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Aliases for AP5M1 Gene

Aliases for AP5M1 Gene

  • Adaptor-Related Protein Complex 5, Mu 1 Subunit 2 3
  • C14orf108 3 4 6
  • MUDENG 3 4 6
  • MuD 3 4 6
  • Adaptor-Related Protein Complex 5 Subunit Mu-1 3 4
  • MU-2/AP1M2 Domain Containing, Death-Inducing 2 3
  • Putative HIV-1 Infection-Related Protein 3 4
  • Mu-2-Related Death-Inducing Protein 3 4
  • Mu5 3 4
  • Adapter-Related Protein Complex 5 Subunit Mu-1 3
  • MHD Domain-Containing Death-Inducing Protein 3
  • Adapter-Related Protein Complex 5 Mu Subunit 3
  • Chromosome 14 Open Reading Frame 108 2
  • Mu-2 Related Death-Inducing Gene 2
  • Mu-2 Related Death-Inducing 3
  • AP-5 Complex Subunit Mu-1 3
  • AP-5 Complex Subunit Mu 3

External Ids for AP5M1 Gene

Previous Symbols for AP5M1 Gene

  • C14orf108
  • MUDENG

Summaries for AP5M1 Gene

GeneCards Summary for AP5M1 Gene

AP5M1 (Adaptor-Related Protein Complex 5, Mu 1 Subunit) is a Protein Coding gene. Diseases associated with AP5M1 include hiv-1.

UniProtKB/Swiss-Prot for AP5M1 Gene

  • As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP5M1 Gene

Genomics for AP5M1 Gene

Genomic Location for AP5M1 Gene

Start:
57,268,888 bp from pter
End:
57,298,742 bp from pter
Size:
29,855 bases
Orientation:
Plus strand

Genomic View for AP5M1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AP5M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP5M1 Gene

No data available for Regulatory Elements for AP5M1 Gene

Proteins for AP5M1 Gene

  • Protein details for AP5M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0R1-AP5M1_HUMAN
    Recommended name:
    AP-5 complex subunit mu-1
    Protein Accession:
    Q9H0R1
    Secondary Accessions:
    • O95354
    • Q6ZMD7
    • Q96DX3
    • Q9NVC5

    Protein attributes for AP5M1 Gene

    Size:
    490 amino acids
    Molecular mass:
    54767 Da
    Quaternary structure:
    • Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1
    SequenceCaution:
    • Sequence=BAD18791.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18791.1; Type=Frameshift; Positions=482; Evidence={ECO:0000305};

    Alternative splice isoforms for AP5M1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP5M1 Gene

Proteomics data for AP5M1 Gene at MOPED

Post-translational modifications for AP5M1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AP5M1 Gene

No data available for DME Specific Peptides for AP5M1 Gene

Domains for AP5M1 Gene

Protein Domains for AP5M1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

AP5M1_HUMAN
Domain:
  • Contains 1 MHD (mu homology) domain.:
    • Q9H0R1
Family:
  • Belongs to the adaptor complexes medium subunit family.:
    • Q9H0R1
genes like me logo Genes that share domains with AP5M1: view

No data available for Gene Families for AP5M1 Gene

Function for AP5M1 Gene

Molecular function for AP5M1 Gene

UniProtKB/Swiss-Prot Function: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.

Gene Ontology (GO) - Molecular Function for AP5M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with AP5M1: view

miRNA for AP5M1 Gene

miRTarBase miRNAs that target AP5M1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AP5M1 Gene

Localization for AP5M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP5M1 Gene

Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=May cycle on and off membranes.

Gene Ontology (GO) - Cellular Components for AP5M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 22022230
GO:0005765 lysosomal membrane IEA --
GO:0005770 late endosome IDA 22022230
GO:0005829 cytosol IDA 22022230
GO:0016020 membrane IDA 22022230
genes like me logo Genes that share ontologies with AP5M1: view

Pathways for AP5M1 Gene

SuperPathways for AP5M1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AP5M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0016197 endosomal transport IMP 22022230
genes like me logo Genes that share ontologies with AP5M1: view

No data available for Pathways by source for AP5M1 Gene

Transcripts for AP5M1 Gene

Unigene Clusters for AP5M1 Gene

Adaptor-related protein complex 5, mu 1 subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AP5M1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5:
SP6: -

Relevant External Links for AP5M1 Gene

GeneLoc Exon Structure for
AP5M1
ECgene alternative splicing isoforms for
AP5M1

Expression for AP5M1 Gene

mRNA expression in normal human tissues for AP5M1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AP5M1 Gene

SOURCE GeneReport for Unigene cluster for AP5M1 Gene Hs.597349

mRNA Expression by UniProt/SwissProt for AP5M1 Gene

Q9H0R1-AP5M1_HUMAN
Tissue specificity: Expressed in various tumor cell lines including Jurkat, Hep-G2 and HeLa.
genes like me logo Genes that share expressions with AP5M1: view

Orthologs for AP5M1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AP5M1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP5M1 36
  • 99.73 (n)
  • 99.8 (a)
AP5M1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AP5M1 36
  • 90.48 (n)
  • 90.61 (a)
AP5M1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP5M1 36
  • 91.02 (n)
  • 91.63 (a)
AP5M1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap5m1 36
  • 86.3 (n)
  • 85.07 (a)
Ap5m1 16
Ap5m1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AP5M1 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AP5M1 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap5m1 36
  • 85.14 (n)
  • 85.07 (a)
chicken
(Gallus gallus)
Aves AP5M1 37
  • 63 (a)
OneToOne
MUDENG 36
  • 67.32 (n)
  • 64.35 (a)
lizard
(Anolis carolinensis)
Reptilia AP5M1 37
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ap5m1 36
  • 64.74 (n)
  • 61.65 (a)
Str.20418 36
zebrafish
(Danio rerio)
Actinopterygii ap5m1 36
  • 57.43 (n)
  • 57.14 (a)
ap5m1 37
  • 55 (a)
OneToOne
Dr.13330 36
Species with no ortholog for AP5M1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AP5M1 Gene

ENSEMBL:
Gene Tree for AP5M1 (if available)
TreeFam:
Gene Tree for AP5M1 (if available)

Paralogs for AP5M1 Gene

Pseudogenes.org Pseudogenes for AP5M1 Gene

genes like me logo Genes that share paralogs with AP5M1: view

No data available for Paralogs for AP5M1 Gene

Variants for AP5M1 Gene

Sequence variations from dbSNP and Humsavar for AP5M1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10883 -- 57,280,412(+) CTTCT(A/T)CACTT reference, missense, nc-transcript-variant
rs1189896 -- 57,271,689(+) TCAAA(C/G)TAGTT intron-variant
rs1189897 -- 57,272,053(+) ATAGA(C/G)GTGAA intron-variant
rs1189898 -- 57,274,075(+) AATGG(G/T)CATTA intron-variant
rs1189899 -- 57,274,832(+) ATGCA(A/G)TATGA reference, synonymous-codon, intron-variant

Relevant External Links for AP5M1 Gene

HapMap Linkage Disequilibrium report
AP5M1

No data available for Structural Variations from Database of Genomic Variants (DGV) for AP5M1 Gene

Disorders for AP5M1 Gene

(1) MalaCards Diseases for AP5M1 Gene

Search for AP5M1 Gene in MalaCards »
genes like me logo Genes that share disorders with AP5M1: view

No data available for UniProtKB/Swiss-Prot for AP5M1 Gene

Publications for AP5M1 Gene

  1. A novel protein, MUDENG, induces cell death in cytotoxic T cells. (PMID: 18395520) Lee M.-R. … Kim T.-H. (Biochem. Biophys. Res. Commun. 2008) 2 3 4
  2. The fifth adaptor protein complex. (PMID: 22022230) Hirst J. … Robinson M.S. (PLoS Biol. 2011) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for AP5M1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate AP5M1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for AP5M1
    • Block miRNA regulation of AP5M1 using miScript Target Protectors

    Sources for AP5M1 Gene

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