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Aliases for AP3M2 Gene

Aliases for AP3M2 Gene

  • Adaptor-Related Protein Complex 3, Mu 2 Subunit 2 3
  • Clathrin Assembly Protein Assembly Protein Complex 3 Mu-2 Medium Chain 3 4
  • Clathrin Coat-Associated Protein AP47 Homolog 2 3 4
  • Adaptor-Related Protein Complex 3 Subunit Mu-2 3 4
  • Clathrin Coat Assembly Protein AP47 Homolog 2 3 4
  • HA1 47 KDa Subunit Homolog 2 3 4
  • Mu3B-Adaptin 3 4
  • CLA20 3 6
  • P47B 3 4
  • Clathrin Assembly Protein Assembly Protein Complex 1 Medium Chain Homolog 2 3
  • Adapter-Related Protein Complex 3 Mu-2 Subunit 3
  • Adapter-Related Protein Complex 3 Subunit Mu-2 3
  • Golgi Adaptor AP-1 47 KDA Protein Homolog 2 3
  • Golgi Adaptor AP-1 47 KDa Protein Homolog 2 4
  • Clathrin-Associated Protein AP47 Homolog 2 3
  • HA1 47kDA Subunit Homolog 2 3
  • AP-3 Complex Subunit Mu-2 3
  • AP47B 3

External Ids for AP3M2 Gene

Previous GeneCards Identifiers for AP3M2 Gene

  • GC08P041394
  • GC08P042039
  • GC08P041751
  • GC08P042027
  • GC08P040537

Summaries for AP3M2 Gene

Entrez Gene Summary for AP3M2 Gene

  • This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]

GeneCards Summary for AP3M2 Gene

AP3M2 (Adaptor-Related Protein Complex 3, Mu 2 Subunit) is a Protein Coding gene. Among its related pathways are Lysosome. An important paralog of this gene is AP1M2.

UniProtKB/Swiss-Prot for AP3M2 Gene

  • Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP3M2 Gene

Genomics for AP3M2 Gene

Regulatory Elements for AP3M2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AP3M2 Gene

Start:
42,152,946 bp from pter
End:
42,171,673 bp from pter
Size:
18,728 bases
Orientation:
Plus strand

Genomic View for AP3M2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AP3M2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP3M2 Gene

Proteins for AP3M2 Gene

  • Protein details for AP3M2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53677-AP3M2_HUMAN
    Recommended name:
    AP-3 complex subunit mu-2
    Protein Accession:
    P53677
    Secondary Accessions:
    • B2RCR0
    • D3DSY2
    • Q7Z472

    Protein attributes for AP3M2 Gene

    Size:
    418 amino acids
    Molecular mass:
    46977 Da
    Quaternary structure:
    • AP-3 associates with the BLOC-1 complex (By similarity). Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).

    Alternative splice isoforms for AP3M2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP3M2 Gene

Proteomics data for AP3M2 Gene at MOPED

Post-translational modifications for AP3M2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for AP3M2 Gene

Domains for AP3M2 Gene

Suggested Antigen Peptide Sequences for AP3M2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53677

UniProtKB/Swiss-Prot:

AP3M2_HUMAN :
  • P53677
Domain:
  • Contains 1 MHD (mu homology) domain.
Family:
  • Belongs to the adaptor complexes medium subunit family.
genes like me logo Genes that share domains with AP3M2: view

No data available for Gene Families for AP3M2 Gene

Function for AP3M2 Gene

Molecular function for AP3M2 Gene

UniProtKB/Swiss-Prot Function:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Gene Ontology (GO) - Molecular Function for AP3M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with AP3M2: view

Phenotypes for AP3M2 Gene

genes like me logo Genes that share phenotypes with AP3M2: view

Animal Models for AP3M2 Gene

MGI Knock Outs for AP3M2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AP3M2 Gene

Localization for AP3M2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP3M2 Gene

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP3M2 Gene COMPARTMENTS Subcellular localization image for AP3M2 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for AP3M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0030119 AP-type membrane coat adaptor complex TAS 8076832
GO:0030131 clathrin adaptor complex IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with AP3M2: view

Pathways for AP3M2 Gene

SuperPathways for AP3M2 Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with AP3M2: view

Pathways by source for AP3M2 Gene

1 KEGG pathway for AP3M2 Gene

Interacting Proteins for AP3M2 Gene

Gene Ontology (GO) - Biological Process for AP3M2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006886 intracellular protein transport IEA --
GO:0008089 anterograde axon cargo transport ISS --
GO:0016192 vesicle-mediated transport --
GO:0048490 anterograde synaptic vesicle transport ISS --
genes like me logo Genes that share ontologies with AP3M2: view

Transcripts for AP3M2 Gene

Unigene Clusters for AP3M2 Gene

Adaptor-related protein complex 3, mu 2 subunit:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AP3M2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP3M2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - -
SP7:
SP8: - - -
SP9:
SP10:

Relevant External Links for AP3M2 Gene

GeneLoc Exon Structure for
AP3M2
ECgene alternative splicing isoforms for
AP3M2

Expression for AP3M2 Gene

mRNA expression in normal human tissues for AP3M2 Gene

Protein differential expression in normal tissues for AP3M2 Gene

This gene is overexpressed in Frontal cortex (18.4), Retina (11.9), Brain (10.1), and Fetal Brain (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AP3M2 Gene

SOURCE GeneReport for Unigene cluster for AP3M2 Gene Hs.654529

genes like me logo Genes that share expressions with AP3M2: view

Expression partners for AP3M2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AP3M2 Gene

Orthologs for AP3M2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP3M2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AP3M2 35
  • 89.71 (n)
  • 99.76 (a)
AP3M2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP3M2 35
  • 92.74 (n)
  • 99.52 (a)
AP3M2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap3m2 35
  • 88.6 (n)
  • 98.33 (a)
Ap3m2 16
Ap3m2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AP3M2 35
  • 99.76 (n)
  • 100 (a)
AP3M2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ap3m2 35
  • 88.36 (n)
  • 98.33 (a)
oppossum
(Monodelphis domestica)
Mammalia AP3M2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AP3M2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves AP3M2 35
  • 83.81 (n)
  • 96.65 (a)
AP3M2 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP3M2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ap3m2 35
  • 77.83 (n)
  • 92.34 (a)
Str.6024 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32423 35
zebrafish
(Danio rerio)
Actinopterygii ap3m2 35
  • 77.11 (n)
  • 91.15 (a)
ap3m2 36
  • 91 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7655 35
fruit fly
(Drosophila melanogaster)
Insecta cm 37
  • 69 (a)
cm 35
  • 65.3 (n)
  • 70.29 (a)
cm 36
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001484 35
  • 62.39 (n)
  • 67.8 (a)
worm
(Caenorhabditis elegans)
Secernentea apm-3 36
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APM1 36
  • 23 (a)
OneToMany
APM3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ZIP4 35
  • 50.16 (n)
  • 44.66 (a)
rice
(Oryza sativa)
Liliopsida Os05g0383100 35
  • 50.28 (n)
  • 43.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3115 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
Species with no ortholog for AP3M2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AP3M2 Gene

ENSEMBL:
Gene Tree for AP3M2 (if available)
TreeFam:
Gene Tree for AP3M2 (if available)

Paralogs for AP3M2 Gene

Paralogs for AP3M2 Gene

Pseudogenes.org Pseudogenes for AP3M2 Gene

genes like me logo Genes that share paralogs with AP3M2: view

Variants for AP3M2 Gene

Sequence variations from dbSNP and Humsavar for AP3M2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10994 -- 42,171,012(+) TGTCC(A/C/T)GTCAC utr-variant-3-prime
rs1050262 -- 42,169,469(+) AATGT(C/T)AGTCA utr-variant-3-prime
rs1050263 -- 42,169,620(+) AGTTG(A/T)GTTGG utr-variant-3-prime
rs1050264 -- 42,170,014(+) AGGGT(C/T)TGTGT utr-variant-3-prime
rs1050265 -- 42,170,162(+) CTGTC(A/G)CCCTA utr-variant-3-prime

Relevant External Links for AP3M2 Gene

HapMap Linkage Disequilibrium report
AP3M2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AP3M2 Gene

Disorders for AP3M2 Gene

Relevant External Links for AP3M2

Genetic Association Database (GAD)
AP3M2
Human Genome Epidemiology (HuGE) Navigator
AP3M2

No disorders were found for AP3M2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AP3M2 Gene

Publications for AP3M2 Gene

  1. Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification. (PMID: 7601449) Koyama K. … Nakamura Y. (Genomics 1995) 2 3 4
  2. Association analysis between schizophrenia and the AP-3 complex genes. (PMID: 19481122) Hashimoto R. … Kunugi H. (Neurosci. Res. 2009) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Mutation screening of AP3M2 in Japanese epilepsy patients. (PMID: 17293072) Huang M.C. … Kojima T. (Brain Dev. 2007) 3 48
  5. HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes. (PMID: 18076669) Van Damme N. … Guatelli J. (Cell. Microbiol. 2008) 3

Products for AP3M2 Gene

Sources for AP3M2 Gene

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