Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AP3M2 Gene

protein-coding   GIFtS: 55
GCID: GC08P042027

Adaptor-Related Protein Complex 3, Mu 2 Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adaptor-Related Protein Complex 3, Mu 2 Subunit1 2     AP47B2
Adapter-Related Protein Complex 3 Mu-2 Subunit2 3     CLA202
Clathrin Assembly Protein Assembly Protein Complex 1 Medium Chain Homolog
22 3
     AP-3 Complex Subunit Mu-22
Clathrin Coat Assembly Protein AP47 Homolog 22 3     Clathrin-Associated Protein AP47 Homolog 22
Clathrin Coat-Associated Protein AP47 Homolog 22 3     HA1 47kDA Subunit Homolog 22
Golgi Adaptor AP-1 47 KDa Protein Homolog 22 3     mu3B-adaptin2
P47B2 3     Mu3B-adaptin3
HA1 47 KDa Subunit Homolog 22 3     

External Ids:    HGNC: 5701   Entrez Gene: 109472   Ensembl: ENSG000000707187   OMIM: 6104695   UniProtKB: P536773   

Export aliases for AP3M2 gene to outside databases

Previous GC identifers: GC08P041394 GC08P042039 GC08P041751 GC08P042129 GC08P040537


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AP3M2 Gene:
This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the
adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and
specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified.
(provided by RefSeq, Aug 2008)

GeneCards Summary for AP3M2 Gene: 
AP3M2 (adaptor-related protein complex 3, mu 2 subunit) is a protein-coding gene. Diseases associated with AP3M2 include hermansky-pudlak syndrome, and endocarditis. An important paralog of this gene is AP3M1.

UniProtKB/Swiss-Prot: AP3M2_HUMAN, P53677
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is
associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles
from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1
complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and
nerve terminals




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AP3M2 gene promoter:
         MIF-1   LCR-F1   YY1   E47   c-Ets-1   S8   SRY   PPAR-gamma1   Nkx6-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAP3M2 promoter sequence
   Search SABiosciences Chromatin IP Primers for AP3M2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP3M2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.2

AP3M2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AP3M2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P042027:  view genomic region     (about GC identifiers)

Start:
42,010,464 bp from pter      End:
42,029,191 bp from pter
Size:
18,728 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AP3M2_HUMAN, P53677 (See protein sequence)
Recommended Name: AP-3 complex subunit mu-2  
Size: 418 amino acids; 46977 Da
Subunit: AP-3 associates with the BLOC-1 complex (By similarity). Adaptor protein complex 3 (AP-3) is a
heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a
medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2)
Subcellular location: Golgi apparatus
Secondary accessions: B2RCR0 D3DSY2

Explore the universe of human proteins at neXtProt for AP3M2: NX_P53677

Explore proteomics data for AP3M2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53677

  • AP3M2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AP3M2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001127768.1  NP_006794.1  

    ENSEMBL proteins: 
     ENSP00000428787   ENSP00000430200   ENSP00000380132   ENSP00000430616   ENSP00000431918  
     ENSP00000429515   ENSP00000430538   ENSP00000429435   ENSP00000429037   ENSP00000428279  
     ENSP00000429804   ENSP00000174653  

    Human Recombinant Protein Products for AP3M2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AP3M2
    GenScript Custom Purified and Recombinant Proteins Services for AP3M2
    Novus Biologicals AP3M2 Protein
    Novus Biologicals AP3M2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0030119AP-type membrane coat adaptor complex TAS8076832
    GO:0030131clathrin adaptor complex IEA--

    AP3M2 for ontologies           About GeneDecksing



    AP3M2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AP3M2
    GenScript Custom Superior Antibodies Services for AP3M2
    Novus Biologicals AP3M2 Antibodies
    Abcam antibodies for AP3M2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for AP3M2
    LSBio Antibodies in human, mouse, rat for AP3M2 

    Assay Products for AP3M2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AP3M2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AP3M2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR018240 Clathrin_mu_CS
     IPR001392 Clathrin_mu
     IPR008968 Clathrin_mu_C
     IPR022775 AP_mu_sigma_su
     IPR011012 Longin-like_dom

    Graphical View of Domain Structure for InterPro Entry P53677

    ProtoNet protein and cluster: P53677

    2 Blocks protein domains:
    IPB000804 Clathrin adaptor complex
    IPB001392 Clathrin adaptor complex


    UniProtKB/Swiss-Prot: AP3M2_HUMAN, P53677
    Similarity: Belongs to the adaptor complexes medium subunit family
    Similarity: Contains 1 MHD (mu homology) domain


    AP3M2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AP3M2_HUMAN, P53677
    Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is
    associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles
    from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1
    complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and
    nerve terminals

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    AP3M2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ap3m2):
     behavior/neurological  nervous system 

    AP3M2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ap3m2tm1Ohno for AP3M2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AP3M2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AP3M2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AP3M2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AP3M2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target AP3M2:
    hsa-mir-122 (MIRT003104)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AP3M2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate AP3M2 (see all 16):
    hsa-miR-623 hsa-miR-548p hsa-miR-7-2* hsa-miR-146a hsa-miR-545 hsa-miR-1205 hsa-miR-192 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidAP3M2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AP3M2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP3M2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AP3M2
    Sirion Biotech Customized adenovirus for overexpression of AP3M2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AP3M2 (see all 9)
    OriGene ORF clones in mouse, rat for AP3M2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AP3M2 (NM_006803)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP3M2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP3M2
    Sirion Biotech Customized lentivirus for stable overexpression of AP3M2 
                         Customized lentivirus expression plasmids for stable overexpression of AP3M2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AP3M2
    Search LifeMap BioReagents cell lines for AP3M2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP3M2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AP3M2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for AP3M2):
        Lysosome


    AP3M2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AP3M2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for AP3M2 (P536773 ENSP000001746534) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463I2D: score=1 
    AFTPHENSP000002388554STRING: ENSP00000238855
    AP1G1ENSP000003771484STRING: ENSP00000377148
    AP1G2ENSP000003124424STRING: ENSP00000312442
    AP1S1ENSP000003366664STRING: ENSP00000336666
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006886intracellular protein transport IEA--
    GO:0008089anterograde axon cargo transport ISS--
    GO:0016192vesicle-mediated transport ----
    GO:0048490anterograde synaptic vesicle transport ISS--

    AP3M2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AP3M2

    Search CenterWatch for drugs/clinical trials and news about AP3M2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AP3M2 gene (2 alternative transcripts): 
    NM_001134296.1  NM_006803.3  

    Unigene Cluster for AP3M2:

    Adaptor-related protein complex 3, mu 2 subunit
    Hs.654529  [show with all ESTs]
    Unigene Representative Sequence: NM_001134296
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518421(uc003xop.3) ENST00000517865(uc003xoq.2) ENST00000396926
    ENST00000520685 ENST00000521280 ENST00000530375 ENST00000522288 ENST00000521235
    ENST00000517969 ENST00000517922 ENST00000523249 ENST00000517499 ENST00000521899
    ENST00000522320 ENST00000522606 ENST00000520689 ENST00000174653(uc003xoo.3 uc010lxe.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AP3M2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate AP3M2 (see all 16):
    hsa-miR-623 hsa-miR-548p hsa-miR-7-2* hsa-miR-146a hsa-miR-545 hsa-miR-1205 hsa-miR-192 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidAP3M2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AP3M2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP3M2
    Clone
    Products:
         
    OriGene clones in human, mouse for AP3M2 (see all 9)
    OriGene ORF clones in mouse, rat for AP3M2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): AP3M2 (NM_006803)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AP3M2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP3M2
    Sirion Biotech Customized lentivirus for stable overexpression of AP3M2 
                         Customized lentivirus expression plasmids for stable overexpression of AP3M2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AP3M2
    OriGene qSTAR qPCR primer pairs in human, mouse for AP3M2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP3M2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP3M2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP3M2

    Additional mRNA sequence: 

    AK315228.1 BC021966.2 BC056257.1 BC056398.1 BX648354.1 BX648390.1 D38293.1 

    14 DOTS entries:

    DT.100723186  DT.416984  DT.75105633  DT.95169003  DT.120635675  DT.91673615  DT.91748851  DT.100669543 
    DT.40250523  DT.416986  DT.91723391  DT.100783099  DT.120635677  DT.100783097 

    24/213 AceView cDNA sequences (see all 213):

    AA310729 BM468708 CR608528 AL705978 BX648354 AA705505 BC021966 BQ425388 
    CR610500 BF115072 BX475052 AA587043 D38713 BC056398 AW583345 AU132048 
    AW132094 R68340 CA310340 BU159592 BQ942738 AA331409 BQ004292 AW583397 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for AP3M2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:              -     -                       -                       -                       -     -                                             
    SP2:              -     -     -                 -                       -                       -     -                                             
    SP3:              -     -     -     -     -     -                       -                       -     -                                             
    SP4:                                            -                       -                       -     -     -     -                                 
    SP5:                                                                                            -     -                                             


    ECgene alternative splicing isoforms for AP3M2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AP3M2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGAAGTA
    AP3M2 Expression
    About this image


    See AP3M2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AP3M2

    SOURCE GeneReport for Unigene cluster: Hs.654529
        SABiosciences Custom PCR Arrays for AP3M2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AP3M2
    OriGene qSTAR qPCR primer pairs in human, mouse for AP3M2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AP3M2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP3M2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP3M2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP3M2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AP3M2 gene from 10/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ap3m21 , 5 adaptor-related protein complex 3, mu 2 subunit1, 5 88.6(n)1
    98.33(a)1
      8 (11.42 cM)5
    649331  NM_029505.31  NP_083781.21 
     227873545 
    chicken
    (Gallus gallus)
    Aves AP3M21 adaptor-related protein complex 3, mu 2 subunit 83.81(n)
    96.65(a)
      426790  XM_424403.3  XP_424403.2 
    lizard
    (Anolis carolinensis)
    Reptilia AP3M26
    Uncharacterized protein
    98(a)
    1 ↔ 1
    GL343545.1(287680-295503)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.324232 Xenopus laevis transcribed sequence with strong similarity more 80.85(n)    BX846221.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ap3m21 adaptor-related protein complex 3, mu 2 subunit 77.11(n)
    91.15(a)
      415244  NM_001002154.1  NP_001002154.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cm1 , 3 ommochrome biosynthesis3
    carmine1
    69(a)3
    65.22(n)1
    70.29(a)1
      1 6E43
    316471  NM_176700.21  NP_788873.11 
    worm
    (Caenorhabditis elegans)
    Secernentea apm-36
    Protein APM-3
    63(a)
    1 → many
    X(954935-957763)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APM3(YBR288C)4 Mu3-like subunit of the clathrin associated protein more   --   2(779463-778012) 852591  NP_009847.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ZIP41 clathrin adaptor complexes medium subunit-like protein 50.16(n)
    44.66(a)
      842113  NM_104536.4  NP_176052.3 
    rice
    (Oryza sativa)
    Liliopsida Os05g03831001 hypothetical protein 50.28(n)
    43.1(a)
      4338648  NM_001061945.1  NP_001055410.1 


    ENSEMBL Gene Tree for AP3M2 (if available)
    TreeFam Gene Tree for AP3M2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AP3M2 gene
    AP3M12  AP4M12  AP1M22  AP2M12  AP1M12  
    5 SIMAP similar genes for AP3M2 using alignment to 9 protein entries:     AP3M2_HUMAN (see all proteins):
    AP3M1    DKFZp586G1518    AP1M1    AP1M2    AP2M1

    AP3M2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for AP3M2
    PGOHUM00000236203


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/466 SNPs in AP3M2 are shown (see all 466)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs117838641,2
    C,A,H--42008489(+) gcctcT/Ctgggt 2 -- us2k12Minor allele frequency- C:0.25NA CSA 4
    rs1811879921,2
    --42008510(+) CTCCCA/GTCTCA 2 -- us2k10--------
    rs1861677131,2
    --42008548(+) ACGTGA/CCATCA 2 -- us2k10--------
    rs1888736541,2
    --42008596(+) TTCATC/GATGTT 2 -- us2k10--------
    rs1462448231,2
    --42008618(+) TCTTGA/CACTCC 2 -- us2k10--------
    rs1506146021,2
    C--42008695(+) CCCAG-/CTCCAAG 2 -- us2k10--------
    rs1820652121,2
    --42008698(+) AGCTCC/GAAGAG 2 -- us2k10--------
    rs1112393491,2
    C,F--42008759(+) CCTGGC/TGCATG 2 -- us2k12Minor allele frequency- T:0.05CSA WA 120
    rs1379816081,2
    --42008761(+) TGGCGC/TATGGT 2 -- us2k10--------
    rs1864012191,2
    --42008992(+) ATCTAC/TCCCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for AP3M2 (42010464 - 42029191 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AP3M2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AP3M2
    DNA2.0 Custom Variant and Variant Library Synthesis for AP3M2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610469    OMIM disorders: --

    3 diseases for AP3M2:    About MalaCards
    hermansky-pudlak syndrome    endocarditis    schizophrenia


    AP3M2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): AP3M2
    Human Genome Epidemiology (HuGE) Navigator: AP3M2 (2 documents)

    Export disorders for AP3M2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AP3M2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with AP3M2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification. (PubMed id 7601449)1, 2, 3 Koyama K.... Nakamura Y. (1995)
    2. Association analysis between schizophrenia and the AP -3 complex genes. (PubMed id 19481122)1, 4 Hashimoto R....Kunugi H. (2009)
    3. Mutation screening of AP3M2 in Japanese epilepsy patients. (PubMed id 17293072)1, 4 Huang M.C....Kojima T. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Human immunodeficiency virus type-1 gag and host vesic ular trafficking pathways. (PubMed id 20012524)1 Chu H....Spearman P. (2009)
    9. HIV-1 Vpu inhibits accumulation of the envelope glycop rotein within clathrin-coated, Gag-containing endosomes. (PubMed id 18076669)1 Van Damme N. and Guatelli J. (2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10947 HGNC: 570 AceView: AP3M2 Ensembl:ENSG00000070718 euGenes: HUgn10947
    ECgene: AP3M2 Kegg: 10947 H-InvDB: AP3M2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AP3M2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AP3M2 gene:
    Search GeneIP for patents involving AP3M2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AP3M2  
     OriGene qPCR primer pairs and template standards for AP3M2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AP3M2  
     OriGene qSTAR qPCR primer pairs in human, mouse for AP3M2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AP3M2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AP3M2   OriGene Custom Protein Services for AP3M2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AP3M2
     QIAGEN SeqTarget long-range PCR primers for resequencing AP3M2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AP3M2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AP3M2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AP3M2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AP3M2
     GenScript Custom Purified and Recombinant Proteins Services for AP3M2 GenScript cDNA clones with any tag delivered in your preferred vector for AP3M2
     GenScript Custom Assay Services for AP3M2 GenScript Custom Superior Antibodies Services for AP3M2
     GenScript Custom overexpressing Cell Line Services for AP3M2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AP3M2 promoter
     Search Chromatin IP Primers for AP3M2
     RT2 qPCR Primer Assay in human, mouse, rat AP3M2
     Search GNC Networks for AP3M2
     SABiosciences Custom PCR Arrays for AP3M2
     Search Tocris compounds for AP3M2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AP3M2 antibodies
     AP3M2 proteins
     AP3M2 lysates
     Antibodies for AP3M2
     See all of Abcam's Antibodies, Kits and Proteins for AP3M2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for AP3M2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AP3M2
     SwitchGear 3'UTR luciferase reporter plasmids for AP3M2
     SwitchGear Promoter luciferase reporter plasmids for AP3M2
     ThermoFisher Antibodies for AP3M2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AP3M2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AP3M2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AP3M2
    Customized:
     lentivirus for stable overexpression of AP3M2
     lentivirus expression plasmids for stable overexpression of AP3M2
     adenovirus for overexpression of AP3M2
     LSBio Antibodies in human, mouse, rat for AP3M2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AP3M2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4