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Aliases for APBB3 Gene

Aliases for APBB3 Gene

  • Amyloid Beta Precursor Protein Binding Family B Member 3 2 3
  • Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 3 2 3 5
  • Protein Fe65-Like 2 3 4
  • FE65L2 3 4
  • Amyloid Precursor Interacting Protein 3
  • FE65-Like Protein 2 3
  • SRA 3

External Ids for APBB3 Gene

Previous GeneCards Identifiers for APBB3 Gene

  • GC05M140520
  • GC05M139913
  • GC05M139959
  • GC05M139960
  • GC05M139910
  • GC05M139918
  • GC05M135084
  • GC05M139937

Summaries for APBB3 Gene

Entrez Gene Summary for APBB3 Gene

  • The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for APBB3 Gene

APBB3 (Amyloid Beta Precursor Protein Binding Family B Member 3) is a Protein Coding gene. Diseases associated with APBB3 include Alzheimer Disease. GO annotations related to this gene include transcription factor binding and beta-amyloid binding. An important paralog of this gene is APBB1.

UniProtKB/Swiss-Prot for APBB3 Gene

  • May modulate the internalization of beta-amyloid precursor protein.

Gene Wiki entry for APBB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APBB3 Gene

Genomics for APBB3 Gene

Regulatory Elements for APBB3 Gene

Enhancers for APBB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APBB3 on UCSC Golden Path with GeneCards custom track

Promoters for APBB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APBB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for APBB3 Gene

140,558,268 bp from pter
140,593,752 bp from pter
35,485 bases
Minus strand

Genomic View for APBB3 Gene

Genes around APBB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APBB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APBB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APBB3 Gene

Proteins for APBB3 Gene

  • Protein details for APBB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amyloid beta A4 precursor protein-binding family B member 3
    Protein Accession:
    Secondary Accessions:
    • B3KQN9
    • Q08AG4
    • Q96Q18
    • Q9BYD4
    • Q9NYX6
    • Q9NYX7
    • Q9NYX8

    Protein attributes for APBB3 Gene

    486 amino acids
    Molecular mass:
    52585 Da
    Quaternary structure:
    • Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins.

    Three dimensional structures from OCA and Proteopedia for APBB3 Gene

    Alternative splice isoforms for APBB3 Gene

neXtProt entry for APBB3 Gene

Proteomics data for APBB3 Gene at MOPED

Post-translational modifications for APBB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for APBB3 Gene

Domains & Families for APBB3 Gene

Protein Domains for APBB3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 PID domains.
  • Contains 2 PID domains.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with APBB3: view

No data available for Gene Families for APBB3 Gene

Function for APBB3 Gene

Molecular function for APBB3 Gene

GENATLAS Biochemistry:
amyloid beta (A4) precursor protein binding B3,murine homolog,FE65 like gene,interacting with Alzheimers beta amyloid precursor protein
UniProtKB/Swiss-Prot Function:
May modulate the internalization of beta-amyloid precursor protein.

Gene Ontology (GO) - Molecular Function for APBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IBA --
genes like me logo Genes that share ontologies with APBB3: view
genes like me logo Genes that share phenotypes with APBB3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APBB3 Gene

Localization for APBB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APBB3 Gene

Cytoplasm. Nucleus.
Isoform I-214: Nucleus.
Isoform I-245: Nucleus.

Subcellular locations from

Jensen Localization Image for APBB3 Gene COMPARTMENTS Subcellular localization image for APBB3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for APBB3 Gene

Pathways & Interactions for APBB3 Gene

SuperPathways for APBB3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for APBB3 Gene


No data available for Pathways by source and SIGNOR curated interactions for APBB3 Gene

Drugs & Compounds for APBB3 Gene

No Compound Related Data Available

Transcripts for APBB3 Gene

Unigene Clusters for APBB3 Gene

Amyloid beta (A4) precursor protein-binding, family B, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APBB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - -
SP15: -

ExUns: 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP11: -
SP12: -
SP13: -
SP14: - -
SP20: -

Relevant External Links for APBB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APBB3 Gene

mRNA expression in normal human tissues for APBB3 Gene

Protein differential expression in normal tissues from HIPED for APBB3 Gene

This gene is overexpressed in Liver, secretome (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APBB3 Gene

SOURCE GeneReport for Unigene cluster for APBB3 Gene Hs.529449

mRNA Expression by UniProt/SwissProt for APBB3 Gene

Tissue specificity: Expressed in various tissues, highest expression in brain.
genes like me logo Genes that share expression patterns with APBB3: view

Protein tissue co-expression partners for APBB3 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for APBB3 Gene

Orthologs for APBB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for APBB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia APBB3 35
  • 92.46 (n)
  • 94.24 (a)
APBB3 36
  • 94 (a)
(Canis familiaris)
Mammalia APBB3 35
  • 92.22 (n)
  • 94.52 (a)
APBB3 36
  • 92 (a)
(Mus musculus)
Mammalia Apbb3 35
  • 88.04 (n)
  • 91.75 (a)
Apbb3 16
Apbb3 36
  • 91 (a)
(Pan troglodytes)
Mammalia APBB3 35
  • 99.46 (n)
  • 98.78 (a)
APBB3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Apbb3 35
  • 87.59 (n)
  • 91.42 (a)
(Monodelphis domestica)
Mammalia APBB3 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia APBB3 36
  • 81 (a)
(Gallus gallus)
Aves APBB3 35
  • 63.73 (n)
  • 57.85 (a)
APBB3 36
  • 53 (a)
(Anolis carolinensis)
Reptilia APBB3 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia apbb3 35
  • 60.56 (n)
  • 56.04 (a)
(Danio rerio)
Actinopterygii LOC101883158 35
  • 62.02 (n)
  • 53.28 (a)
APBB3 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea feh-1 36
  • 17 (a)
Species with no ortholog for APBB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APBB3 Gene

Gene Tree for APBB3 (if available)
Gene Tree for APBB3 (if available)

Paralogs for APBB3 Gene

Paralogs for APBB3 Gene

genes like me logo Genes that share paralogs with APBB3: view

Variants for APBB3 Gene

Sequence variations from dbSNP and Humsavar for APBB3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs250430 - 140,561,643(-) TGTTT(C/T)GCTGT reference, missense
rs7715021 - 140,562,358(+) CTCAC(C/G)CCAGG reference, missense
rs1008238 -- 140,560,954(-) GGTGA(C/G)GCCTG intron-variant
rs171632 -- 140,561,733(-) CCAGC(C/T)TCTAC intron-variant
rs3180282 -- 140,561,091(-) CTGCT(A/G)GATGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for APBB3 Gene

Variant ID Type Subtype PubMed ID
nsv462462 CNV Loss 19166990

Variation tolerance for APBB3 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APBB3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APBB3 Gene

Disorders for APBB3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for APBB3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search APBB3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for APBB3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with APBB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APBB3 Gene

Publications for APBB3 Gene

  1. Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains. (PMID: 12153398) Tanahashi H. … Tabira T. (Biochem. J. 2002) 3 4 23 67
  2. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. (PMID: 9407065) Ermekova K.S. … Sudol M. (J. Biol. Chem. 1997) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. (PMID: 20205790) Kajiwara Y. … Buxbaum J.D. (Mol Neurodegener 2010) 3

Products for APBB3 Gene

Sources for APBB3 Gene