Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



AP5M1 Gene

protein-coding   GIFtS: 39
GCID: GC14P057737

Adaptor-Related Protein Complex 5, Mu 1 Subunit

(Previous names: chromosome 14 open reading frame 108, MU-2/AP1M2 domain...)
(Previous symbols: C14orf108, MUDENG)
  See AP5M1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Adaptor-Related Protein Complex 5, Mu 1 Subunit1 2     Chromosome 14 Open Reading Frame 1081
C14orf1081 2 3 5     Mu-2 Related Death-Inducing Gene1
MUDENG1 2 3 5     Adapter-Related Protein Complex 5 Mu Subunit2
MU-2/AP1M2 Domain Containing, Death-Inducing1 2     AP-5 Complex Subunit Mu2
Adapter-Related Protein Complex 5 Subunit Mu-12 3     AP-5 Complex Subunit Mu-12
Mu-2-Related Death-Inducing Protein2 3     MHD Domain-Containing Death-Inducing Protein2
Putative HIV-1 Infection-Related Protein2 3     Mu-2 Related Death-Inducing2
Mu52 3     MUD5
MuD2 3     

External Ids:    HGNC: 201921   Entrez Gene: 557452   Ensembl: ENSG000000537707   OMIM: 6143685   UniProtKB: Q9H0R13   
ORGUL members:         

Export aliases for AP5M1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for AP5M1 Gene:
AP5M1 (adaptor-related protein complex 5, mu 1 subunit) is a protein-coding gene. Diseases associated with AP5M1 include hiv-1.

UniProtKB/Swiss-Prot: AP5M1_HUMAN, Q9H0R1
Function: As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport.
According to PubMed:18395520, it may play a role in cell death




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for AP5M1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAP5M1 promoter sequence
   Search Chromatin IP Primers for AP5M1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP5M1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.3   Ensembl cytogenetic band:  14q22.3   HGNC cytogenetic band: 14q22.2

AP5M1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP5M1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P057737:  view genomic region     (about GC identifiers)

Start:
57,735,606 bp from pter      End:
57,756,797 bp from pter
Size:
21,192 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AP5M1_HUMAN, Q9H0R1 (See protein sequence)
Recommended Name: AP-5 complex subunit mu-1  
Size: 490 amino acids; 54767 Da
Subunit: Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and
AP5Z1
Sequence caution: Sequence=BAD18791.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD18791.1; Type=Frameshift; Positions=482;
Secondary accessions: O95354 Q6ZMD7 Q96DX3 Q9NVC5
Alternative splicing: 2 isoforms:  Q9H0R1-1   Q9H0R1-2   (May be due to an intron retention)

Explore the universe of human proteins at neXtProt for AP5M1: NX_Q9H0R1

Explore proteomics data for AP5M1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AP5M1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060699.3  
    ENSEMBL proteins: 
     ENSP00000261558   ENSP00000452211   ENSP00000451306   ENSP00000390531   ENSP00000473837  
     ENSP00000450422  

    AP5M1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AP5M1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for AP5M1
    GenScript Custom Purified and Recombinant Proteins Services for AP5M1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for AP5M1 

    AP5M1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AP5M1
    Search for Antibodies for AP5M1 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for AP5M1
    LSBio Antibodies in human, mouse, rat for AP5M1

    AP5M1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AP5M1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AP5M1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for AP5M1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR008968 Clathrin_mu_C
     IPR028565 MHD

    Graphical View of Domain Structure for InterPro Entry Q9H0R1

    ProtoNet protein and cluster: Q9H0R1

    UniProtKB/Swiss-Prot: AP5M1_HUMAN, Q9H0R1
    Similarity: Belongs to the adaptor complexes medium subunit family
    Similarity: Contains 1 MHD (mu homology) domain


    Find genes that share domains with AP5M1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP5M1_HUMAN, Q9H0R1
    Function: As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport.
    According to PubMed:18395520, it may play a role in cell death

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with AP5M1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AP5M1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AP5M1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AP5M1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AP5M1

    miRNA
    Products:
        
    miRTarBase miRNAs that target AP5M1:
    hsa-mir-24-3p (MIRT030579), hsa-mir-193b-3p (MIRT016437)

    Block miRNA regulation of human, mouse, rat AP5M1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AP5M1
    SwitchGear 3'UTR luciferase reporter plasmidAP5M1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for AP5M1
    Predesigned siRNA for gene silencing in human, mouse, rat AP5M1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AP5M1

    Clone
    Products:
         
    OriGene clones in human, mouse for AP5M1 (see all 6)
    OriGene ORF clones in mouse, rat for AP5M1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for AP5M1
    Sino Biological Human cDNA Clone for AP5M1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP5M1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP5M1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AP5M1
    Browse ESI BIO Cell Lines and PureStem Progenitors for AP5M1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP5M1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AP5M1_HUMAN, Q9H0R1: Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side
    (Probable). Lysosome membrane; Peripheral membrane protein; Cytoplasmic side (Probable). Note=May cycle on and
    off membranes

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IDA--
    GO:0005765lysosomal membrane IEA--
    GO:0005770late endosome IDA--
    GO:0005829cytosol IDA--
    GO:0016020membrane IDA--

    Find genes that share ontologies with AP5M1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP5M1
    Interactions:

        Search GeneGlobe Interaction Network for AP5M1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AP5M1 (ENSP000002615584) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP5Z1ENSP000002975624STRING: ENSP00000297562
    AFTPHENSP000002388554STRING: ENSP00000238855
    AP1G2ENSP000003124424STRING: ENSP00000312442
    AP1S1ENSP000003366664STRING: ENSP00000336666
    AP1G1ENSP000003771484STRING: ENSP00000377148
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0016192vesicle-mediated transport IEA--
    GO:0016197endosomal transport IMP--

    Find genes that share ontologies with AP5M1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AP5M1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for AP5M1 gene: 
    NM_018229.3  

    Unigene Cluster for AP5M1:

    Adaptor-related protein complex 5, mu 1 subunit
    Hs.597349  [show with all ESTs]
    Unigene Representative Sequence: NM_018229
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261558(uc001xcv.3 uc010tri.2 uc010trj.2) ENST00000554931(uc001xcu.4)
    ENST00000556995 ENST00000555448 ENST00000431972 ENST00000554213 ENST00000556723
    ENST00000554863 ENST00000556377
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat AP5M1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate AP5M1
    SwitchGear 3'UTR luciferase reporter plasmidAP5M1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for AP5M1
    Predesigned siRNA for gene silencing in human, mouse, rat AP5M1
    Clone
    Products:
         
    OriGene clones in human, mouse for AP5M1 (see all 6)
    OriGene ORF clones in mouse, rat for AP5M1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for AP5M1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP5M1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP5M1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AP5M1
    OriGene qSTAR qPCR primer pairs in human, mouse for AP5M1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat AP5M1
      QuantiTect SYBR Green Assays in human, mouse, rat AP5M1
      QuantiFast Probe-based Assays in human, mouse, rat AP5M1

    Additional mRNA sequence: 

    AF094583.1 AK001675.1 AK172824.1 AK225345.1 AK303999.1 AL136685.1 NR_026895.1 

    11 DOTS entries:

    DT.450151  DT.95173270  DT.91794033  DT.91816126  DT.100022163  DT.99997950  DT.100815462  DT.100815465 
    DT.100815468  DT.95295138  DT.75100186 

    Selected AceView cDNA sequences (see all 261):

    AA026244 AA243269 BQ888650 BQ428448 AW083080 BC013174 AI888606 BQ954221 
    AA992484 AW293014 AI337184 BX284003 CN482562 AU132960 AI831329 AI459887 
    BM704534 AI279487 BM678696 NM_018229 AA507466 AU135787 CA428726 AA665748 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AP5M1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                                      -     -                                               -         
    SP2:                                                                                                      
    SP3:                          -     -     -     -                                                         
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for AP5M1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    AP5M1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTTTACA
    AP5M1 Expression
    About this image

    AP5M1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AP5M1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.597349

    UniProtKB/Swiss-Prot: AP5M1_HUMAN, Q9H0R1
    Tissue specificity: Expressed in various tumor cell lines including Jurkat, Hep-G2 and HeLa

        Custom PCR Arrays for AP5M1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AP5M1
    OriGene qSTAR qPCR primer pairs in human, mouse for AP5M1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat AP5M1
    QuantiTect SYBR Green Assays in human, mouse, rat AP5M1
    QuantiFast Probe-based Assays in human, mouse, rat AP5M1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP5M1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for AP5M1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap5m11 , 5 MU-2/AP1M2 domain containing, death-inducing5
    adaptor-related protein complex 5, mu 1 subunit1
    86.3(n)1
    85.07(a)1
      14 (25.36 cM)5
    743851  NM_144535.41  NP_653118.31 
     490664955 
    chicken
    (Gallus gallus)
    Aves MUDENG1 MU-2/AP1M2 domain containing, death-inducing 67.32(n)
    64.35(a)
      423548  XM_421441.3  XP_421441.2 
    lizard
    (Anolis carolinensis)
    Reptilia AP5M16
    adaptor-related protein complex 5, mu 1 subunit
    69(a)
    1 ↔ 1
    GL343325.1(926786-959293)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.204182 Transcribed sequence with weak similarity to protein more 74.13(n)    BX772144.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.133302 Transcribed sequence with weak similarity to protein more 71.13(n)    AL918219.1 


    ENSEMBL Gene Tree for AP5M1 (if available)
    TreeFam Gene Tree for AP5M1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for AP5M1 gene

    Find genes that share paralogs with AP5M1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for AP5M1
    PGOHUM00000242646


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for AP5M1 (see all 409)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1900564041,2
    --57737757(+) GAGGAA/GCTCAA 2 -- int10--------
    rs1445744071,2
    --57737844(+) ACAGTA/GCAAAT 2 -- int10--------
    rs1484537011,2
    C--57737980(+) CCTCAA/GATCTG 2 -- int10--------
    rs1166500851,2
    C--57738126(+) TTTTGC/GCAATA 2 -- int10--------
    rs1813020351,2
    --57738300(+) TTAGTC/TCTATG 2 -- int10--------
    rs107139341,2
    C--57738350(+) TGTCAA/-TTAAC 2 -- int12Minor allele frequency- -:0.00NA 4
    rs1383736021,2
    C--57738389(+) CACTA-/TATTTT 2 -- int10--------
    rs11898961,2
    C,F,A,H--57738407(+) TCAAAC/GTAGTT 2 -- int19Minor allele frequency- G:0.29NS NA WA CSA EA 487
    rs1857716131,2
    --57738679(+) CTCATA/GTAAAT 2 -- int10--------
    rs1905808661,2
    --57738721(+) TTCTTG/TTACCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for AP5M1 (57735606 - 57756797 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AP5M1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AP5M1
    DNA2.0 Custom Variant and Variant Library Synthesis for AP5M1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614368    OMIM disorders: --

    1 disease for AP5M1:    
    About MalaCards
    hiv-1


    Find genes that share disorders with AP5M1           About GenesLikeMe


    Export disorders for AP5M1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for AP5M1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with AP5M1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein, MUDENG, induces cell death in cytotoxic T cells. (PubMed id 18395520)1, 2, 3 Lee M.-R.... Kim T.-H. (Biochem. Biophys. Res. Commun. 2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    5. MUDENG is cleaved by caspase-3 during TRAIL-induced cell death. (PubMed id 23665015)1 Shin J.N....Kim T.H. (Biochem. Biophys. Res. Commun. 2013)
    6. The fifth adaptor protein complex. (PubMed id 22022230)2 Hirst J.... Robinson M.S. (PLoS Biol. 2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55745 HGNC: 20192 AceView: C14orf108 Ensembl:ENSG00000053770 euGenes: HUgn55745
    ECgene: AP5M1 H-InvDB: AP5M1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for AP5M1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AP5M1 gene:
    Search GeneIP for patents involving AP5M1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AP5M1  
     OriGene qPCR primer pairs and template standards for AP5M1   OriGene Protein Over-expression Lysate for AP5M1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AP5M1  
     OriGene qSTAR qPCR primer pairs in human, mouse for AP5M1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AP5M1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AP5M1   OriGene Custom Protein Services for AP5M1  

     
     
     Block miRNA regulation of human, mouse, rat AP5M1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing AP5M1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP5M1 Predesigned siRNA for gene silencing in human, mouse, rat AP5M1
     QuantiFast Probe-based Assays in human, mouse, rat AP5M1 QuantiTect SYBR Green Assays in human, mouse, rat AP5M1
     Custom PCR Arrays for AP5M1 Search Chromatin IP Primers for AP5M1
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat AP5M1 Search GeneGlobe Interaction Network for AP5M1
     Search Regulatory tfbs for AP5M1
     GenScript Custom Purified and Recombinant Proteins Services for AP5M1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for AP5M1
     GenScript Custom Assay Services for AP5M1 GenScript Custom overexpressing Cell Line Services for AP5M1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for AP5M1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for AP5M1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for AP5M1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for AP5M1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for AP5M1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP5M1
     SwitchGear 3'UTR luciferase reporter plasmids for AP5M1
     SwitchGear Promoter luciferase reporter plasmids for AP5M1
     Search ThermoFisher Antibodies for AP5M1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP5M1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AP5M1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for AP5M1
     LSBio Antibodies in human, mouse, rat for AP5M1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for AP5M1
      Search eBioscience for proteins for AP5M1
      Search eBioscience for elisas for AP5M1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AP5M1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4