AP5B1 Gene
protein-coding GIFtS: 33
GCID: GC11M065546
|
|
adaptor-related protein complex 5, beta 1 subunit
| |
Aliases
for AP5B1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adaptor-Related Protein Complex 5, Beta 1 Subunit1 2 | | AP-5 Complex Subunit Beta-12 | | AP-51 2 | | Beta53 | | PP10301 2 | | Beta53 | | DKFZp761E1981 | | Adapter-Related Protein Complex 5 Beta Subunit3 | | AP-5 Complex Subunit Beta2 | | |
Export aliases for AP5B1 gene to outside databases |
Summaries
for AP5B1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AP5B1_HUMAN, Q2VPB7Function: As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport
|
Genomic Views
for AP5B1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for AP5B1
Other transcription factors
Search SABiosciences Chromatin IP Primers for AP5B1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP5B1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1AP5B1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M065546: view genomic region
(about GC identifiers)
Start:
|
65,543,364 bp from pter |
End:
|
65,548,273 bp from pter |
Size:
|
4,910 bases |
Orientation:
|
minus strand |
|
Proteins
for AP5B1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AP5B1_HUMAN, Q2VPB7 (See
protein sequence)Recommended Name: AP-5 complex subunit beta-1 Size: 878 amino acids; 93949 Da
Subunit: Probably part of the adapter protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.Interacts with ZFYVE26 and SPG11
Sequence caution: Sequence=AAG22468.1; Type=Miscellaneous discrepancy; Note=Sequencing errors; Sequence=AAI09110.2;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI09111.2; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=AAI26906.1; Type=Erroneous initiation; Note=Translation N-terminallyextended; Sequence=AAI28057.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW74438.1;Type=Erroneous gene model prediction;
Secondary accessions: A1L0S6 H6WUK2 Q0D2Q2 Q8N3J7 Q8WYH6Explore the universe of human proteins at neXtProt for AP5B1: NX_Q2VPB7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2VPB7
AP5B1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612377.4
ENSEMBL proteins: ENSP00000454303
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030119 | AP-type membrane coat adaptor complex |
IDA | -- |
AP5B1 for ontologies About GeneDecksing
AP5B1 Antibody Products:
Assay Products for AP5B1: |
Protein
Domains /
Families
for AP5B1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q2VPB7 |
Function
for AP5B1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AP5B1_HUMAN, Q2VPB7Function: As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP5B1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP5B1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for AP5B1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP5B1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP5B1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP5B1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
AP5B1 for ontologies About GeneDecksing
|
Pathways & Interactions
for AP5B1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AP5B1
5 Interacting proteins for AP5B1 (Q2VPB73) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | | GO:0016197 | endosomal transport |
IMP | -- |
AP5B1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AP5B1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AP5B1
Search CenterWatch for drugs/clinical trials and news about AP5B1
|
Transcripts
for AP5B1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AP5B1 gene: NM_138368.4 Unigene Cluster for AP5B1: Adaptor-related protein complex 5, beta 1 subunit Hs.591957 [show with all ESTs]Unigene Representative Sequence: NM_1383681 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000532090
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP5B1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP5B1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for AP5B1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP5B1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP5B1 |
Additional cDNA sequence: AF193040.1 AL834269.1 BC004895.2 BC017264.2 BC109109.1 BC109110.1 BC126905.1 BC128056.1 JQ313135.1 7 DOTS entries: DT.442874 DT.120741525 DT.95093894 DT.95126631 DT.100670533 DT.40248085 DT.65284236 24/27 AceView cDNA sequences (see all 27): BM459721 BQ961856 BF897445 BQ772226 BV176927 N71581 BF880147 BQ677416 BF880159 BX509771 AI301608 CA774630 AI768162 N99573 BF901238 BF897614 BF508759 BX509188 BE163241 BF901322 R85225 BI519909 BF894483 BQ230221
GeneLoc Exon Structure
|
Expression
for AP5B1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AP5B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCACTTGCC
About this image
See AP5B1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AP5B1
SOURCE GeneReport for Unigene cluster: Hs.591957
SABiosciences Custom PCR Arrays for AP5B1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP5B1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat AP5B1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP5B1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP5B1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP5B1 |
Orthologs
for AP5B1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for AP5B1 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for AP5B1 (if available)
TreeFam Gene Tree for AP5B1 (if available) |
Paralogs
for AP5B1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for AP5B1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AP5B1 (65543364 - 65548273 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AP5B1: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for AP5B1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AP5B1 for disorders About GeneDecksing
OMIM gene information: 614367
OMIM disorders: --
4  diseases for AP5B1: About MalaCardshereditary spastic paraplegia spastic paraplegia paraplegia spasticity
Export disorders for AP5B1 gene to outside databases
|
Publications
for AP5B1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AP5B1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with AP5B1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The fifth adaptor protein complex. (PubMed id 22022230)1, 2, 3 Hirst J.... Robinson M.S. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A genome-scale DNA repair RNAi screen identifies SPG4 8 as a novel gene associated with hereditary spastic paraplegia. (PubMed id 20613862)2 SA8abicki M....Buchholz F. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for AP5B1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AP5B1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AP5B1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AP5B1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for AP5B1 gene:
Search GeneIP for patents involving AP5B1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AP5B1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AP5B1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AP5B1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP5B1 | | | OriGene Protein Over-expression Lysate for AP5B1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for AP5B1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP5B1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP5B1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AP5B1 | | OriGene Custom Protein Services for AP5B1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AP5B1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP5B1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP5B1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP5B1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP5B1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP5B1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for AP5B1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP5B1 |
|  |  |  | | | | Search ThermoFisher Antibodies for AP5B1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP5B1 |
|
|
|
|
