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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APBB1IP Gene

protein-coding   GIFtS: 56
GCID: GC10P026767

amyloid beta (A4) precursor protein-binding, family B, member...
 Explore 4 diseases affiliated with
APBB1IP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for APBB1IP    

Aliases
for APBB1IP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 1 Interacting
Protein1 2
     PREL12 3
RIAM1 2 3     RARP-12 3
INAG11 2     RARP12 3
Proline-Rich EVH1 Ligand 12 3     APBB1-Interacting Protein 12 3
Proline-Rich Protein 732 3     Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein2
Rap1-GTP-Interacting Adapter Molecule2 3     Proline Rich EVH1 Ligand 12
Retinoic Acid-Responsive Proline-Rich Protein 12 3     Rap1-GTP-Interacting Adaptor Molecule2
PREL-12 3     Rap1-Interacting Adaptor Molecule2

External Ids:    HGNC: 173791   Entrez Gene: 545182   Ensembl: ENSG000000774207   OMIM: 6090365   UniProtKB: Q7Z5R63   

Export aliases for APBB1IP gene to outside databases

Previous GC identifers: GC10P026462 GC10P026877 GC10P026731


Summaries
for APBB1IP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: AB1IP_HUMAN, Q7Z5R6
Function: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling.
Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion

Gene Wiki entry for APBB1IP


Genomic Views
for APBB1IP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APBB1IP gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APBB1IP promoter sequence
   Search SABiosciences Chromatin IP Primers for APBB1IP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APBB1IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.1

APBB1IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APBB1IP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P026767:  view genomic region     (about GC identifiers)

Start:
 26,727,132 bp from pter      End:
 26,856,732 bp from pter
Size:
 129,601 bases      Orientation:
 plus strand

Proteins
for APBB1IP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AB1IP_HUMAN, Q7Z5R6 (See protein sequence)
Recommended Name: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein  
Size: 666 amino acids; 73183 Da
Subunit: Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1,
VASP and ENAH
Subcellular location: Cell membrane; Peripheral membrane protein (By similarity). Cell projection, lamellipodium (By
similarity). Cell junction, focal adhesion (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes
with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane
surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This
binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity)
1 PDB 3D structure from and Proteopedia for APBB1IP:
3ZDL (3D)    
Secondary accessions: Q8IWS8 Q8IZZ7

Explore the universe of human proteins at neXtProt for APBB1IP: NX_Q7Z5R6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z5R6

    • APBB1IP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061916.3  
    ENSEMBL proteins: 
     ENSP00000365411   ENSP00000432337   ENSP00000349237  
    Reactome Protein details: Q7Z5R6
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: APBB1IP
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    Novus Biologicals APBB1IP Proteins
    Novus Biologicals APBB1IP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for APBB1IP

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0005925focal adhesion IEA--
    GO:0030027lamellipodium IEA--


    APBB1IP for ontologies           About GeneDecksing



    APBB1IP Antibody Products: 
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    Uscn ELISAs and CLIAs for APBB1IP

    Protein Domains /
    Families
    for APBB1IP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    APBB1IP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry Q7Z5R6

    ProtoNet protein and cluster: Q7Z5R6

    1 Blocks protein family: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: AB1IP_HUMAN, Q7Z5R6
    Domain: The two Pro-rich regions are required for the suppression of AP1 transcription activity
    Similarity: Belongs to the MRL family
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-associating domain


    Function
    for APBB1IP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AB1IP_HUMAN, Q7Z5R6
    Function: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling.
    Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion
    Induction: By all-trans-retinoic acid (ATRA)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APBB1IP
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate APBB1IP:
    hsa-miR-3163 hsa-miR-548p hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmid: APBB1IP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APBB1IP (see all 4)
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APBB1IP (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APBB1IP 

    Cell Line
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    Search LifeMap BioReagents cell lines for APBB1IP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APBB1IP

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005543phospholipid binding IEA--


    APBB1IP for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for APBB1IP:
     Abundance of large cells with   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 


    Pathways & Interactions
    for APBB1IP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GRB2:SOS provides linkage to MAPK signaling for Intergrins
    		GRB2:SOS provides linkage to MAPK signaling for Intergrins 1.00
    		SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow0.41
    		p130Cas linkage to MAPK signaling for integrins0.76
    		SHC1 dissociates from integrin alphaIIb beta30.41
    2Platelet activation, signaling and aggregation
    		Platelet activation, signaling and aggregation1.00
    		Hemostasis0.43
    3Integrin alphaIIb beta3 signaling
    		Integrin alphaIIb beta3 signaling1.00
    		Platelet Aggregation (Plug Formation)0.73
    4Signaling by GPCR
    		Signal Transduction0.56
    5ECM-receptor interaction
    		Integrin cell surface interactions0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/10        Reactome Pathways for APBB1IP (see all 10)
        Hemostasis
    Integrin cell surface interactions
    p130Cas linkage to MAPK signaling for integrins
    GRB2:SOS provides linkage to MAPK signaling for Intergrins
    Platelet Aggregation (Plug Formation)



    APBB1IP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APBB1IP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/590 Interacting proteins for APBB1IP (Q7Z5R62, 3 ENSP000003654114) via UniProtKB, MINT, STRING, and/or I2D (see all 590)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-7945693 I2D: score=2 
    VASPP505522, 3, ENSP000002459324MINT-7945693 I2D: score=2 STRING: ENSP00000245932
    ENAHQ8N8S72, 3, ENSP000003558094MINT-7945693 I2D: score=1 STRING: ENSP00000355809
    GAS7O608613, ENSP000003226084I2D: score=2 STRING: ENSP00000322608
    PFN1P077373, ENSP000002256554I2D: score=2 STRING: ENSP00000225655
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--


    APBB1IP for ontologies           About GeneDecksing



    Drugs & Compounds
    for APBB1IP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APBB1IP
    Search CenterWatch for drugs/clinical trials and news about APBB1IP / AB1IP 

    Transcripts
    for APBB1IP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APBB1IP gene: 
    NM_019043.3  

    Unigene Cluster for APBB1IP:

    Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
    Hs.310421  [show with all ESTs]
    Unigene Representative Sequence: AK303597
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376236(uc009xks.1 uc001iss.3) ENST00000490118 ENST00000356785(uc001isr.3)
    ENST00000493857

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate APBB1IP:
    hsa-miR-3163 hsa-miR-548p hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmid: APBB1IP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APBB1IP (see all 4)
    OriGene shRNA RFP: APBB1IP
    OriGene siRNA: APBB1IP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APBB1IP
    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APBB1IP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APBB1IP

    Additional cDNA sequence: 

    AB085852.1 AK000812.1 AK303597.1 AK308916.1 AY152730.1 BC035636.1 BC054516.1 

    8 DOTS entries:

    DT.86839994  DT.40125254  DT.100741680  DT.121267015  DT.100654254  DT.101969292  DT.95079611  DT.86855973 

    24/65 AceView cDNA sequences (see all 65):

    BE676380 AI991375 BX422029 CK819672 BM129748 AA768739 AB085852 CR597342 
    AA419597 AA811421 AI093231 AA486698 AI373199 BM930926 AI475995 BC054516 
    AI796737 BM556115 BX404735 AL559802 AA436479 CK819671 AA828414 BQ642148 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for APBB1IP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                            -                                                                           
    SP2:                                            -                                                                           
    SP3:                                                                                                                        
    SP4:                                            -                       -                                                   


    ECgene alternative splicing isoforms for APBB1IP

    Expression
    for APBB1IP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APBB1IP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTTTAACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    APBB1IP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See APBB1IP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APBB1IP

    SOURCE GeneReport for Unigene cluster: Hs.310421

    UniProtKB/Swiss-Prot: AB1IP_HUMAN, Q7Z5R6
    Tissue specificity: Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral
    leukocytes

        SABiosciences Custom PCR Arrays for APBB1IP
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    In Situ
    Assay Products:     
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    Orthologs
    for APBB1IP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for APBB1IP gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Apbb1ip1 , 5 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein less1, 5 81.59(n)1
    81.94(a)1    		   2 (15.15 cM)5
    545191  NM_019456.21  NP_062329.21 
     227740945 
    chicken
    (Gallus gallus)    		 Aves APBB1IP1 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein less 68.39(n)
    69.59(a)    		   420492  NM_001006357.2  NP_001006357.2 
    lizard
    (Anolis carolinensis)    		 Reptilia APBB1IP6
    		 --
    		 60(a)
    		 1 ↔ 1
    		 6(14710219-14741227)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc639682 hypothetical protein MGC63968 74.55(n)   393607  BC057421.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta pico6
    		 pico
    		 14(a)
    		 1 → many
    		 X(19724248-19746092)
    worm
    (Caenorhabditis elegans)    		 Secernentea mig-106
    		 Abnormal cell migration protein 10
    		 19(a)
    		 1 → many
    		 III(8279037-8305761)


    ENSEMBL Gene Tree for APBB1IP (if available)
    TreeFam Gene Tree for APBB1IP (if available) 

    Paralogs
    for APBB1IP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APBB1IP gene
    GRB72  GRB102  RAPH12  GRB142  
    1 SIMAP similar gene for APBB1IP using alignment to 4 protein entries:     AB1IP_HUMAN (see all proteins):
    RAPH1

    APBB1IP for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for APBB1IP
    PGOHUM00000238376 PGOHUM00000238701


    Genomic Variants
    for APBB1IP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2362 NCBI SNPs in APBB1IP are shown (see all 2362)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1807512281,2
    		--26725353(+) ACTCTC/TATTGT 1 -- us2k10--------
    rs13355521,2
    		C,F,A,H,--26725355(+) TCTCAC/TTGTTT 1 -- us2k1 tfbs330Minor allele frequency- T:0.29EA NS NA WA 2980
    rs1438267421,2
    		--26725454(+) TCCCAA/GATAGC 1 -- us2k10--------
    rs1844463711,2
    		--26725512(+) CTCCCA/GTCTCA 1 -- us2k10--------
    rs1905382041,2
    		--26725529(+) TCAGCC/TGTACT 1 -- us2k10--------
    rs576921281,2
    		C--26725612(+) GCCTG-/GAATATT 1 -- us2k11Minor allele frequency- GA:0.00NA 2
    rs1465394011,2
    		C,--26725612(+) GCCTG-/GAATATT 1 -- us2k10--------
    rs2016607511,2
    		C--26725613(-) AATATC/TCNNNN 1 -- us2k10--------
    rs1385796841,2
    		--26725648(+) TAATCC/TCTCAT 1 -- us2k10--------
    rs1819820741,2
    		--26726114(+) AACCAC/TGAATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for APBB1IP (26727132 - 26856732 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for APBB1IP
         1 CNV: 100901
         6 Indels: 60996 39734 43052 39735 44729 11464

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    Disorders / Diseases
    for APBB1IP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APBB1IP for disorders           About GeneDecksing

    OMIM gene information: 609036    OMIM disorders: --

    4 diseases for APBB1IP:    About MalaCards
    alzheimer's disease    pharyngitis    melanoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: APBB1IP (3 documents)

    Export disorders for APBB1IP gene to outside databases

    Publications
    for APBB1IP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APBB1IP gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with APBB1IP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. (PubMed id 15469846)1, 2, 9 Lafuente E.M.... Boussiotis V.A. (2004)
    2. The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells. (PubMed id 14530287)1, 2, 9 Inagaki T.... Hashizume K. (2003)
    3. PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. (PubMed id 15642358)1, 2 Jenzora A.... Stradal T.E. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. (PubMed id 9407065)1, 3 Ermekova K.S....Sudol M. (1997)
    7. A genome-wide association study of inflammatory biomar ker changes in response to fenofibrate treatment in the Genetics of Lipid Loweri ng Drug and Diet Network. (PubMed id 22228203)1 Aslibekyan S....Arnett D.K. (2012)
    8. Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)1 Turner S.T....Boerwinkle E. (2012)
    9. Rap1-interacting adapter molecule (RIAM) associates wi th the plasma membrane via a proximity detector. (PubMed id 23045549)1 Wynne J.P....Philips M.R. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for APBB1IP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing APBB1IP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54518 HGNC: 17379 AceView: APBB1IP Ensembl:ENSG00000077420 euGenes: HUgn54518
    ECgene: APBB1IP H-InvDB: APBB1IP

    Other Databases showing APBB1IP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing APBB1IP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APBB1IP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for APBB1IP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for APBB1IP gene:
    Search GeneIP for patents involving APBB1IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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