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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APBB2 Gene

protein-coding GIFtS: 55
GCID: GC04M040812

amyloid beta (A4) precursor protein-binding, family B, member...

Explore 6 diseases affiliated with
APBB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 2¹ ²		MGC35575¹
FE65L1¹ ² ³ ⁵		Amyloid Beta A4 Precursor Protein-Binding Family B Member 2²
FE65L¹ ² ³		Fe65-Like 1²
Protein Fe65-Like 1² ³

External Ids:	HGNC: 582¹	Entrez Gene: 323²	Ensembl: ENSG00000163697⁷	OMIM: 602710⁵	UniProtKB: Q92870³

Export aliases for APBB2 gene to outside databases

Previous GC identifers: GC04M040883 GC04M041100 GC04M040666 GC04M040732 GC04M040657 GC04M040510 GC04M040134

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APBB2:

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and

amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are

thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease.

Alternative splicing results in multiple transcript variants. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: APBB2_HUMAN, Q92870

Function: May modulate the internalization of beta-amyloid precursor protein

Gene Wiki entry for APBB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_006238.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APBB2 gene promoter:
STAT5B STAT1 Pax-5 STAT4 STAT1beta STAT5A STAT1alpha GATA-2 STAT2 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): APBB2 promoter sequence

Search SABiosciences Chromatin IP Primers for APBB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APBB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p13 Ensembl cytogenetic band: 4p13 HGNC cytogenetic band: 4p13

APBB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APBB2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M040812: view genomic region (about GC identifiers)

Start:	40,812,044 bp from pter	End:	41,218,731 bp from pter
Size:	406,688 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APBB2_HUMAN, Q92870 (See protein sequence)

Recommended Name: Amyloid beta A4 precursor protein-binding family B member 2

Size: 758 amino acids; 83374 Da

Subunit: Binds to the intracellular domain of the beta-amyloid precursor protein

Sequence caution: Sequence=AAC50805.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown

origin in the N-terminal part;

Secondary accessions: B4DSL4 E9PG87 Q8IUI6

Alternative splicing: 4 isoforms: Q92870-1 Q92870-2 Q92870-3 Q92870-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APBB2: NX_Q92870

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92870

APBB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001159522.1 NP_001159523.1 NP_001159524.1 NP_001159525.1 NP_001159526.1 NP_004298.1 NP_775098.2

ENSEMBL proteins:

ENSP00000295974 ENSP00000426018 ENSP00000427307 ENSP00000427211 ENSP00000425802

ENSP00000421539 ENSP00000423765 ENSP00000422948 ENSP00000426429 ENSP00000427107

ENSP00000421751 ENSP00000421301 ENSP00000425121 ENSP00000424414 ENSP00000424579

ENSP00000425202 ENSP00000422723 ENSP00000421205 ENSP00000439357

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	Uscn Proteins for APBB2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	--	--
GO:0016020	membrane	NAS	8855266
GO:0030027	lamellipodium	ISS	--

APBB2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

APBB2 for domains About GeneDecksing

3 InterPro domains/families:

IPR006020 PTyr_interaction_dom

IPR001202 WW_Rsp5_WWP

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q92870

ProtoNet protein and cluster: Q92870

1 Blocks protein family: IPB006020 Phosphotyrosine interaction domain

UniProtKB/Swiss-Prot: APBB2_HUMAN, Q92870

Similarity: Contains 2 PID domains

Similarity: Contains 1 WW domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: APBB2_HUMAN, Q92870

Function: May modulate the internalization of beta-amyloid precursor protein

Genatlas biochemistry entry for APBB2:

amyloid beta (A4) precursor binding protein B2,murine homolog of Fe65 like gene

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001540	beta-amyloid binding	ISS	--
GO:0005515	protein binding	IPI	8855266
GO:0008134	transcription factor binding	ISS	--

APBB2 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Apbb2):

cellular

growth/size

mortality/aging

nervous system

normal

APBB2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Apbb2^tm1Her for APBB2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for APBB2

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		hsa-miR-411* hsa-miR-520f hsa-miR-106a hsa-miR-605 hsa-miR-134 hsa-miR-1260b hsa-miR-342-3p hsa-miR-3921

		SwitchGear 3'UTR luciferase reporter plasmid: APBB2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APBB2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for APBB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/9 Interacting proteins for APBB2 (Q92870^{1, 2, 3} ENSP00000295974⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APP	P05067¹^,³, ENSP00000284981⁴	EBI-79277,EBI-77613 I2D: score=5 STRING: ENSP00000284981
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-74472 MINT-74471 MINT-74474 MINT-74473 I2D: score=1 STRING: ENSP00000275493
SMURF1	Q9HCE7³, ENSP00000354621⁴	I2D: score=2 STRING: ENSP00000354621
APLP2	Q06481³, ENSP00000263574⁴	I2D: score=3 STRING: ENSP00000263574
SMAD4	Q13485³, ENSP00000341551⁴	I2D: score=4 STRING: ENSP00000341551

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	--	--
GO:0006355	regulation of transcription, DNA-dependent	ISS	--
GO:0007050	cell cycle arrest	ISS	--
GO:0007411	axon guidance	--	--
GO:0030198	extracellular matrix organization	--	--

APBB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for APBB2
Search CenterWatch for drugs/clinical trials and news about APBB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APBB2 gene (7 alternative transcripts):

NM_001166050.1 NM_001166051.1 NM_001166052.1 NM_001166053.1 NM_001166054.1 NM_004307.1 NM_173075.4

Unigene Cluster for APBB2:

Amyloid beta (A4) precursor protein-binding, family B, member 2

Hs.479602 [show with all ESTs]

Unigene Representative Sequence: NM_004307

18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):

ENST00000295974(uc010ifu.3 uc003gvl.3 uc003gvn.3 uc003gvm.3)

ENST00000513140 ENST00000513611 ENST00000508593 ENST00000502841 ENST00000506352

ENST00000504305 ENST00000502687 ENST00000510925 ENST00000512510 ENST00000510670

ENST00000514920 ENST00000507831 ENST00000513516 ENST00000513493 ENST00000514094

ENST00000509475(uc011byt.1) ENST00000504484

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Additional cDNA sequence:

AK024871.1 AK226179.1 AK289838.1 AK295974.1 AK299800.1 AK304247.1 AL080130.1 BC027946.1

BC088372.1

18 DOTS entries:

DT.455435 DT.306651 DT.100805276 DT.100810565 DT.121255262 DT.97767831 DT.99935411 DT.100028433

DT.100805280 DT.95366170 DT.121255397 DT.91697646 DT.121255407 DT.121255448 DT.75120714 DT.99971214

DT.40281203 DT.95183247

24/236 AceView cDNA sequences (see all 236):

BQ925153 BQ012565 AA374714 BU948373 CR621132 BF438341 AI609693 BM546898

CB960053 BM142507 AA663331 NM_173075 AL080130 BM142332 AI919212 BQ881693

BP872129 BG023881 AA496214 AW874579 CK429594 CR607261 AA496238 CD514931

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for APBB2 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18	^	19	^	20	^
SP1:					-																				-		-												-
SP2:																									-														-
SP3:																									-
SP4:					-								-
SP5:											-

ExUns:	21a	·	21b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for APBB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APBB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTACAGCTG

About this image

APBB2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See APBB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APBB2

SOURCE GeneReport for Unigene cluster: Hs.479602

SABiosciences Expression via Pathway-Focused PCR Array including APBB2:

Alzheimer's Disease in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for APBB2 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	APBB2¹	amyloid beta (A4) precursor protein-binding, family B, member 2 less	82.16(n) 90.44(a)		422781 XM_420735.3 XP_420735.3
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	91(a) 87(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	5(100310178-100343103) 5(100253191-100261067)
zebrafish (Danio rerio)	Actinopterygii	LOC564990¹	amyloid beta A4 precursor protein-binding family B member 2-like less	67.44(n) 71.23(a)		564990 XM_688300.5 XP_693392.5
honey bee (Apis mellifera)	Insecta	--	--	29(a)	1 → many	Group2.8(139556-232982)
worm (Caenorhabditis elegans)	Secernentea	feh-1⁶	mammalian FE65 Homolog family member (feh-1)	24(a)	1 → many	III(2549918-2560677)

ENSEMBL Gene Tree for APBB2 (if available)
TreeFam Gene Tree for APBB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for APBB2 gene

APBB3² APBB1²

5 SIMAP similar genes for APBB2 using alignment to 14 protein entries: APBB2_HUMAN (see all proteins):

DKFZp686G05200 APBB1 APBB3 Fe65L2 Fe65L2 isoform 484

APBB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6850173^1,2	C,F,H	--	40133640(+)	`TTAATA/GATTCT`	7	--	ds500¹		14		NA NS EA WA	1350
rs60093480^1,2		--	40134700(+)	`TCAGCG/TTATTT`	7	--	ut3¹		0	--	--	--	--
rs10007725^1,2	C	--	40134726(+)	`TCAAAA/CACTAT`	7	--	ut3¹		0	--	--	--	--
rs73810657^1,2	C	--	40134826(+)	`AAGGCG/AGTGCA`	7	--	ut3¹		2		WA	120
rs6447449^1,2	C,A,H	--	40135270(+)	`cggacG/Atggtg`	7	--	ut3¹		4		NS EA	418
rs35789166^1,2	C,F	--	40135351(+)	`CGTGGA/C/TGAAAC`	14	--	ut3¹		3		NA	6
rs78199801^1,2		--	40135548(+)	`AAGCAA/CTATGA`	7	--	ut3¹		0	--	--	--	--
rs7665366^1,2	A	--	40136658(+)	`CAAACA/GGAGGA`	7	--	ut3¹		0	--	--	--	--
rs7671375^1,2	A	--	40136799(+)	`ATGGGC/TCTAAT`	7	--	ut3¹		0	--	--	--	--
rs114737743^1,2	C	--	40137110(+)	`ATTTTG/TCCTTT`	7	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for APBB2 (40812044 - 41062044 bp, first 250kb of APBB2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for APBB2
     2 CNVs: 4390 31169
     2 Indels: 12441 59202
     1 Inversion: 59795

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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APBB2 for disorders           About GeneDecksing

OMIM gene information: 602710
OMIM disorders: 104300
6 diseases for APBB2:    About MalaCards

alzheimer's disease pharyngitis atherosclerosis cerebritis

cholesterol neuronitis

1 Novoseek disease relationship for APBB2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	47.5	2	9585438 (1), 18852029 (1)

Genetic Association Database (GAD): APBB2
Human Genome Epidemiology (HuGE) Navigator: APBB2 (4 documents)

Export disorders for APBB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for APBB2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with APBB2)

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Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. (PubMed id 15714520)^{1, 4, 9} Li Y....Grupe A. (2005)
Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein. (PubMed id 9585438)^{1, 3, 9} Blanco G....McLoughlin D.M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. (PubMed id 8855266)^{1, 2} Guenette S.Y.... Tanzi R.E. (1996)
The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. (PubMed id 8955346)^{1, 3} McLoughlin D.M. and Miller C.C. (1996)
Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1. (PubMed id 14527950)^{1, 9} Chang Y....Guenette S.Y. (2003)
Analysis of APBB2 gene polymorphisms in sporadic Alzheimer's disease. (PubMed id 18852029)^{1, 9} Golanska E....Liberski P.P. (2008)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 323	HGNC: 582	AceView: APBB2	Ensembl:ENSG00000163697	euGenes: HUgn323
ECgene: APBB2	H-InvDB: APBB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for APBB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for APBB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for APBB2 gene:
Search GeneIP for patents involving APBB2

GeneCards and IP:
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