Free for academic non-profit institutions. Other users need a Commercial license

Aliases for APBB1IP Gene

Aliases for APBB1IP Gene

  • Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein 2 3
  • Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 1 Interacting Protein 2 3 5
  • Retinoic Acid-Responsive Proline-Rich Protein 1 3 4
  • Rap1-GTP-Interacting Adaptor Molecule 2 3
  • Rap1-GTP-Interacting Adapter Molecule 3 4
  • APBB1-Interacting Protein 1 3 4
  • Proline-Rich EVH1 Ligand 1 3 4
  • Proline-Rich Protein 73 3 4
  • PREL-1 3 4
  • RARP-1 3 4
  • PREL1 3 4
  • RARP1 3 4
  • RIAM 3 4
  • Rap1-Interacting Adaptor Molecule 3
  • Proline Rich EVH1 Ligand 1 3
  • INAG1 3

External Ids for APBB1IP Gene

Previous GeneCards Identifiers for APBB1IP Gene

  • GC10P026877
  • GC10P026731
  • GC10P026767

Summaries for APBB1IP Gene

GeneCards Summary for APBB1IP Gene

APBB1IP (Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein) is a Protein Coding gene. Among its related pathways are Platelet activation and Interleukin-3, 5 and GM-CSF signaling. An important paralog of this gene is GRB14.

UniProtKB/Swiss-Prot for APBB1IP Gene

  • Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.

Gene Wiki entry for APBB1IP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APBB1IP Gene

Genomics for APBB1IP Gene

Regulatory Elements for APBB1IP Gene

Enhancers for APBB1IP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APBB1IP on UCSC Golden Path with GeneCards custom track

Promoters for APBB1IP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APBB1IP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the APBB1IP gene promoter:

Genomic Location for APBB1IP Gene

26,438,203 bp from pter
26,567,879 bp from pter
129,677 bases
Plus strand

Genomic View for APBB1IP Gene

Genes around APBB1IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APBB1IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APBB1IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APBB1IP Gene

Proteins for APBB1IP Gene

  • Protein details for APBB1IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
    Protein Accession:
    Secondary Accessions:
    • Q8IWS8
    • Q8IYL7
    • Q8IZZ7

    Protein attributes for APBB1IP Gene

    666 amino acids
    Molecular mass:
    73183 Da
    Quaternary structure:
    • Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.

    Three dimensional structures from OCA and Proteopedia for APBB1IP Gene

    Alternative splice isoforms for APBB1IP Gene


neXtProt entry for APBB1IP Gene

Proteomics data for APBB1IP Gene at MOPED

Post-translational modifications for APBB1IP Gene

  • Ubiquitination at Lys 190, Lys 268, Lys 397, and Lys 421
  • Modification sites at PhosphoSitePlus

Other Protein References for APBB1IP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for APBB1IP (RIAM/APBB1IP)
  • Abcam antibodies for RIAM
  • Cloud-Clone Corp. Antibodies for APBB1IP
  • Santa Cruz Biotechnology (SCBT) Antibodies for APBB1IP

No data available for DME Specific Peptides for APBB1IP Gene

Domains & Families for APBB1IP Gene

Gene Families for APBB1IP Gene

Protein Domains for APBB1IP Gene

Graphical View of Domain Structure for InterPro Entry



  • The two Pro-rich regions are required for the suppression of AP1 transcription activity.
  • Belongs to the MRL family.
  • The two Pro-rich regions are required for the suppression of AP1 transcription activity.
  • Contains 1 PH domain.
  • Contains 1 Ras-associating domain.
  • Belongs to the MRL family.
genes like me logo Genes that share domains with APBB1IP: view

Function for APBB1IP Gene

Molecular function for APBB1IP Gene

UniProtKB/Swiss-Prot Function:
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
UniProtKB/Swiss-Prot Induction:
By all-trans-retinoic acid (ATRA).
genes like me logo Genes that share phenotypes with APBB1IP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APBB1IP Gene

Localization for APBB1IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for APBB1IP Gene

Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for APBB1IP Gene COMPARTMENTS Subcellular localization image for APBB1IP gene
Compartment Confidence
cytosol 5
cytoskeleton 4
plasma membrane 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for APBB1IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042101 T cell receptor complex IEA --
genes like me logo Genes that share ontologies with APBB1IP: view

Pathways & Interactions for APBB1IP Gene

SuperPathways for APBB1IP Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Integrin alphaIIb beta3 signaling
3 Developmental Biology
4 Platelet activation, signaling and aggregation
5 Immune System
genes like me logo Genes that share pathways with APBB1IP: view

Pathways by source for APBB1IP Gene

Gene Ontology (GO) - Biological Process for APBB1IP Gene


No data available for SIGNOR curated interactions for APBB1IP Gene

Drugs & Compounds for APBB1IP Gene

No Compound Related Data Available

Transcripts for APBB1IP Gene

Unigene Clusters for APBB1IP Gene

Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APBB1IP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: -
SP4: - -

Relevant External Links for APBB1IP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APBB1IP Gene

mRNA expression in normal human tissues for APBB1IP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APBB1IP Gene

This gene is overexpressed in Whole Blood (x26.3).

Protein differential expression in normal tissues from HIPED for APBB1IP Gene

This gene is overexpressed in Lymph node (23.1), Peripheral blood mononuclear cells (13.9), and NK cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for APBB1IP Gene

SOURCE GeneReport for Unigene cluster for APBB1IP Gene Hs.310421

mRNA Expression by UniProt/SwissProt for APBB1IP Gene

Tissue specificity: Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
genes like me logo Genes that share expression patterns with APBB1IP: view

Protein tissue co-expression partners for APBB1IP Gene

- Elite partner

Primer Products

Orthologs for APBB1IP Gene

This gene was present in the common ancestor of animals.

Orthologs for APBB1IP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia APBB1IP 35
  • 84.22 (n)
  • 84.43 (a)
  • 86 (a)
(Canis familiaris)
Mammalia APBB1IP 35
  • 85.74 (n)
  • 85.28 (a)
  • 85 (a)
(Mus musculus)
Mammalia Apbb1ip 35
  • 79.39 (n)
  • 79.39 (a)
Apbb1ip 16
Apbb1ip 36
  • 80 (a)
(Pan troglodytes)
Mammalia APBB1IP 35
  • 99.15 (n)
  • 98.5 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Apbb1ip 35
  • 82.59 (n)
  • 84.76 (a)
(Monodelphis domestica)
Mammalia APBB1IP 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia APBB1IP 36
  • 76 (a)
(Gallus gallus)
Aves APBB1IP 35
  • 72.65 (n)
  • 73.49 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia APBB1IP 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia apbb1ip 35
  • 66.67 (n)
  • 66.16 (a)
(Danio rerio)
Actinopterygii apbb1ip 35
  • 62.63 (n)
  • 60.96 (a)
zgc63968 35
apbb1ip 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta pico 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea mig-10 36
  • 25 (a)
Species with no ortholog for APBB1IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APBB1IP Gene

Gene Tree for APBB1IP (if available)
Gene Tree for APBB1IP (if available)

Paralogs for APBB1IP Gene

Paralogs for APBB1IP Gene

(1) SIMAP similar genes for APBB1IP Gene using alignment to 3 proteins: Pseudogenes for APBB1IP Gene

genes like me logo Genes that share paralogs with APBB1IP: view

Variants for APBB1IP Gene

Sequence variations from dbSNP and Humsavar for APBB1IP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs34081356 - 26,560,159(-) TCTTG(C/T)GTCAT reference, missense
rs7903226 - 26,567,336(+) actcc(A/G)ccAGG reference, missense
rs1537746 -- 26,437,677(+) ACATA(C/T)AAGCC upstream-variant-2KB
rs1537747 -- 26,462,576(+) TGTAT(A/T)CTTGG intron-variant
rs1537748 -- 26,462,654(+) CATCT(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APBB1IP Gene

Variant ID Type Subtype PubMed ID
nsv894975 CNV Gain 21882294
esv2734362 CNV Deletion 23290073
esv2669291 CNV Deletion 23128226
esv2477507 CNV Deletion 19546169
esv2129666 CNV Deletion 18987734
esv4688 CNV Deletion 18987735
esv2734373 CNV Deletion 23290073
esv9007 CNV Loss 19470904
nsv24111 CNV Loss 16902084
nsv520311 CNV Gain 19592680
nsv523178 CNV Loss 19592680
esv272659 CNV Insertion 20981092
esv269930 CNV Insertion 20981092
esv2734384 CNV Deletion 23290073

Variation tolerance for APBB1IP Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for APBB1IP Gene

Disorders for APBB1IP Gene

Relevant External Links for APBB1IP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for APBB1IP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APBB1IP Gene

Publications for APBB1IP Gene

  1. RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. (PMID: 15469846) Lafuente E.M. … Boussiotis V.A. (Dev. Cell 2004) 3 4 23 67
  2. The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells. (PMID: 14530287) Inagaki T. … Hashizume K. (J. Biol. Chem. 2003) 3 23
  3. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. (PMID: 9407065) Ermekova K.S. … Sudol M. (J. Biol. Chem. 1997) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for APBB1IP Gene

Sources for APBB1IP Gene