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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APBB1IP Gene

protein-coding   GIFtS: 60
GCID: GC10P026767

Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member...

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 1
Interacting Protein1 2
     RARP-12 3
Rap1-GTP-Interacting Adaptor Molecule1 2     RARP12 3
Proline-Rich EVH1 Ligand 12 3     RIAM2 3
Proline-Rich Protein 732 3     APBB1-Interacting Protein 12 3
Rap1-GTP-Interacting Adapter Molecule2 3     INAG12
Retinoic Acid-Responsive Proline-Rich Protein 12 3     Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting
Protein2
PREL-12 3     Proline Rich EVH1 Ligand 12
PREL12 3     Rap1-Interacting Adaptor Molecule2

External Ids:    HGNC: 173791   Entrez Gene: 545182   Ensembl: ENSG000000774207   OMIM: 6090365   UniProtKB: Q7Z5R63   

Export aliases for APBB1IP gene to outside databases

Previous GC identifers: GC10P026462 GC10P026877 GC10P026731


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for APBB1IP Gene: 
APBB1IP (amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein) is a protein-coding gene. Diseases associated with APBB1IP include alzheimer's disease, and melanoma, and among its related super-pathways are p130Cas linkage to MAPK signaling for integrins and Platelet Aggregation (Plug Formation). GO annotations related to this gene include phospholipid binding. An important paralog of this gene is GRB7.

UniProtKB/Swiss-Prot: AB1IP_HUMAN, Q7Z5R6
Function: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling.
Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion

Gene Wiki entry for APBB1IP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APBB1IP gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPBB1IP promoter sequence
   Search SABiosciences Chromatin IP Primers for APBB1IP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APBB1IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.1   Ensembl cytogenetic band:  10p12.1   HGNC cytogenetic band: 10p12.1

APBB1IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APBB1IP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P026767:  view genomic region     (about GC identifiers)

Start:
26,727,132 bp from pter      End:
26,856,732 bp from pter
Size:
129,601 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AB1IP_HUMAN, Q7Z5R6 (See protein sequence)
Recommended Name: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein  
Size: 666 amino acids; 73183 Da
Subunit: Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A,
PFN1, TLN1, VASP, VCL and ENAH
Subcellular location: Cell membrane; Peripheral membrane protein (By similarity). Cell projection, lamellipodium
(By similarity). Cell junction, focal adhesion (By similarity). Cytoplasm, cytoskeleton (By similarity).
Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading
edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates,
PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to
Ras-GTPases (By similarity)
1 PDB 3D structure from and Proteopedia for APBB1IP:
3ZDL (3D)    
Secondary accessions: Q8IWS8 Q8IZZ7

Explore the universe of human proteins at neXtProt for APBB1IP: NX_Q7Z5R6

Explore proteomics data for APBB1IP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z5R6

  • APBB1IP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APBB1IP Protein Expression
    REFSEQ proteins: NP_061916.3  
    ENSEMBL proteins: 
     ENSP00000365411   ENSP00000349237  
    Reactome Protein details: Q7Z5R6
    Human Recombinant Protein Products for APBB1IP: 
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    Cloud-Clone Corp. Proteins for APBB1IP 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0005925focal adhesion IEA--
    GO:0030027lamellipodium IEA--

    APBB1IP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry Q7Z5R6

    ProtoNet protein and cluster: Q7Z5R6

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: AB1IP_HUMAN, Q7Z5R6
    Domain: The two Pro-rich regions are required for the suppression of AP1 transcription activity
    Similarity: Belongs to the MRL family
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-associating domain


    APBB1IP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AB1IP_HUMAN, Q7Z5R6
    Function: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling.
    Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion
    Induction: By all-trans-retinoic acid (ATRA)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    APBB1IP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for APBB1IP:
     Abundance of large cells with   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for APBB1IP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APBB1IP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APBB1IP 
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    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate APBB1IP:
    hsa-miR-3163 hsa-miR-548p hsa-miR-493*
    SwitchGear 3'UTR luciferase reporter plasmidAPBB1IP 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APBB1IP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GRB2:SOS provides linkage to MAPK signaling for Intergrins
    GRB2:SOS provides linkage to MAPK signaling for Intergrins 0.76
    p130Cas linkage to MAPK signaling for integrins0.76
    2Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    Platelet Aggregation (Plug Formation)0.73
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Signaling by GPCR
    Signal Transduction0.55
    5Non-integrin membrane-ECM interactions
    Integrin cell surface interactions0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/8        Reactome Pathways for APBB1IP (see all 8)
        Hemostasis
    Integrin cell surface interactions
    p130Cas linkage to MAPK signaling for integrins
    GRB2:SOS provides linkage to MAPK signaling for Intergrins
    Platelet Aggregation (Plug Formation)



    APBB1IP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APBB1IP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/618 Interacting proteins for APBB1IP (Q7Z5R62, 3 ENSP000003654114) via UniProtKB, MINT, STRING, and/or I2D (see all 618)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-7945693 I2D: score=2 
    VASPP505522, 3, ENSP000002459324MINT-7945693 I2D: score=2 STRING: ENSP00000245932
    ENAHQ8N8S72, 3, ENSP000003558094MINT-7945693 I2D: score=1 STRING: ENSP00000355809
    GAS7O608613, ENSP000003226084I2D: score=2 STRING: ENSP00000322608
    PFN1P077373, ENSP000002256554I2D: score=2 STRING: ENSP00000225655
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--

    APBB1IP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APBB1IP (AB1IP)

    Search CenterWatch for drugs/clinical trials and news about APBB1IP / AB1IP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APBB1IP gene: 
    NM_019043.3  

    Unigene Cluster for APBB1IP:

    Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
    Hs.310421  [show with all ESTs]
    Unigene Representative Sequence: AK303597
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376236(uc009xks.1 uc001iss.3) ENST00000356785(uc001isr.3)
    ENST00000493857

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate APBB1IP:
    hsa-miR-3163 hsa-miR-548p hsa-miR-493*
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB085852.1 AK000812.1 AK303597.1 AK308916.1 AY152730.1 BC035636.1 BC054516.1 

    8 DOTS entries:

    DT.86839994  DT.40125254  DT.100741680  DT.121267015  DT.100654254  DT.101969292  DT.95079611  DT.86855973 

    24/65 AceView cDNA sequences (see all 65):

    AI796737 BM556115 BX404735 CR597342 AA768739 AA419597 AI991375 BM129748 
    CK819672 AI373199 BE676380 AI475995 BM930926 AA486698 AI093231 BX422029 
    BC054516 AA811421 AB085852 NM_019043 BP382268 BX457195 BI909303 AL551807 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for APBB1IP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                            -                                                                           
    SP2:                                            -                                                                           
    SP3:                                                                                                                        
    SP4:                                            -                       -                                                   


    ECgene alternative splicing isoforms for APBB1IP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APBB1IP expression in normal human tissues (normalized intensities)      APBB1IP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTAACC
    APBB1IP Expression
    About this image


    APBB1IP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             neutrophils   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             lung ; macrophages   
             bronchoalveolar lavage cells   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   

    See APBB1IP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APBB1IP

    SOURCE GeneReport for Unigene cluster: Hs.310421

    UniProtKB/Swiss-Prot: AB1IP_HUMAN, Q7Z5R6
    Tissue specificity: Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and
    peripheral leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APBB1IP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for APBB1IP gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apbb1ip1 , 5 amyloid beta (A4) precursor protein-binding, family more1, 5 81.59(n)1
    81.94(a)1
      2 (15.15 cM)5
    545191  NM_019456.21  NP_062329.21 
     227740945 
    chicken
    (Gallus gallus)
    Aves APBB1IP1 amyloid beta (A4) precursor protein-binding, family more 68.39(n)
    69.59(a)
      420492  NM_001006357.2  NP_001006357.2 
    lizard
    (Anolis carolinensis)
    Reptilia APBB1IP6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    6(14710219-14758328)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639682 hypothetical protein MGC63968 74.55(n)   393607  BC057421.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pico6
    pico
    15(a)
    1 → many
    X(19724248-19746092)
    worm
    (Caenorhabditis elegans)
    Secernentea mig-106
    Abnormal cell migration protein 10
    23(a)
    1 → many
    III(8279108-8305832)


    ENSEMBL Gene Tree for APBB1IP (if available)
    TreeFam Gene Tree for APBB1IP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APBB1IP gene
    GRB72  RAPH12  GRB102  GRB142  
    1 SIMAP similar gene for APBB1IP using alignment to 3 protein entries:     AB1IP_HUMAN (see all proteins):
    RAPH1

    APBB1IP for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for APBB1IP
    PGOHUM00000238376 PGOHUM00000238701


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2777 SNPs in APBB1IP are shown (see all 2777)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs569029341,2
    C--26463041(+) AAAAA-/A/AA  
            
    GTGTC
    1 -- int10--------
    rs1807512281,2
    --26725353(+) ACTCTC/TATTGT 1 -- us2k10--------
    rs13355521,2
    C,F,A,H--26725355(+) TCTCAC/TTGTTT 1 -- us2k1 tfbs330Minor allele frequency- T:0.29EA NS NA WA 2980
    rs1438267421,2
    C--26725454(+) TCCCAA/GATAGC 1 -- us2k10--------
    rs1844463711,2
    --26725512(+) CTCCCA/GTCTCA 1 -- us2k10--------
    rs1905382041,2
    --26725529(+) TCAGCC/TGTACT 1 -- us2k10--------
    rs356097961,2
    C--26725612(+) GCCTG-/GAATATT 1 -- us2k11Minor allele frequency- GA:0.00NA 2
    rs2016607511,2
    C--26725613(-) AATATC/TCNNNN 1 -- us2k10--------
    rs1385796841,2
    C--26725648(+) TAATCC/TCTCAT 1 -- us2k10--------
    rs1819820741,2
    --26726114(+) AACCAC/TGAATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for APBB1IP (26727132 - 26856732 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for APBB1IP (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2129666CNV Deletion18987734
    esv2734384CNV Deletion23290073
    esv4688CNV Deletion18987735
    esv2734362CNV Deletion23290073
    esv2477507CNV Deletion19546169
    esv2734373CNV Deletion23290073
    esv2669291CNV Deletion23128226
    esv272659CNV Insertion20981092
    esv269930CNV Insertion20981092
    nsv523178CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609036    OMIM disorders: --

    2 diseases for APBB1IP:    About MalaCards
    alzheimer's disease    melanoma


    APBB1IP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): APBB1IP
    Human Genome Epidemiology (HuGE) Navigator: APBB1IP (3 documents)

    Export disorders for APBB1IP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APBB1IP gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with APBB1IP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. (PubMed id 15469846)1, 2, 9 Lafuente E.M.... Boussiotis V.A. (2004)
    2. The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells. (PubMed id 14530287)1, 2, 9 Inagaki T.... Hashizume K. (2003)
    3. A genome-wide association study of inflammatory biomar ker changes in response to fenofibrate treatment in the Genetics of Lipid Loweri ng Drug and Diet Network. (PubMed id 22228203)1, 4 Aslibekyan S....Arnett D.K. (2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (2007)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. (PubMed id 15642358)1, 2 Jenzora A.... Stradal T.E. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    10. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. (PubMed id 9407065)1, 3 Ermekova K.S....Sudol M. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54518 HGNC: 17379 AceView: APBB1IP Ensembl:ENSG00000077420 euGenes: HUgn54518
    ECgene: APBB1IP H-InvDB: APBB1IP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APBB1IP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APBB1IP gene:
    Search GeneIP for patents involving APBB1IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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