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AP4M1 Gene

protein-coding   GIFtS: 52
GCID: GC07P099699

Adaptor-Related Protein Complex 4, Mu 1 Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adaptor-Related Protein Complex 4, Mu 1 Subunit1 2     SPG502 5
Mu Subunit Of AP-41 2 3     MU-42
AP-4 Adapter Complex Mu Subunit1 3     MU-ARP22
Adaptor-Related Protein Complex AP-4 Mu4 Subunit1 2     Adapter-Related Protein Complex 4 Mu-1 Subunit2
Mu-Adaptin-Related Protein-21 2     AP-4 Complex Subunit Mu-12
Adapter-Related Protein Complex 4 Subunit Mu-12 3     mu4-adaptin2
Mu-Adaptin-Related Protein 22 3     MUARP23
mu42 3     Mu4-adaptin3
CPSQ32 5     mu-ARP23

External Ids:    HGNC: 5741   Entrez Gene: 91792   Ensembl: ENSG000002218387   OMIM: 6022965   UniProtKB: O001893   

Export aliases for AP4M1 gene to outside databases

Previous GC identifers: GC07P098233 GC07P099296 GC07P099310 GC07P099343 GC07P099537 GC07P094334


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AP4M1 Gene:
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor
complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins
with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AP4M1 Gene:
AP4M1 (adaptor-related protein complex 4, mu 1 subunit) is a protein-coding gene. Diseases associated with AP4M1 include acute frontal sinusitis, and spastic paraplegia 50, autosomal recessive. GO annotations related to this gene include transporter activity. An important paralog of this gene is AP3M1.

UniProtKB/Swiss-Prot: AP4M1_HUMAN, O00189
Function: Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat
involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Plays a role
in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits
amyloidogenic processing of APP

Gene Wiki entry for AP4M1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AP4M1 gene promoter:
         Max1   C/EBPbeta   Elk-1   FOXF2   MyoD   Tal-1beta   E47   SEF-1 (1)   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAP4M1 promoter sequence
   Search Chromatin IP Primers for AP4M1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP4M1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

AP4M1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP4M1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P099699:  view genomic region     (about GC identifiers)

Start:
99,699,130 bp from pter      End:
99,707,968 bp from pter
Size:
8,839 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,059,249-99,064,921     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AP4M1_HUMAN, O00189 (See protein sequence)
Recommended Name: AP-4 complex subunit mu-1  
Size: 453 amino acids; 49977 Da
Subunit: Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit
AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type
AP4S1). Interacts with the C-terminal domain of GRID2 (By similarity). Interacts with tyrosine-based sorting
signals on the cytoplasmic tail of cargo proteins, such as LAMP2 and APP
1 PDB 3D structure from and Proteopedia for AP4M1:
3L81 (3D)    
Secondary accessions: D6W5U1 Q8WV65 Q9UHK9

Explore the universe of human proteins at neXtProt for AP4M1: NX_O00189

Explore proteomics data for AP4M1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18, Lys324
  • Modification sites at PhosphoSitePlus

  • See AP4M1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004713.2  
    ENSEMBL proteins: 
     ENSP00000377625   ENSP00000401613   ENSP00000400598   ENSP00000403663   ENSP00000352603  
     ENSP00000414286   ENSP00000396928   ENSP00000412185   ENSP00000406106   ENSP00000406676  
     ENSP00000391585   ENSP00000393723  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR018240 Clathrin_mu_CS
     IPR008968 Clathrin_mu_C
     IPR022775 AP_mu_sigma_su
     IPR011012 Longin-like_dom
     IPR028565 MHD

    Graphical View of Domain Structure for InterPro Entry O00189

    ProtoNet protein and cluster: O00189

    2 Blocks protein domains:
    IPB000804 Clathrin adaptor complex
    IPB001392 Clathrin adaptor complex


    UniProtKB/Swiss-Prot: AP4M1_HUMAN, O00189
    Similarity: Belongs to the adaptor complexes medium subunit family
    Similarity: Contains 1 MHD (mu homology) domain


    AP4M1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP4M1_HUMAN, O00189
    Function: Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat
    involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Plays a role
    in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits
    amyloidogenic processing of APP

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS10066790
    GO:0005515protein binding ----
         
    AP4M1 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-548t hsa-miR-493* hsa-let-7g* hsa-let-7a-2* hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidAP4M1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AP4M1_HUMAN, O00189: Golgi apparatus, trans-Golgi network. Membrane, coated pit. Note=Associated with the
    trans-Golgi network. Found in soma and dendritic shafts of neuronal cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    nucleus3
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000138Golgi trans cisterna TAS10066790
    GO:0005802trans-Golgi network IDA--
    GO:0005905coated pit IEA--
    GO:0030119AP-type membrane coat adaptor complex TAS10066790
    GO:0030131clathrin adaptor complex IEA--

    AP4M1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AP4M1 About    
    See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for AP4M1):
        Lysosome


    AP4M1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP4M1
    Interactions:

        GeneGlobe Interaction Network for AP4M1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AP4M1 (O001893 ENSP000003526034) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF1P840773, ENSP000002721024I2D: score=2 STRING: ENSP00000272102
    TGOLN2O434933, ENSP000003666034I2D: score=2 STRING: ENSP00000366603
    AP4B1Q9Y6B73, ENSP000002566584I2D: score=1 STRING: ENSP00000256658
    AP4E1Q9UPM83, ENSP000002618424I2D: score=1 STRING: ENSP00000261842
    CACNG3O603593, ENSP000000052844I2D: score=1 STRING: ENSP00000005284
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006886intracellular protein transport IMP--
    GO:0006895Golgi to endosome transport IMP--
    GO:0016192vesicle-mediated transport TAS10066790

    AP4M1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AP4M1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AP4M1 gene: 
    NM_004722.3  

    Unigene Cluster for AP4M1:

    Adaptor-related protein complex 4, mu 1 subunit
    Hs.632317  [show with all ESTs]
    Unigene Representative Sequence: NM_004722
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394061 ENST00000438383 ENST00000445208 ENST00000429084 ENST00000359593(uc011kjg.1 uc010lgl.1 uc003utb.4 uc011kjh.2)
    ENST00000439416 ENST00000478501 ENST00000446007 ENST00000421755(uc003utd.3)
    ENST00000463195 ENST00000416938(uc003ute.4) ENST00000422582(uc003utf.4)
    ENST00000495154 ENST00000479916 ENST00000450807 ENST00000445295 ENST00000489387

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate AP4M1:
    hsa-miR-548t hsa-miR-493* hsa-let-7g* hsa-let-7a-2* hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidAP4M1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AP4M1
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat AP4M1
      QuantiFast Probe-based Assays in human, mouse, rat AP4M1

    Additional mRNA sequence: 

    AF020796.1 AF155158.1 AK055686.1 AK293590.1 AK296651.1 AK304489.1 AK315782.1 BC012023.1 
    BC018705.1 Y08387.1 

    Selected DOTS entries (see all 26):

    DT.100767792  DT.450124  DT.100723809  DT.100723808  DT.100876224  DT.121080681  DT.121080714  DT.100723773 
    DT.91809193  DT.121080549  DT.65286948  DT.97802060  DT.100645712  DT.100723763  DT.40133352  DT.92468297 
    DT.121080685  DT.92044834  DT.100059865  DT.100059866  DT.121080631  DT.100044202  DT.100670392  DT.100723768 

    Selected AceView cDNA sequences (see all 133):

    BI823458 AL554598 AI313412 AW780243 BQ953049 CR625655 BU677515 CR590642 
    BC018705 AL701882 AI590538 CR611943 CR621800 CR625474 NM_004722 AL561446 
    BI766320 BQ944961 CR595500 BU554045 BM014189 BU734074 CB150140 AI674467 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AP4M1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCAATGCC
    AP4M1 Expression
    About this image

    AP4M1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AP4M1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632317

    UniProtKB/Swiss-Prot: AP4M1_HUMAN, O00189
    Tissue specificity: Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP4M1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap4m11 , 5 adaptor-related protein complex AP-4, mu 11, 5 86.71(n)1
    93.76(a)1
      5 (76.98 cM)5
    117811  NM_021392.41  NP_067367.31 
     1381720025 
    lizard
    (Anolis carolinensis)
    Reptilia AP4M16
    adaptor-related protein complex 4, mu 1 subunit
    63(a)
    1 ↔ 1
    GL343882.1(23451-34386)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ap4m11 adaptor-related protein complex 4, mu 1 subunit 63.8(n)
    62.44(a)
      100127610  NM_001112965.1  NP_001106436.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ap4m11 adaptor-related protein complex 4, mu 1 subunit 63.64(n)
    62.95(a)
      436945  NM_001002672.1  NP_001002672.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APM16
    Mu1-like medium subunit of the clathrin-associated...
    24(a)
    1 → many
    XVI(51244-52671) YPL259C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G245501 AT4G24550 46.53(n)
    36.61(a)
      828557  NM_118588.6  NP_194186.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06203001 Os07g0620300 48.89(n)
    37.76(a)
      4343931  NM_001066834.1  NP_001060299.1 


    ENSEMBL Gene Tree for AP4M1 (if available)
    TreeFam Gene Tree for AP4M1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AP4M1 gene
    AP3M12  AP1M22  AP3M22  AP2M12  AP1M12  
    4 SIMAP similar genes for AP4M1 using alignment to 11 protein entries:     AP4M1_HUMAN (see all proteins):
    DKFZp686E11263    AP2M1    AP1M2    AP1M1

    AP4M1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AP4M1 (see all 294)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020889241,2
    --94338366(+) GTCAGA/GGCTGA 2 E G mis10--------
    rs2012550151,2
    --94338376(+) AGAGGC/TGAGGA 1 -- spd10--------
    rs1458872631,2
    C,F--94338528(+) GCCAGG/CAATCC 2 /A /G mis12Minor allele frequency- C:0.00NA EU 5871
    rs1442530831,2
    C--94338565(+) TCTGTG/AAATCT 2 /V syn11Minor allele frequency- A:0.00NA 4550
    rs412809681,2
    C,F--94338600(+) CCTCCG/ACTTGC 2 /H /R mis16Minor allele frequency- A:0.07NA EU 5999
    rs1178203381,2
    C,F--94338666(+) GGGGAA/CGGGGG 1 -- int11Minor allele frequency- C:0.06EA 120
    rs2009007931,2
    C--94338681(+) GGGGTC/TGTGAG 1 -- int10--------
    rs1423258841,2
    C,F--94338747(+) CTCTCC/TGATGA 2 S syn11Minor allele frequency- T:0.00NA 4552
    rs1922709331,2
    --94338765(+) TCACCA/GCTCCC 2 P syn10--------
    rs2015800041,2
    --94338766(+) CACCGC/TTCCCC 2 L F mis10--------

    HapMap Linkage Disequilibrium report for AP4M1 (99699130 - 99707968 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AP4M1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv469687CNV Loss16826518

    Human Gene Mutation Database (HGMD): AP4M1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AP4M1
    DNA2.0 Custom Variant and Variant Library Synthesis for AP4M1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602296   
    OMIM disorders: 612936  
    UniProtKB/Swiss-Prot: AP4M1_HUMAN, O00189
  • Cerebral palsy, spastic quadriplegic 3 (CPSQ3) [MIM:612936]: A non-progressive disorder of movement
    and/or posture resulting from defects in the developing central nervous system. Affected individuals present
    postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent
    walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized
    hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent
    or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the
    clinical picture. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20 diseases for AP4M1:    
    About MalaCards
    acute frontal sinusitis    spastic paraplegia 50, autosomal recessive    frontal sinusitis    hypertonia
    infantile hypotonia    cerebral palsy    sinusitis    hypotonia
    strabismus    quadriplegia    intellectual disability    paraplegia
    short stature    cerebritis    spasticity    mental retardation
    multiple myeloma    myeloma    alzheimer's disease    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for AP4M1:
    Cerebral palsy     Quadriplegia

    AP4M1 for disorders           About GeneDecksing


    Export disorders for AP4M1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AP4M1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with AP4M1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2. (PubMed id 9013859)1, 2, 3, 9 Wang X. and Kilimann M.W. (FEBS Lett. 1997)
    2. Adaptor protein complex 4 deficiency causes severe autosomal- recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature. (PubMed id 21620353)1, 3 Abou Jamra R.... Colleaux L. (Am. J. Hum. Genet. 2011)
    3. Mutation in the AP4M1 gene provides a model for neuroaxonal injury in cerebral palsy. (PubMed id 19559397)1, 2 Verkerk A.J.... Mancini G.M. (Am. J. Hum. Genet. 2009)
    4. Signal-binding specificity of the mu4 subunit of the adaptor protein complex, AP-4. (PubMed id 11139587)1, 2 Aguilar R.C.... Bonifacino J.S. (J. Biol. Chem. 2001)
    5. AP-4, a novel protein complex related to clathrin adaptors. (PubMed id 10066790)1, 3 Dell'Angelica E.C.... Bonifacino J.S. (J. Biol. Chem. 1999)
    6. Characterization of a fourth adaptor-related protein complex. (PubMed id 10436028)1, 2 Hirst J.... Robinson M.S. (Mol. Biol. Cell 1999)
    7. AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells. (PubMed id 11802162)1, 9 Simmen T....Hunziker W. (Nat. Cell Biol. 2002)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9179 HGNC: 574 AceView: AP4M1 Ensembl:ENSG00000221838 euGenes: HUgn9179
    ECgene: AP4M1 Kegg: 9179 H-InvDB: AP4M1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AP4M1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AP4M1 gene:
    Search GeneIP for patents involving AP4M1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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