AP4B1 Gene
protein-coding GIFtS: 54
GCID: GC01M114437
|
|
adaptor-related protein complex 4, beta 1 subunit(Previous name: spastic paraplegia 47 )
(Previous symbol: SPG47)
| |
Aliases
for AP4B1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adaptor-Related Protein Complex 4, Beta 1 Subunit1 2 | | Beta 4 Subunit Of AP-42 | | BETA-41 2 | | Beta4-Adaptin1 | | SPG471 2 | | Beta4-Adaptin1 | | Spastic Paraplegia 471 2 | | Adapter-Related Protein Complex 4 Subunit Beta-13 | | CPSQ52 | | AP-4 Adapter Complex Subunit Beta3 | | AP-4 Complex Subunit Beta-12 | | Beta Subunit Of AP-43 |
Export aliases for AP4B1 gene to outside databasesPrevious GC identifers: GC01M114851 GC01M113319 GC01M113537 GC01M113736 GC01M114149 GC01M114239 GC01M112295 |
Summaries
for AP4B1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for AP4B1:
This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins fromthe trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsyspastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoformshave been found for this gene. (provided by RefSeq, Dec 2011)
UniProtKB/Swiss-Prot: AP4B1_HUMAN, Q9Y6B7Function: Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteinsfrom the trans-Golgi network (TGN) to the endosomal-lysosomal system
Gene Wiki entry for AP4B1
|
Genomic Views
for AP4B1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AP4B1 gene promoter:
Bach2 Lmo2 Nkx2-5 Max HEN1 PPAR-gamma1 Zic1 HFH-1 PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for AP4B1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP4B1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.2AP4B1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M114437: view genomic region
(about GC identifiers)
Start:
|
114,437,370 bp from pter |
End:
|
114,447,823 bp from pter |
Size:
|
10,454 bases |
Orientation:
|
minus strand |
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Proteins
for AP4B1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AP4B1_HUMAN, Q9Y6B7 (See
protein sequence)Recommended Name: AP-4 complex subunit beta-1 Size: 739 amino acids; 83260 Da
Subunit: Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).Interacts with ENTHD2; this interaction requires the presence of a functional AP-4 complex
Subcellular location: Golgi apparatus, trans-Golgi network. Note=Associated with the trans-Golgi network. Found in somaand dendritic shafts of neuronal cells
Sequence caution: Sequence=BAD93054.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q59EJ4 Q96CL6Explore the universe of human proteins at neXtProt for AP4B1: NX_Q9Y6B7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6B7
AP4B1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001240781.1 NP_001240782.1 NP_006585.2
ENSEMBL proteins: ENSP00000358580 ENSP00000358582 ENSP00000256658 ENSP00000358577 ENSP00000393622 ENSP00000358584 ENSP00000358579 Reactome Protein details: Q9Y6B7
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
AP4B1 for ontologies About GeneDecksing
AP4B1 Antibody Products:
Assay Products for AP4B1: |
Protein
Domains /
Families
for AP4B1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AP4B1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9Y6B7ProtoNet protein and cluster: Q9Y6B7 1 Blocks protein family: IPB002553 Adaptin
UniProtKB/Swiss-Prot: AP4B1_HUMAN, Q9Y6B7Similarity: Belongs to the adaptor complexes large subunit family |
Function
for AP4B1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AP4B1_HUMAN, Q9Y6B7Function: Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteinsfrom the trans-Golgi network (TGN) to the endosomal-lysosomal system
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP4B1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP4B1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AP4B1 (NM_006594) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP4B1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP4B1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP4B1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
AP4B1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for AP4B1:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ap4b1):
AP4B1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AP4B1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin derived vesicle budding | | | 2 | Membrane Trafficking | | | 3 | Lysosome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for AP4B1
1 
Kegg Pathway (Kegg details for AP4B1):
AP4B1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AP4B1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/47 Interacting proteins for AP4B1 (Q9Y6B73 ENSP000002566584) via UniProtKB, MINT, STRING, and/or I2D (see all 47)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
-- | -- | | GO:0006886 | intracellular protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
IEA | -- |
AP4B1 for ontologies About GeneDecksing
|
Drugs & Compounds
for AP4B1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AP4B1
Search CenterWatch for drugs/clinical trials and news about AP4B1
|
Transcripts
for AP4B1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AP4B1 gene (3 alternative transcripts): NM_001253852.1 NM_001253853.1 NM_006594.3 Unigene Cluster for AP4B1: Adaptor-related protein complex 4, beta 1 subunit Hs.515048 [show with all ESTs]Unigene Representative Sequence: NM_00659415 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369567 ENST00000369569(uc001eeb.3 uc001eec.3) ENST00000256658(uc010owp.2 uc001eed.3)
ENST00000479285(uc001eea.1) ENST00000462591(uc001eee.1) ENST00000479801
ENST00000484201 ENST00000460653 ENST00000369564 ENST00000489499 ENST00000432415
ENST00000489092 ENST00000369571 ENST00000472122 ENST00000369566(uc010owq.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP4B1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP4B1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AP4B1 (NM_006594) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AP4B1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP4B1 |
Additional cDNA sequence: AB209817.1 AF092094.1 AK001045.1 AK057567.1 AK093740.1 AK298037.1 AK300204.1 AK314641.1 BC014146.2 21 DOTS entries: DT.100682194 DT.100685471 DT.100774945 DT.95300298 DT.215048 DT.100726542 DT.95099109 DT.97789515 DT.100689732 DT.95099111 DT.97802595 DT.100740237 DT.121428297 DT.302629 DT.95250757 DT.101958523 DT.40205034 DT.100664421 DT.100689730 DT.40293773 DT.95321586 24/167 AceView cDNA sequences (see all 167): BU681067 BM905253 BG533935 BQ717612 AI990383 Z45954 Z41571 BM835760 BM151133 AA968423 CA307639 AA383415 AI270746 BM830610 BQ574363 BM718497 CA952744 BU626203 AW466875 BM773419 BX439419 AL520924 AI803233 BM313638
GeneLoc Exon Structure
5/20 Alternative Splicing Database (ASD) splice patterns (SP) for AP4B1 (see all 20) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
|---|
|
| SP1: | - | | | | | | - | | | | - | | | | - | | | | | | | | | | |
| SP2: | - | | | | | | - | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for AP4B1
|
Expression
for AP4B1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AP4B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAGCATAC
About this image
See AP4B1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AP4B1
SOURCE GeneReport for Unigene cluster: Hs.515048
UniProtKB/Swiss-Prot: AP4B1_HUMAN, Q9Y6B7Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for AP4B1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP4B1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP4B1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP4B1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP4B1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP4B1 |
Orthologs
for AP4B1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for AP4B1 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
AP4B11 |
adaptor-related protein complex 4, beta 1 subunit |
69.79(n)
74.48(a) |
|
419879 NM_001030917.1 NP_001026088.1 |
lizard
(Anolis carolinensis) |
Reptilia |
AP4B16 |
-- |
77(a) |
1 ↔ 1 |
4(129604682-129617408) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc638782 |
hypothetical protein MGC63878 |
74.3(n) |
|
393309 BC053128.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G114901 |
beta-adaptin-like protein A |
47.77(n)
37.04(a) |
|
831021 NM_001203361.1 NP_001190290.1 |
rice
(Oryza sativa) |
Liliopsida |
-- |
adaptin, putative, expressed |
26(a) |
1 ↔ 1 |
1(24993688-25001811) |
ENSEMBL Gene Tree for AP4B1 (if available)
TreeFam Gene Tree for AP4B1 (if available) |
Paralogs
for AP4B1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AP4B1 gene
- AP2B12 AP1B12
3 SIMAP similar genes for AP4B1 using alignment to 6 protein entries: AP4B1_HUMAN (see all proteins):DKFZp781K0743 AP1B1 AP2B1
AP4B1 for paralogs About GeneDecksing
|
Genomic Variants
for AP4B1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AP4B1 (114437370 - 114447823 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for AP4B1
4 CNVs: 58325 2322 3306 64644
Human Gene Mutation Database (HGMD): AP4B1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP4B1 |
|
Disorders
/ Diseases
for AP4B1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AP4B1 for disorders About GeneDecksing
OMIM gene information: 607245
OMIM disorders: --
UniProtKB/Swiss-Prot: AP4B1_HUMAN, Q9Y6B7
Defects in AP4B1 are the cause of cerebral palsy spastic quadriplegic type 5 (CPSQ5) [MIM:614066]. CPSQ5 is aneurodevelopmental disorder characterized by neonatal hypotonia that progresses to hypertonia and spasticity, andsevere mental retardation with poor or absent speech development
11  diseases for AP4B1: About MalaCardsspasticity cerebral palsy spastic paraplegia paraplegia
cerebritis short stature hypertonia intellectual disability
hypotonia malaria neuronitis
1 disease from the University of Copenhagen DISEASES database for AP4B1:Paraplegia Human Genome Epidemiology (HuGE) Navigator: AP4B1 (1 document)
Export disorders for AP4B1 gene to outside databases
|
Publications
for AP4B1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AP4B1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with AP4B1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- AP-4, a novel protein complex related to clathrin adaptors. (PubMed id 10066790)1, 2, 3 Dell'Angelica E.C.... Bonifacino J.S. (1999)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Mutation in the AP4B1 gene cause hereditary spastic pa raplegia type 47 (SPG47) . (PubMed id 22290197)1 Bauer P....Schols L. (2012)
- Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. (PubMed id 22472443)2 Borner G.H.... Robinson M.S. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Adaptor protein complex 4 deficiency causes severe autosomal- recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature. (PubMed id 21620353)2 Abou Jamra R.... Colleaux L. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
|
External Searches for AP4B1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AP4B1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AP4B1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AP4B1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AP4B1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AP4B1 gene:
Search GeneIP for patents involving AP4B1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for AP4B1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AP4B1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AP4B1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AP4B1 | | | OriGene Protein Over-expression Lysate for AP4B1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AP4B1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AP4B1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AP4B1 | | OriGene Custom Protein Services for AP4B1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AP4B1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AP4B1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP4B1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP4B1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP4B1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP4B1 |
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| | | | Search Tocris compounds for AP4B1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP4B1 |
|  |  |  | | | | Search ThermoFisher Antibodies for AP4B1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP4B1 |
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