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AP5Z1 Gene

protein-coding   GIFtS: 44
GCID: GC07P004816

Adaptor-Related Protein Complex 5, Zeta 1 Subunit

(Previous name: KIAA0415)
(Previous symbol: KIAA0415)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adaptor-Related Protein Complex 5, Zeta 1 Subunit1 2     AP-5 Complex Subunit Zeta-12
KIAA04151 2 3 5     zeta2
SPG482 3 5     zeta52
Adapter-Related Protein Complex 5 Zeta Subunit2 3     Zeta53

External Ids:    HGNC: 221971   Entrez Gene: 99072   Ensembl: ENSG000002428027   OMIM: 6136535   UniProtKB: O432993   

Export aliases for AP5Z1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AP5Z1 Gene:
This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand
break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in
HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in
patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862).
(provided by RefSeq, Jan 2011)

GeneCards Summary for AP5Z1 Gene:
AP5Z1 (adaptor-related protein complex 5, zeta 1 subunit) is a protein-coding gene. Diseases associated with AP5Z1 include spastic paraplegia 48, autosomal recessive, and spastic paraplegia 48.

UniProtKB/Swiss-Prot: AP5Z1_HUMAN, O43299
Function: As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport.
According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA
double-strand break repair




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AP5Z1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): AP5Z1 promoter sequence
   Search Chromatin IP Primers for AP5Z1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP5Z1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.2   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

AP5Z1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP5Z1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P004816:  view genomic region     (about GC identifiers)

Start:
4,815,253 bp from pter      End:
4,834,026 bp from pter
Size:
18,774 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 4,861,617-4,880,381     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AP5Z1_HUMAN, O43299 (See protein sequence)
Recommended Name: AP-5 complex subunit zeta-1  
Size: 807 amino acids; 88605 Da
Subunit: Probably part of the adapter protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and
AP5Z1. Interacts with ZFYVE26 and SPG11
Sequence caution: Sequence=BAA24845.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8N3X2 Q96H80
Alternative splicing: 3 isoforms:  O43299-1   O43299-2   O43299-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AP5Z1: NX_O43299

Explore proteomics data for AP5Z1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys30, Lys178
  • Modification sites at PhosphoSitePlus

  • See AP5Z1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055670.1  
    ENSEMBL proteins: 
     ENSP00000297562   ENSP00000384980  

    AP5Z1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028222 AP5Z1

    Graphical View of Domain Structure for InterPro Entry O43299

    ProtoNet protein and cluster: O43299


    AP5Z1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP5Z1_HUMAN, O43299
    Function: As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport.
    According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA
    double-strand break repair

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    AP5Z1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AP5Z1:
     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AP5Z1
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    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AP5Z1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AP5Z1_HUMAN, O43299: Cytoplasm. Nucleus. Note=By SDS-PAGE, 2 isoforms have been observed, the shorter seems to be
    predominantly nuclear and the longer is mostly cytoplasmic (PubMed:20613862)

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0030119AP-type membrane coat adaptor complex NAS--
    GO:0044599AP-5 adaptor complex IEA--

    AP5Z1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP5Z1
    Interactions:

        Search GeneGlobe Interaction Network for AP5Z1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AP5Z1 (O432992, 3 ENSP000002975624) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-50996 I2D: score=1 STRING: ENSP00000300161
    MDFIQ997502, 3, ENSP000002303214MINT-66128 I2D: score=5 STRING: ENSP00000230321
    IRF2P143163, ENSP000003772184I2D: score=1 STRING: ENSP00000377218
    AP5M1ENSP000002615584STRING: ENSP00000261558
    AP5S1ENSP000002460414STRING: ENSP00000246041
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IMP--
    GO:0008219cell death IEA--
    GO:0015031protein transport IEA--
    GO:0016197endosomal transport IMP--

    AP5Z1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AP5Z1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AP5Z1 gene: 
    NM_014855.2  

    Unigene Cluster for AP5Z1:

    Adaptor-related protein complex 5, zeta 1 subunit
    Hs.558440  [show with all ESTs]
    Unigene Representative Sequence: NM_014855
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348624 ENST00000477680 ENST00000496303(uc003sne.3 uc010ksp.3 uc003snf.3)
    ENST00000491375 ENST00000477454 ENST00000469614 ENST00000490487 ENST00000401897

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AP5Z1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AP5Z1
    SwitchGear 3'UTR luciferase reporter plasmidAP5Z1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat AP5Z1
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat AP5Z1
      QuantiFast Probe-based Assays in human, mouse, rat AP5Z1

    Additional mRNA sequence: 

    AK092068.1 BC008841.2 BC011518.1 BC014240.2 

    4 DOTS entries:

    DT.95168629  DT.308601  DT.100787168  DT.100787172 

    Selected AceView cDNA sequences (see all 47):

    BI826032 BC038434 BQ669962 AA077104 AW205747 AI027829 AI820940 AI344304 
    AW206906 AK122663 AW297939 BF929948 BI828369 BI910532 AW469490 BE872018 
    AI125260 AI018291 BI828231 AW389254 AI660405 AI336935 AI916265 BI825326 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AP5Z1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCGGCTCT
    AP5Z1 Expression
    About this image


    AP5Z1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
    AP5Z1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AP5Z1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558440
        Custom PCR Arrays for AP5Z1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP5Z1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP5Z1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap5z11 , 5 RIKEN cDNA C330006K01 gene5
    adaptor-related protein complex 5, zeta 1 subunit1
    79.65(n)1
    78.78(a)1
      5 (81.53 cM)5
    2318551  NM_172725.21  NP_766313.21 
     1424639315 
    chicken
    (Gallus gallus)
    Aves AP5Z11 adaptor-related protein complex 5, zeta 1 subunit 65.55(n)
    58.74(a)
      416478  XM_003642113.2  XP_003642161.1 
    lizard
    (Anolis carolinensis)
    Reptilia AP5Z16
    adaptor-related protein complex 5, zeta 1 subunit
    61(a)
    1 ↔ 1
    GL343591.1(162484-176977)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004975601 AP-5 complex subunit zeta-1-like 61.93(n)
    52.45(a)
      100497560  XM_002942689.2  XP_002942735.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005379341 AP-5 complex subunit zeta-1-like 59.93(n)
    53.66(a)
      100537934  XM_005164180.1  XP_005164237.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G151601 AT3G15160 38.57(n)
    29.05(a)
      820747  NM_112379.5  NP_188134.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g06269001 Os04g0626900 39.35(n)
    28.7(a)
      4337073  NM_001060485.1  NP_001053950.1 


    ENSEMBL Gene Tree for AP5Z1 (if available)
    TreeFam Gene Tree for AP5Z1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AP5Z1 gene
    1 SIMAP similar gene for AP5Z1 using alignment to 1 protein entry:     AP5Z1_HUMAN:
    KIAA0415

    AP5Z1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AP5Z1 (see all 934)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357138351,2
    C,F--4730082(+) TAGCTT/GCCCTG 1 -- us2k19Minor allele frequency- G:0.22NA WA CSA EA 370
    rs1478580421,2
    --4784004(+) TCTCTC/TAGAAC 1 -- us2k10--------
    rs1488164821,2
    --4784107(+) AAGTAC/TGGTAC 1 -- us2k10--------
    rs108079111,2
    C,F,A,H--4784108(+) AGTACG/CGTACG 1 -- us2k128Minor allele frequency- C:0.14NS EA NA CSA WA 3178
    rs1862814841,2
    --4784323(+) ACCCCA/CGGCTC 1 -- us2k10--------
    rs1155807851,2
    C,F--4784339(+) CGTCGC/ACAATG 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1906048291,2
    --4784481(+) TTCCAC/TAGACT 1 -- us2k10--------
    rs1171454671,2
    F--4784611(+) ACCAGG/ATGCCC 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1434541491,2
    --4784755(+) CCCACC/TCTATC 1 -- us2k10--------
    rs1813131561,2
    --4784801(+) CAGAAC/TCTTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AP5Z1 (4815253 - 4834026 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AP5Z1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AP5Z1
    DNA2.0 Custom Variant and Variant Library Synthesis for AP5Z1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613653   
    OMIM disorders: 613647  
    UniProtKB/Swiss-Prot: AP5Z1_HUMAN, O43299
  • Spastic paraplegia 48, autosomal recessive (SPG48) [MIM:613647]: A form of spastic paraplegia, a
    neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower
    limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include
    difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking.
    In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness
    may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 8 diseases for AP5Z1:    
    About MalaCards
    spastic paraplegia 48, autosomal recessive    spastic paraplegia 48    paraplegia    spasticity
    hereditary spastic paraplegia    retinitis    multiple myeloma    myeloma


    AP5Z1 for disorders           About GeneDecksing


    Export disorders for AP5Z1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AP5Z1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with AP5Z1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The fifth adaptor protein complex. (PubMed id 22022230)1, 2, 3 Hirst J.... Robinson M.S. (PLoS Biol. 2011)
    2. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. (PubMed id 20613862)1, 2, 3 Slabicki M.... Buchholz F. (PLoS Biol. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1997)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9907 HGNC: 22197 AceView: FOXK1.1 Ensembl:ENSG00000242802 euGenes: HUgn9907
    ECgene: AP5Z1 H-InvDB: AP5Z1

    (According to HUGE)
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    HUGE: KIAA0415

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AP5Z1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AP5Z1 gene:
    Search GeneIP for patents involving AP5Z1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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