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APBB2 Gene

protein-coding GIFtS: 63

GC04M040510

amyloid beta (A4) precursor protein-binding, family B, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp434E033 ^²
FE65L ^¹, ², ³
FE65L1 ^¹, ², ³, ⁵
Fe65-like ^²
MGC35575 ^¹, ²

Descriptions
Fe65-like protein ^³
amyloid beta (A4) precursor protein-binding, family B, member 2 ^²
amyloid beta A4 precursor protein-binding, family B, member 2 ^²
amyloid beta precursor protein-binding, family B, member 2 ^¹

External Ids
HGNC: 582¹
Entrez Gene: 323²
UniProtKB: Q92870³
Ensembl: ENSG00000163697⁷

Search outside databases for aliases for APBB2 gene

Previous GC identifers: GC04M040883 GC04M041100 GC04M040666 GC04M040732 GC04M040657

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for APBB2:

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4)

precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two

phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.

[provided by RefSeq]

UniProtKB/Swiss-Prot: APBB2_HUMAN, Q92870

Function: May modulate the internalization of beta-amyloid precursor protein

Gene Wiki entry for APBB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the APBB2 gene

Entrez Gene cytogenetic band: 4p14-p13 Ensembl cytogenetic band: 4p13 HGNC cytogenetic band: 4p13

APBB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M040510: (about GC identifiers)

Start:	40,510,996 bp from pter
End:	40,911,245 bp from pter
Size:	400,250 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_006238.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: APBB2_HUMAN, Q92870 (See protein sequence)

Recommended Name: Amyloid beta A4 precursor protein-binding family B member 2

Size: 758 amino acids; 83346 Da

Subunit: Binds to the intracellular domain of the beta-amyloid precursor protein

Secondary accessions: Q8IUI6

Alternative splicing: 2 isoforms: Q92870-1 Q92870-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_775098.2

ENSEMBL proteins:

ENSP00000318965 ENSP00000295974

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (APBB2)
	Human Recombinant Proteins from Abnova (APBB2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0016020	membrane	NAS	8855266
GO:0030027	lamellipodium	ISS	--
GO:0030426	growth cone	ISS	--
GO:0045202	synapse	ISS	--

About this table

Antibodies for APBB2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for APBB2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (APBB2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (APBB2)
	Novus Biologicals Antibodies for APBB2

Assays for APBB2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q92870

ProtoNet protein and cluster: Q92870

1 Blocks protein family: IPB006020 Phosphotyrosine interaction domain

UniProtKB/Swiss-Prot: APBB2_HUMAN, Q92870

Similarity: Contains 2 PID domains

Similarity: Contains 1 WW domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (APBB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (APBB2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173075

Applied Biosystems Silencer® siRNAs for APBB2

Sigma-Aldrich siRNA for APBB2

Sigma-Aldrich shRNA for APBB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_173075
Myc/DDK tagged cDNA clone in CMV expression vector: NM_173075
untagged cDNA clone in CMV expression vector: NM_173075

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_173075

UniProtKB/Swiss-Prot: APBB2_HUMAN, Q92870

Function: May modulate the internalization of beta-amyloid precursor protein

Genatlas biochemistry entry for APBB2:

amyloid beta (A4) precursor binding protein B2,murine homolog of Fe65 like gene

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Apbb2):

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001540	beta-amyloid binding	ISS	--
GO:0008134	transcription factor binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for APBB2

5/11 Interacting proteins for APBB2 (Q92870^{1, 2} ENSP00000318965³) via UniProtKB, MINT, and/or STRING (see all 11 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APP	P05067¹, ENSP00000284981³	EBI-79277, EBI-77613 STRING (score=.994)
APLP2	Q06481¹, ENSP00000263574³	EBI-79277, EBI-79306 STRING (score=.989)
EGFR	P00533²	MINT-74472 MINT-74471 MINT-74474 MINT-74473
APLP1	ENSP00000221891³	STRING (score=.944)
APBA2	ENSP00000219865³	STRING (score=.938)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007050	cell cycle arrest	ISS	--
GO:0007242	intracellular signaling cascade	NAS	8855266
GO:0030308	negative regulation of cell growth	ISS	--
GO:0045449	regulation of transcription	ISS	--
GO:0045749	negative regulation of S phase of mitotic cell cycle	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for APBB2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (APBB2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (APBB2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173075

Sigma-Aldrich siRNA for APBB2

Sigma-Aldrich shRNA for APBB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_173075

REFSEQ mRNAs for APBB2 gene:

NM_173075.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_173075

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173075
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_173075
                                 untagged cDNA clone in CMV expression vector: NM_173075

Additional cDNA sequence:

AK024871.1 AK226179.1 AK289838.1 AK295974.1 AK299800.1 AK304247.1 AL080130.1 BC027946.1

BC088372.1 CR607261.1 CR620312.1 CR621132.1

18 DOTS entries:

DT.455435 DT.306651 DT.100805276 DT.100810565 DT.121255262 DT.97767831 DT.99935411 DT.100028433

DT.100805280 DT.91697646 DT.95366170 DT.121255397 DT.121255407 DT.121255448 DT.75120714 DT.95183247

DT.99971214 DT.40281203

24/236 AceView cDNA sequences (see all 236 ):

NM_173075 BF223603 BM705373 BG023881 CD724004 BM142507 AL600779 BX394412

BC027946 AW874579 CD171921 Z39250 BQ718072 BQ925153 BM722912 BM023404

AI400246 T48927 AA866113 BU552516 AI919212 AL080130 AI242691 CR621132

highest scoring ESTs for APBB2:

AA976074 AL582952 AL596608 BI769270 BI918204 AA016163 AA374714 AA448591 AA496214 AA496226

Unigene Cluster for APBB2:

Amyloid beta (A4) precursor protein-binding, family B, member 2

Hs.479602 [show with all ESTs]

Unigene Representative Sequence: NM_173075

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for APBB2 (see all 8 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15	^	16	^	17	^	18	^	19	^	20	^
SP1:					-																				-		-												-
SP2:																									-														-
SP3:																									-
SP4:					-								-
SP5:											-

ExUns:	21a	·	21b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for APBB2

2 Ensembl transcripts including schematic representations:

ENST00000316212 ENST00000295974

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

APBB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for APBB2

¹ / ² / ³

16 probe-sets matching APBB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40530_at²^{, 3}	U95-A	1	1.00	1.00	0.65	0.79	AL080130	0.40	1.00	0.76	1
67956_at²^{, 3}	U95-E	1	1.00	1.00	0.62	0.46	AI795836	0.60	1.00	0.82	1
40148_at²^{, 3}	U133-A	1	1.00	1.00	0.77	1.18	U62325	0.80	0.81	0.81	1
84073_at²^{, 3}	U95-E	1	0.88	1.00	0.87	1.70	AA976074	0.80	1.00	0.91	1
213419_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U62325	0.80	0.81	0.81	1
212985_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF115739	0.40	1.00	0.76	1
216750_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK024871	0.40	0.67	0.55	1
40148_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U62325	0.80	0.81	0.81	1
212970_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI694303	0.40	1.00	0.76	1
212972_x_at²^{, 3}	U133-A	46	1.00	0.77	--	--	AL080130	0.40	1.00	0.76	1
213419_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212985_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216750_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
40148_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212970_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212972_x_at²	U133Plus2	46	1.00	0.77	--	--	--	--	--	--	--

GeneDecks APBB2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCTACAGCTG

SOURCE GeneReport for Unigene cluster: Hs.479602
Expression variation in blood from EXPOLDB for APBB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for APBB2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	APBB2¹	--	amyloid beta (A4) precursor protein-binding, family more	91.53(n) 94.43(a)	488831 XM_857954.1 XP_863047.1
chimpanzee (Pan troglodytes)	APBB2¹	--	amyloid beta (A4) precursor protein-binding, family more	99.41(n) 99.86(a)	461184 XM_001146547.1 XP_001146547.1
cow (Bos taurus)	APBB2¹	--	amyloid beta (A4) precursor protein-binding, family more	90.83(n) 94.28(a)	514013 NM_001076847.1 NP_001070315.1
rat (Rattus norvegicus)	Apbb2¹	--	amyloid beta (A4) precursor protein-binding, family more	87.39(n) 91.99(a)	305338 XM_223399.4 XP_223399.4
mouse (Mus musculus)	Apbb2^{1, 5}	5⁵	amyloid beta (A4) precursor protein-binding, family more^{1, 5}	88.9(n)¹ 94.02(a)¹	11787¹ NM_009686.1¹ NP_033816.1¹ AF133665⁵ AK004792⁵ (see all 32)

About this table Species with no ortholog for APBB2

ENSEMBL Gene Tree for APBB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for APBB2 gene

APBB3² APBB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2852 NCBI SNPs in APBB2 are shown (see all 2852 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 794)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs13518^1,2	A,C,F,H,O	40510025(-)	`GTATTA/CTCTTT`	1	--	ut3¹		9		MN NA EU EA WA	930
	rs13115636^1,2	A,C,F,H	40912003(+)	`GTAAAC/TGGTAA`	1	--	ng3¹		4		EU EA WA	418
	rs4861358^1,2	A,C,F,H	40710656(+)	`TGCCTT/CGGTTC`	1	Q/R	mis¹ ese³		11		NA EU EA WA	974
	rs11940114^1,2	A,C,F,H	40911306(+)	`ACGGGC/TTCCGG`	1	--	ut5¹		8		EU EA WA	838
	rs11731472^1,2	C,F,H	40508471(+)	`GATACT/CCCAAT`	1	--	ut3¹		3		EA WA	254
	rs6447449^1,2	A,C,H	40508067(+)	`cggacG/Atggtg`	1	--	ut3¹		4		EU EA WA	418
	rs4861314^1,2	C,F,H	40507426(+)	`CTTATT/CGTATT`	1	--	ut3¹		10		NA EU EA WA	832
	rs12642508^1,2	C,H	40522696(+)	`AGTACT/CGCACG`	1	R/Q	mis¹		4		EU EA WA	406
--	rs10010101^1,2	C	40911888(+)	`GGAGAA/GATACA`	1	--	ng3¹ trp³		0	--	--	--	--
--	rs13119394^1,2	A	40911432(+)	`CGGGGA/CGGGGG`	1	--	ng3¹ tfbs³ trp³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for APBB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602710 disorders: 104300

1 Novoseek disease relationship for APBB2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	48.75	2	9585438 (1), 18852029 (1)

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1 PharmGKB disease relationship for APBB2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

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Genetic Association Database: APBB2
Human Genome Epidemiology Navigator: APBB2 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/14 PubMed articles for APBB2 gene (see all 14 ):

Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. (PubMed id 15714520)^{1, 3, 6} Li Y....Grupe A. (2005)
Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein. (PubMed id 9585438)^{1, 2, 3} Blanco G....McLoughlin D.M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. (PubMed id 8855266)^{3, 4} Guenette S.Y.... Tanzi R.E. (1996)
The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. (PubMed id 8955346)^{2, 3} McLoughlin D.M. and Miller C.C. (1996)
Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1. (PubMed id 14527950)^{1, 3} Chang Y....Guenette S.Y. (2003)
Analysis of APBB2 gene polymorphisms in sporadic Alzheimer's disease. (PubMed id 18852029)^{1, 3} Golanska E....Liberski P.P. (2008)
Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. (PubMed id 17567906)³ Hong Q....Chang N.S. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor. (PubMed id 16083851)³ Lange A....Adam D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 323	HGNC: 582	AceView: APBB2	Ensembl:ENSG00000163697	euGenes: HUgn323
ECgene: APBB2	H-InvDB: APBB2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for APBB2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for APBB2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for APBB2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for APBB2		Antibodies for APBB2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for APBB2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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APBB2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for APBB2

Summaries
for APBB2

Genomic Location
for APBB2

Proteins
for APBB2

Protein Domains/
Families
for APBB2

Gene Function
for APBB2

Pathways & Interactions
for APBB2

Drugs & Compounds
for APBB2

Transcripts
for APBB2

Expression
for APBB2

Orthologs
for APBB2

Paralogs
for APBB2

SNPs/Variants
for APBB2

Disorders & Mutations
for APBB2

Medical News
for APBB2

Publications
for APBB2

Search for APBB2

Genome Databases showing APBB2

Other Databases showing APBB2

Specialized Databases showing APBB2

Licensable Technologies
for APBB2

Services
for APBB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

APBB2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor APBB2

Summariesfor APBB2

Genomic Locationfor APBB2

Proteinsfor APBB2

Protein Domains/Familiesfor APBB2

Gene Functionfor APBB2

Pathways & Interactionsfor APBB2

Drugs & Compoundsfor APBB2

Transcriptsfor APBB2

Expression for APBB2

Orthologsfor APBB2

Paralogsfor APBB2

SNPs/Variantsfor APBB2

Disorders & Mutationsfor APBB2

Medical Newsfor APBB2

Publicationsfor APBB2

Search for APBB2

Genome Databases showing APBB2

Other Databases showing APBB2

Specialized Databases showing APBB2

Licensable Technologiesfor APBB2

Servicesfor APBB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for APBB2

Summaries
for APBB2

Genomic Location
for APBB2

Proteins
for APBB2

Protein Domains/
Families
for APBB2

Gene Function
for APBB2

Pathways & Interactions
for APBB2

Drugs & Compounds
for APBB2

Transcripts
for APBB2

Expression
for APBB2

Orthologs
for APBB2

Paralogs
for APBB2

SNPs/Variants
for APBB2

Disorders & Mutations
for APBB2

Medical News
for APBB2

Publications
for APBB2

Licensable Technologies
for APBB2

Services
for APBB2