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APBA3 Gene

protein-coding   GIFtS: 57
GCID: GC19M003750

Amyloid Beta (A4) Precursor Protein-Binding, Family A, Member...

  See APBA3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Amyloid Beta (A4) Precursor Protein-Binding, Family A, Member 31 2     Amyloid Beta (A4) Precursor Protein-Binding, Family A, Member 3 (X11-Like
2)2
X11L22 3 5     Amyloid Beta A4 Precursor Protein-Binding Family A Member 32
Adapter Protein X11gamma2 3     mint-32
Neuron-Specific X11L2 Protein2 3     mint32
Neuronal Munc18-1-Interacting Protein 32 3     Phosphotyrosine-Binding/-Interacting Domain (PTB)-Bearing Protein2
MINT33 5     X11-Like 2 Protein2
X11-Like 21     Mint-33
MGC:158152     

External Ids:    HGNC: 5801   Entrez Gene: 95462   Ensembl: ENSG000000111327   OMIM: 6042625   UniProtKB: O960183   

Export aliases for APBA3 gene to outside databases

Previous GC identifers: GC19M003843 GC19M003690 GC19M003701 GC19M003515


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APBA3 Gene:
The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts
with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal
transduction processes. This gene is a candidate gene for Alzheimer's disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for APBA3 Gene:
APBA3 (amyloid beta (A4) precursor protein-binding, family A, member 3) is a protein-coding gene. Diseases associated with APBA3 include melanotic neuroectodermal tumor. GO annotations related to this gene include beta-amyloid binding and enzyme binding. An important paralog of this gene is APBA2.

UniProtKB/Swiss-Prot: APBA3_HUMAN, O96018
Function: May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May
enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN

Gene Wiki entry for APBA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APBA3 gene promoter:
         Max1   NF-1/L   NF-1   p300   AP-2gamma   PPAR-gamma1   AP-2beta   PPAR-gamma2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPBA3 promoter sequence
   Search Chromatin IP Primers for APBA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APBA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

APBA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APBA3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003750:  view genomic region     (about GC identifiers)

Start:
3,750,771 bp from pter      End:
3,761,697 bp from pter
Size:
10,927 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: APBA3_HUMAN, O96018 (See protein sequence)
Recommended Name: Amyloid beta A4 precursor protein-binding family A member 3  
Size: 575 amino acids; 61454 Da
Subunit: Binds to the cytoplasmic domain of amyloid protein (APP) in vivo. Interacts with HIF1AN (via N-terminus)
2 PDB 3D structures from and Proteopedia for APBA3:
2YT7 (3D)        2YT8 (3D)    
Secondary accessions: O60483 Q9UPZ2

Explore the universe of human proteins at neXtProt for APBA3: NX_O96018

Explore proteomics data for APBA3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See APBA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004877.1  
    ENSEMBL proteins: 
     ENSP00000315136  

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    antibodies-online proteins for APBA3 (7 products) 

     
    antibodies-online peptides for APBA3

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    antibodies-online antibodies for APBA3 (41 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR001478 PDZ
     IPR006020 PTB/PI_dom

    Graphical View of Domain Structure for InterPro Entry O96018

    ProtoNet protein and cluster: O96018

    2 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: APBA3_HUMAN, O96018
    Domain: Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding
    with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to
    attach proteins to the plasma membrane
    Similarity: Contains 2 PDZ (DHR) domains
    Similarity: Contains 1 PID domain


    Find genes that share domains with APBA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APBA3_HUMAN, O96018
    Function: May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May
    enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN

         Genatlas biochemistry entry for APBA3:
    amyloid beta (A4) precursor protein binding,family A,member 3 (X11-like 2),expressed in various tissues

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IEA--
    GO:0004857enzyme inhibitor activity IDA19726677
    GO:0005515protein binding IPI10049767
    GO:0019899enzyme binding IPI19726677
         
    Find genes that share ontologies with APBA3           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Apba3):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     no phenotypic analysis  normal 

    Find genes that share phenotypes with APBA3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for APBA3: Apba3tm1.1Sud Apba3tm1.2Ski

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APBA3
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    hsa-mir-615-3p (MIRT040391), hsa-mir-100-5p (MIRT048517)

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    4 qRT-PCR Assays for microRNAs that regulate APBA3:
    hsa-miR-124 hsa-miR-506 hsa-miR-128 hsa-miR-3681*
    SwitchGear 3'UTR luciferase reporter plasmidAPBA3 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APBA3_HUMAN, O96018: Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0048471perinuclear region of cytoplasm IDA19726677

    Find genes that share ontologies with APBA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including APBA3: 
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for APBA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for APBA3 (O960181, 2, 3 ENSP000003151364) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCRP112742, 3, ENSP000003035074MINT-69545 MINT-69538 MINT-69541 MINT-69543 MINT-69544 I2D: score=3 STRING: ENSP00000303507
    TANKQ928441, 3, ENSP000002590754EBI-6115839,EBI-356349 I2D: score=1 STRING: ENSP00000259075
    TBKBP1A7MCY61, 3, ENSP000003547774STRING: ENSP00000354777 EBI-6115839,EBI-359969 I2D: score=1 
    EGFRP005332, 3, ENSP000002754934MINT-74464 I2D: score=2 STRING: ENSP00000275493
    APPP050673, ENSP000002849814I2D: score=4 STRING: ENSP00000284981
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0007268synaptic transmission IEA--
    GO:0010468regulation of gene expression IEA--
    GO:0015031protein transport IEA--
    GO:0035556intracellular signal transduction ----

    Find genes that share ontologies with APBA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APBA3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APBA3 gene: 
    NM_004886.3  

    Unigene Cluster for APBA3:

    Amyloid beta (A4) precursor protein-binding, family A, member 3
    Hs.465607  [show with all ESTs]
    Unigene Representative Sequence: AB209603
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588984 ENST00000590064 ENST00000316757(uc002lyo.1 uc002lyp.1)
    ENST00000591678 ENST00000586991 ENST00000592826 ENST00000590238 ENST00000589934

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    hsa-miR-124 hsa-miR-506 hsa-miR-128 hsa-miR-3681*
    SwitchGear 3'UTR luciferase reporter plasmidAPBA3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB021638.1 AB209603.1 AF029110.1 BC086306.1 

    8 DOTS entries:

    DT.95273579  DT.87014942  DT.100025307  DT.100025306  DT.100756467  DT.40131720  DT.91914121  DT.95273578 

    Selected AceView cDNA sequences (see all 93):

    CR623670 CK299463 CD674507 AB021638 AA346833 BE549738 BE274973 BU069794 
    AW135383 BM553060 BI918185 BU624296 BM009160 NM_004886 BQ943727 BG656365 
    BM020252 BG490654 BQ129290 AL548770 AI652439 BX426746 BG938715 BG488505 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APBA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCGGAGC
    APBA3 Expression
    About this image

    APBA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APBA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465607

    UniProtKB/Swiss-Prot: APBA3_HUMAN, O96018
    Tissue specificity: Expressed in all tissues examined with lower levels in brain and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including APBA3: 
              Alzheimer's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for APBA3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apba31 , 5 amyloid beta (A4) precursor protein-binding, family A, member 3 less1, 5 76.77(n)1
    76.71(a)1
      10 (39.72 cM)5
    572671  NM_018758.21  NP_061228.11 
     812681725 
    chicken
    (Gallus gallus)
    Aves APBA31 amyloid beta (A4) precursor protein-binding, family A, member 3 less 67.68(n)
    64.31(a)
      420069  XM_418188.4  XP_418188.3 
    lizard
    (Anolis carolinensis)
    Reptilia APBA36
    amyloid beta (A4) precursor protein-binding, famil...
    64(a)
    1 ↔ 1
    AAWZ02041380(2101-4518)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.106672 Xenopus laevis transcribed sequence with weak similarity to protein pirA47176 (H.sapiens) A47176 probable transmembrane protein X11 - human (fragment) less 73.92(n)    BJ627951.1 
    zebrafish
    (Danio rerio)
    Actinopterygii APBA36
    amyloid beta (A4) precursor protein-binding, famil...
    38(a)
    1 ↔ 1
    11(5651987-5667430) ENSDARG00000090675
    fruit fly
    (Drosophila melanogaster)
    Insecta X11L6
    X11Lbeta6
    X11Lbeta
    20(a)
    11(a)
    many ↔ many
    many ↔ many
    X(17493641-17500912)
    X(10521770-10604900)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-103 Phosphotyrosine interaction domain
    (PTB/PID)., PDZ domain (Also known as
    DHR or GLGF). (2 domains) less
    51(a)   I(8118196-8127374)   --


    ENSEMBL Gene Tree for APBA3 (if available)
    TreeFam Gene Tree for APBA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APBA3 gene
    APBA22  APBA12  
    3 SIMAP similar genes for APBA3 using alignment to 1 protein entry:     APBA3_HUMAN:
    X11L2    APBA1    APBA2

    Find genes that share paralogs with APBA3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APBA3 (see all 338)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830530131,2
    C--3751333(+) CTGGGA/GGAGAA 1 -- int10--------
    rs3688525601,2
    C--3751378(+) GGGGCC/TGTGCT 1 -- int10--------
    rs2004403731,2
    --3751403(+) CCCCCC/TACCCC 1 -- int10--------
    rs2020682281,2
    C--3751408(+) CACCCC/TGGGGC 1 -- int10--------
    rs1150551721,2
    C,F--3751409(+) ACCCCG/AGGGCC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs2006710471,2
    C--3751431(+) CCTCAA/CGATGC 1 -- spd10--------
    rs760145511,2
    C--3751446(+) CTCCAC/TGCAGA 2 M V mis10--------
    rs1913571851,2
    C--3751467(+) CTCGCA/GGGCGT 2 R C mis10--------
    rs1120865971,2
    C,F--3751531(+) GTCACC/TGACGT 2 S syn12Minor allele frequency- T:0.00CSA NA 3404
    rs1831056701,2
    --3751593(+) GGACAA/GCCTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for APBA3 (3750771 - 3761697 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for APBA3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509718CNV Insertion20534489
    nsv910768CNV Loss21882294
    dgv3651n71CNV Loss21882294
    nsv910722CNV Loss21882294
    nsv910775CNV Loss21882294
    dgv3663n71CNV Loss21882294
    nsv470114CNV Loss18288195
    nsv910773CNV Loss21882294
    nsv910770CNV Loss21882294
    dgv3660n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604262    OMIM disorders: --

    1 disease for APBA3:    
    About MalaCards
    melanotic neuroectodermal tumor

    1 disease from the University of Copenhagen DISEASES database for APBA3:
    Melanotic neuroectodermal tumor

    Find genes that share disorders with APBA3           About GenesLikeMe

    Genetic Association Database (GAD): APBA3
    Human Genome Epidemiology (HuGE) Navigator: APBA3 (1 document)

    Export disorders for APBA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APBA3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with APBA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. X11L2, a new member of X11 protein family interacts with Alzheimer's beta-amyloid precursor protein. (PubMed id 10049767)1, 2, 3 Tanahashi H. and Tabira T. (Biochem. Biophys. Res. Commun. 1999)
    2. Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein. (PubMed id 10574372)1, 2, 9 Tanahashi H. and Tabira T. (NeuroReport 1999)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    4. Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1. (PubMed id 19726677)1, 2 Sakamoto T. and Seiki M. (J. Biol. Chem. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2. (PubMed id 9860131)1, 2 Okamoto M. and Suedhof T.C. (Eur. J. Cell Biol. 1998)
    8. Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network. (PubMed id 18544638)1, 9 Han J....Chi C. (J. Cell. Sci. 2008)
    9. Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network. (PubMed id 17959829)1, 9 Shrivastava-Ranjan P....Kahn R.A. (Mol. Biol. Cell 2008)
    10. Novel mediators of amyloid precursor protein signaling. (PubMed id 20016085)1, 9 Swistowski A....Bredesen D.E. (J. Neurosci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9546 HGNC: 580 AceView: APBA3 Ensembl:ENSG00000011132 euGenes: HUgn9546
    ECgene: APBA3 H-InvDB: APBA3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APBA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APBA3 gene:
    Search GeneIP for patents involving APBA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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