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Aliases for APBB1IP Gene

Aliases for APBB1IP Gene

  • Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 1 Interacting Protein 2 3
  • Retinoic Acid-Responsive Proline-Rich Protein 1 3 4
  • Rap1-GTP-Interacting Adaptor Molecule 2 3
  • Rap1-GTP-Interacting Adapter Molecule 3 4
  • APBB1-Interacting Protein 1 3 4
  • Proline-Rich EVH1 Ligand 1 3 4
  • Proline-Rich Protein 73 3 4
  • PREL-1 3 4
  • RARP-1 3 4
  • PREL1 3 4
  • RARP1 3 4
  • RIAM 3 4
  • Amyloid Beta A4 Precursor Protein-Binding Family B Member 1-Interacting Protein 3
  • Rap1-Interacting Adaptor Molecule 3
  • Proline Rich EVH1 Ligand 1 3
  • INAG1 3

External Ids for APBB1IP Gene

Summaries for APBB1IP Gene

GeneCards Summary for APBB1IP Gene

APBB1IP (Amyloid Beta (A4) Precursor Protein-Binding, Family B, Member 1 Interacting Protein) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is GRB14.

UniProtKB/Swiss-Prot for APBB1IP Gene

  • Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.

Gene Wiki entry for APBB1IP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APBB1IP Gene

Genomics for APBB1IP Gene

Genomic Location for APBB1IP Gene

26,438,203 bp from pter
26,567,803 bp from pter
129,601 bases
Plus strand

Genomic View for APBB1IP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APBB1IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APBB1IP Gene

Regulatory Elements for APBB1IP Gene

Transcription factor binding sites by QIAGEN in the APBB1IP gene promoter:

Proteins for APBB1IP Gene

  • Protein details for APBB1IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
    Protein Accession:
    Secondary Accessions:
    • Q8IWS8
    • Q8IYL7
    • Q8IZZ7

    Protein attributes for APBB1IP Gene

    666 amino acids
    Molecular mass:
    73183 Da
    Quaternary structure:
    • Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.

    Three dimensional structures from OCA and Proteopedia for APBB1IP Gene

    Alternative splice isoforms for APBB1IP Gene


neXtProt entry for APBB1IP Gene

Proteomics data for APBB1IP Gene at MOPED

Post-translational modifications for APBB1IP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys190, Lys268, Lys397, and Lys421

Other Protein References for APBB1IP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for APBB1IP Gene

Domains for APBB1IP Gene

Gene Families for APBB1IP Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for APBB1IP Gene


  • The two Pro-rich regions are required for the suppression of AP1 transcription activity:
    • Q7Z5R6
  • Contains 1 PH domain.:
    • Q7Z5R6
  • Contains 1 Ras-associating domain.:
    • Q7Z5R6
  • Belongs to the MRL family.:
    • Q7Z5R6
genes like me logo Genes that share domains with APBB1IP: view

Function for APBB1IP Gene

Molecular function for APBB1IP Gene

UniProtKB/Swiss-Prot Function: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
UniProtKB/Swiss-Prot Induction: By all-trans-retinoic acid (ATRA)

Gene Ontology (GO) - Molecular Function for APBB1IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24705354
genes like me logo Genes that share ontologies with APBB1IP: view
genes like me logo Genes that share phenotypes with APBB1IP: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APBB1IP Gene

Localization for APBB1IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for APBB1IP Gene

Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for APBB1IP Gene COMPARTMENTS Subcellular localization image for APBB1IP gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for APBB1IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IEA --
GO:0030027 lamellipodium IEA --
genes like me logo Genes that share ontologies with APBB1IP: view

Pathways for APBB1IP Gene

genes like me logo Genes that share pathways with APBB1IP: view

Gene Ontology (GO) - Biological Process for APBB1IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with APBB1IP: view

Transcripts for APBB1IP Gene

Unigene Clusters for APBB1IP Gene

Amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APBB1IP Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: -
SP4: - -

Relevant External Links for APBB1IP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APBB1IP Gene

mRNA expression in normal human tissues for APBB1IP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APBB1IP Gene

This gene is overexpressed in Whole Blood (26.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APBB1IP Gene

SOURCE GeneReport for Unigene cluster for APBB1IP Gene Hs.310421

mRNA Expression by UniProt/SwissProt for APBB1IP Gene

Tissue specificity: Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
genes like me logo Genes that share expressions with APBB1IP: view

Orthologs for APBB1IP Gene

This gene was present in the common ancestor of animals.

Orthologs for APBB1IP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APBB1IP 36
  • 99.15 (n)
  • 98.5 (a)
  • 99 (a)
(Bos Taurus)
Mammalia APBB1IP 36
  • 84.22 (n)
  • 84.43 (a)
  • 86 (a)
(Canis familiaris)
Mammalia APBB1IP 36
  • 85.74 (n)
  • 85.28 (a)
  • 85 (a)
(Mus musculus)
Mammalia Apbb1ip 36
  • 79.39 (n)
  • 79.39 (a)
Apbb1ip 16
Apbb1ip 37
  • 80 (a)
(Monodelphis domestica)
Mammalia APBB1IP 37
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia APBB1IP 37
  • 76 (a)
(Rattus norvegicus)
Mammalia Apbb1ip 36
  • 82.59 (n)
  • 84.76 (a)
(Gallus gallus)
Aves APBB1IP 36
  • 72.65 (n)
  • 73.49 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia APBB1IP 37
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia apbb1ip 36
  • 66.67 (n)
  • 66.16 (a)
(Danio rerio)
Actinopterygii apbb1ip 36
  • 62.63 (n)
  • 60.96 (a)
apbb1ip 37
  • 54 (a)
zgc63968 36
fruit fly
(Drosophila melanogaster)
Insecta pico 37
  • 17 (a)
(Caenorhabditis elegans)
Secernentea mig-10 37
  • 25 (a)
Species with no ortholog for APBB1IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for APBB1IP Gene

Gene Tree for APBB1IP (if available)
Gene Tree for APBB1IP (if available)

Paralogs for APBB1IP Gene

Paralogs for APBB1IP Gene

Selected SIMAP similar genes for APBB1IP Gene using alignment to 3 proteins: Pseudogenes for APBB1IP Gene

genes like me logo Genes that share paralogs with APBB1IP: view

Variants for APBB1IP Gene

Sequence variations from dbSNP and Humsavar for APBB1IP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2281 -- 26,442,372(+) ACAGC(C/T)GGCTA intron-variant
rs697158 -- 26,478,712(-) tccct(A/T)ggtgc intron-variant
rs697159 -- 26,478,419(-) catga(A/G)acacc intron-variant
rs702987 -- 26,563,191(-) ATGTA(A/G)CTCTT intron-variant
rs702988 -- 26,525,523(-) ACCAC(A/G)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APBB1IP Gene

Variant ID Type Subtype PubMed ID
nsv894975 CNV Gain 21882294
esv2734362 CNV Deletion 23290073
esv2669291 CNV Deletion 23128226
esv2477507 CNV Deletion 19546169
esv2129666 CNV Deletion 18987734
esv4688 CNV Deletion 18987735
esv2734373 CNV Deletion 23290073
esv9007 CNV Loss 19470904
nsv24111 CNV Loss 16902084
nsv520311 CNV Gain 19592680
nsv523178 CNV Loss 19592680
esv272659 CNV Insertion 20981092
esv269930 CNV Insertion 20981092
esv2734384 CNV Deletion 23290073

Relevant External Links for APBB1IP Gene

HapMap Linkage Disequilibrium report

Disorders for APBB1IP Gene

Relevant External Links for APBB1IP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with APBB1IP: view

No data available for UniProtKB/Swiss-Prot for APBB1IP Gene

Publications for APBB1IP Gene

  1. The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells. (PMID: 14530287) Inagaki T. … Hashizume K. (J. Biol. Chem. 2003) 3 4 23
  2. RIAM, an Ena/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. (PMID: 15469846) Lafuente E.M. … Boussiotis V.A. (Dev. Cell 2004) 3 4 23
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. (PMID: 15642358) Jenzora A. … Stradal T.E. (FEBS Lett. 2005) 3 4

Products for APBB1IP Gene

Sources for APBB1IP Gene

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