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Aliases for APBB3 Gene

Aliases for APBB3 Gene

  • Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 3 2 3
  • FE65L2 3 4 6
  • Protein Fe65-Like 2 3 4
  • Amyloid Beta A4 Precursor Protein-Binding Family B Member 3 3
  • Amyloid Precursor Interacting Protein 3
  • FE65-Like Protein 2 3
  • SRA 3

External Ids for APBB3 Gene

Summaries for APBB3 Gene

Entrez Gene Summary for APBB3 Gene

  • The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for APBB3 Gene

APBB3 (Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 3) is a Protein Coding gene. An important paralog of this gene is APBB2.

UniProtKB/Swiss-Prot for APBB3 Gene

  • May modulate the internalization of beta-amyloid precursor protein

Gene Wiki entry for APBB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APBB3 Gene

Genomics for APBB3 Gene

Genomic Location for APBB3 Gene

Start:
140,558,268 bp from pter
End:
140,593,752 bp from pter
Size:
35,485 bases
Orientation:
Minus strand

Genomic View for APBB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APBB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APBB3 Gene

Regulatory Elements for APBB3 Gene

Proteins for APBB3 Gene

  • Protein details for APBB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95704-APBB3_HUMAN
    Recommended name:
    Amyloid beta A4 precursor protein-binding family B member 3
    Protein Accession:
    O95704
    Secondary Accessions:
    • B3KQN9
    • Q08AG4
    • Q96Q18
    • Q9BYD4
    • Q9NYX6
    • Q9NYX7
    • Q9NYX8

    Protein attributes for APBB3 Gene

    Size:
    486 amino acids
    Molecular mass:
    52585 Da
    Quaternary structure:
    • Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins

    Three dimensional structures from OCA and Proteopedia for APBB3 Gene

    Alternative splice isoforms for APBB3 Gene

neXtProt entry for APBB3 Gene

Proteomics data for APBB3 Gene at MOPED

Post-translational modifications for APBB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for APBB3 Gene

Domains for APBB3 Gene

Protein Domains for APBB3 Gene

Graphical View of Domain Structure for InterPro Entry

O95704

UniProtKB/Swiss-Prot:

APBB3_HUMAN
Domain:
  • Contains 2 PID domains.:
    • O95704
  • Contains 1 WW domain.:
    • O95704
genes like me logo Genes that share domains with APBB3: view

No data available for Gene Families for APBB3 Gene

Function for APBB3 Gene

Molecular function for APBB3 Gene

GENATLAS Biochemistry: amyloid beta (A4) precursor protein binding B3,murine homolog,FE65 like gene,interacting with Alzheimers beta amyloid precursor protein
UniProtKB/Swiss-Prot Function: May modulate the internalization of beta-amyloid precursor protein

Gene Ontology (GO) - Molecular Function for APBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IBA --
GO:0005515 protein binding IPI 10081969
GO:0008134 transcription factor binding IBA --
genes like me logo Genes that share ontologies with APBB3: view
genes like me logo Genes that share phenotypes with APBB3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APBB3 Gene

Localization for APBB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APBB3 Gene

Cytoplasm. Nucleus.
Isoform I-214: Nucleus.
Isoform I-245: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APBB3 Gene COMPARTMENTS Subcellular localization image for APBB3 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for APBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with APBB3: view

Pathways for APBB3 Gene

SuperPathways for APBB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for APBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with APBB3: view

No data available for Pathways by source for APBB3 Gene

Transcripts for APBB3 Gene

Unigene Clusters for APBB3 Gene

Amyloid beta (A4) precursor protein-binding, family B, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APBB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - - - -
SP7:
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - -
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13: -
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: -

Relevant External Links for APBB3 Gene

GeneLoc Exon Structure for
APBB3
ECgene alternative splicing isoforms for
APBB3

Expression for APBB3 Gene

mRNA expression in normal human tissues for APBB3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APBB3 Gene

SOURCE GeneReport for Unigene cluster for APBB3 Gene Hs.529449

mRNA Expression by UniProt/SwissProt for APBB3 Gene

O95704-APBB3_HUMAN
Tissue specificity: Expressed in various tissues, highest expression in brain.
genes like me logo Genes that share expressions with APBB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for APBB3 Gene

Orthologs for APBB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for APBB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APBB3 35
  • 99.46 (n)
  • 98.78 (a)
APBB3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APBB3 35
  • 92.46 (n)
  • 94.24 (a)
APBB3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APBB3 35
  • 92.22 (n)
  • 94.52 (a)
APBB3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apbb3 35
  • 88.04 (n)
  • 91.75 (a)
Apbb3 16
Apbb3 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APBB3 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APBB3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apbb3 35
  • 87.59 (n)
  • 91.42 (a)
chicken
(Gallus gallus)
Aves APBB3 35
  • 63.73 (n)
  • 57.85 (a)
APBB3 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APBB3 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apbb3 35
  • 60.56 (n)
  • 56.04 (a)
zebrafish
(Danio rerio)
Actinopterygii APBB3 36
  • 51 (a)
OneToOne
LOC101883158 35
  • 62.02 (n)
  • 53.28 (a)
worm
(Caenorhabditis elegans)
Secernentea feh-1 36
  • 17 (a)
OneToMany
Species with no ortholog for APBB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APBB3 Gene

ENSEMBL:
Gene Tree for APBB3 (if available)
TreeFam:
Gene Tree for APBB3 (if available)

Paralogs for APBB3 Gene

Paralogs for APBB3 Gene

genes like me logo Genes that share paralogs with APBB3: view

Variants for APBB3 Gene

Sequence variations from dbSNP and Humsavar for APBB3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs171632 -- 140,561,733(-) CCAGC(C/T)TCTAC intron-variant
rs250430 - 140,561,643(-) TGTTT(C/T)GCTGT missense, reference
rs250431 -- 140,560,648(-) GCACA(C/T)CCCAT reference, synonymous-codon
rs1008238 -- 140,560,954(-) GGTGA(C/G)GCCTG intron-variant
rs1800882 -- 140,560,717(-) CTCAC(C/T)GCCAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for APBB3 Gene

Variant ID Type Subtype PubMed ID
nsv462462 CNV Loss 19166990

Relevant External Links for APBB3 Gene

HapMap Linkage Disequilibrium report
APBB3
Human Gene Mutation Database (HGMD)
APBB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APBB3 Gene

Disorders for APBB3 Gene

Relevant External Links for APBB3

Genetic Association Database (GAD)
APBB3
genes like me logo Genes that share disorders with APBB3: view

No data available for UniProtKB/Swiss-Prot for APBB3 Gene

Publications for APBB3 Gene

  1. Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains. (PMID: 12153398) Tanahashi H. … Tabira T. (Biochem. J. 2002) 3 4 23
  2. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. (PMID: 9407065) Ermekova K.S. … Sudol M. (J. Biol. Chem. 1997) 2 3
  3. Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein. (PMID: 10081969) Tanahashi H. (Neurosci. Lett. 1999) 3 4
  4. Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein. (PMID: 10329396) Tanahashi H. … Tabira T. (Biochem. Biophys. Res. Commun. 1999) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for APBB3 Gene

Sources for APBB3 Gene

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