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AP3S2 Gene

protein-coding   GIFtS: 57
GCID: GC15M090373

Adaptor-Related Protein Complex 3, Sigma 2 Subunit

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adaptor-Related Protein Complex 3, Sigma 2 Subunit1 2     AP-3 Complex Subunit Sigma-22
Adapter-Related Protein Complex 3 Subunit Sigma-22 3     Clathrin-Associated/Assembly/Adaptor Protein, Small 4, 22-KD2
Sigma-Adaptin 3b2 3     sigma-3B-adaptin2
AP-3 Complex Subunit Sigma-3B2 3     sigma3b2
AP3S32     Sigma-3B-adaptin3
Adaptor Complex Sigma3B2     Sigma3B-adaptin3

External Ids:    HGNC: 5711   Entrez Gene: 102392   Ensembl: ENSG000001578237   OMIM: 6024165   UniProtKB: P597803   

Export aliases for AP3S2 gene to outside databases

Previous GC identifers: GC15M086781 GC15M083742 GC15M087964 GC15M088106 GC15M088177 GC15M066486


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AP3S2 Gene:
AP3S2 (adaptor-related protein complex 3, sigma 2 subunit) is a protein-coding gene. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is AP3S1.

UniProtKB/Swiss-Prot: AP3S2_HUMAN, P59780
Function: Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is
associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles
from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1
complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and
nerve terminals

Gene Wiki entry for AP3S2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the AP3S2 gene promoter:
         STAT1   AP-1   POU3F1   MZF-1   HEN1   PPAR-gamma1   POU2F1   FOXO4   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAP3S2 promoter sequence
   Search Chromatin IP Primers for AP3S2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AP3S2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

AP3S2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP3S2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M090373:  view genomic region     (about GC identifiers)

Start:
90,373,831 bp from pter      End:
90,437,617 bp from pter
Size:
63,787 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AP3S2_HUMAN, P59780 (See protein sequence)
Recommended Name: AP-3 complex subunit sigma-2  
Size: 193 amino acids; 22017 Da
Subunit: Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit
AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small
adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By
similarity)
Secondary accessions: B2R677 B4DGQ3 O09077 O09149 Q53H83 Q99589
Alternative splicing: 3 isoforms:  P59780-1   Q7Z6K5-2   P59780-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for AP3S2: NX_P59780

Explore proteomics data for AP3S2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys166
  • Modification sites at PhosphoSitePlus

  • See AP3S2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005820.1  
    ENSEMBL proteins: 
     ENSP00000338777   ENSP00000394170   ENSP00000453223   ENSP00000453852   ENSP00000452862  
     ENSP00000454027   ENSP00000453380   ENSP00000453288  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000804 Clathrin_sm-chain_CS
     IPR022775 AP_mu_sigma_su
     IPR016635 AP_complex_ssu
     IPR011012 Longin-like_dom

    Graphical View of Domain Structure for InterPro Entry P59780

    ProtoNet protein and cluster: P59780

    1 Blocks protein domain: IPB000804 Clathrin adaptor complex

    UniProtKB/Swiss-Prot: AP3S2_HUMAN, P59780
    Similarity: Belongs to the adaptor complexes small subunit family


    Find genes that share domains with AP3S2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP3S2_HUMAN, P59780
    Function: Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is
    associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles
    from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1
    complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and
    nerve terminals

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008565protein transporter activity IEA--
         
    Find genes that share ontologies with AP3S2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AP3S2:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Ap3s2 (no phenotypes)

    Find genes that share phenotypes with AP3S2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AP3S2
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    miRNA
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    miRTarBase miRNAs that target AP3S2:
    hsa-mir-18a-5p (MIRT031346), hsa-mir-19b-3p (MIRT031161), hsa-mir-20a-5p (MIRT050499)

    Block miRNA regulation of human, mouse, rat AP3S2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AP3S2 (see all 20):
    hsa-miR-3128 hsa-miR-938 hsa-miR-4263 hsa-miR-4314 hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3119 hsa-miR-30c-2*
    SwitchGear 3'UTR luciferase reporter plasmidAP3S2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AP3S2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP3S2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AP3S2_HUMAN, P59780: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side
    (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the
    Golgi complex (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0016020membrane ----
    GO:0030117membrane coat ----
    GO:0030123AP-3 adaptor complex IDA9118953
    GO:0030659cytoplasmic vesicle membrane IEA--

    Find genes that share ontologies with AP3S2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AP3S2 About    
    See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome


    Find genes that share SuperPaths with AP3S2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for AP3S2):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AP3S2
    Interactions:

        Search GeneGlobe Interaction Network for AP3S2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for AP3S2 (P597803 ENSP000003387774) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP3D1O146173, ENSP000003440554I2D: score=4 STRING: ENSP00000344055
    AP3B1O002033, ENSP000002551944I2D: score=3 STRING: ENSP00000255194
    AP3S1Q925723, ENSP000003253694I2D: score=2 STRING: ENSP00000325369
    ARF1P840773, ENSP000002721024I2D: score=1 STRING: ENSP00000272102
    AP3M1Q9Y2T23, ENSP000003474084I2D: score=1 STRING: ENSP00000347408
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006886intracellular protein transport IEA--
    GO:0008089anterograde axon cargo transport ISS--
    GO:0015031protein transport ----
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with AP3S2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AP3S2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AP3S2 gene: 
    NM_005829.4  

    Unigene Cluster for AP3S2:

    Adaptor-related protein complex 3, sigma 2 subunit
    Hs.632161  [show with all ESTs]
    Unigene Representative Sequence: NR_023361
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336418(uc010bns.3 uc002bor.4 uc002boq.4 uc002bos.4)
    ENST00000423566 ENST00000558926 ENST00000558011 ENST00000560940 ENST00000560771
    ENST00000557999 ENST00000558806 ENST00000561410 ENST00000559162 ENST00000558999
    ENST00000558186 ENST00000560184 ENST00000560251 ENST00000559601
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate AP3S2 (see all 20):
    hsa-miR-3128 hsa-miR-938 hsa-miR-4263 hsa-miR-4314 hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3119 hsa-miR-30c-2*
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      QuantiTect SYBR Green Assays in human, mouse, rat AP3S2
      QuantiFast Probe-based Assays in human, mouse, rat AP3S2

    Additional mRNA sequence: 

    AK222698.1 AK312467.1 AL109702.1 AL110108.1 BC002785.2 BC007773.2 BC010020.2 BC010615.2 
    BC063707.1 NR_023361.1 NR_037582.1 X99459.1 

    20 DOTS entries:

    DT.314588  DT.101984660  DT.114484  DT.97802609  DT.99981195  DT.100801881  DT.100801887  DT.101957058 
    DT.100028814  DT.121061681  DT.92471397  DT.121061815  DT.121061838  DT.40257521  DT.97839320  DT.100658091 
    DT.121061794  DT.441702  DT.92024276  DT.95195896 

    Selected AceView cDNA sequences (see all 436):

    Z41847 CA446892 CA393628 BQ068166 BM790064 CD742691 AA371387 AK093274 
    BG820878 AI522099 BE221356 BU171539 X99459 BM544767 AW303655 BM853935 
    CR597548 AI760622 AL035815 AX748027 AK000495 AL542015 BQ954583 AI677927 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for AP3S2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e · 13f
    SP1:                                      -           -     -     -     -     -     -                                             
    SP2:                                -                 -     -     -     -     -     -                                             
    SP3:                                -     -           -     -     -     -     -     -                                             
    SP4:                                -     -           -     -     -     -     -     -                                             
    SP5:                                -     -                                                                                       


    ECgene alternative splicing isoforms for AP3S2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AP3S2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGTTCAATA
    AP3S2 Expression
    About this image

    AP3S2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AP3S2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632161

    UniProtKB/Swiss-Prot: AP3S2_HUMAN, P59780
    Tissue specificity: Present in all adult tissues examined

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP3S2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP3S2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap3s21 , 5 adaptor-related protein complex 3, sigma 2 subunit1, 5 91.02(n)1
    100(a)1
      7 (45.23 cM)5
    117781  NM_009682.31  NP_033812.31 
     798753325 
    chicken
    (Gallus gallus)
    Aves AP3S26
    adaptor-related protein complex 3, sigma 2 subunit...
    70(a)
    1 ↔ 1
    10(19497720-19501385)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.42892 Xenopus laevis transcribed sequence with moderate similarity more 78.97(n)    BX849614.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.183252 Transcribed sequence with strong similarity to protein more 78.45(n)    BQ132123.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta or1 , 3 ommochrome biosynthesis3
    orange1
    78(a)3
    70.15(n)1
    78.57(a)1
      60A143
    439431  NM_080532.31  NP_536793.11 
    worm
    (Caenorhabditis elegans)
    Secernentea aps-31 aps-3 66.49(n)
    75.27(a)
      171691  NM_170798.3  NP_740780.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APS36
    Small subunit of the clathrin-associated adaptor c...
    36(a)
    1 → many
    X(395931-396592) YJL024C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G508601 AT3G50860 55.69(n)
    50(a)
      824250  NM_114946.2  NP_190655.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g02284001 Os03g0228400 52.87(n)
    50.96(a)
      4332139  NM_001055986.1  NP_001049451.1 


    ENSEMBL Gene Tree for AP3S2 (if available)
    TreeFam Gene Tree for AP3S2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AP3S2 gene
    AP3S12  
    8 SIMAP similar genes for AP3S2 using alignment to 7 protein entries:     AP3S2_HUMAN (see all proteins):
    C15orf38-AP3S2    AP3S1    AP2S1    AP4S1    DKFZp779P0659    AP1S1
    AP1S2    AP1S3

    Find genes that share paralogs with AP3S2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AP3S2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1678655CNV Deletion17803354
    esv2667255CNV Deletion23128226
    esv2750010CNV Deletion23290073
    nsv1661CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602416    OMIM disorders: --


    Find genes that share disorders with AP3S2           About GenesLikeMe

    Genetic Association Database (GAD): AP3S2
    Human Genome Epidemiology (HuGE) Navigator: AP3S2 (2 documents)

    Export disorders for AP3S2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AP3S2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with AP3S2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. AP-3: an adaptor-like protein complex with ubiquitous expression. (PubMed id 9118953)1, 2, 3 Dell'Angelica E.C....Bonifacino J.S. (EMBO J. 1997)
    2. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PubMed id 21874001)1, 4 Kooner J.S....Chambers J.C. (Nat. Genet. 2011)
    3. Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics. (PubMed id 20966410)1, 4 Dong C....Sacco R.L. ( a journal of cerebral circulation 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genome-wide association study identifies three novel loci for type 2 diabetes. (PubMed id 23945395)1 Hara K....Kadowaki T. (Hum. Mol. Genet. 2014)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10239 HGNC: 571 AceView: AP3S2andMGC61550 Ensembl:ENSG00000157823 euGenes: HUgn10239
    ECgene: AP3S2 Kegg: 10239 H-InvDB: AP3S2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AP3S2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AP3S2 gene:
    Search GeneIP for patents involving AP3S2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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