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Aliases for AP5B1 Gene

Aliases for AP5B1 Gene

  • Adaptor-Related Protein Complex 5, Beta 1 Subunit 2 3
  • Adaptor-Related Protein Complex 5 Beta Subunit 3 4
  • Beta5 3 4
  • AP-5 Complex Subunit Beta-1 3
  • AP-5 Complex Subunit Beta 3
  • DKFZp761E198 6
  • PP1030 3
  • AP-5 3

External Ids for AP5B1 Gene

Summaries for AP5B1 Gene

GeneCards Summary for AP5B1 Gene

AP5B1 (Adaptor-Related Protein Complex 5, Beta 1 Subunit) is a Protein Coding gene.

UniProtKB/Swiss-Prot for AP5B1 Gene

  • As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP5B1 Gene

Genomics for AP5B1 Gene

Genomic Location for AP5B1 Gene

Start:
65,773,898 bp from pter
End:
65,780,802 bp from pter
Size:
6,905 bases
Orientation:
Minus strand

Genomic View for AP5B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AP5B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP5B1 Gene

No data available for Regulatory Elements for AP5B1 Gene

Proteins for AP5B1 Gene

  • Protein details for AP5B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VPB7-AP5B1_HUMAN
    Recommended name:
    AP-5 complex subunit beta-1
    Protein Accession:
    Q2VPB7
    Secondary Accessions:
    • A1L0S6
    • H6WUK2
    • Q0D2Q2
    • Q8N3J7
    • Q8WYH6

    Protein attributes for AP5B1 Gene

    Size:
    878 amino acids
    Molecular mass:
    93949 Da
    Quaternary structure:
    • Probably part of the adaptor protein complex 5 (AP-5), a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with ZFYVE26 and SPG11.
    SequenceCaution:
    • Sequence=AAG22468.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAI09110.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI09111.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI26906.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI28057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW74438.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for AP5B1 Gene

Proteomics data for AP5B1 Gene at MOPED

Post-translational modifications for AP5B1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys161, Lys214, Lys309, Lys674, and Lys681

Other Protein References for AP5B1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AP5B1 Gene

Domains for AP5B1 Gene

Protein Domains for AP5B1 Gene

ProtoNet:
genes like me logo Genes that share domains with AP5B1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for AP5B1 Gene

Function for AP5B1 Gene

Molecular function for AP5B1 Gene

UniProtKB/Swiss-Prot Function: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.

Gene Ontology (GO) - Molecular Function for AP5B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20613862
genes like me logo Genes that share ontologies with AP5B1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for AP5B1 Gene

Localization for AP5B1 Gene

Gene Ontology (GO) - Cellular Components for AP5B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0030119 AP-type membrane coat adaptor complex IDA 22022230
genes like me logo Genes that share ontologies with AP5B1: view

Pathways for AP5B1 Gene

SuperPathways for AP5B1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for AP5B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016197 endosomal transport IMP 22022230
genes like me logo Genes that share ontologies with AP5B1: view

No data available for Pathways by source for AP5B1 Gene

Transcripts for AP5B1 Gene

mRNA/cDNA for AP5B1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AP5B1 Gene

Adaptor-related protein complex 5, beta 1 subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AP5B1 Gene

No ASD Table

Relevant External Links for AP5B1 Gene

GeneLoc Exon Structure for
AP5B1
ECgene alternative splicing isoforms for
AP5B1

Expression for AP5B1 Gene

mRNA expression in normal human tissues for AP5B1 Gene

mRNA differential expression in normal tissues according to GTEx for AP5B1 Gene

This gene is overexpressed in Whole Blood (14.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AP5B1 Gene

SOURCE GeneReport for Unigene cluster for AP5B1 Gene Hs.591957

genes like me logo Genes that share expressions with AP5B1: view

Orthologs for AP5B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AP5B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP5B1 36
  • 99.28 (n)
  • 99.32 (a)
cow
(Bos Taurus)
Mammalia AP5B1 36
  • 84.46 (n)
  • 85.37 (a)
AP5B1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP5B1 36
  • 83.77 (n)
  • 84.91 (a)
AP5B1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap5b1 36
  • 78.91 (n)
  • 78.26 (a)
Ap5b1 16
Ap5b1 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AP5B1 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap5b1 36
  • 78.3 (n)
  • 77.57 (a)
lizard
(Anolis carolinensis)
Reptilia AP5B1 37
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AP5B1 37
  • 31 (a)
OneToOne
Species with no ortholog for AP5B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AP5B1 Gene

ENSEMBL:
Gene Tree for AP5B1 (if available)
TreeFam:
Gene Tree for AP5B1 (if available)

Paralogs for AP5B1 Gene

No data available for Paralogs for AP5B1 Gene

Variants for AP5B1 Gene

Sequence variations from dbSNP and Humsavar for AP5B1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs489574 -- 65,775,268(-) TTGTG(C/T)ATCCA utr-variant-3-prime
rs494003 -- 65,774,827(-) TCACA(C/T)GGGTC utr-variant-3-prime
rs495961 -- 65,773,415(-) ctttg(A/G)ttgga downstream-variant-500B
rs522800 -- 65,775,950(-) TCACG(C/G)CACTG utr-variant-3-prime
rs569703 -- 65,776,256(-) TCCCC(A/G)TGGGC utr-variant-3-prime

Relevant External Links for AP5B1 Gene

HapMap Linkage Disequilibrium report
AP5B1

No data available for Structural Variations from Database of Genomic Variants (DGV) for AP5B1 Gene

Disorders for AP5B1 Gene

No disorders were found for AP5B1 Gene.

No data available for UniProtKB/Swiss-Prot for AP5B1 Gene

Publications for AP5B1 Gene

  1. The fifth adaptor protein complex. (PMID: 22022230) Hirst J. … Robinson M.S. (PLoS Biol. 2011) 2 3 4
  2. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. (PMID: 20613862) Slabicki M. … Buchholz F. (PLoS Biol. 2010) 3 4
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for AP5B1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate AP5B1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for AP5B1
    • Block miRNA regulation of AP5B1 using miScript Target Protectors

    Sources for AP5B1 Gene

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