6027115   UniProtKB: O957043   

Export aliases for APBB3 gene to outside databases

Previous GC identifers: GC05M140520 GC05M139913 GC05M139959 GC05M139960 GC05M139910 GC05M139918 GC05M135084


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for APBB3 Gene:
The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to
the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other
APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP.
Multiple transcript variants encoding several different isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for APBB3 Gene:
APBB3 (amyloid beta (A4) precursor protein-binding, family B, member 3) is a protein-coding gene. Diseases associated with APBB3 include alzheimer's disease, and obesity. An important paralog of this gene is APBB2.

UniProtKB/Swiss-Prot: APBB3_HUMAN, O95704
Function: May modulate the internalization of beta-amyloid precursor protein

Gene Wiki entry for APBB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the APBB3 gene promoter:
         CREB   TBP   p53   NRSF form 1   deltaCREB   TFIID   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPBB3 promoter sequence
   Search Chromatin IP Primers for APBB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APBB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31

APBB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APBB3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M139937:  view genomic region     (about GC identifiers)

Start:
139,937,853 bp from pter      End:
139,973,337 bp from pter
Size:
35,485 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: APBB3_HUMAN, O95704 (See protein sequence)
Recommended Name: Amyloid beta A4 precursor protein-binding family B member 3  
Size: 486 amino acids; 52585 Da
Subunit: Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins
2 PDB 3D structures from and Proteopedia for APBB3:
2DYQ (3D)        2YSC (3D)    
Secondary accessions: B3KQN9 Q08AG4 Q96Q18 Q9BYD4 Q9NYX6 Q9NYX7 Q9NYX8
Alternative splicing: 6 isoforms:  O95704-1   O95704-2   O95704-3   O95704-4   O95704-5   O95704-6   (Increased expression upon apoptotic stimuli)

Explore the universe of human proteins at neXtProt for APBB3: NX_O95704

Explore proteomics data for APBB3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See APBB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_006042.3  NP_573418.2  NP_573419.2  NP_573420.2  

    ENSEMBL proteins: 
     ENSP00000426107   ENSP00000422718   ENSP00000349177   ENSP00000346378   ENSP00000350171  
     ENSP00000427272   ENSP00000402591   ENSP00000424317   ENSP00000444013   ENSP00000351389  

    APBB3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for APBB3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for APBB3
    GenScript Custom Purified and Recombinant Proteins Services for APBB3
    Novus Biologicals APBB3 Protein
    Novus Biologicals APBB3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for APBB3

    APBB3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for APBB3
    OriGene Custom Antibody Services for APBB3
    Novus Biologicals APBB3 Antibodies
    Abcam antibodies for APBB3
    Cloud-Clone Corp. Antibodies for APBB3
    ThermoFisher Antibodies for APBB3
    LSBio Antibodies in human, mouse, rat for APBB3

    APBB3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for APBB3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for APBB3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for APBB3
    Cloud-Clone Corp. CLIAs for APBB3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR006020 PTB/PI_dom
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry O95704

    ProtoNet protein and cluster: O95704

    1 Blocks protein domain: IPB006020 Phosphotyrosine interaction domain

    UniProtKB/Swiss-Prot: APBB3_HUMAN, O95704
    Similarity: Contains 2 PID domains
    Similarity: Contains 1 WW domain


    APBB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APBB3_HUMAN, O95704
    Function: May modulate the internalization of beta-amyloid precursor protein

         Genatlas biochemistry entry for APBB3:
    amyloid beta (A4) precursor protein binding B3,murine homolog,FE65 like gene,interacting with Alzheimer's beta
    amyloid precursor protein

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10081969
         
    APBB3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for APBB3:
     Decreased TP53 protein express  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APBB3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APBB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APBB3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APBB3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat APBB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APBB3 (see all 15):
    hsa-miR-1290 hsa-miR-142-5p hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-340 hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidAPBB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for APBB3
    Predesigned siRNA for gene silencing in human, mouse, rat APBB3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for APBB3

    Clone
    Products:
         
    OriGene clones in human, mouse for APBB3 (see all 21)
    OriGene ORF clones in mouse, rat for APBB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): APBB3 (NM_006051)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APBB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APBB3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for APBB3
    Browse ESI BIO Cell Lines and PureStem Progenitors for APBB3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APBB3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    APBB3_HUMAN, O95704: Cytoplasm. Nucleus
    APBB3_HUMAN, O95704: Isoform I-214: Nucleus
    APBB3_HUMAN, O95704: Isoform I-245: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0015629actin cytoskeleton IDA--

    APBB3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APBB3
    Interactions:

        GeneGlobe Interaction Network for APBB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for APBB3 (O957041, 2, 3 ENSP000003463784) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3MINT-74477 I2D: score=2 
    EGFRP005331, 2, 3, ENSP000002754934EBI-286427,EBI-297353 MINT-74475 MINT-74476 I2D: score=2 STRING: ENSP00000275493
    APPP050673, ENSP000002849814I2D: score=7 STRING: ENSP00000284981
    APLP1P516933, ENSP000002218914I2D: score=1 STRING: ENSP00000221891
    APLP2Q064813, ENSP000002635744I2D: score=5 STRING: ENSP00000263574
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APBB3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for APBB3 gene (6 alternative transcripts): 
    NM_006051.3  NM_133172.2  NM_133173.2  NM_133174.2  NM_133175.1  NM_133176.1  

    Unigene Cluster for APBB3:

    Amyloid beta (A4) precursor protein-binding, family B, member 3
    Hs.529449  [show with all ESTs]
    Unigene Representative Sequence: AK125244
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000515056(uc003lgb.1) ENST00000509914 ENST00000510241(uc003lgc.1 uc003lgd.1 uc010jfp.1 uc011czi.1 uc021yeg.1 uc003lgf.1)
    ENST00000467078 ENST00000356738 ENST00000354402 ENST00000357560(uc003lge.1 uc021yeh.1)
    ENST00000511896 ENST00000412920 ENST00000511201 ENST00000504872 ENST00000506289
    ENST00000511463 ENST00000503979 ENST00000513507 ENST00000505617 ENST00000506958
    ENST00000507279

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat APBB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APBB3 (see all 15):
    hsa-miR-1290 hsa-miR-142-5p hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-340 hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidAPBB3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for APBB3
    Predesigned siRNA for gene silencing in human, mouse, rat APBB3
    Clone
    Products:
         
    OriGene clones in human, mouse for APBB3 (see all 21)
    OriGene ORF clones in mouse, rat for APBB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): APBB3 (NM_006051)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APBB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APBB3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for APBB3
    OriGene qSTAR qPCR primer pairs in human, mouse for APBB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APBB3
      QuantiTect SYBR Green Assays in human, mouse, rat APBB3
      QuantiFast Probe-based Assays in human, mouse, rat APBB3

    Additional mRNA sequence: 

    AB018247.1 AB079687.1 AB094990.1 AB209839.1 AF224708.1 AF224709.1 AF224710.1 AF224711.1 
    AK074885.1 AK075280.1 AK125244.1 AK304824.1 AK307170.1 BC013158.1 BC125187.1 

    23 DOTS entries:

    DT.120809089  DT.95166855  DT.95204941  DT.92437826  DT.97769432  DT.92458990  DT.97855095  DT.100815438 
    DT.86840740  DT.100815437  DT.100810894  DT.40316838  DT.100815427  DT.120809268  DT.99971860  DT.120809171 
    DT.120809267  DT.120809095  DT.120809104  DT.92458996  DT.95167015  DT.92027807  DT.97798844 

    Selected AceView cDNA sequences (see all 420):

    BM980607 NM_133174 BG315276 CA433678 BE513494 AU279932 AA384327 BM460451 
    AA833851 BM717898 CB853471 BE793975 W49526 NM_133176 CR595828 AA804604 
    CB139835 AB049618 AA381828 CA431393 BQ052761 BU625023 AI524742 BQ006470 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for APBB3 (see all 20)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
    SP1:                                                              -     -                                   -                       -     -                     
    SP2:                                                              -     -                                         -                 -     -                     
    SP3:                                                              -     -                                         -     -     -     -                           
    SP4:                                                              -     -                                         -     -     -     -     -                     
    SP5:                                                              -     -                                                                                       

    ExUns: 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c
    SP1:                    -           -                       -                                                                           
    SP2:                    -           -                       -                                                                           
    SP3:                    -           -                       -                                                                           
    SP4:                    -           -                       -                                                                           
    SP5:                    -           -                       -                                                                           


    ECgene alternative splicing isoforms for APBB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    APBB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAACTCTG
    APBB3 Expression
    About this image

    APBB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APBB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529449

    UniProtKB/Swiss-Prot: APBB3_HUMAN, O95704
    Tissue specificity: Expressed in various tissues, highest expression in brain

        Custom PCR Arrays for APBB3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for APBB3
    OriGene qSTAR qPCR primer pairs in human, mouse for APBB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APBB3
    QuantiTect SYBR Green Assays in human, mouse, rat APBB3
    QuantiFast Probe-based Assays in human, mouse, rat APBB3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APBB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for APBB3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apbb31 , 5 amyloid beta (A4) precursor protein-binding, family more1, 5 88.04(n)1
    91.75(a)1
      18 (19.46 cM)5
    2253721  NM_146085.11  NP_666197.11 
     366711605 
    chicken
    (Gallus gallus)
    Aves APBB31 amyloid beta (A4) precursor protein-binding, family more 63.73(n)
    57.85(a)
      101750838  XM_004944747.1  XP_004944804.1 
    lizard
    (Anolis carolinensis)
    Reptilia APBB36
    amyloid beta (A4) precursor protein-binding, famil...
    56(a)
    1 ↔ 1
    4(77903757-77913860)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia apbb31 amyloid beta (A4) precursor protein-binding, family more 60.56(n)
    56.04(a)
      100125004  NM_001102932.1  NP_001096402.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018831581 amyloid beta A4 precursor protein-binding family B more 62.02(n)
    53.28(a)
      101883158  XM_005161445.1  XP_005161502.1 
    worm
    (Caenorhabditis elegans)
    Secernentea feh-16
    Protein FEH-1, isoform a (feh-1) mRNA, complete cd...
    17(a)
    1 → many
    III(2549927-2560686) WBGene00001410


    ENSEMBL Gene Tree for APBB3 (if available)
    TreeFam Gene Tree for APBB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for APBB3 gene
    APBB22  APBB12  
    4 SIMAP similar genes for APBB3 using alignment to 8 protein entries:     APBB3_HUMAN (see all proteins):
    Fe65L2 isoform 484    APBB2    APBB1    DKFZp686G05200

    APBB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for APBB3 (see all 134)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs787059381,2
    C,F--139939874(+) CCACCA/CACCCA 4 -- int13Minor allele frequency- C:0.02CSA WA EU 1444
    rs1824827201,2
    C--139939887(+) CCCACC/TCATGA 4 -- int10--------
    rs2012389321,2
    --139939921(+) AGCTTC/TAGAGA 8 K E mis10--------
    rs1480099891,2
    C,F--139939929(+) AGAGTC/TCCCCT 8 E G mis12Minor allele frequency- T:0.00NA EU 5869
    rs617369401,2
    C,F--139939961(+) GCTGCG/ACACTG 8 /C syn14Minor allele frequency- A:0.02NS NA EU 6067
    rs2007970981,2
    --139940030(+) CCAATA/GAATGT 8 F syn10--------
    rs1156112311,2
    C,F--139940044(+) AAGGCG/ACACAG 8 /R /C mis12Minor allele frequency- A:0.00NA 4644
    rs1995454271,2
    --139940061(+) GCCACA/GATGGC 8 S L mis10--------
    rs1424982791,2
    C--139940128(+) AGCACA/GGGCCA 4 -- int10--------
    rs2018500621,2
    C--139940129(+) GCACGA/GGCCAG 4 -- int10--------

    HapMap Linkage Disequilibrium report for APBB3 (139937853 - 139973337 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for APBB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462462CNV Loss19166990

    Human Gene Mutation Database (HGMD): APBB3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APBB3
    DNA2.0 Custom Variant and Variant Library Synthesis for APBB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602711    OMIM disorders: --

    2 diseases for APBB3:    
    About MalaCards
    alzheimer's disease    obesity


    APBB3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): APBB3

    Export disorders for APBB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for APBB3 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with APBB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains. (PubMed id 12153398)1, 2, 9 Tanahashi H. and Tabira T. (Biochem. J. 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein. (PubMed id 10081969)1, 2 Tanahashi H. (Neurosci. Lett. 1999)
    5. Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein. (PubMed id 10329396)1, 2 Tanahashi H. and Tabira T. (Biochem. Biophys. Res. Commun. 1999)
    6. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. (PubMed id 9407065)1, 3 Ermekova K.S....Sudol M. (J. Biol. Chem. 1997)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. (PubMed id 20205790)1 Kajiwara Y....Buxbaum J.D. (Mol Neurodegener 2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. A quantitative protein interaction network for the ErbB receptors using protein microarrays. (PubMed id 16273093)1 Jones R.B....MacBeath G. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10307 HGNC: 20708 AceView: APBB3andSRA1 Ensembl:ENSG00000113108 euGenes: HUgn10307
    ECgene: APBB3 H-InvDB: APBB3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for APBB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for APBB3 gene:
    Search GeneIP for patents involving APBB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for APBB3   OriGene RNAi products in human, mouse, rat for APBB3  
     OriGene qPCR primer pairs and template standards for APBB3   OriGene Protein Over-expression Lysate for APBB3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for APBB3  
     OriGene qSTAR qPCR primer pairs in human, mouse for APBB3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for APBB3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for APBB3   OriGene Custom Protein Services for APBB3  

     
     
     Block miRNA regulation of human, mouse, rat APBB3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing APBB3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APBB3 Predesigned siRNA for gene silencing in human, mouse, rat APBB3
     QuantiFast Probe-based Assays in human, mouse, rat APBB3 QuantiTect SYBR Green Assays in human, mouse, rat APBB3
     Custom PCR Arrays for APBB3 Search Chromatin IP Primers for APBB3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APBB3  GeneGlobe Interaction Network for APBB3
     Regulatory tfbs in APBB3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for APBB3 GenScript cDNA clones with any tag delivered in your preferred vector for APBB3
     GenScript Custom Assay Services for APBB3 GenScript Custom overexpressing Cell Line Services for APBB3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for APBB3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     APBB3 antibodies
     APBB3 proteins
     APBB3 lysates
     Antibodies for APBB3
     See all of Abcam's Antibodies, Kits and Proteins for APBB3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for APBB3
     Antibodies for APBB3
     ELISAs for APBB3
     CLIAs for APBB3



     Browse ESI BIO Cell Lines and PureStem Progenitors for APBB3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APBB3
     SwitchGear 3'UTR luciferase reporter plasmids for APBB3
     SwitchGear Promoter luciferase reporter plasmids for APBB3
     ThermoFisher Antibodies for APBB3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APBB3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APBB3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APBB3
     LSBio Antibodies in human, mouse, rat for APBB3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      APBB3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4