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Aliases for AP5M1 Gene

Aliases for AP5M1 Gene

  • Adaptor Related Protein Complex 5 Mu 1 Subunit 2 3
  • Adaptor-Related Protein Complex 5, Mu 1 Subunit 2 3
  • Adaptor Related Protein Complex 5, Mu 1 Subunit 3 5
  • Adaptor-Related Protein Complex 5 Subunit Mu-1 3 4
  • MU-2/AP1M2 Domain Containing, Death-Inducing 2 3
  • Putative HIV-1 Infection-Related Protein 3 4
  • Mu-2-Related Death-Inducing Protein 3 4
  • C14orf108 3 4
  • MUDENG 3 4
  • Mu5 3 4
  • MuD 3 4
  • Adapter-Related Protein Complex 5 Subunit Mu-1 3
  • MHD Domain-Containing Death-Inducing Protein 3
  • Adapter-Related Protein Complex 5 Mu Subunit 3
  • Chromosome 14 Open Reading Frame 108 2
  • Mu-2 Related Death-Inducing Gene 2
  • Mu-2 Related Death-Inducing 3
  • AP-5 Complex Subunit Mu 3

External Ids for AP5M1 Gene

Previous HGNC Symbols for AP5M1 Gene

  • C14orf108
  • MUDENG

Previous GeneCards Identifiers for AP5M1 Gene

  • GC14P057737

Summaries for AP5M1 Gene

GeneCards Summary for AP5M1 Gene

AP5M1 (Adaptor Related Protein Complex 5 Mu 1 Subunit) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AP5M1 Gene

  • As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP5M1 Gene

Genomics for AP5M1 Gene

Regulatory Elements for AP5M1 Gene

Promoters for AP5M1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AP5M1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AP5M1 Gene

Chromosome:
14
Start:
57,268,888 bp from pter
End:
57,298,742 bp from pter
Size:
29,855 bases
Orientation:
Plus strand

Genomic View for AP5M1 Gene

Genes around AP5M1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP5M1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP5M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP5M1 Gene

Proteins for AP5M1 Gene

  • Protein details for AP5M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0R1-AP5M1_HUMAN
    Recommended name:
    AP-5 complex subunit mu-1
    Protein Accession:
    Q9H0R1
    Secondary Accessions:
    • O95354
    • Q6ZMD7
    • Q96DX3
    • Q9NVC5

    Protein attributes for AP5M1 Gene

    Size:
    490 amino acids
    Molecular mass:
    54767 Da
    Quaternary structure:
    • Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.
    SequenceCaution:
    • Sequence=BAD18791.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18791.1; Type=Frameshift; Positions=482; Evidence={ECO:0000305};

    Alternative splice isoforms for AP5M1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP5M1 Gene

Proteomics data for AP5M1 Gene at MOPED

Post-translational modifications for AP5M1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AP5M1 Gene

No data available for DME Specific Peptides for AP5M1 Gene

Domains & Families for AP5M1 Gene

Protein Domains for AP5M1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AP5M1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0R1

UniProtKB/Swiss-Prot:

AP5M1_HUMAN :
  • Contains 1 MHD (mu homology) domain.
  • Belongs to the adaptor complexes medium subunit family.
Domain:
  • Contains 1 MHD (mu homology) domain.
Family:
  • Belongs to the adaptor complexes medium subunit family.
genes like me logo Genes that share domains with AP5M1: view

No data available for Gene Families for AP5M1 Gene

Function for AP5M1 Gene

Molecular function for AP5M1 Gene

UniProtKB/Swiss-Prot Function:
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.

Phenotypes for AP5M1 Gene

genes like me logo Genes that share phenotypes with AP5M1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AP5M1 Gene

Localization for AP5M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP5M1 Gene

Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=May cycle on and off membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP5M1 Gene COMPARTMENTS Subcellular localization image for AP5M1 gene
Compartment Confidence
cytosol 5
endosome 5
lysosome 5
vacuole 5
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AP5M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 22022230
GO:0005765 lysosomal membrane IEA --
GO:0005829 cytosol IDA 22022230
GO:0016020 membrane IDA 22022230
GO:0031902 late endosome membrane IEA --
genes like me logo Genes that share ontologies with AP5M1: view

Pathways & Interactions for AP5M1 Gene

SuperPathways for AP5M1 Gene

No Data Available

Interacting Proteins for AP5M1 Gene

Gene Ontology (GO) - Biological Process for AP5M1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AP5M1 Gene

Drugs & Compounds for AP5M1 Gene

No Compound Related Data Available

Transcripts for AP5M1 Gene

Unigene Clusters for AP5M1 Gene

Adaptor-related protein complex 5, mu 1 subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AP5M1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5:
SP6: -

Relevant External Links for AP5M1 Gene

GeneLoc Exon Structure for
AP5M1
ECgene alternative splicing isoforms for
AP5M1

Expression for AP5M1 Gene

mRNA expression in normal human tissues for AP5M1 Gene

Protein differential expression in normal tissues from HIPED for AP5M1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.4), Lymph node (19.4), Blymphocyte (16.5), and Spinal cord (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AP5M1 Gene



SOURCE GeneReport for Unigene cluster for AP5M1 Gene Hs.597349

mRNA Expression by UniProt/SwissProt for AP5M1 Gene

Q9H0R1-AP5M1_HUMAN
Tissue specificity: Expressed in various tumor cell lines including Jurkat, Hep-G2 and HeLa.
genes like me logo Genes that share expression patterns with AP5M1: view

Protein tissue co-expression partners for AP5M1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for AP5M1 Gene

Orthologs for AP5M1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AP5M1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP5M1 35
  • 99.73 (n)
  • 99.8 (a)
AP5M1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AP5M1 36
  • 90 (a)
OneToOne
AP5M1 35
  • 90.48 (n)
  • 90.61 (a)
dog
(Canis familiaris)
Mammalia AP5M1 35
  • 91.02 (n)
  • 91.63 (a)
AP5M1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap5m1 16
Ap5m1 36
  • 85 (a)
OneToOne
Ap5m1 35
  • 86.3 (n)
  • 85.07 (a)
oppossum
(Monodelphis domestica)
Mammalia AP5M1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AP5M1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap5m1 35
  • 85.14 (n)
  • 85.07 (a)
chicken
(Gallus gallus)
Aves MUDENG 35
  • 67.32 (n)
  • 64.35 (a)
AP5M1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP5M1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ap5m1 35
  • 64.74 (n)
  • 61.65 (a)
Str.20418 35
zebrafish
(Danio rerio)
Actinopterygii ap5m1 36
  • 55 (a)
OneToOne
ap5m1 35
  • 57.43 (n)
  • 57.14 (a)
Dr.13330 35
Species with no ortholog for AP5M1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AP5M1 Gene

ENSEMBL:
Gene Tree for AP5M1 (if available)
TreeFam:
Gene Tree for AP5M1 (if available)

Paralogs for AP5M1 Gene

Pseudogenes.org Pseudogenes for AP5M1 Gene

genes like me logo Genes that share paralogs with AP5M1: view

No data available for Paralogs for AP5M1 Gene

Variants for AP5M1 Gene

Sequence variations from dbSNP and Humsavar for AP5M1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10137359 - 57,274,845(+) AACAG(A/C/G)GTATA intron-variant, reference, missense
rs10140245 - 57,282,982(+) CTTGA(A/C)GTATT nc-transcript-variant, reference, missense
rs10883 -- 57,280,412(+) CTTCT(A/G/T)CACTT nc-transcript-variant, reference, missense
rs1189897 -- 57,272,053(+) ATAGA(C/G)GTGAA intron-variant
rs1189899 -- 57,274,832(+) ATGCA(A/G)TATGA intron-variant, reference, synonymous-codon

Variation tolerance for AP5M1 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AP5M1 Gene

HapMap Linkage Disequilibrium report
AP5M1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AP5M1 Gene

Disorders for AP5M1 Gene

Relevant External Links for AP5M1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AP5M1

No disorders were found for AP5M1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AP5M1 Gene

Publications for AP5M1 Gene

  1. A novel protein, MUDENG, induces cell death in cytotoxic T cells. (PMID: 18395520) Lee M.-R. … Kim T.-H. (Biochem. Biophys. Res. Commun. 2008) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. MUDENG is cleaved by caspase-3 during TRAIL-induced cell death. (PMID: 23665015) Shin J.N. … Kim T.H. (Biochem. Biophys. Res. Commun. 2013) 3
  4. The fifth adaptor protein complex. (PMID: 22022230) Hirst J. … Robinson M.S. (PLoS Biol. 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for AP5M1 Gene

Sources for AP5M1 Gene

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