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Aliases for AP5B1 Gene

Aliases for AP5B1 Gene

  • Adaptor Related Protein Complex 5 Beta 1 Subunit 2 3
  • Adaptor-Related Protein Complex 5, Beta 1 Subunit 2 3
  • Adaptor Related Protein Complex 5, Beta 1 Subunit 3 5
  • Adaptor-Related Protein Complex 5 Beta Subunit 3 4
  • Beta5 3 4
  • AP-5 Complex Subunit Beta 3
  • PP1030 3
  • AP-5 3

External Ids for AP5B1 Gene

Previous GeneCards Identifiers for AP5B1 Gene

  • GC11M065546

Summaries for AP5B1 Gene

GeneCards Summary for AP5B1 Gene

AP5B1 (Adaptor Related Protein Complex 5 Beta 1 Subunit) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AP5B1 Gene

  • As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP5B1 Gene

Genomics for AP5B1 Gene

Regulatory Elements for AP5B1 Gene

Promoters for AP5B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AP5B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for AP5B1 Gene

Chromosome:
11
Start:
65,773,898 bp from pter
End:
65,780,802 bp from pter
Size:
6,905 bases
Orientation:
Minus strand

Genomic View for AP5B1 Gene

Genes around AP5B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP5B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP5B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP5B1 Gene

Proteins for AP5B1 Gene

  • Protein details for AP5B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VPB7-AP5B1_HUMAN
    Recommended name:
    AP-5 complex subunit beta-1
    Protein Accession:
    Q2VPB7
    Secondary Accessions:
    • A1L0S6
    • H6WUK2
    • Q0D2Q2
    • Q8N3J7
    • Q8WYH6

    Protein attributes for AP5B1 Gene

    Size:
    878 amino acids
    Molecular mass:
    93949 Da
    Quaternary structure:
    • Probably part of the adaptor protein complex 5 (AP-5), a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with ZFYVE26 and SPG11.
    SequenceCaution:
    • Sequence=AAG22468.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAI09110.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI09111.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI26906.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI28057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW74438.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for AP5B1 Gene

Proteomics data for AP5B1 Gene at MOPED

Post-translational modifications for AP5B1 Gene

  • Ubiquitination at Lys 161, Lys 214, Lys 309, and Lys 674
  • Modification sites at PhosphoSitePlus

Other Protein References for AP5B1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AP5B1 Gene

Domains & Families for AP5B1 Gene

Protein Domains for AP5B1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with AP5B1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for AP5B1 Gene

Function for AP5B1 Gene

Molecular function for AP5B1 Gene

UniProtKB/Swiss-Prot Function:
As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.
genes like me logo Genes that share phenotypes with AP5B1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AP5B1 Gene

Localization for AP5B1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP5B1 Gene COMPARTMENTS Subcellular localization image for AP5B1 gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 2
nucleus 2
plasma membrane 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AP5B1 Gene

Pathways & Interactions for AP5B1 Gene

SuperPathways for AP5B1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AP5B1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for AP5B1 Gene

Drugs & Compounds for AP5B1 Gene

No Compound Related Data Available

Transcripts for AP5B1 Gene

mRNA/cDNA for AP5B1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AP5B1 Gene

Adaptor-related protein complex 5, beta 1 subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AP5B1 Gene

No ASD Table

Relevant External Links for AP5B1 Gene

GeneLoc Exon Structure for
AP5B1
ECgene alternative splicing isoforms for
AP5B1

Expression for AP5B1 Gene

mRNA expression in normal human tissues for AP5B1 Gene

mRNA differential expression in normal tissues according to GTEx for AP5B1 Gene

This gene is overexpressed in Whole Blood (x14.6).

Protein differential expression in normal tissues from HIPED for AP5B1 Gene

This gene is overexpressed in Liver, secretome (21.8) and Bone (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AP5B1 Gene



SOURCE GeneReport for Unigene cluster for AP5B1 Gene Hs.591957

genes like me logo Genes that share expression patterns with AP5B1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for AP5B1 Gene

Orthologs for AP5B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AP5B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP5B1 35
  • 99.28 (n)
  • 99.32 (a)
cow
(Bos Taurus)
Mammalia AP5B1 35
  • 84.46 (n)
  • 85.37 (a)
AP5B1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP5B1 36
  • 85 (a)
OneToOne
AP5B1 35
  • 83.77 (n)
  • 84.91 (a)
mouse
(Mus musculus)
Mammalia Ap5b1 16
Ap5b1 36
  • 78 (a)
OneToOne
Ap5b1 35
  • 78.91 (n)
  • 78.26 (a)
oppossum
(Monodelphis domestica)
Mammalia AP5B1 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap5b1 35
  • 78.3 (n)
  • 77.57 (a)
lizard
(Anolis carolinensis)
Reptilia AP5B1 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AP5B1 36
  • 31 (a)
OneToOne
Species with no ortholog for AP5B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AP5B1 Gene

ENSEMBL:
Gene Tree for AP5B1 (if available)
TreeFam:
Gene Tree for AP5B1 (if available)

Paralogs for AP5B1 Gene

No data available for Paralogs for AP5B1 Gene

Variants for AP5B1 Gene

Sequence variations from dbSNP and Humsavar for AP5B1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs495961 -- 65,773,415(-) ctttg(A/G)ttgga downstream-variant-500B
rs569703 -- 65,776,256(-) TCCCC(A/G)TGGGC utr-variant-3-prime
rs2508301 -- 65,774,583(-) AAAAT(A/C)CAAAA utr-variant-3-prime
rs2508302 -- 65,773,955(-) agccc(A/C/G)ccttc utr-variant-3-prime
rs2508303 -- 65,773,744(-) TCACT(G/T)CAACC downstream-variant-500B

Variation tolerance for AP5B1 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.15; 93.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AP5B1 Gene

HapMap Linkage Disequilibrium report
AP5B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AP5B1 Gene

Disorders for AP5B1 Gene

Relevant External Links for AP5B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AP5B1

No disorders were found for AP5B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AP5B1 Gene

Publications for AP5B1 Gene

  1. The fifth adaptor protein complex. (PMID: 22022230) Hirst J. … Robinson M.S. (PLoS Biol. 2011) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15. (PMID: 23825025) Hirst J. … Robinson M.S. (Mol. Biol. Cell 2013) 3
  5. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. (PMID: 20613862) Slabicki M. … Buchholz F. (PLoS Biol. 2010) 3

Products for AP5B1 Gene

Sources for AP5B1 Gene

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